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Patent code US9815850

Compile Data Set for Download or QSAR

Found 266 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50233233
PNG
(CHEMBL4088627 | US9815850, Compound 5)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)s2)C1=O
Show InChI InChI=1S/C21H19N3O3S/c1-24-17-9-5-6-10-18(17)27-13-16(21(24)26)23-19(25)20-22-12-15(28-20)11-14-7-3-2-4-8-14/h2-10,12,16H,11,13H2,1H3,(H,23,25)/t16-/m0/s1
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356264
PNG
(US9815850, Compound 30)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2ccnc12)c1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C23H20N4O2/c28-23(20-15-18(29-26-20)14-16-6-2-1-3-7-16)25-19-11-10-17-8-4-5-9-21(17)27-13-12-24-22(19)27/h1-9,12-13,15,19H,10-11,14H2,(H,25,28)/t19-/m0/s1
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356285
PNG
(US9815850, Compound 56)
Show SMILES CN1c2cccc(C#N)c2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1S/C21H18N6O3/c1-27-16-9-5-8-14(11-22)18(16)30-12-15(21(27)29)23-20(28)19-24-17(25-26-19)10-13-6-3-2-4-7-13/h2-9,15H,10,12H2,1H3,(H,23,28)(H,24,25,26)/t15-/m0/s1
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356286
PNG
(US9815850, Compound 57)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2NC1=O
Show InChI InChI=1S/C19H16FN5O3/c20-13-10-25(9-12-5-2-1-3-6-12)24-16(13)19(27)22-14-11-28-15-7-4-8-21-17(15)23-18(14)26/h1-8,10,14H,9,11H2,(H,22,27)(H,21,23,26)/t14-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356287
PNG
(US9815850, Compound 58)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc(s2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C22H20N4O3S/c1-26-16-9-5-6-10-17(16)29-13-15(20(26)28)23-18(27)19-24-25-21(30-19)22(11-12-22)14-7-3-2-4-8-14/h2-10,15H,11-13H2,1H3,(H,23,27)/t15-/m0/s1
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356301
PNG
(US9815850, Compound 69A)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2cnnc12)c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1S/C21H19N7O/c29-21(19-24-18(25-26-19)12-14-6-2-1-3-7-14)23-16-11-10-15-8-4-5-9-17(15)28-13-22-27-20(16)28/h1-9,13,16H,10-12H2,(H,23,29)(H,24,25,26)/t16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356314
PNG
(US9815850, Compound 78)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc([nH]2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C23H22N4O3/c1-27-17-9-5-6-10-18(17)30-14-16(22(27)29)25-21(28)20-24-13-19(26-20)23(11-12-23)15-7-3-2-4-8-15/h2-10,13,16H,11-12,14H2,1H3,(H,24,26)(H,25,28)/t16-/m0/s1
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356326
PNG
(US9815850, Compound 86)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)s2)C1=O
Show InChI InChI=1S/C20H18N4O3S/c1-24-17-16(8-5-9-21-17)27-12-15(20(24)26)23-18(25)19-22-11-14(28-19)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,25)/t15-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356361
PNG
(US9815850, Compound 110B)
Show SMILES O=C(N[C@H]1[C@H]2C[C@H]2c2cccnc2NC1=O)c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1S/C20H18N6O2/c27-19-16(14-10-13(14)12-7-4-8-21-17(12)24-19)23-20(28)18-22-15(25-26-18)9-11-5-2-1-3-6-11/h1-8,13-14,16H,9-10H2,(H,23,28)(H,21,24,27)(H,22,25,26)/t13-,14-,16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356379
PNG
(US9815850, Compound 122)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cc(Cc2ccccc2)no1
Show InChI InChI=1S/C21H20N4O4/c1-13-18(21(27)25(2)19-16(28-13)9-6-10-22-19)23-20(26)17-12-15(24-29-17)11-14-7-4-3-5-8-14/h3-10,12-13,18H,11H2,1-2H3,(H,23,26)/t13-,18+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356393
PNG
(US9815850, Compound 133)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3F)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-18-16(7-4-8-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-5-2-3-6-13(12)21/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356397
PNG
(US9815850, Compound 137)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cncc(F)c3)cc2F)C1=O
Show InChI InChI=1S/C19H16F2N6O3/c1-26-17-15(3-2-4-23-17)30-10-14(19(26)29)24-18(28)16-13(21)9-27(25-16)8-11-5-12(20)7-22-6-11/h2-7,9,14H,8,10H2,1H3,(H,24,28)/t14-/m0/s1
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356402
PNG
(US9815850, Compound 141B)
Show SMILES O=C(N[C@H]1COc2cccnc2-n2ccnc12)c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1S/C20H17N7O2/c28-20(17-24-16(25-26-17)11-13-5-2-1-3-6-13)23-14-12-29-15-7-4-8-21-19(15)27-10-9-22-18(14)27/h1-10,14H,11-12H2,(H,23,28)(H,24,25,26)/t14-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356417
PNG
(US9815850, Compound 153)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3C#N)cc2F)C1=O
Show InChI InChI=1S/C21H17FN6O3/c1-27-19-17(7-4-8-24-19)31-12-16(21(27)30)25-20(29)18-15(22)11-28(26-18)10-14-6-3-2-5-13(14)9-23/h2-8,11,16H,10,12H2,1H3,(H,25,29)/t16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356419
PNG
(US9815850, Compound 154B)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2-n2ccnc12
Show InChI InChI=1S/C21H17FN6O2/c22-15-12-27(11-14-5-2-1-3-6-14)26-18(15)21(29)25-16-13-30-17-7-4-8-23-20(17)28-10-9-24-19(16)28/h1-10,12,16H,11,13H2,(H,25,29)/t16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356422
PNG
(US9815850, Compound 156B)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nn(Cc3ccc(F)cc3)cc2F)C1=O
Show InChI InChI=1S/C22H19F2N5O2/c1-28-20-14(3-2-8-25-20)15-9-16(15)18(22(28)31)26-21(30)19-17(24)11-29(27-19)10-12-4-6-13(23)7-5-12/h2-8,11,15-16,18H,9-10H2,1H3,(H,26,30)/t15-,16-,18-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356425
PNG
(US9815850, Compound 158)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(C#N)n(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H18N6O3/c1-26-19-18(8-5-9-23-19)30-13-17(21(26)29)24-20(28)16-10-15(11-22)27(25-16)12-14-6-3-2-4-7-14/h2-10,17H,12-13H2,1H3,(H,24,28)/t17-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356431
PNG
(US9815850, Compound 163)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc(Cc3cccc(c3)C#N)[nH]2)C1=O
Show InChI InChI=1S/C21H18N6O3/c1-27-16-7-2-3-8-17(16)30-12-15(21(27)29)23-20(28)19-24-18(25-26-19)10-13-5-4-6-14(9-13)11-22/h2-9,15H,10,12H2,1H3,(H,23,28)(H,24,25,26)/t15-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356441
PNG
(US9815850, Compound 172)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncn(Cc2cccc(c2)C#N)n1
Show InChI InChI=1S/C21H19N7O3/c1-13-17(21(30)27(2)19-16(31-13)7-4-8-23-19)25-20(29)18-24-12-28(26-18)11-15-6-3-5-14(9-15)10-22/h3-9,12-13,17H,11H2,1-2H3,(H,25,29)/t13-,17+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356394
PNG
(US9815850, Compound 134 | US9815850, Compound 174)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C20H19N5O4/c1-12-16(20(27)25(2)17-14(28-12)9-6-10-21-17)22-18(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/m1/s1
PDB

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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356457
PNG
(US9815850, Compound 182B)
Show SMILES CN1c2nccnc2CC[C@H](NC(=O)c2nn(Cc3cccnc3C)cc2F)C1=O
Show InChI InChI=1S/C20H20FN7O2/c1-12-13(4-3-7-22-12)10-28-11-14(21)17(26-28)19(29)25-16-6-5-15-18(24-9-8-23-15)27(2)20(16)30/h3-4,7-9,11,16H,5-6,10H2,1-2H3,(H,25,29)/t16-/m0/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356460
PNG
(US9815850, Compound 184)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cnn(C)c3)cc2F)C1=O
Show InChI InChI=1S/C18H18FN7O3/c1-24-7-11(6-21-24)8-26-9-12(19)15(23-26)17(27)22-13-10-29-14-4-3-5-20-16(14)25(2)18(13)28/h3-7,9,13H,8,10H2,1-2H3,(H,22,27)/t13-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356479
PNG
(US9815850, Compound 214)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccc(F)cn3)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-16-4-2-3-5-17(16)30-11-15(20(26)29)24-19(28)18-14(22)10-27(25-18)9-13-7-6-12(21)8-23-13/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356482
PNG
(US9815850, Compound 217)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)s1
Show InChI InChI=1S/C20H19N5O3S/c1-12-16(20(27)25(2)17-14(28-12)9-6-10-21-17)22-18(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356484
PNG
(US9815850, Compound 219)
Show SMILES CN1c2ncccc2CC[C@H](NC(=O)c2ncc(Cc3cccc(c3)C#N)s2)C1=O
Show InChI InChI=1S/C22H19N5O2S/c1-27-19-16(6-3-9-24-19)7-8-18(22(27)29)26-20(28)21-25-13-17(30-21)11-14-4-2-5-15(10-14)12-23/h2-6,9-10,13,18H,7-8,11H2,1H3,(H,26,28)/t18-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356487
PNG
(US9815850, Compound 222)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1noc(Cc2ccccc2)n1
Show InChI InChI=1S/C20H19N5O4/c1-12-16(20(27)25(2)18-14(28-12)9-6-10-21-18)23-19(26)17-22-15(29-24-17)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,23,26)/t12-,16+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356488
PNG
(US9815850, Compound 223)
Show SMILES CN1c2nccnc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccc(F)cc3)o2)C1=O
Show InChI InChI=1S/C20H17FN6O3/c1-27-17-15(22-6-7-23-17)12-9-13(12)16(20(27)29)24-18(28)19-26-25-14(30-19)8-10-2-4-11(21)5-3-10/h2-7,12-13,16H,8-9H2,1H3,(H,24,28)/t12-,13+,16+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356489
PNG
(US9815850, Compound 224)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ncccn3)cc2F)C1=O
Show InChI InChI=1S/C19H17FN6O3/c1-25-14-5-2-3-6-15(14)29-11-13(19(25)28)23-18(27)17-12(20)9-26(24-17)10-16-21-7-4-8-22-16/h2-9,13H,10-11H2,1H3,(H,23,27)/t13-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356233
PNG
(US9815850, Compound 3)
Show SMILES CN1c2ccccc2C(=C)C[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C23H21N3O3/c1-15-12-20(23(28)26(2)21-11-7-6-10-18(15)21)24-22(27)19-14-17(29-25-19)13-16-8-4-3-5-9-16/h3-11,14,20H,1,12-13H2,2H3,(H,24,27)/t20-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356242
PNG
(US9815850, Compound 10)
Show SMILES CN1c2ccccc2C(F)(F)CC(NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1S/C21H19F2N5O2/c1-28-16-10-6-5-9-14(16)21(22,23)12-15(20(28)30)24-19(29)18-25-17(26-27-18)11-13-7-3-2-4-8-13/h2-10,15H,11-12H2,1H3,(H,24,29)(H,25,26,27)
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356249
PNG
(US9815850, Compound 13)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc3[C@H](CCn3n2)c2ccccc2)C1=O
Show InChI InChI=1S/C23H22N4O3/c1-26-19-9-5-6-10-21(19)30-14-18(23(26)29)24-22(28)17-13-20-16(11-12-27(20)25-17)15-7-3-2-4-8-15/h2-10,13,16,18H,11-12,14H2,1H3,(H,24,28)/t16-,18+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356294
PNG
(US9815850, Compound 64)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C21H19FN4O3/c1-25-17-9-5-6-10-18(17)29-13-16(21(25)28)23-20(27)19-15(22)12-26(24-19)11-14-7-3-2-4-8-14/h2-10,12,16H,11,13H2,1H3,(H,23,27)/t16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356303
PNG
(US9815850, Compound 70A)
Show SMILES O=C(N[C@H]1COc2ccccc2-n2cnnc12)c1cc(Cc2ccccc2)[nH]n1
Show InChI InChI=1S/C21H18N6O2/c28-21(16-11-15(24-25-16)10-14-6-2-1-3-7-14)23-17-12-29-19-9-5-4-8-18(19)27-13-22-26-20(17)27/h1-9,11,13,17H,10,12H2,(H,23,28)(H,24,25)/t17-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356320
PNG
(US9815850, Compound 82A)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C22H20FN5O2/c1-27-20-14(8-5-9-24-20)15-10-16(15)18(22(27)30)25-21(29)19-17(23)12-28(26-19)11-13-6-3-2-4-7-13/h2-9,12,15-16,18H,10-11H2,1H3,(H,25,29)/t15-,16-,18-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356345
PNG
(US9815850, Compound 101B)
Show SMILES CN1c2cnn(C)c2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1S/C19H21N7O2/c1-25-15-11-20-26(2)14(15)9-8-13(19(25)28)21-18(27)17-22-16(23-24-17)10-12-6-4-3-5-7-12/h3-7,11,13H,8-10H2,1-2H3,(H,21,27)(H,22,23,24)/t13-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356357
PNG
(US9815850, Compound 108)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1S/C20H19N5O3/c1-25-18-16(8-5-9-21-18)28-12-15(20(25)27)24-19(26)14-11-22-17(23-14)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,22,23)(H,24,26)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356358
PNG
(US9815850, Compound 109A)
Show SMILES CN1c2cn(C)nc2CC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C20H21FN6O2/c1-25-12-17-15(23-25)8-9-16(20(29)26(17)2)22-19(28)18-14(21)11-27(24-18)10-13-6-4-3-5-7-13/h3-7,11-12,16H,8-10H2,1-2H3,(H,22,28)/t16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356370
PNG
(US9815850, Compound 117)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cc(Oc2ccccc2F)ccn1
Show InChI InChI=1S/C22H19FN4O4/c1-13-19(22(29)27(2)20-18(30-13)8-5-10-25-20)26-21(28)16-12-14(9-11-24-16)31-17-7-4-3-6-15(17)23/h3-13,19H,1-2H3,(H,26,28)/t13-,19+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356395
PNG
(US9815850, Compound 135)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cccc(F)c3)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-18-16(6-3-7-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-4-2-5-13(21)8-12/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356412
PNG
(US9815850, Compound 149)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(Oc3ccccc3F)cnn2)C1=O
Show InChI InChI=1S/C20H16FN5O4/c1-26-18-17(7-4-8-22-18)29-11-15(20(26)28)24-19(27)14-9-12(10-23-25-14)30-16-6-3-2-5-13(16)21/h2-10,15H,11H2,1H3,(H,24,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356413
PNG
(US9815850, Compound 150)
Show SMILES C[C@H]1Oc2cc(cnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)[nH]1)C#N
Show InChI InChI=1S/C21H19N7O3/c1-12-17(21(30)28(2)19-15(31-12)8-14(10-22)11-23-19)25-20(29)18-24-16(26-27-18)9-13-6-4-3-5-7-13/h3-8,11-12,17H,9H2,1-2H3,(H,25,29)(H,24,26,27)/t12-,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356416
PNG
(US9815850, Compound 152B)
Show SMILES CN1c2ncccc2CC[C@H](NC(=O)c2nn(Cc3cccc(c3)C#N)cc2F)C1=O
Show InChI InChI=1S/C22H19FN6O2/c1-28-20-16(6-3-9-25-20)7-8-18(22(28)31)26-21(30)19-17(23)13-29(27-19)12-15-5-2-4-14(10-15)11-24/h2-6,9-10,13,18H,7-8,12H2,1H3,(H,26,30)/t18-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356424
PNG
(US9815850, Compound 157B)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccccc3)o2)C1=O
Show InChI InChI=1S/C21H19N5O3/c1-26-18-13(8-5-9-22-18)14-11-15(14)17(21(26)28)23-19(27)20-25-24-16(29-20)10-12-6-3-2-4-7-12/h2-9,14-15,17H,10-11H2,1H3,(H,23,27)/t14-,15-,17-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356430
PNG
(US9815850, Compound 162)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3cc(F)cc(c3)C#N)[nH]2)C1=O
Show InChI InChI=1S/C20H16FN7O3/c1-28-18-15(3-2-4-23-18)31-10-14(20(28)30)24-19(29)17-25-16(26-27-17)8-11-5-12(9-22)7-13(21)6-11/h2-7,14H,8,10H2,1H3,(H,24,29)(H,25,26,27)/t14-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356312
PNG
(US9815850, Compound 175 | US9815850, Compound 76)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C20H18FN5O3/c1-25-18-16(8-5-9-22-18)29-12-15(20(25)28)23-19(27)17-14(21)11-26(24-17)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,27)/t15-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356445
PNG
(US9815850, Compound 176)
Show SMILES Fc1cc(F)c2NC(=O)[C@@H](NC(=O)c3nnc(Cc4ccccc4)[nH]3)[C@@H]3C[C@@H]3c2c1
Show InChI InChI=1S/C21H17F2N5O2/c22-11-7-13-12-9-14(12)18(20(29)25-17(13)15(23)8-11)26-21(30)19-24-16(27-28-19)6-10-4-2-1-3-5-10/h1-5,7-8,12,14,18H,6,9H2,(H,25,29)(H,26,30)(H,24,27,28)/t12-,14-,18+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356480
PNG
(US9815850, Compound 215)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2noc(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C19H17N5O4/c1-24-17-14(8-5-9-20-17)27-11-13(19(24)26)21-18(25)16-22-15(28-23-16)10-12-6-3-2-4-7-12/h2-9,13H,10-11H2,1H3,(H,21,25)/t13-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356230
PNG
(US9815850, Compound 2 | US9815850, Compound 2A | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356246
PNG
(US9815850, Compound 12 | US9815850, Compound 12A)
Show SMILES CN1c2ccccc2[C@@H](F)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1S/C21H20FN5O2/c1-27-17-10-6-5-9-14(17)15(22)12-16(21(27)29)23-20(28)19-24-18(25-26-19)11-13-7-3-2-4-8-13/h2-10,15-16H,11-12H2,1H3,(H,23,28)(H,24,25,26)/t15-,16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356282
PNG
(US9815850, Compound 54A | US9815850, Compound 54B)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O
Show InChI InChI=1S/C21H20N6O3/c1-27-19-16(7-4-10-22-19)30-11-15(21(27)29)23-20(28)18-24-17(25-26-18)14-9-8-12-5-2-3-6-13(12)14/h2-7,10,14-15H,8-9,11H2,1H3,(H,23,28)(H,24,25,26)/t14?,15-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
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UniChem
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US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


Article DOI: 10.1021/jm061182w
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%