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Patent code US9802918

Compile Data Set for Download or QSAR

Found 324 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352031
PNG
(3-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1
Show InChI InChI=1S/C27H30F3N5O2/c1-16-8-18(31)14-35(13-16)24-4-6-32-12-23(24)33-11-19-2-3-20(28)26(34-19)25-21(29)9-17(10-22(25)30)27(36)5-7-37-15-27/h2-4,6,9-10,12,16,18,33,36H,5,7-8,11,13-15,31H2,1H3/t16-,18+,27?/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352034
PNG
(4-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1S/C28H32F3N5O2/c1-17-10-19(32)16-36(15-17)25-4-7-33-14-24(25)34-13-20-2-3-21(29)27(35-20)26-22(30)11-18(12-23(26)31)28(37)5-8-38-9-6-28/h2-4,7,11-12,14,17,19,34,37H,5-6,8-10,13,15-16,32H2,1H3/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352078
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CC1
Show InChI InChI=1S/C26H28F3N5O/c1-15-8-17(30)14-34(13-15)23-4-7-31-12-22(23)32-11-18-2-3-19(27)25(33-18)24-20(28)9-16(10-21(24)29)26(35)5-6-26/h2-4,7,9-10,12,15,17,32,35H,5-6,8,11,13-14,30H2,1H3/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352081
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CC(C)(C)O)cc1F
Show InChI InChI=1S/C27H32F3N5O/c1-16-8-18(31)15-35(14-16)24-6-7-32-13-23(24)33-12-19-4-5-20(28)26(34-19)25-21(29)9-17(10-22(25)30)11-27(2,3)36/h4-7,9-10,13,16,18,33,36H,8,11-12,14-15,31H2,1-3H3/t16-,18+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352082
PNG
((3R,4R,5S)-3-Amino-1-[3-({[6-(2,6-difluorophenyl)-...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F3N5O/c1-13-11-31(12-18(27)23(13)32)20-7-8-28-10-19(20)29-9-14-5-6-17(26)22(30-14)21-15(24)3-2-4-16(21)25/h2-8,10,13,18,23,29,32H,9,11-12,27H2,1H3/t13-,18+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352083
PNG
((3R,4R,5S)-3-Amino-1-(3-(((5-fluoro-6-(2-fluoro-6-...)
Show SMILES COc1cccc(F)c1-c1nc(CNc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)ccc1F
Show InChI InChI=1S/C24H27F2N5O2/c1-14-12-31(13-18(27)24(14)32)20-8-9-28-11-19(20)29-10-15-6-7-17(26)23(30-15)22-16(25)4-3-5-21(22)33-2/h3-9,11,14,18,24,29,32H,10,12-13,27H2,1-2H3/t14-,18+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352084
PNG
((3R,4R,5S)-3-Amino-5-methyl-1-(3-(((3,3′,5&#...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cncc1F
Show InChI InChI=1S/C22H23F3N6O/c1-12-10-31(11-17(26)22(12)32)19-4-5-27-9-18(19)29-6-13-2-3-14(23)21(30-13)20-15(24)7-28-8-16(20)25/h2-5,7-9,12,17,22,29,32H,6,10-11,26H2,1H3/t12-,17+,22+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352085
PNG
(2-(6-((4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpip...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1C#N
Show InChI InChI=1S/C24H24F2N6O/c1-14-12-32(13-19(28)24(14)33)21-7-8-29-11-20(21)30-10-16-5-6-18(26)23(31-16)22-15(9-27)3-2-4-17(22)25/h2-8,11,14,19,24,30,33H,10,12-13,28H2,1H3/t14-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352087
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F3N5/c1-14-9-15(27)13-31(12-14)21-7-8-28-11-20(21)29-10-16-5-6-19(26)23(30-16)22-17(24)3-2-4-18(22)25/h2-8,11,14-15,29H,9-10,12-13,27H2,1H3/t14-,15+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352089
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((3,3...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cncc1F
Show InChI InChI=1S/C22H23F3N6/c1-13-6-14(26)12-31(11-13)20-4-5-27-10-19(20)29-7-15-2-3-16(23)22(30-15)21-17(24)8-28-9-18(21)25/h2-5,8-10,13-14,29H,6-7,11-12,26H2,1H3/t13-,14+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352094
PNG
(2-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N
Show InChI InChI=1S/C27H29F3N6/c1-16-8-18(32)14-36(13-16)24-6-7-33-12-23(24)34-11-19-4-5-20(28)26(35-19)25-21(29)9-17(10-22(25)30)27(2,3)15-31/h4-7,9-10,12,16,18,34H,8,11,13-14,32H2,1-3H3/t16-,18+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352095
PNG
((3R,4R,5S)-3-Amino-5-methyl-1-(3-{[(2′,6,6&#...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H24F3N5O/c1-13-11-31(12-18(27)23(13)32)20-7-8-28-10-19(20)29-9-14-5-6-17(26)22(30-14)21-15(24)3-2-4-16(21)25/h2-8,10,13,18,23,29,32H,9,11-12,27H2,1H3/t13-,18+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352096
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-[(2&#...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(c1)-c1c(F)cccc1F
Show InChI InChI=1S/C24H25F3N4/c1-15-9-17(28)14-31(13-15)23-7-8-29-12-22(23)30-11-16-5-6-19(25)18(10-16)24-20(26)3-2-4-21(24)27/h2-8,10,12,15,17,30H,9,11,13-14,28H2,1H3/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352100
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1cccc(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H25F2N5/c1-15-10-16(26)14-30(13-15)22-8-9-27-12-21(22)28-11-17-4-2-7-20(29-17)23-18(24)5-3-6-19(23)25/h2-9,12,15-16,28H,10-11,13-14,26H2,1H3/t15-,16+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352104
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CCOCC1
Show InChI InChI=1S/C27H31F3N6O/c1-17-10-18(31)16-36(15-17)25-4-5-32-14-24(25)33-13-19-2-3-21(28)27(34-19)26-22(29)11-20(12-23(26)30)35-6-8-37-9-7-35/h2-5,11-12,14,17-18,33H,6-10,13,15-16,31H2,1H3/t17-,18+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352106
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(hydr...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CO)cc1F
Show InChI InChI=1S/C24H26F3N5O2/c1-13-10-32(11-19(28)24(13)34)21-4-5-29-9-20(21)30-8-15-2-3-16(25)23(31-15)22-17(26)6-14(12-33)7-18(22)27/h2-7,9,13,19,24,30,33-34H,8,10-12,28H2,1H3/t13-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352107
PNG
((4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CO)cc1F
Show InChI InChI=1S/C24H26F3N5O/c1-14-6-16(28)12-32(11-14)22-4-5-29-10-21(22)30-9-17-2-3-18(25)24(31-17)23-19(26)7-15(13-33)8-20(23)27/h2-5,7-8,10,14,16,30,33H,6,9,11-13,28H2,1H3/t14-,16+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352111
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-((met...)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)ccc1F
Show InChI InChI=1S/C25H29F3N6O/c1-14-12-34(13-20(29)25(14)35)22-5-6-31-11-21(22)32-10-16-3-4-17(26)24(33-16)23-18(27)7-15(9-30-2)8-19(23)28/h3-8,11,14,20,25,30,32,35H,9-10,12-13,29H2,1-2H3/t14-,20+,25+/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352118
PNG
((3R,4R,5S)-3-amino-1-(3-(((6-(2,6-difluoro-4-(((S)...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@H](F)C2)cc1F
Show InChI InChI=1S/C28H32F4N6O/c1-16-12-38(15-23(33)28(16)39)25-4-6-34-11-24(25)35-10-19-2-3-20(30)27(36-19)26-21(31)8-17(9-22(26)32)13-37-7-5-18(29)14-37/h2-4,6,8-9,11,16,18,23,28,35,39H,5,7,10,12-15,33H2,1H3/t16-,18-,23+,28+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352120
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1S/C25H29F3N6/c1-15-7-17(29)14-34(13-15)23-5-6-31-12-22(23)32-11-18-3-4-19(26)25(33-18)24-20(27)8-16(10-30-2)9-21(24)28/h3-6,8-9,12,15,17,30,32H,7,10-11,13-14,29H2,1-2H3/t15-,17+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352121
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CCC2)cc1F
Show InChI InChI=1S/C27H31F3N6/c1-17-9-19(31)16-36(14-17)25-5-6-32-13-24(25)33-12-20-3-4-21(28)27(34-20)26-22(29)10-18(11-23(26)30)15-35-7-2-8-35/h3-6,10-11,13,17,19,33H,2,7-9,12,14-16,31H2,1H3/t17-,19+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352130
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(4-me...)
Show SMILES COC1(CCOCC1)c1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)ccc1F
Show InChI InChI=1S/C29H34F3N5O3/c1-17-15-37(16-23(33)28(17)38)25-5-8-34-14-24(25)35-13-19-3-4-20(30)27(36-19)26-21(31)11-18(12-22(26)32)29(39-2)6-9-40-10-7-29/h3-5,8,11-12,14,17,23,28,35,38H,6-7,9-10,13,15-16,33H2,1-2H3/t17-,23+,28+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352131
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-({6-[...)
Show SMILES COC1(CCOCC1)c1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1S/C29H34F3N5O2/c1-18-11-20(33)17-37(16-18)26-5-8-34-15-25(26)35-14-21-3-4-22(30)28(36-21)27-23(31)12-19(13-24(27)32)29(38-2)6-9-39-10-7-29/h3-5,8,12-13,15,18,20,35H,6-7,9-11,14,16-17,33H2,1-2H3/t18-,20+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352136
PNG
(4-((3S,5R)-3-Amino-5-(trifluoromethyl)piperidin-1-...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C28H29F6N5O/c29-21-2-1-20(38-27(21)26-22(30)9-17(10-23(26)31)16-4-7-40-8-5-16)12-37-24-13-36-6-3-25(24)39-14-18(28(32,33)34)11-19(35)15-39/h1-3,6,9-10,13,16,18-19,37H,4-5,7-8,11-12,14-15,35H2/t18-,19+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352137
PNG
(4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-N-{[6-(2...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C24H25F3N4/c1-14-9-15(11-16(28)10-14)18-7-8-29-13-22(18)30-12-17-5-6-21(27)24(31-17)23-19(25)3-2-4-20(23)26/h2-8,13-16,30H,9-12,28H2,1H3/t14-,15+,16-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352138
PNG
(1-(4-{6-[({4-[(1R,3S,5S)-3-Amino-5-methylcyclohexy...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1S/C28H31F3N4O/c1-16-9-17(11-19(32)10-16)21-5-8-33-15-25(21)34-14-20-3-4-22(29)27(35-20)26-23(30)12-18(13-24(26)31)28(36)6-2-7-28/h3-5,8,12-13,15-17,19,34,36H,2,6-7,9-11,14,32H2,1H3/t16-,17+,19-/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352139
PNG
(4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-N-{[6-(2...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CCOCC1
Show InChI InChI=1S/C28H32F3N5O/c1-17-10-18(12-19(32)11-17)22-4-5-33-16-26(22)34-15-20-2-3-23(29)28(35-20)27-24(30)13-21(14-25(27)31)36-6-8-37-9-7-36/h2-5,13-14,16-19,34H,6-12,15,32H2,1H3/t17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352139
PNG
(4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-N-{[6-(2...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CCOCC1
Show InChI InChI=1S/C28H32F3N5O/c1-17-10-18(12-19(32)11-17)22-4-5-33-16-26(22)34-15-20-2-3-23(29)28(35-20)27-24(30)13-21(14-25(27)31)36-6-8-37-9-7-36/h2-5,13-14,16-19,34H,6-12,15,32H2,1H3/t17-,18+,19-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352141
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-[(6-{...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CC[C@@H](F)C1
Show InChI InChI=1S/C27H30F4N6/c1-16-8-18(32)15-37(13-16)25-4-6-33-12-24(25)34-11-19-2-3-21(29)27(35-19)26-22(30)9-20(10-23(26)31)36-7-5-17(28)14-36/h2-4,6,9-10,12,16-18,34H,5,7-8,11,13-15,32H2,1H3/t16-,17-,18+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352142
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-({6-[...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CCCC(F)C1
Show InChI InChI=1S/C28H32F4N6/c1-17-9-19(33)16-38(14-17)26-6-7-34-13-25(26)35-12-20-4-5-22(30)28(36-20)27-23(31)10-21(11-24(27)32)37-8-2-3-18(29)15-37/h4-7,10-11,13,17-19,35H,2-3,8-9,12,14-16,33H2,1H3/t17-,18?,19+/m1/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352143
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CC(C)(O)C1
Show InChI InChI=1S/C27H31F3N6O/c1-16-7-17(31)13-35(12-16)24-5-6-32-11-23(24)33-10-18-3-4-20(28)26(34-18)25-21(29)8-19(9-22(25)30)36-14-27(2,37)15-36/h3-6,8-9,11,16-17,33,37H,7,10,12-15,31H2,1-2H3/t16-,17+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352143
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CC(C)(O)C1
Show InChI InChI=1S/C27H31F3N6O/c1-16-7-17(31)13-35(12-16)24-5-6-32-11-23(24)33-10-18-3-4-20(28)26(34-18)25-21(29)8-19(9-22(25)30)36-14-27(2,37)15-36/h3-6,8-9,11,16-17,33,37H,7,10,12-15,31H2,1-2H3/t16-,17+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352144
PNG
((3R,4R,5S)-3-Amino-1-(3-{[(6-{2,6-difluoro-4-[(3R)...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(O[C@@H]2CCOC2)cc1F
Show InChI InChI=1S/C27H30F3N5O3/c1-15-12-35(13-22(31)27(15)36)24-4-6-32-11-23(24)33-10-16-2-3-19(28)26(34-16)25-20(29)8-18(9-21(25)30)38-17-5-7-37-14-17/h2-4,6,8-9,11,15,17,22,27,33,36H,5,7,10,12-14,31H2,1H3/t15-,17+,22+,27+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352145
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-[(6-{...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(O[C@@H]2CCOC2)cc1F
Show InChI InChI=1S/C27H30F3N5O2/c1-16-8-17(31)14-35(13-16)25-4-6-32-12-24(25)33-11-18-2-3-21(28)27(34-18)26-22(29)9-20(10-23(26)30)37-19-5-7-36-15-19/h2-4,6,9-10,12,16-17,19,33H,5,7-8,11,13-15,31H2,1H3/t16-,17+,19-/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352151
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES COc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1S/C24H26F3N5O/c1-14-7-15(28)13-32(12-14)22-5-6-29-11-21(22)30-10-16-3-4-18(25)24(31-16)23-19(26)8-17(33-2)9-20(23)27/h3-6,8-9,11,14-15,30H,7,10,12-13,28H2,1-2H3/t14-,15+/m1/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352151
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES COc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1S/C24H26F3N5O/c1-14-7-15(28)13-32(12-14)22-5-6-29-11-21(22)30-10-16-3-4-18(25)24(31-16)23-19(26)8-17(33-2)9-20(23)27/h3-6,8-9,11,14-15,30H,7,10,12-13,28H2,1-2H3/t14-,15+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352152
PNG
(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1ccc(cc1F)C#N
Show InChI InChI=1S/C24H24F2N6/c1-15-8-17(28)14-32(13-15)23-6-7-29-12-22(23)30-11-18-3-5-20(25)24(31-18)19-4-2-16(10-27)9-21(19)26/h2-7,9,12,15,17,30H,8,11,13-14,28H2,1H3/t15-,17+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352153
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1ccc2sccc2c1
Show InChI InChI=1S/C25H26FN5S/c1-16-10-19(27)15-31(14-16)23-6-8-28-13-22(23)29-12-20-3-4-21(26)25(30-20)18-2-5-24-17(11-18)7-9-32-24/h2-9,11,13,16,19,29H,10,12,14-15,27H2,1H3/t16-,19+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352156
PNG
((3R,4R,5S)-3-Amino-1-[5-({[6-(2,6-difluorophenyl)-...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCOc2ncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C25H26F3N5O2/c1-13-11-33(12-19(29)24(13)34)23-15-7-8-35-25(15)31-10-20(23)30-9-14-5-6-18(28)22(32-14)21-16(26)3-2-4-17(21)27/h2-6,10,13,19,24,30,34H,7-9,11-12,29H2,1H3/t13-,19+,24+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352157
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCCc2ncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H28F3N5/c1-15-10-16(30)14-34(13-15)26-18-4-2-7-22(18)32-12-23(26)31-11-17-8-9-21(29)25(33-17)24-19(27)5-3-6-20(24)28/h3,5-6,8-9,12,15-16,31H,2,4,7,10-11,13-14,30H2,1H3/t15-,16+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352158
PNG
(4-[(3R,4R)-3-Amino-4-fluoropiperidin-1-yl]-N-{[6-(...)
Show SMILES N[C@@H]1CN(CC[C@H]1F)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C22H21F4N5/c23-14-7-9-31(12-18(14)27)20-6-8-28-11-19(20)29-10-13-4-5-17(26)22(30-13)21-15(24)2-1-3-16(21)25/h1-6,8,11,14,18,29H,7,9-10,12,27H2/t14-,18-/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352159
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[7-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc2ccc(cc2n1)-c1ccc2CCOc2c1
Show InChI InChI=1S/C29H31N5O/c1-19-12-24(30)18-34(17-19)28-8-10-31-16-27(28)32-15-25-7-6-20-2-4-22(13-26(20)33-25)23-5-3-21-9-11-35-29(21)14-23/h2-8,10,13-14,16,19,24,32H,9,11-12,15,17-18,30H2,1H3/t19-,24+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352168
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(OCC(C)(C)O)cc1F
Show InChI InChI=1S/C27H32F3N5O2/c1-16-8-17(31)14-35(13-16)24-6-7-32-12-23(24)33-11-18-4-5-20(28)26(34-18)25-21(29)9-19(10-22(25)30)37-15-27(2,3)36/h4-7,9-10,12,16-17,33,36H,8,11,13-15,31H2,1-3H3/t16-,17+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352171
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(1-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)O
Show InChI InChI=1S/C26H30F3N5O2/c1-14-12-34(13-20(30)25(14)35)22-6-7-31-11-21(22)32-10-16-4-5-17(27)24(33-16)23-18(28)8-15(9-19(23)29)26(2,3)36/h4-9,11,14,20,25,32,35-36H,10,12-13,30H2,1-3H3/t14-,20+,25+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352172
PNG
(4-{2-[({4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpi...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc2ccc(cc2n1)-c1ccn(C)c(=O)c1F
Show InChI InChI=1S/C27H29FN6O2/c1-16-14-34(15-21(29)26(16)35)24-7-9-30-13-23(24)31-12-19-6-5-17-3-4-18(11-22(17)32-19)20-8-10-33(2)27(36)25(20)28/h3-11,13,16,21,26,31,35H,12,14-15,29H2,1-2H3/t16-,21+,26+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352020
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(3-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1
Show InChI InChI=1S/C27H30F3N5O3/c1-15-12-35(13-21(31)26(15)36)23-4-6-32-11-22(23)33-10-17-2-3-18(28)25(34-17)24-19(29)8-16(9-20(24)30)27(37)5-7-38-14-27/h2-4,6,8-9,11,15,21,26,33,36-37H,5,7,10,12-14,31H2,1H3/t15-,21+,26+,27?/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352030
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(4-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1S/C28H32F3N5O3/c1-16-14-36(15-22(32)27(16)37)24-4-7-33-13-23(24)34-12-18-2-3-19(29)26(35-18)25-20(30)10-17(11-21(25)31)28(38)5-8-39-9-6-28/h2-4,7,10-11,13,16,22,27,34,37-38H,5-6,8-9,12,14-15,32H2,1H3/t16-,22+,27+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352030
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(4-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1S/C28H32F3N5O3/c1-16-14-36(15-22(32)27(16)37)24-4-7-33-13-23(24)34-12-18-2-3-19(29)26(35-18)25-20(30)10-17(11-21(25)31)28(38)5-8-39-9-6-28/h2-4,7,10-11,13,16,22,27,34,37-38H,5-6,8-9,12,14-15,32H2,1H3/t16-,22+,27+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352031
PNG
(3-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1
Show InChI InChI=1S/C27H30F3N5O2/c1-16-8-18(31)14-35(13-16)24-4-6-32-12-23(24)33-11-19-2-3-20(28)26(34-19)25-21(29)9-17(10-22(25)30)27(36)5-7-37-15-27/h2-4,6,9-10,12,16,18,33,36H,5,7-8,11,13-15,31H2,1H3/t16-,18+,27?/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352033
PNG
(1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1S/C27H30F3N5O/c1-16-9-18(31)15-35(14-16)24-5-8-32-13-23(24)33-12-19-3-4-20(28)26(34-19)25-21(29)10-17(11-22(25)30)27(36)6-2-7-27/h3-5,8,10-11,13,16,18,33,36H,2,6-7,9,12,14-15,31H2,1H3/t16-,18+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%