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Patent code US9834564

Compile Data Set for Download or QSAR

Found 209 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362594
PNG
(US9834564, Compound 154)
Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c1ccc1cccnc21
Show InChI InChI=1S/C21H17N5/c1-26-18-10-8-14-5-4-12-22-20(14)21(18)25-19(26)11-9-15-13-23-16-6-2-3-7-17(16)24-15/h2-8,10,12-13H,9,11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362595
PNG
(US9834564, Compound 155)
Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1cccnc21
Show InChI InChI=1S/C22H18N4/c1-26-19-12-9-16-6-4-14-23-21(16)22(19)25-20(26)13-11-17-10-8-15-5-2-3-7-18(15)24-17/h2-10,12,14H,11,13H2,1H3
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362598
PNG
(US9834564, Compound 158)
Show SMILES C(Cc1cnc2ccccc2n1)c1ccc2ccc3cccnc3c2n1
Show InChI InChI=1S/C22H16N4/c1-2-6-20-19(5-1)24-14-18(25-20)12-11-17-10-9-16-8-7-15-4-3-13-23-21(15)22(16)26-17/h1-10,13-14H,11-12H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362460
PNG
(US9834564, Compound 20)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1
Show InChI InChI=1S/C20H18N4/c1-24-14-19(15-7-3-2-4-8-15)23-20(24)12-11-16-13-21-17-9-5-6-10-18(17)22-16/h2-10,13-14H,11-12H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362526
PNG
(US9834564, Compound 86)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c(ccc3ncccc23)[nH]1
Show InChI InChI=1S/C21H16N4/c1-2-6-17-14(4-1)7-8-15(23-17)9-12-20-24-19-11-10-18-16(21(19)25-20)5-3-13-22-18/h1-8,10-11,13H,9,12H2,(H,24,25)
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362560
PNG
(US9834564, Compound 120)
Show SMILES C(Oc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C18H14N4O/c1-2-6-13(7-3-1)16-10-20-17(21-16)12-23-18-11-19-14-8-4-5-9-15(14)22-18/h1-11H,12H2,(H,20,21)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362571
PNG
(US9834564, Compound 131)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccc(F)c(F)c4n3)nc12
Show InChI InChI=1S/C18H15F2N5/c1-10-9-21-11(2)18-23-15(24-25(10)18)8-6-13-5-3-12-4-7-14(19)16(20)17(12)22-13/h3-5,7,9H,6,8H2,1-2H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362581
PNG
(US9834564, Compound 141)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccc5nccnc5c4n3)nc12
Show InChI InChI=1S/C20H17N7/c1-12-11-23-13(2)20-25-17(26-27(12)20)8-6-15-5-3-14-4-7-16-19(18(14)24-15)22-10-9-21-16/h3-5,7,9-11H,6,8H2,1-2H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362599
PNG
(US9834564, Compound 159)
Show SMILES C(Cc1ccc2ccc3cccnc3c2n1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H17N3/c1-2-6-21-16(4-1)9-11-19(25-21)13-14-20-12-10-18-8-7-17-5-3-15-24-22(17)23(18)26-20/h1-12,15H,13-14H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362605
PNG
(US9834564, Compound 165)
Show SMILES Cc1cnc(C)c2ccc(CCc3nc4c(ccc5ncccc45)n3C)nc12
Show InChI InChI=1S/C23H21N5/c1-14-13-25-15(2)17-8-6-16(26-22(14)17)7-11-21-27-23-18-5-4-12-24-19(18)9-10-20(23)28(21)3/h4-6,8-10,12-13H,7,11H2,1-3H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362619
PNG
(US9834564, Compound 181)
Show SMILES Fc1cnc2nc(CCc3nc4c5cccnc5ccn4n3)ccc2c1
Show InChI InChI=1S/C19H13FN6/c20-13-10-12-3-4-14(23-18(12)22-11-13)5-6-17-24-19-15-2-1-8-21-16(15)7-9-26(19)25-17/h1-4,7-11H,5-6H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362625
PNG
(US9834564, Compound 187)
Show SMILES Cc1c(CCc2ccc3nccc(C)c3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C22H19N5/c1-14-9-12-24-20-8-6-16(25-21(14)20)5-7-18-15(2)27-13-10-19-17(22(27)26-18)4-3-11-23-19/h3-4,6,8-13H,5,7H2,1-2H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362628
PNG
(US9834564, Compound 190)
Show SMILES Cc1c(CCc2cnc3ccccc3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C21H17N5/c1-14-17(9-8-15-13-23-19-6-2-3-7-20(19)24-15)25-21-16-5-4-11-22-18(16)10-12-26(14)21/h2-7,10-13H,8-9H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362648
PNG
(US9834564, Compound 210)
Show SMILES Cc1nc(CCc2nc3c(ccc4ncccc34)n2C)nc2CCCc12
Show InChI InChI=1S/C21H21N5/c1-13-14-5-3-7-17(14)24-19(23-13)10-11-20-25-21-15-6-4-12-22-16(15)8-9-18(21)26(20)2/h4,6,8-9,12H,3,5,7,10-11H2,1-2H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362429
PNG
(US9834564, Compound 2)
Show SMILES O=c1[nH]c2ccccc2nc1CCc1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C19H16N4O/c24-19-16(21-14-8-4-5-9-15(14)23-19)10-11-18-20-12-17(22-18)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22)(H,23,24)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362431
PNG
(US9834564, Compound 4)
Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2cnccc12
Show InChI InChI=1S/C18H15N5O/c24-18-13-8-9-19-10-15(13)22-17(23-18)7-6-16-20-11-14(21-16)12-4-2-1-3-5-12/h1-5,8-11H,6-7H2,(H,20,21)(H,22,23,24)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362446
PNG
(US9834564, Compound 13)
Show SMILES C(Cc1ncc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C19H16N4/c1-2-6-14(7-3-1)17-13-21-19(23-17)11-10-18-20-12-15-8-4-5-9-16(15)22-18/h1-9,12-13H,10-11H2,(H,21,23)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362479
PNG
(US9834564, Compound 39)
Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccco1
Show InChI InChI=1S/C19H17N3O/c1-22-13-17(18-7-4-12-23-18)21-19(22)11-10-15-9-8-14-5-2-3-6-16(14)20-15/h2-9,12-13H,10-11H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362488
PNG
(US9834564, Compound 48)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1F
Show InChI InChI=1S/C20H17FN4/c1-25-13-19(15-6-2-3-7-16(15)21)24-20(25)11-10-14-12-22-17-8-4-5-9-18(17)23-14/h2-9,12-13H,10-11H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362492
PNG
(US9834564, Compound 52)
Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccco2)nc2ccccc12
Show InChI InChI=1S/C17H14N4O2/c22-17-11-4-1-2-5-12(11)19-16(21-17)8-7-15-18-10-13(20-15)14-6-3-9-23-14/h1-6,9-10H,7-8H2,(H,18,20)(H,19,21,22)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362525
PNG
(US9834564, Compound 85)
Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C22H18N4/c1-26-20-12-11-19-17(6-4-14-23-19)22(20)25-21(26)13-10-16-9-8-15-5-2-3-7-18(15)24-16/h2-9,11-12,14H,10,13H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362530
PNG
(US9834564, Compound 90)
Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1ccccc21
Show InChI InChI=1S/C23H19N3/c1-26-21-14-11-16-6-2-4-8-19(16)23(21)25-22(26)15-13-18-12-10-17-7-3-5-9-20(17)24-18/h2-12,14H,13,15H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362543
PNG
(US9834564, Compound 103)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2c(ccc3ccccc23)[nH]1
Show InChI InChI=1S/C21H16N4/c1-2-6-16-14(5-1)9-11-19-21(16)25-20(24-19)12-10-15-13-22-17-7-3-4-8-18(17)23-15/h1-9,11,13H,10,12H2,(H,24,25)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM197734
PNG
(BDBM197735 | US9216986, 2-[2-(5,8-Dimethyl-[1,2,4]...)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12
Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)18-21-17(22-23(12)18)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362575
PNG
(US9834564, Compound 135)
Show SMILES Cc1ccc2ncc(CCc3nc4c(C)ncc(C)n4n3)nc2c1C
Show InChI InChI=1S/C19H20N6/c1-11-5-7-16-18(13(11)3)22-15(10-21-16)6-8-17-23-19-14(4)20-9-12(2)25(19)24-17/h5,7,9-10H,6,8H2,1-4H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362587
PNG
(US9834564, Compound 147)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c3cccnc3ccn2n1
Show InChI InChI=1S/C20H15N5/c1-2-6-17-14(4-1)7-8-15(22-17)9-10-19-23-20-16-5-3-12-21-18(16)11-13-25(20)24-19/h1-8,11-13H,9-10H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362597
PNG
(US9834564, Compound 157)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2c3ncccc3ccn2n1
Show InChI InChI=1S/C19H14N6/c1-2-6-16-15(5-1)21-12-14(22-16)7-8-17-23-19-18-13(4-3-10-20-18)9-11-25(19)24-17/h1-6,9-12H,7-8H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362606
PNG
(US9834564, Compound 166)
Show SMILES Cc1cnc(C)c2ccc(CCc3nc4c(ccc5ncccc45)[nH]3)nc12
Show InChI InChI=1S/C22H19N5/c1-13-12-24-14(2)16-7-5-15(25-21(13)16)6-10-20-26-19-9-8-18-17(22(19)27-20)4-3-11-23-18/h3-5,7-9,11-12H,6,10H2,1-2H3,(H,26,27)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362616
PNG
(US9834564, Compound 176)
Show SMILES C(Cc1ccc2ncccc2n1)c1nc2c3cccnc3ccn2n1
Show InChI InChI=1S/C19H14N6/c1-3-14-15(20-10-1)9-12-25-19(14)23-18(24-25)8-6-13-5-7-16-17(22-13)4-2-11-21-16/h1-5,7,9-12H,6,8H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362622
PNG
(US9834564, Compound 184)
Show SMILES Cc1c(CCc2ccc3cc(C)cnc3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C22H19N5/c1-14-12-16-5-6-17(25-21(16)24-13-14)7-8-19-15(2)27-11-9-20-18(22(27)26-19)4-3-10-23-20/h3-6,9-13H,7-8H2,1-2H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362626
PNG
(US9834564, Compound 188)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2c3cccnc3ccn2n1
Show InChI InChI=1S/C19H14N6/c1-2-6-17-16(5-1)21-12-13(22-17)7-8-18-23-19-14-4-3-10-20-15(14)9-11-25(19)24-18/h1-6,9-12H,7-8H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362630
PNG
(US9834564, Compound 192)
Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c3CCCNc3ccc12
Show InChI InChI=1S/C21H21N5/c1-26-19-10-9-16-15(5-4-12-22-16)21(19)25-20(26)11-8-14-13-23-17-6-2-3-7-18(17)24-14/h2-3,6-7,9-10,13,22H,4-5,8,11-12H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362632
PNG
(US9834564, Compound 194)
Show SMILES Cn1c(CCc2nc(cc(n2)C(F)(F)F)C(F)(F)F)nc2c1ccc1ncccc21
Show InChI InChI=1S/C19H13F6N5/c1-30-12-5-4-11-10(3-2-8-26-11)17(12)29-16(30)7-6-15-27-13(18(20,21)22)9-14(28-15)19(23,24)25/h2-5,8-9H,6-7H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362637
PNG
(US9834564, Compound 199)
Show SMILES C(Cc1ccc2ncccc2n1)c1cn2ccc3ncccc3c2n1
Show InChI InChI=1S/C20H15N5/c1-3-16-17(21-10-1)9-12-25-13-15(24-20(16)25)6-5-14-7-8-18-19(23-14)4-2-11-22-18/h1-4,7-13H,5-6H2
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362639
PNG
(US9834564, Compound 201)
Show SMILES Cc1c(CCc2ccc3ncccc3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C21H17N5/c1-14-17(8-6-15-7-9-19-20(24-15)5-3-12-23-19)25-21-16-4-2-11-22-18(16)10-13-26(14)21/h2-5,7,9-13H,6,8H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362640
PNG
(US9834564, Compound 202)
Show SMILES Cc1c(CCc2ccc3nc(C)ccc3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C22H19N5/c1-14-5-8-21-20(24-14)10-7-16(25-21)6-9-18-15(2)27-13-11-19-17(22(27)26-18)4-3-12-23-19/h3-5,7-8,10-13H,6,9H2,1-2H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50003991
PNG
(CHEMBL2180008 | US9834564, Compound 204)
Show SMILES Cn1c(CCc2ccc3ncccc3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C21H17N5/c1-26-19-10-9-16-15(4-2-12-22-16)21(19)25-20(26)11-7-14-6-8-17-18(24-14)5-3-13-23-17/h2-6,8-10,12-13H,7,11H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362445
PNG
(US9834564, Compound 12)
Show SMILES C(=C/c1ncc2ccccc2n1)\c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C19H14N4/c1-2-6-14(7-3-1)17-13-21-19(23-17)11-10-18-20-12-15-8-4-5-9-16(15)22-18/h1-13H,(H,21,23)/b11-10+
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362474
PNG
(US9834564, Compound 34)
Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)cc2ccccc12
Show InChI InChI=1S/C20H17N3O/c24-20-17-9-5-4-8-15(17)12-16(22-20)10-11-19-21-13-18(23-19)14-6-2-1-3-7-14/h1-9,12-13H,10-11H2,(H,21,23)(H,22,24)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362482
PNG
(US9834564, Compound 42)
Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccccc1F
Show InChI InChI=1S/C21H18FN3/c1-25-14-20(17-7-3-4-8-18(17)22)24-21(25)13-12-16-11-10-15-6-2-5-9-19(15)23-16/h2-11,14H,12-13H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362485
PNG
(US9834564, Compound 45)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccco1
Show InChI InChI=1S/C18H16N4O/c1-22-12-16(17-7-4-10-23-17)21-18(22)9-8-13-11-19-14-5-2-3-6-15(14)20-13/h2-7,10-12H,8-9H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362486
PNG
(US9834564, Compound 46)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccsc1
Show InChI InChI=1S/C18H16N4S/c1-22-11-17(13-8-9-23-12-13)21-18(22)7-6-14-10-19-15-4-2-3-5-16(15)20-14/h2-5,8-12H,6-7H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362490
PNG
(US9834564, Compound 50)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1cccc(F)c1F
Show InChI InChI=1S/C20H16F2N4/c1-26-12-18(14-5-4-6-15(21)20(14)22)25-19(26)10-9-13-11-23-16-7-2-3-8-17(16)24-13/h2-8,11-12H,9-10H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362491
PNG
(US9834564, Compound 51)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1cccnc1
Show InChI InChI=1S/C19H17N5/c1-24-13-18(14-5-4-10-20-11-14)23-19(24)9-8-15-12-21-16-6-2-3-7-17(16)22-15/h2-7,10-13H,8-9H2,1H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362512
PNG
(US9834564, Compound 72)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccco1
Show InChI InChI=1S/C17H14N4O/c1-2-5-14-13(4-1)18-10-12(20-14)7-8-17-19-11-15(21-17)16-6-3-9-22-16/h1-6,9-11H,7-8H2,(H,19,21)
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362518
PNG
(US9834564, Compound 78)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1cccnc1
Show InChI InChI=1S/C18H15N5/c1-2-6-16-15(5-1)20-11-14(22-16)7-8-18-21-12-17(23-18)13-4-3-9-19-10-13/h1-6,9-12H,7-8H2,(H,21,23)
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362527
PNG
(US9834564, Compound 87)
Show SMILES Cc1ccc(C)c2nc(CCc3nc4c(ccc5ncccc45)[nH]3)cnc12
Show InChI InChI=1S/C22H19N5/c1-13-5-6-14(2)21-20(13)24-12-15(25-21)7-10-19-26-18-9-8-17-16(22(18)27-19)4-3-11-23-17/h3-6,8-9,11-12H,7,10H2,1-2H3,(H,26,27)
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362532
PNG
(US9834564, Compound 92)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C17H14N4/c1-2-6-14-13(5-1)18-11-12(19-14)9-10-17-20-15-7-3-4-8-16(15)21-17/h1-8,11H,9-10H2,(H,20,21)
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362568
PNG
(US9834564, Compound 128)
Show SMILES Cc1ccc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2c1C
Show InChI InChI=1S/C20H21N5/c1-12-5-6-16-7-8-17(22-19(16)14(12)3)9-10-18-23-20-15(4)21-11-13(2)25(20)24-18/h5-8,11H,9-10H2,1-4H3
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM362578
PNG
(US9834564, Compound 138)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4cccnc4n3)nc12
Show InChI InChI=1S/C17H16N6/c1-11-10-19-12(2)17-21-15(22-23(11)17)8-7-14-6-5-13-4-3-9-18-16(13)20-14/h3-6,9-10H,7-8H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...


US Patent US9834564 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%