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Patent code US9840498

Compile Data Set for Download or QSAR
Found 95 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362702
PNG
(US9840498, 29)
Show SMILES CCOc1ncc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26FN9O3/c1-3-43-30-34-13-17(14-35-30)24-21(31)9-10-22-25(24)28(42)40(18-7-5-4-6-8-18)27(37-22)23-11-19(41)15-39(23)26-20(12-32)16(2)36-29(33)38-26/h4-10,13-14,19,23,41H,3,11,15H2,1-2H3,(H2,33,36,38)/t19-,23-/s2
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n/an/a 4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362679
PNG
(US9840498, 5)
Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H22FN9O/c1-35-14-16(13-33-35)22-19(28)9-10-20-23(22)27(38)37(17-6-3-2-4-7-17)26(34-20)21-8-5-11-36(21)25-18(12-29)24(30)31-15-32-25/h2-4,6-7,9-10,13-15,21H,5,8,11H2,1H3,(H2,30,31,32)/t21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362698
PNG
(US9840498, 25)
Show SMILES COc1cncc(c1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O3/c1-17-23(13-31)27(36-30(32)34-17)37-16-20(39)12-25(37)28-35-24-10-6-9-22(18-11-21(41-2)15-33-14-18)26(24)29(40)38(28)19-7-4-3-5-8-19/h3-11,14-15,20,25,39H,12,16H2,1-2H3,(H2,32,34,36)/t20-,25-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362696
PNG
(US9840498, 22)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O3/c1-16-21(12-30)25(36-28(31)34-16)37-15-19(39)11-23(37)26-35-22-10-6-9-20(17-13-32-29(41-2)33-14-17)24(22)27(40)38(26)18-7-4-3-5-8-18/h3-10,13-14,19,23,39H,11,15H2,1-2H3,(H2,31,34,36)/t19-,23-/s2
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n/an/a 5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362686
PNG
(US9840498, 12)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc(C)c1C#N)c1nc2cccc(-c3cnc(OC)nc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H27N9O3/c1-17-22(13-31)26(37-29(32)35-17)38-16-20(41-2)12-24(38)27-36-23-11-7-10-21(18-14-33-30(42-3)34-15-18)25(23)28(40)39(27)19-8-5-4-6-9-19/h4-11,14-15,20,24H,12,16H2,1-3H3,(H2,32,35,37)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362697
PNG
(US9840498, 24)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cccnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H24N8O2/c1-17-22(14-30)26(35-29(31)33-17)36-16-20(38)13-24(36)27-34-23-11-5-10-21(18-7-6-12-32-15-18)25(23)28(39)37(27)19-8-3-2-4-9-19/h2-12,15,20,24,38H,13,16H2,1H3,(H2,31,33,35)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362705
PNG
(US9840498, 32)
Show SMILES CCOc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H27N9O2/c1-3-41-30-33-16-19(17-34-30)21-11-7-12-23-25(21)28(40)39(20-9-5-4-6-10-20)27(36-23)24-13-8-14-38(24)26-22(15-31)18(2)35-29(32)37-26/h4-7,9-12,16-17,24H,3,8,13-14H2,1-2H3,(H2,32,35,37)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362699
PNG
(US9840498, 26)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cncnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H23N9O2/c1-16-21(11-29)25(35-28(30)33-16)36-14-19(38)10-23(36)26-34-22-9-5-8-20(17-12-31-15-32-13-17)24(22)27(39)37(26)18-6-3-2-4-7-18/h2-9,12-13,15,19,23,38H,10,14H2,1H3,(H2,30,33,35)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362681
PNG
(US9840498, 7)
Show SMILES COc1ncc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H24FN9O3/c1-15-19(11-31)25(37-28(32)35-15)38-14-18(40)10-22(38)26-36-21-9-8-20(30)23(16-12-33-29(42-2)34-13-16)24(21)27(41)39(26)17-6-4-3-5-7-17/h3-9,12-13,18,22,40H,10,14H2,1-2H3,(H2,32,35,37)/t18-,22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362684
PNG
(US9840498, 10)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc(C)c1C#N)c1nc2cccc(-c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H27N9O2/c1-17-22(13-30)26(35-29(31)33-17)37-16-20(40-3)12-24(37)27-34-23-11-7-10-21(18-14-32-36(2)15-18)25(23)28(39)38(27)19-8-5-4-6-9-19/h4-11,14-15,20,24H,12,16H2,1-3H3,(H2,31,33,35)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362678
PNG
(US9840498, 4)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O2/c1-17-21(14-30)25(36-28(31)34-17)37-13-7-12-23(37)26-35-22-11-6-10-20(18-15-32-29(40-2)33-16-18)24(22)27(39)38(26)19-8-4-3-5-9-19/h3-6,8-11,15-16,23H,7,12-13H2,1-2H3,(H2,31,34,36)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362690
PNG
(US9840498, 16)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H25N9O2/c1-16-21(12-29)25(34-28(30)32-16)36-15-19(38)11-23(36)26-33-22-10-6-9-20(17-13-31-35(2)14-17)24(22)27(39)37(26)18-7-4-3-5-8-18/h3-10,13-14,19,23,38H,11,15H2,1-2H3,(H2,30,32,34)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362687
PNG
(US9840498, 13)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-21(14-29)25(34-28(30)32-17)36-13-7-12-23(36)26-33-22-11-6-10-20(18-15-31-35(2)16-18)24(22)27(38)37(26)19-8-4-3-5-9-19/h3-6,8-11,15-16,23H,7,12-13H2,1-2H3,(H2,30,32,34)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362683
PNG
(US9840498, 9)
Show SMILES COc1ncc(s1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H23FN8O3S/c1-14-17(11-30)24(35-27(31)33-14)36-13-16(38)10-20(36)25-34-19-9-8-18(29)22(21-12-32-28(40-2)41-21)23(19)26(39)37(25)15-6-4-3-5-7-15/h3-9,12,16,20,38H,10,13H2,1-2H3,(H2,31,33,35)/t16-,20-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362675
PNG
(US9840498, 1)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3ccc(F)c(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1S/C28H24FN9O2/c1-15-19(11-30)25(35-28(31)33-15)37-14-18(39)10-22(37)26-34-21-9-8-20(29)23(16-12-32-36(2)13-16)24(21)27(40)38(26)17-6-4-3-5-7-17/h3-9,12-13,18,22,39H,10,14H2,1-2H3,(H2,31,33,35)/t18-,22-/m0/s1
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362677
PNG
(US9840498, 3)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H23N9O2/c1-39-28-31-14-17(15-32-28)19-9-5-10-21-23(19)27(38)37(18-7-3-2-4-8-18)26(35-21)22-11-6-12-36(22)25-20(13-29)24(30)33-16-34-25/h2-5,7-10,14-16,22H,6,11-12H2,1H3,(H2,30,33,34)/t22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362680
PNG
(US9840498, 6)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3ccc(F)c(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O/c1-16-19(13-30)25(35-28(31)33-16)37-12-6-9-22(37)26-34-21-11-10-20(29)23(17-14-32-36(2)15-17)24(21)27(39)38(26)18-7-4-3-5-8-18/h3-5,7-8,10-11,14-15,22H,6,9,12H2,1-2H3,(H2,31,33,35)/t22-/s2
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n/an/a 9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362701
PNG
(US9840498, 28)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cnn(CCO)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H27N9O3/c1-17-22(13-30)26(35-29(31)33-17)37-16-20(40)12-24(37)27-34-23-9-5-8-21(18-14-32-36(15-18)10-11-39)25(23)28(41)38(27)19-6-3-2-4-7-19/h2-9,14-15,20,24,39-40H,10-12,16H2,1H3,(H2,31,33,35)/t20-,24-/s2
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n/an/a 10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362700
PNG
(US9840498, 27)
Show SMILES COc1ccc(cn1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O3/c1-17-22(14-31)27(36-30(32)34-17)37-16-20(39)13-24(37)28-35-23-10-6-9-21(18-11-12-25(41-2)33-15-18)26(23)29(40)38(28)19-7-4-3-5-8-19/h3-12,15,20,24,39H,13,16H2,1-2H3,(H2,32,34,36)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362702
PNG
(US9840498, 29)
Show SMILES CCOc1ncc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26FN9O3/c1-3-43-30-34-13-17(14-35-30)24-21(31)9-10-22-25(24)28(42)40(18-7-5-4-6-8-18)27(37-22)23-11-19(41)15-39(23)26-20(12-32)16(2)36-29(33)38-26/h4-10,13-14,19,23,41H,3,11,15H2,1-2H3,(H2,33,36,38)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362704
PNG
(US9840498, 31)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3ccc(F)c(-c4cn(C)cn4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O2/c1-15-18(11-30)25(35-28(31)33-15)37-12-17(39)10-22(37)26-34-20-9-8-19(29)23(21-13-36(2)14-32-21)24(20)27(40)38(26)16-6-4-3-5-7-16/h3-9,13-14,17,22,39H,10,12H2,1-2H3,(H2,31,33,35)/t17-,22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362706
PNG
(US9840498, 33)
Show SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCO)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C26H21N7O2/c27-15-19-23(28)29-16-30-24(19)32-13-5-12-21(32)25-31-20-11-4-7-17(8-6-14-34)22(20)26(35)33(25)18-9-2-1-3-10-18/h1-4,7,9-11,16,21,34H,5,12-14H2,(H2,28,29,30)/t21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362703
PNG
(US9840498, 30)
Show SMILES Cc1nc(N)nc(N2C[C@@H](F)C[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O/c1-16-21(12-30)25(35-28(31)33-16)37-15-18(29)11-23(37)26-34-22-10-6-9-20(17-13-32-36(2)14-17)24(22)27(39)38(26)19-7-4-3-5-8-19/h3-10,13-14,18,23H,11,15H2,1-2H3,(H2,31,33,35)/t18-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362682
PNG
(US9840498, 8)
Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H22FN9O2/c1-35-12-15(11-33-35)22-19(28)7-8-20-23(22)27(39)37(16-5-3-2-4-6-16)26(34-20)21-9-17(38)13-36(21)25-18(10-29)24(30)31-14-32-25/h2-8,11-12,14,17,21,38H,9,13H2,1H3,(H2,30,31,32)/t17-,21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362692
PNG
(US9840498, 18)
Show SMILES COc1cncc(c1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O2/c1-18-23(15-31)27(36-30(32)34-18)37-13-7-12-25(37)28-35-24-11-6-10-22(19-14-21(40-2)17-33-16-19)26(24)29(39)38(28)20-8-4-3-5-9-20/h3-6,8-11,14,16-17,25H,7,12-13H2,1-2H3,(H2,32,34,36)/t25-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362694
PNG
(US9840498, 20)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cccnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H24N8O/c1-18-22(16-30)26(35-29(31)33-18)36-15-7-13-24(36)27-34-23-12-5-11-21(19-8-6-14-32-17-19)25(23)28(38)37(27)20-9-3-2-4-10-20/h2-6,8-12,14,17,24H,7,13,15H2,1H3,(H2,31,33,35)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362693
PNG
(US9840498, 19)
Show SMILES Cc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O/c1-17-22(14-30)26(36-29(31)34-17)37-13-7-12-24(37)27-35-23-11-6-10-21(19-15-32-18(2)33-16-19)25(23)28(39)38(27)20-8-4-3-5-9-20/h3-6,8-11,15-16,24H,7,12-13H2,1-2H3,(H2,31,34,36)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362683
PNG
(US9840498, 9)
Show SMILES COc1ncc(s1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H23FN8O3S/c1-14-17(11-30)24(35-27(31)33-14)36-13-16(38)10-20(36)25-34-19-9-8-18(29)22(21-12-32-28(40-2)41-21)23(19)26(39)37(25)15-6-4-3-5-7-15/h3-9,12,16,20,38H,10,13H2,1-2H3,(H2,31,33,35)/t16-,20-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362691
PNG
(US9840498, 17)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cncnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H23N9O/c1-17-21(13-29)25(35-28(30)33-17)36-12-6-11-23(36)26-34-22-10-5-9-20(18-14-31-16-32-15-18)24(22)27(38)37(26)19-7-3-2-4-8-19/h2-5,7-10,14-16,23H,6,11-12H2,1H3,(H2,30,33,35)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362701
PNG
(US9840498, 28)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cnn(CCO)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H27N9O3/c1-17-22(13-30)26(35-29(31)33-17)37-16-20(40)12-24(37)27-34-23-9-5-8-21(18-14-32-36(15-18)10-11-39)25(23)28(41)38(27)19-6-3-2-4-7-19/h2-9,14-15,20,24,39-40H,10-12,16H2,1H3,(H2,31,33,35)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362695
PNG
(US9840498, 21)
Show SMILES COc1ccc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O2/c1-18-22(16-31)27(36-30(32)34-18)37-15-7-12-24(37)28-35-23-11-6-10-21(19-13-14-25(40-2)33-17-19)26(23)29(39)38(28)20-8-4-3-5-9-20/h3-6,8-11,13-14,17,24H,7,12,15H2,1-2H3,(H2,32,34,36)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362703
PNG
(US9840498, 30)
Show SMILES Cc1nc(N)nc(N2C[C@@H](F)C[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O/c1-16-21(12-30)25(35-28(31)33-16)37-15-18(29)11-23(37)26-34-22-10-6-9-20(17-13-32-36(2)14-17)24(22)27(39)38(26)19-7-4-3-5-8-19/h3-10,13-14,18,23H,11,15H2,1-2H3,(H2,31,33,35)/t18-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362675
PNG
(US9840498, 1)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3ccc(F)c(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1S/C28H24FN9O2/c1-15-19(11-30)25(35-28(31)33-15)37-14-18(39)10-22(37)26-34-21-9-8-20(29)23(16-12-32-36(2)13-16)24(21)27(40)38(26)17-6-4-3-5-7-17/h3-9,12-13,18,22,39H,10,14H2,1-2H3,(H2,31,33,35)/t18-,22-/m0/s1
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362684
PNG
(US9840498, 10)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc(C)c1C#N)c1nc2cccc(-c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H27N9O2/c1-17-22(13-30)26(35-29(31)33-17)37-16-20(40-3)12-24(37)27-34-23-11-7-10-21(18-14-32-36(2)15-18)25(23)28(39)38(27)19-8-5-4-6-9-19/h4-11,14-15,20,24H,12,16H2,1-3H3,(H2,31,33,35)/t20-,24-/s2
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n/an/a 38n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362685
PNG
(US9840498, 11)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc2[nH]cnc12)c1nc2cccc(-c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C28H26N10O2/c1-36-13-16(12-32-36)19-9-6-10-20-22(19)27(39)38(17-7-4-3-5-8-17)25(33-20)21-11-18(40-2)14-37(21)26-23-24(31-15-30-23)34-28(29)35-26/h3-10,12-13,15,18,21H,11,14H2,1-2H3,(H3,29,30,31,34,35)/t18-,21-/s2
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n/an/a 45n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362690
PNG
(US9840498, 16)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H25N9O2/c1-16-21(12-29)25(34-28(30)32-16)36-15-19(38)11-23(36)26-33-22-10-6-9-20(17-13-31-35(2)14-17)24(22)27(39)37(26)18-7-4-3-5-8-18/h3-10,13-14,19,23,38H,11,15H2,1-2H3,(H2,30,32,34)/t19-,23-/s2
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n/an/a 48n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362698
PNG
(US9840498, 25)
Show SMILES COc1cncc(c1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O3/c1-17-23(13-31)27(36-30(32)34-17)37-16-20(39)12-25(37)28-35-24-10-6-9-22(18-11-21(41-2)15-33-14-18)26(24)29(40)38(28)19-7-4-3-5-8-19/h3-11,14-15,20,25,39H,12,16H2,1-2H3,(H2,32,34,36)/t20-,25-/s2
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n/an/a 48n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362683
PNG
(US9840498, 9)
Show SMILES COc1ncc(s1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H23FN8O3S/c1-14-17(11-30)24(35-27(31)33-14)36-13-16(38)10-20(36)25-34-19-9-8-18(29)22(21-12-32-28(40-2)41-21)23(19)26(39)37(25)15-6-4-3-5-7-15/h3-9,12,16,20,38H,10,13H2,1-2H3,(H2,31,33,35)/t16-,20-/s2
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n/an/a 53n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362680
PNG
(US9840498, 6)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3ccc(F)c(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O/c1-16-19(13-30)25(35-28(31)33-16)37-12-6-9-22(37)26-34-21-11-10-20(29)23(17-14-32-36(2)15-17)24(21)27(39)38(26)18-7-4-3-5-8-18/h3-5,7-8,10-11,14-15,22H,6,9,12H2,1-2H3,(H2,31,33,35)/t22-/s2
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n/an/a 56n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362692
PNG
(US9840498, 18)
Show SMILES COc1cncc(c1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O2/c1-18-23(15-31)27(36-30(32)34-18)37-13-7-12-25(37)28-35-24-11-6-10-22(19-14-21(40-2)17-33-16-19)26(24)29(39)38(28)20-8-4-3-5-9-20/h3-6,8-11,14,16-17,25H,7,12-13H2,1-2H3,(H2,32,34,36)/t25-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362700
PNG
(US9840498, 27)
Show SMILES COc1ccc(cn1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O3/c1-17-22(14-31)27(36-30(32)34-17)37-16-20(39)13-24(37)28-35-23-10-6-9-21(18-11-12-25(41-2)33-15-18)26(23)29(40)38(28)19-7-4-3-5-8-19/h3-12,15,20,24,39H,13,16H2,1-2H3,(H2,32,34,36)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362698
PNG
(US9840498, 25)
Show SMILES COc1cncc(c1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O3/c1-17-23(13-31)27(36-30(32)34-17)37-16-20(39)12-25(37)28-35-24-10-6-9-22(18-11-21(41-2)15-33-14-18)26(24)29(40)38(28)19-7-4-3-5-8-19/h3-11,14-15,20,25,39H,12,16H2,1-2H3,(H2,32,34,36)/t20-,25-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362675
PNG
(US9840498, 1)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3ccc(F)c(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1S/C28H24FN9O2/c1-15-19(11-30)25(35-28(31)33-15)37-14-18(39)10-22(37)26-34-21-9-8-20(29)23(16-12-32-36(2)13-16)24(21)27(40)38(26)17-6-4-3-5-7-17/h3-9,12-13,18,22,39H,10,14H2,1-2H3,(H2,31,33,35)/t18-,22-/m0/s1
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n/an/a 74n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362688
PNG
(US9840498, 14)
Show SMILES Cc1ccccc1-n1c(nc2cccc(-c3cnn(C)c3)c2c1=O)[C@@H]1CCCN1c1ncnc(N)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-7-3-4-10-22(17)37-27(23-11-6-12-36(23)26-20(13-29)25(30)31-16-32-26)34-21-9-5-8-19(24(21)28(37)38)18-14-33-35(2)15-18/h3-5,7-10,14-16,23H,6,11-12H2,1-2H3,(H2,30,31,32)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362706
PNG
(US9840498, 33)
Show SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCO)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C26H21N7O2/c27-15-19-23(28)29-16-30-24(19)32-13-5-12-21(32)25-31-20-11-4-7-17(8-6-14-34)22(20)26(35)33(25)18-9-2-1-3-10-18/h1-4,7,9-11,16,21,34H,5,12-14H2,(H2,28,29,30)/t21-/s2
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n/an/a 81n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362697
PNG
(US9840498, 24)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cccnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H24N8O2/c1-17-22(14-30)26(35-29(31)33-17)36-16-20(38)13-24(36)27-34-23-11-5-10-21(18-7-6-12-32-15-18)25(23)28(39)37(27)19-8-3-2-4-9-19/h2-12,15,20,24,38H,13,16H2,1H3,(H2,31,33,35)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362678
PNG
(US9840498, 4)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O2/c1-17-21(14-30)25(36-28(31)34-17)37-13-7-12-23(37)26-35-22-11-6-10-20(18-15-32-29(40-2)33-16-18)24(22)27(39)38(26)19-8-4-3-5-9-19/h3-6,8-11,15-16,23H,7,12-13H2,1-2H3,(H2,31,34,36)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362679
PNG
(US9840498, 5)
Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H22FN9O/c1-35-14-16(13-33-35)22-19(28)9-10-20-23(22)27(38)37(17-6-3-2-4-7-17)26(34-20)21-8-5-11-36(21)25-18(12-29)24(30)31-15-32-25/h2-4,6-7,9-10,13-15,21H,5,8,11H2,1H3,(H2,30,31,32)/t21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362700
PNG
(US9840498, 27)
Show SMILES COc1ccc(cn1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O3/c1-17-22(14-31)27(36-30(32)34-17)37-16-20(39)13-24(37)28-35-23-10-6-9-21(18-11-12-25(41-2)33-15-18)26(23)29(40)38(28)19-7-4-3-5-8-19/h3-12,15,20,24,39H,13,16H2,1-2H3,(H2,32,34,36)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362692
PNG
(US9840498, 18)
Show SMILES COc1cncc(c1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O2/c1-18-23(15-31)27(36-30(32)34-18)37-13-7-12-25(37)28-35-24-11-6-10-22(19-14-21(40-2)17-33-16-19)26(24)29(39)38(28)20-8-4-3-5-9-20/h3-6,8-11,14,16-17,25H,7,12-13H2,1-2H3,(H2,32,34,36)/t25-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362681
PNG
(US9840498, 7)
Show SMILES COc1ncc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H24FN9O3/c1-15-19(11-31)25(37-28(32)35-15)38-14-18(40)10-22(38)26-36-21-9-8-20(30)23(16-12-33-29(42-2)34-13-16)24(21)27(41)39(26)17-6-4-3-5-7-17/h3-9,12-13,18,22,40H,10,14H2,1-2H3,(H2,32,35,37)/t18-,22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362704
PNG
(US9840498, 31)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3ccc(F)c(-c4cn(C)cn4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O2/c1-15-18(11-30)25(35-28(31)33-15)37-12-17(39)10-22(37)26-34-20-9-8-19(29)23(21-13-36(2)14-32-21)24(20)27(40)38(26)16-6-4-3-5-7-16/h3-9,13-14,17,22,39H,10,12H2,1-2H3,(H2,31,33,35)/t17-,22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362687
PNG
(US9840498, 13)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-21(14-29)25(34-28(30)32-17)36-13-7-12-23(36)26-33-22-11-6-10-20(18-15-31-35(2)16-18)24(22)27(38)37(26)19-8-4-3-5-9-19/h3-6,8-11,15-16,23H,7,12-13H2,1-2H3,(H2,30,32,34)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362680
PNG
(US9840498, 6)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3ccc(F)c(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O/c1-16-19(13-30)25(35-28(31)33-16)37-12-6-9-22(37)26-34-21-11-10-20(29)23(17-14-32-36(2)15-17)24(21)27(39)38(26)18-7-4-3-5-8-18/h3-5,7-8,10-11,14-15,22H,6,9,12H2,1-2H3,(H2,31,33,35)/t22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362696
PNG
(US9840498, 22)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O3/c1-16-21(12-30)25(36-28(31)34-16)37-15-19(39)11-23(37)26-35-22-10-6-9-20(17-13-32-29(41-2)33-14-17)24(22)27(40)38(26)18-7-4-3-5-8-18/h3-10,13-14,19,23,39H,11,15H2,1-2H3,(H2,31,34,36)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362705
PNG
(US9840498, 32)
Show SMILES CCOc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H27N9O2/c1-3-41-30-33-16-19(17-34-30)21-11-7-12-23-25(21)28(40)39(20-9-5-4-6-10-20)27(36-23)24-13-8-14-38(24)26-22(15-31)18(2)35-29(32)37-26/h4-7,9-12,16-17,24H,3,8,13-14H2,1-2H3,(H2,32,35,37)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362694
PNG
(US9840498, 20)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cccnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H24N8O/c1-18-22(16-30)26(35-29(31)33-18)36-15-7-13-24(36)27-34-23-12-5-11-21(19-8-6-14-32-17-19)25(23)28(38)37(27)20-9-3-2-4-10-20/h2-6,8-12,14,17,24H,7,13,15H2,1H3,(H2,31,33,35)/t24-/s2
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US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362676
PNG
(US9840498, 2)
Show SMILES Cn1cc(cn1)-c1cccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H23N9O/c1-34-15-17(14-32-34)19-9-5-10-21-23(19)27(37)36(18-7-3-2-4-8-18)26(33-21)22-11-6-12-35(22)25-20(13-28)24(29)30-16-31-25/h2-5,7-10,14-16,22H,6,11-12H2,1H3,(H2,29,30,31)/t22-/s2
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US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362697
PNG
(US9840498, 24)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cccnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H24N8O2/c1-17-22(14-30)26(35-29(31)33-17)36-16-20(38)13-24(36)27-34-23-11-5-10-21(18-7-6-12-32-15-18)25(23)28(39)37(27)19-8-3-2-4-9-19/h2-12,15,20,24,38H,13,16H2,1H3,(H2,31,33,35)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362690
PNG
(US9840498, 16)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H25N9O2/c1-16-21(12-29)25(34-28(30)32-16)36-15-19(38)11-23(36)26-33-22-10-6-9-20(17-13-31-35(2)14-17)24(22)27(39)37(26)18-7-4-3-5-8-18/h3-10,13-14,19,23,38H,11,15H2,1-2H3,(H2,30,32,34)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362686
PNG
(US9840498, 12)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc(C)c1C#N)c1nc2cccc(-c3cnc(OC)nc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H27N9O3/c1-17-22(13-31)26(37-29(32)35-17)38-16-20(41-2)12-24(38)27-36-23-11-7-10-21(18-14-33-30(42-3)34-15-18)25(23)28(40)39(27)19-8-5-4-6-9-19/h4-11,14-15,20,24H,12,16H2,1-3H3,(H2,32,35,37)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362681
PNG
(US9840498, 7)
Show SMILES COc1ncc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H24FN9O3/c1-15-19(11-31)25(37-28(32)35-15)38-14-18(40)10-22(38)26-36-21-9-8-20(30)23(16-12-33-29(42-2)34-13-16)24(21)27(41)39(26)17-6-4-3-5-7-17/h3-9,12-13,18,22,40H,10,14H2,1-2H3,(H2,32,35,37)/t18-,22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362685
PNG
(US9840498, 11)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc2[nH]cnc12)c1nc2cccc(-c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C28H26N10O2/c1-36-13-16(12-32-36)19-9-6-10-20-22(19)27(39)38(17-7-4-3-5-8-17)25(33-20)21-11-18(40-2)14-37(21)26-23-24(31-15-30-23)34-28(29)35-26/h3-10,12-13,15,18,21H,11,14H2,1-2H3,(H3,29,30,31,34,35)/t18-,21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362679
PNG
(US9840498, 5)
Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H22FN9O/c1-35-14-16(13-33-35)22-19(28)9-10-20-23(22)27(38)37(17-6-3-2-4-7-17)26(34-20)21-8-5-11-36(21)25-18(12-29)24(30)31-15-32-25/h2-4,6-7,9-10,13-15,21H,5,8,11H2,1H3,(H2,30,31,32)/t21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362701
PNG
(US9840498, 28)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cnn(CCO)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H27N9O3/c1-17-22(13-30)26(35-29(31)33-17)37-16-20(40)12-24(37)27-34-23-9-5-8-21(18-14-32-36(15-18)10-11-39)25(23)28(41)38(27)19-6-3-2-4-7-19/h2-9,14-15,20,24,39-40H,10-12,16H2,1H3,(H2,31,33,35)/t20-,24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362694
PNG
(US9840498, 20)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cccnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C29H24N8O/c1-18-22(16-30)26(35-29(31)33-18)36-15-7-13-24(36)27-34-23-12-5-11-21(19-8-6-14-32-17-19)25(23)28(38)37(27)20-9-3-2-4-10-20/h2-6,8-12,14,17,24H,7,13,15H2,1H3,(H2,31,33,35)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362687
PNG
(US9840498, 13)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-21(14-29)25(34-28(30)32-17)36-13-7-12-23(36)26-33-22-11-6-10-20(18-15-31-35(2)16-18)24(22)27(38)37(26)19-8-4-3-5-9-19/h3-6,8-11,15-16,23H,7,12-13H2,1-2H3,(H2,30,32,34)/t23-/s2
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Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362695
PNG
(US9840498, 21)
Show SMILES COc1ccc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O2/c1-18-22(16-31)27(36-30(32)34-18)37-15-7-12-24(37)28-35-23-11-6-10-21(19-13-14-25(40-2)33-17-19)26(23)29(39)38(28)20-8-4-3-5-9-20/h3-6,8-11,13-14,17,24H,7,12,15H2,1-2H3,(H2,32,34,36)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362695
PNG
(US9840498, 21)
Show SMILES COc1ccc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26N8O2/c1-18-22(16-31)27(36-30(32)34-18)37-15-7-12-24(37)28-35-23-11-6-10-21(19-13-14-25(40-2)33-17-19)26(23)29(39)38(28)20-8-4-3-5-9-20/h3-6,8-11,13-14,17,24H,7,12,15H2,1-2H3,(H2,32,34,36)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362678
PNG
(US9840498, 4)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O2/c1-17-21(14-30)25(36-28(31)34-17)37-13-7-12-23(37)26-35-22-11-6-10-20(18-15-32-29(40-2)33-16-18)24(22)27(39)38(26)19-8-4-3-5-9-19/h3-6,8-11,15-16,23H,7,12-13H2,1-2H3,(H2,31,34,36)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362688
PNG
(US9840498, 14)
Show SMILES Cc1ccccc1-n1c(nc2cccc(-c3cnn(C)c3)c2c1=O)[C@@H]1CCCN1c1ncnc(N)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-7-3-4-10-22(17)37-27(23-11-6-12-36(23)26-20(13-29)25(30)31-16-32-26)34-21-9-5-8-19(24(21)28(37)38)18-14-33-35(2)15-18/h3-5,7-10,14-16,23H,6,11-12H2,1-2H3,(H2,30,31,32)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362702
PNG
(US9840498, 29)
Show SMILES CCOc1ncc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H26FN9O3/c1-3-43-30-34-13-17(14-35-30)24-21(31)9-10-22-25(24)28(42)40(18-7-5-4-6-8-18)27(37-22)23-11-19(41)15-39(23)26-20(12-32)16(2)36-29(33)38-26/h4-10,13-14,19,23,41H,3,11,15H2,1-2H3,(H2,33,36,38)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362693
PNG
(US9840498, 19)
Show SMILES Cc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O/c1-17-22(14-30)26(36-29(31)34-17)37-13-7-12-24(37)27-35-23-11-6-10-21(19-15-32-18(2)33-16-19)25(23)28(39)38(27)20-8-4-3-5-9-20/h3-6,8-11,15-16,24H,7,12-13H2,1-2H3,(H2,31,34,36)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362699
PNG
(US9840498, 26)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cncnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H23N9O2/c1-16-21(11-29)25(35-28(30)33-16)36-14-19(38)10-23(36)26-34-22-9-5-8-20(17-12-31-15-32-13-17)24(22)27(39)37(26)18-6-3-2-4-7-18/h2-9,12-13,15,19,23,38H,10,14H2,1H3,(H2,30,33,35)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362703
PNG
(US9840498, 30)
Show SMILES Cc1nc(N)nc(N2C[C@@H](F)C[C@H]2c2nc3cccc(-c4cnn(C)c4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O/c1-16-21(12-30)25(35-28(31)33-16)37-15-18(29)11-23(37)26-34-22-10-6-9-20(17-13-32-36(2)14-17)24(22)27(39)38(26)19-7-4-3-5-8-19/h3-10,13-14,18,23H,11,15H2,1-2H3,(H2,31,33,35)/t18-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362705
PNG
(US9840498, 32)
Show SMILES CCOc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C30H27N9O2/c1-3-41-30-33-16-19(17-34-30)21-11-7-12-23-25(21)28(40)39(20-9-5-4-6-10-20)27(36-23)24-13-8-14-38(24)26-22(15-31)18(2)35-29(32)37-26/h4-7,9-12,16-17,24H,3,8,13-14H2,1-2H3,(H2,32,35,37)/t24-/s2
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n/an/a 490n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362699
PNG
(US9840498, 26)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3cccc(-c4cncnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H23N9O2/c1-16-21(11-29)25(35-28(30)33-16)36-14-19(38)10-23(36)26-34-22-9-5-8-20(17-12-31-15-32-13-17)24(22)27(39)37(26)18-6-3-2-4-7-18/h2-9,12-13,15,19,23,38H,10,14H2,1H3,(H2,30,33,35)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362704
PNG
(US9840498, 31)
Show SMILES Cc1nc(N)nc(N2C[C@@H](O)C[C@H]2c2nc3ccc(F)c(-c4cn(C)cn4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H24FN9O2/c1-15-18(11-30)25(35-28(31)33-15)37-12-17(39)10-22(37)26-34-20-9-8-19(29)23(21-13-36(2)14-32-21)24(20)27(40)38(26)16-6-4-3-5-7-16/h3-9,13-14,17,22,39H,10,12H2,1-2H3,(H2,31,33,35)/t17-,22-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362696
PNG
(US9840498, 22)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3C[C@H](O)CN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O3/c1-16-21(12-30)25(36-28(31)34-16)37-15-19(39)11-23(37)26-35-22-10-6-9-20(17-13-32-29(41-2)33-14-17)24(22)27(40)38(26)18-7-4-3-5-8-18/h3-10,13-14,19,23,39H,11,15H2,1-2H3,(H2,31,34,36)/t19-,23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362706
PNG
(US9840498, 33)
Show SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCO)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C26H21N7O2/c27-15-19-23(28)29-16-30-24(19)32-13-5-12-21(32)25-31-20-11-4-7-17(8-6-14-34)22(20)26(35)33(25)18-9-2-1-3-10-18/h1-4,7,9-11,16,21,34H,5,12-14H2,(H2,28,29,30)/t21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362682
PNG
(US9840498, 8)
Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H22FN9O2/c1-35-12-15(11-33-35)22-19(28)7-8-20-23(22)27(39)37(16-5-3-2-4-6-16)26(34-20)21-9-17(38)13-36(21)25-18(10-29)24(30)31-14-32-25/h2-8,11-12,14,17,21,38H,9,13H2,1H3,(H2,30,31,32)/t17-,21-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362693
PNG
(US9840498, 19)
Show SMILES Cc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3nc(N)nc(C)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C29H25N9O/c1-17-22(14-30)26(36-29(31)34-17)37-13-7-12-24(37)27-35-23-11-6-10-21(19-15-32-18(2)33-16-19)25(23)28(39)38(27)20-8-4-3-5-9-20/h3-6,8-11,15-16,24H,7,12-13H2,1-2H3,(H2,31,34,36)/t24-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362688
PNG
(US9840498, 14)
Show SMILES Cc1ccccc1-n1c(nc2cccc(-c3cnn(C)c3)c2c1=O)[C@@H]1CCCN1c1ncnc(N)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-7-3-4-10-22(17)37-27(23-11-6-12-36(23)26-20(13-29)25(30)31-16-32-26)34-21-9-5-8-19(24(21)28(37)38)18-14-33-35(2)15-18/h3-5,7-10,14-16,23H,6,11-12H2,1-2H3,(H2,30,31,32)/t23-/s2
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362691
PNG
(US9840498, 17)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cncnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H23N9O/c1-17-21(13-29)25(35-28(30)33-17)36-12-6-11-23(36)26-34-22-10-5-9-20(18-14-31-16-32-15-18)24(22)27(38)37(26)19-7-3-2-4-8-19/h2-5,7-10,14-16,23H,6,11-12H2,1H3,(H2,30,33,35)/t23-/s2
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n/an/a 940n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362682
PNG
(US9840498, 8)
Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H22FN9O2/c1-35-12-15(11-33-35)22-19(28)7-8-20-23(22)27(39)37(16-5-3-2-4-6-16)26(34-20)21-9-17(38)13-36(21)25-18(10-29)24(30)31-14-32-25/h2-8,11-12,14,17,21,38H,9,13H2,1H3,(H2,30,31,32)/t17-,21-/s2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362677
PNG
(US9840498, 3)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H23N9O2/c1-39-28-31-14-17(15-32-28)19-9-5-10-21-23(19)27(38)37(18-7-3-2-4-8-18)26(35-21)22-11-6-12-36(22)25-20(13-29)24(30)33-16-34-25/h2-5,7-10,14-16,22H,6,11-12H2,1H3,(H2,30,33,34)/t22-/s2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362686
PNG
(US9840498, 12)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc(C)c1C#N)c1nc2cccc(-c3cnc(OC)nc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H27N9O3/c1-17-22(13-31)26(37-29(32)35-17)38-16-20(41-2)12-24(38)27-36-23-11-7-10-21(18-14-33-30(42-3)34-15-18)25(23)28(40)39(27)19-8-5-4-6-9-19/h4-11,14-15,20,24H,12,16H2,1-3H3,(H2,32,35,37)/t20-,24-/s2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362691
PNG
(US9840498, 17)
Show SMILES Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(-c4cncnc4)c3c(=O)n2-c2ccccc2)c1C#N
Show InChI InChI=1/C28H23N9O/c1-17-21(13-29)25(35-28(30)33-17)36-12-6-11-23(36)26-34-22-10-5-9-20(18-14-31-16-32-15-18)24(22)27(38)37(26)19-7-3-2-4-8-19/h2-5,7-10,14-16,23H,6,11-12H2,1H3,(H2,30,33,35)/t23-/s2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362676
PNG
(US9840498, 2)
Show SMILES Cn1cc(cn1)-c1cccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C27H23N9O/c1-34-15-17(14-32-34)19-9-5-10-21-23(19)27(37)36(18-7-3-2-4-8-18)26(33-21)22-11-6-12-35(22)25-20(13-28)24(29)30-16-31-25/h2-5,7-10,14-16,22H,6,11-12H2,1H3,(H2,29,30,31)/t22-/s2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362684
PNG
(US9840498, 10)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc(C)c1C#N)c1nc2cccc(-c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H27N9O2/c1-17-22(13-30)26(35-29(31)33-17)37-16-20(40-3)12-24(37)27-34-23-11-7-10-21(18-14-32-36(2)15-18)25(23)28(39)38(27)19-8-5-4-6-9-19/h4-11,14-15,20,24H,12,16H2,1-3H3,(H2,31,33,35)/t20-,24-/s2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362677
PNG
(US9840498, 3)
Show SMILES COc1ncc(cn1)-c1cccc2nc([C@@H]3CCCN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H23N9O2/c1-39-28-31-14-17(15-32-28)19-9-5-10-21-23(19)27(38)37(18-7-3-2-4-8-18)26(35-21)22-11-6-12-36(22)25-20(13-29)24(30)33-16-34-25/h2-5,7-10,14-16,22H,6,11-12H2,1H3,(H2,30,33,34)/t22-/s2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362685
PNG
(US9840498, 11)
Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(N)nc2[nH]cnc12)c1nc2cccc(-c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C28H26N10O2/c1-36-13-16(12-32-36)19-9-6-10-20-22(19)27(39)38(17-7-4-3-5-8-17)25(33-20)21-11-18(40-2)14-37(21)26-23-24(31-15-30-23)34-28(29)35-26/h3-10,12-13,15,18,21H,11,14H2,1-2H3,(H3,29,30,31,34,35)/t18-,21-/s2
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n/an/a 2.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM362689
PNG
(US9840498, 15)
Show SMILES Cc1ccccc1-n1c(nc2cccc(-c3cn(C)cn3)c2c1=O)[C@@H]1CCCN1c1ncnc(N)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-7-3-4-10-22(17)37-27(23-11-6-12-36(23)26-19(13-29)25(30)31-15-32-26)34-20-9-5-8-18(24(20)28(37)38)21-14-35(2)16-33-21/h3-5,7-10,14-16,23H,6,11-12H2,1-2H3,(H2,30,31,32)/t23-/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362689
PNG
(US9840498, 15)
Show SMILES Cc1ccccc1-n1c(nc2cccc(-c3cn(C)cn3)c2c1=O)[C@@H]1CCCN1c1ncnc(N)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-7-3-4-10-22(17)37-27(23-11-6-12-36(23)26-19(13-29)25(30)31-15-32-26)34-20-9-5-8-18(24(20)28(37)38)21-14-35(2)16-33-21/h3-5,7-10,14-16,23H,6,11-12H2,1-2H3,(H2,30,31,32)/t23-/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM362689
PNG
(US9840498, 15)
Show SMILES Cc1ccccc1-n1c(nc2cccc(-c3cn(C)cn3)c2c1=O)[C@@H]1CCCN1c1ncnc(N)c1C#N
Show InChI InChI=1/C28H25N9O/c1-17-7-3-4-10-22(17)37-27(23-11-6-12-36(23)26-19(13-29)25(30)31-15-32-26)34-20-9-5-8-18(24(20)28(37)38)21-14-35(2)16-33-21/h3-5,7-10,14-16,23H,6,11-12H2,1-2H3,(H2,30,31,32)/t23-/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...


US Patent US9840498 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%