Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352621![]() ((R)-tert-butyl (2-(2- (oxazolidin-3-yl)-2- oxoethy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.96 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352909![]() (US9809561, 115A) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.03 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352646![]() ((S)-neopentyl (2-(2- (methylamino)-2- oxoethyl)-4-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352591![]() ((S)-methyl 2-(6-((tert- butoxycarbonyl)amino)-4-((...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352589![]() ((S)-methyl 2-(6-((tert- butoxycarbonyl)amino)-4-((...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.24 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352725![]() (US9809561, 49 | tert-butyl (2-(cyanomethyl)-4-((3-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352638![]() ((S)-methyl 3-(2-(6-((tert- butoxycarbonyl) amino)-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.53 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352645![]() ((S)-tert-butyl (2-(2- (oxazolidin-3-yl)-2- oxoethy...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.56 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352512![]() ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-flu...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.72 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352785![]() ((S)-tert-butyl (2-((2H-1,2,3-triazol-2- yl)methyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.78 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352784![]() ((S)-tert-butyl (2-((1H-1,2,3-triazol-1- yl)methyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352619![]() ((S)-tert-butyl (4-((3-chloro-4- fluorophenyl) sul...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.81 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352481![]() ((R)-tert-butyl (2-(hydroxymethyl)-4-((3-(trifluoro...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.01 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352782![]() ((S)-tert-butyl (2-((1H-1,2,4-triazol-1- yl)methyl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.04 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352537![]() ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((3,4-d...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.04 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352849![]() (US9809561, 92) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352748![]() ((S)-tert-butyl (2-(2-acetamido-2- methylpropyl)-4-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352590![]() ((S)-methyl 2-(6-((tert- butoxycarbonyl)amino)-4-((...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352552![]() ((R)-tert-butyl (2-((pyridin-2-ylsulfonyl)methyl)-4...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352821![]() (1,1,1-trifluoro-2-methylpropan-2-yl ((R or S)-4-((...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.33 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352744![]() ((R)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-(2-o...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.42 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352908![]() (2,2,2-trifluoro-1,1- dimethylethyl (1-{[2- (triflu...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352746![]() ((S)-tert-butyl (2-(2-acetamido-2-methylpropyl)-4-(...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.49 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352775![]() (US9809561, 58 | tert-butyl (2-(2-hydroxyethyl)-4-(...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.56 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352613![]() ((S)-tert-butyl (2-(2- amino-2-oxoethyl)-4- ((3-(tr...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.66 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352588![]() ((S)-methyl 2-(6-((tert-butoxycarbonyl)amino)-4-((3...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.76 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352629![]() ((S)-tert-butyl (2-(2- oxo-2-((pyrazolo[1,5- a]pyri...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.79 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352558![]() ((R)-tert-butyl (2- ((methylsulfonyl)methyl)-4-((3-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.86 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352905![]() (2,2,2-trifluoro-1,1- dimethylethyl {l-[(3- chloro-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.87 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352612![]() ((S)-tert-butyl (2-(2- amino-2-oxoethyl)-4- ((4-flu...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.89 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352540![]() ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((3-chl...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.92 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352544![]() ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((2-met...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.93 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352755![]() ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-acet...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.99 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352700![]() ((S)-(2-(2-(methoxyamino)-2-oxoethyl)-4-((3-(triflu...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.07 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352729![]() ((S)-tert-butyl (2-(2-propionamidoethyl)-4- ((3-(tr...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.07 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352752![]() ((R)-tert-butyl (2-(2-acetamido-2- methylpropyl)-4-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.09 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352545![]() ((R)-tert-butyl (2-((pyridin-2-ylthio)methyl)-4-((3...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352644![]() ((S)-tert-butyl (2-(2-(ethylamino)-2- oxoethyl)-4-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352552![]() ((R)-tert-butyl (2-((pyridin-2-ylsulfonyl)methyl)-4...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352758![]() ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-acet...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.17 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352906![]() (2,2,2-trifluoro-1,1- dimethylethyl (1-{[1-ethyl- 3...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352499![]() (US9809561, 9) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352643![]() ((S)-tert-butyl (2-(2-oxo-2- (propylamino) ethyl)-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.38 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352733![]() ((S)-tert-butyl (2-(2-acetamidoethyl)-4-((3- (trifl...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.38 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352630![]() ((S)-tert-butyl (2- (2-(((1-ethyl-1H- pyrazol-3-yl)...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.47 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352918![]() (US9809561, 119) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.49 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352859![]() ((S)-1,1,1-trifluoro-2- methylpropan-2-yl (2-(2-cya...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.52 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352757![]() ((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-flu...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.52 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352484![]() (US9809561, 2C | [(R)-4-(3-chloro-benzenesulfonyl)-...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.57 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM352789![]() ( tert-butyl (2-(2-hydroxy-2-methylpropyl)-4-((3-(t...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.57 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp US Patent | Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay.... | US Patent US9809561 (2017) BindingDB Entry DOI: 10.7270/Q20Z75DC | |||||||||||
More data for this Ligand-Target Pair |
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