Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352621 ((R)-tert-butyl (2-(2- (oxazolidin-3-yl)-2- oxoethy...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 1.96 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352909 (US9809561, 115A) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.03 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352646 ((S)-neopentyl (2-(2- (methylamino)-2- oxoethyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.11 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352591 ((S)-methyl 2-(6-((tert- butoxycarbonyl)amino)-4-((...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.15 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352589 ((S)-methyl 2-(6-((tert- butoxycarbonyl)amino)-4-((...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.24 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352725 (US9809561, 49 | tert-butyl (2-(cyanomethyl)-4-((3-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.46 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352638 ((S)-methyl 3-(2-(6-((tert- butoxycarbonyl) amino)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.53 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352645 ((S)-tert-butyl (2-(2- (oxazolidin-3-yl)-2- oxoethy...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.56 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352512 ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-flu...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.72 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352785 ((S)-tert-butyl (2-((2H-1,2,3-triazol-2- yl)methyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.78 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352784 ((S)-tert-butyl (2-((1H-1,2,3-triazol-1- yl)methyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352619 ((S)-tert-butyl (4-((3-chloro-4- fluorophenyl) sul...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 2.81 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352481 ((R)-tert-butyl (2-(hydroxymethyl)-4-((3-(trifluoro...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.01 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352782 ((S)-tert-butyl (2-((1H-1,2,4-triazol-1- yl)methyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.04 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352537 ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((3,4-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.04 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352849 (US9809561, 92) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.11 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352748 ((S)-tert-butyl (2-(2-acetamido-2- methylpropyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.13 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352590 ((S)-methyl 2-(6-((tert- butoxycarbonyl)amino)-4-((...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.13 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352552 ((R)-tert-butyl (2-((pyridin-2-ylsulfonyl)methyl)-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.28 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352821 (1,1,1-trifluoro-2-methylpropan-2-yl ((R or S)-4-((...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.33 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352744 ((R)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-(2-o...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.42 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352908 (2,2,2-trifluoro-1,1- dimethylethyl (1-{[2- (triflu...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.46 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352746 ((S)-tert-butyl (2-(2-acetamido-2-methylpropyl)-4-(...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.49 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352775 (US9809561, 58 | tert-butyl (2-(2-hydroxyethyl)-4-(...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.56 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352613 ((S)-tert-butyl (2-(2- amino-2-oxoethyl)-4- ((3-(tr...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.66 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352588 ((S)-methyl 2-(6-((tert-butoxycarbonyl)amino)-4-((3...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.76 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352629 ((S)-tert-butyl (2-(2- oxo-2-((pyrazolo[1,5- a]pyri...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.79 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352558 ((R)-tert-butyl (2- ((methylsulfonyl)methyl)-4-((3-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.86 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352905 (2,2,2-trifluoro-1,1- dimethylethyl {l-[(3- chloro-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.87 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352612 ((S)-tert-butyl (2-(2- amino-2-oxoethyl)-4- ((4-flu...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.89 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352540 ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((3-chl...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.92 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352544 ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((2-met...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.93 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352755 ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-acet...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 3.99 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352700 ((S)-(2-(2-(methoxyamino)-2-oxoethyl)-4-((3-(triflu...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.07 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352729 ((S)-tert-butyl (2-(2-propionamidoethyl)-4- ((3-(tr...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.07 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352752 ((R)-tert-butyl (2-(2-acetamido-2- methylpropyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.09 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352545 ((R)-tert-butyl (2-((pyridin-2-ylthio)methyl)-4-((3...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.13 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352552 ((R)-tert-butyl (2-((pyridin-2-ylsulfonyl)methyl)-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.16 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352644 ((S)-tert-butyl (2-(2-(ethylamino)-2- oxoethyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.16 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352758 ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-acet...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.17 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352906 (2,2,2-trifluoro-1,1- dimethylethyl (1-{[1-ethyl- 3...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.19 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352499 (US9809561, 9) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.23 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352643 ((S)-tert-butyl (2-(2-oxo-2- (propylamino) ethyl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.38 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352733 ((S)-tert-butyl (2-(2-acetamidoethyl)-4-((3- (trifl...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.38 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352630 ((S)-tert-butyl (2- (2-(((1-ethyl-1H- pyrazol-3-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.47 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352918 (US9809561, 119) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.49 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352859 ((S)-1,1,1-trifluoro-2- methylpropan-2-yl (2-(2-cya...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.52 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352757 ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-flu...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.52 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352484 (US9809561, 2C | [(R)-4-(3-chloro-benzenesulfonyl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.57 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM352789 ( tert-butyl (2-(2-hydroxy-2-methylpropyl)-4-((3-(t...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 4.57 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.; LYCERA CORPORATION US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) Article DOI: 10.1016/j.bmcl.2006.03.041 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Displayed 1 to 50 (of 424 total ) | Next | Last >> |
