BindingDB logo
myBDB logout

Patent code US9815819

Compile Data Set for Download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Complement factor D


(Homo sapiens (Human))		BDBM355665
PNG
(1-(2-{(1R,3S,5S)-3-[(1R,2S)-2-(2-Chloro-phenyl)-cy...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2Cl)c2ccccc12
Show InChI InChI=1S/C26H26ClN5O4/c27-17-7-3-1-5-14(17)16-9-18(16)29-25(36)20-10-26(13-33)11-21(26)32(20)22(34)12-31-19-8-4-2-6-15(19)23(30-31)24(28)35/h1-8,16,18,20-21,33H,9-13H2,(H2,28,35)(H,29,36)/t16-,18+,20-,21+,26-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355637
PNG
((1R,3S,5R)-2-[2-(3-Acetyl-indazol-1- yl)-acetyl]-2...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H26N4O3/c1-15(31)25-18-9-5-6-10-21(18)29(28-25)14-24(32)30-22-11-17(22)12-23(30)26(33)27-20-13-19(20)16-7-3-2-4-8-16/h2-10,17,19-20,22-23H,11-14H2,1H3,(H,27,33)/t17-,19+,20-,22-,23+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355700
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2Cl)c2cnccc12
Show InChI InChI=1S/C25H24ClN5O3/c1-13(32)24-16-6-7-27-11-22(16)30(29-24)12-23(33)31-20-8-14(20)9-21(31)25(34)28-19-10-17(19)15-4-2-3-5-18(15)26/h2-7,11,14,17,19-21H,8-10,12H2,1H3,(H,28,34)/t14-,17+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355683
PNG
(1-{2-[(1R,3S,5R)-3-((1R,2R)-2- Fluoro-2-phenyl- cy...)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@@]3(F)c3ccccc3)c2cn1)C(N)=O
Show InChI InChI=1S/C25H25FN6O3/c1-13-7-16-19(11-28-13)31(30-22(16)23(27)34)12-21(33)32-17-8-14(17)9-18(32)24(35)29-20-10-25(20,26)15-5-3-2-4-6-15/h2-7,11,14,17-18,20H,8-10,12H2,1H3,(H2,27,34)(H,29,35)/t14-,17-,18+,20-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355654
PNG
(5-Ethyl-1-{2-oxo-2-[(1R,3S,5R)-3- ((1R,2S)-2-pheny...)
Show SMILES CCc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3)c2cn1)C(N)=O
Show InChI InChI=1S/C26H28N6O3/c1-2-16-10-18-22(12-28-16)31(30-24(18)25(27)34)13-23(33)32-20-8-15(20)9-21(32)26(35)29-19-11-17(19)14-6-4-3-5-7-14/h3-7,10,12,15,17,19-21H,2,8-9,11,13H2,1H3,(H2,27,34)(H,29,35)/t15-,17+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355681
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@]2(F)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C25H24FN5O3/c1-14(32)23-17-7-8-27-12-20(17)30(29-23)13-22(33)31-18-9-15(18)10-19(31)24(34)28-21-11-25(21,26)16-5-3-2-4-6-16/h2-8,12,15,18-19,21H,9-11,13H2,1H3,(H,28,34)/t15-,18-,19+,21-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355702
PNG
(1-(2-{(1R,3S,5R)-3-[(1R,2S)-2-(2- Chloro-phenyl)- ...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2Cl)c2cnccc12
Show InChI InChI=1S/C24H23ClN6O3/c25-16-4-2-1-3-13(16)15-9-17(15)28-24(34)19-8-12-7-18(12)31(19)21(32)11-30-20-10-27-6-5-14(20)22(29-30)23(26)33/h1-6,10,12,15,17-19H,7-9,11H2,(H2,26,33)(H,28,34)/t12-,15+,17-,18-,19+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355685
PNG
(1-(2-{(1R,3S,5R)-3-[2-Fluoro-2-(2- fluoro-phenyl)-...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2(F)c2ccccc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-16-7-3-2-6-15(16)25(27)11-20(25)29-24(35)19-10-13-9-18(13)32(19)21(33)12-31-17-8-4-1-5-14(17)22(30-31)23(28)34/h1-8,13,18-20H,9-12H2,(H2,28,34)(H,29,35)/t13-,18-,19+,20?,25?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355709
PNG
(1-(2-{(1R,3S,5R)-3-[2-(2,4- Difluoro-phenyl)- cycl...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2ccc(F)cc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-13-5-6-14(17(27)9-13)16-10-18(16)29-25(35)21-8-12-7-20(12)32(21)22(33)11-31-19-4-2-1-3-15(19)23(30-31)24(28)34/h1-6,9,12,16,18,20-21H,7-8,10-11H2,(H2,28,34)(H,29,35)/t12-,16?,18?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355703
PNG
(1-(2-{(1R,3S,5R)-3-[(1R,2S)-2-(2- Chloro-phenyl)- ...)
Show SMILES CCc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3Cl)c2cn1)C(N)=O
Show InChI InChI=1S/C26H27ClN6O3/c1-2-14-9-17-22(11-29-14)32(31-24(17)25(28)35)12-23(34)33-20-7-13(20)8-21(33)26(36)30-19-10-16(19)15-5-3-4-6-18(15)27/h3-6,9,11,13,16,19-21H,2,7-8,10,12H2,1H3,(H2,28,35)(H,30,36)/t13-,16+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355694
PNG
((2S,4R)-1-[2-(3-Acetyl-indazol-1- yl)-acetyl]-4-fl...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H25FN4O3/c1-15(31)24-18-9-5-6-10-21(18)30(28-24)14-23(32)29-13-17(26)11-22(29)25(33)27-20-12-19(20)16-7-3-2-4-8-16/h2-10,17,19-20,22H,11-14H2,1H3,(H,27,33)/t17-,19+,20-,22+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355666
PNG
((1R,3S,5S)-2-[2-(3-Acetyl-pyrazolo[3,4-c]pyridin-1...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2Cl)c2cnccc12
Show InChI InChI=1S/C26H26ClN5O4/c1-14(34)24-16-6-7-28-11-21(16)31(30-24)12-23(35)32-20(9-26(13-33)10-22(26)32)25(36)29-19-8-17(19)15-4-2-3-5-18(15)27/h2-7,11,17,19-20,22,33H,8-10,12-13H2,1H3,(H,29,36)/t17-,19+,20-,22+,26-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355693
PNG
(1-(2-{(1R,3S,5R)-3-[(1R,2S)-2-(2-Chloro-phenyl)-cy...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2Cl)c2ccccc12
Show InChI InChI=1S/C25H24ClN5O3/c26-17-7-3-1-5-14(17)16-11-18(16)28-25(34)21-10-13-9-20(13)31(21)22(32)12-30-19-8-4-2-6-15(19)23(29-30)24(27)33/h1-8,13,16,18,20-21H,9-12H2,(H2,27,33)(H,28,34)/t13-,16+,18-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355645
PNG
((2S,3S,4S)-1-[2-(3-Acetyl-indazol-1- yl)-acetyl]-4...)
Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)N[C@@H]1C[C@H]1c1ccccc1)C(=O)Cn1nc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C26H27FN4O4/c1-15(32)23-17-10-6-7-11-21(17)31(29-23)14-22(33)30-13-19(27)25(35-2)24(30)26(34)28-20-12-18(20)16-8-4-3-5-9-16/h3-11,18-20,24-25H,12-14H2,1-2H3,(H,28,34)/t18-,19-,20+,24-,25+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355701
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2Cl)c2ncccc12
Show InChI InChI=1S/C25H24ClN5O3/c1-13(32)23-16-6-4-8-27-24(16)30(29-23)12-22(33)31-20-9-14(20)10-21(31)25(34)28-19-11-17(19)15-5-2-3-7-18(15)26/h2-8,14,17,19-21H,9-12H2,1H3,(H,28,34)/t14-,17+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355653
PNG
(1-{2-[(2S,4R)-4-Fluoro-2-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H24FN5O3/c25-15-10-20(24(33)27-18-11-17(18)14-6-2-1-3-7-14)29(12-15)21(31)13-30-19-9-5-4-8-16(19)22(28-30)23(26)32/h1-9,15,17-18,20H,10-13H2,(H2,26,32)(H,27,33)/t15-,17+,18-,20+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355708
PNG
(1-(2-{(1R,3S,5R)-3-[(1R,2S)-2-(2- Chloro-phenyl)- ...)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3Cl)c2cn1)C(N)=O
Show InChI InChI=1S/C25H25ClN6O3/c1-12-6-16-21(10-28-12)31(30-23(16)24(27)34)11-22(33)32-19-7-13(19)8-20(32)25(35)29-18-9-15(18)14-4-2-3-5-17(14)26/h2-6,10,13,15,18-20H,7-9,11H2,1H3,(H2,27,34)(H,29,35)/t13-,15+,18-,19-,20+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355722
PNG
(3-Acetyl-1-(2-{(1R,3S,5R)-3-[(1R,2S)-2-(2-fluoro-p...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2F)c2cc(ccc12)C(O)=O
Show InChI InChI=1S/C27H25FN4O5/c1-13(33)25-17-7-6-14(27(36)37)8-22(17)31(30-25)12-24(34)32-21-9-15(21)10-23(32)26(35)29-20-11-18(20)16-4-2-3-5-19(16)28/h2-8,15,18,20-21,23H,9-12H2,1H3,(H,29,35)(H,36,37)/t15-,18+,20-,21-,23+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355674
PNG
(1-{2-[(1R,3S,5R)-3-((1R,2R)-2-fluoro-2-phenyl-cycl...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@]2(F)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H24FN5O3/c26-25(15-6-2-1-3-7-15)12-20(25)28-24(34)19-11-14-10-18(14)31(19)21(32)13-30-17-9-5-4-8-16(17)22(29-30)23(27)33/h1-9,14,18-20H,10-13H2,(H2,27,33)(H,28,34)/t14-,18-,19+,20-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355647
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H25N5O3/c26-24(32)23-16-8-4-5-9-19(16)29(28-23)13-22(31)30-20-10-15(20)11-21(30)25(33)27-18-12-17(18)14-6-2-1-3-7-14/h1-9,15,17-18,20-21H,10-13H2,(H2,26,32)(H,27,33)/t15-,17+,18-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355661
PNG
(5-Fluoro-1-{2-[(1R,3S,5R)-3- ((1R,2R)-2-fluoro-2-p...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@]2(F)c2ccccc2)c2ccc(F)cc12
Show InChI InChI=1S/C25H23F2N5O3/c26-15-6-7-17-16(10-15)22(23(28)34)30-31(17)12-21(33)32-18-8-13(18)9-19(32)24(35)29-20-11-25(20,27)14-4-2-1-3-5-14/h1-7,10,13,18-20H,8-9,11-12H2,(H2,28,34)(H,29,35)/t13-,18-,19+,20-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355698
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2F)c2ncccc12
Show InChI InChI=1S/C25H24FN5O3/c1-13(32)23-16-6-4-8-27-24(16)30(29-23)12-22(33)31-20-9-14(20)10-21(31)25(34)28-19-11-17(19)15-5-2-3-7-18(15)26/h2-8,14,17,19-21H,9-12H2,1H3,(H,28,34)/t14-,17+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 64n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355644
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C24H24N6O3/c25-23(32)22-15-6-7-26-11-20(15)29(28-22)12-21(31)30-18-8-14(18)9-19(30)24(33)27-17-10-16(17)13-4-2-1-3-5-13/h1-7,11,14,16-19H,8-10,12H2,(H2,25,32)(H,27,33)/t14-,16+,17-,18-,19+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 65n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355679
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@]2(F)c2ccccc2)c2ncccc12
Show InChI InChI=1S/C25H24FN5O3/c1-14(32)22-17-8-5-9-27-23(17)30(29-22)13-21(33)31-18-10-15(18)11-19(31)24(34)28-20-12-25(20,26)16-6-3-2-4-7-16/h2-9,15,18-20H,10-13H2,1H3,(H,28,34)/t15-,18-,19+,20-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 66n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355706
PNG
(1-(2-{(2S,4R)-4-Fluoro-2-[(1R,2S)- 2-(2-fluoro-phe...)
Show SMILES Cc1cc2c(nn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3F)c2cn1)C(N)=O
Show InChI InChI=1S/C24H24F2N6O3/c1-12-6-16-20(9-28-12)32(30-22(16)23(27)34)11-21(33)31-10-13(25)7-19(31)24(35)29-18-8-15(18)14-4-2-3-5-17(14)26/h2-6,9,13,15,18-19H,7-8,10-11H2,1H3,(H2,27,34)(H,29,35)/t13-,15+,18-,19+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355640
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C25H25N5O3/c1-14(31)24-17-7-8-26-12-22(17)29(28-24)13-23(32)30-20-9-16(20)10-21(30)25(33)27-19-11-18(19)15-5-3-2-4-6-15/h2-8,12,16,18-21H,9-11,13H2,1H3,(H,27,33)/t16-,18+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 106n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355691
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2cccc(Cl)c2F)c2ncccc12
Show InChI InChI=1S/C25H23ClFN5O3/c1-12(33)23-15-5-3-7-28-24(15)31(30-23)11-21(34)32-19-8-13(19)9-20(32)25(35)29-18-10-16(18)14-4-2-6-17(26)22(14)27/h2-7,13,16,18-20H,8-11H2,1H3,(H,29,35)/t13-,16+,18-,19-,20+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 109n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355660
PNG
(5,6-Difluoro-1-{2-[(1R,3S,5R)-3- ((1R,2R)-2-fluoro...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@]2(F)c2ccccc2)c2cc(F)c(F)cc12
Show InChI InChI=1S/C25H22F3N5O3/c26-15-8-14-18(9-16(15)27)32(31-22(14)23(29)35)11-21(34)33-17-6-12(17)7-19(33)24(36)30-20-10-25(20,28)13-4-2-1-3-5-13/h1-5,8-9,12,17,19-20H,6-7,10-11H2,(H2,29,35)(H,30,36)/t12-,17-,19+,20-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355669
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2ccc(C)c(C)c2)c2cnccc12
Show InChI InChI=1S/C27H29N5O3/c1-14-4-5-17(8-15(14)2)20-11-21(20)29-27(35)23-10-18-9-22(18)32(23)25(34)13-31-24-12-28-7-6-19(24)26(30-31)16(3)33/h4-8,12,18,20-23H,9-11,13H2,1-3H3,(H,29,35)/t18-,20?,21?,22-,23+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 112n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355713
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-(3- phenyl-cyclohexylcarb...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C28H31N5O3/c29-27(35)26-21-11-4-5-12-22(21)32(31-26)16-25(34)33-23-14-19(23)15-24(33)28(36)30-20-10-6-9-18(13-20)17-7-2-1-3-8-17/h1-5,7-8,11-12,18-20,23-24H,6,9-10,13-16H2,(H2,29,35)(H,30,36)/t18?,19-,20?,23-,24+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 114n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355650
PNG
(5-Methyl-1-{2-oxo-2-[(1R,3S,5R)-3- ((1R,2S)-2-phen...)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3)c2cn1)C(N)=O
Show InChI InChI=1S/C25H26N6O3/c1-13-7-17-21(11-27-13)30(29-23(17)24(26)33)12-22(32)31-19-8-15(19)9-20(31)25(34)28-18-10-16(18)14-5-3-2-4-6-14/h2-7,11,15-16,18-20H,8-10,12H2,1H3,(H2,26,33)(H,28,34)/t15-,16+,18-,19-,20+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 115n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355652
PNG
(1-{2-[(2S,4R)-4-Fluoro-2-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ncccc12
Show InChI InChI=1S/C23H23FN6O3/c24-14-9-18(23(33)27-17-10-16(17)13-5-2-1-3-6-13)29(11-14)19(31)12-30-22-15(7-4-8-26-22)20(28-30)21(25)32/h1-8,14,16-18H,9-12H2,(H2,25,32)(H,27,33)/t14-,16+,17-,18+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 117n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355649
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccncc12
Show InChI InChI=1S/C24H24N6O3/c25-23(32)22-16-11-26-7-6-18(16)29(28-22)12-21(31)30-19-8-14(19)9-20(30)24(33)27-17-10-15(17)13-4-2-1-3-5-13/h1-7,11,14-15,17,19-20H,8-10,12H2,(H2,25,32)(H,27,33)/t14-,15+,17-,19-,20+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 118n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355662
PNG
(5-Chloro-1-{2-[(1R,3S,5R)-3- ((1R,2R)-2-fluoro-2-p...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@]2(F)c2ccccc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H23ClFN5O3/c26-15-6-7-17-16(10-15)22(23(28)34)30-31(17)12-21(33)32-18-8-13(18)9-19(32)24(35)29-20-11-25(20,27)14-4-2-1-3-5-14/h1-7,10,13,18-20H,8-9,11-12H2,(H2,28,34)(H,29,35)/t13-,18-,19+,20-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 119n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355664
PNG
((1R,3S,5S)-2-[2-(3-Acetyl-pyrazolo[3,4-c]pyridin-1...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H27N5O4/c1-15(33)24-17-7-8-27-12-21(17)30(29-24)13-23(34)31-20(10-26(14-32)11-22(26)31)25(35)28-19-9-18(19)16-5-3-2-4-6-16/h2-8,12,18-20,22,32H,9-11,13-14H2,1H3,(H,28,35)/t18-,19+,20-,22+,26-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 119n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355643
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ncccc12
Show InChI InChI=1S/C25H25N5O3/c1-14(31)23-17-8-5-9-26-24(17)29(28-23)13-22(32)30-20-10-16(20)11-21(30)25(33)27-19-12-18(19)15-6-3-2-4-7-15/h2-9,16,18-21H,10-13H2,1H3,(H,27,33)/t16-,18+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 123n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355705
PNG
(1-(2-{(1R,3S,5R)-3-[(1R,2S)-2-(2- Fluoro-phenyl)- ...)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3F)c2cn1)C(N)=O
Show InChI InChI=1S/C25H25FN6O3/c1-12-6-16-21(10-28-12)31(30-23(16)24(27)34)11-22(33)32-19-7-13(19)8-20(32)25(35)29-18-9-15(18)14-4-2-3-5-17(14)26/h2-6,10,13,15,18-20H,7-9,11H2,1H3,(H2,27,34)(H,29,35)/t13-,15+,18-,19-,20+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 125n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355697
PNG
((1R,2S,5S)-3-[2-(3-Acetyl-indazol- 1-yl)-acetyl]-3...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H]3C[C@H]3[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H26N4O3/c1-15(31)24-18-9-5-6-10-22(18)30(28-24)14-23(32)29-13-17-11-20(17)25(29)26(33)27-21-12-19(21)16-7-3-2-4-8-16/h2-10,17,19-21,25H,11-14H2,1H3,(H,27,33)/t17-,19+,20-,21-,25+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 131n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355675
PNG
(1-(2-{(2S,4R)-4-Fluoro-2-[(1R,2S)- 2-(2-fluoro-phe...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2F)c2cnccc12
Show InChI InChI=1S/C23H22F2N6O3/c24-12-7-18(23(34)28-17-8-15(17)13-3-1-2-4-16(13)25)30(10-12)20(32)11-31-19-9-27-6-5-14(19)21(29-31)22(26)33/h1-6,9,12,15,17-18H,7-8,10-11H2,(H2,26,33)(H,28,34)/t12-,15+,17-,18+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 142n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355638
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[4,3-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccncc12
Show InChI InChI=1S/C25H25N5O3/c1-14(31)24-18-12-26-8-7-20(18)29(28-24)13-23(32)30-21-9-16(21)10-22(30)25(33)27-19-11-17(19)15-5-3-2-4-6-15/h2-8,12,16-17,19,21-22H,9-11,13H2,1H3,(H,27,33)/t16-,17+,19-,21-,22+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 147n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355663
PNG
((1R,3S,5S)-2-[2-(3-Acetyl-pyrazolo[3,4-b]pyridin-1...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ncccc12
Show InChI InChI=1S/C26H27N5O4/c1-15(33)23-17-8-5-9-27-24(17)30(29-23)13-22(34)31-20(11-26(14-32)12-21(26)31)25(35)28-19-10-18(19)16-6-3-2-4-7-16/h2-9,18-21,32H,10-14H2,1H3,(H,28,35)/t18-,19+,20-,21+,26-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 172n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355648
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ncccc12
Show InChI InChI=1S/C24H24N6O3/c25-22(32)21-15-7-4-8-26-23(15)29(28-21)12-20(31)30-18-9-14(18)10-19(30)24(33)27-17-11-16(17)13-5-2-1-3-6-13/h1-8,14,16-19H,9-12H2,(H2,25,32)(H,27,33)/t14-,16+,17-,18-,19+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 172n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355678
PNG
(1-{2-[(1R,3S,5R)-3-((1R,2R)-2- Fluoro-2-phenyl- cy...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@]2(F)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C24H23FN6O3/c25-24(14-4-2-1-3-5-14)10-19(24)28-23(34)17-9-13-8-16(13)31(17)20(32)12-30-18-11-27-7-6-15(18)21(29-30)22(26)33/h1-7,11,13,16-17,19H,8-10,12H2,(H2,26,33)(H,28,34)/t13-,16-,17+,19-,24-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 214n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355689
PNG
((1R,3S,5R)-2-[2-(3-Acetyl-pyrazolo[3,4-b]pyridin-1...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2cccc(Cl)c2)c2ncccc12
Show InChI InChI=1S/C25H24ClN5O3/c1-13(32)23-17-6-3-7-27-24(17)30(29-23)12-22(33)31-20-9-15(20)10-21(31)25(34)28-19-11-18(19)14-4-2-5-16(26)8-14/h2-8,15,18-21H,9-12H2,1H3,(H,28,34)/t15-,18+,19-,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 225n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355646
PNG
((1R,3S,5R)-2-[2-(3-Acetyl-5,6- dimethoxy-indazol-1...)
Show SMILES COc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC)C(C)=O
Show InChI InChI=1S/C28H30N4O5/c1-15(33)27-19-12-24(36-2)25(37-3)13-22(19)31(30-27)14-26(34)32-21-9-17(21)10-23(32)28(35)29-20-11-18(20)16-7-5-4-6-8-16/h4-8,12-13,17-18,20-21,23H,9-11,14H2,1-3H3,(H,29,35)/t17-,18+,20-,21-,23+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 226n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355717
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-(3- phenyl-cyclohexylcarb...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H30N6O3/c28-26(35)25-20-9-10-29-14-23(20)32(31-25)15-24(34)33-21-12-18(21)13-22(33)27(36)30-19-8-4-7-17(11-19)16-5-2-1-3-6-16/h1-3,5-6,9-10,14,17-19,21-22H,4,7-8,11-13,15H2,(H2,28,35)(H,30,36)/t17?,18-,19?,21-,22+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 230n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355695
PNG
((2S,4R)-1-[2-(3-Acetyl-indazol-1- yl)-acetyl]-4-fl...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H25FN4O3/c1-15(31)24-18-9-5-6-10-21(18)30(28-24)14-23(32)29-13-17(26)11-22(29)25(33)27-20-12-19(20)16-7-3-2-4-8-16/h2-10,17,19-20,22H,11-14H2,1H3,(H,27,33)/t17-,19-,20+,22+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 294n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355707
PNG
(1-(2-{(2S,4R)-2-[(1R,2S)-2-(4- Chloro-phenyl)- cyc...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccc(Cl)cc2)c2cnccc12
Show InChI InChI=1S/C23H22ClFN6O3/c24-13-3-1-12(2-4-13)16-8-17(16)28-23(34)18-7-14(25)10-30(18)20(32)11-31-19-9-27-6-5-15(19)21(29-31)22(26)33/h1-6,9,14,16-18H,7-8,10-11H2,(H2,26,33)(H,28,34)/t14-,16+,17-,18+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 309n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355667
PNG
(US9815819, 32)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2cccc(c2)C(F)F)c2cnccc12
Show InChI InChI=1S/C26H25F2N5O3/c1-13(34)24-17-5-6-29-11-22(17)32(31-24)12-23(35)33-20-8-16(20)9-21(33)26(36)30-19-10-18(19)14-3-2-4-15(7-14)25(27)28/h2-7,11,16,18-21,25H,8-10,12H2,1H3,(H,30,36)/t16-,18?,19?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 326n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355685
PNG
(1-(2-{(1R,3S,5R)-3-[2-Fluoro-2-(2- fluoro-phenyl)-...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2(F)c2ccccc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-16-7-3-2-6-15(16)25(27)11-20(25)29-24(35)19-10-13-9-18(13)32(19)21(33)12-31-17-8-4-1-5-14(17)22(30-31)23(28)34/h1-8,13,18-20H,9-12H2,(H2,28,34)(H,29,35)/t13-,18-,19+,20?,25?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 367n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355655
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2cc3OCCOc3cc12
Show InChI InChI=1S/C27H27N5O5/c28-26(34)25-17-11-22-23(37-7-6-36-22)12-20(17)31(30-25)13-24(33)32-19-8-15(19)9-21(32)27(35)29-18-10-16(18)14-4-2-1-3-5-14/h1-5,11-12,15-16,18-19,21H,6-10,13H2,(H2,28,34)(H,29,35)/t15-,16+,18-,19-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 368n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355636
PNG
((1R,3S,5R)-2-[2-(3-Acetyl-indazol-1- yl)-acetyl]-2...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H26N4O3/c1-15(31)25-18-9-5-6-10-21(18)29(28-25)14-24(32)30-22-11-17(22)12-23(30)26(33)27-20-13-19(20)16-7-3-2-4-8-16/h2-10,17,19-20,22-23H,11-14H2,1H3,(H,27,33)/t17-,19+,20-,22-,23+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 386n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355671
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC(C2)c2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H26FN5O3/c1-14(33)24-19-6-4-8-28-25(19)31(30-24)13-23(34)32-21-11-16(21)12-22(32)26(35)29-17-9-15(10-17)18-5-2-3-7-20(18)27/h2-8,15-17,21-22H,9-13H2,1H3,(H,29,35)/t15?,16-,17?,21-,22+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 466n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355713
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-(3- phenyl-cyclohexylcarb...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C28H31N5O3/c29-27(35)26-21-11-4-5-12-22(21)32(31-26)16-25(34)33-23-14-19(23)15-24(33)28(36)30-20-10-6-9-18(13-20)17-7-2-1-3-8-17/h1-5,7-8,11-12,18-20,23-24H,6,9-10,13-16H2,(H2,29,35)(H,30,36)/t18?,19-,20?,23-,24+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 475n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355668
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2cccc(c2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C26H24F3N5O3/c1-13(35)24-17-5-6-30-11-22(17)33(32-24)12-23(36)34-20-8-15(20)9-21(34)25(37)31-19-10-18(19)14-3-2-4-16(7-14)26(27,28)29/h2-7,11,15,18-21H,8-10,12H2,1H3,(H,31,37)/t15-,18?,19?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355673
PNG
(1-{2-[(1R,3S,5R)-3-((1S,2S)-2-fluoro-2-phenyl-cycl...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@]2(F)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H24FN5O3/c26-25(15-6-2-1-3-7-15)12-20(25)28-24(34)19-11-14-10-18(14)31(19)21(32)13-30-17-9-5-4-8-16(17)22(29-30)23(27)33/h1-9,14,18-20H,10-13H2,(H2,27,33)(H,28,34)/t14-,18-,19+,20+,25+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 635n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355709
PNG
(1-(2-{(1R,3S,5R)-3-[2-(2,4- Difluoro-phenyl)- cycl...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2ccc(F)cc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-13-5-6-14(17(27)9-13)16-10-18(16)29-25(35)21-8-12-7-20(12)32(21)22(33)11-31-19-4-2-1-3-15(19)23(30-31)24(28)34/h1-6,9,12,16,18,20-21H,7-8,10-11H2,(H2,28,34)(H,29,35)/t12-,16?,18?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 640n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355720
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((R)-3- phenyl-cyclopenty...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC[C@H](C2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H28N6O3/c27-25(34)24-19-8-9-28-13-22(19)31(30-24)14-23(33)32-20-11-17(20)12-21(32)26(35)29-18-7-6-16(10-18)15-4-2-1-3-5-15/h1-5,8-9,13,16-18,20-21H,6-7,10-12,14H2,(H2,27,34)(H,29,35)/t16-,17-,18?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 648n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355639
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C25H25N5O3/c1-14(31)24-17-7-8-26-12-22(17)29(28-24)13-23(32)30-20-9-16(20)10-21(30)25(33)27-19-11-18(19)15-5-3-2-4-6-15/h2-8,12,16,18-21H,9-11,13H2,1H3,(H,27,33)/t16-,18-,19+,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 702n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355704
PNG
(1-(2-{(1R,3S,5R)-3-[(1S,2R)-2-(2- Chloro-phenyl)- ...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2Cl)c2ccccc12
Show InChI InChI=1S/C25H24ClN5O3/c26-17-7-3-1-5-14(17)16-11-18(16)28-25(34)21-10-13-9-20(13)31(21)22(32)12-30-19-8-4-2-6-15(19)23(29-30)24(27)33/h1-8,13,16,18,20-21H,9-12H2,(H2,27,33)(H,28,34)/t13-,16-,18+,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 764n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355696
PNG
((1R,2S,5S)-3-[2-(3-Acetyl-indazol- 1-yl)-acetyl]-3...)
Show SMILES CC(=O)c1nn(CC(=O)N2C[C@H]3C[C@H]3[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H26N4O3/c1-15(31)24-18-9-5-6-10-22(18)30(28-24)14-23(32)29-13-17-11-20(17)25(29)26(33)27-21-12-19(21)16-7-3-2-4-8-16/h2-10,17,19-21,25H,11-14H2,1H3,(H,27,33)/t17-,19-,20-,21+,25+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 776n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355641
PNG
(5,6-Dimethoxy-1-{2-oxo-2- [(1R,3S,5R)-3-((1R,2S)-2...)
Show SMILES COc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC)C(N)=O
Show InChI InChI=1S/C27H29N5O5/c1-36-22-11-17-20(12-23(22)37-2)31(30-25(17)26(28)34)13-24(33)32-19-8-15(19)9-21(32)27(35)29-18-10-16(18)14-6-4-3-5-7-14/h3-7,11-12,15-16,18-19,21H,8-10,13H2,1-2H3,(H2,28,34)(H,29,35)/t15-,16+,18-,19-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 789n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355699
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2F)c2ncccc12
Show InChI InChI=1S/C25H24FN5O3/c1-13(32)23-16-6-4-8-27-24(16)30(29-23)12-22(33)31-20-9-14(20)10-21(31)25(34)28-19-11-17(19)15-5-2-3-7-18(15)26/h2-8,14,17,19-21H,9-12H2,1H3,(H,28,34)/t14-,17-,19+,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 791n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355657
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@]2(C)C[C@H]2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H27N5O3/c1-15(32)24-18-8-9-27-13-22(18)30(29-24)14-23(33)31-20-10-17(20)11-21(31)25(34)28-26(2)12-19(26)16-6-4-3-5-7-16/h3-9,13,17,19-21H,10-12,14H2,1-2H3,(H,28,34)/t17-,19+,20-,21+,26-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 870n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355670
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC(C2)c2ccccc2)c2ncccc12
Show InChI InChI=1S/C26H27N5O3/c1-15(32)24-20-8-5-9-27-25(20)30(29-24)14-23(33)31-21-12-18(21)13-22(31)26(34)28-19-10-17(11-19)16-6-3-2-4-7-16/h2-9,17-19,21-22H,10-14H2,1H3,(H,28,34)/t17?,18-,19?,21-,22+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 902n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355682
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@]2(F)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C25H24FN5O3/c1-14(32)23-17-7-8-27-12-20(17)30(29-23)13-22(33)31-18-9-15(18)10-19(31)24(34)28-21-11-25(21,26)16-5-3-2-4-6-16/h2-8,12,15,18-19,21H,9-11,13H2,1H3,(H,28,34)/t15-,18-,19+,21+,25+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 991n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355685
PNG
(1-(2-{(1R,3S,5R)-3-[2-Fluoro-2-(2- fluoro-phenyl)-...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2(F)c2ccccc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-16-7-3-2-6-15(16)25(27)11-20(25)29-24(35)19-10-13-9-18(13)32(19)21(33)12-31-17-8-4-1-5-14(17)22(30-31)23(28)34/h1-8,13,18-20H,9-12H2,(H2,28,34)(H,29,35)/t13-,18-,19+,20?,25?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 992n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355672
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCC(CC2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H31N5O3/c1-17(34)27-22-11-12-29-15-25(22)32(31-27)16-26(35)33-23-13-20(23)14-24(33)28(36)30-21-9-7-19(8-10-21)18-5-3-2-4-6-18/h2-6,11-12,15,19-21,23-24H,7-10,13-14,16H2,1H3,(H,30,36)/t19?,20-,21?,23-,24+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.06E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355684
PNG
(1-{2-[(1R,3S,5R)-3-((1S,2S)-2- Fluoro-2-phenyl- cy...)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@H]3C[C@]3(F)c3ccccc3)c2cn1)C(N)=O
Show InChI InChI=1S/C25H25FN6O3/c1-13-7-16-19(11-28-13)31(30-22(16)23(27)34)12-21(33)32-17-8-14(17)9-18(32)24(35)29-20-10-25(20,26)15-5-3-2-4-6-15/h2-7,11,14,17-18,20H,8-10,12H2,1H3,(H2,27,34)(H,29,35)/t14-,17-,18+,20+,25+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.19E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355676
PNG
(1-(2-{(2S,4R)-4-Fluoro-2-[(1S,2R)- 2-(2-fluoro-phe...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2F)c2cnccc12
Show InChI InChI=1S/C23H22F2N6O3/c24-12-7-18(23(34)28-17-8-15(17)13-3-1-2-4-16(13)25)30(10-12)20(32)11-31-19-9-27-6-5-14(19)21(29-31)22(26)33/h1-6,9,12,15,17-18H,7-8,10-11H2,(H2,26,33)(H,28,34)/t12-,15-,17+,18+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.19E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355720
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((R)-3- phenyl-cyclopenty...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC[C@H](C2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H28N6O3/c27-25(34)24-19-8-9-28-13-22(19)31(30-24)14-23(33)32-20-11-17(20)12-21(32)26(35)29-18-7-6-16(10-18)15-4-2-1-3-5-15/h1-5,8-9,13,16-18,20-21H,6-7,10-12,14H2,(H2,27,34)(H,29,35)/t16-,17-,18?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.23E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355651
PNG
(1-{2-[(2S,4R)-4-Fluoro-2-((1R,2S)- 2-phenyl-cyclop...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ccncc12
Show InChI InChI=1S/C23H23FN6O3/c24-14-8-19(23(33)27-17-9-15(17)13-4-2-1-3-5-13)29(11-14)20(31)12-30-18-6-7-26-10-16(18)21(28-30)22(25)32/h1-7,10,14-15,17,19H,8-9,11-12H2,(H2,25,32)(H,27,33)/t14-,15+,17-,19+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.24E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355718
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((S)-3- phenyl-cyclopenty...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC[C@@H](C2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H28N6O3/c27-25(34)24-19-8-9-28-13-22(19)31(30-24)14-23(33)32-20-11-17(20)12-21(32)26(35)29-18-7-6-16(10-18)15-4-2-1-3-5-15/h1-5,8-9,13,16-18,20-21H,6-7,10-12,14H2,(H2,27,34)(H,29,35)/t16-,17+,18?,20+,21-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.29E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355656
PNG
(1-(2-{(1R,3S,5R)-3-[(1S,2R)-2-(2- Chloro-phenyl)- ...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2Cl)c2cnccc12
Show InChI InChI=1S/C24H23ClN6O3/c25-16-4-2-1-3-13(16)15-9-17(15)28-24(34)19-8-12-7-18(12)31(19)21(32)11-30-20-10-27-6-5-14(20)22(29-30)23(26)33/h1-6,10,12,15,17-19H,7-9,11H2,(H2,26,33)(H,28,34)/t12-,15-,17+,18-,19+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355718
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-((S)-3- phenyl-cyclopenty...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC[C@@H](C2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H28N6O3/c27-25(34)24-19-8-9-28-13-22(19)31(30-24)14-23(33)32-20-11-17(20)12-21(32)26(35)29-18-7-6-16(10-18)15-4-2-1-3-5-15/h1-5,8-9,13,16-18,20-21H,6-7,10-12,14H2,(H2,27,34)(H,29,35)/t16-,17+,18?,20+,21-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.45E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355690
PNG
((1R,3S,5R)-2-[2-(3-acetyl-pyrazolo[3,4-b]pyridin-1...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@@H]2c2cccc(Cl)c2)c2ncccc12
Show InChI InChI=1S/C25H24ClN5O3/c1-13(32)23-17-6-3-7-27-24(17)30(29-23)12-22(33)31-20-9-15(20)10-21(31)25(34)28-19-11-18(19)14-4-2-5-16(26)8-14/h2-8,15,18-21H,9-12H2,1H3,(H,28,34)/t15-,18-,19+,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.58E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355692
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@@H]2c2cccc(Cl)c2F)c2ncccc12
Show InChI InChI=1S/C25H23ClFN5O3/c1-12(33)23-15-5-3-7-28-24(15)31(30-23)11-21(34)32-19-8-13(19)9-20(32)25(35)29-18-10-16(18)14-4-2-6-17(26)22(14)27/h2-7,13,16,18-20H,8-11H2,1H3,(H,29,35)/t13-,16-,18+,19-,20+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.61E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355713
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-(3- phenyl-cyclohexylcarb...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C28H31N5O3/c29-27(35)26-21-11-4-5-12-22(21)32(31-26)16-25(34)33-23-14-19(23)15-24(33)28(36)30-20-10-6-9-18(13-20)17-7-2-1-3-8-17/h1-5,7-8,11-12,18-20,23-24H,6,9-10,13-16H2,(H2,29,35)(H,30,36)/t18?,19-,20?,23-,24+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355677
PNG
(1-{2-[(1R,3S,5R)-3-((1S,2S)-2- Fluoro-2-phenyl- cy...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@]2(F)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C24H23FN6O3/c25-24(14-4-2-1-3-5-14)10-19(24)28-23(34)17-9-13-8-16(13)31(17)20(32)12-30-18-11-27-7-6-15(18)21(29-30)22(26)33/h1-7,11,13,16-17,19H,8-10,12H2,(H2,26,33)(H,28,34)/t13-,16-,17+,19+,24+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.65E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355709
PNG
(1-(2-{(1R,3S,5R)-3-[2-(2,4- Difluoro-phenyl)- cycl...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2ccc(F)cc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-13-5-6-14(17(27)9-13)16-10-18(16)29-25(35)21-8-12-7-20(12)32(21)22(33)11-31-19-4-2-1-3-15(19)23(30-31)24(28)34/h1-6,9,12,16,18,20-21H,7-8,10-11H2,(H2,28,34)(H,29,35)/t12-,16?,18?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.76E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355685
PNG
(1-(2-{(1R,3S,5R)-3-[2-Fluoro-2-(2- fluoro-phenyl)-...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2(F)c2ccccc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-16-7-3-2-6-15(16)25(27)11-20(25)29-24(35)19-10-13-9-18(13)32(19)21(33)12-31-17-8-4-1-5-14(17)22(30-31)23(28)34/h1-8,13,18-20H,9-12H2,(H2,28,34)(H,29,35)/t13-,18-,19+,20?,25?/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.88E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355642
PNG
(5,6-Dimethoxy-1-{2-oxo-2- [(1R,3S,5R)-3-((1S,2R)-2...)
Show SMILES COc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@H]3C[C@@H]3c3ccccc3)c2cc1OC)C(N)=O
Show InChI InChI=1S/C27H29N5O5/c1-36-22-11-17-20(12-23(22)37-2)31(30-25(17)26(28)34)13-24(33)32-19-8-15(19)9-21(32)27(35)29-18-10-16(18)14-6-4-3-5-7-14/h3-7,11-12,15-16,18-19,21H,8-10,13H2,1-2H3,(H2,28,34)(H,29,35)/t15-,16-,18+,19-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.50E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355713
PNG
(1-{2-Oxo-2-[(1R,3S,5R)-3-(3- phenyl-cyclohexylcarb...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C28H31N5O3/c29-27(35)26-21-11-4-5-12-22(21)32(31-26)16-25(34)33-23-14-19(23)15-24(33)28(36)30-20-10-6-9-18(13-20)17-7-2-1-3-8-17/h1-5,7-8,11-12,18-20,23-24H,6,9-10,13-16H2,(H2,29,35)(H,30,36)/t18?,19-,20?,23-,24+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.65E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355709
PNG
(1-(2-{(1R,3S,5R)-3-[2-(2,4- Difluoro-phenyl)- cycl...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2ccc(F)cc2F)c2ccccc12
Show InChI InChI=1S/C25H23F2N5O3/c26-13-5-6-14(17(27)9-13)16-10-18(16)29-25(35)21-8-12-7-20(12)32(21)22(33)11-31-19-4-2-1-3-15(19)23(30-31)24(28)34/h1-6,9,12,16,18,20-21H,7-8,10-11H2,(H2,28,34)(H,29,35)/t12-,16?,18?,20-,21+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.76E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355680
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-b]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@]2(F)c2ccccc2)c2ncccc12
Show InChI InChI=1S/C25H24FN5O3/c1-14(32)22-17-8-5-9-27-23(17)30(29-22)13-21(33)31-18-10-15(18)11-19(31)24(34)28-20-12-25(20,26)16-6-3-2-4-7-16/h2-9,15,18-20H,10-13H2,1H3,(H,28,34)/t15-,18-,19+,20+,25+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.04E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355658
PNG
((1R,3S,5R)-2-[2-(3-Acetyl- pyrazolo[3,4-c]pyridin-...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@]2(C)C[C@@H]2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H27N5O3/c1-15(32)24-18-8-9-27-13-22(18)30(29-24)14-23(33)31-20-10-17(20)11-21(31)25(34)28-26(2)12-19(26)16-6-4-3-5-7-16/h3-9,13,17,19-21H,10-12,14H2,1-2H3,(H,28,34)/t17-,19-,20-,21+,26+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.32E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))		BDBM355659
PNG
(1-{2-[(1R,3S,5R)-3-((1S,2R)-1- Methyl-2-phenyl-cyc...)
Show SMILES C[C@@]1(C[C@@H]1c1ccccc1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C26H27N5O3/c1-26(13-18(26)15-7-3-2-4-8-15)28-25(34)21-12-16-11-20(16)31(21)22(32)14-30-19-10-6-5-9-17(19)23(29-30)24(27)33/h2-10,16,18,20-21H,11-14H2,1H3,(H2,27,33)(H,28,34)/t16-,18-,20-,21+,26+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.76E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9815819 (2017)


BindingDB Entry DOI: 10.7270/Q2QF8W1V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%