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Patent code US9815820

Compile Data Set for Download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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10n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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20n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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20n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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30n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322155
PNG
(US10183931, SLx-2119 | US9815820, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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40n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM355727
PNG
(US9815820, Y-27263)
Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-
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40n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM355727
PNG
(US9815820, Y-27263)
Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-
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60n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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70n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322157
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H22N6O4S/c30-22(29-8-10-34(31,32)11-9-29)15-33-19-3-1-2-16(13-19)23-24-7-6-21(27-23)26-18-4-5-20-17(12-18)14-25-28-20/h1-7,12-14H,8-11,15H2,(H,25,28)(H,24,26,27)
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170n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322155
PNG
(US10183931, SLx-2119 | US9815820, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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870n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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2.01E+3n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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n/an/a 330n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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n/an/a 470n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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n/an/a 540n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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n/an/a 720n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322155
PNG
(US10183931, SLx-2119 | US9815820, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM355727
PNG
(US9815820, Y-27263)
Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-
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US Patent
n/an/a 1.13E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM355727
PNG
(US9815820, Y-27263)
Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-
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US Patent
n/an/a 1.63E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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n/an/a 1.77E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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n/an/a 1.96E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322157
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H22N6O4S/c30-22(29-8-10-34(31,32)11-9-29)15-33-19-3-1-2-16(13-19)23-24-7-6-21(27-23)26-18-4-5-20-17(12-18)14-25-28-20/h1-7,12-14H,8-11,15H2,(H,25,28)(H,24,26,27)
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US Patent
n/an/a 4.25E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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n/an/a 4.64E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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US Patent
n/an/a 6.69E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322155
PNG
(US10183931, SLx-2119 | US9815820, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a 1.31E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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US Patent
n/an/a 2.25E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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n/an/a 5.35E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...


US Patent US9815820 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%