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Patent code US9822124

Compile Data Set for Download or QSAR

Found 255 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359937
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2sc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O2S/c1-13-10-30(12-15(24)22(13)31)19-5-6-25-9-18(19)28-23(32)16-3-4-20-17(27-16)7-21(33-20)14-8-26-29(2)11-14/h3-9,11,13,15,22,31H,10,12,24H2,1-2H3,(H,28,32)/t13-,15+,22+/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359939
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES CCCc1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C22H27N5OS/c1-3-4-16-10-18-21(29-16)6-5-17(25-18)22(28)26-19-11-24-8-7-20(19)27-12-14(2)9-15(23)13-27/h5-8,10-11,14-15H,3-4,9,12-13,23H2,1-2H3,(H,26,28)/t14-,15+/m1/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359940
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES CC(C)c1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C22H27N5OS/c1-13(2)21-9-17-20(29-21)5-4-16(25-17)22(28)26-18-10-24-7-6-19(18)27-11-14(3)8-15(23)12-27/h4-7,9-10,13-15H,8,11-12,23H2,1-3H3,(H,26,28)/t14-,15+/m1/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359943
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2sc(cc2n1)-c1ccccc1F
Show InChI InChI=1S/C25H24FN5OS/c1-15-10-16(27)14-31(13-15)22-8-9-28-12-21(22)30-25(32)19-6-7-23-20(29-19)11-24(33-23)17-4-2-3-5-18(17)26/h2-9,11-12,15-16H,10,13-14,27H2,1H3,(H,30,32)/t15-,16+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359949
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES COc1ccc(cn1)-c1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C25H26N6O2S/c1-15-9-17(26)14-31(13-15)21-7-8-27-12-20(21)30-25(32)18-4-5-22-19(29-18)10-23(34-22)16-3-6-24(33-2)28-11-16/h3-8,10-12,15,17H,9,13-14,26H2,1-2H3,(H,30,32)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359954
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2sc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C25H25N5OS/c1-16-11-18(26)15-30(14-16)22-9-10-27-13-21(22)29-25(31)19-7-8-23-20(28-19)12-24(32-23)17-5-3-2-4-6-17/h2-10,12-13,16,18H,11,14-15,26H2,1H3,(H,29,31)/t16-,18+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359957
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2sc(C)cc2n1
Show InChI InChI=1S/C20H23N5OS/c1-12-7-14(21)11-25(10-12)18-5-6-22-9-17(18)24-20(26)15-3-4-19-16(23-15)8-13(2)27-19/h3-6,8-9,12,14H,7,10-11,21H2,1-2H3,(H,24,26)/t12-,14+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359962
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl}-3-e...)
Show SMILES CCc1csc2ccc(nc12)C(=O)Nc1cnccc1N1CCC[C@H](N)C1
Show InChI InChI=1S/C20H23N5OS/c1-2-13-12-27-18-6-5-15(23-19(13)18)20(26)24-16-10-22-8-7-17(16)25-9-3-4-14(21)11-25/h5-8,10,12,14H,2-4,9,11,21H2,1H3,(H,24,26)/t14-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359963
PNG
((S)-N-(4-(3-Aminopiperidin-1-yl)pyridin-3-yl)-3-cy...)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1ccc2scc(C3CC3)c2n1
Show InChI InChI=1S/C21H23N5OS/c22-14-2-1-9-26(11-14)18-7-8-23-10-17(18)25-21(27)16-5-6-19-20(24-16)15(12-28-19)13-3-4-13/h5-8,10,12-14H,1-4,9,11,22H2,(H,25,27)/t14-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359971
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2cc(oc2n1)C1CC1
Show InChI InChI=1S/C22H25N5O2/c1-13-8-16(23)12-27(11-13)19-6-7-24-10-18(19)25-21(28)17-5-4-15-9-20(14-2-3-14)29-22(15)26-17/h4-7,9-10,13-14,16H,2-3,8,11-12,23H2,1H3,(H,25,28)/t13-,16+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359975
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CC1c1cc2ccc(nc2o1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C23H27N5O3/c1-12-7-15(12)20-8-14-3-4-17(27-23(14)31-20)22(30)26-18-9-25-6-5-19(18)28-10-13(2)21(29)16(24)11-28/h3-6,8-9,12-13,15-16,21,29H,7,10-11,24H2,1-2H3,(H,26,30)/t12-,13-,15?,16+,21+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359976
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1CC1c1cc2ccc(nc2o1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C23H27N5O2/c1-13-7-16(24)12-28(11-13)20-5-6-25-10-19(20)26-22(29)18-4-3-15-9-21(17-8-14(17)2)30-23(15)27-18/h3-6,9-10,13-14,16-17H,7-8,11-12,24H2,1-2H3,(H,26,29)/t13-,14-,16+,17?/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359984
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@H]1CC1c1cc2ccc(nc2o1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C23H27N5O2/c1-13-7-16(24)12-28(11-13)20-5-6-25-10-19(20)26-22(29)18-4-3-15-9-21(17-8-14(17)2)30-23(15)27-18/h3-6,9-10,13-14,16-17H,7-8,11-12,24H2,1-2H3,(H,26,29)/t13-,14+,16+,17?/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359986
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccn(C3CCC3)c2n1
Show InChI InChI=1S/C23H28N6O/c1-15-11-17(24)14-28(13-15)21-7-9-25-12-20(21)27-23(30)19-6-5-16-8-10-29(22(16)26-19)18-3-2-4-18/h5-10,12,15,17-18H,2-4,11,13-14,24H2,1H3,(H,27,30)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM360022
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES CC(C)c1cnn2ccc(nc12)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C22H28N6O/c1-13(2)18-11-25-28-7-5-19(26-21(18)28)22(29)27-20-12-24-6-4-17(20)15-8-14(3)9-16(23)10-15/h4-7,11-16H,8-10,23H2,1-3H3,(H,27,29)/t14-,15+,16-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM360025
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccn2ncc(-c3c(F)cccc3F)c2n1
Show InChI InChI=1S/C25H24F2N6O/c1-14-9-15(11-16(28)10-14)17-5-7-29-13-22(17)32-25(34)21-6-8-33-24(31-21)18(12-30-33)23-19(26)3-2-4-20(23)27/h2-8,12-16H,9-11,28H2,1H3,(H,32,34)/t14-,15+,16-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM360027
PNG
(US9822124, Example 85)
Show SMILES CCc1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C21H25N5O2S/c1-3-13-8-16-19(29-13)5-4-15(24-16)21(28)25-17-9-23-7-6-18(17)26-10-12(2)20(27)14(22)11-26/h4-9,12,14,20,27H,3,10-11,22H2,1-2H3,(H,25,28)/t12-,14+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359881
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CC(C)c1cc2nc(ccc2o1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C22H27N5O2/c1-13(2)21-9-17-20(29-21)5-4-16(25-17)22(28)26-18-10-24-7-6-19(18)27-11-14(3)8-15(23)12-27/h4-7,9-10,13-15H,8,11-12,23H2,1-3H3,(H,26,28)/t14-,15+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359882
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES COc1ccc(cn1)-c1cc2nc(ccc2o1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C25H26N6O3/c1-15-9-17(26)14-31(13-15)21-7-8-27-12-20(21)30-25(32)18-4-5-22-19(29-18)10-23(34-22)16-3-6-24(33-2)28-11-16/h3-8,10-12,15,17H,9,13-14,26H2,1-2H3,(H,30,32)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359884
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2oc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C28H31N7O3/c1-18-12-20(29)17-35(16-18)24-6-7-30-15-23(24)33-28(36)21-3-4-25-22(32-21)13-26(38-25)19-2-5-27(31-14-19)34-8-10-37-11-9-34/h2-7,13-15,18,20H,8-12,16-17,29H2,1H3,(H,33,36)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359886
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1cc2nc(ccc2o1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C25H26N6O4/c1-14-12-31(13-16(26)24(14)32)20-7-8-27-11-19(20)30-25(33)17-4-5-21-18(29-17)9-22(35-21)15-3-6-23(34-2)28-10-15/h3-11,14,16,24,32H,12-13,26H2,1-2H3,(H,30,33)/t14-,16+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359890
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1coc2ccc(nc12)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C22H27N5O3/c1-12(2)14-11-30-19-5-4-16(25-20(14)19)22(29)26-17-8-24-7-6-18(17)27-9-13(3)21(28)15(23)10-27/h4-8,11-13,15,21,28H,9-10,23H2,1-3H3,(H,26,29)/t13-,15+,21+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359892
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2occ(-c3ccccc3F)c2n1
Show InChI InChI=1S/C25H24FN5O3/c1-14-11-31(12-18(27)24(14)32)21-8-9-28-10-20(21)30-25(33)19-6-7-22-23(29-19)16(13-34-22)15-4-2-3-5-17(15)26/h2-10,13-14,18,24,32H,11-12,27H2,1H3,(H,30,33)/t14-,18+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359893
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(F)c(-c2coc3ccc(nc23)C(=O)Nc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)c1F
Show InChI InChI=1S/C26H25F2N5O4/c1-13-10-33(11-16(29)25(13)34)19-7-8-30-9-18(19)32-26(35)17-4-6-21-24(31-17)14(12-37-21)22-15(27)3-5-20(36-2)23(22)28/h3-9,12-13,16,25,34H,10-11,29H2,1-2H3,(H,32,35)/t13-,16+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359893
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(F)c(-c2coc3ccc(nc23)C(=O)Nc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)c1F
Show InChI InChI=1S/C26H25F2N5O4/c1-13-10-33(11-16(29)25(13)34)19-7-8-30-9-18(19)32-26(35)17-4-6-21-24(31-17)14(12-37-21)22-15(27)3-5-20(36-2)23(22)28/h3-9,12-13,16,25,34H,10-11,29H2,1-2H3,(H,32,35)/t13-,16+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359903
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES COc1ccc(F)c(-c2coc3ccc(nc23)C(=O)Nc2cnccc2N2C[C@H](C)C[C@H](N)C2)c1F
Show InChI InChI=1S/C26H25F2N5O3/c1-14-9-15(29)12-33(11-14)20-7-8-30-10-19(20)32-26(34)18-4-6-22-25(31-18)16(13-36-22)23-17(27)3-5-21(35-2)24(23)28/h3-8,10,13-15H,9,11-12,29H2,1-2H3,(H,32,34)/t14-,15+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359907
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2occ(C3CCOCC3)c2n1
Show InChI InChI=1S/C24H29N5O3/c1-15-10-17(25)13-29(12-15)21-4-7-26-11-20(21)28-24(30)19-2-3-22-23(27-19)18(14-32-22)16-5-8-31-9-6-16/h2-4,7,11,14-17H,5-6,8-10,12-13,25H2,1H3,(H,28,30)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359922
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCCc1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C22H27N5O2S/c1-3-4-14-9-17-20(30-14)6-5-16(25-17)22(29)26-18-10-24-8-7-19(18)27-11-13(2)21(28)15(23)12-27/h5-10,13,15,21,28H,3-4,11-12,23H2,1-2H3,(H,26,29)/t13-,15+,21+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359923
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C22H27N5O2S/c1-12(2)20-8-16-19(30-20)5-4-15(25-16)22(29)26-17-9-24-7-6-18(17)27-10-13(3)21(28)14(23)11-27/h4-9,12-14,21,28H,10-11,23H2,1-3H3,(H,26,29)/t13-,14+,21+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359928
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C25H26N6O3S/c1-14-12-31(13-16(26)24(14)32)20-7-8-27-11-19(20)30-25(33)17-4-5-21-18(29-17)9-22(35-21)15-3-6-23(34-2)28-10-15/h3-11,14,16,24,32H,12-13,26H2,1-2H3,(H,30,33)/t14-,16+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359929
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2sc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C28H31N7O3S/c1-17-15-35(16-19(29)27(17)36)23-6-7-30-14-22(23)33-28(37)20-3-4-24-21(32-20)12-25(39-24)18-2-5-26(31-13-18)34-8-10-38-11-9-34/h2-7,12-14,17,19,27,36H,8-11,15-16,29H2,1H3,(H,33,37)/t17-,19+,27+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359936
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2sc(cc2n1)C1CC1
Show InChI InChI=1S/C22H25N5O2S/c1-12-10-27(11-14(23)21(12)28)18-6-7-24-9-17(18)26-22(29)15-4-5-19-16(25-15)8-20(30-19)13-2-3-13/h4-9,12-14,21,28H,2-3,10-11,23H2,1H3,(H,26,29)/t12-,14+,21+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359944
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2sc(Cc3ccccc3)cc2n1
Show InChI InChI=1S/C26H27N5OS/c1-17-11-19(27)16-31(15-17)24-9-10-28-14-23(24)30-26(32)21-7-8-25-22(29-21)13-20(33-25)12-18-5-3-2-4-6-18/h2-10,13-14,17,19H,11-12,15-16,27H2,1H3,(H,30,32)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359967
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES CC(C)c1coc2ccc(nc12)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C23H28N4O2/c1-13(2)18-12-29-21-5-4-19(26-22(18)21)23(28)27-20-11-25-7-6-17(20)15-8-14(3)9-16(24)10-15/h4-7,11-16H,8-10,24H2,1-3H3,(H,27,28)/t14-,15+,16-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359972
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2cc(oc2n1)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-16-14-33(15-21(29)26(16)34)24-9-10-30-13-23(24)31-27(35)22-8-7-18-11-25(36-28(18)32-22)20-12-19(20)17-5-3-2-4-6-17/h2-11,13,16,19-21,26,34H,12,14-15,29H2,1H3,(H,31,35)/t16-,19-,20+,21+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359986
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccn(C3CCC3)c2n1
Show InChI InChI=1S/C23H28N6O/c1-15-11-17(24)14-28(13-15)21-7-9-25-12-20(21)27-23(30)19-6-5-16-8-10-29(22(16)26-19)18-3-2-4-18/h5-10,12,15,17-18H,2-4,11,13-14,24H2,1H3,(H,27,30)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM360025
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccn2ncc(-c3c(F)cccc3F)c2n1
Show InChI InChI=1S/C25H24F2N6O/c1-14-9-15(11-16(28)10-14)17-5-7-29-13-22(17)32-25(34)21-6-8-33-24(31-21)18(12-30-33)23-19(26)3-2-4-20(23)27/h2-8,12-16H,9-11,28H2,1H3,(H,32,34)/t14-,15+,16-/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359925
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2sc(cc2n1)-c1ccccc1F
Show InChI InChI=1S/C25H24FN5O2S/c1-14-12-31(13-17(27)24(14)32)21-8-9-28-11-20(21)30-25(33)18-6-7-22-19(29-18)10-23(34-22)15-4-2-3-5-16(15)26/h2-11,14,17,24,32H,12-13,27H2,1H3,(H,30,33)/t14-,17+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359938
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2sc(C)cc2n1
Show InChI InChI=1S/C20H23N5O2S/c1-11-9-25(10-13(21)19(11)26)17-5-6-22-8-16(17)24-20(27)14-3-4-18-15(23-14)7-12(2)28-18/h3-8,11,13,19,26H,9-10,21H2,1-2H3,(H,24,27)/t11-,13+,19+/m0/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359940
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES CC(C)c1cc2nc(ccc2s1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C22H27N5OS/c1-13(2)21-9-17-20(29-21)5-4-16(25-17)22(28)26-18-10-24-7-6-19(18)27-11-14(3)8-15(23)12-27/h4-7,9-10,13-15H,8,11-12,23H2,1-3H3,(H,26,28)/t14-,15+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359954
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2sc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C25H25N5OS/c1-16-11-18(26)15-30(14-16)22-9-10-27-13-21(22)29-25(31)19-7-8-23-20(28-19)12-24(32-23)17-5-3-2-4-6-17/h2-10,12-13,16,18H,11,14-15,26H2,1H3,(H,29,31)/t16-,18+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359956
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2sc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7OS/c1-14-7-16(24)13-30(11-14)20-5-6-25-10-19(20)28-23(31)17-3-4-21-18(27-17)8-22(32-21)15-9-26-29(2)12-15/h3-6,8-10,12,14,16H,7,11,13,24H2,1-2H3,(H,28,31)/t14-,16+/m1/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359962
PNG
(N-{4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl}-3-e...)
Show SMILES CCc1csc2ccc(nc12)C(=O)Nc1cnccc1N1CCC[C@H](N)C1
Show InChI InChI=1S/C20H23N5OS/c1-2-13-12-27-18-6-5-15(23-19(13)18)20(26)24-16-10-22-8-7-17(16)25-9-3-4-14(21)11-25/h5-8,10,12,14H,2-4,9,11,21H2,1H3,(H,24,26)/t14-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM359970
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2cc(oc2n1)C1CC1
Show InChI InChI=1S/C22H25N5O3/c1-12-10-27(11-15(23)20(12)28)18-6-7-24-9-17(18)25-21(29)16-5-4-14-8-19(13-2-3-13)30-22(14)26-16/h4-9,12-13,15,20,28H,2-3,10-11,23H2,1H3,(H,25,29)/t12-,15+,20+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359976
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1CC1c1cc2ccc(nc2o1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C23H27N5O2/c1-13-7-16(24)12-28(11-13)20-5-6-25-10-19(20)26-22(29)18-4-3-15-9-21(17-8-14(17)2)30-23(15)27-18/h3-6,9-10,13-14,16-17H,7-8,11-12,24H2,1-2H3,(H,26,29)/t13-,14-,16+,17?/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359994
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2sc(nc2n1)C1CC1
Show InChI InChI=1S/C21H24N6O2S/c1-11-9-27(10-13(22)18(11)28)16-6-7-23-8-15(16)25-20(29)14-4-5-17-19(24-14)26-21(30-17)12-2-3-12/h4-8,11-13,18,28H,2-3,9-10,22H2,1H3,(H,25,29)/t11-,13+,18+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM360021
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccn2ncc(-c3c(F)cc(CO)cc3F)c2n1
Show InChI InChI=1S/C26H26F2N6O2/c1-14-6-16(10-17(29)7-14)18-2-4-30-12-23(18)33-26(36)22-3-5-34-25(32-22)19(11-31-34)24-20(27)8-15(13-35)9-21(24)28/h2-5,8-9,11-12,14,16-17,35H,6-7,10,13,29H2,1H3,(H,33,36)/t14-,16+,17-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM360026
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES COc1cc(F)c(-c2cnn3ccc(nc23)C(=O)Nc2cnccc2[C@@H]2C[C@H](C)C[C@H](N)C2)c(F)c1
Show InChI InChI=1S/C26H26F2N6O2/c1-14-7-15(9-16(29)8-14)18-3-5-30-13-23(18)33-26(35)22-4-6-34-25(32-22)19(12-31-34)24-20(27)10-17(36-2)11-21(24)28/h3-6,10-16H,7-9,29H2,1-2H3,(H,33,35)/t14-,15+,16-/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359880
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES CCCc1cc2nc(ccc2o1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C22H27N5O2/c1-3-4-16-10-18-21(29-16)6-5-17(25-18)22(28)26-19-11-24-8-7-20(19)27-12-14(2)9-15(23)13-27/h5-8,10-11,14-15H,3-4,9,12-13,23H2,1-2H3,(H,26,28)/t14-,15+/m1/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM359891
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2occ(-c3c(F)cccc3F)c2n1
Show InChI InChI=1S/C25H23F2N5O3/c1-13-10-32(11-17(28)24(13)33)20-7-8-29-9-19(20)31-25(34)18-5-6-21-23(30-18)14(12-35-21)22-15(26)3-2-4-16(22)27/h2-9,12-13,17,24,33H,10-11,28H2,1H3,(H,31,34)/t13-,17+,24+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9822124 (2017)

More data for this
Ligand-Target Pair
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