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Patent code US9815834

Compile Data Set for Download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287008
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C24H25Cl2N5O5/c1-5-18(32)30-11-14(12-30)36-7-6-31-22-13(10-28-24(27-2)29-22)8-15(23(31)33)19-20(25)16(34-3)9-17(35-4)21(19)26/h5,8-10,14H,1,6-7,11-12H2,2-4H3,(H,27,28,29)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287520
PNG
(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCN(C)C2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C24H26Cl2N6O4/c1-5-18(33)31-11-14(12-31)30(2)6-7-32-22-13(10-28-24(27)29-22)8-15(23(32)34)19-20(25)16(35-3)9-17(36-4)21(19)26/h5,8-10,14H,1,6-7,11-12H2,2-4H3,(H2,27,28,29)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287526
PNG
((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)e...)
Show SMILES COC[C@@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H34Cl2N6O5/c1-7-22(37)35-13-18(14-35)34(3)8-9-36-26-17(12-31-28(33-26)32-16(2)15-39-4)10-19(27(36)38)23-24(29)20(40-5)11-21(41-6)25(23)30/h7,10-12,16,18H,1,8-9,13-15H2,2-6H3,(H,31,32,33)/t16-/m1/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286388
PNG
(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C25H28Cl2N6O4/c1-5-19(34)32-9-6-31(7-10-32)8-11-33-23-15(14-29-25(28-2)30-23)12-16(24(33)35)20-21(26)17(36-3)13-18(37-4)22(20)27/h5,12-14H,1,6-11H2,2-4H3,(H,28,29,30)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287005
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C27H32Cl2N6O5/c1-4-21(37)34-11-9-33(10-12-34)7-5-8-35-25-17(16-31-27(32-25)30-6-13-36)14-18(26(35)38)22-23(28)19(39-2)15-20(40-3)24(22)29/h4,14-16,36H,1,5-13H2,2-3H3,(H,30,31,32)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286977
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H31ClN6O4/c1-5-22(34)32-11-9-31(10-12-32)7-6-8-33-24-17(16-29-26(28-2)30-24)13-20(25(33)35)19-14-18(36-3)15-21(37-4)23(19)27/h5,13-16H,1,6-12H2,2-4H3,(H,28,29,30)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287538
PNG
(8-(2-((1-acryloylazetidin-3-yl)(2-methoxyethyl)ami...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(CCOC)C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H32Cl2N6O5/c1-6-21(36)34-14-17(15-34)33(9-10-38-3)7-8-35-25-16(13-31-27(30-2)32-25)11-18(26(35)37)22-23(28)19(39-4)12-20(40-5)24(22)29/h6,11-13,17H,1,7-10,14-15H2,2-5H3,(H,30,31,32)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287508
PNG
(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(3)8-9-34-24-15(12-30-26(31-24)29-7-2)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286978
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H37ClN6O5/c1-6-24(37)35-12-10-34(11-13-35)8-7-9-36-26-19(17-31-28(33-26)32-18-29(2,3)39)14-22(27(36)38)21-15-20(40-4)16-23(41-5)25(21)30/h6,14-17,39H,1,7-13,18H2,2-5H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287541
PNG
(8-(2-((1-acryloylazetidin-3-yl)(2-methoxyethyl)ami...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(CCOC)C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H34Cl2N6O5/c1-6-22(37)35-15-18(16-35)34(10-11-39-3)8-9-36-26-17(14-32-28(33-26)31-7-2)12-19(27(36)38)23-24(29)20(40-4)13-21(41-5)25(23)30/h6,12-14,18H,1,7-11,15-16H2,2-5H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286999
PNG
(8-((1-((4-acryloylpiperazin-1-yl)methyl)cyclopropy...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CC3(CN4CCN(CC4)C(=O)C=C)CC3)c2n1
Show InChI InChI=1S/C28H32Cl2N6O4/c1-5-21(37)35-10-8-34(9-11-35)15-28(6-7-28)16-36-25-17(14-32-27(31-2)33-25)12-18(26(36)38)22-23(29)19(39-3)13-20(40-4)24(22)30/h5,12-14H,1,6-11,15-16H2,2-4H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287012
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H36Cl2N6O5/c1-4-24(39)37-12-10-36(11-13-37)8-5-9-38-28-19(18-33-30(35-28)34-20-6-14-43-15-7-20)16-21(29(38)40)25-26(31)22(41-2)17-23(42-3)27(25)32/h4,16-18,20H,1,5-15H2,2-3H3,(H,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286998
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-21(36)34-12-10-33(11-13-34)8-7-9-35-25-17(16-31-27(32-25)30-6-2)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,14-16H,1,6-13H2,2-4H3,(H,30,31,32)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286995
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C31H32Cl2N6O4/c1-4-25(40)38-15-13-37(14-16-38)11-8-12-39-29-20(19-34-31(36-29)35-21-9-6-5-7-10-21)17-22(30(39)41)26-27(32)23(42-2)18-24(43-3)28(26)33/h4-7,9-10,17-19H,1,8,11-16H2,2-3H3,(H,34,35,36)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287018
PNG
((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES COC[C@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-23(38)36-12-10-35(11-13-36)8-7-9-37-27-19(16-32-29(34-27)33-18(2)17-40-3)14-20(28(37)39)24-25(30)21(41-4)15-22(42-5)26(24)31/h6,14-16,18H,1,7-13,17H2,2-5H3,(H,32,33,34)/t18-/m0/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287511
PNG
(8-(2-((1-acryloylazetidin-3-yl)(ethyl)amino)ethyl)...)
Show SMILES CCN(CCn1c2nc(NC)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(7-2)8-9-34-24-15(12-30-26(29-3)31-24)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287542
PNG
(1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)
Show SMILES CNc1cc2n(CCOC3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C25H26Cl2N4O5/c1-5-21(32)30-12-15(13-30)36-7-6-31-17-9-20(28-2)29-11-14(17)8-16(25(31)33)22-23(26)18(34-3)10-19(35-4)24(22)27/h5,8-11,15H,1,6-7,12-13H2,2-4H3,(H,28,29)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286523
PNG
(8-(2-((1-acryloylpyrrolidin-3-yl)oxy)ethyl)-6-(2,6...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C25H27Cl2N5O5/c1-5-19(33)31-7-6-15(13-31)37-9-8-32-23-14(12-29-25(28-2)30-23)10-16(24(32)34)20-21(26)17(35-3)11-18(36-4)22(20)27/h5,10-12,15H,1,6-9,13H2,2-4H3,(H,28,29,30)
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n/an/a 2.20n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287535
PNG
(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)nc2n(CCN(C)C2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H37Cl2N7O5/c1-5-24(40)38-17-20(18-38)36(2)8-9-39-28-19(16-34-30(35-28)33-6-7-37-10-12-44-13-11-37)14-21(29(39)41)25-26(31)22(42-3)15-23(43-4)27(25)32/h5,14-16,20H,1,6-13,17-18H2,2-4H3,(H,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287007
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H37ClN6O5/c1-4-26(38)36-12-10-35(11-13-36)8-5-9-37-28-20(19-32-30(34-28)33-21-6-14-42-15-7-21)16-24(29(37)39)23-17-22(40-2)18-25(41-3)27(23)31/h4,16-19,21H,1,5-15H2,2-3H3,(H,32,33,34)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287001
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-22(38)36-12-10-35(11-13-36)8-7-9-37-26-18(16-32-28(34-26)33-17-29(2,3)40)14-19(27(37)39)23-24(30)20(41-4)15-21(42-5)25(23)31/h6,14-16,40H,1,7-13,17H2,2-5H3,(H,32,33,34)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287002
PNG
(8-((1-((4-acryloylpiperazin-1-yl)methyl)cyclopropy...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CC3(CN4CCN(CC4)C(=O)C=C)CC3)c2n1
Show InChI InChI=1S/C28H33ClN6O4/c1-5-23(36)34-10-8-33(9-11-34)16-28(6-7-28)17-35-25-18(15-31-27(30-2)32-25)12-21(26(35)37)20-13-19(38-3)14-22(39-4)24(20)29/h5,12-15H,1,6-11,16-17H2,2-4H3,(H,30,31,32)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286984
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287077
PNG
((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H](C)CO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C28H34Cl2N6O5/c1-5-22(38)35-11-9-34(10-12-35)7-6-8-36-26-18(15-31-28(33-26)32-17(2)16-37)13-19(27(36)39)23-24(29)20(40-3)14-21(41-4)25(23)30/h5,13-15,17,37H,1,6-12,16H2,2-4H3,(H,31,32,33)/t17-/m0/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286391
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC(C)C)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C28H34Cl2N6O4/c1-6-22(37)35-12-10-34(11-13-35)8-7-9-36-26-18(16-31-28(33-26)32-17(2)3)14-19(27(36)38)23-24(29)20(39-4)15-21(40-5)25(23)30/h6,14-17H,1,7-13H2,2-5H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287032
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCCN3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C31H40ClN7O5/c1-4-27(40)38-12-10-36(11-13-38)7-5-8-39-29-22(21-34-31(35-29)33-6-9-37-14-16-44-17-15-37)18-25(30(39)41)24-19-23(42-2)20-26(43-3)28(24)32/h4,18-21H,1,5-17H2,2-3H3,(H,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287039
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-amino-6-(...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C25H28Cl2N6O4/c1-4-19(34)32-10-8-31(9-11-32)6-5-7-33-23-15(14-29-25(28)30-23)12-16(24(33)35)20-21(26)17(36-2)13-18(37-3)22(20)27/h4,12-14H,1,5-11H2,2-3H3,(H2,28,29,30)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287061
PNG
((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m0/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287534
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCCN3CCOCC3)nc2n(CCOC2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H36Cl2N6O6/c1-4-24(39)37-17-20(18-37)44-13-10-38-28-19(16-34-30(35-28)33-6-5-7-36-8-11-43-12-9-36)14-21(29(38)40)25-26(31)22(41-2)15-23(42-3)27(25)32/h4,14-16,20H,1,5-13,17-18H2,2-3H3,(H,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287545
PNG
(1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)cc2n(CCOC2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H35Cl2N5O6/c1-4-26(38)36-17-20(18-36)43-12-9-37-22-14-25(33-5-6-35-7-10-42-11-8-35)34-16-19(22)13-21(30(37)39)27-28(31)23(40-2)15-24(41-3)29(27)32/h4,13-16,20H,1,5-12,17-18H2,2-3H3,(H,33,34)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286987
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287559
PNG
(8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287067
PNG
(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C25H28Cl2N6O4/c1-6-19(34)32-12-15(13-32)31(3)7-8-33-23-14(11-29-25(28-2)30-23)9-16(24(33)35)20-21(26)17(36-4)10-18(37-5)22(20)27/h6,9-11,15H,1,7-8,12-13H2,2-5H3,(H,28,29,30)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286381
PNG
(8-(2-((1-acryloylpiperidin-3-yl)oxy)ethyl)-6-(2,6-...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCCN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H29Cl2N5O5/c1-5-20(34)32-8-6-7-16(14-32)38-10-9-33-24-15(13-30-26(29-2)31-24)11-17(25(33)35)21-22(27)18(36-3)12-19(37-4)23(21)28/h5,11-13,16H,1,6-10,14H2,2-4H3,(H,29,30,31)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287519
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES CCN1CCN(CCCNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1
Show InChI InChI=1S/C32H41Cl2N7O5/c1-5-26(42)40-19-22(20-40)46-15-14-41-30-21(16-23(31(41)43)27-28(33)24(44-3)17-25(45-4)29(27)34)18-36-32(37-30)35-8-7-9-39-12-10-38(6-2)11-13-39/h5,16-18,22H,1,6-15,19-20H2,2-4H3,(H,35,36,37)
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n/an/a 3.60n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287030
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)nc2n(CCOC2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H34Cl2N6O6/c1-4-23(38)36-16-19(17-36)43-12-9-37-27-18(15-33-29(34-27)32-5-6-35-7-10-42-11-8-35)13-20(28(37)39)24-25(30)21(40-2)14-22(41-3)26(24)31/h4,13-15,19H,1,5-12,16-17H2,2-3H3,(H,32,33,34)
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n/an/a 3.60n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287038
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(F)F)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C27H30Cl2F2N6O4/c1-4-21(38)36-10-8-35(9-11-36)6-5-7-37-25-16(14-32-27(34-25)33-15-20(30)31)12-17(26(37)39)22-23(28)18(40-2)13-19(41-3)24(22)29/h4,12-14,20H,1,5-11,15H2,2-3H3,(H,32,33,34)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287006
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C31H38Cl2N6O5/c1-4-25(40)38-12-10-37(11-13-38)8-5-9-39-29-21(19-35-31(36-29)34-18-20-6-14-44-15-7-20)16-22(30(39)41)26-27(32)23(42-2)17-24(43-3)28(26)33/h4,16-17,19-20H,1,5-15,18H2,2-3H3,(H,34,35,36)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286992
PNG
(8-(2-((1-acryloylpiperidin-4-yl)oxy)ethyl)-6-(2,6-...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H31Cl2N5O5/c1-5-21(35)33-9-7-17(8-10-33)39-12-11-34-25-16(15-31-27(32-25)30-6-2)13-18(26(34)36)22-23(28)19(37-3)14-20(38-4)24(22)29/h5,13-15,17H,1,6-12H2,2-4H3,(H,30,31,32)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286997
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccn3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H31Cl2N7O4/c1-4-24(40)38-14-12-37(13-15-38)10-7-11-39-28-19(18-34-30(36-28)35-23-8-5-6-9-33-23)16-20(29(39)41)25-26(31)21(42-2)17-22(43-3)27(25)32/h4-6,8-9,16-18H,1,7,10-15H2,2-3H3,(H,33,34,35,36)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287044
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCOC(C)C)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H38Cl2N6O5/c1-6-24(39)37-13-11-36(12-14-37)9-7-10-38-28-20(18-34-30(35-28)33-8-15-43-19(2)3)16-21(29(38)40)25-26(31)22(41-4)17-23(42-5)27(25)32/h6,16-19H,1,7-15H2,2-5H3,(H,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287003
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(F)F)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C27H31ClF2N6O4/c1-4-23(37)35-10-8-34(9-11-35)6-5-7-36-25-17(15-31-27(33-25)32-16-22(29)30)12-20(26(36)38)19-13-18(39-2)14-21(40-3)24(19)28/h4,12-15,22H,1,5-11,16H2,2-3H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286383
PNG
(8-(3-((2R,6S)-4-acryloyl-2,6-dimethylpiperazin-1-y...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCCN3[C@@H](C)CN(C[C@H]3C)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H35ClN6O4/c1-7-24(36)33-15-17(2)34(18(3)16-33)9-8-10-35-26-19(14-31-28(30-4)32-26)11-22(27(35)37)21-12-20(38-5)13-23(39-6)25(21)29/h7,11-14,17-18H,1,8-10,15-16H2,2-6H3,(H,30,31,32)/t17-,18+
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287528
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES CCN1CCN(CCNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1
Show InChI InChI=1S/C31H39Cl2N7O5/c1-5-25(41)39-18-21(19-39)45-14-13-40-29-20(17-35-31(36-29)34-7-8-38-11-9-37(6-2)10-12-38)15-22(30(40)42)26-27(32)23(43-3)16-24(44-4)28(26)33/h5,15-17,21H,1,6-14,18-19H2,2-4H3,(H,34,35,36)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287037
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2-chl...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C24H26ClN5O5/c1-5-20(31)29-12-16(13-29)35-7-6-30-22-14(11-27-24(26-2)28-22)8-18(23(30)32)17-9-15(33-3)10-19(34-4)21(17)25/h5,8-11,16H,1,6-7,12-13H2,2-4H3,(H,26,27,28)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287041
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H34Cl2N6O5/c1-5-22(37)35-12-10-34(11-13-35)8-6-9-36-26-18(17-32-28(33-26)31-7-14-39-2)15-19(27(36)38)23-24(29)20(40-3)16-21(41-4)25(23)30/h5,15-17H,1,6-14H2,2-4H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287514
PNG
((R)-8-((1-(1-acryloylazetidin-3-yl)pyrrolidin-2-yl...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@H]3CCCN3C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H30Cl2N6O4/c1-5-21(36)33-12-17(13-33)34-8-6-7-16(34)14-35-25-15(11-31-27(30-2)32-25)9-18(26(35)37)22-23(28)19(38-3)10-20(39-4)24(22)29/h5,9-11,16-17H,1,6-8,12-14H2,2-4H3,(H,30,31,32)/t16-/m1/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287512
PNG
((R)¿N-(1-(2-(6-(2,6-dichloro-3,5-dimethoxyphenyl)-...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN3CCC[C@H](C3)NC(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)31-16-7-6-8-33(14-16)9-10-34-24-15(13-30-26(29-2)32-24)11-17(25(34)36)21-22(27)18(37-3)12-19(38-4)23(21)28/h5,11-13,16H,1,6-10,14H2,2-4H3,(H,31,35)(H,29,30,32)/t16-/m1/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286975
PNG
(8-(3-((3S,5R)-4-acryloyl-3,5-dimethylpiperazin-1-y...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3C[C@H](C)N([C@H](C)C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H34Cl2N6O4/c1-7-22(37)36-16(2)14-34(15-17(36)3)9-8-10-35-26-18(13-32-28(31-4)33-26)11-19(27(35)38)23-24(29)20(39-5)12-21(40-6)25(23)30/h7,11-13,16-17H,1,8-10,14-15H2,2-6H3,(H,31,32,33)/t16-,17+
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287069
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CCOCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C29H36Cl2N6O5/c1-5-23(38)36-13-11-35(12-14-36)9-7-10-37-27-19(18-33-29(34-27)32-8-15-42-6-2)16-20(28(37)39)24-25(30)21(40-3)17-22(41-4)26(24)31/h5,16-18H,1,6-15H2,2-4H3,(H,32,33,34)
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n/an/a 4.70n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287513
PNG
(8-(2-((1-acryloyl-3-methylazetidin-3-yl)oxy)ethyl)...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3(C)CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C25H27Cl2N5O5/c1-6-18(33)31-12-25(2,13-31)37-8-7-32-22-14(11-29-24(28-3)30-22)9-15(23(32)34)19-20(26)16(35-4)10-17(36-5)21(19)27/h6,9-11H,1,7-8,12-13H2,2-5H3,(H,28,29,30)
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n/an/a 4.80n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287058
PNG
((R)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES COC[C@@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-23(38)36-12-10-35(11-13-36)8-7-9-37-27-19(16-32-29(34-27)33-18(2)17-40-3)14-20(28(37)39)24-25(30)21(41-4)15-22(42-5)26(24)31/h6,14-16,18H,1,7-13,17H2,2-5H3,(H,32,33,34)/t18-/m1/s1
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n/an/a 4.90n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287517
PNG
((S)-8-((1-(1-acryloylazetidin-3-yl)pyrrolidin-2-yl...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@@H]3CCCN3C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H30Cl2N6O4/c1-5-21(36)33-12-17(13-33)34-8-6-7-16(34)14-35-25-15(11-31-27(30-2)32-25)9-18(26(35)37)22-23(28)19(38-3)10-20(39-4)24(22)29/h5,9-11,16-17H,1,6-8,12-14H2,2-4H3,(H,30,31,32)/t16-/m0/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286982
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC#C)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C28H30Cl2N6O4/c1-5-8-31-28-32-17-18-15-19(23-24(29)20(39-3)16-21(40-4)25(23)30)27(38)36(26(18)33-28)10-7-9-34-11-13-35(14-12-34)22(37)6-2/h1,6,15-17H,2,7-14H2,3-4H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287555
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C31H40Cl2N6O5/c1-6-25(40)38-18-21(19-38)44-14-13-39-29-20(17-35-31(36-29)34-11-9-10-12-37(7-2)8-3)15-22(30(39)41)26-27(32)23(42-4)16-24(43-5)28(26)33/h6,15-17,21H,1,7-14,18-19H2,2-5H3,(H,34,35,36)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287158
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@H]3CC[C@H](O)CC3)nc2n(CCOC2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H33Cl2N5O6/c1-4-23(38)35-14-19(15-35)42-10-9-36-27-16(13-32-29(34-27)33-17-5-7-18(37)8-6-17)11-20(28(36)39)24-25(30)21(40-2)12-22(41-3)26(24)31/h4,11-13,17-19,37H,1,5-10,14-15H2,2-3H3,(H,32,33,34)/t17-,18-
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287015
PNG
((R)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H34Cl2N6O5/c1-4-23(38)36-11-9-35(10-12-36)7-5-8-37-27-18(16-32-29(34-27)33-19-6-13-42-17-19)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-16,19H,1,5-13,17H2,2-3H3,(H,32,33,34)/t19-/m1/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287548
PNG
((S)-1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2...)
Show SMILES COC[C@H](C)Nc1cc2n(CCOC3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H32Cl2N4O6/c1-6-24(35)33-13-18(14-33)40-8-7-34-20-10-23(32-16(2)15-37-3)31-12-17(20)9-19(28(34)36)25-26(29)21(38-4)11-22(39-5)27(25)30/h6,9-12,16,18H,1,7-8,13-15H2,2-5H3,(H,31,32)/t16-/m0/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287042
PNG
(N-(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC(C)=O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C27H30Cl2N6O5/c1-5-21(37)34-11-9-33(10-12-34)7-6-8-35-25-17(15-30-27(32-25)31-16(2)36)13-18(26(35)38)22-23(28)19(39-3)14-20(40-4)24(22)29/h5,13-15H,1,6-12H2,2-4H3,(H,30,31,32,36)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287065
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C31H39ClN6O5/c1-4-27(39)37-12-10-36(11-13-37)8-5-9-38-29-22(20-34-31(35-29)33-19-21-6-14-43-15-7-21)16-25(30(38)40)24-17-23(41-2)18-26(42-3)28(24)32/h4,16-18,20-21H,1,5-15,19H2,2-3H3,(H,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287539
PNG
((S)-1-(3-(4-acryloylpiperazin-1-yl)propyl)-3-(2,6-...)
Show SMILES COC[C@H](C)Nc1cc2n(CCCN3CCN(CC3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C30H37Cl2N5O5/c1-6-26(38)36-12-10-35(11-13-36)8-7-9-37-22-15-25(34-19(2)18-40-3)33-17-20(22)14-21(30(37)39)27-28(31)23(41-4)16-24(42-5)29(27)32/h6,14-17,19H,1,7-13,18H2,2-5H3,(H,33,34)/t19-/m0/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287531
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES CCN1CCC(CNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1
Show InChI InChI=1S/C31H38Cl2N6O5/c1-5-25(40)38-17-21(18-38)44-12-11-39-29-20(16-35-31(36-29)34-15-19-7-9-37(6-2)10-8-19)13-22(30(39)41)26-27(32)23(42-3)14-24(43-4)28(26)33/h5,13-14,16,19,21H,1,6-12,15,17-18H2,2-4H3,(H,34,35,36)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287049
PNG
((R)-8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2...)
Show SMILES COC[C@@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H31Cl2N5O6/c1-6-21(35)33-12-17(13-33)40-8-7-34-25-16(11-30-27(32-25)31-15(2)14-37-3)9-18(26(34)36)22-23(28)19(38-4)10-20(39-5)24(22)29/h6,9-11,15,17H,1,7-8,12-14H2,2-5H3,(H,30,31,32)/t15-/m1/s1
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287045
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COCCOCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C30H38Cl2N6O6/c1-5-24(39)37-12-10-36(11-13-37)8-6-9-38-28-20(19-34-30(35-28)33-7-14-44-16-15-41-2)17-21(29(38)40)25-26(31)22(42-3)18-23(43-4)27(25)32/h5,17-19H,1,6-16H2,2-4H3,(H,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287558
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCCN(C)C)nc2n(CCOC2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C28H34Cl2N6O5/c1-6-22(37)35-15-18(16-35)41-11-10-36-26-17(14-32-28(33-26)31-8-7-9-34(2)3)12-19(27(36)38)23-24(29)20(39-4)13-21(40-5)25(23)30/h6,12-14,18H,1,7-11,15-16H2,2-5H3,(H,31,32,33)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287000
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(Nc3ccccn3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H32ClN7O4/c1-4-26(39)37-14-12-36(13-15-37)10-7-11-38-28-20(19-33-30(35-28)34-25-8-5-6-9-32-25)16-23(29(38)40)22-17-21(41-2)18-24(42-3)27(22)31/h4-6,8-9,16-19H,1,7,10-15H2,2-3H3,(H,32,33,34,35)
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Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287013
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC3CCCO3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H37ClN6O5/c1-4-26(38)36-12-10-35(11-13-36)8-6-9-37-28-20(18-32-30(34-28)33-19-21-7-5-14-42-21)15-24(29(37)39)23-16-22(40-2)17-25(41-3)27(23)31/h4,15-18,21H,1,5-14,19H2,2-3H3,(H,32,33,34)
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n/an/a 8n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287510
PNG
(US10294223, Cpd No. 88 | US9567334, Example 88 | U...)
Show SMILES COC(=O)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C25H25Cl2N5O7/c1-5-18(33)31-11-14(12-31)39-7-6-32-22-13(10-28-24(29-22)30-25(35)38-4)8-15(23(32)34)19-20(26)16(36-2)9-17(37-3)21(19)27/h5,8-10,14H,1,6-7,11-12H2,2-4H3,(H,28,29,30,35)
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n/an/a 8n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287019
PNG
((R)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287035
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCCN3CCCC3=O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C32H39Cl2N7O5/c1-4-25(42)40-16-14-38(15-17-40)10-7-13-41-30-21(20-36-32(37-30)35-9-6-12-39-11-5-8-26(39)43)18-22(31(41)44)27-28(33)23(45-2)19-24(46-3)29(27)34/h4,18-20H,1,5-17H2,2-3H3,(H,35,36,37)
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n/an/a 8.30n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287079
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)-2-methylpropyl...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CC(C)(C)OC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30ClN5O5/c1-7-21(33)31-12-17(13-31)37-26(2,3)14-32-23-15(11-29-25(28-4)30-23)8-19(24(32)34)18-9-16(35-5)10-20(36-6)22(18)27/h7-11,17H,1,12-14H2,2-6H3,(H,28,29,30)
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n/an/a 8.30n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287027
PNG
((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H34Cl2N6O5/c1-4-23(38)36-11-9-35(10-12-36)7-5-8-37-27-18(16-32-29(34-27)33-19-6-13-42-17-19)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-16,19H,1,5-13,17H2,2-3H3,(H,32,33,34)/t19-/m0/s1
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n/an/a 8.60n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286989
PNG
(8-(2-((1-acryloylpiperidin-4-yl)oxy)ethyl)-6-(2,6-...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(C)(C)O)nc2n(CCOC2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H35Cl2N5O6/c1-6-22(37)35-9-7-18(8-10-35)42-12-11-36-26-17(15-32-28(34-26)33-16-29(2,3)39)13-19(27(36)38)23-24(30)20(40-4)14-21(41-5)25(23)31/h6,13-15,18,39H,1,7-12,16H2,2-5H3,(H,32,33,34)
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n/an/a 8.80n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287043
PNG
((S)-8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2...)
Show SMILES COC[C@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H31Cl2N5O6/c1-6-21(35)33-12-17(13-33)40-8-7-34-25-16(11-30-27(32-25)31-15(2)14-37-3)9-18(26(34)36)22-23(28)19(38-4)10-20(39-5)24(22)29/h6,9-11,15,17H,1,7-8,12-14H2,2-5H3,(H,30,31,32)/t15-/m0/s1
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n/an/a 9.5n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286399
PNG
(8-(3-((3S,5R)-4-acryloyl-3,5-dimethylpiperazin-1-y...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCCN3C[C@H](C)N([C@H](C)C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H35ClN6O4/c1-7-24(36)35-17(2)15-33(16-18(35)3)9-8-10-34-26-19(14-31-28(30-4)32-26)11-22(27(34)37)21-12-20(38-5)13-23(39-6)25(21)29/h7,11-14,17-18H,1,8-10,15-16H2,2-6H3,(H,30,31,32)/t17-,18+
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n/an/a 10.6n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287081
PNG
((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES CCOC[C@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C30H38Cl2N6O5/c1-6-24(39)37-13-11-36(12-14-37)9-8-10-38-28-20(17-33-30(35-28)34-19(3)18-43-7-2)15-21(29(38)40)25-26(31)22(41-4)16-23(42-5)27(25)32/h6,15-17,19H,1,7-14,18H2,2-5H3,(H,33,34,35)/t19-/m0/s1
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n/an/a 10.7n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287046
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCN(C)CC3)nc2n(CCOC2CN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H37Cl2N7O5/c1-5-24(40)38-17-20(18-38)44-13-12-39-28-19(16-34-30(35-28)33-6-7-37-10-8-36(2)9-11-37)14-21(29(39)41)25-26(31)22(42-3)15-23(43-4)27(25)32/h5,14-16,20H,1,6-13,17-18H2,2-4H3,(H,33,34,35)
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n/an/a 12.7n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287022
PNG
((8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dic...)
Show SMILES COCC(COC)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C30H38Cl2N6O6/c1-6-24(39)37-12-10-36(11-13-37)8-7-9-38-28-19(16-33-30(35-28)34-20(17-41-2)18-42-3)14-21(29(38)40)25-26(31)22(43-4)15-23(44-5)27(25)32/h6,14-16,20H,1,7-13,17-18H2,2-5H3,(H,33,34,35)
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n/an/a 12.8n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287026
PNG
((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...)
Show SMILES COC[C@H](C)Nc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C29H37ClN6O5/c1-6-25(37)35-12-10-34(11-13-35)8-7-9-36-27-20(17-31-29(33-27)32-19(2)18-39-3)14-23(28(36)38)22-15-21(40-4)16-24(41-5)26(22)30/h6,14-17,19H,1,7-13,18H2,2-5H3,(H,31,32,33)/t19-/m0/s1
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n/an/a 14.2n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287011
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(F)(F)F)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C27H29Cl2F3N6O4/c1-4-20(39)37-10-8-36(9-11-37)6-5-7-38-24-16(14-33-26(35-24)34-15-27(30,31)32)12-17(25(38)40)21-22(28)18(41-2)13-19(42-3)23(21)29/h4,12-14H,1,5-11,15H2,2-3H3,(H,33,34,35)
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n/an/a 16.1n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286367
PNG
(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2-chloro-...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C25H29ClN6O4/c1-5-21(33)31-9-6-30(7-10-31)8-11-32-23-16(15-28-25(27-2)29-23)12-19(24(32)34)18-13-17(35-3)14-20(36-4)22(18)26/h5,12-15H,1,6-11H2,2-4H3,(H,27,28,29)
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n/an/a 16.2n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286996
PNG
(8-(2-((1-acryloylpiperidin-4-yl)oxy)ethyl)-2-((cyc...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCOC2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H33Cl2N5O5/c1-4-23(37)35-9-7-19(8-10-35)41-12-11-36-27-18(16-33-29(34-27)32-15-17-5-6-17)13-20(28(36)38)24-25(30)21(39-2)14-22(40-3)26(24)31/h4,13-14,16-17,19H,1,5-12,15H2,2-3H3,(H,32,33,34)
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n/an/a 16.3n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287073
PNG
(US10294223, Cpd No. 82 | US9567334, Example 82 | U...)
Show SMILES COC(=O)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H30Cl2N6O6/c1-5-20(36)34-11-9-33(10-12-34)7-6-8-35-24-16(15-30-26(31-24)32-27(38)41-4)13-17(25(35)37)21-22(28)18(39-2)14-19(40-3)23(21)29/h5,13-15H,1,6-12H2,2-4H3,(H,30,31,32,38)
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n/an/a 18n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286980
PNG
(8-(3-((2R,6S)-4-acryloyl-2,6-dimethylpiperazin-1-y...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3[C@@H](C)CN(C[C@H]3C)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H34Cl2N6O4/c1-7-22(37)34-14-16(2)35(17(3)15-34)9-8-10-36-26-18(13-32-28(31-4)33-26)11-19(27(36)38)23-24(29)20(39-5)12-21(40-6)25(23)30/h7,11-13,16-17H,1,8-10,14-15H2,2-6H3,(H,31,32,33)/t16-,17+
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n/an/a 18.7n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287082
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)-2-methylpropyl...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CC(C)(C)OC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H29Cl2N5O5/c1-7-19(34)32-11-15(12-32)38-26(2,3)13-33-23-14(10-30-25(29-4)31-23)8-16(24(33)35)20-21(27)17(36-5)9-18(37-6)22(20)28/h7-10,15H,1,11-13H2,2-6H3,(H,29,30,31)
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n/an/a 19n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287523
PNG
((E)-8-(2-((1-(but-2-enoyl)azetidin-3-yl)(methyl)am...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)\C=C\C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-7-20(35)33-13-16(14-33)32(3)8-9-34-24-15(12-30-26(29-2)31-24)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6-7,10-12,16H,8-9,13-14H2,1-5H3,(H,29,30,31)/b7-6+
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n/an/a 22.7n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286400
PNG
(N-(1-(2-(6-(2-chloro-3,5-dimethoxyphenyl)-2-(methy...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCN3CCC(CC3)NC(=O)C=C)c2n1
Show InChI InChI=1S/C26H31ClN6O4/c1-5-22(34)30-17-6-8-32(9-7-17)10-11-33-24-16(15-29-26(28-2)31-24)12-20(25(33)35)19-13-18(36-3)14-21(37-4)23(19)27/h5,12-15,17H,1,6-11H2,2-4H3,(H,30,34)(H,28,29,31)
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n/an/a 25n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287085
PNG
((E)-8-(3-(4-(but-2-enoyl)piperazin-1-yl)propyl)-6-...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)\C=C\C)c2n1
Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-7-21(36)34-12-10-33(11-13-34)8-6-9-35-25-17(16-31-27(30-2)32-25)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,7,14-16H,6,8-13H2,1-4H3,(H,30,31,32)/b7-5+
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n/an/a 27.4n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286991
PNG
(8-(3-(4-acryloylpiperazin-1-yl)-2,2-dimethylpropyl...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CC(C)(C)CN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C28H35ClN6O4/c1-7-23(36)34-10-8-33(9-11-34)16-28(2,3)17-35-25-18(15-31-27(30-4)32-25)12-21(26(35)37)20-13-19(38-5)14-22(39-6)24(20)29/h7,12-15H,1,8-11,16-17H2,2-6H3,(H,30,31,32)
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n/an/a 33.8n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286981
PNG
(8-(2-((3aR,6aS)-5-acryloylhexahydropyrrolo[3,4-c]p...)
Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCN3C[C@H]4CN(C[C@H]4C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H31ClN6O4/c1-5-23(35)33-14-17-12-32(13-18(17)15-33)6-7-34-25-16(11-30-27(29-2)31-25)8-21(26(34)36)20-9-19(37-3)10-22(38-4)24(20)28/h5,8-11,17-18H,1,6-7,12-15H2,2-4H3,(H,29,30,31)/t17-,18+
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n/an/a 169n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM287055
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC3COC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C28H32Cl2N6O5/c1-4-22(37)35-10-8-34(9-11-35)6-5-7-36-26-17(14-31-28(33-26)32-18-15-41-16-18)12-19(27(36)38)23-24(29)20(39-2)13-21(40-3)25(23)30/h4,12-14,18H,1,5-11,15-16H2,2-3H3,(H,31,32,33)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Principia Biopharma Inc

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9815834 (2017)


BindingDB Entry DOI: 10.7270/Q2B85B83
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%