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Patent code US9815850

Compile Data Set for Download or QSAR

Found 266 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50233233
PNG
(CHEMBL4088627 | US10604535, Example 5 | US9815850,...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)s2)C1=O
Show InChI InChI=1S/C21H19N3O3S/c1-24-17-9-5-6-10-18(17)27-13-16(21(24)26)23-19(25)20-22-12-15(28-20)11-14-7-3-2-4-8-14/h2-10,12,16H,11,13H2,1H3,(H,23,25)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356264
PNG
(US10604535, Example 30 | US9815850, Compound 30 | ...)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2ccnc12)c1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C23H20N4O2/c28-23(20-15-18(29-26-20)14-16-6-2-1-3-7-16)25-19-11-10-17-8-4-5-9-21(17)27-13-12-24-22(19)27/h1-9,12-13,15,19H,10-11,14H2,(H,25,28)/t19-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356285
PNG
(US10604535, Example 56 | US9815850, Compound 56 | ...)
Show SMILES CN1c2cccc(C#N)c2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356286
PNG
(US10604535, Example 57 | US9815850, Compound 57 | ...)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2NC1=O
Show InChI InChI=1S/C19H16FN5O3/c20-13-10-25(9-12-5-2-1-3-6-12)24-16(13)19(27)22-14-11-28-15-7-4-8-21-17(15)23-18(14)26/h1-8,10,14H,9,11H2,(H,22,27)(H,21,23,26)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356287
PNG
(US10604535, Example 58 | US9815850, Compound 58 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc(s2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C22H20N4O3S/c1-26-16-9-5-6-10-17(16)29-13-15(20(26)28)23-18(27)19-24-25-21(30-19)22(11-12-22)14-7-3-2-4-8-14/h2-10,15H,11-13H2,1H3,(H,23,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356301
PNG
(US10604535, Example 69A | US9815850, Compound 69A ...)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2cnnc12)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356314
PNG
(US10604535, Example 78 | US9815850, Compound 78 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc([nH]2)C2(CC2)c2ccccc2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356326
PNG
(US10604535, Example 86 | US9815850, Compound 86 | ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)s2)C1=O
Show InChI InChI=1S/C20H18N4O3S/c1-24-17-16(8-5-9-21-17)27-12-15(20(24)26)23-18(25)19-22-11-14(28-19)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,25)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356361
PNG
(US10604535, Example 110B | US9815850, Compound 110...)
Show SMILES O=C(N[C@H]1[C@H]2C[C@H]2c2cccnc2NC1=O)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356379
PNG
(US10604535, Example 122 | US9815850, Compound 122 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cc(Cc2ccccc2)no1
Show InChI InChI=1S/C21H20N4O4/c1-13-18(21(27)25(2)19-16(28-13)9-6-10-22-19)23-20(26)17-12-15(24-29-17)11-14-7-4-3-5-8-14/h3-10,12-13,18H,11H2,1-2H3,(H,23,26)/t13-,18+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356393
PNG
(US10604535, Example 133 | US9815850, Compound 133 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3F)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-18-16(7-4-8-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-5-2-3-6-13(12)21/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356397
PNG
(US10604535, Example 137 | US9815850, Compound 137 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cncc(F)c3)cc2F)C1=O
Show InChI InChI=1S/C19H16F2N6O3/c1-26-17-15(3-2-4-23-17)30-10-14(19(26)29)24-18(28)16-13(21)9-27(25-16)8-11-5-12(20)7-22-6-11/h2-7,9,14H,8,10H2,1H3,(H,24,28)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356402
PNG
(US10604535, Example 141B | US9815850, Compound 141...)
Show SMILES O=C(N[C@H]1COc2cccnc2-n2ccnc12)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356417
PNG
(US9815850, Compound 153 | US9896458, No. 153)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3C#N)cc2F)C1=O
Show InChI InChI=1S/C21H17FN6O3/c1-27-19-17(7-4-8-24-19)31-12-16(21(27)30)25-20(29)18-15(22)11-28(26-18)10-14-6-3-2-5-13(14)9-23/h2-8,11,16H,10,12H2,1H3,(H,25,29)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356419
PNG
(US10604535, Example 154B | US9815850, Compound 154...)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2-n2ccnc12
Show InChI InChI=1S/C21H17FN6O2/c22-15-12-27(11-14-5-2-1-3-6-14)26-18(15)21(29)25-16-13-30-17-7-4-8-23-20(17)28-10-9-24-19(16)28/h1-10,12,16H,11,13H2,(H,25,29)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356422
PNG
(US10604535, Example 156B | US9815850, Compound 156...)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nn(Cc3ccc(F)cc3)cc2F)C1=O
Show InChI InChI=1S/C22H19F2N5O2/c1-28-20-14(3-2-8-25-20)15-9-16(15)18(22(28)31)26-21(30)19-17(24)11-29(27-19)10-12-4-6-13(23)7-5-12/h2-8,11,15-16,18H,9-10H2,1H3,(H,26,30)/t15-,16-,18-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356425
PNG
(US10604535, Example 158 | US9815850, Compound 158 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(C#N)n(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H18N6O3/c1-26-19-18(8-5-9-23-19)30-13-17(21(26)29)24-20(28)16-10-15(11-22)27(25-16)12-14-6-3-2-4-7-14/h2-10,17H,12-13H2,1H3,(H,24,28)/t17-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356431
PNG
(US10604535, Example 163 | US9815850, Compound 163 ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc(Cc3cccc(c3)C#N)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356441
PNG
(US10604535, Example 172 | US9815850, Compound 172 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncn(Cc2cccc(c2)C#N)n1
Show InChI InChI=1S/C21H19N7O3/c1-13-17(21(30)27(2)19-16(31-13)7-4-8-23-19)25-20(29)18-24-12-28(26-18)11-15-6-3-5-14(9-15)10-22/h3-9,12-13,17H,11H2,1-2H3,(H,25,29)/t13-,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356394
PNG
(US10604535, Example 174 | US9815850, Compound 134 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C20H19N5O4/c1-12-16(20(27)25(2)17-14(28-12)9-6-10-21-17)22-18(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356457
PNG
(US10604535, Example 182B | US9815850, Compound 182...)
Show SMILES CN1c2nccnc2CC[C@H](NC(=O)c2nn(Cc3cccnc3C)cc2F)C1=O
Show InChI InChI=1S/C20H20FN7O2/c1-12-13(4-3-7-22-12)10-28-11-14(21)17(26-28)19(29)25-16-6-5-15-18(24-9-8-23-15)27(2)20(16)30/h3-4,7-9,11,16H,5-6,10H2,1-2H3,(H,25,29)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356460
PNG
(US10604535, Example 184 | US9815850, Compound 184 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cnn(C)c3)cc2F)C1=O
Show InChI InChI=1S/C18H18FN7O3/c1-24-7-11(6-21-24)8-26-9-12(19)15(23-26)17(27)22-13-10-29-14-4-3-5-20-16(14)25(2)18(13)28/h3-7,9,13H,8,10H2,1-2H3,(H,22,27)/t13-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356479
PNG
(US10604535, Example 214 | US9815850, Compound 214 ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccc(F)cn3)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-16-4-2-3-5-17(16)30-11-15(20(26)29)24-19(28)18-14(22)10-27(25-18)9-13-7-6-12(21)8-23-13/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356482
PNG
(US10604535, Example 217 | US9815850, Compound 217 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)s1
Show InChI InChI=1S/C20H19N5O3S/c1-12-16(20(27)25(2)17-14(28-12)9-6-10-21-17)22-18(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356484
PNG
(US10604535, Example 219 | US9815850, Compound 219 ...)
Show SMILES CN1c2ncccc2CC[C@H](NC(=O)c2ncc(Cc3cccc(c3)C#N)s2)C1=O
Show InChI InChI=1S/C22H19N5O2S/c1-27-19-16(6-3-9-24-19)7-8-18(22(27)29)26-20(28)21-25-13-17(30-21)11-14-4-2-5-15(10-14)12-23/h2-6,9-10,13,18H,7-8,11H2,1H3,(H,26,28)/t18-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356487
PNG
(US10604535, Example 222 | US9815850, Compound 222 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1noc(Cc2ccccc2)n1
Show InChI InChI=1S/C20H19N5O4/c1-12-16(20(27)25(2)18-14(28-12)9-6-10-21-18)23-19(26)17-22-15(29-24-17)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,23,26)/t12-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356488
PNG
(US10604535, Example 223 | US9815850, Compound 223 ...)
Show SMILES CN1c2nccnc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccc(F)cc3)o2)C1=O
Show InChI InChI=1S/C20H17FN6O3/c1-27-17-15(22-6-7-23-17)12-9-13(12)16(20(27)29)24-18(28)19-26-25-14(30-19)8-10-2-4-11(21)5-3-10/h2-7,12-13,16H,8-9H2,1H3,(H,24,28)/t12-,13+,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356489
PNG
(US10604535, Example 224 | US9815850, Compound 224 ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ncccn3)cc2F)C1=O
Show InChI InChI=1S/C19H17FN6O3/c1-25-14-5-2-3-6-15(14)29-11-13(19(25)28)23-18(27)17-12(20)9-26(24-17)10-16-21-7-4-8-22-16/h2-9,13H,10-11H2,1H3,(H,23,27)/t13-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356233
PNG
(US10604535, Example 3 | US9815850, Compound 3 | US...)
Show SMILES CN1c2ccccc2C(=C)C[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C23H21N3O3/c1-15-12-20(23(28)26(2)21-11-7-6-10-18(15)21)24-22(27)19-14-17(29-25-19)13-16-8-4-3-5-9-16/h3-11,14,20H,1,12-13H2,2H3,(H,24,27)/t20-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356242
PNG
(US10604535, Example 10 | US9815850, Compound 10 | ...)
Show SMILES CN1c2ccccc2C(F)(F)CC(NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356249
PNG
(US10604535, Example 13 | US9815850, Compound 13 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc3[C@H](CCn3n2)c2ccccc2)C1=O
Show InChI InChI=1S/C23H22N4O3/c1-26-19-9-5-6-10-21(19)30-14-18(23(26)29)24-22(28)17-13-20-16(11-12-27(20)25-17)15-7-3-2-4-8-15/h2-10,13,16,18H,11-12,14H2,1H3,(H,24,28)/t16-,18+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356294
PNG
(US10604535, Example 64 | US9815850, Compound 64 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C21H19FN4O3/c1-25-17-9-5-6-10-18(17)29-13-16(21(25)28)23-20(27)19-15(22)12-26(24-19)11-14-7-3-2-4-8-14/h2-10,12,16H,11,13H2,1H3,(H,23,27)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356303
PNG
(US9815850, Compound 70A)
Show SMILES O=C(N[C@H]1COc2ccccc2-n2cnnc12)c1cc(Cc2ccccc2)[nH]n1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356320
PNG
(US10604535, Example 82A | US9815850, Compound 82A ...)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C22H20FN5O2/c1-27-20-14(8-5-9-24-20)15-10-16(15)18(22(27)30)25-21(29)19-17(23)12-28(26-19)11-13-6-3-2-4-7-13/h2-9,12,15-16,18H,10-11H2,1H3,(H,25,29)/t15-,16-,18-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356345
PNG
(US10604535, Example 101B | US9815850, Compound 101...)
Show SMILES CN1c2cnn(C)c2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356357
PNG
(US10604535, Example 108 | US9815850, Compound 108 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356358
PNG
(US10604535, Example 109A | US9815850, Compound 109...)
Show SMILES CN1c2cn(C)nc2CC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C20H21FN6O2/c1-25-12-17-15(23-25)8-9-16(20(29)26(17)2)22-19(28)18-14(21)11-27(24-18)10-13-6-4-3-5-7-13/h3-7,11-12,16H,8-10H2,1-2H3,(H,22,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356370
PNG
(US10604535, Example 117 | US9815850, Compound 117 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cc(Oc2ccccc2F)ccn1
Show InChI InChI=1S/C22H19FN4O4/c1-13-19(22(29)27(2)20-18(30-13)8-5-10-25-20)26-21(28)16-12-14(9-11-24-16)31-17-7-4-3-6-15(17)23/h3-13,19H,1-2H3,(H,26,28)/t13-,19+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356395
PNG
(US10604535, Example 135 | US9815850, Compound 135 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cccc(F)c3)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-18-16(6-3-7-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-4-2-5-13(21)8-12/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356412
PNG
(US10604535, Example 149 | US9815850, Compound 149 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(Oc3ccccc3F)cnn2)C1=O
Show InChI InChI=1S/C20H16FN5O4/c1-26-18-17(7-4-8-22-18)29-11-15(20(26)28)24-19(27)14-9-12(10-23-25-14)30-16-6-3-2-5-13(16)21/h2-10,15H,11H2,1H3,(H,24,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356413
PNG
(US10604535, Example 150 | US9815850, Compound 150 ...)
Show SMILES C[C@H]1Oc2cc(cnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)[nH]1)C#N
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356416
PNG
(US10604535, Example 152B | US9815850, Compound 152...)
Show SMILES CN1c2ncccc2CC[C@H](NC(=O)c2nn(Cc3cccc(c3)C#N)cc2F)C1=O
Show InChI InChI=1S/C22H19FN6O2/c1-28-20-16(6-3-9-25-20)7-8-18(22(28)31)26-21(30)19-17(23)13-29(27-19)12-15-5-2-4-14(10-15)11-24/h2-6,9-10,13,18H,7-8,12H2,1H3,(H,26,30)/t18-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356424
PNG
(US10604535, Example 157B | US9815850, Compound 157...)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccccc3)o2)C1=O
Show InChI InChI=1S/C21H19N5O3/c1-26-18-13(8-5-9-22-18)14-11-15(14)17(21(26)28)23-19(27)20-25-24-16(29-20)10-12-6-3-2-4-7-12/h2-9,14-15,17H,10-11H2,1H3,(H,23,27)/t14-,15-,17-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356430
PNG
(US10604535, Example 162 | US9815850, Compound 162 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3cc(F)cc(c3)C#N)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356312
PNG
(US10604535, Example 175 | US9815850, Compound 175 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C20H18FN5O3/c1-25-18-16(8-5-9-22-18)29-12-15(20(25)28)23-19(27)17-14(21)11-26(24-17)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356445
PNG
(US10604535, Example 176 | US9815850, Compound 176 ...)
Show SMILES Fc1cc(F)c2NC(=O)[C@@H](NC(=O)c3nnc(Cc4ccccc4)[nH]3)[C@@H]3C[C@@H]3c2c1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356480
PNG
(US10604535, Example 215 | US9815850, Compound 215 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2noc(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C19H17N5O4/c1-24-17-14(8-5-9-20-17)27-11-13(19(24)26)21-18(25)16-22-15(28-23-16)10-12-6-3-2-4-7-12/h2-9,13H,10-11H2,1H3,(H,21,25)/t13-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356246
PNG
(US10604535, Example 12A | US9815850, Compound 12 |...)
Show SMILES CN1c2ccccc2[C@@H](F)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356282
PNG
(US10604535, Example 54B | US9815850, Compound 54A ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%