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Patent code US9802915

Compile Data Set for Download or QSAR

Found 262 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165960
PNG
(US10604504, Example 206 | US9688629, 204 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CCN(Cc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22FN3O2/c1-4-19(28)27-9-8-14-6-5-7-15(17(14)11-27)21-18(24)10-16(23(25)29)22-20(21)12(2)13(3)26-22/h4-7,10,26H,1,8-9,11H2,2-3H3,(H2,25,29)
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n/an/a 0.0400n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165511
PNG
(US10604504, Example 168 | US9688629, 167 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CC4CCN(C4C3)C(=O)C=C)c2c1C)C(N)=O
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n/an/a 0.0400n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165458
PNG
(US10604504, Example 136 | US9688629, 136 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CCC[C@@H](C3)NC(=O)C#CC3CC3)c2c1C)C(N)=O
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n/an/a 0.0500n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166569
PNG
(US10604504, Example 219 | US9688629, 217 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(C3CCCN(C3)C(=O)C=C)c2c1C)C(N)=O
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n/an/a 0.0520n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165330
PNG
(US10604504, Example 126 | US9688629, 126 | US98029...)
Show SMILES CCC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
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n/an/a 0.0600n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165334
PNG
(US10604504, Example 128 | US9688629, 128 | US98029...)
Show SMILES CCCC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164875
PNG
(US10604504, Example 23 | US9688629, 23 | US9802915...)
Show SMILES CN(c1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12)S(=O)(=O)C=C
Show InChI InChI=1S/C21H23N3O3S/c1-6-28(26,27)24(5)18-9-7-8-15(13(18)3)16-10-11-17(21(22)25)20-19(16)12(2)14(4)23-20/h6-11,23H,1H2,2-5H3,(H2,22,25)
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n/an/a 0.0700n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164805
PNG
(US10604504, Example 4 | US9688629, 4 | US9802915, ...)
Show SMILES Cc1[nH]c2c(ccc(-c3cccc(NS(=O)(=O)C=C)c3)c2c1C)C(N)=O
Show InChI InChI=1S/C19H19N3O3S/c1-4-26(24,25)22-14-7-5-6-13(10-14)15-8-9-16(19(20)23)18-17(15)11(2)12(3)21-18/h4-10,21-22H,1H2,2-3H3,(H2,20,23)
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n/an/a 0.0800n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165523
PNG
(US10604504, Example 172 | US9688629, 169 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CN(CC(F)c34)C(=O)C=C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164773
PNG
(US10604504, Example 174 | US9688629, 173 | US96886...)
Show SMILES CC#CC(=O)N1CCCC2CN(CC12)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164717
PNG
(US10604504, Example 160 | US9688629, 159 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CC4CCCN(C4C3)C(=O)C=C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164638
PNG
(BDBM166759 | US10604504, Example 223 | US9688629, ...)
Show SMILES CC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165995
PNG
(US10604504, Example 207 | US9688629, 207 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3ccc4CCN(C(=O)C=C)c4c3)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O2/c1-4-18(27)26-8-7-13-5-6-14(9-17(13)26)20-16(23)10-15(22(24)28)21-19(20)11(2)12(3)25-21/h4-6,9-10,25H,1,7-8H2,2-3H3,(H2,24,28)
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n/an/a 0.0940n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166785
PNG
(US10604504, Example 233 | US9688629, 233 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(C3=CN(CCC3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C19H20FN3O2/c1-4-15(24)23-7-5-6-12(9-23)17-14(20)8-13(19(21)25)18-16(17)10(2)11(3)22-18/h4,8-9,22H,1,5-7H2,2-3H3,(H2,21,25)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164717
PNG
(US10604504, Example 160 | US9688629, 159 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CC4CCCN(C4C3)C(=O)C=C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164793
PNG
(US10604504, Example 232 | US9688629, 231 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CN(CC(F)(F)c34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H20F3N3O2/c1-4-17(30)29-9-13-6-5-7-14(20(13)23(25,26)10-29)19-16(24)8-15(22(27)31)21-18(19)11(2)12(3)28-21/h4-8,28H,1,9-10H2,2-3H3,(H2,27,31)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164713
PNG
(US10604504, Example 95 | US9688629, 153 | US968862...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CN(CCc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22FN3O2/c1-4-19(28)27-9-8-15-14(11-27)6-5-7-16(15)21-18(24)10-17(23(25)29)22-20(21)12(2)13(3)26-22/h4-7,10,26H,1,8-9,11H2,2-3H3,(H2,25,29)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166831
PNG
(US10604504, Example 242 | US9688629, 242 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CCC[C@@H](C3)NC(=O)C#C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164875
PNG
(US10604504, Example 23 | US9688629, 23 | US9802915...)
Show SMILES CN(c1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12)S(=O)(=O)C=C
Show InChI InChI=1S/C21H23N3O3S/c1-6-28(26,27)24(5)18-9-7-8-15(13(18)3)16-10-11-17(21(22)25)20-19(16)12(2)14(4)23-20/h6-11,23H,1H2,2-5H3,(H2,22,25)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164638
PNG
(BDBM166759 | US10604504, Example 223 | US9688629, ...)
Show SMILES CC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165583
PNG
(US10604504, Example 196 | US9688629, 194 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4N(CCSc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O2S/c1-4-17(27)26-8-9-29-21-13(6-5-7-16(21)26)19-15(23)10-14(22(24)28)20-18(19)11(2)12(3)25-20/h4-7,10,25H,1,8-9H2,2-3H3,(H2,24,28)
PDB
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n/an/a 0.120n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165208
PNG
(US10604504, Example 33 | US9688629, 33 | US9802915...)
Show SMILES Cc1c[nH]c2c(ccc(-c3cccc(NS(=O)(=O)C=C)c3)c12)C(N)=O
Show InChI InChI=1S/C18H17N3O3S/c1-3-25(23,24)21-13-6-4-5-12(9-13)14-7-8-15(18(19)22)17-16(14)11(2)10-20-17/h3-10,20-21H,1H2,2H3,(H2,19,22)
PDB
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165301
PNG
(US10604504, Example 97 | US9688629, 97 | US9802915...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3ccc4N(CCCc4c3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22FN3O2/c1-4-19(28)27-9-5-6-14-10-15(7-8-18(14)27)21-17(24)11-16(23(25)29)22-20(21)12(2)13(3)26-22/h4,7-8,10-11,26H,1,5-6,9H2,2-3H3,(H2,25,29)
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n/an/a 0.120n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164713
PNG
(US10604504, Example 95 | US9688629, 153 | US968862...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CN(CCc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22FN3O2/c1-4-19(28)27-9-8-15-14(11-27)6-5-7-16(15)21-18(24)10-17(23(25)29)22-20(21)12(2)13(3)26-22/h4-7,10,26H,1,8-9,11H2,2-3H3,(H2,25,29)
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n/an/a 0.130n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165563
PNG
(US10604504, Example 185 | US9688629, 185 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(Cc3ccnc(C=C)c3)c2c1C)C(N)=O
Show InChI InChI=1S/C19H18FN3O/c1-4-13-7-12(5-6-22-13)8-14-16(20)9-15(19(21)24)18-17(14)10(2)11(3)23-18/h4-7,9,23H,1,8H2,2-3H3,(H2,21,24)
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n/an/a 0.130n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165577
PNG
(US10604504, Example 191 | US9688629, 189 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cc(F)cc4CN(CCc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H21F2N3O2/c1-4-19(29)28-6-5-15-13(10-28)7-14(24)8-16(15)21-18(25)9-17(23(26)30)22-20(21)11(2)12(3)27-22/h4,7-9,27H,1,5-6,10H2,2-3H3,(H2,26,30)
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n/an/a 0.130n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164876
PNG
(US10604504, Example 24 | US9688629, 24 | US9802915...)
Show SMILES CN(c1cccc(c1C)-c1ccc(C(N)=O)c2[nH]cc(C)c12)S(=O)(=O)C=C
Show InChI InChI=1S/C20H21N3O3S/c1-5-27(25,26)23(4)17-8-6-7-14(13(17)3)15-9-10-16(20(21)24)19-18(15)12(2)11-22-19/h5-11,22H,1H2,2-4H3,(H2,21,24)
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n/an/a 0.140n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165209
PNG
(US10604504, Example 34 | US9688629, 34 | US9802915...)
Show SMILES Cc1[nH]c2c(ccc(-c3cccc(NS(=O)(=O)C=C)c3C)c2c1C)C(N)=O
Show InChI InChI=1S/C20H21N3O3S/c1-5-27(25,26)23-17-8-6-7-14(12(17)3)15-9-10-16(20(21)24)19-18(15)11(2)13(4)22-19/h5-10,22-23H,1H2,2-4H3,(H2,21,24)
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n/an/a 0.140n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165319
PNG
(US10604504, Example 115 | US9688629, 115 | US98029...)
Show SMILES Cc1[nH]c2c(ccc(N3CCC[C@@H](C3)NC(=O)C#C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165328
PNG
(US10604504, Example 125 | US9688629, 125 | US98029...)
Show SMILES CC#CC(=O)N(C)[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165582
PNG
(US10604504, Example 193 | US9688629, 193 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4N(CCc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O2/c1-4-18(27)26-9-8-13-14(6-5-7-17(13)26)20-16(23)10-15(22(24)28)21-19(20)11(2)12(3)25-21/h4-7,10,25H,1,8-9H2,2-3H3,(H2,24,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164714
PNG
(US10604504, Example 102 | US9688629, 155 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4N(CCOc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O3/c1-4-17(27)26-8-9-29-21-13(6-5-7-16(21)26)19-15(23)10-14(22(24)28)20-18(19)11(2)12(3)25-20/h4-7,10,25H,1,8-9H2,2-3H3,(H2,24,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165348
PNG
(US10604504, Example 132 | US9688629, 132 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CN(Cc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O2/c1-4-18(27)26-9-13-6-5-7-14(16(13)10-26)20-17(23)8-15(22(24)28)21-19(20)11(2)12(3)25-21/h4-8,25H,1,9-10H2,2-3H3,(H2,24,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165577
PNG
(US10604504, Example 191 | US9688629, 189 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cc(F)cc4CN(CCc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H21F2N3O2/c1-4-19(29)28-6-5-15-13(10-28)7-14(24)8-16(15)21-18(25)9-17(23(26)30)22-20(21)11(2)12(3)27-22/h4,7-9,27H,1,5-6,10H2,2-3H3,(H2,26,30)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165509
PNG
(US10604504, Example 166 | US9688629, 165 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CCC4CN(CC34)C(=O)C=C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164714
PNG
(US10604504, Example 102 | US9688629, 155 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4N(CCOc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O3/c1-4-17(27)26-8-9-29-21-13(6-5-7-16(21)26)19-15(23)10-14(22(24)28)20-18(19)11(2)12(3)25-20/h4-7,10,25H,1,8-9H2,2-3H3,(H2,24,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165333
PNG
(US10604504, Example 127 | US9688629, 127 | US98029...)
Show SMILES CCC#CC(=O)N(C)[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12
PDB
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165303
PNG
(US10604504, Example 99 | US9688629, 99 | US9802915...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3ccc4CCCN(C(=O)C=C)c4c3)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22FN3O2/c1-4-19(28)27-9-5-6-14-7-8-15(10-18(14)27)21-17(24)11-16(23(25)29)22-20(21)12(2)13(3)26-22/h4,7-8,10-11,26H,1,5-6,9H2,2-3H3,(H2,25,29)
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n/an/a 0.190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166569
PNG
(US10604504, Example 219 | US9688629, 217 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(C3CCCN(C3)C(=O)C=C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166761
PNG
(US10604504, Example 224 | US9688629, 224 | US98029...)
Show SMILES Cc1[nH]c2c(cc(I)c(-c3cccc4CN(CCc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22IN3O2/c1-4-19(28)27-9-8-15-14(11-27)6-5-7-16(15)21-18(24)10-17(23(25)29)22-20(21)12(2)13(3)26-22/h4-7,10,26H,1,8-9,11H2,2-3H3,(H2,25,29)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM352312
PNG
((R)-4-(3-(but-2- ynamido)piperidin-1-yl)- 5-fluoro...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CCC[C@H](C3)NC(=O)C#C)c2c1C)C(N)=O
PDB
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166824
PNG
(US10604504, Example 264 | US9688629, 239 | US96886...)
Show SMILES Cc1[nH]c2c(cc(Cl)c(-c3cccc4CN(CCc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C23H22ClN3O2/c1-4-19(28)27-9-8-15-14(11-27)6-5-7-16(15)21-18(24)10-17(23(25)29)22-20(21)12(2)13(3)26-22/h4-7,10,26H,1,8-9,11H2,2-3H3,(H2,25,29)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166565
PNG
(US10604504, Example 216 | US9688629, 216 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(C3=CCCN(C3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C19H20FN3O2/c1-4-15(24)23-7-5-6-12(9-23)17-14(20)8-13(19(21)25)18-16(17)10(2)11(3)22-18/h4,6,8,22H,1,5,7,9H2,2-3H3,(H2,21,25)
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n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166011
PNG
(US10604504, Example 211 | US9688629, 209 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4CN(CCc34)C(=O)C=C)c2c1C1CC1)C(N)=O
Show InChI InChI=1S/C25H24FN3O2/c1-3-20(30)29-10-9-16-15(12-29)5-4-6-17(16)22-19(26)11-18(25(27)31)24-23(22)21(13(2)28-24)14-7-8-14/h3-6,11,14,28H,1,7-10,12H2,2H3,(H2,27,31)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165481
PNG
(US10604504, Example 145 | US9688629, 146 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(N3CCC[C@@H](C3)NS(=O)(=O)C=C)c2c1C)C(N)=O
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM166787
PNG
(US10604504, Example 234 | US9688629, 234 | US98029...)
Show SMILES Cc1[nH]c2c(cc(F)c(C3=CCN(C3)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C18H18FN3O2/c1-4-14(23)22-6-5-11(8-22)16-13(19)7-12(18(20)24)17-15(16)9(2)10(3)21-17/h4-5,7,21H,1,6,8H2,2-3H3,(H2,20,24)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164808
PNG
(US10604504, Example 5 | US9688629, 5 | US9802915, ...)
Show SMILES Cc1[nH]c2c(ccc(-c3cccc(NC(=O)C=C)c3C)c2c1C)C(N)=O
Show InChI InChI=1S/C21H21N3O2/c1-5-18(25)24-17-8-6-7-14(12(17)3)15-9-10-16(21(22)26)20-19(15)11(2)13(4)23-20/h5-10,23H,1H2,2-4H3,(H2,22,26)(H,24,25)
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n/an/a 0.210n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165343
PNG
(US10604504, Example 130 | US9688629, 130 | US98029...)
Show SMILES CCN([C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12)C(=O)C#CC
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM164959
PNG
(US10604504, Example 29 | US9688629, 29 | US9802915...)
Show SMILES CN(C(=O)C=C)c1cccc(c1)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12
Show InChI InChI=1S/C21H21N3O2/c1-5-18(25)24(4)15-8-6-7-14(11-15)16-9-10-17(21(22)26)20-19(16)12(2)13(3)23-20/h5-11,23H,1H2,2-4H3,(H2,22,26)
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n/an/a 0.230n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM165583
PNG
(US10604504, Example 196 | US9688629, 194 | US96886...)
Show SMILES Cc1[nH]c2c(cc(F)c(-c3cccc4N(CCSc34)C(=O)C=C)c2c1C)C(N)=O
Show InChI InChI=1S/C22H20FN3O2S/c1-4-17(27)26-8-9-29-21-13(6-5-7-16(21)26)19-15(23)10-14(22(24)28)20-18(19)11(2)12(3)25-20/h4-7,10,25H,1,8-9H2,2-3H3,(H2,24,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9802915 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8H17
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 262 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%