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Patent code US9802904

Compile Data Set for Download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
USP1/UAF1


(Homo sapiens (Human))
BDBM50069762
PNG
(CHEMBL3182437 | ML323 | US9802904, 87)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1
Show InChI InChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
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US Patent
n/an/a 17n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352028
PNG
(US9802904, 89)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NC2(CC2)c2ccc(cc2)-c2cccnc2)n1
Show InChI InChI=1S/C28H28N4/c1-19(2)24-8-4-5-9-25(24)27-30-17-20(3)26(31-27)32-28(14-15-28)23-12-10-21(11-13-23)22-7-6-16-29-18-22/h4-13,16-19H,14-15H2,1-3H3,(H,30,31,32)
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n/an/a 34n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352011
PNG
(US9802904, 72)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccc(C)nc2)n1
Show InChI InChI=1S/C27H28N4/c1-18(2)24-7-5-6-8-25(24)27-29-15-19(3)26(31-27)30-16-21-10-13-22(14-11-21)23-12-9-20(4)28-17-23/h5-15,17-18H,16H2,1-4H3,(H,29,30,31)
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n/an/a 43n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350387
PNG
(US9802904, 60)
Show SMILES CCc1cnc(nc1NCc1ccc(cc1)-c1ccccc1)-c1ccccc1C(C)C
Show InChI InChI=1S/C28H29N3/c1-4-22-19-30-28(26-13-9-8-12-25(26)20(2)3)31-27(22)29-18-21-14-16-24(17-15-21)23-10-6-5-7-11-23/h5-17,19-20H,4,18H2,1-3H3,(H,29,30,31)
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n/an/a 43n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352013
PNG
(US9802904, 74)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCC2CCN(CC2)c2cccnc2)n1
Show InChI InChI=1S/C25H31N5/c1-18(2)22-8-4-5-9-23(22)25-27-15-19(3)24(29-25)28-16-20-10-13-30(14-11-20)21-7-6-12-26-17-21/h4-9,12,15,17-18,20H,10-11,13-14,16H2,1-3H3,(H,27,28,29)
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US Patent
n/an/a 48n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352018
PNG
(US9802904, 79)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccc(F)nc2)n1
Show InChI InChI=1S/C26H25FN4/c1-17(2)22-6-4-5-7-23(22)26-29-14-18(3)25(31-26)30-15-19-8-10-20(11-9-19)21-12-13-24(27)28-16-21/h4-14,16-17H,15H2,1-3H3,(H,29,30,31)
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n/an/a 61n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351737
PNG
(US9802904, 61)
Show SMILES CC(C)c1ccccc1-c1ncc(F)c(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C26H24FN3/c1-18(2)22-10-6-7-11-23(22)25-29-17-24(27)26(30-25)28-16-19-12-14-21(15-13-19)20-8-4-3-5-9-20/h3-15,17-18H,16H2,1-2H3,(H,28,29,30)
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n/an/a 61n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352025
PNG
(US9802904, 86)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2cccnc2)n1
Show InChI InChI=1S/C26H26N4/c1-18(2)23-8-4-5-9-24(23)26-28-15-19(3)25(30-26)29-16-20-10-12-21(13-11-20)22-7-6-14-27-17-22/h4-15,17-18H,16H2,1-3H3,(H,28,29,30)
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n/an/a 61n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350386
PNG
(US9802904, 59)
Show SMILES CC(C)c1ccccc1-c1ncc(O)c(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C26H25N3O/c1-18(2)22-10-6-7-11-23(22)25-28-17-24(30)26(29-25)27-16-19-12-14-21(15-13-19)20-8-4-3-5-9-20/h3-15,17-18,30H,16H2,1-2H3,(H,27,28,29)
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n/an/a 68n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM50069762
PNG
(CHEMBL3182437 | ML323 | US9802904, 87)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1
Show InChI InChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
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n/an/a 76n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351922
PNG
(US9802904, 64)
Show SMILES CSc1cnc(nc1NCc1ccc(cc1)-c1ccccc1)-c1ccccc1C(C)C
Show InChI InChI=1S/C27H27N3S/c1-19(2)23-11-7-8-12-24(23)26-29-18-25(31-3)27(30-26)28-17-20-13-15-22(16-14-20)21-9-5-4-6-10-21/h4-16,18-19H,17H2,1-3H3,(H,28,29,30)
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n/an/a 86n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352015
PNG
(US9802904, 76)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCC2CCN(CC2)c2cnccn2)n1
Show InChI InChI=1S/C24H30N6/c1-17(2)20-6-4-5-7-21(20)24-27-14-18(3)23(29-24)28-15-19-8-12-30(13-9-19)22-16-25-10-11-26-22/h4-7,10-11,14,16-17,19H,8-9,12-13,15H2,1-3H3,(H,27,28,29)
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n/an/a 120n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350377
PNG
(US9802904, 51)
Show SMILES CC(C)c1ccccc1-c1nc(NCc2ccc(cc2)-c2ccccc2)c2ccsc2n1
Show InChI InChI=1S/C28H25N3S/c1-19(2)23-10-6-7-11-24(23)27-30-26(25-16-17-32-28(25)31-27)29-18-20-12-14-22(15-13-20)21-8-4-3-5-9-21/h3-17,19H,18H2,1-2H3,(H,29,30,31)
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n/an/a 120n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350385
PNG
(US9802904, 59)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C27H27N3/c1-19(2)24-11-7-8-12-25(24)27-28-17-20(3)26(30-27)29-18-21-13-15-23(16-14-21)22-9-5-4-6-10-22/h4-17,19H,18H2,1-3H3,(H,28,29,30)
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n/an/a 120n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350383
PNG
(US9802904, 57)
Show SMILES CC(C)c1ccccc1C1=NC2C=COC2C(NCc2ccc(cc2)-c2ccccc2)=N1
Show InChI InChI=1S/C28H27N3O/c1-19(2)23-10-6-7-11-24(23)27-30-25-16-17-32-26(25)28(31-27)29-18-20-12-14-22(15-13-20)21-8-4-3-5-9-21/h3-17,19,25-26H,18H2,1-2H3,(H,29,30,31)
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n/an/a 140n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351934
PNG
(US9802904, 66)
Show SMILES CC(C)c1ccccc1-c1nc(C)c(C)c(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C28H29N3/c1-19(2)25-12-8-9-13-26(25)28-30-21(4)20(3)27(31-28)29-18-22-14-16-24(17-15-22)23-10-6-5-7-11-23/h5-17,19H,18H2,1-4H3,(H,29,30,31)
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n/an/a 140n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351941
PNG
(US9802904, 67)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2cccc(C)c2)n1
Show InChI InChI=1S/C22H25N3/c1-15(2)19-10-5-6-11-20(19)22-23-13-17(4)21(25-22)24-14-18-9-7-8-16(3)12-18/h5-13,15H,14H2,1-4H3,(H,23,24,25)
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n/an/a 140n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350384
PNG
(US9802904, 58)
Show SMILES CC(C)c1ccccc1C1=NCCC(NCc2ccc(cc2)-c2ccccc2)=N1
Show InChI InChI=1S/C26H27N3/c1-19(2)23-10-6-7-11-24(23)26-27-17-16-25(29-26)28-18-20-12-14-22(15-13-20)21-8-4-3-5-9-21/h3-15,19H,16-18H2,1-2H3,(H,27,28,29)
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n/an/a 150n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352027
PNG
(US9802904, 88)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2cc[nH]n2)n1
Show InChI InChI=1S/C24H25N5/c1-16(2)20-6-4-5-7-21(20)24-25-14-17(3)23(28-24)26-15-18-8-10-19(11-9-18)22-12-13-27-29-22/h4-14,16H,15H2,1-3H3,(H,27,29)(H,25,26,28)
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n/an/a 150n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351827
PNG
(US9802904, 63)
Show SMILES CC(C)c1ccccc1-c1ncc(N(C)C)c(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C28H30N4/c1-20(2)24-12-8-9-13-25(24)27-30-19-26(32(3)4)28(31-27)29-18-21-14-16-23(17-15-21)22-10-6-5-7-11-22/h5-17,19-20H,18H2,1-4H3,(H,29,30,31)
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n/an/a 150n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352029
PNG
(US9802904, 90)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NC(C)(C)c2ccc(cc2)-c2cccnc2)n1
Show InChI InChI=1S/C28H30N4/c1-19(2)24-10-6-7-11-25(24)27-30-17-20(3)26(31-27)32-28(4,5)23-14-12-21(13-15-23)22-9-8-16-29-18-22/h6-19H,1-5H3,(H,30,31,32)
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n/an/a 190n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351968
PNG
(US9802904, 69)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2cccs2)n1
Show InChI InChI=1S/C19H21N3S/c1-13(2)16-8-4-5-9-17(16)19-20-11-14(3)18(22-19)21-12-15-7-6-10-23-15/h4-11,13H,12H2,1-3H3,(H,20,21,22)
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n/an/a 220n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350381
PNG
(US9802904, 55)
Show SMILES CC(C)c1ccccc1C1=NC2CNCCC2C(NCc2ccc(cc2)-c2ccccc2)=N1
Show InChI InChI=1S/C29H32N4/c1-20(2)24-10-6-7-11-25(24)29-32-27-19-30-17-16-26(27)28(33-29)31-18-21-12-14-23(15-13-21)22-8-4-3-5-9-22/h3-15,20,26-27,30H,16-19H2,1-2H3,(H,31,32,33)
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n/an/a 220n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352021
PNG
(US9802904, 82)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2cnn[nH]2)n1
Show InChI InChI=1S/C23H24N6/c1-15(2)19-6-4-5-7-20(19)23-24-12-16(3)22(27-23)25-13-17-8-10-18(11-9-17)21-14-26-29-28-21/h4-12,14-15H,13H2,1-3H3,(H,24,25,27)(H,26,28,29)
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n/an/a 240n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350378
PNG
(US9802904, 52)
Show SMILES CC(C)c1ccccc1-c1nc(NCc2ccc(cc2)-c2ccccc2)c2nc[nH]c2n1
Show InChI InChI=1S/C27H25N5/c1-18(2)22-10-6-7-11-23(22)25-31-26(24-27(32-25)30-17-29-24)28-16-19-12-14-21(15-13-19)20-8-4-3-5-9-20/h3-15,17-18H,16H2,1-2H3,(H2,28,29,30,31,32)
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n/an/a 240n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351779
PNG
(US9802904, 62)
Show SMILES CC(C)c1ccccc1-c1ncc(N)c(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C26H26N4/c1-18(2)22-10-6-7-11-23(22)25-29-17-24(27)26(30-25)28-16-19-12-14-21(15-13-19)20-8-4-3-5-9-20/h3-15,17-18H,16,27H2,1-2H3,(H,28,29,30)
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n/an/a 270n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350376
PNG
(US9802904, 50)
Show SMILES CC(C)c1ccccc1-c1nc(NCc2ccc(cc2)-c2ccccc2)c2sccc2n1
Show InChI InChI=1S/C28H25N3S/c1-19(2)23-10-6-7-11-24(23)27-30-25-16-17-32-26(25)28(31-27)29-18-20-12-14-22(15-13-20)21-8-4-3-5-9-21/h3-17,19H,18H2,1-2H3,(H,29,30,31)
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n/an/a 340n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352012
PNG
(US9802904, 73)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C27H25F3N4/c1-17(2)22-6-4-5-7-23(22)26-32-15-18(3)25(34-26)33-16-19-8-10-20(11-9-19)21-12-13-31-24(14-21)27(28,29)30/h4-15,17H,16H2,1-3H3,(H,32,33,34)
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n/an/a 380n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351932
PNG
(US9802904, 65)
Show SMILES CC(C)c1ccccc1-c1nc(C)cc(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C27H27N3/c1-19(2)24-11-7-8-12-25(24)27-29-20(3)17-26(30-27)28-18-21-13-15-23(16-14-21)22-9-5-4-6-10-22/h4-17,19H,18H2,1-3H3,(H,28,29,30)
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n/an/a 480n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352017
PNG
(US9802904, 78)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCC2CCN(C2)c2cccnc2)n1
Show InChI InChI=1S/C24H29N5/c1-17(2)21-8-4-5-9-22(21)24-26-13-18(3)23(28-24)27-14-19-10-12-29(16-19)20-7-6-11-25-15-20/h4-9,11,13,15,17,19H,10,12,14,16H2,1-3H3,(H,26,27,28)
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n/an/a 480n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350368
PNG
(US9802904, 19)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)-c3ccncc3)cccc2n1
Show InChI InChI=1S/C27H19F3N4/c28-27(29,30)23-5-2-1-4-21(23)26-33-17-22-24(6-3-7-25(22)34-26)32-16-18-8-10-19(11-9-18)20-12-14-31-15-13-20/h1-15,17,32H,16H2
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n/an/a 480n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350382
PNG
(US9802904, 56)
Show SMILES CC(C)c1ccccc1C1=NC2CCCC2C(NCc2ccc(cc2)-c2ccccc2)=N1
Show InChI InChI=1S/C29H31N3/c1-20(2)24-11-6-7-12-25(24)29-31-27-14-8-13-26(27)28(32-29)30-19-21-15-17-23(18-16-21)22-9-4-3-5-10-22/h3-7,9-12,15-18,20,26-27H,8,13-14,19H2,1-2H3,(H,30,31,32)
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n/an/a 480n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350369
PNG
(US9802904, 20 | US9802904, 21)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)-c3cccnc3)cccc2n1
Show InChI InChI=1S/C27H19F3N4/c28-27(29,30)23-7-2-1-6-21(23)26-33-17-22-24(8-3-9-25(22)34-26)32-15-18-10-12-19(13-11-18)20-5-4-14-31-16-20/h1-14,16-17,32H,15H2
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n/an/a 610n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352008
PNG
(US9802904, 70)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NC(CO)c2cccc(C)c2)n1
Show InChI InChI=1S/C23H27N3O/c1-15(2)19-10-5-6-11-20(19)23-24-13-17(4)22(26-23)25-21(14-27)18-9-7-8-16(3)12-18/h5-13,15,21,27H,14H2,1-4H3,(H,24,25,26)
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n/an/a 1.10E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350365
PNG
(US9802904, 16)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)-c3ccc(Cl)c(Cl)c3)cccc2n1
Show InChI InChI=1S/C28H18Cl2F3N3/c29-23-13-12-19(14-24(23)30)18-10-8-17(9-11-18)15-34-25-6-3-7-26-21(25)16-35-27(36-26)20-4-1-2-5-22(20)28(31,32)33/h1-14,16,34H,15H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350380
PNG
(US9802904, 54)
Show SMILES CC(C)c1ccccc1-c1nc(NCc2ccc(cc2)-c2ccccc2)c2cccn2n1
Show InChI InChI=1S/C28H26N4/c1-20(2)24-11-6-7-12-25(24)27-30-28(26-13-8-18-32(26)31-27)29-19-21-14-16-23(17-15-21)22-9-4-3-5-10-22/h3-18,20H,19H2,1-2H3,(H,29,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350367
PNG
(US9802904, 18)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)-c3cccc(Cl)c3)cccc2n1
Show InChI InChI=1S/C28H19ClF3N3/c29-21-6-3-5-20(15-21)19-13-11-18(12-14-19)16-33-25-9-4-10-26-23(25)17-34-27(35-26)22-7-1-2-8-24(22)28(30,31)32/h1-15,17,33H,16H2
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n/an/a 1.70E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350369
PNG
(US9802904, 20 | US9802904, 21)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)-c3cccnc3)cccc2n1
Show InChI InChI=1S/C27H19F3N4/c28-27(29,30)23-7-2-1-6-21(23)26-33-17-22-24(8-3-9-25(22)34-26)32-15-18-10-12-19(13-11-18)20-5-4-14-31-16-20/h1-14,16-17,32H,15H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350379
PNG
(US9802904, 53)
Show SMILES CC(C)c1ccccc1-c1nc2CCCc2c(NCc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C29H29N3/c1-20(2)24-11-6-7-12-25(24)29-31-27-14-8-13-26(27)28(32-29)30-19-21-15-17-23(18-16-21)22-9-4-3-5-10-22/h3-7,9-12,15-18,20H,8,13-14,19H2,1-2H3,(H,30,31,32)
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n/an/a 2.12E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM351954
PNG
(US9802904, 68)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2cccnc2)n1
Show InChI InChI=1S/C20H22N4/c1-14(2)17-8-4-5-9-18(17)20-22-11-15(3)19(24-20)23-13-16-7-6-10-21-12-16/h4-12,14H,13H2,1-3H3,(H,22,23,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350371
PNG
(US9802904, 22)
Show SMILES FC(F)(F)c1cc(ccc1Cl)-c1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C29H18ClF6N3/c30-24-13-12-19(14-23(24)29(34,35)36)18-10-8-17(9-11-18)15-37-25-6-3-7-26-21(25)16-38-27(39-26)20-4-1-2-5-22(20)28(31,32)33/h1-14,16,37H,15H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350366
PNG
(US9802904, 17)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)-c3ccc(Cl)cc3)cccc2n1
Show InChI InChI=1S/C28H19ClF3N3/c29-21-14-12-20(13-15-21)19-10-8-18(9-11-19)16-33-25-6-3-7-26-23(25)17-34-27(35-26)22-4-1-2-5-24(22)28(30,31)32/h1-15,17,33H,16H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352014
PNG
(US9802904, 75)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCC2CCN(CC2)c2ccc(C)nc2)n1
Show InChI InChI=1S/C26H33N5/c1-18(2)23-7-5-6-8-24(23)26-28-15-19(3)25(30-26)29-16-21-11-13-31(14-12-21)22-10-9-20(4)27-17-22/h5-10,15,17-18,21H,11-14,16H2,1-4H3,(H,28,29,30)
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US Patent
n/an/a 2.20E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350353
PNG
(US9802904, 5)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccccc3)cccc2n1
Show InChI InChI=1S/C22H16F3N3/c23-22(24,25)18-10-5-4-9-16(18)21-27-14-17-19(11-6-12-20(17)28-21)26-13-15-7-2-1-3-8-15/h1-12,14,26H,13H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350357
PNG
(US9802904, 9)
Show SMILES Fc1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C22H15F4N3/c23-15-10-8-14(9-11-15)12-27-19-6-3-7-20-17(19)13-28-21(29-20)16-4-1-2-5-18(16)22(24,25)26/h1-11,13,27H,12H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350354
PNG
(US9802904, 6)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)-c3ccccc3)cccc2n1
Show InChI InChI=1S/C28H20F3N3/c29-28(30,31)24-10-5-4-9-22(24)27-33-18-23-25(11-6-12-26(23)34-27)32-17-19-13-15-21(16-14-19)20-7-2-1-3-8-20/h1-16,18,32H,17H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350356
PNG
(US9802904, 8)
Show SMILES COc1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C23H18F3N3O/c1-30-16-11-9-15(10-12-16)13-27-20-7-4-8-21-18(20)14-28-22(29-21)17-5-2-3-6-19(17)23(24,25)26/h2-12,14,27H,13H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350359
PNG
(US9802904, 10)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(Cl)cc3)cccc2n1
Show InChI InChI=1S/C22H15ClF3N3/c23-15-10-8-14(9-11-15)12-27-19-6-3-7-20-17(19)13-28-21(29-20)16-4-1-2-5-18(16)22(24,25)26/h1-11,13,27H,12H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350363
PNG
(US9802904, 14)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)C#N)cccc2n1
Show InChI InChI=1S/C23H15F3N4/c24-23(25,26)19-5-2-1-4-17(19)22-29-14-18-20(6-3-7-21(18)30-22)28-13-16-10-8-15(12-27)9-11-16/h1-11,14,28H,13H2
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n/an/a 3.40E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350374
PNG
(US9802904, 24)
Show SMILES FC(F)(F)c1cc(ccn1)-c1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C28H18F6N4/c29-27(30,31)22-5-2-1-4-20(22)26-37-16-21-23(6-3-7-24(21)38-26)36-15-17-8-10-18(11-9-17)19-12-13-35-25(14-19)28(32,33)34/h1-14,16,36H,15H2
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n/an/a 4.30E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350362
PNG
(US9802904, 13)
Show SMILES Cc1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)s1
Show InChI InChI=1S/C21H16F3N3S/c1-13-9-10-14(28-13)11-25-18-7-4-8-19-16(18)12-26-20(27-19)15-5-2-3-6-17(15)21(22,23)24/h2-10,12,25H,11H2,1H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350360
PNG
(US9802904, 11)
Show SMILES FC(F)(F)c1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C23H15F6N3/c24-22(25,26)15-10-8-14(9-11-15)12-30-19-6-3-7-20-17(19)13-31-21(32-20)16-4-1-2-5-18(16)23(27,28)29/h1-11,13,30H,12H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350355
PNG
(US9802904, 7)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc4OCOc4c3)cccc2n1
Show InChI InChI=1S/C23H16F3N3O2/c24-23(25,26)17-5-2-1-4-15(17)22-28-12-16-18(6-3-7-19(16)29-22)27-11-14-8-9-20-21(10-14)31-13-30-20/h1-10,12,27H,11,13H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350375
PNG
(US9802904, 25)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)C3CCCCC3)cccc2n1
Show InChI InChI=1S/C28H26F3N3/c29-28(30,31)24-10-5-4-9-22(24)27-33-18-23-25(11-6-12-26(23)34-27)32-17-19-13-15-21(16-14-19)20-7-2-1-3-8-20/h4-6,9-16,18,20,32H,1-3,7-8,17H2
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n/an/a 5.80E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352023
PNG
(US9802904, 84)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)C(N)=O)n1
Show InChI InChI=1S/C22H24N4O/c1-14(2)18-6-4-5-7-19(18)22-24-12-15(3)21(26-22)25-13-16-8-10-17(11-9-16)20(23)27/h4-12,14H,13H2,1-3H3,(H2,23,27)(H,24,25,26)
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n/an/a 6.80E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352016
PNG
(US9802904, 77)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCC2CC(C2)c2cccnc2)n1
Show InChI InChI=1S/C24H28N4/c1-16(2)21-8-4-5-9-22(21)24-26-13-17(3)23(28-24)27-14-18-11-20(12-18)19-7-6-10-25-15-19/h4-10,13,15-16,18,20H,11-12,14H2,1-3H3,(H,26,27,28)
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n/an/a 6.80E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352019
PNG
(US9802904, 80)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)C2CCCNC2)n1
Show InChI InChI=1S/C26H32N4/c1-18(2)23-8-4-5-9-24(23)26-28-15-19(3)25(30-26)29-16-20-10-12-21(13-11-20)22-7-6-14-27-17-22/h4-5,8-13,15,18,22,27H,6-7,14,16-17H2,1-3H3,(H,28,29,30)
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n/an/a 7.60E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350364
PNG
(US9802904, 15)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCC#Cc3cccnc3)cccc2n1
Show InChI InChI=1S/C23H15F3N4/c24-23(25,26)19-9-2-1-8-17(19)22-29-15-18-20(10-3-11-21(18)30-22)28-13-5-7-16-6-4-12-27-14-16/h1-4,6,8-12,14-15,28H,13H2
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n/an/a 7.60E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350373
PNG
(US9802904, 23)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(cc3)N3CCOCC3)cccc2n1
Show InChI InChI=1S/C26H23F3N4O/c27-26(28,29)22-5-2-1-4-20(22)25-31-17-21-23(6-3-7-24(21)32-25)30-16-18-8-10-19(11-9-18)33-12-14-34-15-13-33/h1-11,17,30H,12-16H2
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n/an/a 7.60E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352022
PNG
(US9802904, 83)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2nnn[nH]2)n1
Show InChI InChI=1S/C22H23N7/c1-14(2)18-6-4-5-7-19(18)22-23-12-15(3)20(25-22)24-13-16-8-10-17(11-9-16)21-26-28-29-27-21/h4-12,14H,13H2,1-3H3,(H,23,24,25)(H,26,27,28,29)
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n/an/a 7.60E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350352
PNG
(US9802904, 1)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3cccs3)cccc2n1
Show InChI InChI=1S/C20H14F3N3S/c21-20(22,23)16-7-2-1-6-14(16)19-25-12-15-17(8-3-9-18(15)26-19)24-11-13-5-4-10-27-13/h1-10,12,24H,11H2
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n/an/a 7.90E+3n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM350361
PNG
(US9802904, 12)
Show SMILES FC(F)(F)c1ccccc1-c1ncc2c(NCc3ccc(Cl)c(Cl)c3)cccc2n1
Show InChI InChI=1S/C22H14Cl2F3N3/c23-17-9-8-13(10-18(17)24)11-28-19-6-3-7-20-15(19)12-29-21(30-20)14-4-1-2-5-16(14)22(25,26)27/h1-10,12,28H,11H2
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n/an/a 1.10E+4n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352024
PNG
(US9802904, 85)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCC2CCN(CC2)C2COC2)n1
Show InChI InChI=1S/C23H32N4O/c1-16(2)20-6-4-5-7-21(20)23-24-12-17(3)22(26-23)25-13-18-8-10-27(11-9-18)19-14-28-15-19/h4-7,12,16,18-19H,8-11,13-15H2,1-3H3,(H,24,25,26)
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n/an/a 1.50E+4n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
USP1/UAF1


(Homo sapiens (Human))
BDBM352009
PNG
(US9802904, 71)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCC2CCN(C)CC2)n1
Show InChI InChI=1S/C21H30N4/c1-15(2)18-7-5-6-8-19(18)21-22-13-16(3)20(24-21)23-14-17-9-11-25(4)12-10-17/h5-8,13,15,17H,9-12,14H2,1-4H3,(H,22,23,24)
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UniChem
US Patent
n/an/a 3.00E+4n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...


US Patent US9802904 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%