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Patent code US9845310

Compile Data Set for Download or QSAR

Found 772 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM360377
PNG
((1R,2S)-1-(5-chloro-2-pyridinyl)-N-(4-(2,4-dimetho...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)ccnc1OC)c1ccc(Cl)cn1
Show InChI InChI=1/C23H24ClN7O5S/c1-14(20(35-3)17-8-7-16(24)13-27-17)37(32,33)30-23-29-28-21(15-6-5-10-25-12-15)31(23)19-18(34-2)9-11-26-22(19)36-4/h5-14,20H,1-4H3,(H,29,30)/t14-,20-/s2
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n/an/an/an/a 0.310n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270146
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,4-dimet...)
Show SMILES COc1ccnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccnc1
Show InChI InChI=1/C22H23ClN8O4S/c1-13(19-26-11-16(23)12-27-19)14(2)36(32,33)30-22-29-28-20(15-6-5-8-24-10-15)31(22)18-17(34-3)7-9-25-21(18)35-4/h5-14H,1-4H3,(H,29,30)/t13-,14-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM363570
PNG
((R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CC(O)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C23H25N7O5S/c1-14-8-16(12-24-9-14)22-27-28-23(30(22)20-18(34-3)6-5-7-19(20)35-4)29-36(32,33)13-17(31)21-25-10-15(2)11-26-21/h5-12,17,31H,13H2,1-4H3,(H,28,29)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270162
PNG
((1R,2S)—N-(4-(4,6-dimethoxypyrimidin-5-yl)-5-...)
Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ncnc1OC)C1CC(C)(C)C1
Show InChI InChI=1/C24H33N7O6S/c1-14(19(35-5)15-11-24(2,3)12-15)38(32,33)30-23-29-28-20(16-9-8-10-17(27-16)34-4)31(23)18-21(36-6)25-13-26-22(18)37-7/h8-10,13-15,19H,11-12H2,1-7H3,(H,29,30)/t14-,19+/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270178
PNG
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2cnc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C27H33N7O5S/c1-16(2)39-25(21-15-29-18(4)13-30-21)19(5)40(35,36)33-27-32-31-26(20-11-17(3)12-28-14-20)34(27)24-22(37-6)9-8-10-23(24)38-7/h8-16,19,25H,1-7H3,(H,32,33)/t19-,25+/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270181
PNG
((1R,2S)-1-(5-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(cn1)C1=CCOCC1
Show InChI InChI=1/C29H33N7O6S/c1-18-13-21(15-30-14-18)28-33-34-29(36(28)25-23(39-3)7-6-8-24(25)40-4)35-43(37,38)19(2)26(41-5)27-31-16-22(17-32-27)20-9-11-42-12-10-20/h6-9,13-17,19,26H,10-12H2,1-5H3,(H,34,35)/t19-,26-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM360421
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM363744
PNG
(US9845310, Example 764.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)C#CC)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C22H25N5O5S/c1-6-8-17(28)15(3)33(29,30)26-22-25-24-21(16-11-14(2)12-23-13-16)27(22)20-18(31-4)9-7-10-19(20)32-5/h7,9-13,15,17,28H,1-5H3,(H,25,26)/t15-,17+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270201
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(C)nn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C24H27N7O5S/c1-14-11-17(13-25-12-14)23-28-29-24(31(23)21-19(35-4)7-6-8-20(21)36-5)30-37(33,34)16(3)22(32)18-10-9-15(2)26-27-18/h6-13,16,22,32H,1-5H3,(H,29,30)/t16-,22+/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270201
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(C)nn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C24H27N7O5S/c1-14-11-17(13-25-12-14)23-28-29-24(31(23)21-19(35-4)7-6-8-20(21)36-5)30-37(33,34)16(3)22(32)18-10-9-15(2)26-27-18/h6-13,16,22,32H,1-5H3,(H,29,30)/t16-,22+/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270206
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(2-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccn1
Show InChI InChI=1/C24H27N7O4S/c1-15-13-27-19(14-26-15)16(2)17(3)36(32,33)30-24-29-28-23(18-9-6-7-12-25-18)31(24)22-20(34-4)10-8-11-21(22)35-5/h6-14,16-17H,1-5H3,(H,29,30)/t16-,17-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270071
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncnn1C
Show InChI InChI=1/C23H28N8O5S/c1-14-10-16(12-24-11-14)21-27-28-23(31(21)19-17(34-4)8-7-9-18(19)35-5)29-37(32,33)15(2)20(36-6)22-25-13-26-30(22)3/h7-13,15,20H,1-6H3,(H,28,29)/t15-,20-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270217
PNG
((2S,3R)-N-(4-(2,6-difluorophenyl)-5-(2-pyridinyl)-...)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccn2)n1-c1c(F)cccc1F)c1ncc(C)cn1
Show InChI InChI=1/C22H21F2N7O2S/c1-13-11-26-20(27-12-13)14(2)15(3)34(32,33)30-22-29-28-21(18-9-4-5-10-25-18)31(22)19-16(23)7-6-8-17(19)24/h4-12,14-15H,1-3H3,(H,29,30)/t14-,15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270225
PNG
((2S,3R)-N-(4-(2,6-difluorophenyl)-5-(3-pyridinyl)-...)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(F)cccc1F)c1ncc(C)cn1
Show InChI InChI=1/C22H21F2N7O2S/c1-13-10-26-20(27-11-13)14(2)15(3)34(32,33)30-22-29-28-21(16-6-5-9-25-12-16)31(22)19-17(23)7-4-8-18(19)24/h4-12,14-15H,1-3H3,(H,29,30)/t14-,15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270231
PNG
((2S,3R)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)n1-c1c(OC)ncnc1OC
Show InChI InChI=1/C23H27N9O5S/c1-13-10-25-17(11-24-13)14(2)15(3)38(33,34)31-23-30-29-20(16-8-7-9-18(28-16)35-4)32(23)19-21(36-5)26-12-27-22(19)37-6/h7-12,14-15H,1-6H3,(H,30,31)/t14-,15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270242
PNG
((2S,3R)-3-(5-chloro-2-pyridinyl)-N-(4-(4-hydroxy-6...)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(O)nc[nH]c1=O)c1ccc(Cl)cn1
Show InChI InChI=1/C20H19ClN8O4S/c1-11(15-6-5-14(21)9-23-15)12(2)34(32,33)28-20-27-26-17(13-4-3-7-22-8-13)29(20)16-18(30)24-10-25-19(16)31/h3-12H,1-2H3,(H,27,28)(H2,24,25,30,31)/t11-,12-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270254
PNG
((3R,5R)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H]2C[C@H](CN(C2)c2ncc(F)cn2)OC(C)C)nnc1-c1cccnc1
Show InChI InChI=1/C27H31FN8O5S/c1-17(2)41-20-11-21(16-35(15-20)26-30-13-19(28)14-31-26)42(37,38)34-27-33-32-25(18-7-6-10-29-12-18)36(27)24-22(39-3)8-5-9-23(24)40-4/h5-10,12-14,17,20-21H,11,15-16H2,1-4H3,(H,33,34)/t20-,21-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270259
PNG
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(pyridin...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2cn3ccccc3n2)nnc1-c1cccnc1
Show InChI InChI=1/C28H31N7O5S/c1-18(2)40-26(21-17-34-15-7-6-13-24(34)30-21)19(3)41(36,37)33-28-32-31-27(20-10-9-14-29-16-20)35(28)25-22(38-4)11-8-12-23(25)39-5/h6-19,26H,1-5H3,(H,32,33)/t19-,26+/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM360493
PNG
((3R)-1-(5-chloro-2-pyrimidinyl)-N-(4-(4,6-dimethox...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(Cl)cn2)n1-c1c(OC)ncnc1OC
Show InChI InChI=1/C23H25ClN10O5S/c1-37-17-8-4-7-16(29-17)19-30-31-23(34(19)18-20(38-2)27-13-28-21(18)39-3)32-40(35,36)15-6-5-9-33(12-15)22-25-10-14(24)11-26-22/h4,7-8,10-11,13,15H,5-6,9,12H2,1-3H3,(H,31,32)/t15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269513
PNG
(N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-pyridinyl...)
Show SMILES CCS(=O)(=O)Nc1nnc(-c2cccc(C)n2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C18H21N5O4S/c1-5-28(24,25)22-18-21-20-17(13-9-6-8-12(2)19-13)23(18)16-14(26-3)10-7-11-15(16)27-4/h6-11H,5H2,1-4H3,(H,21,22)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269515
PNG
((2R)-N-(4-(3,5-dimethyl-4-isoxazolyl)-5-(6-methoxy...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)n1-c1c(C)noc1C
Show InChI InChI=1/C20H21FN8O4S/c1-11(8-16-22-9-14(21)10-23-16)34(30,31)28-20-26-25-19(15-6-5-7-17(24-15)32-4)29(20)18-12(2)27-33-13(18)3/h5-7,9-11H,8H2,1-4H3,(H,26,28)/t11-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269529
PNG
((1R,2S)-N-(4-(4-chlorophenyl)-5-(6-methoxy-2-pyrid...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccc(Cl)cc1)c1ncc(C)cn1
Show InChI InChI=1/C23H24ClN7O4S/c1-14-12-25-21(26-13-14)20(35-4)15(2)36(32,33)30-23-29-28-22(18-6-5-7-19(27-18)34-3)31(23)17-10-8-16(24)9-11-17/h5-13,15,20H,1-4H3,(H,29,30)/t15-,20-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269542
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(OC)cn1
Show InChI InChI=1/C24H27N7O6S/c1-15(21(37-5)22-26-13-17(34-2)14-27-22)38(32,33)30-24-29-28-23(16-8-7-11-25-12-16)31(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,1-5H3,(H,29,30)/t15-,21-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269555
PNG
((1R,2S)-N-(4-(3,4-difluorophenyl)-5-(6-methoxy-2-p...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccc(F)c(F)c1)c1ncc(C)cn1
Show InChI InChI=1/C23H23F2N7O4S/c1-13-11-26-21(27-12-13)20(36-4)14(2)37(33,34)31-23-30-29-22(18-6-5-7-19(28-18)35-3)32(23)15-8-9-16(24)17(25)10-15/h5-12,14,20H,1-4H3,(H,30,31)/t14-,20-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269556
PNG
((1R,2S)-N-(4-(3-acetylphenyl)-5-(6-methoxy-2-pyrid...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cccc(c1)C(C)=O)c1ncc(C)cn1
Show InChI InChI=1/C25H27N7O5S/c1-15-13-26-23(27-14-15)22(37-5)17(3)38(34,35)31-25-30-29-24(20-10-7-11-21(28-20)36-4)32(25)19-9-6-8-18(12-19)16(2)33/h6-14,17,22H,1-5H3,(H,30,31)/t17-,22-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269568
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(F)cn2)nnc1-c1cccnc1
Show InChI InChI=1/C22H22FN7O5S/c1-13(19(31)20-25-11-15(23)12-26-20)36(32,33)29-22-28-27-21(14-6-5-9-24-10-14)30(22)18-16(34-2)7-4-8-17(18)35-3/h4-13,19,31H,1-3H3,(H,28,29)/t13-,19-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269569
PNG
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyr...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)C(=O)N2CCCC2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C23H28N6O6S/c1-15(22(30)28-13-5-6-14-28)36(31,32)27-23-26-25-21(16-9-7-12-19(24-16)35-4)29(23)20-17(33-2)10-8-11-18(20)34-3/h7-12,15H,5-6,13-14H2,1-4H3,(H,26,27)/t15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269591
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methoxy-3-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(OC)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C25H29N7O6S/c1-15-11-27-23(28-12-15)22(38-6)16(2)39(33,34)31-25-30-29-24(17-10-18(35-3)14-26-13-17)32(25)21-19(36-4)8-7-9-20(21)37-5/h7-14,16,22H,1-6H3,(H,30,31)/t16-,22-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269592
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269594
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C25H29N7O5S/c1-6-37-22(23-27-13-16(2)14-28-23)17(3)38(33,34)31-25-30-29-24(18-9-8-12-26-15-18)32(25)21-19(35-4)10-7-11-20(21)36-5/h7-15,17,22H,6H2,1-5H3,(H,30,31)/t17-,22-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269611
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(F)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C23H24FN7O5S/c1-13-8-15(10-25-9-13)22-28-29-23(31(22)19-17(35-3)6-5-7-18(19)36-4)30-37(33,34)14(2)20(32)21-26-11-16(24)12-27-21/h5-12,14,20,32H,1-4H3,(H,29,30)/t14-,20-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269613
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269613
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269616
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C23H24FN7O6S/c1-13(20(32)21-25-11-14(24)12-26-21)38(33,34)30-23-29-28-22(15-7-5-10-18(27-15)37-4)31(23)19-16(35-2)8-6-9-17(19)36-3/h5-13,20,32H,1-4H3,(H,29,30)/t13-,20-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269619
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(2-methoxy-4-pyr...)
Show SMILES COc1cc(ccn1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C23H24FN7O5S/c1-14(10-19-26-12-16(24)13-27-19)37(32,33)30-23-29-28-22(15-8-9-25-20(11-15)36-4)31(23)21-17(34-2)6-5-7-18(21)35-3/h5-9,11-14H,10H2,1-4H3,(H,29,30)/t14-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269632
PNG
((2R)-N-(5-(5-bromo-3-pyridinyl)-4-(2,6-dimethoxyph...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cc(Br)ccn1
Show InChI InChI=1/C22H21BrFN7O4S/c1-13(9-19-26-11-15(24)12-27-19)36(32,33)30-22-29-28-21(16-10-14(23)7-8-25-16)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-8,10-13H,9H2,1-3H3,(H,29,30)/t13-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269642
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethyl-2-pyrid...)
Show SMILES CCc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26FN7O4S/c1-5-17-8-6-9-18(28-17)23-29-30-24(32(23)22-19(35-3)10-7-11-20(22)36-4)31-37(33,34)15(2)12-21-26-13-16(25)14-27-21/h6-11,13-15H,5,12H2,1-4H3,(H,30,31)/t15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269642
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethyl-2-pyrid...)
Show SMILES CCc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26FN7O4S/c1-5-17-8-6-9-18(28-17)23-29-30-24(32(23)22-19(35-3)10-7-11-20(22)36-4)31-37(33,34)15(2)12-21-26-13-16(25)14-27-21/h6-11,13-15H,5,12H2,1-4H3,(H,30,31)/t15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269651
PNG
(6-(4-(2,6-dimethoxyphenyl)-5-((((1R,2S)-2-(5-fluor...)
Show SMILES CNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H27FN8O5S/c1-14(22-28-12-16(26)13-29-22)15(2)40(36,37)33-25-32-31-23(17-8-6-9-18(30-17)24(35)27-3)34(25)21-19(38-4)10-7-11-20(21)39-5/h6-15H,1-5H3,(H,27,35)(H,32,33)/t14-,15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269659
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C24H27N7O5S/c1-15-12-26-22(27-13-15)21(36-5)16(2)37(32,33)30-24-29-28-23(17-8-7-11-25-14-17)31(24)20-18(34-3)9-6-10-19(20)35-4/h6-14,16,21H,1-5H3,(H,29,30)/t16-,21-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM359879
PNG
(N-(5-(5-chloro-3-pyridinyl)-4-(2,6-dimethoxyphenyl...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cc2C#N)nnc1-c1cncc(Cl)c1
Show InChI InChI=1S/C24H20ClFN6O4S/c1-35-20-4-3-5-21(36-2)22(20)32-23(17-10-18(25)14-28-13-17)29-30-24(32)31-37(33,34)9-8-15-6-7-19(26)11-16(15)12-27/h3-7,10-11,13-14H,8-9H2,1-2H3,(H,30,31)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269668
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cccnc1
Show InChI InChI=1/C23H24FN7O4S/c1-14(21-26-12-17(24)13-27-21)15(2)36(32,33)30-23-29-28-22(16-7-6-10-25-11-16)31(23)20-18(34-3)8-5-9-19(20)35-4/h5-15H,1-4H3,(H,29,30)/t14-,15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269680
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(methylami...)
Show SMILES CNc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H30N8O5S/c1-15-13-27-23(28-14-15)22(38-6)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(26-3)29-17)33(25)21-18(36-4)10-8-11-19(21)37-5/h7-14,16,22H,1-6H3,(H,26,29)(H,31,32)/t16-,22-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269686
PNG
(N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCN2[C@@H](C)CCN(C)C2=O)nnc1-c1cncc(C)c1
Show InChI InChI=1/C24H31N7O5S/c1-16-13-18(15-25-14-16)22-26-27-23(31(22)21-19(35-4)7-6-8-20(21)36-5)28-37(33,34)12-11-30-17(2)9-10-29(3)24(30)32/h6-8,13-15,17H,9-12H2,1-5H3,(H,27,28)/t17-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269691
PNG
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridiny...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cccnc1
Show InChI InChI=1/C22H22FN7O4S/c1-14(10-19-25-12-16(23)13-26-19)35(31,32)29-22-28-27-21(15-6-5-9-24-11-15)30(22)20-17(33-2)7-4-8-18(20)34-3/h4-9,11-14H,10H2,1-3H3,(H,28,29)/t14-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269713
PNG
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)
Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269713
PNG
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)
Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269713
PNG
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)
Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269723
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](C)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C25H29N7O4S/c1-15-10-19(14-26-11-15)24-29-30-25(32(24)22-20(35-5)8-7-9-21(22)36-6)31-37(33,34)18(4)17(3)23-27-12-16(2)13-28-23/h7-14,17-18H,1-6H3,(H,30,31)/t17-,18-/s2
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
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