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Patent code US9840503

Compile Data Set for Download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362831
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-[(t...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCOCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C27H37N5O3/c1-2-3-12-28-27-30-17-24-22-9-4-18(16-29-19-10-13-35-14-11-19)15-23(22)26(34)32(25(24)31-27)20-5-7-21(33)8-6-20/h4,9,15,17,19-21,29,33H,2-3,5-8,10-14,16H2,1H3,(H,28,30,31)/t20-,21-
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362830
PNG
(US9840503, Example 3 | trans-4-[3-(Butylamino)-8-[...)
Show SMILES CCCCNc1ncc-2c(n1)N(Cc1cc(CNC3CCCCC3)ccc-21)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C28H41N5O/c1-2-3-15-29-28-31-18-26-25-14-9-20(17-30-22-7-5-4-6-8-22)16-21(25)19-33(27(26)32-28)23-10-12-24(34)13-11-23/h9,14,16,18,22-24,30,34H,2-8,10-13,15,17,19H2,1H3,(H,29,31,32)/t23-,24-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362838
PNG
(5-(trans-4-aminocyclohexyl)-N-butyl-8-((cyclopenty...)
Show SMILES CCCCNc1ncc2-c3ccc(CNC4CCCC4)cc3CN([C@H]3CC[C@H](N)CC3)c2n1
Show InChI InChI=1/C27H40N6/c1-2-3-14-29-27-31-17-25-24-13-8-19(16-30-22-6-4-5-7-22)15-20(24)18-33(26(25)32-27)23-11-9-21(28)10-12-23/h8,13,15,17,21-23,30H,2-7,9-12,14,16,18,28H2,1H3,(H,29,31,32)/t21-,23-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362837
PNG
(5-(trans-4-Aminocyclohexyl)-N-butyl-8-{[(tetrahydr...)
Show SMILES CCCCNc1ncc2-c3ccc(CNC4CCOCC4)cc3CN([C@H]3CC[C@H](N)CC3)c2n1
Show InChI InChI=1/C27H40N6O/c1-2-3-12-29-27-31-17-25-24-9-4-19(16-30-22-10-13-34-14-11-22)15-20(24)18-33(26(25)32-27)23-7-5-21(28)6-8-23/h4,9,15,17,21-23,30H,2-3,5-8,10-14,16,18,28H2,1H3,(H,29,31,32)/t21-,23-
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Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362836
PNG
(5-(trans-4-Aminocyclohexyl)-N-butyl-8-[(cyclohexyl...)
Show SMILES CCCCNc1ncc-2c(n1)N(Cc1cc(CNC3CCCCC3)ccc-21)[C@H]1CC[C@H](N)CC1
Show InChI InChI=1/C28H42N6/c1-2-3-15-30-28-32-18-26-25-14-9-20(17-31-23-7-5-4-6-8-23)16-21(25)19-34(27(26)33-28)24-12-10-22(29)11-13-24/h9,14,16,18,22-24,31H,2-8,10-13,15,17,19,29H2,1H3,(H,30,32,33)/t22-,24-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362830
PNG
(US9840503, Example 3 | trans-4-[3-(Butylamino)-8-[...)
Show SMILES CCCCNc1ncc-2c(n1)N(Cc1cc(CNC3CCCCC3)ccc-21)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C28H41N5O/c1-2-3-15-29-28-31-18-26-25-14-9-20(17-30-22-7-5-4-6-8-22)16-21(25)19-33(27(26)32-28)23-10-12-24(34)13-11-23/h9,14,16,18,22-24,30,34H,2-8,10-13,15,17,19H2,1H3,(H,29,31,32)/t23-,24-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362829
PNG
(3-(Butylamino)-8-[(cyclohexylamino)methyl]-5-(tran...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCCCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C28H39N5O2/c1-2-3-15-29-28-31-18-25-23-14-9-19(17-30-20-7-5-4-6-8-20)16-24(23)27(35)33(26(25)32-28)21-10-12-22(34)13-11-21/h9,14,16,18,20-22,30,34H,2-8,10-13,15,17H2,1H3,(H,29,31,32)/t21-,22-
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Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362836
PNG
(5-(trans-4-Aminocyclohexyl)-N-butyl-8-[(cyclohexyl...)
Show SMILES CCCCNc1ncc-2c(n1)N(Cc1cc(CNC3CCCCC3)ccc-21)[C@H]1CC[C@H](N)CC1
Show InChI InChI=1/C28H42N6/c1-2-3-15-30-28-32-18-26-25-14-9-20(17-31-23-7-5-4-6-8-23)16-21(25)19-34(27(26)33-28)24-12-10-22(29)11-13-24/h9,14,16,18,22-24,31H,2-8,10-13,15,17,19,29H2,1H3,(H,30,32,33)/t22-,24-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362829
PNG
(3-(Butylamino)-8-[(cyclohexylamino)methyl]-5-(tran...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCCCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C28H39N5O2/c1-2-3-15-29-28-31-18-25-23-14-9-19(17-30-20-7-5-4-6-8-20)16-24(23)27(35)33(26(25)32-28)21-10-12-22(34)13-11-21/h9,14,16,18,20-22,30,34H,2-8,10-13,15,17H2,1H3,(H,29,31,32)/t21-,22-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362829
PNG
(3-(Butylamino)-8-[(cyclohexylamino)methyl]-5-(tran...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCCCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C28H39N5O2/c1-2-3-15-29-28-31-18-25-23-14-9-19(17-30-20-7-5-4-6-8-20)16-24(23)27(35)33(26(25)32-28)21-10-12-22(34)13-11-21/h9,14,16,18,20-22,30,34H,2-8,10-13,15,17H2,1H3,(H,29,31,32)/t21-,22-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362837
PNG
(5-(trans-4-Aminocyclohexyl)-N-butyl-8-{[(tetrahydr...)
Show SMILES CCCCNc1ncc2-c3ccc(CNC4CCOCC4)cc3CN([C@H]3CC[C@H](N)CC3)c2n1
Show InChI InChI=1/C27H40N6O/c1-2-3-12-29-27-31-17-25-24-9-4-19(16-30-22-10-13-34-14-11-22)15-20(24)18-33(26(25)32-27)23-7-5-21(28)6-8-23/h4,9,15,17,21-23,30H,2-3,5-8,10-14,16,18,28H2,1H3,(H,29,31,32)/t21-,23-
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Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362830
PNG
(US9840503, Example 3 | trans-4-[3-(Butylamino)-8-[...)
Show SMILES CCCCNc1ncc-2c(n1)N(Cc1cc(CNC3CCCCC3)ccc-21)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C28H41N5O/c1-2-3-15-29-28-31-18-26-25-14-9-20(17-30-22-7-5-4-6-8-22)16-21(25)19-33(27(26)32-28)23-10-12-24(34)13-11-23/h9,14,16,18,22-24,30,34H,2-8,10-13,15,17,19H2,1H3,(H,29,31,32)/t23-,24-
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Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362836
PNG
(5-(trans-4-Aminocyclohexyl)-N-butyl-8-[(cyclohexyl...)
Show SMILES CCCCNc1ncc-2c(n1)N(Cc1cc(CNC3CCCCC3)ccc-21)[C@H]1CC[C@H](N)CC1
Show InChI InChI=1/C28H42N6/c1-2-3-15-30-28-32-18-26-25-14-9-20(17-31-23-7-5-4-6-8-23)16-21(25)19-34(27(26)33-28)24-12-10-22(29)11-13-24/h9,14,16,18,22-24,31H,2-8,10-13,15,17,19,29H2,1H3,(H,30,32,33)/t22-,24-
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Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362829
PNG
(3-(Butylamino)-8-[(cyclohexylamino)methyl]-5-(tran...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCCCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C28H39N5O2/c1-2-3-15-29-28-31-18-25-23-14-9-19(17-30-20-7-5-4-6-8-20)16-24(23)27(35)33(26(25)32-28)21-10-12-22(34)13-11-21/h9,14,16,18,20-22,30,34H,2-8,10-13,15,17H2,1H3,(H,29,31,32)/t21-,22-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362838
PNG
(5-(trans-4-aminocyclohexyl)-N-butyl-8-((cyclopenty...)
Show SMILES CCCCNc1ncc2-c3ccc(CNC4CCCC4)cc3CN([C@H]3CC[C@H](N)CC3)c2n1
Show InChI InChI=1/C27H40N6/c1-2-3-14-29-27-31-17-25-24-13-8-19(16-30-22-6-4-5-7-22)15-20(24)18-33(26(25)32-27)23-11-9-21(28)10-12-23/h8,13,15,17,21-23,30H,2-7,9-12,14,16,18,28H2,1H3,(H,29,31,32)/t21-,23-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362832
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-{[(...)
Show SMILES CCCCNc1ncc2c3ccc(CNCCO)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C24H33N5O3/c1-2-3-10-26-24-27-15-21-19-9-4-16(14-25-11-12-30)13-20(19)23(32)29(22(21)28-24)17-5-7-18(31)8-6-17/h4,9,13,15,17-18,25,30-31H,2-3,5-8,10-12,14H2,1H3,(H,26,27,28)/t17-,18-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362832
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-{[(...)
Show SMILES CCCCNc1ncc2c3ccc(CNCCO)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C24H33N5O3/c1-2-3-10-26-24-27-15-21-19-9-4-16(14-25-11-12-30)13-20(19)23(32)29(22(21)28-24)17-5-7-18(31)8-6-17/h4,9,13,15,17-18,25,30-31H,2-3,5-8,10-12,14H2,1H3,(H,26,27,28)/t17-,18-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362834
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-(1-...)
Show SMILES CCCCNc1ncc2c3ccc(cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1)-c1cnn(C)c1
Show InChI InChI=1/C25H30N6O2/c1-3-4-11-26-25-27-14-22-20-10-5-16(17-13-28-30(2)15-17)12-21(20)24(33)31(23(22)29-25)18-6-8-19(32)9-7-18/h5,10,12-15,18-19,32H,3-4,6-9,11H2,1-2H3,(H,26,27,29)/t18-,19-
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n/an/a 550n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362831
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-[(t...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCOCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C27H37N5O3/c1-2-3-12-28-27-30-17-24-22-9-4-18(16-29-19-10-13-35-14-11-19)15-23(22)26(34)32(25(24)31-27)20-5-7-21(33)8-6-20/h4,9,15,17,19-21,29,33H,2-3,5-8,10-14,16H2,1H3,(H,28,30,31)/t20-,21-
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n/an/a 550n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362838
PNG
(5-(trans-4-aminocyclohexyl)-N-butyl-8-((cyclopenty...)
Show SMILES CCCCNc1ncc2-c3ccc(CNC4CCCC4)cc3CN([C@H]3CC[C@H](N)CC3)c2n1
Show InChI InChI=1/C27H40N6/c1-2-3-14-29-27-31-17-25-24-13-8-19(16-30-22-6-4-5-7-22)15-20(24)18-33(26(25)32-27)23-11-9-21(28)10-12-23/h8,13,15,17,21-23,30H,2-7,9-12,14,16,18,28H2,1H3,(H,29,31,32)/t21-,23-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362828
PNG
(US9840503, Example 1 | trans-4-[3-(Butylamino)-8-(...)
Show SMILES CCCCNc1ncc2-c3ccc(CN4CCOCC4)cc3CN([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C26H37N5O2/c1-2-3-10-27-26-28-16-24-23-9-4-19(17-30-11-13-33-14-12-30)15-20(23)18-31(25(24)29-26)21-5-7-22(32)8-6-21/h4,9,15-16,21-22,32H,2-3,5-8,10-14,17-18H2,1H3,(H,27,28,29)/t21-,22-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362828
PNG
(US9840503, Example 1 | trans-4-[3-(Butylamino)-8-(...)
Show SMILES CCCCNc1ncc2-c3ccc(CN4CCOCC4)cc3CN([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C26H37N5O2/c1-2-3-10-27-26-28-16-24-23-9-4-19(17-30-11-13-33-14-12-30)15-20(23)18-31(25(24)29-26)21-5-7-22(32)8-6-21/h4,9,15-16,21-22,32H,2-3,5-8,10-14,17-18H2,1H3,(H,27,28,29)/t21-,22-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362829
PNG
(3-(Butylamino)-8-[(cyclohexylamino)methyl]-5-(tran...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCCCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C28H39N5O2/c1-2-3-15-29-28-31-18-25-23-14-9-19(17-30-20-7-5-4-6-8-20)16-24(23)27(35)33(26(25)32-28)21-10-12-22(34)13-11-21/h9,14,16,18,20-22,30,34H,2-8,10-13,15,17H2,1H3,(H,29,31,32)/t21-,22-
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US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362834
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-(1-...)
Show SMILES CCCCNc1ncc2c3ccc(cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1)-c1cnn(C)c1
Show InChI InChI=1/C25H30N6O2/c1-3-4-11-26-25-27-14-22-20-10-5-16(17-13-28-30(2)15-17)12-21(20)24(33)31(23(22)29-25)18-6-8-19(32)9-7-18/h5,10,12-15,18-19,32H,3-4,6-9,11H2,1-2H3,(H,26,27,29)/t18-,19-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362829
PNG
(3-(Butylamino)-8-[(cyclohexylamino)methyl]-5-(tran...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCCCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C28H39N5O2/c1-2-3-15-29-28-31-18-25-23-14-9-19(17-30-20-7-5-4-6-8-20)16-24(23)27(35)33(26(25)32-28)21-10-12-22(34)13-11-21/h9,14,16,18,20-22,30,34H,2-8,10-13,15,17H2,1H3,(H,29,31,32)/t21-,22-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362837
PNG
(5-(trans-4-Aminocyclohexyl)-N-butyl-8-{[(tetrahydr...)
Show SMILES CCCCNc1ncc2-c3ccc(CNC4CCOCC4)cc3CN([C@H]3CC[C@H](N)CC3)c2n1
Show InChI InChI=1/C27H40N6O/c1-2-3-12-29-27-31-17-25-24-9-4-19(16-30-22-10-13-34-14-11-22)15-20(24)18-33(26(25)32-27)23-7-5-21(28)6-8-23/h4,9,15,17,21-23,30H,2-3,5-8,10-14,16,18,28H2,1H3,(H,29,31,32)/t21-,23-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362832
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-{[(...)
Show SMILES CCCCNc1ncc2c3ccc(CNCCO)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C24H33N5O3/c1-2-3-10-26-24-27-15-21-19-9-4-16(14-25-11-12-30)13-20(19)23(32)29(22(21)28-24)17-5-7-18(31)8-6-17/h4,9,13,15,17-18,25,30-31H,2-3,5-8,10-12,14H2,1H3,(H,26,27,28)/t17-,18-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362834
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-(1-...)
Show SMILES CCCCNc1ncc2c3ccc(cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1)-c1cnn(C)c1
Show InChI InChI=1/C25H30N6O2/c1-3-4-11-26-25-27-14-22-20-10-5-16(17-13-28-30(2)15-17)12-21(20)24(33)31(23(22)29-25)18-6-8-19(32)9-7-18/h5,10,12-15,18-19,32H,3-4,6-9,11H2,1-2H3,(H,26,27,29)/t18-,19-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM362835
PNG
(3-(Butylamino)-8-(2, 6-difluorophenyl)-5-(trans-4-...)
Show SMILES CCCCNc1ncc2c3ccc(cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1)-c1c(F)cccc1F
Show InChI InChI=1/C27H28F2N4O2/c1-2-3-13-30-27-31-15-21-19-12-7-16(24-22(28)5-4-6-23(24)29)14-20(19)26(35)33(25(21)32-27)17-8-10-18(34)11-9-17/h4-7,12,14-15,17-18,34H,2-3,8-11,13H2,1H3,(H,30,31,32)/t17-,18-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362831
PNG
(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-[(t...)
Show SMILES CCCCNc1ncc2c3ccc(CNC4CCOCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C27H37N5O3/c1-2-3-12-28-27-30-17-24-22-9-4-18(16-29-19-10-13-35-14-11-19)15-23(22)26(34)32(25(24)31-27)20-5-7-21(33)8-6-20/h4,9,15,17,19-21,29,33H,2-3,5-8,10-14,16H2,1H3,(H,28,30,31)/t20-,21-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM362835
PNG
(3-(Butylamino)-8-(2, 6-difluorophenyl)-5-(trans-4-...)
Show SMILES CCCCNc1ncc2c3ccc(cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1)-c1c(F)cccc1F
Show InChI InChI=1/C27H28F2N4O2/c1-2-3-13-30-27-31-15-21-19-12-7-16(24-22(28)5-4-6-23(24)29)14-20(19)26(35)33(25(21)32-27)17-8-10-18(34)11-9-17/h4-7,12,14-15,17-18,34H,2-3,8-11,13H2,1H3,(H,30,31,32)/t17-,18-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362828
PNG
(US9840503, Example 1 | trans-4-[3-(Butylamino)-8-(...)
Show SMILES CCCCNc1ncc2-c3ccc(CN4CCOCC4)cc3CN([C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C26H37N5O2/c1-2-3-10-27-26-28-16-24-23-9-4-19(17-30-11-13-33-14-12-30)15-20(23)18-31(25(24)29-26)21-5-7-22(32)8-6-21/h4,9,15-16,21-22,32H,2-3,5-8,10-14,17-18H2,1H3,(H,27,28,29)/t21-,22-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM362835
PNG
(3-(Butylamino)-8-(2, 6-difluorophenyl)-5-(trans-4-...)
Show SMILES CCCCNc1ncc2c3ccc(cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1)-c1c(F)cccc1F
Show InChI InChI=1/C27H28F2N4O2/c1-2-3-13-30-27-31-15-21-19-12-7-16(24-22(28)5-4-6-23(24)29)14-20(19)26(35)33(25(21)32-27)17-8-10-18(34)11-9-17/h4-7,12,14-15,17-18,34H,2-3,8-11,13H2,1H3,(H,30,31,32)/t17-,18-
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Incyte Corporation

US Patent


Assay Description
The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...


US Patent US9840503 (2017)


Article DOI: 10.1016/j.bmcl.2006.07.032
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%