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Patent code US9828343

Compile Data Set for Download or QSAR
Found 199 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314152
PNG
(3-[(3,4-dihydro-2H-chromen-4-ylmethyl)amino]pyridi...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314154
PNG
(3-{[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314125
PNG
(3-[(1H-indol-7-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2cc[nH]c12
Show InChI InChI=1S/C15H13N3O2/c19-15(20)12-5-6-16-9-13(12)18-8-11-3-1-2-10-4-7-17-14(10)11/h1-7,9,17-18H,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314126
PNG
(3-[(2-cyclopropyl-3-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1cccc(CNc2cnccc2C(O)=O)c1C1CC1
Show InChI InChI=1S/C17H18N2O2/c1-11-3-2-4-13(16(11)12-5-6-12)9-19-15-10-18-8-7-14(15)17(20)21/h2-4,7-8,10,12,19H,5-6,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314126
PNG
(3-[(2-cyclopropyl-3-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1cccc(CNc2cnccc2C(O)=O)c1C1CC1
Show InChI InChI=1S/C17H18N2O2/c1-11-3-2-4-13(16(11)12-5-6-12)9-19-15-10-18-8-7-14(15)17(20)21/h2-4,7-8,10,12,19H,5-6,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314128
PNG
(3-{[3-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314129
PNG
(3-[(2-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)16-10-11-20-13-17(16)21-12-14-6-4-5-9-18(14)24-15-7-2-1-3-8-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314133
PNG
(3-{[3-(cyclopropylmethoxy)benzyl]amino}pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C17H18N2O3/c20-17(21)15-6-7-18-10-16(15)19-9-13-2-1-3-14(8-13)22-11-12-4-5-12/h1-3,6-8,10,12,19H,4-5,9,11H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314136
PNG
(3-{[(5-methylfuran-2-yl)methyl]amino}pyridine-4-ca...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)o1
Show InChI InChI=1S/C12H12N2O3/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314140
PNG
(3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]p...)
Show SMILES OC(=O)c1ccncc1NCC1COc2ccccc2O1
Show InChI InChI=1S/C15H14N2O4/c18-15(19)11-5-6-16-8-12(11)17-7-10-9-20-13-3-1-2-4-14(13)21-10/h1-6,8,10,17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314116
PNG
(3-[(4-chloro-2-methoxybenzyl)amino]pyridine-4-carb...)
Show SMILES COc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O3/c1-20-13-6-10(15)3-2-9(13)7-17-12-8-16-5-4-11(12)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314118
PNG
(3-[(2-aminobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES Nc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C13H13N3O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7,14H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314121
PNG
(3-[(4-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-11-1-3-12(4-2-11)13-5-6-13/h1-4,7-8,10,13,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50153334
PNG
(CHEMBL3774545 | US10179769, Example 39 | US9611221...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)s1
Show InChI InChI=1S/C12H12N2O2S/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50158791
PNG
(CHEMBL3786596 | US10179769, Example 42 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H22N2O2/c20-16(21)14-1-2-18-9-15(14)19-10-17-6-11-3-12(7-17)5-13(4-11)8-17/h1-2,9,11-13,19H,3-8,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314141
PNG
(3-[(2,3-dihydro-1H-inden-1-ylmethylbenzyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCc2ccccc12
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-6-5-11-3-1-2-4-13(11)12/h1-4,7-8,10,12,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314152
PNG
(3-[(3,4-dihydro-2H-chromen-4-ylmethyl)amino]pyridi...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314156
PNG
(3-{[(6-methyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES Cc1ccc2OCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-11-2-3-16-14(8-11)12(5-7-22-16)9-19-15-10-18-6-4-13(15)17(20)21/h2-4,6,8,10,12,19H,5,7,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314124
PNG
(3-[(naphthalene-1-ylmethyl)amino]pyridine-4-carbox...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-9,11,19H,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314126
PNG
(3-[(2-cyclopropyl-3-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1cccc(CNc2cnccc2C(O)=O)c1C1CC1
Show InChI InChI=1S/C17H18N2O2/c1-11-3-2-4-13(16(11)12-5-6-12)9-19-15-10-18-8-7-14(15)17(20)21/h2-4,7-8,10,12,19H,5-6,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314130
PNG
(3-[(2-cyclopropyl-5-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1ccc(C2CC2)c(CNc2cnccc2C(O)=O)c1
Show InChI InChI=1S/C17H18N2O2/c1-11-2-5-14(12-3-4-12)13(8-11)9-19-16-10-18-7-6-15(16)17(20)21/h2,5-8,10,12,19H,3-4,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314132
PNG
(3-{[2-(phenylamino)benzyl]amino}pyridine-4-carboxy...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c23-19(24)16-10-11-20-13-18(16)21-12-14-6-4-5-9-17(14)22-15-7-2-1-3-8-15/h1-11,13,21-22H,12H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314132
PNG
(3-{[2-(phenylamino)benzyl]amino}pyridine-4-carboxy...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c23-19(24)16-10-11-20-13-18(16)21-12-14-6-4-5-9-17(14)22-15-7-2-1-3-8-15/h1-11,13,21-22H,12H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314134
PNG
(3-[(1-benzofuran-3-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1coc2ccccc12
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-8-13(12)17-7-10-9-20-14-4-2-1-3-11(10)14/h1-6,8-9,17H,7H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314136
PNG
(3-{[(5-methylfuran-2-yl)methyl]amino}pyridine-4-ca...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)o1
Show InChI InChI=1S/C12H12N2O3/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314141
PNG
(3-[(2,3-dihydro-1H-inden-1-ylmethylbenzyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCc2ccccc12
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-6-5-11-3-1-2-4-13(11)12/h1-4,7-8,10,12,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314148
PNG
(3-{[(7-cyclopropyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)C1CC1
Show InChI InChI=1S/C20H22N2O2/c23-20(24)17-8-9-21-12-19(17)22-11-16-3-1-2-14-6-7-15(10-18(14)16)13-4-5-13/h6-10,12-13,16,22H,1-5,11H2,(H,23,24)
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Celgene Quanticel Research, Inc.

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Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314152
PNG
(3-[(3,4-dihydro-2H-chromen-4-ylmethyl)amino]pyridi...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

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Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314164
PNG
(3-{[(8-fluoro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2c(F)cccc12
Show InChI InChI=1S/C16H15FN2O3/c17-13-3-1-2-11-10(5-7-22-15(11)13)8-19-14-9-18-6-4-12(14)16(20)21/h1-4,6,9-10,19H,5,7-8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314117
PNG
(3-[(4-chloro-2-hydroxybenzyl)amino]pyridine-4-carb...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1O
Show InChI InChI=1S/C13H11ClN2O3/c14-9-2-1-8(12(17)5-9)6-16-11-7-15-4-3-10(11)13(18)19/h1-5,7,16-17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314117
PNG
(3-[(4-chloro-2-hydroxybenzyl)amino]pyridine-4-carb...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1O
Show InChI InChI=1S/C13H11ClN2O3/c14-9-2-1-8(12(17)5-9)6-16-11-7-15-4-3-10(11)13(18)19/h1-5,7,16-17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314119
PNG
(3-[(4-bromobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314122
PNG
(3-[(4-chloro-2-cyclopropylbenzyl)amino]pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1C1CC1
Show InChI InChI=1S/C16H15ClN2O2/c17-12-4-3-11(14(7-12)10-1-2-10)8-19-15-9-18-6-5-13(15)16(20)21/h3-7,9-10,19H,1-2,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314124
PNG
(3-[(naphthalene-1-ylmethyl)amino]pyridine-4-carbox...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-9,11,19H,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314125
PNG
(3-[(1H-indol-7-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2cc[nH]c12
Show InChI InChI=1S/C15H13N3O2/c19-15(20)12-5-6-16-9-13(12)18-8-11-3-1-2-10-4-7-17-14(10)11/h1-7,9,17-18H,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314141
PNG
(3-[(2,3-dihydro-1H-inden-1-ylmethylbenzyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCc2ccccc12
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-6-5-11-3-1-2-4-13(11)12/h1-4,7-8,10,12,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314148
PNG
(3-{[(7-cyclopropyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)C1CC1
Show InChI InChI=1S/C20H22N2O2/c23-20(24)17-8-9-21-12-19(17)22-11-16-3-1-2-14-6-7-15(10-18(14)16)13-4-5-13/h6-10,12-13,16,22H,1-5,11H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314158
PNG
(3-{[(6-fluoro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(F)ccc12
Show InChI InChI=1S/C16H15FN2O3/c17-11-1-2-12-10(4-6-22-15(12)7-11)8-19-14-9-18-5-3-13(14)16(20)21/h1-3,5,7,9-10,19H,4,6,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314118
PNG
(3-[(2-aminobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES Nc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C13H13N3O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7,14H2,(H,17,18)
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US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314120
PNG
(3-[(4-methylbenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O2/c1-10-2-4-11(5-3-10)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314121
PNG
(3-[(4-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-11-1-3-12(4-2-11)13-5-6-13/h1-4,7-8,10,13,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314124
PNG
(3-[(naphthalene-1-ylmethyl)amino]pyridine-4-carbox...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-9,11,19H,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314125
PNG
(3-[(1H-indol-7-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2cc[nH]c12
Show InChI InChI=1S/C15H13N3O2/c19-15(20)12-5-6-16-9-13(12)18-8-11-3-1-2-10-4-7-17-14(10)11/h1-7,9,17-18H,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314127
PNG
(3-{[(4-cyclopropylpyridin-3-yl)-methyl]amino}pyrid...)
Show SMILES OC(=O)c1ccncc1NCc1cnccc1C1CC1
Show InChI InChI=1S/C15H15N3O2/c19-15(20)13-4-6-17-9-14(13)18-8-11-7-16-5-3-12(11)10-1-2-10/h3-7,9-10,18H,1-2,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314137
PNG
(3-[(1-benzofuran-2-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1cc2ccccc2o1
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-7,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314137
PNG
(3-[(1-benzofuran-2-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1cc2ccccc2o1
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-7,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314139
PNG
(3-[(2,3-dihydro-1-benzofuran-2-ylmethyl)amino]pyri...)
Show SMILES OC(=O)c1ccncc1NCC1Cc2ccccc2O1
Show InChI InChI=1S/C15H14N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-6,9,11,17H,7-8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314156
PNG
(3-{[(6-methyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES Cc1ccc2OCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-11-2-3-16-14(8-11)12(5-7-22-16)9-19-15-10-18-6-4-13(15)17(20)21/h2-4,6,8,10,12,19H,5,7,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314105
PNG
(3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314116
PNG
(3-[(4-chloro-2-methoxybenzyl)amino]pyridine-4-carb...)
Show SMILES COc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O3/c1-20-13-6-10(15)3-2-9(13)7-17-12-8-16-5-4-11(12)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314117
PNG
(3-[(4-chloro-2-hydroxybenzyl)amino]pyridine-4-carb...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1O
Show InChI InChI=1S/C13H11ClN2O3/c14-9-2-1-8(12(17)5-9)6-16-11-7-15-4-3-10(11)13(18)19/h1-5,7,16-17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314119
PNG
(3-[(4-bromobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314120
PNG
(3-[(4-methylbenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O2/c1-10-2-4-11(5-3-10)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314122
PNG
(3-[(4-chloro-2-cyclopropylbenzyl)amino]pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1C1CC1
Show InChI InChI=1S/C16H15ClN2O2/c17-12-4-3-11(14(7-12)10-1-2-10)8-19-15-9-18-6-5-13(15)16(20)21/h3-7,9-10,19H,1-2,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314127
PNG
(3-{[(4-cyclopropylpyridin-3-yl)-methyl]amino}pyrid...)
Show SMILES OC(=O)c1ccncc1NCc1cnccc1C1CC1
Show InChI InChI=1S/C15H15N3O2/c19-15(20)13-4-6-17-9-14(13)18-8-11-7-16-5-3-12(11)10-1-2-10/h3-7,9-10,18H,1-2,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314134
PNG
(3-[(1-benzofuran-3-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1coc2ccccc12
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-8-13(12)17-7-10-9-20-14-4-2-1-3-11(10)14/h1-6,8-9,17H,7H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50153334
PNG
(CHEMBL3774545 | US10179769, Example 39 | US9611221...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)s1
Show InChI InChI=1S/C12H12N2O2S/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314136
PNG
(3-{[(5-methylfuran-2-yl)methyl]amino}pyridine-4-ca...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)o1
Show InChI InChI=1S/C12H12N2O3/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314137
PNG
(3-[(1-benzofuran-2-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1cc2ccccc2o1
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-7,9,17H,8H2,(H,18,19)
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Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314142
PNG
(3-[(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)amino]...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314145
PNG
(3-{[(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(F)cc12
Show InChI InChI=1S/C17H17FN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314118
PNG
(3-[(2-aminobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES Nc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C13H13N3O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7,14H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314119
PNG
(3-[(4-bromobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314120
PNG
(3-[(4-methylbenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O2/c1-10-2-4-11(5-3-10)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314123
PNG
(3-{[2-cyclopropyl-4-(trifluoromethyl)benzyl]amino}...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1C1CC1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N2O2/c18-17(19,20)12-4-3-11(14(7-12)10-1-2-10)8-22-15-9-21-6-5-13(15)16(23)24/h3-7,9-10,22H,1-2,8H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314123
PNG
(3-{[2-cyclopropyl-4-(trifluoromethyl)benzyl]amino}...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1C1CC1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N2O2/c18-17(19,20)12-4-3-11(14(7-12)10-1-2-10)8-22-15-9-21-6-5-13(15)16(23)24/h3-7,9-10,22H,1-2,8H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314127
PNG
(3-{[(4-cyclopropylpyridin-3-yl)-methyl]amino}pyrid...)
Show SMILES OC(=O)c1ccncc1NCc1cnccc1C1CC1
Show InChI InChI=1S/C15H15N3O2/c19-15(20)13-4-6-17-9-14(13)18-8-11-7-16-5-3-12(11)10-1-2-10/h3-7,9-10,18H,1-2,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314129
PNG
(3-[(2-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)16-10-11-20-13-17(16)21-12-14-6-4-5-9-18(14)24-15-7-2-1-3-8-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314130
PNG
(3-[(2-cyclopropyl-5-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1ccc(C2CC2)c(CNc2cnccc2C(O)=O)c1
Show InChI InChI=1S/C17H18N2O2/c1-11-2-5-14(12-3-4-12)13(8-11)9-19-16-10-18-7-6-15(16)17(20)21/h2,5-8,10,12,19H,3-4,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314139
PNG
(3-[(2,3-dihydro-1-benzofuran-2-ylmethyl)amino]pyri...)
Show SMILES OC(=O)c1ccncc1NCC1Cc2ccccc2O1
Show InChI InChI=1S/C15H14N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-6,9,11,17H,7-8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314154
PNG
(3-{[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314128
PNG
(3-{[3-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314128
PNG
(3-{[3-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM50153334
PNG
(CHEMBL3774545 | US10179769, Example 39 | US9611221...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)s1
Show InChI InChI=1S/C12H12N2O2S/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314139
PNG
(3-[(2,3-dihydro-1-benzofuran-2-ylmethyl)amino]pyri...)
Show SMILES OC(=O)c1ccncc1NCC1Cc2ccccc2O1
Show InChI InChI=1S/C15H14N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-6,9,11,17H,7-8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314140
PNG
(3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]p...)
Show SMILES OC(=O)c1ccncc1NCC1COc2ccccc2O1
Show InChI InChI=1S/C15H14N2O4/c18-15(19)11-5-6-16-8-12(11)17-7-10-9-20-13-3-1-2-4-14(13)21-10/h1-6,8,10,17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314140
PNG
(3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]p...)
Show SMILES OC(=O)c1ccncc1NCC1COc2ccccc2O1
Show InChI InChI=1S/C15H14N2O4/c18-15(19)11-5-6-16-8-12(11)17-7-10-9-20-13-3-1-2-4-14(13)21-10/h1-6,8,10,17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314142
PNG
(3-[(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)amino]...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314116
PNG
(3-[(4-chloro-2-methoxybenzyl)amino]pyridine-4-carb...)
Show SMILES COc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O3/c1-20-13-6-10(15)3-2-9(13)7-17-12-8-16-5-4-11(12)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314130
PNG
(3-[(2-cyclopropyl-5-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1ccc(C2CC2)c(CNc2cnccc2C(O)=O)c1
Show InChI InChI=1S/C17H18N2O2/c1-11-2-5-14(12-3-4-12)13(8-11)9-19-16-10-18-7-6-15(16)17(20)21/h2,5-8,10,12,19H,3-4,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314131
PNG
(3-{[3-(trifluoromethoxy)benzyl]amino}pyridine-4-ca...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM50158791
PNG
(CHEMBL3786596 | US10179769, Example 42 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H22N2O2/c20-16(21)14-1-2-18-9-15(14)19-10-17-6-11-3-12(7-17)5-13(4-11)8-17/h1-2,9,11-13,19H,3-8,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314145
PNG
(3-{[(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(F)cc12
Show InChI InChI=1S/C17H17FN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314151
PNG
(3-({[(1S)-5-fluoro-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2c(F)cccc12
Show InChI InChI=1S/C17H17FN2O2/c18-15-6-2-4-12-11(3-1-5-13(12)15)9-20-16-10-19-8-7-14(16)17(21)22/h2,4,6-8,10-11,20H,1,3,5,9H2,(H,21,22)/t11-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314168
PNG
(3-{[(7-cyclopropyl-3,4-dihydro-2H-chromen-4-yl)met...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)C1CC1
Show InChI InChI=1S/C19H20N2O3/c22-19(23)16-5-7-20-11-17(16)21-10-14-6-8-24-18-9-13(12-1-2-12)3-4-15(14)18/h3-5,7,9,11-12,14,21H,1-2,6,8,10H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314178
PNG
(3-({[(4S)-7-cyclopropyl-3,4-dihydro-2H-chromen-4-y...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)C1CC1
Show InChI InChI=1S/C19H20N2O3/c22-19(23)16-5-7-20-11-17(16)21-10-14-6-8-24-18-9-13(12-1-2-12)3-4-15(14)18/h3-5,7,9,11-12,14,21H,1-2,6,8,10H2,(H,22,23)/t14-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314186
PNG
(3-({[(1S)-6-(3,3,3-trifluoropropoxy)-1,2,3,4-tetra...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2cc(OCCC(F)(F)F)ccc12
Show InChI InChI=1S/C20H21F3N2O3/c21-20(22,23)7-9-28-15-4-5-16-13(10-15)2-1-3-14(16)11-25-18-12-24-8-6-17(18)19(26)27/h4-6,8,10,12,14,25H,1-3,7,9,11H2,(H,26,27)/t14-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314129
PNG
(3-[(2-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)16-10-11-20-13-17(16)21-12-14-6-4-5-9-18(14)24-15-7-2-1-3-8-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314134
PNG
(3-[(1-benzofuran-3-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1coc2ccccc12
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-8-13(12)17-7-10-9-20-14-4-2-1-3-11(10)14/h1-6,8-9,17H,7H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314143
PNG
(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]a...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314143
PNG
(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]a...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314143
PNG
(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]a...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314144
PNG
(3-{[(1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES CC1(CNc2cnccc2C(O)=O)CCCc2ccccc12
Show InChI InChI=1S/C18H20N2O2/c1-18(9-4-6-13-5-2-3-7-15(13)18)12-20-16-11-19-10-8-14(16)17(21)22/h2-3,5,7-8,10-11,20H,4,6,9,12H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314157
PNG
(3-({[(6-(propan-2-yloxy)-1,2,3,4-tetrahydronaphtha...)
Show SMILES CC(C)Oc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C20H24N2O3/c1-13(2)25-16-6-7-17-14(10-16)4-3-5-15(17)11-22-19-12-21-9-8-18(19)20(23)24/h6-10,12-13,15,22H,3-5,11H2,1-2H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM360440
PNG
(3-{[(5-fluoro-6-methoxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCOc2c1F
Show InChI InChI=1S/C17H17FN2O4/c1-23-14-3-2-11-10(5-7-24-16(11)15(14)18)8-20-13-9-19-6-4-12(13)17(21)22/h2-4,6,9-10,20H,5,7-8H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314190
PNG
(3-{[(6-{[6-(trifluoromethyl)pyridin-2-yl]oxy}-1,2,...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(Oc3cccc(n3)C(F)(F)F)ccc12
Show InChI InChI=1S/C23H20F3N3O3/c24-23(25,26)20-5-2-6-21(29-20)32-16-7-8-17-14(11-16)3-1-4-15(17)12-28-19-13-27-10-9-18(19)22(30)31/h2,5-11,13,15,28H,1,3-4,12H2,(H,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314123
PNG
(3-{[2-cyclopropyl-4-(trifluoromethyl)benzyl]amino}...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1C1CC1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N2O2/c18-17(19,20)12-4-3-11(14(7-12)10-1-2-10)8-22-15-9-21-6-5-13(15)16(23)24/h3-7,9-10,22H,1-2,8H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314132
PNG
(3-{[2-(phenylamino)benzyl]amino}pyridine-4-carboxy...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c23-19(24)16-10-11-20-13-18(16)21-12-14-6-4-5-9-17(14)22-15-7-2-1-3-8-15/h1-11,13,21-22H,12H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314148
PNG
(3-{[(7-cyclopropyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)C1CC1
Show InChI InChI=1S/C20H22N2O2/c23-20(24)17-8-9-21-12-19(17)22-11-16-3-1-2-14-6-7-15(10-18(14)16)13-4-5-13/h6-10,12-13,16,22H,1-5,11H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314155
PNG
(3-({[(1S)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1...)
Show SMILES COc1ccc2[C@@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314162
PNG
(3-{[(7-phenyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c25-22(26)19-8-10-23-14-20(19)24-13-17-9-11-27-21-12-16(6-7-18(17)21)15-4-2-1-3-5-15/h1-8,10,12,14,17,24H,9,11,13H2,(H,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314172
PNG
(3-({[(6-(3,3,3-trifluoropropoxy)-1,2,3,4-tetrahydr...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OCCC(F)(F)F)ccc12
Show InChI InChI=1S/C20H21F3N2O3/c21-20(22,23)7-9-28-15-4-5-16-13(10-15)2-1-3-14(16)11-25-18-12-24-8-6-17(18)19(26)27/h4-6,8,10,12,14,25H,1-3,7,9,11H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314133
PNG
(3-{[3-(cyclopropylmethoxy)benzyl]amino}pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C17H18N2O3/c20-17(21)15-6-7-18-10-16(15)19-9-13-2-1-3-14(8-13)22-11-12-4-5-12/h1-3,6-8,10,12,19H,4-5,9,11H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314144
PNG
(3-{[(1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES CC1(CNc2cnccc2C(O)=O)CCCc2ccccc12
Show InChI InChI=1S/C18H20N2O2/c1-18(9-4-6-13-5-2-3-7-15(13)18)12-20-16-11-19-10-8-14(16)17(21)22/h2-3,5,7-8,10-11,20H,4,6,9,12H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314146
PNG
(3-{[(7-fluoro-3,4-dihydronaphthalen-1-yl)methyl]am...)
Show SMILES OC(=O)c1ccncc1NCC1=CCCc2ccc(F)cc12
Show InChI InChI=1S/C17H15FN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h3-8,10,20H,1-2,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM360431
PNG
(3-({[6-(2-phenylethoxy)-1,2,3,4-tetrahydronaphthal...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCCc2cc(OCCc3ccccc3)ccc12
Show InChI InChI=1S/C25H26N2O3/c28-25(29)23-11-13-26-17-24(23)27-16-20-8-4-7-19-15-21(9-10-22(19)20)30-14-12-18-5-2-1-3-6-18/h1-3,5-6,9-11,13,15,17,20,27H,4,7-8,12,14,16H2,(H,28,29)/t20-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314180
PNG
(3-({[6-(2,2,2-trifluoroethoxy)-1,2,3,4-tetrahydron...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OCC(F)(F)F)ccc12
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)11-27-14-4-5-15-12(8-14)2-1-3-13(15)9-24-17-10-23-7-6-16(17)18(25)26/h4-8,10,13,24H,1-3,9,11H2,(H,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314105
PNG
(3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314122
PNG
(3-[(4-chloro-2-cyclopropylbenzyl)amino]pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1C1CC1
Show InChI InChI=1S/C16H15ClN2O2/c17-12-4-3-11(14(7-12)10-1-2-10)8-19-15-9-18-6-5-13(15)16(20)21/h3-7,9-10,19H,1-2,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314131
PNG
(3-{[3-(trifluoromethoxy)benzyl]amino}pyridine-4-ca...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314133
PNG
(3-{[3-(cyclopropylmethoxy)benzyl]amino}pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C17H18N2O3/c20-17(21)15-6-7-18-10-16(15)19-9-13-2-1-3-14(8-13)22-11-12-4-5-12/h1-3,6-8,10,12,19H,4-5,9,11H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314149
PNG
(3-{[(5-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2c(F)cccc12
Show InChI InChI=1S/C17H17FN2O2/c18-15-6-2-4-12-11(3-1-5-13(12)15)9-20-16-10-19-8-7-14(16)17(21)22/h2,4,6-8,10-11,20H,1,3,5,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314161
PNG
(3-{[(6-chloro-1-hydroxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(Cl)ccc12
Show InChI InChI=1S/C17H17ClN2O2/c18-13-4-5-14-11(8-13)2-1-3-12(14)9-20-16-10-19-7-6-15(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314158
PNG
(3-{[(6-fluoro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(F)ccc12
Show InChI InChI=1S/C16H15FN2O3/c17-11-1-2-12-10(4-6-22-15(12)7-11)8-19-14-9-18-5-3-13(14)16(20)21/h1-3,5,7,9-10,19H,4,6,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314166
PNG
(3-{[(7-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C23H22N2O2/c26-23(27)20-11-12-24-15-22(20)25-14-19-8-4-7-17-9-10-18(13-21(17)19)16-5-2-1-3-6-16/h1-3,5-6,9-13,15,19,25H,4,7-8,14H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314171
PNG
(3-[(3,4-dihydro-2H-thiochromen-4-ylmethyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCSc2ccccc12
Show InChI InChI=1S/C16H16N2O2S/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314181
PNG
(3-({[7-(2-cyclopropylethyl)-3,4-dihydro-2H-chromen...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(CCC3CC3)ccc12
Show InChI InChI=1S/C21H24N2O3/c24-21(25)18-7-9-22-13-19(18)23-12-16-8-10-26-20-11-15(5-6-17(16)20)4-3-14-1-2-14/h5-7,9,11,13-14,16,23H,1-4,8,10,12H2,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314131
PNG
(3-{[3-(trifluoromethoxy)benzyl]amino}pyridine-4-ca...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50158791
PNG
(CHEMBL3786596 | US10179769, Example 42 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H22N2O2/c20-16(21)14-1-2-18-9-15(14)19-10-17-6-11-3-12(7-17)5-13(4-11)8-17/h1-2,9,11-13,19H,3-8,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314150
PNG
(3-{[(5-fluoro-1-hydroxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES OC(=O)c1ccncc1NCC1(O)CCCc2c(F)cccc12
Show InChI InChI=1S/C17H17FN2O3/c18-14-5-1-4-13-11(14)3-2-7-17(13,23)10-20-15-9-19-8-6-12(15)16(21)22/h1,4-6,8-9,20,23H,2-3,7,10H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314154
PNG
(3-{[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314159
PNG
(3-{[(7-chloro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(Cl)ccc12
Show InChI InChI=1S/C16H15ClN2O3/c17-11-1-2-12-10(4-6-22-15(12)7-11)8-19-14-9-18-5-3-13(14)16(20)21/h1-3,5,7,9-10,19H,4,6,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314175
PNG
(3{[(1-methyl-1,2,3,4-tetrahydroquinolin-4-yl)methy...)
Show SMILES CN1CCC(CNc2cnccc2C(O)=O)c2ccccc12
Show InChI InChI=1S/C17H19N3O2/c1-20-9-7-12(13-4-2-3-5-16(13)20)10-19-15-11-18-8-6-14(15)17(21)22/h2-6,8,11-12,19H,7,9-10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314176
PNG
(3-({[(4S)-7-phenyl-3,4-dihydro-2H-chromen-4-yl]met...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c25-22(26)19-8-10-23-14-20(19)24-13-17-9-11-27-21-12-16(6-7-18(17)21)15-4-2-1-3-5-15/h1-8,10,12,14,17,24H,9,11,13H2,(H,25,26)/t17-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314189
PNG
(3-{[(5,6-dimethyl-1,2,3,4-tetrahydronaphthalen-1-y...)
Show SMILES Cc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1C
Show InChI InChI=1S/C19H22N2O2/c1-12-6-7-16-14(4-3-5-15(16)13(12)2)10-21-18-11-20-9-8-17(18)19(22)23/h6-9,11,14,21H,3-5,10H2,1-2H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314121
PNG
(3-[(4-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-11-1-3-12(4-2-11)13-5-6-13/h1-4,7-8,10,13,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314144
PNG
(3-{[(1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES CC1(CNc2cnccc2C(O)=O)CCCc2ccccc12
Show InChI InChI=1S/C18H20N2O2/c1-18(9-4-6-13-5-2-3-7-15(13)18)12-20-16-11-19-10-8-14(16)17(21)22/h2-3,5,7-8,10-11,20H,4,6,9,12H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314165
PNG
(3-{[(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(Cl)cc12
Show InChI InChI=1S/C17H17ClN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314167
PNG
(3-{[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1cccc2C(CNc3cnccc3C(O)=O)CCCc12
Show InChI InChI=1S/C18H20N2O3/c1-23-17-7-3-5-13-12(4-2-6-14(13)17)10-20-16-11-19-9-8-15(16)18(21)22/h3,5,7-9,11-12,20H,2,4,6,10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314142
PNG
(3-[(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)amino]...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314153
PNG
(3-{[(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-y...)
Show SMILES CC1(C)CCC(CNc2cnccc2C(O)=O)c2ccccc12
Show InChI InChI=1S/C19H22N2O2/c1-19(2)9-7-13(14-5-3-4-6-16(14)19)11-21-17-12-20-10-8-15(17)18(22)23/h3-6,8,10,12-13,21H,7,9,11H2,1-2H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314156
PNG
(3-{[(6-methyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES Cc1ccc2OCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-11-2-3-16-14(8-11)12(5-7-22-16)9-19-15-10-18-6-4-13(15)17(20)21/h2-4,6,8,10,12,19H,5,7,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314160
PNG
(3-{[(6-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1(O)CCCc2cc(Cl)ccc12
Show InChI InChI=1S/C17H17ClN2O3/c18-12-3-4-14-11(8-12)2-1-6-17(14,23)10-20-15-9-19-7-5-13(15)16(21)22/h3-5,7-9,20,23H,1-2,6,10H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50158790
PNG
(CHEMBL3787556 | US10179769, Example 80 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C23H22N2O3/c26-23(27)21-11-12-24-15-22(21)25-14-17-6-4-5-16-13-19(9-10-20(16)17)28-18-7-2-1-3-8-18/h1-3,7-13,15,17,25H,4-6,14H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314174
PNG
(3-({[(6-(cyclopropylmethoxy)-1,2,3,4-tetrahydronap...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OCC3CC3)ccc12
Show InChI InChI=1S/C21H24N2O3/c24-21(25)19-8-9-22-12-20(19)23-11-16-3-1-2-15-10-17(6-7-18(15)16)26-13-14-4-5-14/h6-10,12,14,16,23H,1-5,11,13H2,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314187
PNG
(3-({[6-(3,3,3-trifluoropropoxy)-1,2,3,4-tetrahydro...)
Show SMILES OC(=O)c1ccnnc1NCC1CCCc2cc(OCCC(F)(F)F)ccc12
Show InChI InChI=1S/C19H20F3N3O3/c20-19(21,22)7-9-28-14-4-5-15-12(10-14)2-1-3-13(15)11-23-17-16(18(26)27)6-8-24-25-17/h4-6,8,10,13H,1-3,7,9,11H2,(H,23,25)(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314183
PNG
(3-({[(4S)-7-(4-fluorophenyl)-3,4-dihydro-2H-chrome...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN2O3/c23-17-4-1-14(2-5-17)15-3-6-18-16(8-10-28-21(18)11-15)12-25-20-13-24-9-7-19(20)22(26)27/h1-7,9,11,13,16,25H,8,10,12H2,(H,26,27)/t16-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314169
PNG
(3-({[(5-(cyclopropylmethoxy)-1,2,3,4-tetrahydronap...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2c(OCC3CC3)cccc12
Show InChI InChI=1S/C21H24N2O3/c24-21(25)18-9-10-22-12-19(18)23-11-15-3-1-5-17-16(15)4-2-6-20(17)26-13-14-7-8-14/h2,4,6,9-10,12,14-15,23H,1,3,5,7-8,11,13H2,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314147
PNG
(3-{[(5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-y...)
Show SMILES Cc1cc(C)c2CCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C19H22N2O2/c1-12-8-13(2)15-5-3-4-14(17(15)9-12)10-21-18-11-20-7-6-16(18)19(22)23/h6-9,11,14,21H,3-5,10H2,1-2H3,(H,22,23)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314182
PNG
(3-({[6-(trifluoromethoxy)-1,2,3,4-tetrahydronaphth...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OC(F)(F)F)ccc12
Show InChI InChI=1S/C18H17F3N2O3/c19-18(20,21)26-13-4-5-14-11(8-13)2-1-3-12(14)9-23-16-10-22-7-6-15(16)17(24)25/h4-8,10,12,23H,1-3,9H2,(H,24,25)
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314177
PNG
(3-({[(4S)-7-(3-fluorophenyl)-3,4-dihydro-2H-chrome...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1cccc(F)c1
Show InChI InChI=1S/C22H19FN2O3/c23-17-3-1-2-14(10-17)15-4-5-18-16(7-9-28-21(18)11-15)12-25-20-13-24-8-6-19(20)22(26)27/h1-6,8,10-11,13,16,25H,7,9,12H2,(H,26,27)/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314184
PNG
(3-({[(4S)-7-(2-fluorophenyl)-3,4-dihydro-2H- chrom...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccccc1F
Show InChI InChI=1S/C22H19FN2O3/c23-19-4-2-1-3-16(19)14-5-6-17-15(8-10-28-21(17)11-14)12-25-20-13-24-9-7-18(20)22(26)27/h1-7,9,11,13,15,25H,8,10,12H2,(H,26,27)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314105
PNG
(3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314170
PNG
(3-{[(5-phenoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2c(Oc3ccccc3)cccc12
Show InChI InChI=1S/C23H22N2O3/c26-23(27)20-12-13-24-15-21(20)25-14-16-6-4-10-19-18(16)9-5-11-22(19)28-17-7-2-1-3-8-17/h1-3,5,7-9,11-13,15-16,25H,4,6,10,14H2,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314185
PNG
(3-({[(1S)-6-(2-cyclopropylethoxy)-1,2,3,4-tetrahyd...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2cc(OCCC3CC3)ccc12
Show InChI InChI=1S/C22H26N2O3/c25-22(26)20-8-10-23-14-21(20)24-13-17-3-1-2-16-12-18(6-7-19(16)17)27-11-9-15-4-5-15/h6-8,10,12,14-15,17,24H,1-5,9,11,13H2,(H,25,26)/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...


US Patent US9828343 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%