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Patent code US9828378

Compile Data Set for Download or QSAR

Found 257 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315515
PNG
(US10172858, Table 2.11 | US9828378, # 11)
Show SMILES CC(C)n1nc(-c2cc3cccc(O)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6O/c1-8(2)22-16-12(15(17)18-7-19-16)14(21-22)10-6-9-4-3-5-11(23)13(9)20-10/h3-8,20,23H,1-2H3,(H2,17,18,19)
PDB

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US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315547
PNG
(US10172858, Table 2.42 | US9828378, # 42)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H18N6O2/c19-17-15-16(14-8-10-7-12(25)1-2-13(10)22-14)23-24(18(15)21-9-20-17)11-3-5-26-6-4-11/h1-2,7-9,11,22,25H,3-6H2,(H2,19,20,21)
PDB

GoogleScholar
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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315572
PNG
(US10172858, Table 2.68 | US9828378, # 68)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)cc(Cl)c4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H17ClN6O2/c19-12-7-11(26)5-9-6-13(23-15(9)12)16-14-17(20)21-8-22-18(14)25(24-16)10-1-3-27-4-2-10/h5-8,10,23,26H,1-4H2,(H2,20,21,22)
PDB

GoogleScholar
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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315574
PNG
(US10172858, Table 2.70 | US9828378, # 70)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3cc(O)cc(Cl)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O2/c1-10(29)27-4-2-12(3-5-27)28-20-16(19(22)23-9-24-20)18(26-28)15-7-11-6-13(30)8-14(21)17(11)25-15/h6-9,12,25,30H,2-5H2,1H3,(H2,22,23,24)
PDB

GoogleScholar
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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315566
PNG
(US10172858, Table 2.63 | US9828378, # 63)
Show SMILES COc1cccc2cc([nH]c12)-c1nn(C2CCOCC2)c2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O2/c1-26-14-4-2-3-11-9-13(23-16(11)14)17-15-18(20)21-10-22-19(15)25(24-17)12-5-7-27-8-6-12/h2-4,9-10,12,23H,5-8H2,1H3,(H2,20,21,22)
PDB

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US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315573
PNG
(US10172858, Table 2.69 | US9828378, # 69)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3c(Cl)ccc(O)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O2/c1-10(29)27-6-4-11(5-7-27)28-20-16(19(22)23-9-24-20)18(26-28)14-8-12-13(21)2-3-15(30)17(12)25-14/h2-3,8-9,11,25,30H,4-7H2,1H3,(H2,22,23,24)
PDB

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US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315519
PNG
(US10172858, Table 2.15 | US9828378, # 15)
Show SMILES CC(C)n1nc(-c2cc3cc(O)cc(Cl)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6O/c1-7(2)23-16-12(15(18)19-6-20-16)14(22-23)11-4-8-3-9(24)5-10(17)13(8)21-11/h3-7,21,24H,1-2H3,(H2,18,19,20)
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315520
PNG
(US10172858, Table 2.16 | US9828378, # 16)
Show SMILES CC(C)n1nc(-c2cc3cc(O)cc(F)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15FN6O/c1-7(2)23-16-12(15(18)19-6-20-16)14(22-23)11-4-8-3-9(24)5-10(17)13(8)21-11/h3-7,21,24H,1-2H3,(H2,18,19,20)
PDB

GoogleScholar
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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315526
PNG
(US10172858, Table 2.22 | US9828378, # 22)
Show SMILES CC(C)n1nc(-c2cc3c(Cl)c(O)ccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6O/c1-7(2)23-16-12(15(18)19-6-20-16)14(22-23)10-5-8-9(21-10)3-4-11(24)13(8)17/h3-7,21,24H,1-2H3,(H2,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315565
PNG
(US10172858, Table 2.62 | US9828378, # 62)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccc(O)c4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H18N6O2/c19-17-14-16(12-8-10-2-1-3-13(25)15(10)22-12)23-24(18(14)21-9-20-17)11-4-6-26-7-5-11/h1-3,8-9,11,22,25H,4-7H2,(H2,19,20,21)
PDB

GoogleScholar
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PC sid
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US Patent
n/an/a<5n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM315522
PNG
(US10172858, Table 2.18 | US9828378, # 18)
Show SMILES COc1ccc2[nH]c(cc2n1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C16H17N7O/c1-8(2)23-16-13(15(17)18-7-19-16)14(22-23)11-6-10-9(20-11)4-5-12(21-10)24-3/h4-8,20H,1-3H3,(H2,17,18,19)
PDB
MMDB

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n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315552
PNG
(US10172858, Table 2.49 | US9828378, # 49)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CC(C1)N1CCOCC1
Show InChI InChI=1S/C21H23N7O2/c22-20-18-19(17-8-12-7-15(29)1-2-16(12)25-17)26-28(21(18)24-11-23-20)14-9-13(10-14)27-3-5-30-6-4-27/h1-2,7-8,11,13-14,25,29H,3-6,9-10H2,(H2,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315544
PNG
(US10172858, Table 2.39 | US9828378, # 39)
Show SMILES CC(C)n1nc(-c2cc3c(Cl)ccc(O)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6O/c1-7(2)23-16-12(15(18)19-6-20-16)14(22-23)10-5-8-9(17)3-4-11(24)13(8)21-10/h3-7,21,24H,1-2H3,(H2,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315516
PNG
(US10172858, Table 2.12 | US9828378, # 12)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCCC1
Show InChI InChI=1S/C18H18N6O/c19-17-15-16(14-8-10-7-12(25)5-6-13(10)22-14)23-24(11-3-1-2-4-11)18(15)21-9-20-17/h5-9,11,22,25H,1-4H2,(H2,19,20,21)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315541
PNG
(US10172858, Table 2.36 | US9828378, # 36)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccc(O)c4[nH]3)c12)C1CCCC1
Show InChI InChI=1S/C18H18N6O/c19-17-14-16(12-8-10-4-3-7-13(25)15(10)22-12)23-24(11-5-1-2-6-11)18(14)21-9-20-17/h3-4,7-9,11,22,25H,1-2,5-6H2,(H2,19,20,21)
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315531
PNG
(US10172858, Table 2.26 | US9828378, # 26)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCCCC1
Show InChI InChI=1S/C19H20N6O/c20-18-16-17(15-9-11-8-13(26)6-7-14(11)23-15)24-25(19(16)22-10-21-18)12-4-2-1-3-5-12/h6-10,12,23,26H,1-5H2,(H2,20,21,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315568
PNG
(US10172858, Table 2.65 | US9828378, # 65)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3ccc(O)cc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H21N7O2/c1-11(28)26-6-4-13(5-7-26)27-20-17(19(21)22-10-23-20)18(25-27)16-8-12-2-3-14(29)9-15(12)24-16/h2-3,8-10,13,24,29H,4-7H2,1H3,(H2,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315546
PNG
(US10172858, Table 2.41 | US9828378, # 41)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccc(O)c4[nH]3)c12)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C22H23N7O2/c23-20-17-19(15-10-13-2-1-3-16(30)18(13)26-15)27-29(21(17)25-11-24-20)14-6-8-28(9-7-14)22(31)12-4-5-12/h1-3,10-12,14,26,30H,4-9H2,(H2,23,24,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315532
PNG
(US10172858, Table 2.27 | US9828378, # 27)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCC1
Show InChI InChI=1S/C17H16N6O/c18-16-14-15(13-7-9-6-11(24)4-5-12(9)21-13)22-23(10-2-1-3-10)17(14)20-8-19-16/h4-8,10,21,24H,1-3H2,(H2,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<25n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315568
PNG
(US10172858, Table 2.65 | US9828378, # 65)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3ccc(O)cc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H21N7O2/c1-11(28)26-6-4-13(5-7-26)27-20-17(19(21)22-10-23-20)18(25-27)16-8-12-2-3-14(29)9-15(12)24-16/h2-3,8-10,13,24,29H,4-7H2,1H3,(H2,21,22,23)
PDB
MMDB

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UniChem
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n/an/a<25n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315567
PNG
(US10172858, Table 2.64 | US9828378, # 64)
Show SMILES CC(C)N1CCC(CC1)n1nc(-c2cc3cccc(O)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C21H25N7O/c1-12(2)27-8-6-14(7-9-27)28-21-17(20(22)23-11-24-21)19(26-28)15-10-13-4-3-5-16(29)18(13)25-15/h3-5,10-12,14,25,29H,6-9H2,1-2H3,(H2,22,23,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<25n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315574
PNG
(US10172858, Table 2.70 | US9828378, # 70)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3cc(O)cc(Cl)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O2/c1-10(29)27-4-2-12(3-5-27)28-20-16(19(22)23-9-24-20)18(26-28)15-7-11-6-13(30)8-14(21)17(11)25-15/h6-9,12,25,30H,2-5H2,1H3,(H2,22,23,24)
PDB
MMDB

NCI pathway
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UniProtKB/SwissProt

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<25n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315572
PNG
(US10172858, Table 2.68 | US9828378, # 68)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)cc(Cl)c4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H17ClN6O2/c19-12-7-11(26)5-9-6-13(23-15(9)12)16-14-17(20)21-8-22-18(14)25(24-16)10-1-3-27-4-2-10/h5-8,10,23,26H,1-4H2,(H2,20,21,22)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315557
PNG
(US10172858, Table 2.54 | US9828378, # 54)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CC(O)C1
Show InChI InChI=1S/C17H16N6O2/c18-16-14-15(13-4-8-3-10(24)1-2-12(8)21-13)22-23(9-5-11(25)6-9)17(14)20-7-19-16/h1-4,7,9,11,21,24-25H,5-6H2,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315514
PNG
(US10172858, Table 2.10 | US9828378, # 10)
Show SMILES COc1cccc2cc([nH]c12)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-13(16(18)19-8-20-17)15(22-23)11-7-10-5-4-6-12(24-3)14(10)21-11/h4-9,21H,1-3H3,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315560
PNG
(US10172858, Table 2.57 | US9828378, # 57)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H27N7O2/c24-22-20-21(19-12-14-11-17(31)5-6-18(14)27-19)28-30(23(20)26-13-25-22)16-3-1-15(2-4-16)29-7-9-32-10-8-29/h5-6,11-13,15-16,27,31H,1-4,7-10H2,(H2,24,25,26)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM315568
PNG
(US10172858, Table 2.65 | US9828378, # 65)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3ccc(O)cc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H21N7O2/c1-11(28)26-6-4-13(5-7-26)27-20-17(19(21)22-10-23-20)18(25-27)16-8-12-2-3-14(29)9-15(12)24-16/h2-3,8-10,13,24,29H,4-7H2,1H3,(H2,21,22,23)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315566
PNG
(US10172858, Table 2.63 | US9828378, # 63)
Show SMILES COc1cccc2cc([nH]c12)-c1nn(C2CCOCC2)c2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O2/c1-26-14-4-2-3-11-9-13(23-16(11)14)17-15-18(20)21-10-22-19(15)25(24-17)12-5-7-27-8-6-12/h2-4,9-10,12,23H,5-8H2,1H3,(H2,20,21,22)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315535
PNG
(US10172858, Table 2.30 | US9828378, # 30)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H21N7O2/c1-11(28)26-6-4-13(5-7-26)27-20-17(19(21)22-10-23-20)18(25-27)16-9-12-8-14(29)2-3-15(12)24-16/h2-3,8-10,13,24,29H,4-7H2,1H3,(H2,21,22,23)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315536
PNG
(US10172858, Table 2.31 | US9828378, # 31)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C22H23N7O2/c23-20-18-19(17-10-13-9-15(30)3-4-16(13)26-17)27-29(21(18)25-11-24-20)14-5-7-28(8-6-14)22(31)12-1-2-12/h3-4,9-12,14,26,30H,1-2,5-8H2,(H2,23,24,25)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315564
PNG
(US10172858, Table 2.61 | US9828378, # 61)
Show SMILES COc1ccc(Cl)c2cc([nH]c12)-c1nn(C2CCOCC2)c2ncnc(N)c12
Show InChI InChI=1S/C19H19ClN6O2/c1-27-14-3-2-12(20)11-8-13(24-16(11)14)17-15-18(21)22-9-23-19(15)26(25-17)10-4-6-28-7-5-10/h2-3,8-10,24H,4-7H2,1H3,(H2,21,22,23)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM315566
PNG
(US10172858, Table 2.63 | US9828378, # 63)
Show SMILES COc1cccc2cc([nH]c12)-c1nn(C2CCOCC2)c2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O2/c1-26-14-4-2-3-11-9-13(23-16(11)14)17-15-18(20)21-10-22-19(15)25(24-17)12-5-7-27-8-6-12/h2-4,9-10,12,23H,5-8H2,1H3,(H2,20,21,22)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315525
PNG
(US10172858, Table 2.21 | US9828378, # 21)
Show SMILES CC(C)n1nc(-c2cc3ccc(O)cc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-5-9-3-4-10(23)6-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM36409
PNG
(2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315551
PNG
(US10172858, Table 2.48 | US9828378, # 48)
Show SMILES Nc1ncnc2n(nc(-c3cc4c(Cl)cccc4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H17ClN6O/c19-12-2-1-3-13-11(12)8-14(23-13)16-15-17(20)21-9-22-18(15)25(24-16)10-4-6-26-7-5-10/h1-3,8-10,23H,4-7H2,(H2,20,21,22)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM315572
PNG
(US10172858, Table 2.68 | US9828378, # 68)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)cc(Cl)c4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H17ClN6O2/c19-12-7-11(26)5-9-6-13(23-15(9)12)16-14-17(20)21-8-22-18(14)25(24-16)10-1-3-27-4-2-10/h5-8,10,23,26H,1-4H2,(H2,20,21,22)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315519
PNG
(US10172858, Table 2.15 | US9828378, # 15)
Show SMILES CC(C)n1nc(-c2cc3cc(O)cc(Cl)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6O/c1-7(2)23-16-12(15(18)19-6-20-16)14(22-23)11-4-8-3-9(24)5-10(17)13(8)21-11/h3-7,21,24H,1-2H3,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM315519
PNG
(US10172858, Table 2.15 | US9828378, # 15)
Show SMILES CC(C)n1nc(-c2cc3cc(O)cc(Cl)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6O/c1-7(2)23-16-12(15(18)19-6-20-16)14(22-23)11-4-8-3-9(24)5-10(17)13(8)21-11/h3-7,21,24H,1-2H3,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM50383382
PNG
(CHEMBL2030556 | CHEMBL2069948 | US10172858, Table ...)
Show SMILES CC(C)n1nc(-c2cc3c(Cl)cccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-16-13(15(18)19-7-20-16)14(22-23)12-6-9-10(17)4-3-5-11(9)21-12/h3-8,21H,1-2H3,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM315568
PNG
(US10172858, Table 2.65 | US9828378, # 65)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3ccc(O)cc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H21N7O2/c1-11(28)26-6-4-13(5-7-26)27-20-17(19(21)22-10-23-20)18(25-27)16-8-12-2-3-14(29)9-15(12)24-16/h2-3,8-10,13,24,29H,4-7H2,1H3,(H2,21,22,23)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315554
PNG
(US10172858, Table 2.51 | US9828378, # 51)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccc(Cl)c4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H17ClN6O/c19-12-3-1-2-10-8-13(23-15(10)12)16-14-17(20)21-9-22-18(14)25(24-16)11-4-6-26-7-5-11/h1-3,8-9,11,23H,4-7H2,(H2,20,21,22)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315553
PNG
(US10172858, Table 2.50 | US9828378, # 50)
Show SMILES CC(C)n1nc(-c2cc3cccc(Cl)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-16-12(15(18)19-7-20-16)14(22-23)11-6-9-4-3-5-10(17)13(9)21-11/h3-8,21H,1-2H3,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM315546
PNG
(US10172858, Table 2.41 | US9828378, # 41)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccc(O)c4[nH]3)c12)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C22H23N7O2/c23-20-17-19(15-10-13-2-1-3-16(30)18(13)26-15)27-29(21(17)25-11-24-20)14-6-8-28(9-7-14)22(31)12-4-5-12/h1-3,10-12,14,26,30H,4-9H2,(H2,23,24,25)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM315574
PNG
(US10172858, Table 2.70 | US9828378, # 70)
Show SMILES CC(=O)N1CCC(CC1)n1nc(-c2cc3cc(O)cc(Cl)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O2/c1-10(29)27-4-2-12(3-5-27)28-20-16(19(22)23-9-24-20)18(26-28)15-7-11-6-13(30)8-14(21)17(11)25-15/h6-9,12,25,30H,2-5H2,1H3,(H2,22,23,24)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315547
PNG
(US10172858, Table 2.42 | US9828378, # 42)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H18N6O2/c19-17-15-16(14-8-10-7-12(25)1-2-13(10)22-14)23-24(18(15)21-9-20-17)11-3-5-26-6-4-11/h1-2,7-9,11,22,25H,3-6H2,(H2,19,20,21)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315545
PNG
(US10172858, Table 2.40 | US9828378, # 40)
Show SMILES COCCn1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6O2/c1-24-5-4-22-16-13(15(17)18-8-19-16)14(21-22)12-7-9-6-10(23)2-3-11(9)20-12/h2-3,6-8,20,23H,4-5H2,1H3,(H2,17,18,19)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Cytosolic arginine sensor for mTORC1 subunit 1


(Homo sapiens (Human))
BDBM315556
PNG
(US10172858, Table 2.53 | US9828378, # 53)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CC(=O)C1
Show InChI InChI=1S/C17H14N6O2/c18-16-14-15(13-4-8-3-10(24)1-2-12(8)21-13)22-23(9-5-11(25)6-9)17(14)20-7-19-16/h1-4,7,9,21,24H,5-6H2,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315531
PNG
(US10172858, Table 2.26 | US9828378, # 26)
Show SMILES Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCCCC1
Show InChI InChI=1S/C19H20N6O/c20-18-16-17(15-9-11-8-13(26)6-7-14(11)23-15)24-25(19(16)22-10-21-18)12-4-2-1-3-5-12/h6-10,12,23,26H,1-5H2,(H2,20,21,22)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315565
PNG
(US10172858, Table 2.62 | US9828378, # 62)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccc(O)c4[nH]3)c12)C1CCOCC1
Show InChI InChI=1S/C18H18N6O2/c19-17-14-16(12-8-10-2-1-3-13(25)15(10)22-12)23-24(18(14)21-9-20-17)11-4-6-26-7-5-11/h1-3,8-9,11,22,25H,4-7H2,(H2,19,20,21)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM315520
PNG
(US10172858, Table 2.16 | US9828378, # 16)
Show SMILES CC(C)n1nc(-c2cc3cc(O)cc(F)c3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15FN6O/c1-7(2)23-16-12(15(18)19-6-20-16)14(22-23)11-4-8-3-9(24)5-10(17)13(8)21-11/h3-7,21,24H,1-2H3,(H2,18,19,20)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...


US Patent US9828378 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 257 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%