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Patent code US9840501

Compile Data Set for Download or QSAR

Found 242 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362724
PNG
(N-(4-Chlorophenyl)-6-[(2S)-morpholin-2-yl]pyridin-...)
Show SMILES Clc1ccc(Nc2ccc(nc2)[C@@H]2CNCCO2)cc1
Show InChI InChI=1/C15H16ClN3O/c16-11-1-3-12(4-2-11)19-13-5-6-14(18-9-13)15-10-17-7-8-20-15/h1-6,9,15,17,19H,7-8,10H2/t15-/s2
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1.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362747
PNG
(1-(3-Chlorophenyl)-3-[6-[(2S)-morpholin-2-yl]-3-py...)
Show SMILES Clc1cccc(NC(=O)Nc2ccc(nc2)[C@@H]2CNCCO2)c1
Show InChI InChI=1/C16H17ClN4O2/c17-11-2-1-3-12(8-11)20-16(22)21-13-4-5-14(19-9-13)15-10-18-6-7-23-15/h1-5,8-9,15,18H,6-7,10H2,(H2,20,21,22)/t15-/s2
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1.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362707
PNG
((RS)—N-(4-Chlorophenyl)-6-morpholin-2-yl-pyri...)
Show SMILES Clc1ccc(Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C15H16ClN3O/c16-11-1-3-12(4-2-11)19-13-5-6-14(18-9-13)15-10-17-7-8-20-15/h1-6,9,15,17,19H,7-8,10H2
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1.70n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362708
PNG
((RS)—N-(4-Bromophenyl)-6-morpholin-2-yl-pyrid...)
Show SMILES Brc1ccc(Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C15H16BrN3O/c16-11-1-3-12(4-2-11)19-13-5-6-14(18-9-13)15-10-17-7-8-20-15/h1-6,9,15,17,19H,7-8,10H2
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1.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362726
PNG
(N-(5-Chloro-2-pyridyl)-6-[(2S)-morpholin-2-yl]pyri...)
Show SMILES Clc1ccc(Nc2ccc(nc2)[C@@H]2CNCCO2)nc1
Show InChI InChI=1/C14H15ClN4O/c15-10-1-4-14(18-7-10)19-11-2-3-12(17-8-11)13-9-16-5-6-20-13/h1-4,7-8,13,16H,5-6,9H2,(H,18,19)/t13-/s2
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1.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362727
PNG
(N-(5-Bromo-2-pyridyl)-6-[(2S)-morpholin-2-yl]pyrid...)
Show SMILES Brc1ccc(Nc2ccc(nc2)[C@@H]2CNCCO2)nc1
Show InChI InChI=1/C14H15BrN4O/c15-10-1-4-14(18-7-10)19-11-2-3-12(17-8-11)13-9-16-5-6-20-13/h1-4,7-8,13,16H,5-6,9H2,(H,18,19)/t13-/s2
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2n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362714
PNG
((RS)-1-(3-Chlorophenyl)-3-(6-morpholin-2-yl-3-pyri...)
Show SMILES Clc1cccc(NC(=O)Nc2ccc(nc2)C2CNCCO2)c1
Show InChI InChI=1/C16H17ClN4O2/c17-11-2-1-3-12(8-11)20-16(22)21-13-4-5-14(19-9-13)15-10-18-6-7-23-15/h1-5,8-9,15,18H,6-7,10H2,(H2,20,21,22)
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2.10n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362799
PNG
(2-Isopropyl-N-[6-[(2S)-morpholin-2-yl]-3-pyridyl]-...)
Show SMILES CC(C)n1nc(OCC(F)(F)F)cc1C(=O)Nc1ccc(nc1)[C@@H]1CNCCO1
Show InChI InChI=1/C18H22F3N5O3/c1-11(2)26-14(7-16(25-26)29-10-18(19,20)21)17(27)24-12-3-4-13(23-8-12)15-9-22-5-6-28-15/h3-4,7-8,11,15,22H,5-6,9-10H2,1-2H3,(H,24,27)/t15-/s2
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2.30n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362725
PNG
(6-[(2S)-Morpholin-2-yl]-N-[4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(Nc2ccc(nc2)[C@@H]2CNCCO2)cc1
Show InChI InChI=1/C16H16F3N3O/c17-16(18,19)11-1-3-12(4-2-11)22-13-5-6-14(21-9-13)15-10-20-7-8-23-15/h1-6,9,15,20,22H,7-8,10H2/t15-/s2
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2.70n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362738
PNG
(3-Chloro-N-[6-[(2S)-morpholin-2-yl]-3-pyridyl]benz...)
Show SMILES Clc1cccc(c1)C(=O)Nc1ccc(nc1)[C@@H]1CNCCO1
Show InChI InChI=1/C16H16ClN3O2/c17-12-3-1-2-11(8-12)16(21)20-13-4-5-14(19-9-13)15-10-18-6-7-22-15/h1-5,8-9,15,18H,6-7,10H2,(H,20,21)/t15-/s2
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2.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362716
PNG
((RS)-1-(6-Morpholin-2-yl-3-pyridyl)-3-[4-(trifluor...)
Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C17H17F3N4O2/c18-17(19,20)11-1-3-12(4-2-11)23-16(25)24-13-5-6-14(22-9-13)15-10-21-7-8-26-15/h1-6,9,15,21H,7-8,10H2,(H2,23,24,25)
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2.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362748
PNG
(1-[6-[(2S)-Morpholin-2-yl]-3-pyridyl]-3-[3-(triflu...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(nc2)[C@@H]2CNCCO2)c1
Show InChI InChI=1/C17H17F3N4O2/c18-17(19,20)11-2-1-3-12(8-11)23-16(25)24-13-4-5-14(22-9-13)15-10-21-6-7-26-15/h1-5,8-9,15,21H,6-7,10H2,(H2,23,24,25)/t15-/s2
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3n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362737
PNG
(4-Chloro-N-[6-[(2S)-morpholin-2-yl]-3-pyridyl]benz...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1ccc(nc1)[C@@H]1CNCCO1
Show InChI InChI=1/C16H16ClN3O2/c17-12-3-1-11(2-4-12)16(21)20-13-5-6-14(19-9-13)15-10-18-7-8-22-15/h1-6,9,15,18H,7-8,10H2,(H,20,21)/t15-/s2
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3n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362797
PNG
(3-Butyl-N-[6-[(2S)-morpholin-2-yl]-3-pyridyl]-1H-p...)
Show SMILES CCCCc1cc([nH]n1)C(=O)Nc1ccc(nc1)[C@@H]1CNCCO1
Show InChI InChI=1/C17H23N5O2/c1-2-3-4-12-9-15(22-21-12)17(23)20-13-5-6-14(19-10-13)16-11-18-7-8-24-16/h5-6,9-10,16,18H,2-4,7-8,11H2,1H3,(H,20,23)(H,21,22)/t16-/s2
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3.10n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362725
PNG
(6-[(2S)-Morpholin-2-yl]-N-[4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(Nc2ccc(nc2)[C@@H]2CNCCO2)cc1
Show InChI InChI=1/C16H16F3N3O/c17-16(18,19)11-1-3-12(4-2-11)22-13-5-6-14(21-9-13)15-10-20-7-8-23-15/h1-6,9,15,20,22H,7-8,10H2/t15-/s2
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3.20n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362712
PNG
((RS)-6-Morpholin-2-yl-N-[4-(trifluoromethyl)phenyl...)
Show SMILES FC(F)(F)c1ccc(Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C16H16F3N3O/c17-16(18,19)11-1-3-12(4-2-11)22-13-5-6-14(21-9-13)15-10-20-7-8-23-15/h1-6,9,15,20,22H,7-8,10H2
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3.30n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362736
PNG
(N-[6-[(2S)-Morpholin-2-yl]-3-pyridyl]-6-(trifluoro...)
Show SMILES FC(F)(F)c1cccc(Nc2ccc(nc2)[C@@H]2CNCCO2)n1
Show InChI InChI=1/C15H15F3N4O/c16-15(17,18)13-2-1-3-14(22-13)21-10-4-5-11(20-8-10)12-9-19-6-7-23-12/h1-5,8,12,19H,6-7,9H2,(H,21,22)/t12-/s2
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3.40n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362710
PNG
((RS)—N-(3-Chlorophenyl)-6-morpholin-2-yl-pyri...)
Show SMILES Clc1cccc(Nc2ccc(nc2)C2CNCCO2)c1
Show InChI InChI=1/C15H16ClN3O/c16-11-2-1-3-12(8-11)19-13-4-5-14(18-9-13)15-10-17-6-7-20-15/h1-5,8-9,15,17,19H,6-7,10H2
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3.40n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362735
PNG
(N-[6-[(2S)-Morpholin-2-yl]-3-pyridyl]-5-(trifluoro...)
Show SMILES FC(F)(F)c1ccc(Nc2ccc(nc2)[C@@H]2CNCCO2)nc1
Show InChI InChI=1/C15H15F3N4O/c16-15(17,18)10-1-4-14(21-7-10)22-11-2-3-12(20-8-11)13-9-19-5-6-23-13/h1-4,7-8,13,19H,5-6,9H2,(H,21,22)/t13-/s2
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3.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362767
PNG
(1-(3-Chlorophenyl)-3-[6-[(2R)-morpholin-2-yl]-3-py...)
Show SMILES Clc1cccc(NC(=O)Nc2ccc(nc2)[C@H]2CNCCO2)c1
Show InChI InChI=1/C16H17ClN4O2/c17-11-2-1-3-12(8-11)20-16(22)21-13-4-5-14(19-9-13)15-10-18-6-7-23-15/h1-5,8-9,15,18H,6-7,10H2,(H2,20,21,22)/t15-/s2
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3.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362768
PNG
(1-[6-[(2R)-Morpholin-2-yl]-3-pyridyl]-3-[3-(triflu...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(nc2)[C@H]2CNCCO2)c1
Show InChI InChI=1/C17H17F3N4O2/c18-17(19,20)11-2-1-3-12(8-11)23-16(25)24-13-4-5-14(22-9-13)15-10-21-6-7-26-15/h1-5,8-9,15,21H,6-7,10H2,(H2,23,24,25)/t15-/s2
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3.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362802
PNG
(3-Butyl-4-fluoro-N-[6-[(2R)-morpholin-2-yl]-3-pyri...)
Show SMILES CCCCc1n[nH]c(C(=O)Nc2ccc(nc2)[C@H]2CNCCO2)c1F
Show InChI InChI=1/C17H22FN5O2/c1-2-3-4-13-15(18)16(23-22-13)17(24)21-11-5-6-12(20-9-11)14-10-19-7-8-25-14/h5-6,9,14,19H,2-4,7-8,10H2,1H3,(H,21,24)(H,22,23)/t14-/s2
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3.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362796
PNG
(3-Butyl-4-fluoro-N-[6-[(2S)-morpholin-2-yl]-3-pyri...)
Show SMILES CCCCc1n[nH]c(C(=O)Nc2ccc(nc2)[C@@H]2CNCCO2)c1F
Show InChI InChI=1/C17H22FN5O2/c1-2-3-4-13-15(18)16(23-22-13)17(24)21-11-5-6-12(20-9-11)14-10-19-7-8-25-14/h5-6,9,14,19H,2-4,7-8,10H2,1H3,(H,21,24)(H,22,23)/t14-/s2
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3.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362713
PNG
((RS)-4-Chloro-N-(6-morpholin-2-yl-3-pyridyl)benzam...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1ccc(nc1)C1CNCCO1
Show InChI InChI=1/C16H16ClN3O2/c17-12-3-1-11(2-4-12)16(21)20-13-5-6-14(19-9-13)15-10-18-7-8-22-15/h1-6,9,15,18H,7-8,10H2,(H,20,21)
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3.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362717
PNG
((RS)-1-(4-Chlorophenyl)-3-(6-morpholin-2-yl-3-pyri...)
Show SMILES Clc1ccc(NC(=O)Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C16H17ClN4O2/c17-11-1-3-12(4-2-11)20-16(22)21-13-5-6-14(19-9-13)15-10-18-7-8-23-15/h1-6,9,15,18H,7-8,10H2,(H2,20,21,22)
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3.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362748
PNG
(1-[6-[(2S)-Morpholin-2-yl]-3-pyridyl]-3-[3-(triflu...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(nc2)[C@@H]2CNCCO2)c1
Show InChI InChI=1/C17H17F3N4O2/c18-17(19,20)11-2-1-3-12(8-11)23-16(25)24-13-4-5-14(22-9-13)15-10-21-6-7-26-15/h1-5,8-9,15,21H,6-7,10H2,(H2,23,24,25)/t15-/s2
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3.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362757
PNG
(4-Chloro-N-[6-[(2R)-morpholin-2-yl]-3-pyridyl]benz...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1ccc(nc1)[C@H]1CNCCO1
Show InChI InChI=1/C16H16ClN3O2/c17-12-3-1-11(2-4-12)16(21)20-13-5-6-14(19-9-13)15-10-18-7-8-22-15/h1-6,9,15,18H,7-8,10H2,(H,20,21)/t15-/s2
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3.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362753
PNG
(N-(5-Bromo-2-pyridyl)-6-[(2R)-morpholin-2-yl]pyrid...)
Show SMILES Brc1ccc(Nc2ccc(nc2)[C@H]2CNCCO2)nc1
Show InChI InChI=1/C14H15BrN4O/c15-10-1-4-14(18-7-10)19-11-2-3-12(17-8-11)13-9-16-5-6-20-13/h1-4,7-8,13,16H,5-6,9H2,(H,18,19)/t13-/s2
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3.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362788
PNG
(4-Chloro-3-ethyl-N-[6-[(2R)-morpholin-2-yl]-3-pyri...)
Show SMILES CCc1n[nH]c(C(=O)Nc2ccc(nc2)[C@H]2CNCCO2)c1Cl
Show InChI InChI=1/C15H18ClN5O2/c1-2-10-13(16)14(21-20-10)15(22)19-9-3-4-11(18-7-9)12-8-17-5-6-23-12/h3-4,7,12,17H,2,5-6,8H2,1H3,(H,19,22)(H,20,21)/t12-/s2
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3.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362805
PNG
(2-Isopropyl-N-[6-[(2R)-morpholin-2-yl]-3-pyridyl]-...)
Show SMILES CC(C)n1nc(OCC(F)(F)F)cc1C(=O)Nc1ccc(nc1)[C@H]1CNCCO1
Show InChI InChI=1/C18H22F3N5O3/c1-11(2)26-14(7-16(25-26)29-10-18(19,20)21)17(27)24-12-3-4-13(23-8-12)15-9-22-5-6-28-15/h3-4,7-8,11,15,22H,5-6,9-10H2,1-2H3,(H,24,27)/t15-/s2
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4.10n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362780
PNG
((RS)-4-Chloro-3-ethoxy-N-(6-morpholin-2-yl-3-pyrid...)
Show SMILES CCOc1n[nH]c(C(=O)Nc2ccc(nc2)C2CNCCO2)c1Cl
Show InChI InChI=1/C15H18ClN5O3/c1-2-23-15-12(16)13(20-21-15)14(22)19-9-3-4-10(18-7-9)11-8-17-5-6-24-11/h3-4,7,11,17H,2,5-6,8H2,1H3,(H,19,22)(H,20,21)
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4.10n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362716
PNG
((RS)-1-(6-Morpholin-2-yl-3-pyridyl)-3-[4-(trifluor...)
Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C17H17F3N4O2/c18-17(19,20)11-1-3-12(4-2-11)23-16(25)24-13-5-6-14(22-9-13)15-10-21-7-8-26-15/h1-6,9,15,21H,7-8,10H2,(H2,23,24,25)
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4.20n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362803
PNG
(3-Butyl-N-[6-[(2R)-morpholin-2-yl]-3-pyridyl]-1H-p...)
Show SMILES CCCCc1cc([nH]n1)C(=O)Nc1ccc(nc1)[C@H]1CNCCO1
Show InChI InChI=1/C17H23N5O2/c1-2-3-4-12-9-15(22-21-12)17(23)20-13-5-6-14(19-10-13)16-11-18-7-8-24-16/h5-6,9-10,16,18H,2-4,7-8,11H2,1H3,(H,20,23)(H,21,22)/t16-/s2
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4.30n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362758
PNG
(3-Chloro-N-[6-[(2R)-morpholin-2-yl]-3-pyridyl]benz...)
Show SMILES Clc1cccc(c1)C(=O)Nc1ccc(nc1)[C@H]1CNCCO1
Show InChI InChI=1/C16H16ClN3O2/c17-12-3-1-2-11(8-12)16(21)20-13-4-5-14(19-9-13)15-10-18-6-7-22-15/h1-5,8-9,15,18H,6-7,10H2,(H,20,21)/t15-/s2
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4.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362791
PNG
(4-Fluoro-N-[6-[(2R)-morpholin-2-yl]-3-pyridyl]-3-p...)
Show SMILES CCCc1n[nH]c(C(=O)Nc2ccc(nc2)[C@H]2CNCCO2)c1F
Show InChI InChI=1/C16H20FN5O2/c1-2-3-12-14(17)15(22-21-12)16(23)20-10-4-5-11(19-8-10)13-9-18-6-7-24-13/h4-5,8,13,18H,2-3,6-7,9H2,1H3,(H,20,23)(H,21,22)/t13-/s2
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4.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362717
PNG
((RS)-1-(4-Chlorophenyl)-3-(6-morpholin-2-yl-3-pyri...)
Show SMILES Clc1ccc(NC(=O)Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C16H17ClN4O2/c17-11-1-3-12(4-2-11)20-16(22)21-13-5-6-14(19-9-13)15-10-18-7-8-23-15/h1-6,9,15,18H,7-8,10H2,(H2,20,21,22)
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4.70n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362714
PNG
((RS)-1-(3-Chlorophenyl)-3-(6-morpholin-2-yl-3-pyri...)
Show SMILES Clc1cccc(NC(=O)Nc2ccc(nc2)C2CNCCO2)c1
Show InChI InChI=1/C16H17ClN4O2/c17-11-2-1-3-12(8-11)20-16(22)21-13-4-5-14(19-9-13)15-10-18-6-7-23-15/h1-5,8-9,15,18H,6-7,10H2,(H2,20,21,22)
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4.70n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362731
PNG
(6-[(2R)-Morpholin-2-yl]-N-[4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(Nc2ccc(nc2)[C@H]2CNCCO2)cc1
Show InChI InChI=1/C16H16F3N3O/c17-16(18,19)11-1-3-12(4-2-11)22-13-5-6-14(21-9-13)15-10-20-7-8-23-15/h1-6,9,15,20,22H,7-8,10H2/t15-/s2
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4.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362781
PNG
((RS)-4-Chloro-N-(6-morpholin-2-yl-3-pyridyl)-3-(2,...)
Show SMILES FC(F)(F)COc1n[nH]c(C(=O)Nc2ccc(nc2)C2CNCCO2)c1Cl
Show InChI InChI=1/C15H15ClF3N5O3/c16-11-12(23-24-14(11)27-7-15(17,18)19)13(25)22-8-1-2-9(21-5-8)10-6-20-3-4-26-10/h1-2,5,10,20H,3-4,6-7H2,(H,22,25)(H,23,24)
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4.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362709
PNG
((RS)—N-(4-Ethoxyphenyl)-6-morpholin-2-yl-pyri...)
Show SMILES CCOc1ccc(Nc2ccc(nc2)C2CNCCO2)cc1
Show InChI InChI=1/C17H21N3O2/c1-2-21-15-6-3-13(4-7-15)20-14-5-8-16(19-11-14)17-12-18-9-10-22-17/h3-8,11,17-18,20H,2,9-10,12H2,1H3
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4.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362820
PNG
((RS)-4-Chloro-N-(5-fluoro-6-morpholin-2-yl-3-pyrid...)
Show SMILES CCCc1n[nH]c(C(=O)Nc2cnc(C3CNCCO3)c(F)c2)c1Cl
Show InChI InChI=1/C16H19ClFN5O2/c1-2-3-11-13(17)15(23-22-11)16(24)21-9-6-10(18)14(20-7-9)12-8-19-4-5-25-12/h6-7,12,19H,2-5,8H2,1H3,(H,21,24)(H,22,23)
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4.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM362747
PNG
(1-(3-Chlorophenyl)-3-[6-[(2S)-morpholin-2-yl]-3-py...)
Show SMILES Clc1cccc(NC(=O)Nc2ccc(nc2)[C@@H]2CNCCO2)c1
Show InChI InChI=1/C16H17ClN4O2/c17-11-2-1-3-12(8-11)20-16(22)21-13-4-5-14(19-9-13)15-10-18-6-7-23-15/h1-5,8-9,15,18H,6-7,10H2,(H2,20,21,22)/t15-/s2
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5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362756
PNG
(N-[6-[(2R)-Morpholin-2-yl]-3-pyridyl]-6-(trifluoro...)
Show SMILES FC(F)(F)c1cccc(Nc2ccc(nc2)[C@H]2CNCCO2)n1
Show InChI InChI=1/C15H15F3N4O/c16-15(17,18)13-2-1-3-14(22-13)21-10-4-5-11(20-8-10)12-9-19-6-7-23-12/h1-5,8,12,19H,6-7,9H2,(H,21,22)/t12-/s2
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5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362718
PNG
((RS)-3-Chloro-N-(6-morpholin-2-yl-3-pyridyl)benzam...)
Show SMILES Clc1cccc(c1)C(=O)Nc1ccc(nc1)C1CNCCO1
Show InChI InChI=1/C16H16ClN3O2/c17-12-3-1-2-11(8-12)16(21)20-13-4-5-14(19-9-13)15-10-18-6-7-22-15/h1-5,8-9,15,18H,6-7,10H2,(H,20,21)
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5.10n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362755
PNG
(N-[6-[(2R)-Morpholin-2-yl]-3-pyridyl]-5-(trifluoro...)
Show SMILES FC(F)(F)c1ccc(Nc2ccc(nc2)[C@H]2CNCCO2)nc1
Show InChI InChI=1/C15H15F3N4O/c16-15(17,18)10-1-4-14(21-7-10)22-11-2-3-12(20-8-11)13-9-19-5-6-23-13/h1-4,7-8,13,19H,5-6,9H2,(H,21,22)/t13-/s2
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5.20n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362793
PNG
(4-Bromo-3-cyclopropyl-N-[6-[(2R)-morpholin-2-yl]-3...)
Show SMILES Brc1c(n[nH]c1C(=O)Nc1ccc(nc1)[C@H]1CNCCO1)C1CC1
Show InChI InChI=1/C16H18BrN5O2/c17-13-14(9-1-2-9)21-22-15(13)16(23)20-10-3-4-11(19-7-10)12-8-18-5-6-24-12/h3-4,7,9,12,18H,1-2,5-6,8H2,(H,20,23)(H,21,22)/t12-/s2
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5.30n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362811
PNG
(4-Chloro-N-[6-[(2S)-morpholin-2-yl]-3-pyridyl]-3-(...)
Show SMILES FC(F)(F)COc1n[nH]c(C(=O)Nc2ccc(nc2)[C@@H]2CNCCO2)c1Cl
Show InChI InChI=1/C15H15ClF3N5O3/c16-11-12(23-24-14(11)27-7-15(17,18)19)13(25)22-8-1-2-9(21-5-8)10-6-20-3-4-26-10/h1-2,5,10,20H,3-4,6-7H2,(H,22,25)(H,23,24)/t10-/s2
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5.40n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362721
PNG
((RS)-4-Chloro-N-(6-morpholin-2-yl-3-pyridyl)-3-pro...)
Show SMILES CCCc1n[nH]c(C(=O)Nc2ccc(nc2)C2CNCCO2)c1Cl
Show InChI InChI=1/C16H20ClN5O2/c1-2-3-12-14(17)15(22-21-12)16(23)20-10-4-5-11(19-8-10)13-9-18-6-7-24-13/h4-5,8,13,18H,2-3,6-7,9H2,1H3,(H,20,23)(H,21,22)
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5.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362739
PNG
(N-[6-[(2S)-Morpholin-2-yl]-3-pyridyl]-4-(trifluoro...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(nc1)[C@@H]1CNCCO1
Show InChI InChI=1/C17H16F3N3O2/c18-17(19,20)12-3-1-11(2-4-12)16(24)23-13-5-6-14(22-9-13)15-10-21-7-8-25-15/h1-6,9,15,21H,7-8,10H2,(H,23,24)/t15-/s2
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5.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM362784
PNG
(4-Bromo-3-ethyl-N-[6-[(2S)-morpholin-2-yl]-3-pyrid...)
Show SMILES CCc1n[nH]c(C(=O)Nc2ccc(nc2)[C@@H]2CNCCO2)c1Br
Show InChI InChI=1/C15H18BrN5O2/c1-2-10-13(16)14(21-20-10)15(22)19-9-3-4-11(18-7-9)12-8-17-5-6-23-12/h3-4,7,12,17H,2,5-6,8H2,1H3,(H,19,22)(H,20,21)/t12-/s2
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5.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...


US Patent US9840501 (2017)


Article DOI: 10.1016/j.bmcl.2007.02.049
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%