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Patent code US9815832

Compile Data Set for Download or QSAR
Found 184 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355759
PNG
(3-(4-Chloro-3,5-difluorophenyl)-N-cyclopropyl-3H-i...)
Show SMILES Fc1cc(cc(F)c1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-9(7-11(13)19)23-14-12(2-1-5-20-14)22-15(23)16(24)21-8-3-4-8/h1-2,5-8H,3-4H2,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.65n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355753
PNG
(N-Cyclopropyl-3-(3,4,5-trifluorophenyl)-3H-imidazo...)
Show SMILES Fc1cc(cc(F)c1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H11F3N4O/c17-10-6-9(7-11(18)13(10)19)23-14-12(2-1-5-20-14)22-15(23)16(24)21-8-3-4-8/h1-2,5-8H,3-4H2,(H,21,24)
PDB

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GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 5.77n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355750
PNG
(N-Cyclopropyl-3-(3,4-dichlorophenyl)-3H-imidazo[4,...)
Show SMILES Clc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12Cl2N4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355743
PNG
(3-(4-Cyano-3,5-difluorophenyl)-N-cyclopropyl-3H-im...)
Show SMILES Fc1cc(cc(F)c1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H11F2N5O/c18-12-6-10(7-13(19)11(12)8-20)24-15-14(2-1-5-21-15)23-16(24)17(25)22-9-3-4-9/h1-2,5-7,9H,3-4H2,(H,22,25)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355732
PNG
(Azetidin-1-yl[3-(4-chloro-3,5-difluorophenyl)-3H-i...)
Show SMILES Fc1cc(cc(F)c1Cl)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)7-9(8-11(13)19)23-14-12(3-1-4-20-14)21-15(23)16(24)22-5-2-6-22/h1,3-4,7-8H,2,5-6H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355733
PNG
(Azetidin-1-yl[3-(4-chloro-3-fluorophenyl)-3H-imida...)
Show SMILES Fc1cc(ccc1Cl)-n1c(nc2cccnc12)C(Cl)(Cl)Cl
Show InChI InChI=1S/C13H6Cl4FN3/c14-8-4-3-7(6-9(8)18)21-11-10(2-1-5-19-11)20-12(21)13(15,16)17/h1-6H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355755
PNG
(3-(3-Chloro-4-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-8-10(5-6-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355756
PNG
(3-(3-Chloro-4-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-7-12(9-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355731
PNG
(4-[2-(Azetidin-1-ylcarbonyl)-3H-imidazo[4,5-b]pyri...)
Show SMILES Fc1cc(ccc1C#N)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C17H12FN5O/c18-13-9-12(5-4-11(13)10-19)23-15-14(3-1-6-20-15)21-16(23)17(24)22-7-2-8-22/h1,3-6,9H,2,7-8H2
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355726
PNG
(3-(4-Chloro-3-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1cc(ccc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355723
PNG
(N-Cyclopropyl-3-(3-fluoro-4-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-4-7-12(9-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355785
PNG
(N-Cyclopropyl-3-(3,4-difluorophenyl)-3H-imidazo[4,...)
Show SMILES Fc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F2N4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 34.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355729
PNG
(3-(4-Chloro-3-fluorophenyl)-N-propyl-3H-imidazo[4,...)
Show SMILES CCCNC(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H14ClFN4O/c1-2-7-20-16(23)15-21-13-4-3-8-19-14(13)22(15)10-5-6-11(17)12(18)9-10/h3-6,8-9H,2,7H2,1H3,(H,20,23)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 38.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355730
PNG
(3-(4-Cyano-3-fluorophenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Fc1cc(ccc1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H12FN5O/c18-13-8-12(6-3-10(13)9-19)23-15-14(2-1-7-20-15)22-16(23)17(24)21-11-4-5-11/h1-3,6-8,11H,4-5H2,(H,21,24)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 40.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355795
PNG
(N-Cyclopropyl-3-[3-(methylsulfanyl)phenyl]-3H-imid...)
Show SMILES CSc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4OS/c1-23-13-5-2-4-12(10-13)21-15-14(6-3-9-18-15)20-16(21)17(22)19-11-7-8-11/h2-6,9-11H,7-8H2,1H3,(H,19,22)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 40.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355744
PNG
(US9815832, 21 | [3-(4-Chloro-3-fluorophenyl)-3H-im...)
Show SMILES FC1CN(C1)C(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H11ClF2N4O/c17-11-4-3-10(6-12(11)19)23-14-13(2-1-5-20-14)21-15(23)16(24)22-7-9(18)8-22/h1-6,9H,7-8H2
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 42.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355741
PNG
(Azetidin-1-yl[3-(3-fluoro-4-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C17H15FN4O/c1-11-5-6-12(10-13(11)18)22-15-14(4-2-7-19-15)20-16(22)17(23)21-8-3-9-21/h2,4-7,10H,3,8-9H2,1H3
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355728
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1ccc(NC(=O)c2nc3cccnc3n2-c2ccc(Cl)c(F)c2)n1
Show InChI InChI=1S/C17H12ClFN6O/c1-24-8-6-14(23-24)22-17(26)16-21-13-3-2-7-20-15(13)25(16)10-4-5-11(18)12(19)9-10/h2-9H,1H3,(H,22,23,26)
PDB

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PC sid
UniChem
US Patent
n/an/a 54.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355797
PNG
(3-(4-Chloro-3-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1cc(ccc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-9-12(6-7-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-4-5-11/h2-3,6-9,11H,4-5H2,1H3,(H,20,23)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 58.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355786
PNG
(N-Cyclopropyl-3-(3,5-dichlorophenyl)-3H-imidazo[4,...)
Show SMILES Clc1cc(Cl)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12Cl2N4O/c17-9-6-10(18)8-12(7-9)22-14-13(2-1-5-19-14)21-15(22)16(23)20-11-3-4-11/h1-2,5-8,11H,3-4H2,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 68n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355792
PNG
(3-(3-Chlorophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]...)
Show SMILES Clc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13ClN4O/c17-10-3-1-4-12(9-10)21-14-13(5-2-8-18-14)20-15(21)16(22)19-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,19,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 70.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355754
PNG
(3-(3-Cyano-4-fluorophenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Fc1ccc(cc1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H12FN5O/c18-13-6-5-12(8-10(13)9-19)23-15-14(2-1-7-20-15)22-16(23)17(24)21-11-3-4-11/h1-2,5-8,11H,3-4H2,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 87.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355771
PNG
(N-Cyclopropyl-3-(3,5-difluorophenyl)-3H-imidazo[4,...)
Show SMILES Fc1cc(F)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F2N4O/c17-9-6-10(18)8-12(7-9)22-14-13(2-1-5-19-14)21-15(22)16(23)20-11-3-4-11/h1-2,5-8,11H,3-4H2,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355735
PNG
(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-3H-i...)
Show SMILES Fc1cc(c(F)cc1Cl)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-9-7-11(19)13(8-10(9)18)23-14-12(3-1-4-20-14)21-15(23)16(24)22-5-2-6-22/h1,3-4,7-8H,2,5-6H2
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355764
PNG
(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl-3H-i...)
Show SMILES Fc1cc(c(F)cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-9-6-11(19)13(7-10(9)18)23-14-12(2-1-5-20-14)22-15(23)16(24)21-8-3-4-8/h1-2,5-8H,3-4H2,(H,21,24)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355802
PNG
(3-(5-Chloro-2-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1ccc(Cl)cc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-9-3-6-11(18)13(8-9)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355751
PNG
(N-Cyclopropyl-3-(4-fluoro-3-methylphenyl)-3H-imida...)
Show SMILES Cc1cc(ccc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-9-12(6-7-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-4-5-11/h2-3,6-9,11H,4-5H2,1H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355725
PNG
(3-(4-Chlorophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]...)
Show SMILES Clc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13ClN4O/c17-10-3-7-12(8-4-10)21-14-13(2-1-9-18-14)20-15(21)16(22)19-11-5-6-11/h1-4,7-9,11H,5-6H2,(H,19,22)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355794
PNG
(3-(1,3-Benzothiazol-6-yl)-N-cyclopropyl-3H-imidazo...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H13N5OS/c23-17(20-10-3-4-10)16-21-13-2-1-7-18-15(13)22(16)11-5-6-12-14(8-11)24-9-19-12/h1-2,5-10H,3-4H2,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355779
PNG
(3-(3-Cyano-4-methylphenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Cc1ccc(cc1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H15N5O/c1-11-4-7-14(9-12(11)10-19)23-16-15(3-2-8-20-16)22-17(23)18(24)21-13-5-6-13/h2-4,7-9,13H,5-6H2,1H3,(H,21,24)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355788
PNG
(N-Cyclopropyl-3-(3-fluorophenyl)-3H-imidazo[4,5-b]...)
Show SMILES Fc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13FN4O/c17-10-3-1-4-12(9-10)21-14-13(5-2-8-18-14)20-15(21)16(22)19-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,19,22)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355739
PNG
(Azetidin-1-yl[3-(4-chlorophenyl)-3H-imidazo[4,5-b]...)
Show SMILES Clc1ccc(cc1)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H13ClN4O/c17-11-4-6-12(7-5-11)21-14-13(3-1-8-18-14)19-15(21)16(22)20-9-2-10-20/h1,3-8H,2,9-10H2
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355768
PNG
(N-Cyclopropyl-3-(3-fluoro-4-methoxyphenyl)-3H-imid...)
Show SMILES COc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O2/c1-24-14-7-6-11(9-12(14)18)22-15-13(3-2-8-19-15)21-16(22)17(23)20-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355787
PNG
(N-Cyclopropyl-3-(2,3-dihydro-1H-inden-5-yl)-3H-imi...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2CCCc2c1
Show InChI InChI=1S/C19H18N4O/c24-19(21-14-7-8-14)18-22-16-5-2-10-20-17(16)23(18)15-9-6-12-3-1-4-13(12)11-15/h2,5-6,9-11,14H,1,3-4,7-8H2,(H,21,24)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355774
PNG
(N-Cyclopropyl-3-(4-methoxy-3-methylphenyl)-3H-imid...)
Show SMILES COc1ccc(cc1C)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O2/c1-11-10-13(7-8-15(11)24-2)22-16-14(4-3-9-19-16)21-17(22)18(23)20-12-5-6-12/h3-4,7-10,12H,5-6H2,1-2H3,(H,20,23)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355747
PNG
(3-(4-Chlorophenyl)-N-(1-methyl-1H-pyrazol-3-yl)-3H...)
Show SMILES Cn1ccc(NC(=O)c2nc3cccnc3n2-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C17H13ClN6O/c1-23-10-8-14(22-23)21-17(25)16-20-13-3-2-9-19-15(13)24(16)12-6-4-11(18)5-7-12/h2-10H,1H3,(H,21,22,25)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355791
PNG
(N-Cyclopropyl-3-(4-fluorophenyl)-3H-imidazo[4,5-b]...)
Show SMILES Fc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13FN4O/c17-10-3-7-12(8-4-10)21-14-13(2-1-9-18-14)20-15(21)16(22)19-11-5-6-11/h1-4,7-9,11H,5-6H2,(H,19,22)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355752
PNG
(N-Cyclopropyl-3-(4-methylphenyl)-3H-imidazo[4,5-b]...)
Show SMILES Cc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O/c1-11-4-8-13(9-5-11)21-15-14(3-2-10-18-15)20-16(21)17(22)19-12-6-7-12/h2-5,8-10,12H,6-7H2,1H3,(H,19,22)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355759
PNG
(3-(4-Chloro-3,5-difluorophenyl)-N-cyclopropyl-3H-i...)
Show SMILES Fc1cc(cc(F)c1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-9(7-11(13)19)23-14-12(2-1-5-20-14)22-15(23)16(24)21-8-3-4-8/h1-2,5-8H,3-4H2,(H,21,24)
PDB

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355743
PNG
(3-(4-Cyano-3,5-difluorophenyl)-N-cyclopropyl-3H-im...)
Show SMILES Fc1cc(cc(F)c1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H11F2N5O/c18-12-6-10(7-13(19)11(12)8-20)24-15-14(2-1-5-21-15)23-16(24)17(25)22-9-3-4-9/h1-2,5-7,9H,3-4H2,(H,22,25)
PDB

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355775
PNG
(N-Cyclopropyl-3-(3,4-dimethylphenyl)-3H-imidazo[4,...)
Show SMILES Cc1ccc(cc1C)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O/c1-11-5-8-14(10-12(11)2)22-16-15(4-3-9-19-16)21-17(22)18(23)20-13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355745
PNG
(Azetidin-1-yl[3-(4-chloro-2-fluorophenyl)-3H-imida...)
Show SMILES Fc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H12ClFN4O/c17-10-4-5-13(11(18)9-10)22-14-12(3-1-6-19-14)20-15(22)16(23)21-7-2-8-21/h1,3-6,9H,2,7-8H2
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355765
PNG
(3-(4-Cyanophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]p...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc(cc1)C#N
Show InChI InChI=1S/C17H13N5O/c18-10-11-3-7-13(8-4-11)22-15-14(2-1-9-19-15)21-16(22)17(23)20-12-5-6-12/h1-4,7-9,12H,5-6H2,(H,20,23)
PDB

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355742
PNG
((3-Fluoroazetidin-1-yl)[3-(3-fluoro-4-methylphenyl...)
Show SMILES Cc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)N1CC(F)C1
Show InChI InChI=1S/C17H14F2N4O/c1-10-4-5-12(7-13(10)19)23-15-14(3-2-6-20-15)21-16(23)17(24)22-8-11(18)9-22/h2-7,11H,8-9H2,1H3
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355776
PNG
(3-(3-Cyanophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]p...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1cccc(c1)C#N
Show InChI InChI=1S/C17H13N5O/c18-10-11-3-1-4-13(9-11)22-15-14(5-2-8-19-15)21-16(22)17(23)20-12-6-7-12/h1-5,8-9,12H,6-7H2,(H,20,23)
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n/an/a 287n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355778
PNG
(N-Cyclopropyl-3-(4-fluoro-3-methoxyphenyl)-3H-imid...)
Show SMILES COc1cc(ccc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O2/c1-24-14-9-11(6-7-12(14)18)22-15-13(3-2-8-19-15)21-16(22)17(23)20-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,20,23)
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Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355744
PNG
(US9815832, 21 | [3-(4-Chloro-3-fluorophenyl)-3H-im...)
Show SMILES FC1CN(C1)C(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H11ClF2N4O/c17-11-4-3-10(6-12(11)19)23-14-13(2-1-5-20-14)21-15(23)16(24)22-7-9(18)8-22/h1-6,9H,7-8H2
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355749
PNG
(3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-9-11(18)4-7-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-5-6-12/h2-4,7-9,12H,5-6H2,1H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355769
PNG
(N-Cyclopropyl-3-(3-methoxyphenyl)-3H-imidazo[4,5-b...)
Show SMILES COc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O2/c1-23-13-5-2-4-12(10-13)21-15-14(6-3-9-18-15)20-16(21)17(22)19-11-7-8-11/h2-6,9-11H,7-8H2,1H3,(H,19,22)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355777
PNG
(3-(5-Chloro-2-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(Cl)cc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-5-11(18)9-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)
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Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355753
PNG
(N-Cyclopropyl-3-(3,4,5-trifluorophenyl)-3H-imidazo...)
Show SMILES Fc1cc(cc(F)c1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H11F3N4O/c17-10-6-9(7-11(18)13(10)19)23-14-12(2-1-5-20-14)22-15(23)16(24)21-8-3-4-8/h1-2,5-8H,3-4H2,(H,21,24)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355773
PNG
(N-Cyclopropyl-3-(3-methoxy-4-methylphenyl)-3H-imid...)
Show SMILES COc1cc(ccc1C)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O2/c1-11-5-8-13(10-15(11)24-2)22-16-14(4-3-9-19-16)21-17(22)18(23)20-12-6-7-12/h3-5,8-10,12H,6-7H2,1-2H3,(H,20,23)
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US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355762
PNG
(3-(6-Cyanopyridin-3-yl)-N-cyclopropyl-3H-imidazo[4...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc(nc1)C#N
Show InChI InChI=1S/C16H12N6O/c17-8-11-5-6-12(9-19-11)22-14-13(2-1-7-18-14)21-15(22)16(23)20-10-3-4-10/h1-2,5-7,9-10H,3-4H2,(H,20,23)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355799
PNG
(N-Cyclopropyl-3-(3,5-dimethylphenyl)-3H-imidazo[4,...)
Show SMILES Cc1cc(C)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O/c1-11-8-12(2)10-14(9-11)22-16-15(4-3-7-19-16)21-17(22)18(23)20-13-5-6-13/h3-4,7-10,13H,5-6H2,1-2H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355801
PNG
(3-(3-Chloro-2-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1c(Cl)cccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-10-3-1-5-12(13(10)18)22-14-11(4-2-8-19-14)21-15(22)16(23)20-9-6-7-9/h1-5,8-9H,6-7H2,(H,20,23)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355798
PNG
(N-Cyclopropyl-3-[3-(trifluoromethoxy)phenyl]-3H-im...)
Show SMILES FC(F)(F)Oc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H13F3N4O2/c18-17(19,20)26-12-4-1-3-11(9-12)24-14-13(5-2-8-21-14)23-15(24)16(25)22-10-6-7-10/h1-5,8-10H,6-7H2,(H,22,25)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355757
PNG
(Azetidin-1-yl[3-(4-chloro-2-methylphenyl)-3H-imida...)
Show SMILES Cc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C17H15ClN4O/c1-11-10-12(18)5-6-14(11)22-15-13(4-2-7-19-15)20-16(22)17(23)21-8-3-9-21/h2,4-7,10H,3,8-9H2,1H3
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355734
PNG
(3-(4-Chloro-3-fluorophenyl)-N,N-dimethyl-3H-imidaz...)
Show SMILES CN(C)C(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C15H12ClFN4O/c1-20(2)15(22)14-19-12-4-3-7-18-13(12)21(14)9-5-6-10(16)11(17)8-9/h3-8H,1-2H3
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355760
PNG
(3-(5-Chloropyridin-3-yl)-N-cyclopropyl-3H-imidazo[...)
Show SMILES Clc1cncc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C15H12ClN5O/c16-9-6-11(8-17-7-9)21-13-12(2-1-5-18-13)20-14(21)15(22)19-10-3-4-10/h1-2,5-8,10H,3-4H2,(H,19,22)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355732
PNG
(Azetidin-1-yl[3-(4-chloro-3,5-difluorophenyl)-3H-i...)
Show SMILES Fc1cc(cc(F)c1Cl)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)7-9(8-11(13)19)23-14-12(3-1-4-20-14)21-15(23)16(24)22-5-2-6-22/h1,3-4,7-8H,2,5-6H2
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355793
PNG
(N-Cyclopropyl-3-(3-methylphenyl)-3H-imidazo[4,5-b]...)
Show SMILES Cc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O/c1-11-4-2-5-13(10-11)21-15-14(6-3-9-18-15)20-16(21)17(22)19-12-7-8-12/h2-6,9-10,12H,7-8H2,1H3,(H,19,22)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355724
PNG
(3-Cyclopentyl-N-cyclopropyl-3H-imidazo[4,5-b]pyrid...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1C1CCCC1
Show InChI InChI=1S/C15H18N4O/c20-15(17-10-7-8-10)14-18-12-6-3-9-16-13(12)19(14)11-4-1-2-5-11/h3,6,9-11H,1-2,4-5,7-8H2,(H,17,20)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355761
PNG
(Azetidin-1-yl[3-(5-chloropyridin-3-yl)-3H-imidazo[...)
Show SMILES Clc1cncc(c1)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C15H12ClN5O/c16-10-7-11(9-17-8-10)21-13-12(3-1-4-18-13)19-14(21)15(22)20-5-2-6-20/h1,3-4,7-9H,2,5-6H2
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355781
PNG
(N-Cyclopropyl-3-(4-methoxyphenyl)-3H-imidazo[4,5-b...)
Show SMILES COc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O2/c1-23-13-8-6-12(7-9-13)21-15-14(3-2-10-18-15)20-16(21)17(22)19-11-4-5-11/h2-3,6-11H,4-5H2,1H3,(H,19,22)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355750
PNG
(N-Cyclopropyl-3-(3,4-dichlorophenyl)-3H-imidazo[4,...)
Show SMILES Clc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12Cl2N4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355796
PNG
(N-Cyclopropyl-3-(2-methyl-1,3-benzothiazol-6-yl)-3...)
Show SMILES Cc1nc2ccc(cc2s1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H15N5OS/c1-10-20-13-7-6-12(9-15(13)25-10)23-16-14(3-2-8-19-16)22-17(23)18(24)21-11-4-5-11/h2-3,6-9,11H,4-5H2,1H3,(H,21,24)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355733
PNG
(Azetidin-1-yl[3-(4-chloro-3-fluorophenyl)-3H-imida...)
Show SMILES Fc1cc(ccc1Cl)-n1c(nc2cccnc12)C(Cl)(Cl)Cl
Show InChI InChI=1S/C13H6Cl4FN3/c14-8-4-3-7(6-9(8)18)21-11-10(2-1-5-19-11)20-12(21)13(15,16)17/h1-6H
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355790
PNG
(N-Cyclopropyl-3-(2-fluoro-4-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(c(F)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-4-7-14(12(18)9-10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
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n/an/a 619n/an/an/an/an/an/a



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US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355772
PNG
(3-(3-Chloro-4-methoxyphenyl)-N-cyclopropyl-3H-imid...)
Show SMILES COc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O2/c1-24-14-7-6-11(9-12(14)18)22-15-13(3-2-8-19-15)21-16(22)17(23)20-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,20,23)
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n/an/a 629n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355746
PNG
(3-(4-Chloro-2-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-9-3-6-13(11(18)8-9)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
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n/an/a 632n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355795
PNG
(N-Cyclopropyl-3-[3-(methylsulfanyl)phenyl]-3H-imid...)
Show SMILES CSc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4OS/c1-23-13-5-2-4-12(10-13)21-15-14(6-3-9-18-15)20-16(21)17(22)19-11-7-8-11/h2-6,9-11H,7-8H2,1H3,(H,19,22)
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Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355789
PNG
(N-Cyclopropyl-3-(3,5-dimethoxyphenyl)-3H-imidazo[4...)
Show SMILES COc1cc(OC)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O3/c1-24-13-8-12(9-14(10-13)25-2)22-16-15(4-3-7-19-16)21-17(22)18(23)20-11-5-6-11/h3-4,7-11H,5-6H2,1-2H3,(H,20,23)
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n/an/a 759n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355729
PNG
(3-(4-Chloro-3-fluorophenyl)-N-propyl-3H-imidazo[4,...)
Show SMILES CCCNC(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H14ClFN4O/c1-2-7-20-16(23)15-21-13-4-3-8-19-14(13)22(15)10-5-6-11(17)12(18)9-10/h3-6,8-9H,2,7H2,1H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355737
PNG
(3-Cyclopentyl-N-(1-methyl-1H-pyrazol-3-yl)-3H-imid...)
Show SMILES Cn1ccc(NC(=O)c2nc3cccnc3n2C2CCCC2)n1
Show InChI InChI=1S/C16H18N6O/c1-21-10-8-13(20-21)19-16(23)15-18-12-7-4-9-17-14(12)22(15)11-5-2-3-6-11/h4,7-11H,2-3,5-6H2,1H3,(H,19,20,23)
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Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355755
PNG
(3-(3-Chloro-4-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-8-10(5-6-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355726
PNG
(3-(4-Chloro-3-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1cc(ccc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355748
PNG
(US9815832, 25 | [3-(4-Chloro-2-fluorophenyl)-3H-im...)
Show SMILES FC1CN(C1)C(=O)c1nc2cccnc2n1-c1ccc(Cl)cc1F
Show InChI InChI=1S/C16H11ClF2N4O/c17-9-3-4-13(11(19)6-9)23-14-12(2-1-5-20-14)21-15(23)16(24)22-7-10(18)8-22/h1-6,10H,7-8H2
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355731
PNG
(4-[2-(Azetidin-1-ylcarbonyl)-3H-imidazo[4,5-b]pyri...)
Show SMILES Fc1cc(ccc1C#N)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C17H12FN5O/c18-13-9-12(5-4-11(13)10-19)23-15-14(3-1-6-20-15)21-16(23)17(24)22-7-2-8-22/h1,3-6,9H,2,7-8H2
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355766
PNG
(N-Cyclopropyl-3-(2,4-difluorophenyl)-3H-imidazo[4,...)
Show SMILES Fc1ccc(c(F)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F2N4O/c17-9-3-6-13(11(18)8-9)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355736
PNG
(3-(4-Chlorophenyl)-N-propyl-3H-imidazo[4,5-b]pyrid...)
Show SMILES CCCNC(=O)c1nc2cccnc2n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN4O/c1-2-9-19-16(22)15-20-13-4-3-10-18-14(13)21(15)12-7-5-11(17)6-8-12/h3-8,10H,2,9H2,1H3,(H,19,22)
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Pfizer Inc.

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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355782
PNG
(N-Cyclopropyl-3-(2,4-dimethylphenyl)-3H-imidazo[4,...)
Show SMILES Cc1ccc(c(C)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O/c1-11-5-8-15(12(2)10-11)22-16-14(4-3-9-19-16)21-17(22)18(23)20-13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H,20,23)
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Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355758
PNG
(US9815832, 35 | [3-(4-Chloro-2-methylphenyl)-3H-im...)
Show SMILES Cc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)N1CC(F)C1
Show InChI InChI=1S/C17H14ClFN4O/c1-10-7-11(18)4-5-14(10)23-15-13(3-2-6-20-15)21-16(23)17(24)22-8-12(19)9-22/h2-7,12H,8-9H2,1H3
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Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355800
PNG
(N-Cyclopropyl-3-[3-(trifluoromethyl)phenyl]-3H-imi...)
Show SMILES FC(F)(F)c1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H13F3N4O/c18-17(19,20)10-3-1-4-12(9-10)24-14-13(5-2-8-21-14)23-15(24)16(25)22-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,22,25)
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n/an/a 1.15E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355780
PNG
(N-Cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridine-2...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccccc1
Show InChI InChI=1S/C16H14N4O/c21-16(18-11-8-9-11)15-19-13-7-4-10-17-14(13)20(15)12-5-2-1-3-6-12/h1-7,10-11H,8-9H2,(H,18,21)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355764
PNG
(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl-3H-i...)
Show SMILES Fc1cc(c(F)cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-9-6-11(19)13(7-10(9)18)23-14-12(2-1-5-20-14)22-15(23)16(24)21-8-3-4-8/h1-2,5-8H,3-4H2,(H,21,24)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355783
PNG
(N-Cyclopropyl-3-(4-fluoro-2-methylphenyl)-3H-imida...)
Show SMILES Cc1cc(F)ccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-9-11(18)4-7-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-5-6-12/h2-4,7-9,12H,5-6H2,1H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355756
PNG
(3-(3-Chloro-4-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-7-12(9-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355770
PNG
(N-Cyclopropyl-3-(2,3-dihydro-1H-inden-2-yl)-3H-imi...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1C1Cc2ccccc2C1
Show InChI InChI=1S/C19H18N4O/c24-19(21-14-7-8-14)18-22-16-6-3-9-20-17(16)23(18)15-10-12-4-1-2-5-13(12)11-15/h1-6,9,14-15H,7-8,10-11H2,(H,21,24)
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n/an/a 1.26E+3n/an/an/an/an/an/a



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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355724
PNG
(3-Cyclopentyl-N-cyclopropyl-3H-imidazo[4,5-b]pyrid...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1C1CCCC1
Show InChI InChI=1S/C15H18N4O/c20-15(17-10-7-8-10)14-18-12-6-3-9-16-13(12)19(14)11-4-1-2-5-11/h3,6,9-11H,1-2,4-5,7-8H2,(H,17,20)
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Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355803
PNG
(N-Cyclopropyl-3-(quinolin-6-yl)-3H-imidazo[4,5-b]p...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2ncccc2c1
Show InChI InChI=1S/C19H15N5O/c25-19(22-13-5-6-13)18-23-16-4-2-10-21-17(16)24(18)14-7-8-15-12(11-14)3-1-9-20-15/h1-4,7-11,13H,5-6H2,(H,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
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UniChem
US Patent
n/an/a 1.47E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355785
PNG
(N-Cyclopropyl-3-(3,4-difluorophenyl)-3H-imidazo[4,...)
Show SMILES Fc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F2N4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
PDB

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n/an/a 1.49E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355735
PNG
(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-3H-i...)
Show SMILES Fc1cc(c(F)cc1Cl)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-9-7-11(19)13(8-10(9)18)23-14-12(3-1-4-20-14)21-15(23)16(24)22-5-2-6-22/h1,3-4,7-8H,2,5-6H2
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n/an/a 1.52E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355784
PNG
(N-Cyclopropyl-3-(1,3-dihydro-2-benzofuran-5-yl)-3H...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2COCc2c1
Show InChI InChI=1S/C18H16N4O2/c23-18(20-13-4-5-13)17-21-15-2-1-7-19-16(15)22(17)14-6-3-11-9-24-10-12(11)8-14/h1-3,6-8,13H,4-5,9-10H2,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
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UniChem
US Patent
n/an/a 1.58E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355767
PNG
(N-Cyclopropyl-3-(5-fluoro-2-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(F)cc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-4-5-11(18)9-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)
PDB

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GoogleScholar
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UniChem
US Patent
n/an/a 1.66E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355763
PNG
(3-(5-Cyano-2-fluorophenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Fc1ccc(cc1-n1c(nc2cccnc12)C(=O)NC1CC1)C#N
Show InChI InChI=1S/C17H12FN5O/c18-12-6-3-10(9-19)8-14(12)23-15-13(2-1-7-20-15)22-16(23)17(24)21-11-4-5-11/h1-3,6-8,11H,4-5H2,(H,21,24)
PDB

UniProtKB/SwissProt

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UniChem
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n/an/a 1.71E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355738
PNG
(N-Cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-3H-imid...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1C1CCOCC1
Show InChI InChI=1S/C15H18N4O2/c20-15(17-10-3-4-10)14-18-12-2-1-7-16-13(12)19(14)11-5-8-21-9-6-11/h1-2,7,10-11H,3-6,8-9H2,(H,17,20)
PDB

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UniChem
US Patent
n/an/a 1.73E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355802
PNG
(3-(5-Chloro-2-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1ccc(Cl)cc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-9-3-6-11(18)13(8-9)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
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n/an/a 1.76E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355730
PNG
(3-(4-Cyano-3-fluorophenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Fc1cc(ccc1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H12FN5O/c18-13-8-12(6-3-10(13)9-19)23-15-14(2-1-7-20-15)22-16(23)17(24)21-11-4-5-11/h1-3,6-8,11H,4-5H2,(H,21,24)
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n/an/a 1.88E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355792
PNG
(3-(3-Chlorophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]...)
Show SMILES Clc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13ClN4O/c17-10-3-1-4-12(9-10)21-14-13(5-2-8-18-14)20-15(21)16(22)19-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,19,22)
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n/an/a 1.91E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355797
PNG
(3-(4-Chloro-3-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1cc(ccc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-9-12(6-7-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-4-5-11/h2-3,6-9,11H,4-5H2,1H3,(H,20,23)
PDB

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n/an/a 1.99E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355741
PNG
(Azetidin-1-yl[3-(3-fluoro-4-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C17H15FN4O/c1-11-5-6-12(10-13(11)18)22-15-14(4-2-7-19-15)20-16(22)17(23)21-8-3-9-21/h2,4-7,10H,3,8-9H2,1H3
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n/an/a 2.14E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355723
PNG
(N-Cyclopropyl-3-(3-fluoro-4-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-4-7-12(9-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
PDB

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n/an/a 2.21E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355754
PNG
(3-(3-Cyano-4-fluorophenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Fc1ccc(cc1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H12FN5O/c18-13-6-5-12(8-10(13)9-19)23-15-14(2-1-7-20-15)22-16(23)17(24)21-11-3-4-11/h1-2,5-8,11H,3-4H2,(H,21,24)
PDB

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n/an/a 2.55E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355786
PNG
(N-Cyclopropyl-3-(3,5-dichlorophenyl)-3H-imidazo[4,...)
Show SMILES Clc1cc(Cl)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12Cl2N4O/c17-9-6-10(18)8-12(7-9)22-14-13(2-1-5-19-14)21-15(22)16(23)20-11-3-4-11/h1-2,5-8,11H,3-4H2,(H,20,23)
PDB

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n/an/a 2.55E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355810
PNG
(N-Cyclopropyl-3-(3,4-dimethoxyphenyl)-3H-imidazo[4...)
Show SMILES COc1ccc(cc1OC)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O3/c1-24-14-8-7-12(10-15(14)25-2)22-16-13(4-3-9-19-16)21-17(22)18(23)20-11-5-6-11/h3-4,7-11H,5-6H2,1-2H3,(H,20,23)
PDB

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n/an/a 2.72E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355815
PNG
(N-Cyclopropyl-3-[4-(trifluoromethyl)phenyl]-3H-imi...)
Show SMILES FC(F)(F)c1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H13F3N4O/c18-17(19,20)10-3-7-12(8-4-10)24-14-13(2-1-9-21-14)23-15(24)16(25)22-11-5-6-11/h1-4,7-9,11H,5-6H2,(H,22,25)
PDB

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n/an/a 3.11E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355776
PNG
(3-(3-Cyanophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]p...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1cccc(c1)C#N
Show InChI InChI=1S/C17H13N5O/c18-10-11-3-1-4-13(9-11)22-15-14(5-2-8-19-15)21-16(22)17(23)20-12-6-7-12/h1-5,8-9,12H,6-7H2,(H,20,23)
PDB

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n/an/a 3.40E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355812
PNG
(N-Cyclopropyl-3-(4-methoxy-2-methylphenyl)-3H-imid...)
Show SMILES COc1ccc(c(C)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O2/c1-11-10-13(24-2)7-8-15(11)22-16-14(4-3-9-19-16)21-17(22)18(23)20-12-5-6-12/h3-4,7-10,12H,5-6H2,1-2H3,(H,20,23)
PDB

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n/an/a 3.52E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355811
PNG
(3-(2-Chloro-4-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(c(Cl)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-7-14(12(18)9-10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
PDB

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n/an/a 3.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355798
PNG
(N-Cyclopropyl-3-[3-(trifluoromethoxy)phenyl]-3H-im...)
Show SMILES FC(F)(F)Oc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H13F3N4O2/c18-17(19,20)26-12-4-1-3-11(9-12)24-14-13(5-2-8-21-14)23-15(24)16(25)22-10-6-7-10/h1-5,8-10H,6-7H2,(H,22,25)
PDB

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n/an/a 3.98E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355737
PNG
(3-Cyclopentyl-N-(1-methyl-1H-pyrazol-3-yl)-3H-imid...)
Show SMILES Cn1ccc(NC(=O)c2nc3cccnc3n2C2CCCC2)n1
Show InChI InChI=1S/C16H18N6O/c1-21-10-8-13(20-21)19-16(23)15-18-12-7-4-9-17-14(12)22(15)11-5-2-3-6-11/h4,7-11H,2-3,5-6H2,1H3,(H,19,20,23)
PDB

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n/an/a 4.38E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355771
PNG
(N-Cyclopropyl-3-(3,5-difluorophenyl)-3H-imidazo[4,...)
Show SMILES Fc1cc(F)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F2N4O/c17-9-6-10(18)8-12(7-9)22-14-13(2-1-5-19-14)21-15(22)16(23)20-11-3-4-11/h1-2,5-8,11H,3-4H2,(H,20,23)
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US Patent
n/an/a 4.82E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355779
PNG
(3-(3-Cyano-4-methylphenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Cc1ccc(cc1C#N)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H15N5O/c1-11-4-7-14(9-12(11)10-19)23-16-15(3-2-8-20-16)22-17(23)18(24)21-13-5-6-13/h2-4,7-9,13H,5-6H2,1H3,(H,21,24)
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n/an/a 4.85E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355742
PNG
((3-Fluoroazetidin-1-yl)[3-(3-fluoro-4-methylphenyl...)
Show SMILES Cc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)N1CC(F)C1
Show InChI InChI=1S/C17H14F2N4O/c1-10-4-5-12(7-13(10)19)23-15-14(3-2-6-20-15)21-16(23)17(24)22-8-11(18)9-22/h2-7,11H,8-9H2,1H3
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n/an/a 5.28E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355739
PNG
(Azetidin-1-yl[3-(4-chlorophenyl)-3H-imidazo[4,5-b]...)
Show SMILES Clc1ccc(cc1)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H13ClN4O/c17-11-4-6-12(7-5-11)21-14-13(3-1-8-18-14)19-15(21)16(22)20-9-2-10-20/h1,3-8H,2,9-10H2
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n/an/a 5.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355745
PNG
(Azetidin-1-yl[3-(4-chloro-2-fluorophenyl)-3H-imida...)
Show SMILES Fc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H12ClFN4O/c17-10-4-5-13(11(18)9-10)22-14-12(3-1-6-19-14)20-15(22)16(23)21-7-2-8-21/h1,3-6,9H,2,7-8H2
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n/an/a 5.59E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355728
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1ccc(NC(=O)c2nc3cccnc3n2-c2ccc(Cl)c(F)c2)n1
Show InChI InChI=1S/C17H12ClFN6O/c1-24-8-6-14(23-24)22-17(26)16-21-13-3-2-7-20-15(13)25(16)10-4-5-11(18)12(19)9-10/h2-9H,1H3,(H,22,23,26)
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n/an/a 5.64E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355748
PNG
(US9815832, 25 | [3-(4-Chloro-2-fluorophenyl)-3H-im...)
Show SMILES FC1CN(C1)C(=O)c1nc2cccnc2n1-c1ccc(Cl)cc1F
Show InChI InChI=1S/C16H11ClF2N4O/c17-9-3-4-13(11(19)6-9)23-14-12(2-1-5-20-14)21-15(23)16(24)22-7-10(18)8-22/h1-6,10H,7-8H2
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n/an/a 5.84E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355805
PNG
(N-Cyclopropyl-3-[2-(trifluoromethyl)pyridin-4-yl]-...)
Show SMILES FC(F)(F)c1cc(ccn1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F3N5O/c17-16(18,19)12-8-10(5-7-20-12)24-13-11(2-1-6-21-13)23-14(24)15(25)22-9-3-4-9/h1-2,5-9H,3-4H2,(H,22,25)
PDB

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n/an/a 6.07E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355794
PNG
(3-(1,3-Benzothiazol-6-yl)-N-cyclopropyl-3H-imidazo...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H13N5OS/c23-17(20-10-3-4-10)16-21-13-2-1-7-18-15(13)22(16)11-5-6-12-14(8-11)24-9-19-12/h1-2,5-10H,3-4H2,(H,20,23)
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n/an/a 6.34E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355770
PNG
(N-Cyclopropyl-3-(2,3-dihydro-1H-inden-2-yl)-3H-imi...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1C1Cc2ccccc2C1
Show InChI InChI=1S/C19H18N4O/c24-19(21-14-7-8-14)18-22-16-6-3-9-20-17(16)23(18)15-10-12-4-1-2-5-13(12)11-15/h1-6,9,14-15H,7-8,10-11H2,(H,21,24)
PDB

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n/an/a 6.39E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355736
PNG
(3-(4-Chlorophenyl)-N-propyl-3H-imidazo[4,5-b]pyrid...)
Show SMILES CCCNC(=O)c1nc2cccnc2n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN4O/c1-2-9-19-16(22)15-20-13-4-3-10-18-14(13)21(15)12-7-5-11(17)6-8-12/h3-8,10H,2,9H2,1H3,(H,19,22)
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n/an/a 6.64E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355761
PNG
(Azetidin-1-yl[3-(5-chloropyridin-3-yl)-3H-imidazo[...)
Show SMILES Clc1cncc(c1)-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C15H12ClN5O/c16-10-7-11(9-17-8-10)21-13-12(3-1-4-18-13)19-14(21)15(22)20-5-2-6-20/h1,3-4,7-9H,2,5-6H2
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n/an/a 6.67E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355738
PNG
(N-Cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-3H-imid...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1C1CCOCC1
Show InChI InChI=1S/C15H18N4O2/c20-15(17-10-3-4-10)14-18-12-2-1-7-16-13(12)19(14)11-5-8-21-9-6-11/h1-2,7,10-11H,3-6,8-9H2,(H,17,20)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355808
PNG
(N-Cyclopropyl-3-(6-methylpyridin-3-yl)-3H-imidazo[...)
Show SMILES Cc1ccc(cn1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H15N5O/c1-10-4-7-12(9-18-10)21-14-13(3-2-8-17-14)20-15(21)16(22)19-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,19,22)
PDB

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n/an/a 7.73E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355725
PNG
(3-(4-Chlorophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]...)
Show SMILES Clc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13ClN4O/c17-10-3-7-12(8-4-10)21-14-13(2-1-9-18-14)20-15(21)16(22)19-11-5-6-11/h1-4,7-9,11H,5-6H2,(H,19,22)
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n/an/a 7.95E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355751
PNG
(N-Cyclopropyl-3-(4-fluoro-3-methylphenyl)-3H-imida...)
Show SMILES Cc1cc(ccc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-9-12(6-7-13(10)18)22-15-14(3-2-8-19-15)21-16(22)17(23)20-11-4-5-11/h2-3,6-9,11H,4-5H2,1H3,(H,20,23)
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n/an/a 8.23E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355804
PNG
(3-(5-Chloropyridin-3-yl)-N-ethyl-3H-imidazo[4,5-b]...)
Show SMILES CCNC(=O)c1nc2cccnc2n1-c1cncc(Cl)c1
Show InChI InChI=1S/C14H12ClN5O/c1-2-17-14(21)13-19-11-4-3-5-18-12(11)20(13)10-6-9(15)7-16-8-10/h3-8H,2H2,1H3,(H,17,21)
PDB

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n/an/a 8.27E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355758
PNG
(US9815832, 35 | [3-(4-Chloro-2-methylphenyl)-3H-im...)
Show SMILES Cc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)N1CC(F)C1
Show InChI InChI=1S/C17H14ClFN4O/c1-10-7-11(18)4-5-14(10)23-15-13(3-2-6-20-15)21-16(23)17(24)22-8-12(19)9-22/h2-7,12H,8-9H2,1H3
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n/an/a 8.28E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355740
PNG
(3-(4-Chloro-3-fluorophenyl)-3H-imidazo[4,5-b]pyrid...)
Show SMILES NC(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C13H8ClFN4O/c14-8-4-3-7(6-9(8)15)19-12-10(2-1-5-17-12)18-13(19)11(16)20/h1-6H,(H2,16,20)
PDB

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n/an/a 8.51E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355800
PNG
(N-Cyclopropyl-3-[3-(trifluoromethyl)phenyl]-3H-imi...)
Show SMILES FC(F)(F)c1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H13F3N4O/c18-17(19,20)10-3-1-4-12(9-10)24-14-13(5-2-8-21-14)23-15(24)16(25)22-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,22,25)
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n/an/a 8.64E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355813
PNG
(3-(2-Chloro-5-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1ccc(Cl)c(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(18)8-13(11)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
PDB

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n/an/a 9.23E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355814
PNG
(3-(2-Chloro-5-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(Cl)c(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-7-12(18)14(9-10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
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n/an/a 9.42E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355734
PNG
(3-(4-Chloro-3-fluorophenyl)-N,N-dimethyl-3H-imidaz...)
Show SMILES CN(C)C(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C15H12ClFN4O/c1-20(2)15(22)14-19-12-4-3-7-18-13(12)21(14)9-5-6-10(16)11(17)8-9/h3-8H,1-2H3
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UniChem
US Patent
n/an/a 9.64E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355762
PNG
(3-(6-Cyanopyridin-3-yl)-N-cyclopropyl-3H-imidazo[4...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc(nc1)C#N
Show InChI InChI=1S/C16H12N6O/c17-8-11-5-6-12(9-19-11)22-14-13(2-1-7-18-14)21-15(22)16(23)20-10-3-4-10/h1-2,5-7,9-10H,3-4H2,(H,20,23)
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US Patent
n/an/a 1.02E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355757
PNG
(Azetidin-1-yl[3-(4-chloro-2-methylphenyl)-3H-imida...)
Show SMILES Cc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)N1CCC1
Show InChI InChI=1S/C17H15ClN4O/c1-11-10-12(18)5-6-14(11)22-15-13(4-2-7-19-15)20-16(22)17(23)21-8-3-9-21/h2,4-7,10H,3,8-9H2,1H3
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US Patent
n/an/a 1.02E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355760
PNG
(3-(5-Chloropyridin-3-yl)-N-cyclopropyl-3H-imidazo[...)
Show SMILES Clc1cncc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C15H12ClN5O/c16-9-6-11(8-17-7-9)21-13-12(2-1-5-18-13)20-14(21)15(22)19-10-3-4-10/h1-2,5-8,10H,3-4H2,(H,19,22)
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US Patent
n/an/a 1.07E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355788
PNG
(N-Cyclopropyl-3-(3-fluorophenyl)-3H-imidazo[4,5-b]...)
Show SMILES Fc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13FN4O/c17-10-3-1-4-12(9-10)21-14-13(5-2-8-18-14)20-15(21)16(22)19-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,19,22)
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US Patent
n/an/a 1.09E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355801
PNG
(3-(3-Chloro-2-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1c(Cl)cccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-10-3-1-5-12(13(10)18)22-14-11(4-2-8-19-14)21-15(22)16(23)20-9-6-7-9/h1-5,8-9H,6-7H2,(H,20,23)
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n/an/a 1.14E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355791
PNG
(N-Cyclopropyl-3-(4-fluorophenyl)-3H-imidazo[4,5-b]...)
Show SMILES Fc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13FN4O/c17-10-3-7-12(8-4-10)21-14-13(2-1-9-18-14)20-15(21)16(22)19-11-5-6-11/h1-4,7-9,11H,5-6H2,(H,19,22)
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US Patent
n/an/a 1.19E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355772
PNG
(3-(3-Chloro-4-methoxyphenyl)-N-cyclopropyl-3H-imid...)
Show SMILES COc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O2/c1-24-14-7-6-11(9-12(14)18)22-15-13(3-2-8-19-15)21-16(22)17(23)20-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,20,23)
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US Patent
n/an/a 1.23E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355796
PNG
(N-Cyclopropyl-3-(2-methyl-1,3-benzothiazol-6-yl)-3...)
Show SMILES Cc1nc2ccc(cc2s1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H15N5OS/c1-10-20-13-7-6-12(9-15(13)25-10)23-16-14(3-2-8-19-16)22-17(23)18(24)21-11-4-5-11/h2-3,6-9,11H,4-5H2,1H3,(H,21,24)
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n/an/a 1.26E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355774
PNG
(N-Cyclopropyl-3-(4-methoxy-3-methylphenyl)-3H-imid...)
Show SMILES COc1ccc(cc1C)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O2/c1-11-10-13(7-8-15(11)24-2)22-16-14(4-3-9-19-16)21-17(22)18(23)20-12-5-6-12/h3-4,7-10,12H,5-6H2,1-2H3,(H,20,23)
PDB

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US Patent
n/an/a 1.32E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355806
PNG
(N-Cyclopropyl-3-(5-methoxypyridin-3-yl)-3H-imidazo...)
Show SMILES COc1cncc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H15N5O2/c1-23-12-7-11(8-17-9-12)21-14-13(3-2-6-18-14)20-15(21)16(22)19-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,19,22)
PDB

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UniChem
US Patent
n/an/a 1.36E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355769
PNG
(N-Cyclopropyl-3-(3-methoxyphenyl)-3H-imidazo[4,5-b...)
Show SMILES COc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O2/c1-23-13-5-2-4-12(10-13)21-15-14(6-3-9-18-15)20-16(21)17(22)19-11-7-8-11/h2-6,9-11H,7-8H2,1H3,(H,19,22)
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n/an/a 1.38E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355768
PNG
(N-Cyclopropyl-3-(3-fluoro-4-methoxyphenyl)-3H-imid...)
Show SMILES COc1ccc(cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O2/c1-24-14-7-6-11(9-12(14)18)22-15-13(3-2-8-19-15)21-16(22)17(23)20-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,20,23)
PDB

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n/an/a 1.48E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355793
PNG
(N-Cyclopropyl-3-(3-methylphenyl)-3H-imidazo[4,5-b]...)
Show SMILES Cc1cccc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O/c1-11-4-2-5-13(10-11)21-15-14(6-3-9-18-15)20-16(21)17(22)19-12-7-8-12/h2-6,9-10,12H,7-8H2,1H3,(H,19,22)
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n/an/a 1.49E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355763
PNG
(3-(5-Cyano-2-fluorophenyl)-N-cyclopropyl-3H-imidaz...)
Show SMILES Fc1ccc(cc1-n1c(nc2cccnc12)C(=O)NC1CC1)C#N
Show InChI InChI=1S/C17H12FN5O/c18-12-6-3-10(9-19)8-14(12)23-15-13(2-1-7-20-15)22-16(23)17(24)21-11-4-5-11/h1-3,6-8,11H,4-5H2,(H,21,24)
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n/an/a 1.52E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355787
PNG
(N-Cyclopropyl-3-(2,3-dihydro-1H-inden-5-yl)-3H-imi...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2CCCc2c1
Show InChI InChI=1S/C19H18N4O/c24-19(21-14-7-8-14)18-22-16-5-2-10-20-17(16)23(18)15-9-6-12-3-1-4-13(12)11-15/h2,5-6,9-11,14H,1,3-4,7-8H2,(H,21,24)
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n/an/a 1.57E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355807
PNG
(3-(2-Chloro-4-fluoro-5-methylphenyl)-N-cyclopropyl...)
Show SMILES Cc1cc(c(Cl)cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H14ClFN4O/c1-9-7-14(11(18)8-12(9)19)23-15-13(3-2-6-20-15)22-16(23)17(24)21-10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,21,24)
PDB

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n/an/a 1.66E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355805
PNG
(N-Cyclopropyl-3-[2-(trifluoromethyl)pyridin-4-yl]-...)
Show SMILES FC(F)(F)c1cc(ccn1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F3N5O/c17-16(18,19)12-8-10(5-7-20-12)24-13-11(2-1-6-21-13)23-14(24)15(25)22-9-3-4-9/h1-2,5-9H,3-4H2,(H,22,25)
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n/an/a 1.75E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355749
PNG
(3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-9-11(18)4-7-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-5-6-12/h2-4,7-9,12H,5-6H2,1H3,(H,20,23)
PDB

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n/an/a>1.79E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355799
PNG
(N-Cyclopropyl-3-(3,5-dimethylphenyl)-3H-imidazo[4,...)
Show SMILES Cc1cc(C)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O/c1-11-8-12(2)10-14(9-11)22-16-15(4-3-7-19-16)21-17(22)18(23)20-13-5-6-13/h3-4,7-10,13H,5-6H2,1-2H3,(H,20,23)
PDB

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n/an/a>1.88E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355777
PNG
(3-(5-Chloro-2-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(Cl)cc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-5-11(18)9-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)
PDB

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n/an/a 1.92E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355789
PNG
(N-Cyclopropyl-3-(3,5-dimethoxyphenyl)-3H-imidazo[4...)
Show SMILES COc1cc(OC)cc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O3/c1-24-13-8-12(9-14(10-13)25-2)22-16-15(4-3-7-19-16)21-17(22)18(23)20-11-5-6-11/h3-4,7-11H,5-6H2,1-2H3,(H,20,23)
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n/an/a 1.94E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355780
PNG
(N-Cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridine-2...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccccc1
Show InChI InChI=1S/C16H14N4O/c21-16(18-11-8-9-11)15-19-13-7-4-10-17-14(13)20(15)12-5-2-1-3-6-12/h1-7,10-11H,8-9H2,(H,18,21)
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n/an/a>1.97E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355765
PNG
(3-(4-Cyanophenyl)-N-cyclopropyl-3H-imidazo[4,5-b]p...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc(cc1)C#N
Show InChI InChI=1S/C17H13N5O/c18-10-11-3-7-13(8-4-11)22-15-14(2-1-9-19-15)21-16(22)17(23)20-12-5-6-12/h1-4,7-9,12H,5-6H2,(H,20,23)
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n/an/a>2.24E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355778
PNG
(N-Cyclopropyl-3-(4-fluoro-3-methoxyphenyl)-3H-imid...)
Show SMILES COc1cc(ccc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O2/c1-24-14-9-11(6-7-12(14)18)22-15-13(3-2-8-19-15)21-16(22)17(23)20-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,20,23)
PDB

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n/an/a>2.37E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355747
PNG
(3-(4-Chlorophenyl)-N-(1-methyl-1H-pyrazol-3-yl)-3H...)
Show SMILES Cn1ccc(NC(=O)c2nc3cccnc3n2-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C17H13ClN6O/c1-23-10-8-14(22-23)21-17(25)16-20-13-3-2-9-19-15(13)24(16)12-6-4-11(18)5-7-12/h2-10H,1H3,(H,21,22,25)
PDB

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n/an/a>2.41E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355809
PNG
(N-Cyclopropyl-3-(1-methyl-1H-indazol-6-yl)-3H-imid...)
Show SMILES Cn1ncc2ccc(cc12)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16N6O/c1-23-15-9-13(7-4-11(15)10-20-23)24-16-14(3-2-8-19-16)22-17(24)18(25)21-12-5-6-12/h2-4,7-10,12H,5-6H2,1H3,(H,21,25)
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a 2.45E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355775
PNG
(N-Cyclopropyl-3-(3,4-dimethylphenyl)-3H-imidazo[4,...)
Show SMILES Cc1ccc(cc1C)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O/c1-11-5-8-14(10-12(11)2)22-16-15(4-3-9-19-16)21-17(22)18(23)20-13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H,20,23)
PDB

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n/an/a 2.58E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355766
PNG
(N-Cyclopropyl-3-(2,4-difluorophenyl)-3H-imidazo[4,...)
Show SMILES Fc1ccc(c(F)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12F2N4O/c17-9-3-6-13(11(18)8-9)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
PDB

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n/an/a>2.66E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355752
PNG
(N-Cyclopropyl-3-(4-methylphenyl)-3H-imidazo[4,5-b]...)
Show SMILES Cc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O/c1-11-4-8-13(9-5-11)21-15-14(3-2-10-18-15)20-16(21)17(22)19-12-6-7-12/h2-5,8-10,12H,6-7H2,1H3,(H,19,22)
PDB

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n/an/a>2.80E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355767
PNG
(N-Cyclopropyl-3-(5-fluoro-2-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(F)cc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-4-5-11(18)9-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)
PDB

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n/an/a>2.90E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355806
PNG
(N-Cyclopropyl-3-(5-methoxypyridin-3-yl)-3H-imidazo...)
Show SMILES COc1cncc(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H15N5O2/c1-23-12-7-11(8-17-9-12)21-14-13(3-2-6-18-14)20-15(21)16(22)19-10-4-5-10/h2-3,6-10H,4-5H2,1H3,(H,19,22)
PDB

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n/an/a>2.93E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355784
PNG
(N-Cyclopropyl-3-(1,3-dihydro-2-benzofuran-5-yl)-3H...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2COCc2c1
Show InChI InChI=1S/C18H16N4O2/c23-18(20-13-4-5-13)17-21-15-2-1-7-19-16(15)22(17)14-6-3-11-9-24-10-12(11)8-14/h1-3,6-8,13H,4-5,9-10H2,(H,20,23)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355782
PNG
(N-Cyclopropyl-3-(2,4-dimethylphenyl)-3H-imidazo[4,...)
Show SMILES Cc1ccc(c(C)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O/c1-11-5-8-15(12(2)10-11)22-16-14(4-3-9-19-16)21-17(22)18(23)20-13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H,20,23)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355803
PNG
(N-Cyclopropyl-3-(quinolin-6-yl)-3H-imidazo[4,5-b]p...)
Show SMILES O=C(NC1CC1)c1nc2cccnc2n1-c1ccc2ncccc2c1
Show InChI InChI=1S/C19H15N5O/c25-19(22-13-5-6-13)18-23-16-4-2-10-21-17(16)24(18)14-7-8-15-12(11-14)3-1-9-20-15/h1-4,7-11,13H,5-6H2,(H,22,25)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355740
PNG
(3-(4-Chloro-3-fluorophenyl)-3H-imidazo[4,5-b]pyrid...)
Show SMILES NC(=O)c1nc2cccnc2n1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C13H8ClFN4O/c14-8-4-3-7(6-9(8)15)19-12-10(2-1-5-17-12)18-13(19)11(16)20/h1-6H,(H2,16,20)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355810
PNG
(N-Cyclopropyl-3-(3,4-dimethoxyphenyl)-3H-imidazo[4...)
Show SMILES COc1ccc(cc1OC)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O3/c1-24-14-8-7-12(10-15(14)25-2)22-16-13(4-3-9-19-16)21-17(22)18(23)20-11-5-6-11/h3-4,7-11H,5-6H2,1-2H3,(H,20,23)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355773
PNG
(N-Cyclopropyl-3-(3-methoxy-4-methylphenyl)-3H-imid...)
Show SMILES COc1cc(ccc1C)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O2/c1-11-5-8-13(10-15(11)24-2)22-16-14(4-3-9-19-16)21-17(22)18(23)20-12-6-7-12/h3-5,8-10,12H,6-7H2,1-2H3,(H,20,23)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355781
PNG
(N-Cyclopropyl-3-(4-methoxyphenyl)-3H-imidazo[4,5-b...)
Show SMILES COc1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16N4O2/c1-23-13-8-6-12(7-9-13)21-15-14(3-2-10-18-15)20-16(21)17(22)19-11-4-5-11/h2-3,6-11H,4-5H2,1H3,(H,19,22)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355813
PNG
(3-(2-Chloro-5-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1ccc(Cl)c(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(18)8-13(11)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355808
PNG
(N-Cyclopropyl-3-(6-methylpyridin-3-yl)-3H-imidazo[...)
Show SMILES Cc1ccc(cn1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H15N5O/c1-10-4-7-12(9-18-10)21-14-13(3-2-8-17-14)20-15(21)16(22)19-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,19,22)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355811
PNG
(3-(2-Chloro-4-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(c(Cl)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-7-14(12(18)9-10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355807
PNG
(3-(2-Chloro-4-fluoro-5-methylphenyl)-N-cyclopropyl...)
Show SMILES Cc1cc(c(Cl)cc1F)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H14ClFN4O/c1-9-7-14(11(18)8-12(9)19)23-15-13(3-2-6-20-15)22-16(23)17(24)21-10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,21,24)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355809
PNG
(N-Cyclopropyl-3-(1-methyl-1H-indazol-6-yl)-3H-imid...)
Show SMILES Cn1ncc2ccc(cc12)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16N6O/c1-23-15-9-13(7-4-11(15)10-20-23)24-16-14(3-2-8-19-16)22-17(24)18(25)21-12-5-6-12/h2-4,7-10,12H,5-6H2,1H3,(H,21,25)
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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355746
PNG
(3-(4-Chloro-2-fluorophenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Fc1cc(Cl)ccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-9-3-6-13(11(18)8-9)22-14-12(2-1-7-19-14)21-15(22)16(23)20-10-4-5-10/h1-3,6-8,10H,4-5H2,(H,20,23)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355790
PNG
(N-Cyclopropyl-3-(2-fluoro-4-methylphenyl)-3H-imida...)
Show SMILES Cc1ccc(c(F)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-4-7-14(12(18)9-10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355814
PNG
(3-(2-Chloro-5-methylphenyl)-N-cyclopropyl-3H-imida...)
Show SMILES Cc1ccc(Cl)c(c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-4-7-12(18)14(9-10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,20,23)
PDB

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UniProtKB/SwissProt

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355783
PNG
(N-Cyclopropyl-3-(4-fluoro-2-methylphenyl)-3H-imida...)
Show SMILES Cc1cc(F)ccc1-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-9-11(18)4-7-14(10)22-15-13(3-2-8-19-15)21-16(22)17(23)20-12-5-6-12/h2-4,7-9,12H,5-6H2,1H3,(H,20,23)
PDB

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UniProtKB/SwissProt

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355804
PNG
(3-(5-Chloropyridin-3-yl)-N-ethyl-3H-imidazo[4,5-b]...)
Show SMILES CCNC(=O)c1nc2cccnc2n1-c1cncc(Cl)c1
Show InChI InChI=1S/C14H12ClN5O/c1-2-17-14(21)13-19-11-4-3-5-18-12(11)20(13)10-6-9(15)7-16-8-10/h3-8H,2H2,1H3,(H,17,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355815
PNG
(N-Cyclopropyl-3-[4-(trifluoromethyl)phenyl]-3H-imi...)
Show SMILES FC(F)(F)c1ccc(cc1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H13F3N4O/c18-17(19,20)10-3-7-12(8-4-10)24-14-13(2-1-9-21-14)23-15(24)16(25)22-11-5-6-11/h1-4,7-9,11H,5-6H2,(H,22,25)
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UniProtKB/SwissProt

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE4D)


(Homo sapiens (Human))		BDBM355812
PNG
(N-Cyclopropyl-3-(4-methoxy-2-methylphenyl)-3H-imid...)
Show SMILES COc1ccc(c(C)c1)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H18N4O2/c1-11-10-13(24-2)7-8-15(11)22-16-14(4-3-9-19-16)21-17(22)18(23)20-12-5-6-12/h3-4,7-10,12H,5-6H2,1-2H3,(H,20,23)
PDB

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UniProtKB/SwissProt

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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%