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Patent code US9828369

Compile Data Set for Download or QSAR
Found 167 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360442
PNG
(US9828369, Example 14 | ethyl 3-(8-((2- phenylcycl...)
Show SMILES CCOC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C29H26N2O3/c1-2-34-29(33)21-10-6-9-20(15-21)23-12-11-22(27-18-30-14-13-24(23)27)17-31-28(32)26-16-25(26)19-7-4-3-5-8-19/h3-15,18,25-26H,2,16-17H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360342
PNG
(US9828369, Example 3 | methyl 3-(8-(((1R,2R)-2- ph...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H24N2O3/c1-33-28(32)20-9-5-8-19(14-20)22-11-10-21(26-17-29-13-12-23(22)26)16-30-27(31)25-15-24(25)18-6-3-2-4-7-18/h2-14,17,24-25H,15-16H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360337
PNG
(US9828369, Example 2 | methyl 3-(8-((2-(4-(trifluo...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C27H21F3N2O3/c1-35-26(34)19-4-2-3-18(14-19)22-10-7-20(24-16-31-12-11-23(22)24)15-32-25(33)13-17-5-8-21(9-6-17)27(28,29)30/h2-12,14,16H,13,15H2,1H3,(H,32,33)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360343
PNG
(US9828369, Example 4 | methyl 3-(8-((2-(3-methyl-1...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2nc(C)no2)c2cnccc12
Show InChI InChI=1S/C25H22N4O4/c1-14-28-24(33-29-14)21-11-20(21)23(30)27-12-17-6-7-18(19-8-9-26-13-22(17)19)15-4-3-5-16(10-15)25(31)32-2/h3-10,13,20-21H,11-12H2,1-2H3,(H,27,30)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360348
PNG
(US9828369, Example 5 | methyl 3-(8-((1-(4-(trifluo...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CCN(CC2)c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C31H28F3N3O3/c1-40-30(39)22-4-2-3-21(17-22)26-10-5-23(28-19-35-14-11-27(26)28)18-36-29(38)20-12-15-37(16-13-20)25-8-6-24(7-9-25)31(32,33)34/h2-11,14,17,19-20H,12-13,15-16,18H2,1H3,(H,36,38)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360433
PNG
(US9828369, Example 6 | methyl 3-(8-((2-(4-phenoxyp...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C32H26N2O4/c1-37-32(36)24-7-5-6-23(19-24)28-15-12-25(30-21-33-17-16-29(28)30)20-34-31(35)18-22-10-13-27(14-11-22)38-26-8-3-2-4-9-26/h2-17,19,21H,18,20H2,1H3,(H,34,35)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360434
PNG
(US9828369, Example 7 | methyl 3-(8-((3-(tert-butyl...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2cc(nn2C)C(C)(C)C)c2cnccc12
Show InChI InChI=1S/C27H28N4O3/c1-27(2,3)24-14-23(31(4)30-24)25(32)29-15-19-9-10-20(21-11-12-28-16-22(19)21)17-7-6-8-18(13-17)26(33)34-5/h6-14,16H,15H2,1-5H3,(H,29,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360444
PNG
(N-((5-(3-ethoxyphenyl)isoquinolin- 8-yl)methyl)-2-...)
Show SMILES CCOc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H26N2O2/c1-2-32-22-10-6-9-20(15-22)23-12-11-21(27-18-29-14-13-24(23)27)17-30-28(31)26-16-25(26)19-7-4-3-5-8-19/h3-15,18,25-26H,2,16-17H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360600
PNG
(1-([1,1'-biphenyl]-3-yl)-3-((5(3- methoxyphenyl)is...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Nc2cccc(c2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C30H25N3O2/c1-35-26-12-6-10-23(18-26)27-14-13-24(29-20-31-16-15-28(27)29)19-32-30(34)33-25-11-5-9-22(17-25)21-7-3-2-4-8-21/h2-18,20H,19H2,1H3,(H2,32,33,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360585
PNG
((R/S)-2-(6-methoxynaphthalen-2-yl)- N-((5-(3-metho...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H](C)c2ccc3cc(OC)ccc3c2)c2cnccc12
Show InChI InChI=1S/C31H28N2O3/c1-20(21-7-8-23-16-27(36-3)11-9-22(23)15-21)31(34)33-18-25-10-12-28(29-13-14-32-19-30(25)29)24-5-4-6-26(17-24)35-2/h4-17,19-20H,18H2,1-3H3,(H,33,34)/t20-/m1/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360435
PNG
(US9828369, Example 8 | methyl 3-(8-((1-phenyl-5- (...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2cnn(c2C(F)(F)F)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C29H21F3N4O3/c1-39-28(38)19-7-5-6-18(14-19)22-11-10-20(24-16-33-13-12-23(22)24)15-34-27(37)25-17-35-36(26(25)29(30,31)32)21-8-3-2-4-9-21/h2-14,16-17H,15H2,1H3,(H,34,37)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360436
PNG
(US9828369, Example 9 | methyl 3-(8-((1-methyl-3-pr...)
Show SMILES CCCc1cc(C(=O)NCc2ccc(-c3cccc(c3)C(=O)OC)c3ccncc23)n(C)n1
Show InChI InChI=1S/C26H26N4O3/c1-4-6-20-14-24(30(2)29-20)25(31)28-15-19-9-10-21(22-11-12-27-16-23(19)22)17-7-5-8-18(13-17)26(32)33-3/h5,7-14,16H,4,6,15H2,1-3H3,(H,28,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360437
PNG
(US9828369, Example 10 | methyl 3-(8-((spiro[2.4]he...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC22CCCC2)c2cnccc12
Show InChI InChI=1S/C26H26N2O3/c1-31-25(30)18-6-4-5-17(13-18)20-8-7-19(22-16-27-12-9-21(20)22)15-28-24(29)23-14-26(23)10-2-3-11-26/h4-9,12-13,16,23H,2-3,10-11,14-15H2,1H3,(H,28,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360438
PNG
(8-((isoquinoline-1- carboxamido)methyl)-5-(3- (met...)
Show SMILES OCC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2nccc3ccccc23)c2cnccc12
Show InChI InChI=1S/C28H21N3O3/c32-17-26(33)20-6-3-5-19(14-20)22-9-8-21(25-16-29-12-11-24(22)25)15-31-28(34)27-23-7-2-1-4-18(23)10-13-30-27/h1-14,16,32H,15,17H2,(H,31,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360545
PNG
(2-(4-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccc(F)cc2)c2cnccc12
Show InChI InChI=1S/C27H23FN2O2/c1-32-21-4-2-3-18(13-21)22-10-7-19(26-16-29-12-11-23(22)26)15-30-27(31)25-14-24(25)17-5-8-20(28)9-6-17/h2-13,16,24-25H,14-15H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360439
PNG
(8-((isoquinoline-5- carboxamido)methyl)-5-(3- (me...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2cccc3cnccc23)c2cnccc12
Show InChI InChI=1S/C28H21N3O3/c1-34-28(33)19-5-2-4-18(14-19)22-9-8-21(26-17-30-13-11-24(22)26)16-31-27(32)25-7-3-6-20-15-29-12-10-23(20)25/h2-15,17H,16H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360586
PNG
(2-(6-methoxynaphthalen-2-yl)-N-((5- (3-methoxyphen...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccc3cc(OC)ccc3c2)c2cnccc12
Show InChI InChI=1S/C31H28N2O3/c1-20(21-7-8-23-16-27(36-3)11-9-22(23)15-21)31(34)33-18-25-10-12-28(29-13-14-32-19-30(25)29)24-5-4-6-26(17-24)35-2/h4-17,19-20H,18H2,1-3H3,(H,33,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360595
PNG
(1-(2,3-dichlorophenyl)-3-((5-(3,5- dimethoxyphenyl...)
Show SMILES COc1cc(OC)cc(c1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C25H21Cl2N3O3/c1-32-17-10-16(11-18(12-17)33-2)19-7-6-15(21-14-28-9-8-20(19)21)13-29-25(31)30-23-5-3-4-22(26)24(23)27/h3-12,14H,13H2,1-2H3,(H2,29,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360613
PNG
(US9828369, Example 172)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C28H25NO2/c1-31-22-11-7-10-20(16-22)24-15-14-21(23-12-5-6-13-25(23)24)18-29-28(30)27-17-26(27)19-8-3-2-4-9-19/h2-16,26-27H,17-18H2,1H3,(H,29,30)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360582
PNG
(2-(2-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccccc2F)c2cnccc12
Show InChI InChI=1S/C26H23FN2O2/c1-17(21-8-3-4-9-25(21)27)26(30)29-15-19-10-11-22(23-12-13-28-16-24(19)23)18-6-5-7-20(14-18)31-2/h3-14,16-17H,15H2,1-2H3,(H,29,30)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360542
PNG
(2-(3-bromophenyl)-N-((5-(3- methoxyphenyl)isoquino...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccc(Br)cc2)c2cnccc12
Show InChI InChI=1S/C27H23BrN2O2/c1-32-21-4-2-3-18(13-21)22-10-7-19(26-16-29-12-11-23(22)26)15-30-27(31)25-14-24(25)17-5-8-20(28)9-6-17/h2-13,16,24-25H,14-15H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360543
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC22CCCCC2)c2cnccc12
Show InChI InChI=1S/C26H28N2O2/c1-30-20-7-5-6-18(14-20)21-9-8-19(23-17-27-13-10-22(21)23)16-28-25(29)24-15-26(24)11-3-2-4-12-26/h5-10,13-14,17,24H,2-4,11-12,15-16H2,1H3,(H,28,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360579
PNG
(2-(4-cyanophenyl)-N-((5-(3- methoxyphenyl)isoquino...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccc(cc2)C#N)c2cnccc12
Show InChI InChI=1S/C27H23N3O2/c1-18(20-8-6-19(15-28)7-9-20)27(31)30-16-22-10-11-24(25-12-13-29-17-26(22)25)21-4-3-5-23(14-21)32-2/h3-14,17-18H,16H2,1-2H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360573
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)bi...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C]234CC2(C3)C4)c2cnccc12
Show InChI InChI=1S/C23H21N2O2/c1-27-17-4-2-3-15(9-17)18-6-5-16(20-11-24-8-7-19(18)20)10-25-21(26)23-12-22(23,13-23)14-23/h2-9,11H,10,12-14H2,1H3,(H,25,26)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360447
PNG
(N-((5-(3- (methoxymethyl)phenyl)isoquinolin- 8-yl)...)
Show SMILES COCc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H26N2O2/c1-32-18-19-6-5-9-21(14-19)23-11-10-22(27-17-29-13-12-24(23)27)16-30-28(31)26-15-25(26)20-7-3-2-4-8-20/h2-14,17,25-26H,15-16,18H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360489
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(c2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C26H21F3N2O2/c1-33-21-7-3-5-18(14-21)22-9-8-19(24-16-30-11-10-23(22)24)15-31-25(32)13-17-4-2-6-20(12-17)26(27,28)29/h2-12,14,16H,13,15H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360581
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H24N2O2/c1-18(19-7-4-3-5-8-19)26(29)28-16-21-11-12-23(24-13-14-27-17-25(21)24)20-9-6-10-22(15-20)30-2/h3-15,17-18H,16H2,1-2H3,(H,28,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360537
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)CCc2cnn(C)c2)c2cnccc12
Show InChI InChI=1S/C24H24N4O2/c1-28-16-17(13-27-28)6-9-24(29)26-14-19-7-8-21(22-10-11-25-15-23(19)22)18-4-3-5-20(12-18)30-2/h3-5,7-8,10-13,15-16H,6,9,14H2,1-2H3,(H,26,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360498
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccccc2Oc2ccccc2)c2cnccc12
Show InChI InChI=1S/C31H26N2O3/c1-35-26-12-7-9-22(18-26)27-15-14-24(29-21-32-17-16-28(27)29)20-33-31(34)19-23-8-5-6-13-30(23)36-25-10-3-2-4-11-25/h2-18,21H,19-20H2,1H3,(H,33,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360484
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C26H21F3N2O2/c1-33-21-4-2-3-18(14-21)22-10-7-19(24-16-30-12-11-23(22)24)15-31-25(32)13-17-5-8-20(9-6-17)26(27,28)29/h2-12,14,16H,13,15H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360588
PNG
((R/S)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)- N-((5-(3-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H](C)c2ccc(c(F)c2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C32H27FN2O2/c1-21(23-11-14-28(31(33)18-23)22-7-4-3-5-8-22)32(36)35-19-25-12-13-27(29-15-16-34-20-30(25)29)24-9-6-10-26(17-24)37-2/h3-18,20-21H,19H2,1-2H3,(H,35,36)/t21-/m1/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360577
PNG
(2-([1,1'-biphenyl]-4-yl)-N-((5-(3- methoxyphenyl)i...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccc(cc2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C32H28N2O2/c1-22(23-11-13-25(14-12-23)24-7-4-3-5-8-24)32(35)34-20-27-15-16-29(30-17-18-33-21-31(27)30)26-9-6-10-28(19-26)36-2/h3-19,21-22H,20H2,1-2H3,(H,34,35)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360569
PNG
((R/S)-2-(3-fluoro-4- (trifluoromethyl)phenyl)-N-((...)
Show SMILES CC[C@H](C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C28H24F4N2O2/c1-3-21(18-8-10-25(26(29)14-18)28(30,31)32)27(35)34-15-19-7-9-22(23-11-12-33-16-24(19)23)17-5-4-6-20(13-17)36-2/h4-14,16,21H,3,15H2,1-2H3,(H,34,35)/t21-/m0/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360601
PNG
(1-(2,3-dichlorophenyl)-3-((5-(1- phenylyinyl)isoqu...)
Show SMILES Clc1cccc(NC(=O)NCc2ccc(C(=C)c3ccccc3)c3ccncc23)c1Cl
Show InChI InChI=1S/C25H19Cl2N3O/c1-16(17-6-3-2-4-7-17)19-11-10-18(21-15-28-13-12-20(19)21)14-29-25(31)30-23-9-5-8-22(26)24(23)27/h2-13,15H,1,14H2,(H2,29,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360574
PNG
(5-bromo-2-fluoro-N-((5-(3- methoxyphenyl)isoquinol...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(Br)cnc2F)c2cnccc12
Show InChI InChI=1S/C23H17BrFN3O2/c1-30-17-4-2-3-14(9-17)18-6-5-15(21-13-26-8-7-19(18)21)11-28-23(29)20-10-16(24)12-27-22(20)25/h2-10,12-13H,11H2,1H3,(H,28,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360593
PNG
(N-((5-(3-methoxyphenyl)quinolin- 8-yl)methyl)-2-(4...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(cc2)C(F)(F)F)c2ncccc12
Show InChI InChI=1S/C26H21F3N2O2/c1-33-21-5-2-4-18(15-21)22-12-9-19(25-23(22)6-3-13-30-25)16-31-24(32)14-17-7-10-20(11-8-17)26(27,28)29/h2-13,15H,14,16H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360602
PNG
(1-(2,3-dichlorophenyl)-3-((5-(3- methoxypropyl)iso...)
Show SMILES COCCCc1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C21H21Cl2N3O2/c1-28-11-3-4-14-7-8-15(17-13-24-10-9-16(14)17)12-25-21(27)26-19-6-2-5-18(22)20(19)23/h2,5-10,13H,3-4,11-12H2,1H3,(H2,25,26,27)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360509
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cn(nc2-c2ccccc2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C33H26N4O2/c1-39-27-14-8-11-24(19-27)28-16-15-25(30-21-34-18-17-29(28)30)20-35-33(38)31-22-37(26-12-6-3-7-13-26)36-32(31)23-9-4-2-5-10-23/h2-19,21-22H,20H2,1H3,(H,35,38)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360524
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2nnc([nH]2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H23N5O2/c1-34-21-9-5-8-19(14-21)22-11-10-20(24-17-28-13-12-23(22)24)16-29-26(33)15-25-30-27(32-31-25)18-6-3-2-4-7-18/h2-14,17H,15-16H2,1H3,(H,29,33)(H,30,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360547
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2cccnc2)c2cnccc12
Show InChI InChI=1S/C26H23N3O2/c1-31-20-6-2-4-17(12-20)21-8-7-19(25-16-28-11-9-22(21)25)15-29-26(30)24-13-23(24)18-5-3-10-27-14-18/h2-12,14,16,23-24H,13,15H2,1H3,(H,29,30)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360580
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccc(OC(F)(F)F)cc2)c2cnccc12
Show InChI InChI=1S/C27H23F3N2O3/c1-17(18-6-9-21(10-7-18)35-27(28,29)30)26(33)32-15-20-8-11-23(24-12-13-31-16-25(20)24)19-4-3-5-22(14-19)34-2/h3-14,16-17H,15H2,1-2H3,(H,32,33)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360566
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2(CCC2)c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C29H25F3N2O2/c1-36-23-5-2-4-19(16-23)24-11-6-20(26-18-33-15-12-25(24)26)17-34-27(35)28(13-3-14-28)21-7-9-22(10-8-21)29(30,31)32/h2,4-12,15-16,18H,3,13-14,17H2,1H3,(H,34,35)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360451
PNG
((1S,2S)-2-(4-methoxyphenyl)-N-((5- (3-methoxypheny...)
Show SMILES COc1ccc(cc1)C1CC1C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12
Show InChI InChI=1S/C28H26N2O3/c1-32-21-9-6-18(7-10-21)25-15-26(25)28(31)30-16-20-8-11-23(24-12-13-29-17-27(20)24)19-4-3-5-22(14-19)33-2/h3-14,17,25-26H,15-16H2,1-2H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360553
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-4...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2n[nH]c(=O)c3ccccc23)c2cnccc12
Show InChI InChI=1S/C26H20N4O3/c1-33-18-6-4-5-16(13-18)19-10-9-17(23-15-27-12-11-20(19)23)14-28-26(32)24-21-7-2-3-8-22(21)25(31)30-29-24/h2-13,15H,14H2,1H3,(H,28,32)(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360502
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cc(F)c(F)cc2F)c2cnccc12
Show InChI InChI=1S/C25H19F3N2O2/c1-32-18-4-2-3-15(9-18)19-6-5-16(21-14-29-8-7-20(19)21)13-30-25(31)11-17-10-23(27)24(28)12-22(17)26/h2-10,12,14H,11,13H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360584
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C27H23F3N2O2/c1-17(18-6-9-21(10-7-18)27(28,29)30)26(33)32-15-20-8-11-23(24-12-13-31-16-25(20)24)19-4-3-5-22(14-19)34-2/h3-14,16-17H,15H2,1-2H3,(H,32,33)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360576
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccnc(c2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C24H18F3N3O2/c1-32-18-4-2-3-15(11-18)19-6-5-17(21-14-28-9-8-20(19)21)13-30-23(31)16-7-10-29-22(12-16)24(25,26)27/h2-12,14H,13H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360452
PNG
((cis)-2-(4-methoxyphenyl)-N-((5-(3- methoxyphenyl)...)
Show SMILES COc1ccc(cc1)[C@@H]1C[C@@H]1C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12
Show InChI InChI=1S/C28H26N2O3/c1-32-21-9-6-18(7-10-21)25-15-26(25)28(31)30-16-20-8-11-23(24-12-13-29-17-27(20)24)19-4-3-5-22(14-19)33-2/h3-14,17,25-26H,15-16H2,1-2H3,(H,30,31)/t25-,26-/m0/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360551
PNG
((trans)-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H]2CC2c2nc(C)no2)c2cnccc12
Show InChI InChI=1S/C24H22N4O3/c1-14-27-24(31-28-14)21-11-20(21)23(29)26-12-16-6-7-18(19-8-9-25-13-22(16)19)15-4-3-5-17(10-15)30-2/h3-10,13,20-21H,11-12H2,1-2H3,(H,26,29)/t20-,21?/m0/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360540
PNG
(2-(4-chlorophenyl)-N-((5-(3 methoxyphenyl)isoquino...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccc(Cl)cc2)c2cnccc12
Show InChI InChI=1S/C27H23ClN2O2/c1-32-21-4-2-3-18(13-21)22-10-7-19(26-16-29-12-11-23(22)26)15-30-27(31)25-14-24(25)17-5-8-20(28)9-6-17/h2-13,16,24-25H,14-15H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360505
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(OC(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C26H21F3N2O3/c1-33-20-6-3-5-18(14-20)22-9-8-19(24-16-30-11-10-23(22)24)15-31-25(32)13-17-4-2-7-21(12-17)34-26(27,28)29/h2-12,14,16H,13,15H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360525
PNG
(2'-hydroxy-N-((5-(3- methoxyphenyl)isoquinolin-8-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc(cc2)-c2ccccc2O)c2cnccc12
Show InChI InChI=1S/C30H24N2O3/c1-35-24-6-4-5-22(17-24)25-14-13-23(28-19-31-16-15-27(25)28)18-32-30(34)21-11-9-20(10-12-21)26-7-2-3-8-29(26)33/h2-17,19,33H,18H2,1H3,(H,32,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360507
PNG
(2-(2-(4-fluorophenyl)thiazol-4-yl)-N- ((5-(3-metho...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2csc(n2)-c2ccc(F)cc2)c2cnccc12
Show InChI InChI=1S/C28H22FN3O2S/c1-34-23-4-2-3-19(13-23)24-10-7-20(26-16-30-12-11-25(24)26)15-31-27(33)14-22-17-35-28(32-22)18-5-8-21(29)9-6-18/h2-13,16-17H,14-15H2,1H3,(H,31,33)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360583
PNG
((R/S)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)- N-((5-(3-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H](C)c2ccc(c(F)c2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C32H27FN2O2/c1-21(23-11-14-28(31(33)18-23)22-7-4-3-5-8-22)32(36)35-19-25-12-13-27(29-15-16-34-20-30(25)29)24-9-6-10-26(17-24)37-2/h3-18,20-21H,19H2,1-2H3,(H,35,36)/t21-/m0/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360552
PNG
(2-fluoro-N-((5-(3- methoxyphenyl)isoquinolin-8- yl...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2(F)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H23FN2O2/c1-32-21-9-5-6-18(14-21)22-11-10-19(24-17-29-13-12-23(22)24)16-30-26(31)25-15-27(25,28)20-7-3-2-4-8-20/h2-14,17,25H,15-16H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360472
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)qu...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cccc3ncccc23)c2cnccc12
Show InChI InChI=1S/C27H21N3O2/c1-32-20-6-2-5-18(15-20)21-11-10-19(25-17-28-14-12-22(21)25)16-30-27(31)24-7-3-9-26-23(24)8-4-13-29-26/h2-15,17H,16H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360504
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccccc2OC(F)(F)F)c2cnccc12
Show InChI InChI=1S/C26H21F3N2O3/c1-33-20-7-4-6-17(13-20)21-10-9-19(23-16-30-12-11-22(21)23)15-31-25(32)14-18-5-2-3-8-24(18)34-26(27,28)29/h2-13,16H,14-15H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360457
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)CCc2nc(no2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H24N4O3/c1-34-22-9-5-8-20(16-22)23-11-10-21(25-18-29-15-14-24(23)25)17-30-26(33)12-13-27-31-28(32-35-27)19-6-3-2-4-7-19/h2-11,14-16,18H,12-13,17H2,1H3,(H,30,33)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360458
PNG
(2-(2,3-dichlorophenyl)-N-((5-(3- methoxyphenyl)iso...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C25H20Cl2N2O2/c1-31-19-6-2-4-16(12-19)20-9-8-18(22-15-28-11-10-21(20)22)14-29-24(30)13-17-5-3-7-23(26)25(17)27/h2-12,15H,13-14H2,1H3,(H,29,30)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360448
PNG
(N-((5-(3- isopropoxyphenyl)isoquinolin-8- yl)methy...)
Show SMILES CC(C)Oc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C29H28N2O2/c1-19(2)33-23-10-6-9-21(15-23)24-12-11-22(28-18-30-14-13-25(24)28)17-31-29(32)27-16-26(27)20-7-4-3-5-8-20/h3-15,18-19,26-27H,16-17H2,1-2H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360534
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cccc(c2)-n2cnnn2)c2cnccc12
Show InChI InChI=1S/C25H20N6O2/c1-33-21-7-3-4-17(13-21)22-9-8-19(24-15-26-11-10-23(22)24)14-27-25(32)18-5-2-6-20(12-18)31-16-28-29-30-31/h2-13,15-16H,14H2,1H3,(H,27,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360533
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccccc2-n2cnnn2)c2cnccc12
Show InChI InChI=1S/C25H20N6O2/c1-33-19-6-4-5-17(13-19)20-10-9-18(23-15-26-12-11-21(20)23)14-27-25(32)22-7-2-3-8-24(22)31-16-28-29-30-31/h2-13,15-16H,14H2,1H3,(H,27,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360544
PNG
(2-(2-bromophenyl)-N-((5-(3- methoxyphenyl)isoquino...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2Br)c2cnccc12
Show InChI InChI=1S/C27H23BrN2O2/c1-32-19-6-4-5-17(13-19)20-10-9-18(25-16-29-12-11-21(20)25)15-30-27(31)24-14-23(24)22-7-2-3-8-26(22)28/h2-13,16,23-24H,14-15H2,1H3,(H,30,31)
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n/an/a 915n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360589
PNG
((R/S)-2-(4-isobutylphenyl)-N-((5-(3- methoxyphenyl...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H](C)c2ccc(CC(C)C)cc2)c2cnccc12
Show InChI InChI=1S/C30H32N2O2/c1-20(2)16-22-8-10-23(11-9-22)21(3)30(33)32-18-25-12-13-27(28-14-15-31-19-29(25)28)24-6-5-7-26(17-24)34-4/h5-15,17,19-21H,16,18H2,1-4H3,(H,32,33)/t21-/m1/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360594
PNG
(US9828369, Example 151)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Nc2ccc(OC(F)(F)F)cc2)c2cnccc12
Show InChI InChI=1S/C25H20F3N3O3/c1-33-20-4-2-3-16(13-20)21-10-5-17(23-15-29-12-11-22(21)23)14-30-24(32)31-18-6-8-19(9-7-18)34-25(26,27)28/h2-13,15H,14H2,1H3,(H2,30,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360560
PNG
(1-benzyl-N-((5-(3- methoxyphenyl)isoquinolin-8- yl...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(C)n(Cc3ccccc3)n2)c2cnccc12
Show InChI InChI=1S/C29H26N4O2/c1-20-15-28(32-33(20)19-21-7-4-3-5-8-21)29(34)31-17-23-11-12-25(26-13-14-30-18-27(23)26)22-9-6-10-24(16-22)35-2/h3-16,18H,17,19H2,1-2H3,(H,31,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360571
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CCN(CC2)c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C30H28F3N3O2/c1-38-25-4-2-3-21(17-25)26-10-5-22(28-19-34-14-11-27(26)28)18-35-29(37)20-12-15-36(16-13-20)24-8-6-23(7-9-24)30(31,32)33/h2-11,14,17,19-20H,12-13,15-16,18H2,1H3,(H,35,37)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360592
PNG
((R/S)-2-(3,5- bis(trifluoromethyl)phenyl)-N-((5-(3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H](C)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C28H22F6N2O2/c1-16(19-10-20(27(29,30)31)13-21(11-19)28(32,33)34)26(37)36-14-18-6-7-23(24-8-9-35-15-25(18)24)17-4-3-5-22(12-17)38-2/h3-13,15-16H,14H2,1-2H3,(H,36,37)/t16-/m0/s1
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360527
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-4...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc(cc2)N2CCCCC2)c2cnccc12
Show InChI InChI=1S/C29H29N3O2/c1-34-25-7-5-6-22(18-25)26-13-10-23(28-20-30-15-14-27(26)28)19-31-29(33)21-8-11-24(12-9-21)32-16-3-2-4-17-32/h5-15,18,20H,2-4,16-17,19H2,1H3,(H,31,33)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360490
PNG
(2-(2-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccccc2F)c2cnccc12
Show InChI InChI=1S/C25H21FN2O2/c1-30-20-7-4-6-17(13-20)21-10-9-19(23-16-27-12-11-22(21)23)15-28-25(29)14-18-5-2-3-8-24(18)26/h2-13,16H,14-15H2,1H3,(H,28,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360596
PNG
(US9828369, Example 153 | methyl 2-(3-((5-(3- metho...)
Show SMILES COC(=O)c1ccccc1NC(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12
Show InChI InChI=1S/C26H23N3O4/c1-32-19-7-5-6-17(14-19)20-11-10-18(23-16-27-13-12-21(20)23)15-28-26(31)29-24-9-4-3-8-22(24)25(30)33-2/h3-14,16H,15H2,1-2H3,(H2,28,29,31)
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n/an/a 1.11E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360555
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)(C)Oc2ccc(cn2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C27H24F3N3O3/c1-26(2,36-24-10-8-19(15-32-24)27(28,29)30)25(34)33-14-18-7-9-21(22-11-12-31-16-23(18)22)17-5-4-6-20(13-17)35-3/h4-13,15-16H,14H2,1-3H3,(H,33,34)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360546
PNG
(1-((4-chlorophenyl)sulfonyl)-N-((5-(3- methoxyphen...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2(CC2)S(=O)(=O)c2ccc(Cl)cc2)c2cnccc12
Show InChI InChI=1S/C27H23ClN2O4S/c1-34-21-4-2-3-18(15-21)23-10-5-19(25-17-29-14-11-24(23)25)16-30-26(31)27(12-13-27)35(32,33)22-8-6-20(28)7-9-22/h2-11,14-15,17H,12-13,16H2,1H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360550
PNG
(2-(3-methoxyphenyl)-N-((5-(3- methoxyphenyl)isoqui...)
Show SMILES COc1cccc(c1)C1CC1C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12
Show InChI InChI=1S/C28H26N2O3/c1-32-21-7-3-5-18(13-21)23-10-9-20(27-17-29-12-11-24(23)27)16-30-28(31)26-15-25(26)19-6-4-8-22(14-19)33-2/h3-14,17,25-26H,15-16H2,1-2H3,(H,30,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360564
PNG
(5-bromo-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(Br)cnc2C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C24H17BrF3N3O2/c1-33-17-4-2-3-14(9-17)18-6-5-15(21-13-29-8-7-19(18)21)11-31-23(32)20-10-16(25)12-30-22(20)24(26,27)28/h2-10,12-13H,11H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360590
PNG
(2-(3,5-bis(trifluoromethyl)phenyl)-N- ((5-(3-metho...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C28H22F6N2O2/c1-16(19-10-20(27(29,30)31)13-21(11-19)28(32,33)34)26(37)36-14-18-6-7-23(24-8-9-35-15-25(18)24)17-4-3-5-22(12-17)38-2/h3-13,15-16H,14H2,1-2H3,(H,36,37)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360530
PNG
(3'-fluoro-N-((5-(3- methoxyphenyl)isoquinolin-8- y...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cccc(c2)-c2cccc(F)c2)c2cnccc12
Show InChI InChI=1S/C30H23FN2O2/c1-35-26-10-4-7-22(17-26)27-12-11-24(29-19-32-14-13-28(27)29)18-33-30(34)23-8-2-5-20(15-23)21-6-3-9-25(31)16-21/h2-17,19H,18H2,1H3,(H,33,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360603
PNG
(3-(8-((3-(2,3- dichlorophenyl)ureido)methyl)isoqui...)
Show SMILES CNC(=O)c1cccc(c1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C25H20Cl2N4O2/c1-28-24(32)16-5-2-4-15(12-16)18-9-8-17(20-14-29-11-10-19(18)20)13-30-25(33)31-22-7-3-6-21(26)23(22)27/h2-12,14H,13H2,1H3,(H,28,32)(H2,30,31,33)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360520
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccncc2-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C29H23N3O2/c1-34-23-9-5-8-21(16-23)24-11-10-22(28-19-30-14-12-25(24)28)17-32-29(33)26-13-15-31-18-27(26)20-6-3-2-4-7-20/h2-16,18-19H,17H2,1H3,(H,32,33)
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n/an/a 1.22E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360441
PNG
(US9828369, Example 13 | methyl 3-(8-((1-methyl-1H-...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2ccnn2C)c2cnccc12
Show InChI InChI=1S/C23H20N4O3/c1-27-21(9-11-26-27)22(28)25-13-17-6-7-18(19-8-10-24-14-20(17)19)15-4-3-5-16(12-15)23(29)30-2/h3-12,14H,13H2,1-2H3,(H,25,28)
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n/an/a 1.23E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360554
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)(C)Oc2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C28H25F3N2O3/c1-27(2,36-21-10-8-20(9-11-21)28(29,30)31)26(34)33-16-19-7-12-23(24-13-14-32-17-25(19)24)18-5-4-6-22(15-18)35-3/h4-15,17H,16H2,1-3H3,(H,33,34)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360521
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2csc(n2)-c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C28H20F3N3O2S/c1-36-21-4-2-3-18(13-21)22-10-7-19(24-15-32-12-11-23(22)24)14-33-26(35)25-16-37-27(34-25)17-5-8-20(9-6-17)28(29,30)31/h2-13,15-16H,14H2,1H3,(H,33,35)
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n/an/a 1.25E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360517
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccn(n2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H22N4O2/c1-33-22-9-5-6-19(16-22)23-11-10-20(25-18-28-14-12-24(23)25)17-29-27(32)26-13-15-31(30-26)21-7-3-2-4-8-21/h2-16,18H,17H2,1H3,(H,29,32)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360464
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)ox...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cnco2)c2cnccc12
Show InChI InChI=1S/C21H17N3O3/c1-26-16-4-2-3-14(9-16)17-6-5-15(19-11-22-8-7-18(17)19)10-24-21(25)20-12-23-13-27-20/h2-9,11-13H,10H2,1H3,(H,24,25)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360538
PNG
(US9828369, Example 95 | tert-butyl 3-(2-(((5-(3- m...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)CC2(CCN(C2)C(=O)OC(C)(C)C)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C34H37N3O4/c1-33(2,3)41-32(39)37-18-16-34(23-37,26-10-6-5-7-11-26)20-31(38)36-21-25-13-14-28(29-15-17-35-22-30(25)29)24-9-8-12-27(19-24)40-4/h5-15,17,19,22H,16,18,20-21,23H2,1-4H3,(H,36,38)
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n/an/a 1.31E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360485
PNG
(2-(4-chlorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(Cl)cc2)c2cnccc12
Show InChI InChI=1S/C25H21ClN2O2/c1-30-21-4-2-3-18(14-21)22-10-7-19(24-16-27-12-11-23(22)24)15-28-25(29)13-17-5-8-20(26)9-6-17/h2-12,14,16H,13,15H2,1H3,(H,28,29)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360529
PNG
(4'-fluoro-N-((5-(3- methoxyphenyl)isoquinolin-8- y...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc(cc2)-c2ccc(F)cc2)c2cnccc12
Show InChI InChI=1S/C30H23FN2O2/c1-35-26-4-2-3-23(17-26)27-14-11-24(29-19-32-16-15-28(27)29)18-33-30(34)22-7-5-20(6-8-22)21-9-12-25(31)13-10-21/h2-17,19H,18H2,1H3,(H,33,34)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360570
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-4...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cnccc2C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C24H18F3N3O2/c1-32-17-4-2-3-15(11-17)18-6-5-16(20-13-28-9-7-19(18)20)12-30-23(31)21-14-29-10-8-22(21)24(25,26)27/h2-11,13-14H,12H2,1H3,(H,30,31)
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n/an/a 1.42E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360471
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES CCCc1cc(C(=O)NCc2ccc(-c3cccc(OC)c3)c3ccncc23)n(C)n1
Show InChI InChI=1S/C25H26N4O2/c1-4-6-19-14-24(29(2)28-19)25(30)27-15-18-9-10-21(22-11-12-26-16-23(18)22)17-7-5-8-20(13-17)31-3/h5,7-14,16H,4,6,15H2,1-3H3,(H,27,30)
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n/an/a 1.43E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360526
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc(o2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H22N2O3/c1-32-22-9-5-8-20(16-22)23-11-10-21(25-18-29-15-14-24(23)25)17-30-28(31)27-13-12-26(33-27)19-6-3-2-4-7-19/h2-16,18H,17H2,1H3,(H,30,31)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360531
PNG
(3'-fluoro-N-((5-(3- methoxyphenyl)isoquinolin-8- y...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc(cc2)-c2cccc(F)c2)c2cnccc12
Show InChI InChI=1S/C30H23FN2O2/c1-35-26-7-3-5-23(17-26)27-13-12-24(29-19-32-15-14-28(27)29)18-33-30(34)21-10-8-20(9-11-21)22-4-2-6-25(31)16-22/h2-17,19H,18H2,1H3,(H,33,34)
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n/an/a 1.56E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360470
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2nn(C)c(=O)c3ccccc23)c2cnccc12
Show InChI InChI=1S/C27H22N4O3/c1-31-27(33)23-9-4-3-8-22(23)25(30-31)26(32)29-15-18-10-11-20(21-12-13-28-16-24(18)21)17-6-5-7-19(14-17)34-2/h3-14,16H,15H2,1-2H3,(H,29,32)
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n/an/a 1.57E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360499
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(c2)S(C)(=O)=O)c2cnccc12
Show InChI InChI=1S/C26H24N2O4S/c1-32-21-7-4-6-19(15-21)23-10-9-20(25-17-27-12-11-24(23)25)16-28-26(29)14-18-5-3-8-22(13-18)33(2,30)31/h3-13,15,17H,14,16H2,1-2H3,(H,28,29)
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n/an/a 1.64E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360511
PNG
(3-(3,5-dimethyl-1H-pyrazol-1-yl)-N- ((5-(3-methoxy...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cccc(c2)-n2nc(C)cc2C)c2cnccc12
Show InChI InChI=1S/C29H26N4O2/c1-19-14-20(2)33(32-19)24-8-4-7-22(15-24)29(34)31-17-23-10-11-26(27-12-13-30-18-28(23)27)21-6-5-9-25(16-21)35-3/h4-16,18H,17H2,1-3H3,(H,31,34)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360494
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccccc2C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C26H21F3N2O2/c1-33-20-7-4-6-17(13-20)21-10-9-19(23-16-30-12-11-22(21)23)15-31-25(32)14-18-5-2-3-8-24(18)26(27,28)29/h2-13,16H,14-15H2,1H3,(H,31,32)
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n/an/a 1.75E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360535
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)is...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cccc3cnccc23)c2cnccc12
Show InChI InChI=1S/C27H21N3O2/c1-32-21-6-2-4-18(14-21)22-9-8-20(26-17-29-13-11-24(22)26)16-30-27(31)25-7-3-5-19-15-28-12-10-23(19)25/h2-15,17H,16H2,1H3,(H,30,31)
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n/an/a 1.76E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360456
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(n[nH]2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C22H17F3N4O2/c1-31-15-4-2-3-13(9-15)16-6-5-14(18-12-26-8-7-17(16)18)11-27-21(30)19-10-20(29-28-19)22(23,24)25/h2-10,12H,11H2,1H3,(H,27,30)(H,28,29)
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n/an/a 1.77E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360449
PNG
(US9828369, Example 20 | isopropyl 3-(8-((2- phenyl...)
Show SMILES CC(C)OC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C30H28N2O3/c1-19(2)35-30(34)22-10-6-9-21(15-22)24-12-11-23(28-18-31-14-13-25(24)28)17-32-29(33)27-16-26(27)20-7-4-3-5-8-20/h3-15,18-19,26-27H,16-17H2,1-2H3,(H,32,33)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360510
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-4...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc(cc2)N2CCCC2=O)c2cnccc12
Show InChI InChI=1S/C28H25N3O3/c1-34-23-5-2-4-20(16-23)24-12-9-21(26-18-29-14-13-25(24)26)17-30-28(33)19-7-10-22(11-8-19)31-15-3-6-27(31)32/h2,4-5,7-14,16,18H,3,6,15,17H2,1H3,(H,30,33)
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n/an/a 1.95E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360604
PNG
(US9828369, Example 162 | tert-butyl 4-(8-((3-(2,3-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C27H28Cl2N4O3/c1-27(2,3)36-26(35)33-13-10-17(11-14-33)19-8-7-18(21-16-30-12-9-20(19)21)15-31-25(34)32-23-6-4-5-22(28)24(23)29/h4-10,12,16H,11,13-15H2,1-3H3,(H2,31,32,34)
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n/an/a 1.95E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360598
PNG
(US9828369, Example 155 | methyl 3-(8-((3-(2,3- dic...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C25H19Cl2N3O3/c1-33-24(31)16-5-2-4-15(12-16)18-9-8-17(20-14-28-11-10-19(18)20)13-29-25(32)30-22-7-3-6-21(26)23(22)27/h2-12,14H,13H2,1H3,(H2,29,30,32)
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n/an/a 1.96E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360491
PNG
(2-(2-chlorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccccc2Cl)c2cnccc12
Show InChI InChI=1S/C25H21ClN2O2/c1-30-20-7-4-6-17(13-20)21-10-9-19(23-16-27-12-11-22(21)23)15-28-25(29)14-18-5-2-3-8-24(18)26/h2-13,16H,14-15H2,1H3,(H,28,29)
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n/an/a 1.99E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360508
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-4...)
Show SMILES COc1cccc(c1)-c1ccc(CNCc2ccc(cc2)-n2cccn2)c2cnccc12
Show InChI InChI=1S/C27H24N4O/c1-32-24-5-2-4-21(16-24)25-11-8-22(27-19-28-14-12-26(25)27)18-29-17-20-6-9-23(10-7-20)31-15-3-13-30-31/h2-16,19,29H,17-18H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360578
PNG
(2-(3-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2cccc(F)c2)c2cnccc12
Show InChI InChI=1S/C26H23FN2O2/c1-17(18-5-3-7-21(27)13-18)26(30)29-15-20-9-10-23(24-11-12-28-16-25(20)24)19-6-4-8-22(14-19)31-2/h3-14,16-17H,15H2,1-2H3,(H,29,30)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360459
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)q...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cccc3cccnc23)c2cnccc12
Show InChI InChI=1S/C27H21N3O2/c1-32-21-8-2-6-19(15-21)22-11-10-20(25-17-28-14-12-23(22)25)16-30-27(31)24-9-3-5-18-7-4-13-29-26(18)24/h2-15,17H,16H2,1H3,(H,30,31)
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n/an/a 2.01E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360453
PNG
(5-cyclopropyl-N-((5-(3- methoxyphenyl)isoquinolin-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(on2)C2CC2)c2cnccc12
Show InChI InChI=1S/C24H21N3O3/c1-29-18-4-2-3-16(11-18)19-8-7-17(21-14-25-10-9-20(19)21)13-26-24(28)22-12-23(30-27-22)15-5-6-15/h2-4,7-12,14-15H,5-6,13H2,1H3,(H,26,28)
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n/an/a 2.05E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360503
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cc(F)c(F)c(F)c2)c2cnccc12
Show InChI InChI=1S/C25H19F3N2O2/c1-32-18-4-2-3-16(12-18)19-6-5-17(21-14-29-8-7-20(19)21)13-30-24(31)11-15-9-22(26)25(28)23(27)10-15/h2-10,12,14H,11,13H2,1H3,(H,30,31)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360496
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(Oc3ccccc3)cc2)c2cnccc12
Show InChI InChI=1S/C31H26N2O3/c1-35-27-9-5-6-23(19-27)28-15-12-24(30-21-32-17-16-29(28)30)20-33-31(34)18-22-10-13-26(14-11-22)36-25-7-3-2-4-8-25/h2-17,19,21H,18,20H2,1H3,(H,33,34)
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n/an/a 2.16E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360532
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2nc(cs2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H23N3O2S/c1-33-22-9-5-8-20(14-22)23-11-10-21(25-17-29-13-12-24(23)25)16-30-27(32)15-28-31-26(18-34-28)19-6-3-2-4-7-19/h2-14,17-18H,15-16H2,1H3,(H,30,32)
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n/an/a 2.23E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360513
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2coc(n2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H21N3O3/c1-32-21-9-5-8-19(14-21)22-11-10-20(24-16-28-13-12-23(22)24)15-29-26(31)25-17-33-27(30-25)18-6-3-2-4-7-18/h2-14,16-17H,15H2,1H3,(H,29,31)
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n/an/a 2.33E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360567
PNG
(2-fluoro-N-((5-(3- methoxyphenyl)isoquinolin-8- yl...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(F)c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C26H20F4N2O2/c1-34-20-4-2-3-17(13-20)21-10-7-18(23-15-31-12-11-22(21)23)14-32-25(33)24(27)16-5-8-19(9-6-16)26(28,29)30/h2-13,15,24H,14H2,1H3,(H,32,33)
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n/an/a 2.33E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360605
PNG
(3-(4-(8-((3-(2,3- dichlorophenyl)ureido)methyl)iso...)
Show SMILES OC(=O)CCc1ccc(cc1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C26H21Cl2N3O3/c27-22-2-1-3-23(25(22)28)31-26(34)30-14-18-9-10-19(20-12-13-29-15-21(18)20)17-7-4-16(5-8-17)6-11-24(32)33/h1-5,7-10,12-13,15H,6,11,14H2,(H,32,33)(H2,30,31,34)
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n/an/a 2.36E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360523
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(no2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H21N3O3/c1-32-21-9-5-8-19(14-21)22-11-10-20(24-17-28-13-12-23(22)24)16-29-27(31)26-15-25(30-33-26)18-6-3-2-4-7-18/h2-15,17H,16H2,1H3,(H,29,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360568
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C(C)C)c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C29H27F3N2O2/c1-18(2)27(19-7-10-22(11-8-19)29(30,31)32)28(35)34-16-21-9-12-24(25-13-14-33-17-26(21)25)20-5-4-6-23(15-20)36-3/h4-15,17-18,27H,16H2,1-3H3,(H,34,35)
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n/an/a 2.46E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360587
PNG
((cis)-N-((5-(3-methoxyphenyl) isoquinolin-8-yl)met...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@@H]2c2ccc(cc2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C28H23F3N2O2/c1-35-21-4-2-3-18(13-21)22-10-7-19(26-16-32-12-11-23(22)26)15-33-27(34)25-14-24(25)17-5-8-20(9-6-17)28(29,30)31/h2-13,16,24-25H,14-15H2,1H3,(H,33,34)/t24-,25-/m1/s1
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n/an/a 2.56E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360497
PNG
(2-(3-chlorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(Cl)c2)c2cnccc12
Show InChI InChI=1S/C25H21ClN2O2/c1-30-21-7-3-5-18(14-21)22-9-8-19(24-16-27-11-10-23(22)24)15-28-25(29)13-17-4-2-6-20(26)12-17/h2-12,14,16H,13,15H2,1H3,(H,28,29)
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n/an/a 2.76E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360572
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cncc(c2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C29H23N3O2/c1-34-25-9-5-8-21(15-25)26-11-10-22(28-19-30-13-12-27(26)28)18-32-29(33)24-14-23(16-31-17-24)20-6-3-2-4-7-20/h2-17,19H,18H2,1H3,(H,32,33)
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n/an/a 2.99E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360463
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc3OCCOc3c2)c2cnccc12
Show InChI InChI=1S/C26H22N2O4/c1-30-20-4-2-3-17(13-20)21-7-5-19(23-16-27-10-9-22(21)23)15-28-26(29)18-6-8-24-25(14-18)32-12-11-31-24/h2-10,13-14,16H,11-12,15H2,1H3,(H,28,29)
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n/an/a 3.01E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360506
PNG
(2-(2,3-dihydrobenzo[b][1,4]dioxin-6- yl)-N-((5-(3-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccc3OCCOc3c2)c2cnccc12
Show InChI InChI=1S/C27H24N2O4/c1-31-21-4-2-3-19(15-21)22-7-6-20(24-17-28-10-9-23(22)24)16-29-27(30)14-18-5-8-25-26(13-18)33-12-11-32-25/h2-10,13,15,17H,11-12,14,16H2,1H3,(H,29,30)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360465
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)ox...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ncco2)c2cnccc12
Show InChI InChI=1S/C21H17N3O3/c1-26-16-4-2-3-14(11-16)17-6-5-15(19-13-22-8-7-18(17)19)12-24-20(25)21-23-9-10-27-21/h2-11,13H,12H2,1H3,(H,24,25)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360597
PNG
(N-((5-(3-methoxyphenyl)isoquinolin-8- yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccn(C)n2)c2cnccc12
Show InChI InChI=1S/C22H20N4O2/c1-26-11-9-21(25-26)22(27)24-13-16-6-7-18(19-8-10-23-14-20(16)19)15-4-3-5-17(12-15)28-2/h3-12,14H,13H2,1-2H3,(H,24,27)
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n/an/a 3.27E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360558
PNG
(1-benzyl-N-((5-(3- methoxyphenyl)isoquinolin-8- yl...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cnn(Cc3ccccc3)c2)c2cnccc12
Show InChI InChI=1S/C28H24N4O2/c1-34-24-9-5-8-21(14-24)25-11-10-22(27-17-29-13-12-26(25)27)15-30-28(33)23-16-31-32(19-23)18-20-6-3-2-4-7-20/h2-14,16-17,19H,15,18H2,1H3,(H,30,33)
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n/an/a 3.39E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360561
PNG
(5-bromo-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ncc(Br)cn2)c2cnccc12
Show InChI InChI=1S/C22H17BrN4O2/c1-29-17-4-2-3-14(9-17)18-6-5-15(20-13-24-8-7-19(18)20)10-27-22(28)21-25-11-16(23)12-26-21/h2-9,11-13H,10H2,1H3,(H,27,28)
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n/an/a 3.39E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360460
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)is...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cncc3ccccc23)c2cnccc12
Show InChI InChI=1S/C27H21N3O2/c1-32-21-7-4-6-18(13-21)23-10-9-20(25-16-28-12-11-24(23)25)15-30-27(31)26-17-29-14-19-5-2-3-8-22(19)26/h2-14,16-17H,15H2,1H3,(H,30,31)
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n/an/a 3.41E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360512
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccnc(c2)-n2cnnn2)c2cnccc12
Show InChI InChI=1S/C24H19N7O2/c1-33-19-4-2-3-16(11-19)20-6-5-18(22-14-25-9-8-21(20)22)13-27-24(32)17-7-10-26-23(12-17)31-15-28-29-30-31/h2-12,14-15H,13H2,1H3,(H,27,32)
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n/an/a 3.41E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360462
PNG
(3-ethyl-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)...)
Show SMILES CCc1cc(C(=O)NCc2ccc(-c3cccc(OC)c3)c3ccncc23)n(C)n1
Show InChI InChI=1S/C24H24N4O2/c1-4-18-13-23(28(2)27-18)24(29)26-14-17-8-9-20(21-10-11-25-15-22(17)21)16-6-5-7-19(12-16)30-3/h5-13,15H,4,14H2,1-3H3,(H,26,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360445
PNG
((trans)-N-((5-(3- cyanophenyl)isoquinolin-8-yl)met...)
Show SMILES O=C(NCc1ccc(-c2cccc(c2)C#N)c2ccncc12)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C27H21N3O/c28-15-18-5-4-8-20(13-18)22-10-9-21(26-17-29-12-11-23(22)26)16-30-27(31)25-14-24(25)19-6-2-1-3-7-19/h1-13,17,24-25H,14,16H2,(H,30,31)/t24-,25+/m0/s1
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n/an/a 3.47E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360469
PNG
((R/S)-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)me...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2COC(=N2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H23N3O3/c1-32-21-9-5-8-19(14-21)22-11-10-20(24-16-28-13-12-23(22)24)15-29-26(31)25-17-33-27(30-25)18-6-3-2-4-7-18/h2-14,16,25H,15,17H2,1H3,(H,29,31)/t25-/m0/s1
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n/an/a 3.55E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360528
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(nn2-c2ccccc2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C33H26N4O2/c1-39-27-14-8-11-24(19-27)28-16-15-25(30-22-34-18-17-29(28)30)21-35-33(38)32-20-31(23-9-4-2-5-10-23)36-37(32)26-12-6-3-7-13-26/h2-20,22H,21H2,1H3,(H,35,38)
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n/an/a 3.58E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360495
PNG
(2-(3-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(F)c2)c2cnccc12
Show InChI InChI=1S/C25H21FN2O2/c1-30-21-7-3-5-18(14-21)22-9-8-19(24-16-27-11-10-23(22)24)15-28-25(29)13-17-4-2-6-20(26)12-17/h2-12,14,16H,13,15H2,1H3,(H,28,29)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360446
PNG
(2-phenyl-N-((5-(3- (trifluoromethoxy)phenyl)isoqui...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H21F3N2O2/c28-27(29,30)34-20-8-4-7-18(13-20)21-10-9-19(25-16-31-12-11-22(21)25)15-32-26(33)24-14-23(24)17-5-2-1-3-6-17/h1-13,16,23-24H,14-15H2,(H,32,33)
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n/an/a 3.76E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360515
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2noc(n2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C26H20N4O3/c1-32-20-9-5-8-18(14-20)21-11-10-19(23-16-27-13-12-22(21)23)15-28-25(31)24-29-26(33-30-24)17-6-3-2-4-7-17/h2-14,16H,15H2,1H3,(H,28,31)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360455
PNG
(5-bromo-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cncc(Br)c2)c2cnccc12
Show InChI InChI=1S/C23H18BrN3O2/c1-29-19-4-2-3-15(10-19)20-6-5-16(22-14-25-8-7-21(20)22)12-27-23(28)17-9-18(24)13-26-11-17/h2-11,13-14H,12H2,1H3,(H,27,28)
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n/an/a 3.93E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360575
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cnn(c2C(F)(F)F)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H21F3N4O2/c1-37-21-9-5-6-18(14-21)22-11-10-19(24-16-32-13-12-23(22)24)15-33-27(36)25-17-34-35(26(25)28(29,30)31)20-7-3-2-4-8-20/h2-14,16-17H,15H2,1H3,(H,33,36)
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n/an/a 3.94E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360514
PNG
(2-((5-hydroxy-1,2,3-oxadiazol-3(2H)- yl)methyl)-N-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccccc2CN2NOC(O)=C2)c2cnccc12
Show InChI InChI=1S/C27H24N4O4/c1-34-21-7-4-6-18(13-21)22-10-9-19(25-15-28-12-11-24(22)25)14-29-27(33)23-8-3-2-5-20(23)16-31-17-26(32)35-30-31/h2-13,15,17,30,32H,14,16H2,1H3,(H,29,33)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360606
PNG
(1-(2,3-dichlorophenyl)-3-((5-(1- phenylethyl)isoqu...)
Show SMILES CC(c1ccccc1)c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C25H21Cl2N3O/c1-16(17-6-3-2-4-7-17)19-11-10-18(21-15-28-13-12-20(19)21)14-29-25(31)30-23-9-5-8-22(26)24(23)27/h2-13,15-16H,14H2,1H3,(H2,29,30,31)
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n/an/a 4.22E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360563
PNG
(5-bromo-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(Br)cnc2-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C29H22BrN3O2/c1-35-23-9-5-8-20(14-23)24-11-10-21(27-18-31-13-12-25(24)27)16-33-29(34)26-15-22(30)17-32-28(26)19-6-3-2-4-7-19/h2-15,17-18H,16H2,1H3,(H,33,34)
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n/an/a 4.24E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360607
PNG
(US9828369, Example 165 | tert-butyl 3-(8-((3-(2,3-...)
Show SMILES CC(C)(C)OC(=O)N1CCC=C(C1)c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C27H28Cl2N4O3/c1-27(2,3)36-26(35)33-13-5-6-18(16-33)19-10-9-17(21-15-30-12-11-20(19)21)14-31-25(34)32-23-8-4-7-22(28)24(23)29/h4,6-12,15H,5,13-14,16H2,1-3H3,(H2,31,32,34)
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n/an/a 4.31E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360608
PNG
(1-(2,3-dichlorophenyl)-3-((5-(3- (morpholine-4- ca...)
Show SMILES Clc1cccc(NC(=O)NCc2ccc(-c3cccc(c3)C(=O)N3CCOCC3)c3ccncc23)c1Cl
Show InChI InChI=1S/C28H24Cl2N4O3/c29-24-5-2-6-25(26(24)30)33-28(36)32-16-20-7-8-21(22-9-10-31-17-23(20)22)18-3-1-4-19(15-18)27(35)34-11-13-37-14-12-34/h1-10,15,17H,11-14,16H2,(H2,32,33,36)
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n/an/a 4.41E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360609
PNG
(1-(2,3-dichlorophenyl)-3-((5-(2,5- dihydro-1H-pyrr...)
Show SMILES Clc1cccc(NC(=O)NCc2ccc(C3=CCNC3)c3ccncc23)c1Cl
Show InChI InChI=1S/C21H18Cl2N4O/c22-18-2-1-3-19(20(18)23)27-21(28)26-11-13-4-5-15(14-6-8-24-10-14)16-7-9-25-12-17(13)16/h1-7,9,12,24H,8,10-11H2,(H2,26,27,28)
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n/an/a 4.42E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360500
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(OC(F)(F)F)cc2)c2cnccc12
Show InChI InChI=1S/C26H21F3N2O3/c1-33-21-4-2-3-18(14-21)22-10-7-19(24-16-30-12-11-23(22)24)15-31-25(32)13-17-5-8-20(9-6-17)34-26(27,28)29/h2-12,14,16H,13,15H2,1H3,(H,31,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360519
PNG
(4-(isoxazol-3-yl)-N-((5-(3- methoxyphenyl)isoquino...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc(cc2)-c2ccon2)c2cnccc12
Show InChI InChI=1S/C27H21N3O3/c1-32-22-4-2-3-20(15-22)23-10-9-21(25-17-28-13-11-24(23)25)16-29-27(31)19-7-5-18(6-8-19)26-12-14-33-30-26/h2-15,17H,16H2,1H3,(H,29,31)
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n/an/a 4.46E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360516
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2c[nH]c(n2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H22N4O2/c1-33-21-9-5-8-19(14-21)22-11-10-20(24-16-28-13-12-23(22)24)15-30-27(32)25-17-29-26(31-25)18-6-3-2-4-7-18/h2-14,16-17H,15H2,1H3,(H,29,31)(H,30,32)
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n/an/a 5.84E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360556
PNG
(1-benzyl-N-((5-(3- methoxyphenyl)isoquinolin-8- yl...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cn(Cc3ccccc3)nn2)c2cnccc12
Show InChI InChI=1S/C27H23N5O2/c1-34-22-9-5-8-20(14-22)23-11-10-21(25-16-28-13-12-24(23)25)15-29-27(33)26-18-32(31-30-26)17-19-6-3-2-4-7-19/h2-14,16,18H,15,17H2,1H3,(H,29,33)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360562
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cncc(c2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C24H18F3N3O2/c1-32-19-4-2-3-15(10-19)20-6-5-16(22-14-28-8-7-21(20)22)12-30-23(31)17-9-18(13-29-11-17)24(25,26)27/h2-11,13-14H,12H2,1H3,(H,30,31)
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n/an/a 5.89E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360467
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)qu...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2ccc3nccnc3c2)c2cnccc12
Show InChI InChI=1S/C26H20N4O2/c1-32-20-4-2-3-17(13-20)21-7-5-19(23-16-27-10-9-22(21)23)15-30-26(31)18-6-8-24-25(14-18)29-12-11-28-24/h2-14,16H,15H2,1H3,(H,30,31)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360557
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)(C)Oc2cc(ccn2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C27H24F3N3O3/c1-26(2,36-24-14-19(9-12-32-24)27(28,29)30)25(34)33-15-18-7-8-21(22-10-11-31-16-23(18)22)17-5-4-6-20(13-17)35-3/h4-14,16H,15H2,1-3H3,(H,33,34)
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n/an/a 6.11E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360450
PNG
(3-(8-((2- phenylcyclopropanecarboxamido) methyl)is...)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H23N3O2/c28-26(31)19-8-4-7-18(13-19)21-10-9-20(25-16-29-12-11-22(21)25)15-30-27(32)24-14-23(24)17-5-2-1-3-6-17/h1-13,16,23-24H,14-15H2,(H2,28,31)(H,30,32)
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n/an/a 6.27E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360536
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)CN2CCN(CC2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C29H30N4O2/c1-35-25-9-5-6-22(18-25)26-11-10-23(28-20-30-13-12-27(26)28)19-31-29(34)21-32-14-16-33(17-15-32)24-7-3-2-4-8-24/h2-13,18,20H,14-17,19,21H2,1H3,(H,31,34)
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n/an/a 6.67E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360454
PNG
(3-(furan-2-yl)-N-((5-(3- methoxyphenyl)isoquinolin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)CC(c2ccco2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C30H26N2O3/c1-34-24-10-5-9-22(17-24)25-13-12-23(28-20-31-15-14-26(25)28)19-32-30(33)18-27(29-11-6-16-35-29)21-7-3-2-4-8-21/h2-17,20,27H,18-19H2,1H3,(H,32,33)
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n/an/a 6.83E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360591
PNG
(2-(3-chloro-4-cyclohexylphenyl)-N- ((5-(3-methoxyp...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccc(C3CCCCC3)c(Cl)c2)c2cnccc12
Show InChI InChI=1S/C32H33ClN2O2/c1-21(23-11-14-28(31(33)18-23)22-7-4-3-5-8-22)32(36)35-19-25-12-13-27(29-15-16-34-20-30(25)29)24-9-6-10-26(17-24)37-2/h6,9-18,20-22H,3-5,7-8,19H2,1-2H3,(H,35,36)
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n/an/a 6.89E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360610
PNG
(1-([1,1'-biphenyl]-2-yl)-3-((5-(3- methoxyphenyl)i...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Nc2ccccc2-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C30H25N3O2/c1-35-24-11-7-10-22(18-24)25-15-14-23(28-20-31-17-16-27(25)28)19-32-30(34)33-29-13-6-5-12-26(29)21-8-3-2-4-9-21/h2-18,20H,19H2,1H3,(H2,32,33,34)
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n/an/a 7.07E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360565
PNG
(2-(5-bromopyridin-3-yl)-N-((5-(3- methoxyphenyl)is...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cncc(Br)c2)c2cnccc12
Show InChI InChI=1S/C24H20BrN3O2/c1-30-20-4-2-3-17(11-20)21-6-5-18(23-15-26-8-7-22(21)23)13-28-24(29)10-16-9-19(25)14-27-12-16/h2-9,11-12,14-15H,10,13H2,1H3,(H,28,29)
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n/an/a 7.13E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360501
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2ccc(F)c(F)c2F)c2cnccc12
Show InChI InChI=1S/C25H19F3N2O2/c1-32-18-4-2-3-15(11-18)19-7-5-17(21-14-29-10-9-20(19)21)13-30-23(31)12-16-6-8-22(26)25(28)24(16)27/h2-11,14H,12-13H2,1H3,(H,30,31)
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n/an/a 7.29E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360461
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-3...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cccc(c2)-n2cccn2)c2cnccc12
Show InChI InChI=1S/C27H22N4O2/c1-33-23-8-3-5-19(16-23)24-10-9-21(26-18-28-13-11-25(24)26)17-29-27(32)20-6-2-7-22(15-20)31-14-4-12-30-31/h2-16,18H,17H2,1H3,(H,29,32)
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n/an/a 7.36E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360541
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC22CCCC2)c2cnccc12
Show InChI InChI=1S/C25H26N2O2/c1-29-19-6-4-5-17(13-19)20-8-7-18(22-16-26-12-9-21(20)22)15-27-24(28)23-14-25(23)10-2-3-11-25/h4-9,12-13,16,23H,2-3,10-11,14-15H2,1H3,(H,27,28)
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n/an/a 7.40E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360548
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccn2)c2cnccc12
Show InChI InChI=1S/C26H23N3O2/c1-31-19-6-4-5-17(13-19)20-9-8-18(24-16-27-12-10-21(20)24)15-29-26(30)23-14-22(23)25-7-2-3-11-28-25/h2-13,16,22-23H,14-15H2,1H3,(H,29,30)
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n/an/a 7.45E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360599
PNG
(US9828369, Example 156 | ethyl 3-(8-((3-(2,3-dichl...)
Show SMILES CCOC(=O)CCc1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C22H21Cl2N3O3/c1-2-30-20(28)9-8-14-6-7-15(17-13-25-11-10-16(14)17)12-26-22(29)27-19-5-3-4-18(23)21(19)24/h3-7,10-11,13H,2,8-9,12H2,1H3,(H2,26,27,29)
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n/an/a 7.61E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360468
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CCCN(C2)c2ccccn2)c2cnccc12
Show InChI InChI=1S/C28H28N4O2/c1-34-23-8-4-6-20(16-23)24-11-10-21(26-18-29-14-12-25(24)26)17-31-28(33)22-7-5-15-32(19-22)27-9-2-3-13-30-27/h2-4,6,8-14,16,18,22H,5,7,15,17,19H2,1H3,(H,31,33)
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n/an/a 7.78E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360539
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CCC(=N2)c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H25N3O2/c1-33-22-9-5-8-20(16-22)23-11-10-21(25-18-29-15-14-24(23)25)17-30-28(32)27-13-12-26(31-27)19-6-3-2-4-7-19/h2-11,14-16,18,27H,12-13,17H2,1H3,(H,30,32)
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Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360559
PNG
(2-(5-bromopyridin-2-yl)-2,2-difluoro- N-((5-(3-met...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(F)(F)c2ccc(Br)cn2)c2cnccc12
Show InChI InChI=1S/C24H18BrF2N3O2/c1-32-18-4-2-3-15(11-18)19-7-5-16(21-14-28-10-9-20(19)21)12-30-23(31)24(26,27)22-8-6-17(25)13-29-22/h2-11,13-14H,12H2,1H3,(H,30,31)
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n/an/a 8.13E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360611
PNG
(1-(2,4-difluorophenyl)-3-((5-(3- methoxyphenyl)qui...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Nc2ccc(F)cc2F)c2ncccc12
Show InChI InChI=1S/C24H19F2N3O2/c1-31-18-5-2-4-15(12-18)19-9-7-16(23-20(19)6-3-11-27-23)14-28-24(30)29-22-10-8-17(25)13-21(22)26/h2-13H,14H2,1H3,(H2,28,29,30)
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n/an/a 8.19E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360522
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cnn(c2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C27H22N4O2/c1-33-23-9-5-6-19(14-23)24-11-10-20(26-17-28-13-12-25(24)26)15-29-27(32)21-16-30-31(18-21)22-7-3-2-4-8-22/h2-14,16-18H,15H2,1H3,(H,29,32)
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n/an/a 8.49E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360612
PNG
(1-(2,3-dichlorophenyl)-3-((5-(3- methoxyphenyl)qui...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2ncccc12
Show InChI InChI=1S/C24H19Cl2N3O2/c1-31-17-6-2-5-15(13-17)18-11-10-16(23-19(18)7-4-12-27-23)14-28-24(30)29-21-9-3-8-20(25)22(21)26/h2-13H,14H2,1H3,(H2,28,29,30)
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n/an/a 9.02E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360518
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cnc(cn2)-c2ccccc2)c2cnccc12
Show InChI InChI=1S/C28H22N4O2/c1-34-22-9-5-8-20(14-22)23-11-10-21(25-16-29-13-12-24(23)25)15-32-28(33)27-18-30-26(17-31-27)19-6-3-2-4-7-19/h2-14,16-18H,15H2,1H3,(H,32,33)
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n/an/a 9.05E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360466
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-4...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2noc3CCCCc23)c2cnccc12
Show InChI InChI=1S/C25H23N3O3/c1-30-18-6-4-5-16(13-18)19-10-9-17(22-15-26-12-11-20(19)22)14-27-25(29)24-21-7-2-3-8-23(21)31-28-24/h4-6,9-13,15H,2-3,7-8,14H2,1H3,(H,27,29)
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KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.39E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360451
PNG
((1S,2S)-2-(4-methoxyphenyl)-N-((5- (3-methoxypheny...)
Show SMILES COc1ccc(cc1)C1CC1C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12
Show InChI InChI=1S/C28H26N2O3/c1-32-21-9-6-18(7-10-21)25-15-26(25)28(31)30-16-20-8-11-23(24-12-13-29-17-27(20)24)19-4-3-5-22(14-19)33-2/h3-14,17,25-26H,15-16H2,1-2H3,(H,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.96E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%