BindingDB logo
myBDB logout

Patent code US9815842

Compile Data Set for Download or QSAR
Found 127 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355969
PNG
((S)-1-(5-chloro-6- (difluoromethoxy) pyridin-3-yl)...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(OC(F)F)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14Cl2F2N6O3/c1-7(28-2)13-10(6-21-12-4-11(18)25-26(12)13)24-16(27)23-8-3-9(17)14(22-5-8)29-15(19)20/h3-7,15H,1-2H3,(H2,23,24,27)/t7-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355967
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC1(CCCO1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O3/c1-33-11-20(3-2-6-34-20)17-14(10-23-16-8-15(22)29-30(16)17)28-19(32)27-12-7-13(21)18(24-9-12)31-25-4-5-26-31/h4-5,7-10H,2-3,6,11H2,1H3,(H2,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355885
PNG
((S)-1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chlo...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(OC)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H16Cl2N6O3/c1-8(26-2)14-11(7-19-13-5-12(18)23-24(13)14)22-16(25)21-9-4-10(17)15(27-3)20-6-9/h4-8H,1-3H3,(H2,21,22,25)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355892
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CC1(CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15Cl2N9O/c1-18(2-3-18)15-12(9-21-14-7-13(20)27-28(14)15)26-17(30)25-10-6-11(19)16(22-8-10)29-23-4-5-24-29/h4-9H,2-3H2,1H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355970
PNG
((S)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromet...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(F)nn12
Show InChI InChI=1S/C18H15F4N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355886
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H15Cl2N9O2/c1-9(30-2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355971
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(F)nn12
Show InChI InChI=1S/C17H15ClFN9O2/c1-9(30-2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355980
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Cc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(n2n1)C1(C)CCCO1
Show InChI InChI=1S/C20H20ClN9O2/c1-12-8-16-22-11-15(17(29(16)28-12)20(2)4-3-7-32-20)27-19(31)26-13-9-14(21)18(23-10-13)30-24-5-6-25-30/h5-6,8-11H,3-4,7H2,1-2H3,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169049
PNG
(CHEMBL3806155 | US9815842, Example 1)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15ClF3N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355889
PNG
((S)-methyl 3-chloro- 5-(3-(2-chloro-7-(1- methoxye...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cc(Cl)cc(c2)C(=O)OC)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N5O4/c1-9(28-2)16-13(8-21-15-7-14(20)24-25(15)16)23-18(27)22-12-5-10(17(26)29-3)4-11(19)6-12/h4-9H,1-3H3,(H2,22,23,27)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355950
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O2/c1-10(2)17(32-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355897
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H15Cl2N9O/c1-9(2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355911
PNG
(1-(7-(sec-butyl)-2- chloropyrazolo[1,5- a]pyrimidi...)
Show SMILES CCC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O/c1-3-10(2)16-13(9-21-15-7-14(20)27-28(15)16)26-18(30)25-11-6-12(19)17(22-8-11)29-23-4-5-24-29/h4-10H,3H2,1-2H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355987
PNG
((R)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromet...)
Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H17ClF3N9O2/c1-10(9-34-2)16-13(8-24-15-6-14(20)30-31(15)16)29-18(33)28-11-5-12(19(21,22)23)17(25-7-11)32-26-3-4-27-32/h3-8,10H,9H2,1-2H3,(H2,28,29,33)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355896
PNG
(1-(3-chloro-4-(2H- 1,2,3-triazol-2- yl)phenyl)-3-(...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H16Cl2N8O/c1-10(2)17-13(9-21-16-8-15(20)26-27(16)17)25-18(29)24-11-3-4-14(12(19)7-11)28-22-5-6-23-28/h3-10H,1-2H3,(H2,24,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355948
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Cc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(n2n1)C1(C)CC1
Show InChI InChI=1S/C19H18ClN9O/c1-11-7-15-21-10-14(16(28(15)27-11)19(2)3-4-19)26-18(30)25-12-8-13(20)17(22-9-12)29-23-5-6-24-29/h5-10H,3-4H2,1-2H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355894
PNG
(1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7...)
Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl
Show InChI InChI=1S/C16H16Cl2N6O2/c1-8(2)14-11(7-19-13-5-12(18)23-24(13)14)22-16(25)21-9-4-10(17)15(26-3)20-6-9/h4-8H,1-3H3,(H2,21,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355895
PNG
(1-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(c2)C#N)-n2cnc(C)n2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H18ClN9O/c1-11(2)19-15(9-23-18-7-17(21)28-30(18)19)26-20(31)25-14-4-5-16(13(6-14)8-22)29-10-24-12(3)27-29/h4-7,9-11H,1-3H3,(H2,25,26,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355906
PNG
(1-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(Cl)c(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15Cl3N8O/c1-9(2)16-13(8-22-15-7-14(21)27-28(15)16)26-18(30)25-10-5-11(19)17(12(20)6-10)29-23-3-4-24-29/h3-9H,1-2H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355965
PNG
((S)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H16ClF2N9O2/c1-9(32-2)15-12(8-22-14-6-13(19)28-29(14)15)27-18(31)26-10-5-11(16(20)21)17(23-7-10)30-24-3-4-25-30/h3-9,16H,1-2H3,(H2,26,27,31)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355973
PNG
((S)-1-(5-chloro-6- (difluoromethoxy)py- ridin-3-yl...)
Show SMILES COCCO[C@@H](C)c1c(NC(=O)Nc2cnc(OC(F)F)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18Cl2F2N6O4/c1-9(31-4-3-30-2)15-12(8-23-14-6-13(20)27-28(14)15)26-18(29)25-10-5-11(19)16(24-7-10)32-17(21)22/h5-9,17H,3-4H2,1-2H3,(H2,25,26,29)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355915
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES COCCO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O3/c1-11(33-6-5-32-2)17-14(10-22-16-8-15(21)28-29(16)17)27-19(31)26-12-7-13(20)18(23-9-12)30-24-3-4-25-30/h3-4,7-11H,5-6H2,1-2H3,(H2,26,27,31)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355925
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COC(c1ccccc1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C22H17Cl2N9O2/c1-35-20(13-5-3-2-4-6-13)19-16(12-25-18-10-17(24)31-32(18)19)30-22(34)29-14-9-15(23)21(26-11-14)33-27-7-8-28-33/h2-12,20H,1H3,(H2,29,30,34)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355890
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COC(C)(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O2/c1-18(2,31-3)15-12(9-21-14-7-13(20)27-28(14)15)26-17(30)25-10-6-11(19)16(22-8-10)29-23-4-5-24-29/h4-9H,1-3H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355921
PNG
((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355978
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES C[C@H](OC[C@H]1CCOC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C21H21Cl2N9O3/c1-12(35-11-13-2-5-34-10-13)19-16(9-24-18-7-17(23)30-31(18)19)29-21(33)28-14-6-15(22)20(25-8-14)32-26-3-4-27-32/h3-4,6-9,12-13H,2,5,10-11H2,1H3,(H2,28,29,33)/t12-,13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355898
PNG
(1-(5-chloro-6-(4- methyl-2H-1,2,3- triazol-2-yl)py...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2ncc(C)n2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O/c1-9(2)16-13(8-21-15-5-14(20)27-28(15)16)25-18(30)24-11-4-12(19)17(22-7-11)29-23-6-10(3)26-29/h4-9H,1-3H3,(H2,24,25,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355929
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COc1ccccc1-c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C21H15Cl2N9O2/c1-34-16-5-3-2-4-13(16)19-15(11-24-18-9-17(23)30-31(18)19)29-21(33)28-12-8-14(22)20(25-10-12)32-26-6-7-27-32/h2-11H,1H3,(H2,28,29,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169052
PNG
(CHEMBL3806235 | US9815842, Example 54)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
Show InChI InChI=1S/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355920
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES COC[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355878
PNG
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14ClF3N6O2/c1-8(28-2)14-10(7-22-13-6-12(17)25-26(13)14)24-15(27)23-9-3-4-21-11(5-9)16(18,19)20/h3-8H,1-2H3,(H2,21,23,24,27)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355910
PNG
(1-(7-(tert-butyl)-2- chloropyrazolo[1,5- a]pyrimid...)
Show SMILES CC(C)(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O/c1-18(2,3)15-12(9-21-14-7-13(20)27-28(14)15)26-17(30)25-10-6-11(19)16(22-8-10)29-23-4-5-24-29/h4-9H,1-3H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355899
PNG
(1-(4-(2- aminopyrimidin-4- yl)-3-chlorophenyl)- 3-...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-c2ccnc(N)n2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H17Cl2N9O/c1-9(2)17-13(8-24-15-6-14(21)29-30(15)17)28-19(31)26-10-5-11(20)16(25-7-10)12-3-4-23-18(22)27-12/h3-9H,1-2H3,(H2,22,23,27)(H2,26,28,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355881
PNG
((R)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES CO[C@H](C(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O2/c1-10(2)17(32-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355951
PNG
((S)-1-(2-chloro-7-(1- methoxy-2- methylpropyl)pyra...)
Show SMILES CO[C@@H](C(C)C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18ClF3N6O2/c1-9(2)16(30-3)15-11(8-24-14-7-13(19)27-28(14)15)26-17(29)25-10-4-5-23-12(6-10)18(20,21)22/h4-9,16H,1-3H3,(H2,23,25,26,29)/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355974
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CO[C@H](C)[C@H](OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O3/c1-10(32-2)17(33-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t10-,17+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
PDB
UniChem
PDB
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355900
PNG
(1-(5-chloro-1- methyl-6-oxo-2-(1H- pyrazol-1-yl)-1...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(Cl)c(=O)n(C)c2-n2cccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18Cl2N8O2/c1-10(2)16-13(9-22-15-8-14(21)26-29(15)16)25-19(31)24-12-7-11(20)18(30)27(3)17(12)28-6-4-5-23-28/h4-10H,1-3H3,(H2,24,25,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355947
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(C)nn12
Show InChI InChI=1S/C18H18ClN9O2/c1-10-6-15-20-9-14(16(11(2)30-3)27(15)26-10)25-18(29)24-12-7-13(19)17(21-8-12)28-22-4-5-23-28/h4-9,11H,1-3H3,(H2,24,25,29)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355979
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES C[C@H](OC[C@@H]1CCOC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C21H21Cl2N9O3/c1-12(35-11-13-2-5-34-10-13)19-16(9-24-18-7-17(23)30-31(18)19)29-21(33)28-14-6-15(22)20(25-8-14)32-26-3-4-27-32/h3-4,6-9,12-13H,2,5,10-11H2,1H3,(H2,28,29,33)/t12-,13+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355957
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC(C)(OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O3/c1-19(33-3,10-32-2)16-13(9-22-15-7-14(21)28-29(15)16)27-18(31)26-11-6-12(20)17(23-8-11)30-24-4-5-25-30/h4-9H,10H2,1-3H3,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355891
PNG
(1-(2-chloro-7-(2- methoxypropan-2- yl)pyrazolo[1,5...)
Show SMILES COC(C)(C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O2/c1-16(2,29-3)14-10(8-23-13-7-12(18)26-27(13)14)25-15(28)24-9-4-5-22-11(6-9)17(19,20)21/h4-8H,1-3H3,(H2,22,24,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355901
PNG
(1-(5-chloro-6- ethoxypyridin-3-yl)- 3-(2-chloro-7-...)
Show SMILES CCOc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl
Show InChI InChI=1S/C17H18Cl2N6O2/c1-4-27-16-11(18)5-10(7-21-16)22-17(26)23-12-8-20-14-6-13(19)24-25(14)15(12)9(2)3/h5-9H,4H2,1-3H3,(H2,22,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355902
PNG
(1-(5-bromopyridin-3- yl)-3-(2-chloro-7- isopropylp...)
Show SMILES CC(C)c1c(NC(=O)Nc2cncc(Br)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C15H14BrClN6O/c1-8(2)14-11(7-19-13-4-12(17)22-23(13)14)21-15(24)20-10-3-9(16)5-18-6-10/h3-8H,1-2H3,(H2,20,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355914
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCC3)n2n1
Show InChI InChI=1S/C18H15Cl2N9O/c19-12-6-11(8-22-17(12)29-23-4-5-24-29)25-18(30)26-13-9-21-15-7-14(20)27-28(15)16(13)10-2-1-3-10/h4-10H,1-3H2,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355931
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CC1(CCOCC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O2/c1-20(2-6-33-7-3-20)17-14(11-23-16-9-15(22)29-30(16)17)28-19(32)27-12-8-13(21)18(24-10-12)31-25-4-5-26-31/h4-5,8-11H,2-3,6-7H2,1H3,(H2,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355932
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC(OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O3/c1-31-9-13(32-2)16-12(8-21-15-6-14(20)27-28(15)16)26-18(30)25-10-5-11(19)17(22-7-10)29-23-3-4-24-29/h3-8,13H,9H2,1-2H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355977
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES C[C@H](OC1CCOC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O3/c1-11(34-13-2-5-33-10-13)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-12-6-14(21)19(24-8-12)31-25-3-4-26-31/h3-4,6-9,11,13H,2,5,10H2,1H3,(H2,27,28,32)/t11-,13?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM356002
PNG
((R)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES COC[C@H](OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O3/c1-31-9-13(32-2)16-12(8-21-15-6-14(20)27-28(15)16)26-18(30)25-10-5-11(19)17(22-7-10)29-23-3-4-24-29/h3-8,13H,9H2,1-2H3,(H2,25,26,30)/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355961
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CO[C@H](C)CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H21Cl2N9O3/c1-11(33-3)10-34-12(2)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-13-6-14(21)19(24-8-13)31-25-4-5-26-31/h4-9,11-12H,10H2,1-3H3,(H2,27,28,32)/t11-,12+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355928
PNG
(1-(4-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CC3)n2n1
Show InChI InChI=1S/C17H13Cl2N9O/c18-11-5-10(7-21-16(11)28-22-3-4-23-28)24-17(29)25-12-8-20-14-6-13(19)26-27(14)15(12)9-1-2-9/h3-9H,1-2H2,(H2,24,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355880
PNG
((R)-1-(6-(2H-1,2,3-triazol-2-yl)-5-(trifluoromethy...)
Show SMILES CO[C@H](C(C)C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19ClF3N9O2/c1-10(2)17(35-3)16-13(9-25-15-7-14(21)31-32(15)16)30-19(34)29-11-6-12(20(22,23)24)18(26-8-11)33-27-4-5-28-33/h4-10,17H,1-3H3,(H2,29,30,34)/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169051
PNG
(CHEMBL3805576 | US9815842, Example 27)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19ClF3N7O3S/c1-10(2)16-13(9-24-15-7-14(20)28-30(15)16)27-18(31)26-11-6-12(19(21,22)23)17(25-8-11)29-4-3-5-34(29,32)33/h6-10H,3-5H2,1-2H3,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.00600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355927
PNG
(1-(2-chloro-7-(1- (methoxymethyl)cyclo- butyl)pyra...)
Show SMILES COCC1(CCC1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18ClF3N6O2/c1-31-10-18(4-2-5-18)16-12(9-25-15-8-14(20)28-29(15)16)27-17(30)26-11-3-6-24-13(7-11)19(21,22)23/h3,6-9H,2,4-5,10H2,1H3,(H2,24,26,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355953
PNG
(1-(2-chloro-7-(1- (methoxymethyl)cyclo- propyl)pyr...)
Show SMILES COCC1(CC1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H16ClF3N6O2/c1-30-9-17(3-4-17)15-11(8-24-14-7-13(19)27-28(14)15)26-16(29)25-10-2-5-23-12(6-10)18(20,21)22/h2,5-8H,3-4,9H2,1H3,(H2,23,25,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355952
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC1(CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H17Cl2N9O2/c1-32-10-19(2-3-19)16-13(9-22-15-7-14(21)28-29(15)16)27-18(31)26-11-6-12(20)17(23-8-11)30-24-4-5-25-30/h4-9H,2-3,10H2,1H3,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355916
PNG
((S)-1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chlo...)
Show SMILES COCCO[C@@H](C)c1c(NC(=O)Nc2cnc(OC)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H20Cl2N6O4/c1-10(30-5-4-28-2)16-13(9-21-15-7-14(20)25-26(15)16)24-18(27)23-11-6-12(19)17(29-3)22-8-11/h6-10H,4-5H2,1-3H3,(H2,23,24,27)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355990
PNG
((S)-1-(2-chloro-7-(1-hydroxyethyl)pyrazolo[1,5-a]p...)
Show SMILES C[C@H](OCc1ccccc1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C22H18ClF3N6O2/c1-13(34-12-14-5-3-2-4-6-14)20-16(11-28-19-10-18(23)31-32(19)20)30-21(33)29-15-7-8-27-17(9-15)22(24,25)26/h2-11,13H,12H2,1H3,(H2,27,29,30,33)/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355963
PNG
(1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7...)
Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCC(C)O2)cc1Cl
Show InChI InChI=1S/C18H18Cl2N6O3/c1-9-3-4-13(29-9)16-12(8-21-15-6-14(20)25-26(15)16)24-18(27)23-10-5-11(19)17(28-2)22-7-10/h5-9,13H,3-4H2,1-2H3,(H2,23,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355884
PNG
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cncc(c2)C#N)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14ClN7O2/c1-9(26-2)15-12(8-20-14-4-13(17)23-24(14)15)22-16(25)21-11-3-10(5-18)6-19-7-11/h3-4,6-9H,1-2H3,(H2,21,22,25)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355883
PNG
((S)-1-(2-fluoro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(F)nn12
Show InChI InChI=1S/C16H14F4N6O2/c1-8(28-2)14-10(7-22-13-6-12(17)25-26(13)14)24-15(27)23-9-3-4-21-11(5-9)16(18,19)20/h3-8H,1-2H3,(H2,21,23,24,27)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355982
PNG
(1-(2-chloro-7-(2- (methoxymethyl)tetra- hydrofuran...)
Show SMILES COCC1(CCCO1)c1c(NC(=O)Nc2cncc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18ClF3N6O3/c1-31-10-18(3-2-4-32-18)16-13(9-25-15-6-14(20)28-29(15)16)27-17(30)26-12-5-11(7-24-8-12)19(21,22)23/h5-9H,2-4,10H2,1H3,(H2,26,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355984
PNG
(1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromethyl)...)
Show SMILES COCC(OC)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H17ClF3N9O3/c1-34-9-13(35-2)16-12(8-24-15-6-14(20)30-31(15)16)29-18(33)28-10-5-11(19(21,22)23)17(25-7-10)32-26-3-4-27-32/h3-8,13H,9H2,1-2H3,(H2,28,29,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355998
PNG
((S)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES C[C@H](N(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18Cl2N10O/c1-10(28(2)3)16-13(9-21-15-7-14(20)27-29(15)16)26-18(31)25-11-6-12(19)17(22-8-11)30-23-4-5-24-30/h4-10H,1-3H3,(H2,25,26,31)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355993
PNG
(1-(4-(4-(aminomethyl)-1H-pyrazol-1-yl)-3-chlorophe...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2cc(CNC(=O)OC(C)(C)C)cn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C25H28Cl2N8O3/c1-14(2)22-18(12-28-21-9-20(27)33-35(21)22)32-23(36)31-16-6-7-19(17(26)8-16)34-13-15(11-30-34)10-29-24(37)38-25(3,4)5/h6-9,11-14H,10H2,1-5H3,(H,29,37)(H2,31,32,36)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355939
PNG
(1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromethyl)...)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2-c2ccco2)cnc1-n1nccn1
Show InChI InChI=1S/C19H11ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h1-9H,(H2,28,29,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM356000
PNG
((S)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES CN[C@@H](C(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H20Cl2N10O/c1-10(2)16(22-3)17-13(9-23-15-7-14(21)29-30(15)17)28-19(32)27-11-6-12(20)18(24-8-11)31-25-4-5-26-31/h4-10,16,22H,1-3H3,(H2,27,28,32)/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM356001
PNG
(1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)...)
Show SMILES CN1CCOCC1c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18Cl2N10O2/c1-29-4-5-33-10-14(29)17-13(9-22-16-7-15(21)28-30(16)17)27-19(32)26-11-6-12(20)18(23-8-11)31-24-2-3-25-31/h2-3,6-9,14H,4-5,10H2,1H3,(H2,26,27,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355904
PNG
(1-(3-chloro-4-(3- (hydroxymethyl)-5- methyl-1H-pyr...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nc(CO)cc2C)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20Cl2N8O2/c1-10(2)18-15(8-23-17-6-16(22)28-30(17)18)26-20(32)25-12-5-14(21)19(24-7-12)29-11(3)4-13(9-31)27-29/h4-8,10,31H,9H2,1-3H3,(H2,25,26,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355912
PNG
(1-(2-chloro-7-(2- methyltetrahydrofuran- 2-yl)pyra...)
Show SMILES CC1(CCCO1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H16ClF3N6O2/c1-17(4-2-6-30-17)15-11(9-24-14-8-13(19)27-28(14)15)26-16(29)25-10-3-5-23-12(7-10)18(20,21)22/h3,5,7-9H,2,4,6H2,1H3,(H2,23,25,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355941
PNG
((R)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromet...)
Show SMILES C[C@@H](OCc1ccccc1)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C24H19ClF3N9O2/c1-14(39-13-15-5-3-2-4-6-15)21-18(12-29-20-10-19(25)35-36(20)21)34-23(38)33-16-9-17(24(26,27)28)22(30-11-16)37-31-7-8-32-37/h2-12,14H,13H2,1H3,(H2,33,34,38)/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355968
PNG
((S)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H15ClF2N6O2/c1-8(27-2)14-11(7-21-13-6-12(17)24-25(13)14)23-16(26)22-9-3-4-20-10(5-9)15(18)19/h3-8,15H,1-2H3,(H2,20,22,23,26)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355934
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCOCC3)n2n1
Show InChI InChI=1S/C19H17Cl2N9O2/c20-13-7-12(9-23-18(13)30-24-3-4-25-30)26-19(31)27-14-10-22-16-8-15(21)28-29(16)17(14)11-1-5-32-6-2-11/h3-4,7-11H,1-2,5-6H2,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355986
PNG
((S)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trilfuoromet...)
Show SMILES COC[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H17ClF3N9O2/c1-10(9-34-2)16-13(8-24-15-6-14(20)30-31(15)16)29-18(33)28-11-5-12(19(21,22)23)17(25-7-11)32-26-3-4-27-32/h3-8,10H,9H2,1-2H3,(H2,28,29,33)/t10-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355919
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3COCCO3)n2n1
Show InChI InChI=1S/C18H15Cl2N9O3/c19-11-5-10(7-22-17(11)29-23-1-2-24-29)25-18(30)26-12-8-21-15-6-14(20)27-28(15)16(12)13-9-31-3-4-32-13/h1-2,5-8,13H,3-4,9H2,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355996
PNG
(2-(3-(2-chloro-7-isopropylpyrazolo[1,5-a]pyrimidin...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(cc[n+]2[O-])C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14ClF3N6O2/c1-8(2)14-10(7-21-12-6-11(17)24-26(12)14)22-15(27)23-13-5-9(16(18,19)20)3-4-25(13)28/h3-8H,1-2H3,(H2,22,23,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM356003
PNG
((S)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES COC[C@@H](OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O3/c1-31-9-13(32-2)16-12(8-21-15-6-14(20)27-28(15)16)26-18(30)25-10-5-11(19)17(22-7-10)29-23-3-4-24-29/h3-8,13H,9H2,1-2H3,(H2,25,26,30)/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355882
PNG
((S)-1-(7-(1-methoxyethyl)-2-methylpyrazolo[1,5-a]p...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(C)nn12
Show InChI InChI=1S/C17H17F3N6O2/c1-9-6-14-22-8-12(15(10(2)28-3)26(14)25-9)24-16(27)23-11-4-5-21-13(7-11)17(18,19)20/h4-8,10H,1-3H3,(H2,21,23,24,27)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355972
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-tirazol-2- yl)pyridin...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(nn12)C#N
Show InChI InChI=1S/C18H15ClN10O2/c1-10(31-2)16-14(9-21-15-6-11(7-20)27-28(15)16)26-18(30)25-12-5-13(19)17(22-8-12)29-23-3-4-24-29/h3-6,8-10H,1-2H3,(H2,25,26,30)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355913
PNG
((R)-1-(2-chloro-7-(1- methoxy-2- methylpropyl)pyra...)
Show SMILES CO[C@H](C(C)C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18ClF3N6O2/c1-9(2)16(30-3)15-11(8-24-14-7-13(19)27-28(14)15)26-17(29)25-10-4-5-23-12(6-10)18(20,21)22/h4-9,16H,1-3H3,(H2,23,25,26,29)/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355893
PNG
(1-(2-chloro-7-(1- methylcyclopropyl) pyrazolo[1,5-...)
Show SMILES CC1(CC1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H14ClF3N6O/c1-16(3-4-16)14-10(8-23-13-7-12(18)26-27(13)14)25-15(28)24-9-2-5-22-11(6-9)17(19,20)21/h2,5-8H,3-4H2,1H3,(H2,22,24,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355941
PNG
((R)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromet...)
Show SMILES C[C@@H](OCc1ccccc1)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C24H19ClF3N9O2/c1-14(39-13-15-5-3-2-4-6-15)21-18(12-29-20-10-19(25)35-36(20)21)34-23(38)33-16-9-17(24(26,27)28)22(30-11-16)37-31-7-8-32-37/h2-12,14H,13H2,1H3,(H2,33,34,38)/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355981
PNG
((S)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C#N)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14ClN7O2/c1-9(26-2)15-12(8-20-14-6-13(17)23-24(14)15)22-16(25)21-10-3-4-19-11(5-10)7-18/h3-6,8-9H,1-2H3,(H2,19,21,22,25)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355995
PNG
((S)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES C[C@H](N(C)C(=O)OC(C)(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C22H24Cl2N10O3/c1-12(32(5)21(36)37-22(2,3)4)18-15(11-25-17-9-16(24)31-33(17)18)30-20(35)29-13-8-14(23)19(26-10-13)34-27-6-7-28-34/h6-12H,1-5H3,(H2,29,30,35)/t12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355949
PNG
(1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-methyl-7...)
Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(C)nn3c2C2(C)CC2)cc1Cl
Show InChI InChI=1S/C18H19ClN6O2/c1-10-6-14-20-9-13(15(25(14)24-10)18(2)4-5-18)23-17(26)22-11-7-12(19)16(27-3)21-8-11/h6-9H,4-5H2,1-3H3,(H2,22,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355940
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCCC(OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O3/c1-32-6-3-14(33-2)17-13(10-22-16-8-15(21)28-29(16)17)27-19(31)26-11-7-12(20)18(23-9-11)30-24-4-5-25-30/h4-5,7-10,14H,3,6H2,1-2H3,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355922
PNG
((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CO[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H15Cl2N9O2/c1-9(30-2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)/t9-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355983
PNG
(1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromethyl)...)
Show SMILES CN(C)C1(CC1)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H18ClF3N10O/c1-32(2)19(3-4-19)16-13(10-25-15-8-14(21)31-33(15)16)30-18(35)29-11-7-12(20(22,23)24)17(26-9-11)34-27-5-6-28-34/h5-10H,3-4H2,1-2H3,(H2,29,30,35)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355964
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CN(C)C1(CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18Cl2N10O/c1-29(2)19(3-4-19)16-13(10-22-15-8-14(21)28-30(15)16)27-18(32)26-11-7-12(20)17(23-9-11)31-24-5-6-25-31/h5-10H,3-4H2,1-2H3,(H2,26,27,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355879
PNG
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cc(cn(C)c2=O)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O3/c1-8(30-3)14-11(6-22-13-5-12(18)25-27(13)14)24-16(29)23-10-4-9(17(19,20)21)7-26(2)15(10)28/h4-8H,1-3H3,(H2,23,24,29)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355888
PNG
((S)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2ccnc(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C15H14Cl2N6O2/c1-8(25-2)14-10(7-19-13-6-12(17)22-23(13)14)21-15(24)20-9-3-4-18-11(16)5-9/h3-8H,1-2H3,(H2,18,20,21,24)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355907
PNG
(1-(5-chloro-2- oxoindolin-7-yl)-3-(2- chloro-7- is...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(Cl)cc3CC(=O)Nc23)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H16Cl2N6O2/c1-8(2)17-12(7-21-14-6-13(20)25-26(14)17)23-18(28)22-11-5-10(19)3-9-4-15(27)24-16(9)11/h3,5-8H,4H2,1-2H3,(H,24,27)(H2,22,23,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355988
PNG
(1-(5-(2H-1,2,3-triazol-2-yl)-2-(trifluoromethyl)py...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(ncc2-n2nccn2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15ClF3N9O/c1-9(2)16-11(7-24-15-6-14(19)29-30(15)16)28-17(32)27-10-5-13(18(20,21)22)23-8-12(10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,23,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0160n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355942
PNG
(US9815842, Example 66 | tert-butyl 2-(2- chloro-6-...)
Show SMILES CC(C)(C)OC(=O)C1CCOC(C1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C24H25Cl2N9O4/c1-24(2,3)39-22(36)13-4-7-38-17(8-13)20-16(12-27-19-10-18(26)33-34(19)20)32-23(37)31-14-9-15(25)21(28-11-14)35-29-5-6-30-35/h5-6,9-13,17H,4,7-8H2,1-3H3,(H2,31,32,37)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0180n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355933
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCOC3)n2n1
Show InChI InChI=1S/C18H15Cl2N9O2/c19-12-5-11(7-22-17(12)29-23-2-3-24-29)25-18(30)26-13-8-21-15-6-14(20)27-28(15)16(13)10-1-4-31-9-10/h2-3,5-8,10H,1,4,9H2,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355960
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES CN1CCCC[C@H]1c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20Cl2N10O/c1-30-7-3-2-4-15(30)18-14(11-23-17-9-16(22)29-31(17)18)28-20(33)27-12-8-13(21)19(24-10-12)32-25-5-6-26-32/h5-6,8-11,15H,2-4,7H2,1H3,(H2,27,28,33)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355908
PNG
(1-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(cn(C)c2=O)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O2/c1-8(2)14-11(6-22-13-5-12(18)25-27(13)14)24-16(29)23-10-4-9(17(19,20)21)7-26(3)15(10)28/h4-8H,1-3H3,(H2,23,24,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355937
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CC(C)OCc1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(2)31-9-14-13(8-21-16-6-15(20)27-28(14)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355935
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCc1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H13Cl2N9O2/c1-29-8-12-11(7-19-14-5-13(18)25-26(12)14)24-16(28)23-9-4-10(17)15(20-6-9)27-21-2-3-22-27/h2-7H,8H2,1H3,(H2,23,24,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355887
PNG
((S)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(OC)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18ClN9O3/c1-10(30-2)16-12(9-20-15-7-14(19)26-27(15)16)25-18(29)24-11-6-13(31-3)17(21-8-11)28-22-4-5-23-28/h4-10H,1-3H3,(H2,24,25,29)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355976
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES C[C@H](O[C@@H]1CCOC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O3/c1-11(34-13-2-5-33-10-13)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-12-6-14(21)19(24-8-12)31-25-3-4-26-31/h3-4,6-9,11,13H,2,5,10H2,1H3,(H2,27,28,32)/t11-,13+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355997
PNG
((R)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3...)
Show SMILES C[C@@H](N(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18Cl2N10O/c1-10(28(2)3)16-13(9-21-15-7-14(20)27-29(15)16)26-18(31)25-11-6-12(19)17(22-8-11)30-23-4-5-24-30/h4-10H,1-3H3,(H2,25,26,31)/t10-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355926
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC1(CCC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O2/c1-33-11-20(3-2-4-20)17-14(10-23-16-8-15(22)29-30(16)17)28-19(32)27-12-7-13(21)18(24-9-12)31-25-5-6-26-31/h5-10H,2-4,11H2,1H3,(H2,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355954
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES COCC1(CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(C)nn12
Show InChI InChI=1S/C20H20ClN9O2/c1-12-7-16-22-10-15(17(29(16)28-12)20(3-4-20)11-32-2)27-19(31)26-13-8-14(21)18(23-9-13)30-24-5-6-25-30/h5-10H,3-4,11H2,1-2H3,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0210n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355918
PNG
((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES COCCO[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O3/c1-11(33-6-5-32-2)17-14(10-22-16-8-15(21)28-29(16)17)27-19(31)26-12-7-13(20)18(23-9-12)30-24-3-4-25-30/h3-4,7-11H,5-6H2,1-2H3,(H2,26,27,31)/t11-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0210n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355975
PNG
((S)-1-(5-chloro-2-(2- (dimethylamino)eth- oxy)pyri...)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cc(Cl)cnc2OCCN(C)C)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H23Cl2N7O3/c1-11(30-4)17-14(10-22-16-8-15(21)26-28(16)17)25-19(29)24-13-7-12(20)9-23-18(13)31-6-5-27(2)3/h7-11H,5-6H2,1-4H3,(H2,24,25,29)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0210n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355917
PNG
((S)-1-(2-chloro-7-(1- (2- methoxyethoxy)ethyl) pyr...)
Show SMILES COCCO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H18ClF3N6O3/c1-10(31-6-5-30-2)16-12(9-24-15-8-14(19)27-28(15)16)26-17(29)25-11-3-4-23-13(7-11)18(20,21)22/h3-4,7-10H,5-6H2,1-2H3,(H2,23,25,26,29)/t10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0240n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355936
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(CC3CCOCC3)n2n1
Show InChI InChI=1S/C20H19Cl2N9O2/c21-14-8-13(10-24-19(14)31-25-3-4-26-31)27-20(32)28-15-11-23-18-9-17(22)29-30(18)16(15)7-12-1-5-33-6-2-12/h3-4,8-12H,1-2,5-7H2,(H2,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0260n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355994
PNG
(1-(6-(4-(aminomethyl)-1H-pyrazol-1-yl)-5-chloropyr...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2cc(CN)cn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19Cl2N9O/c1-10(2)17-14(8-23-16-4-15(21)28-30(16)17)27-19(31)26-12-3-13(20)18(24-7-12)29-9-11(5-22)6-25-29/h3-4,6-10H,5,22H2,1-2H3,(H2,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0280n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355923
PNG
((R)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C16H14ClF3N6O2/c1-8(28-2)14-10(7-22-13-6-12(17)25-26(13)14)24-15(27)23-9-3-4-21-11(5-9)16(18,19)20/h3-8H,1-2H3,(H2,21,23,24,27)/t8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0290n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355909
PNG
(1-(5-chloro-2-((1- methylpyrrolidin-3- yl)oxy)-6-(...)
Show SMILES CC(C)c1c(NC(=O)Nc2cc(Cl)c(nc2OC2CCN(C)C2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C22H24Cl2N10O2/c1-12(2)19-16(10-25-18-9-17(24)31-33(18)19)29-22(35)28-15-8-14(23)20(34-26-5-6-27-34)30-21(15)36-13-4-7-32(3)11-13/h5-6,8-10,12-13H,4,7,11H2,1-3H3,(H2,28,29,35)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355956
PNG
(1-(2-chloro-7-(2- (tetrahydro-2H- pyran-4-yl)propa...)
Show SMILES CC(C)(C1CCOCC1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C21H22ClF3N6O2/c1-20(2,12-4-7-33-8-5-12)18-14(11-27-17-10-16(22)30-31(17)18)29-19(32)28-13-3-6-26-15(9-13)21(23,24)25/h3,6,9-12H,4-5,7-8H2,1-2H3,(H2,26,28,29,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0340n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355943
PNG
(1-(7-(3- oxabicyclo[3.1.0]hex- an-6-yl)-2- chlorop...)
Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2C3COCC23)cc1Cl
Show InChI InChI=1S/C18H16Cl2N6O3/c1-28-17-11(19)2-8(4-22-17)23-18(27)24-12-5-21-14-3-13(20)25-26(14)16(12)15-9-6-29-7-10(9)15/h2-5,9-10,15H,6-7H2,1H3,(H2,23,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0350n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355944
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CC33CCOC3)n2n1
Show InChI InChI=1S/C20H17Cl2N9O2/c21-13-5-11(8-24-18(13)31-25-2-3-26-31)27-19(32)28-14-9-23-16-6-15(22)29-30(16)17(14)12-7-20(12)1-4-33-10-20/h2-3,5-6,8-9,12H,1,4,7,10H2,(H2,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0390n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355999
PNG
(1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N1CCOCC1c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C23H24Cl2N10O4/c1-23(2,3)39-22(37)33-6-7-38-12-16(33)19-15(11-26-18-9-17(25)32-34(18)19)31-21(36)30-13-8-14(24)20(27-10-13)35-28-4-5-29-35/h4-5,8-11,16H,6-7,12H2,1-3H3,(H2,30,31,36)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0410n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355938
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES Cc1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C15H11Cl2N9O/c1-8-11(7-18-13-5-12(17)24-25(8)13)23-15(27)22-9-4-10(16)14(19-6-9)26-20-2-3-21-26/h2-7H,1H3,(H2,22,23,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0420n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355924
PNG
((R)-1-(2-chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-...)
Show SMILES CO[C@H](C)c1c(NC(=O)Nc2cc(cn(C)c2=O)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O3/c1-8(30-3)14-11(6-22-13-5-12(18)25-27(13)14)24-16(29)23-10-4-9(17(19,20)21)7-26(2)15(10)28/h4-8H,1-3H3,(H2,23,24,29)/t8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0420n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355955
PNG
(1-(7-(1- (methoxymethyl)cyclo- propyl)-2- methylpy...)
Show SMILES COCC1(CC1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(C)nn12
Show InChI InChI=1S/C19H19F3N6O2/c1-11-7-15-24-9-13(16(28(15)27-11)18(4-5-18)10-30-2)26-17(29)25-12-3-6-23-14(8-12)19(20,21)22/h3,6-9H,4-5,10H2,1-2H3,(H2,23,25,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0450n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355985
PNG
(1-(2-chloro-7-(1,2- dimethoxyethyl)pyra- zolo[1,5-...)
Show SMILES COCC(OC)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O3/c1-29-8-11(30-2)15-10(7-23-14-6-13(18)26-27(14)15)25-16(28)24-9-3-4-22-12(5-9)17(19,20)21/h3-7,11H,8H2,1-2H3,(H2,22,24,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0530n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355959
PNG
(1-(5-chloro-6-(2h- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CN1CCOCC1Cc1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20Cl2N10O2/c1-30-4-5-34-11-13(30)7-16-15(10-23-18-8-17(22)29-31(16)18)28-20(33)27-12-6-14(21)19(24-9-12)32-25-2-3-26-32/h2-3,6,8-10,13H,4-5,7,11H2,1H3,(H2,27,28,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0550n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355992
PNG
(1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)...)
Show SMILES CN1CCOC(C1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18Cl2N10O2/c1-29-4-5-33-14(10-29)17-13(9-22-16-7-15(21)28-30(16)17)27-19(32)26-11-6-12(20)18(23-8-11)31-24-2-3-25-31/h2-3,6-9,14H,4-5,10H2,1H3,(H2,26,27,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0710n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355991
PNG
(1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N1CCOC(C1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C23H24Cl2N10O4/c1-23(2,3)39-22(37)33-6-7-38-16(12-33)19-15(11-26-18-9-17(25)32-34(18)19)31-21(36)30-13-8-14(24)20(27-10-13)35-28-4-5-29-35/h4-5,8-11,16H,6-7,12H2,1-3H3,(H2,30,31,36)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0760n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355962
PNG
(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Show SMILES CN1CCN=C1c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15Cl2N11O/c1-29-5-4-21-17(29)15-12(9-22-14-7-13(20)28-30(14)15)27-18(32)26-10-6-11(19)16(23-8-10)31-24-2-3-25-31/h2-3,6-9H,4-5H2,1H3,(H2,26,27,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355945
PNG
(1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7...)
Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2-c2ccncc2)cc1Cl
Show InChI InChI=1S/C18H13Cl2N7O2/c1-29-17-12(19)6-11(8-23-17)24-18(28)25-13-9-22-15-7-14(20)26-27(15)16(13)10-2-4-21-5-3-10/h2-9H,1H3,(H2,24,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0860n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355966
PNG
(1-(2-chloro-7- (methoxy(tetrahydro- 2H-pyran-4- yl...)
Show SMILES COC(C1CCOCC1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20ClF3N6O3/c1-32-18(11-3-6-33-7-4-11)17-13(10-26-16-9-15(21)29-30(16)17)28-19(31)27-12-2-5-25-14(8-12)20(22,23)24/h2,5,8-11,18H,3-4,6-7H2,1H3,(H2,25,27,28,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0970n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355958
PNG
((S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Show SMILES C[C@H](OCCN(C)C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H22Cl2N10O2/c1-12(34-7-6-30(2)3)18-15(11-23-17-9-16(22)29-31(17)18)28-20(33)27-13-8-14(21)19(24-10-13)32-25-4-5-26-32/h4-5,8-12H,6-7H2,1-3H3,(H2,27,28,33)/t12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.122n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355946
PNG
(2-chloro-6-(3-(5- chloro-6-(2H-1,2,3- triazol-2-yl...)
Show SMILES CN(C)C(=O)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H14Cl2N10O2/c1-27(2)16(30)14-11(8-20-13-6-12(19)26-28(13)14)25-17(31)24-9-5-10(18)15(21-7-9)29-22-3-4-23-29/h3-8H,1-2H3,(H2,24,25,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.123n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM355905
PNG
(1-(5-chloro-6-(1- methyl-1H-pyrazol- 5-yl)pyridin-...)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(-c3ccnn3C)c(Cl)c2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H18Cl2N8O/c1-10(2)18-13(9-22-16-7-15(21)27-29(16)18)26-19(30)25-11-6-12(20)17(23-8-11)14-4-5-24-28(14)3/h4-10H,1-3H3,(H2,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.370n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...


US Patent US9815842 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%