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Patent code US9845313

Compile Data Set for Download or QSAR
Found 167 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258159
PNG
(US9493448, 61 | US9845313, Example 61)
Show SMILES CCc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H24FN5O3S/c1-3-14-11-20(31(28,29)26-21-8-9-23-13-24-21)16(22)12-19(14)30-18-6-4-5-15(18)17-7-10-25-27(17)2/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/s2
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n/an/a 2.60n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM362935
PNG
(5-Chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyr...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)N([Na])c1cscn1
Show InChI InChI=1/C18H17ClFN4O3S2.Na/c1-24-14(5-6-22-24)11-3-2-4-15(11)27-16-8-13(20)17(7-12(16)19)29(25,26)23-18-9-28-10-21-18;/h5-11,15H,2-4H2,1H3;/q-1;+1/t11-,15+;/s2
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n/an/a 10n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258102
PNG
(US9493448, 4 | US9845313, Example 4)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C18H19F2N5O3S2/c1-25-14(6-7-22-25)11-4-2-3-5-15(11)28-16-8-13(20)17(9-12(16)19)30(26,27)24-18-21-10-23-29-18/h6-11,15H,2-5H2,1H3,(H,21,23,24)/t11-,15+/s2
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n/an/a 12n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258107
PNG
(US9493448, 9 | US9845313, Example 9)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C19H21F2N5O3S2/c1-26-15(7-8-23-26)12-5-3-2-4-6-16(12)29-17-9-14(21)18(10-13(17)20)31(27,28)25-19-22-11-24-30-19/h7-12,16H,2-6H2,1H3,(H,22,24,25)/t12-,16+/s2
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n/an/a 14n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258219
PNG
(US9493448, 126 | US9597330, Example 37 | US9845313...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC(F)(F)C[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H22F3N5O3S/c1-13-9-19(33(30,31)28-20-5-7-25-12-26-20)15(22)10-18(13)32-17-3-6-21(23,24)11-14(17)16-4-8-27-29(16)2/h4-5,7-10,12,14,17H,3,6,11H2,1-2H3,(H,25,26,28)/t14-,17+/s2
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n/an/a 14n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258146
PNG
(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/s2
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n/an/a 16n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258164
PNG
(US9493448, 66 | US9845313, Example 66)
Show SMILES Cc1c(O[C@H]2CCCC[C@@H]2c2ccnn2C)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H24FN5O3S/c1-14-17(30-18-6-4-3-5-15(18)16-9-12-25-27(16)2)7-8-19(21(14)22)31(28,29)26-20-10-11-23-13-24-20/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/s2
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258106
PNG
(US9493448, 8 | US9845313, Example 8)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C17H17F2N5O3S2/c1-24-13(5-6-21-24)10-3-2-4-14(10)27-15-7-12(19)16(8-11(15)18)29(25,26)23-17-20-9-22-28-17/h5-10,14H,2-4H2,1H3,(H,20,22,23)/t10-,14+/s2
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258146
PNG
(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/s2
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258244
PNG
(US9493448, 152 | US9597330, Example 52 | US9845313...)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2cn[nH]c2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17ClF3N5O3S/c20-13-5-17(32(29,30)28-18-2-4-24-10-25-18)14(21)6-15(13)31-16-7-19(22,23)3-1-12(16)11-8-26-27-9-11/h2,4-6,8-10,12,16H,1,3,7H2,(H,26,27)(H,24,25,28)/t12-,16+/s2
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258231
PNG
(US9493448, 138 | US9493448, 148 | US9597330, Examp...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c1-12-9-18(29(26,27)25-19-6-7-21-11-22-19)14(20)10-17(12)28-16-4-2-3-13(16)15-5-8-23-24-15/h5-11,13,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t13-,16+/s2
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n/an/a 18n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258146
PNG
(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/s2
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n/an/a 20n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258099
PNG
(US9493448, 1 | US9493448, 2 | US9493448, 3 | US949...)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/s2
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n/an/a 20n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258220
PNG
(US9493448, 127 | US9493448, 143 | US9597330, Examp...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-12-6-18(32(29,30)28-19-3-5-24-11-25-19)15(21)7-16(12)31-17-8-20(22,23)4-2-14(17)13-9-26-27-10-13/h3,5-7,9-11,14,17H,2,4,8H2,1H3,(H,26,27)(H,24,25,28)/t14-,17+/s2
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n/an/a 21n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258233
PNG
(US9493448, 140 | US9493448, 150 | US9597330, Examp...)
Show SMILES Fc1cc(O[C@H]2CCC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C18H17ClFN5O3S/c19-12-8-17(29(26,27)25-18-5-6-21-10-22-18)13(20)9-16(12)28-15-3-1-2-11(15)14-4-7-23-24-14/h4-11,15H,1-3H2,(H,23,24)(H,21,22,25)/t11-,15+/s2
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n/an/a 21n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258122
PNG
(US9493448, 24 | US9845313, Example 24)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1/C19H18F3N5O3S/c1-27-14(5-8-24-27)11-3-2-4-15(11)30-16-9-13(21)17(10-12(16)20)31(28,29)26-18-6-7-23-19(22)25-18/h5-11,15H,2-4H2,1H3,(H,23,25,26)/t11-,15+/s2
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n/an/a 23n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258141
PNG
(US9493448, 43 | US9597330, Example 10 | US9845313,...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H22FN5O3S/c1-13-10-19(30(27,28)25-20-7-8-22-12-23-20)15(21)11-18(13)29-17-5-3-4-14(17)16-6-9-24-26(16)2/h6-12,14,17H,3-5H2,1-2H3,(H,22,23,25)/t14-,17+/s2
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n/an/a 24n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258238
PNG
(US9493448, 146 | US9597330, Example 49 | US9845313...)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17ClF3N5O3S/c1-28-14(2-5-26-28)11-8-19(22,23)9-16(11)31-15-7-13(21)17(6-12(15)20)32(29,30)27-18-3-4-24-10-25-18/h2-7,10-11,16H,8-9H2,1H3,(H,24,25,27)/t11-,16+/s2
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n/an/a 24n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258231
PNG
(US9493448, 138 | US9493448, 148 | US9597330, Examp...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c1-12-9-18(29(26,27)25-19-6-7-21-11-22-19)14(20)10-17(12)28-16-4-2-3-13(16)15-5-8-23-24-15/h5-11,13,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t13-,16+/s2
PDB

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n/an/a 24n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM301817
PNG
(5-Chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyr...)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-28-18(7-10-26-28)15-5-3-2-4-6-19(15)31-14-11-16(22)21(17(23)12-14)32(29,30)27-20-8-9-24-13-25-20/h7-13,15,19H,2-6H2,1H3,(H,24,25,27)/t15-,19+/s2
PDB

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n/an/a 28n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258113
PNG
(US9493448, 15 | US9845313, Example 15)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1nccs1
Show InChI InChI=1/C18H18F2N4O3S2/c1-24-14(5-6-22-24)11-3-2-4-15(11)27-16-9-13(20)17(10-12(16)19)29(25,26)23-18-21-7-8-28-18/h5-11,15H,2-4H2,1H3,(H,21,23)/t11-,15+/s2
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n/an/a 28n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM363077
PNG
(5-Chloro-2-fluoro-4-{[(1S,2R)-2-(1H-pyrazol-5-yl)c...)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1cc[nH]cn1
PDB

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n/an/a 28n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258246
PNG
(US9493448, 155 | US9597330, Example 54 | US9845313...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-12-8-18(32(29,30)28-19-4-6-24-11-25-19)14(21)9-16(12)31-17-10-20(22,23)5-2-13(17)15-3-7-26-27-15/h3-4,6-9,11,13,17H,2,5,10H2,1H3,(H,26,27)(H,24,25,28)/t13-,17+/s2
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n/an/a 28n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258144
PNG
(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-27-17(6-9-25-27)14-4-2-3-5-18(14)30-13-10-15(21)20(16(22)11-13)31(28,29)26-19-7-8-23-12-24-19/h6-12,14,18H,2-5H2,1H3,(H,23,24,26)/t14-,18+/s2
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n/an/a 30n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258205
PNG
(US9493448, 111 | US9845313, Example 111)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1/C19H18F3N5O3S/c1-27-15(5-8-24-27)12-3-2-4-16(12)30-11-9-13(20)18(14(21)10-11)31(28,29)26-17-6-7-23-19(22)25-17/h5-10,12,16H,2-4H2,1H3,(H,23,25,26)/t12-,16+/s2
PDB

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n/an/a 30n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM362934
PNG
(5-Chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyr...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)N([Na])c1cscn1
Show InChI InChI=1/C19H19ClFN4O3S2.Na/c1-25-15(6-7-23-25)12-4-2-3-5-16(12)28-17-9-14(21)18(8-13(17)20)30(26,27)24-19-10-29-11-22-19;/h6-12,16H,2-5H2,1H3;/q-1;+1/t12-,16+;/s2
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n/an/a 30n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258185
PNG
(US9493448, 137 | US9493448, 90 | US9597330, Exampl...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H22F3N5O3S/c1-13-9-19(33(30,31)28-20-5-7-25-12-26-20)15(22)10-17(13)32-18-11-21(23,24)6-3-14(18)16-4-8-27-29(16)2/h4-5,7-10,12,14,18H,3,6,11H2,1-2H3,(H,25,26,28)/t14-,18+/s2
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n/an/a 30n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258157
PNG
(US9493448, 59 | US9597330, Example 18 | US9845313,...)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-2-28-18(7-10-26-28)15-5-3-4-6-19(15)31-14-11-16(22)21(17(23)12-14)32(29,30)27-20-8-9-24-13-25-20/h7-13,15,19H,2-6H2,1H3,(H,24,25,27)/t15-,19+/s2
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n/an/a 31n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258162
PNG
(US9493448, 64 | US9597330, Example 21 | US9845313,...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H24FN5O3S/c1-14-11-20(31(28,29)26-21-8-9-23-13-24-21)16(22)12-19(14)30-18-6-4-3-5-15(18)17-7-10-25-27(17)2/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/s2
PDB

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n/an/a 31n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258191
PNG
(US9493448, 97 | US9845313, Example 97)
Show SMILES Cn1nccc1[C@H]1C[C@H](C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1/C26H25F2N5O4S/c1-33-22(7-10-31-33)19-11-18(36-15-17-5-3-2-4-6-17)12-23(19)37-24-13-21(28)25(14-20(24)27)38(34,35)32-26-8-9-29-16-30-26/h2-10,13-14,16,18-19,23H,11-12,15H2,1H3,(H,29,30,32)/t18-,19-,23+/s2
PDB

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n/an/a 34n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258227
PNG
(US9493448, 134 | US9845313, Example 134)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nncs1
Show InChI InChI=1/C18H17ClF3N5O3S2/c1-27-13(3-5-24-27)10-2-4-18(21,22)8-15(10)30-14-7-12(20)16(6-11(14)19)32(28,29)26-17-25-23-9-31-17/h3,5-7,9-10,15H,2,4,8H2,1H3,(H,25,26)/t10-,15+/s2
PDB

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n/an/a 34n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258233
PNG
(US9493448, 140 | US9493448, 150 | US9597330, Examp...)
Show SMILES Fc1cc(O[C@H]2CCC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C18H17ClFN5O3S/c19-12-8-17(29(26,27)25-18-5-6-21-10-22-18)13(20)9-16(12)28-15-3-1-2-11(15)14-4-7-23-24-14/h4-11,15H,1-3H2,(H,23,24)(H,21,22,25)/t11-,15+/s2
PDB

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n/an/a 34n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258176
PNG
(US9493448, 172 | US9493448, 81 | US9597330, Exampl...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H22FN5O3S/c1-13-8-19(30(27,28)26-20-6-7-22-12-23-20)16(21)9-18(13)29-17-5-3-2-4-15(17)14-10-24-25-11-14/h6-12,15,17H,2-5H2,1H3,(H,24,25)(H,22,23,26)/t15-,17+/s2
PDB

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n/an/a 34n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258232
PNG
(US9493448, 139 | US9597330, Example 45 | US9845313...)
Show SMILES Fc1cc(O[C@H]2CCC[C@@H]2c2ccn[nH]2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C18H17F2N5O3S/c19-13-8-11(28-16-3-1-2-12(16)15-4-7-23-24-15)9-14(20)18(13)29(26,27)25-17-5-6-21-10-22-17/h4-10,12,16H,1-3H2,(H,23,24)(H,21,22,25)/t12-,16+/s2
PDB

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n/an/a 35n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258170
PNG
(US9493448, 72 | US9597330, Example 23 | US9845313,...)
Show SMILES Cn1nccc1[C@H]1CCC(C)(C)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C22H25F2N5O3S/c1-22(2)7-4-14(17-5-9-27-29(17)3)19(12-22)32-18-10-16(24)20(11-15(18)23)33(30,31)28-21-6-8-25-13-26-21/h5-6,8-11,13-14,19H,4,7,12H2,1-3H3,(H,25,26,28)/t14-,19+/s2
PDB

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n/an/a 36n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258145
PNG
(US9493448, 102 | US9493448, 47 | US9597330, Exampl...)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F4N5O3S/c1-29-15(3-7-27-29)12-2-5-20(23,24)10-17(12)32-16-8-14(22)18(9-13(16)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,17H,2,5,10H2,1H3,(H,25,26,28)/t12-,17+/s2
PDB

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n/an/a 36n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258179
PNG
(US9493448, 84 | US9597330, Example 26 | US9845313,...)
Show SMILES Cc1c(O[C@H]2CC(F)(F)CC[C@@H]2c2ccnn2C)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H22F3N5O3S/c1-13-16(3-4-18(20(13)22)33(30,31)28-19-7-9-25-12-26-19)32-17-11-21(23,24)8-5-14(17)15-6-10-27-29(15)2/h3-4,6-7,9-10,12,14,17H,5,8,11H2,1-2H3,(H,25,26,28)/t14-,17+/s2
PDB

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n/an/a 36n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258181
PNG
(US9493448, 86 | US9845313, Example 86)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nncs1
Show InChI InChI=1/C18H19ClFN5O3S2/c1-25-14(6-7-22-25)11-4-2-3-5-15(11)28-16-9-13(20)17(8-12(16)19)30(26,27)24-18-23-21-10-29-18/h6-11,15H,2-5H2,1H3,(H,23,24)/t11-,15+/s2
PDB

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n/an/a 36n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258158
PNG
(US9493448, 60 | US9845313, Example 60)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23ClFN5O3S/c1-28-17(7-10-26-28)14-5-3-2-4-6-18(14)31-19-12-16(23)20(11-15(19)22)32(29,30)27-21-8-9-24-13-25-21/h7-14,18H,2-6H2,1H3,(H,24,25,27)/t14-,18+/s2
PDB

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n/an/a 37n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258152
PNG
(US9493448, 54 | US9597330, Example 16 | US9845313,...)
Show SMILES Cc1cc(ccc1O[C@H]1CCCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H25N5O3S/c1-15-13-16(30(27,28)25-21-10-11-22-14-23-21)7-8-19(15)29-20-6-4-3-5-17(20)18-9-12-24-26(18)2/h7-14,17,20H,3-6H2,1-2H3,(H,22,23,25)/t17-,20+/s2
PDB

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n/an/a 39n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258153
PNG
(US9493448, 55 | US9845313, Example 55)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C22H24N6O3S/c1-28-19(9-12-26-28)18-5-3-2-4-6-21(18)31-20-8-7-17(13-16(20)14-23)32(29,30)27-22-10-11-24-15-25-22/h7-13,15,18,21H,2-6H2,1H3,(H,24,25,27)/t18-,21+/s2
PDB

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n/an/a 39n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258252
PNG
(US9493448, 161 | US9493448, 165 | US9597330, Examp...)
Show SMILES Cn1nccc1[C@H]1C[C@H](O)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/s2
PDB

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n/an/a 40n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258247
PNG
(US9493448, 156 | US9597330, Example 55 | US9845313...)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17ClF3N5O3S/c20-12-7-17(32(29,30)28-18-3-5-24-10-25-18)13(21)8-15(12)31-16-9-19(22,23)4-1-11(16)14-2-6-26-27-14/h2-3,5-8,10-11,16H,1,4,9H2,(H,26,27)(H,24,25,28)/t11-,16+/s2
PDB

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n/an/a 41n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258201
PNG
(US9493448, 107 | US9597330, Example 31 | US9845313...)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17F4N5O3S/c1-28-14(2-5-26-28)11-8-19(22,23)9-16(11)31-15-6-13(21)17(7-12(15)20)32(29,30)27-18-3-4-24-10-25-18/h2-7,10-11,16H,8-9H2,1H3,(H,24,25,27)/t11-,16+/s2
PDB

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n/an/a 42n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258165
PNG
(US9493448, 67 | US9597330, Example 22 | US9845313,...)
Show SMILES Cn1nccc1[C@H]1CC(C)(C)CC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C22H25F2N5O3S/c1-22(2)7-4-18(14(12-22)17-5-9-27-29(17)3)32-19-10-16(24)20(11-15(19)23)33(30,31)28-21-6-8-25-13-26-21/h5-6,8-11,13-14,18H,4,7,12H2,1-3H3,(H,25,26,28)/t14-,18+/s2
PDB

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n/an/a 43n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258125
PNG
(US9493448, 27 | US9597330, Example 4 | US9845313, ...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-16(5-8-24-26)13-3-2-4-17(13)29-12-9-14(20)19(15(21)10-12)30(27,28)25-18-6-7-22-11-23-18/h5-11,13,17H,2-4H2,1H3,(H,22,23,25)/t13-,17+/s2
PDB

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n/an/a 43n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258189
PNG
(US9493448, 171 | US9493448, 94 | US9597330, Exampl...)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c20-15-7-13(29-17-4-2-1-3-14(17)12-9-24-25-10-12)8-16(21)19(15)30(27,28)26-18-5-6-22-11-23-18/h5-11,14,17H,1-4H2,(H,24,25)(H,22,23,26)/t14-,17+/s2
PDB

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n/an/a 43n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258118
PNG
(US9493448, 20 | US9597330, Example 2 | US9845313, ...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19ClFN5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-10-14(21)18(9-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/s2
PDB

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n/an/a 45n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258192
PNG
(US9493448, 98 | US9845313, Example 98)
Show SMILES Cn1nccc1[C@H]1C[C@@H](C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1/C26H25F2N5O4S/c1-33-22(7-10-31-33)19-11-18(36-15-17-5-3-2-4-6-17)12-23(19)37-24-13-21(28)25(14-20(24)27)38(34,35)32-26-8-9-29-16-30-26/h2-10,13-14,16,18-19,23H,11-12,15H2,1H3,(H,29,30,32)/t18-,19+,23-/s2
PDB

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n/an/a 46n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258126
PNG
(US9493448, 28 | US9597330, Example 5 | US9845313, ...)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-2-28-17(7-10-26-28)14-5-3-4-6-18(14)31-19-11-16(23)20(12-15(19)22)32(29,30)27-21-8-9-24-13-25-21/h7-14,18H,2-6H2,1H3,(H,24,25,27)/t14-,18+/s2
PDB

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n/an/a 46n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258148
PNG
(US9493448, 50 | US9597330, Example 14 | US9845313,...)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-2-27-17(6-9-25-27)14-4-3-5-18(14)30-13-10-15(21)20(16(22)11-13)31(28,29)26-19-7-8-23-12-24-19/h6-12,14,18H,2-5H2,1H3,(H,23,24,26)/t14-,18+/s2
PDB

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n/an/a 47n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258203
PNG
(US9493448, 109 | US9597330, Example 32 | US9845313...)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F4N5O3S/c1-29-16(3-7-27-29)13-2-5-20(23,24)10-17(13)32-12-8-14(21)19(15(22)9-12)33(30,31)28-18-4-6-25-11-26-18/h3-4,6-9,11,13,17H,2,5,10H2,1H3,(H,25,26,28)/t13-,17+/s2
PDB

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n/an/a 50n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258248
PNG
(US9493448, 157 | US9597330, Example 56 | US9845313...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC(F)(F)C[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-12-8-18(32(29,30)28-19-4-6-24-11-25-19)14(21)9-17(12)31-16-2-5-20(22,23)10-13(16)15-3-7-26-27-15/h3-4,6-9,11,13,16H,2,5,10H2,1H3,(H,26,27)(H,24,25,28)/t13-,16+/s2
PDB

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n/an/a 50n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258228
PNG
(US9493448, 135 | US9597330, Example 42 | US9845313...)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17F4N5O3S/c1-28-15(2-5-26-28)12-8-19(22,23)9-16(12)31-11-6-13(20)18(14(21)7-11)32(29,30)27-17-3-4-24-10-25-17/h2-7,10,12,16H,8-9H2,1H3,(H,24,25,27)/t12-,16+/s2
PDB

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n/an/a 51n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258177
PNG
(US9493448, 82 | US9845313, Example 82)
Show SMILES Nc1nnccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F2N6O3S/c21-14-10-18(32(29,30)28-19-6-7-24-11-25-19)15(22)9-17(14)31-16-4-2-1-3-12(16)13-5-8-26-27-20(13)23/h5-12,16H,1-4H2,(H2,23,27)(H,24,25,28)/t12-,16+/s2
PDB

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n/an/a 56n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258226
PNG
(US9493448, 133 | US9597330, Example 41 | US9845313...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)C[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-12-7-18(32(29,30)27-19-4-5-24-11-25-19)14(21)8-16(12)31-17-10-20(22,23)9-13(17)15-3-6-26-28(15)2/h3-8,11,13,17H,9-10H2,1-2H3,(H,24,25,27)/t13-,17+/s2
PDB

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n/an/a 57n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258234
PNG
(US9493448, 141 | US9597330, Example 47 | US9845313...)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19ClF3N5O3S/c1-29-15(3-7-27-29)12-2-5-20(23,24)10-17(12)32-16-9-14(22)18(8-13(16)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,17H,2,5,10H2,1H3,(H,25,26,28)/t12-,17+/s2
PDB

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n/an/a 58n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258112
PNG
(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-14(21)18(10-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/s2
PDB

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n/an/a 58n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258224
PNG
(US9493448, 131 | US9597330, Example 40 | US9845313...)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19ClF3N5O3S/c1-29-15(3-7-27-29)12-10-20(23,24)5-2-16(12)32-17-9-14(22)18(8-13(17)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,16H,2,5,10H2,1H3,(H,25,26,28)/t12-,16+/s2
PDB

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n/an/a 59n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258257
PNG
(US9493448, 166 | US9597330, Example 58 | US9845313...)
Show SMILES CC(=O)O[C@@H]1CC[C@H](Oc2cc(F)c(cc2Cl)S(=O)(=O)Nc2ccncn2)[C@H](C1)c1ccnn1C
Show InChI InChI=1/C22H23ClFN5O5S/c1-13(30)33-14-3-4-19(15(9-14)18-5-8-27-29(18)2)34-20-11-17(24)21(10-16(20)23)35(31,32)28-22-6-7-25-12-26-22/h5-8,10-12,14-15,19H,3-4,9H2,1-2H3,(H,25,26,28)/t14-,15-,19+/s2
PDB

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n/an/a 59n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258188
PNG
(US9493448, 93 | US9597330, Example 28 | US9845313,...)
Show SMILES Cn1nccc1[C@H]1CC(C)(C)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-21(2)10-13(16-4-7-26-28(16)3)18(11-21)31-17-8-15(23)19(9-14(17)22)32(29,30)27-20-5-6-24-12-25-20/h4-9,12-13,18H,10-11H2,1-3H3,(H,24,25,27)/t13-,18+/s2
PDB

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n/an/a 65n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258174
PNG
(US9493448, 79 | US9597330, Example 24 | US9845313,...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O3S/c1-27-14(8-11-25-27)13-4-2-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/s2
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n/an/a 70n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258198
PNG
(US9493448, 104 | US9845313, Example 104)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17F4N5O3S/c20-14-5-12(6-15(21)18(14)32(29,30)28-17-2-4-24-10-25-17)31-16-7-19(22,23)3-1-13(16)11-8-26-27-9-11/h2,4-6,8-10,13,16H,1,3,7H2,(H,26,27)(H,24,25,28)/t13-,16+/s2
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n/an/a 71n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258155
PNG
(US9493448, 57 | US9597330, Example 17 | US9845313,...)
Show SMILES Cc1cc(ccc1O[C@H]1CCCCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C22H27N5O3S/c1-16-14-17(31(28,29)26-22-11-12-23-15-24-22)8-9-20(16)30-21-7-5-3-4-6-18(21)19-10-13-25-27(19)2/h8-15,18,21H,3-7H2,1-2H3,(H,23,24,26)/t18-,21+/s2
PDB

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n/an/a 75n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258208
PNG
(US9493448, 114 | US9845313, Example 114)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-15(7-10-23-26)13-3-2-4-16(13)29-12-5-6-17(14(20)11-12)30(27,28)25-18-8-9-22-19(21)24-18/h5-11,13,16H,2-4H2,1H3,(H,22,24,25)/t13-,16+/s2
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n/an/a 78n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258111
PNG
(US9493448, 13 | US9845313, Example 13)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2n2ccnc2)c(Cl)cc1S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C18H18ClFN4O3S2/c19-12-7-17(29(25,26)23-18-9-28-11-22-18)13(20)8-16(12)27-15-4-2-1-3-14(15)24-6-5-21-10-24/h5-11,14-15,23H,1-4H2/t14-,15-/s2
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n/an/a 82n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258150
PNG
(US9493448, 52 | US9597330, Example 15 | US9845313,...)
Show SMILES Cc1cc(ccc1O[C@H]1CCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H23N5O3S/c1-14-12-15(29(26,27)24-20-9-10-21-13-22-20)6-7-18(14)28-19-5-3-4-16(19)17-8-11-23-25(17)2/h6-13,16,19H,3-5H2,1-2H3,(H,21,22,24)/t16-,19+/s2
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n/an/a 83n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258166
PNG
(US9493448, 68 | US9845313, Example 68)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H23FN6O3S/c1-12-8-18(31(28,29)27-19-6-7-23-11-24-19)15(21)9-17(12)30-16-5-3-2-4-13(16)14-10-25-26-20(14)22/h6-11,13,16H,2-5H2,1H3,(H3,22,25,26)(H,23,24,27)/t13-,16+/s2
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n/an/a 86n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258175
PNG
(US9493448, 80 | US9597330, Example 25 | US9845313,...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19ClFN5O3S/c1-26-13(7-10-24-26)12-3-2-4-14(12)29-15-5-6-16(19(21)18(15)20)30(27,28)25-17-8-9-22-11-23-17/h5-12,14H,2-4H2,1H3,(H,22,23,25)/t12-,14+/s2
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n/an/a 86n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258167
PNG
(US9493448, 69 | US9845313, Example 69)
Show SMILES Nc1ncccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H21F2N5O3S/c22-15-11-19(32(29,30)28-20-7-9-25-12-27-20)16(23)10-18(15)31-17-6-2-1-4-13(17)14-5-3-8-26-21(14)24/h3,5,7-13,17H,1-2,4,6H2,(H2,24,26)(H,25,27,28)/t13-,17+/s2
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n/an/a 87n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258185
PNG
(US9493448, 137 | US9493448, 90 | US9597330, Exampl...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H22F3N5O3S/c1-13-9-19(33(30,31)28-20-5-7-25-12-26-20)15(22)10-17(13)32-18-11-21(23,24)6-3-14(18)16-4-8-27-29(16)2/h4-5,7-10,12,14,18H,3,6,11H2,1-2H3,(H,25,26,28)/t14-,18+/s2
PDB

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n/an/a 89n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258140
PNG
(US9493448, 42 | US9845313, Example 42)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-28-17(7-10-26-28)14-5-3-2-4-6-18(14)31-19-11-16(23)20(12-15(19)22)32(29,30)27-21-8-9-24-13-25-21/h7-14,18H,2-6H2,1H3,(H,24,25,27)/t14-,18+/s2
PDB

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n/an/a 91n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258123
PNG
(US9493448, 25 | US9597330, Example 3 | US9845313, ...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-10-15(22)19(11-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/s2
PDB

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n/an/a 95n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258133
PNG
(US9493448, 35 | US9845313, Example 35)
Show SMILES Nc1cc(ccn1)[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H21F2N5O3S/c22-15-11-19(32(29,30)28-21-6-7-25-12-27-21)16(23)10-18(15)31-17-4-2-1-3-14(17)13-5-8-26-20(24)9-13/h5-12,14,17H,1-4H2,(H2,24,26)(H,25,27,28)/t14-,17+/s2
PDB

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n/an/a 99n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258222
PNG
(US9493448, 129 | US9597330, Example 39 | US9845313...)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F4N5O3S/c1-29-16(3-7-27-29)13-10-20(23,24)5-2-17(13)32-12-8-14(21)19(15(22)9-12)33(30,31)28-18-4-6-25-11-26-18/h3-4,6-9,11,13,17H,2,5,10H2,1H3,(H,25,26,28)/t13-,17+/s2
PDB

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n/an/a 100n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258171
PNG
(US9493448, 73 | US9845313, Example 73)
Show SMILES Cc1c(F)c(ccc1O[C@H]1CCCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H23FN6O3S/c1-12-15(30-16-5-3-2-4-13(16)14-10-25-26-20(14)22)6-7-17(19(12)21)31(28,29)27-18-8-9-23-11-24-18/h6-11,13,16H,2-5H2,1H3,(H3,22,25,26)(H,23,24,27)/t13-,16+/s2
PDB

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n/an/a 100n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258136
PNG
(US9493448, 119 | US9493448, 38 | US9493448, 95 | U...)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/s2
PDB

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n/an/a 100n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258160
PNG
(US9493448, 62 | US9845313, Example 62)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19FN6O3S/c1-27-16(5-8-25-27)14-3-2-4-17(14)30-18-10-15(21)19(9-13(18)11-22)31(28,29)26-20-6-7-23-12-24-20/h5-10,12,14,17H,2-4H2,1H3,(H,23,24,26)/t14-,17+/s2
PDB

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n/an/a 120n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258145
PNG
(US9493448, 102 | US9493448, 47 | US9597330, Exampl...)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F4N5O3S/c1-29-15(3-7-27-29)12-2-5-20(23,24)10-17(12)32-16-8-14(22)18(9-13(16)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,17H,2,5,10H2,1H3,(H,25,26,28)/t12-,17+/s2
PDB

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n/an/a 120n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258189
PNG
(US9493448, 171 | US9493448, 94 | US9597330, Exampl...)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c20-15-7-13(29-17-4-2-1-3-14(17)12-9-24-25-10-12)8-16(21)19(15)30(27,28)26-18-5-6-22-11-23-18/h5-11,14,17H,1-4H2,(H,24,25)(H,22,23,26)/t14-,17+/s2
PDB

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n/an/a 120n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258110
PNG
(US9493448, 12 | US9845313, Example 12)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C20H22ClFN4O3S2/c1-2-26-16(7-8-24-26)13-5-3-4-6-17(13)29-18-10-15(22)19(9-14(18)21)31(27,28)25-20-11-30-12-23-20/h7-13,17,25H,2-6H2,1H3/t13-,17+/s2
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n/an/a 120n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258099
PNG
(US9493448, 1 | US9493448, 2 | US9493448, 3 | US949...)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/s2
PDB

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n/an/a 120n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258220
PNG
(US9493448, 127 | US9493448, 143 | US9597330, Examp...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-12-6-18(32(29,30)28-19-3-5-24-11-25-19)15(21)7-16(12)31-17-8-20(22,23)4-2-14(17)13-9-26-27-10-13/h3,5-7,9-11,14,17H,2,4,8H2,1H3,(H,26,27)(H,24,25,28)/t14-,17+/s2
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n/an/a 120n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258252
PNG
(US9493448, 161 | US9493448, 165 | US9597330, Examp...)
Show SMILES Cn1nccc1[C@H]1C[C@H](O)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/s2
PDB

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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258121
PNG
(US9493448, 23 | US9845313, Example 23)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20ClN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-18-6-5-13(11-15(18)20)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/s2
PDB

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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258184
PNG
(US9493448, 89 | US9845313, Example 89)
Show SMILES CCc1cc(ccc1O[C@H]1CCCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H26N6O3S/c1-2-14-11-15(31(28,29)27-20-9-10-23-13-24-20)7-8-18(14)30-19-6-4-3-5-16(19)17-12-25-26-21(17)22/h7-13,16,19H,2-6H2,1H3,(H3,22,25,26)(H,23,24,27)/t16-,19+/s2
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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258163
PNG
(US9493448, 65 | US9845313, Example 65)
Show SMILES Cc1c(O[C@H]2CCC[C@@H]2c2ccnn2C)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H22FN5O3S/c1-13-16(29-17-5-3-4-14(17)15-8-11-24-26(15)2)6-7-18(20(13)21)30(27,28)25-19-9-10-22-12-23-19/h6-12,14,17H,3-5H2,1-2H3,(H,22,23,25)/t14-,17+/s2
PDB

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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258176
PNG
(US9493448, 172 | US9493448, 81 | US9597330, Exampl...)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H22FN5O3S/c1-13-8-19(30(27,28)26-20-6-7-22-12-23-20)16(21)9-18(13)29-17-5-3-2-4-15(17)14-10-24-25-11-14/h6-12,15,17H,2-5H2,1H3,(H,24,25)(H,22,23,26)/t15-,17+/s2
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n/an/a 150n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258169
PNG
(US9493448, 71 | US9845313, Example 71)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20ClFN6O3S/c20-13-7-17(31(28,29)27-18-5-6-23-10-24-18)14(21)8-16(13)30-15-4-2-1-3-11(15)12-9-25-26-19(12)22/h5-11,15H,1-4H2,(H3,22,25,26)(H,23,24,27)/t11-,15+/s2
PDB

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n/an/a 150n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258112
PNG
(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-14(21)18(10-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/s2
PDB

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n/an/a 150n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258139
PNG
(US9493448, 41 | US9845313, Example 41)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-2-28-15(9-12-26-28)14-5-3-4-6-16(14)31-17-7-8-18(21(23)20(17)22)32(29,30)27-19-10-11-24-13-25-19/h7-14,16H,2-6H2,1H3,(H,24,25,27)/t14-,16+/s2
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n/an/a 160n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258116
PNG
(US9493448, 18 | US9845313, Example 18)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1F)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-15(7-10-23-26)13-3-2-4-16(13)29-17-6-5-12(11-14(17)20)30(27,28)25-18-8-9-22-19(21)24-18/h5-11,13,16H,2-4H2,1H3,(H,22,24,25)/t13-,16+/s2
PDB

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n/an/a 170n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258180
PNG
(US9493448, 85 | US9845313, Example 85)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H21FN6O3S/c1-11-7-17(30(27,28)26-18-5-6-22-10-23-18)14(20)8-16(11)29-15-4-2-3-12(15)13-9-24-25-19(13)21/h5-10,12,15H,2-4H2,1H3,(H3,21,24,25)(H,22,23,26)/t12-,15+/s2
PDB

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n/an/a 170n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258186
PNG
(US9493448, 91 | US9845313, Example 91)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20ClFN6O3S/c20-17-14(30-13-4-2-1-3-11(13)12-9-25-26-19(12)22)5-6-15(18(17)21)31(28,29)27-16-7-8-23-10-24-16/h5-11,13H,1-4H2,(H3,22,25,26)(H,23,24,27)/t11-,13+/s2
PDB

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n/an/a 170n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258136
PNG
(US9493448, 119 | US9493448, 38 | US9493448, 95 | U...)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/s2
PDB

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n/an/a 170n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258210
PNG
(US9493448, 116 | US9845313, Example 116)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C18H19F2N5O3S2/c19-13-5-10(6-14(20)17(13)30(26,27)25-16-8-29-9-22-16)28-15-4-2-1-3-11(15)12-7-23-24-18(12)21/h5-9,11,15,25H,1-4H2,(H3,21,23,24)/t11-,15+/s2
PDB

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n/an/a 170n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258195
PNG
(US9493448, 101 | US9845313, Example 101)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c1-12-7-18(29(26,27)25-19-5-6-21-11-22-19)15(20)8-17(12)28-16-4-2-3-14(16)13-9-23-24-10-13/h5-11,14,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t14-,16+/s2
PDB

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n/an/a 180n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258254
PNG
(US9493448, 163 | US9845313, Example 163)
Show SMILES Cn1nccc1[C@H]1CC[C@H](O)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-3-2-12(28)8-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13+,17-/s2
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n/an/a 190n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258143
PNG
(US9493448, 45 | US9845313, Example 45)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H24FN5O3S/c1-2-27-18(9-12-25-27)16-5-3-4-6-19(16)30-15-7-8-20(17(22)13-15)31(28,29)26-21-10-11-23-14-24-21/h7-14,16,19H,2-6H2,1H3,(H,23,24,26)/t16-,19+/s2
PDB

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n/an/a 190n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258225
PNG
(US9493448, 132 | US9845313, Example 132)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17F4N5O3S/c1-28-12(4-7-26-28)11-8-19(22,23)9-14(11)31-13-2-3-15(18(21)17(13)20)32(29,30)27-16-5-6-24-10-25-16/h2-7,10-11,14H,8-9H2,1H3,(H,24,25,27)/t11-,14+/s2
PDB

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n/an/a 200n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258124
PNG
(US9493448, 26 | US9845313, Example 26)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20N6O3S/c1-26-17(7-10-24-26)16-3-2-4-19(16)29-18-6-5-15(11-14(18)12-21)30(27,28)25-20-8-9-22-13-23-20/h5-11,13,16,19H,2-4H2,1H3,(H,22,23,25)/t16-,19+/s2
PDB

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n/an/a 200n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258218
PNG
(US9493448, 125 | US9845313, Example 125)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1nncs1
Show InChI InChI=1/C19H20F3N5O3S2/c1-11-7-17(32(28,29)26-18-25-23-10-31-18)13(20)8-15(11)30-16-9-19(21,22)5-3-12(16)14-4-6-24-27(14)2/h4,6-8,10,12,16H,3,5,9H2,1-2H3,(H,25,26)/t12-,16+/s2
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n/an/a 200n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258135
PNG
(US9493448, 37 | US9845313, Example 37)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-2-27-16(6-9-25-27)13-4-3-5-17(13)30-18-10-15(22)19(11-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/s2
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n/an/a 210n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258199
PNG
(US9493448, 105 | US9845313, Example 105)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F4N5O3S/c1-29-13(5-9-27-29)12-4-7-20(23,24)10-15(12)32-14-2-3-16(19(22)18(14)21)33(30,31)28-17-6-8-25-11-26-17/h2-3,5-6,8-9,11-12,15H,4,7,10H2,1H3,(H,25,26,28)/t12-,15+/s2
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n/an/a 220n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258114
PNG
(US9493448, 16 | US9845313, Example 16)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1F)S(=O)(=O)Nc1nccs1
Show InChI InChI=1/C18H19FN4O3S2/c1-23-15(7-8-21-23)13-3-2-4-16(13)26-17-6-5-12(11-14(17)19)28(24,25)22-18-20-9-10-27-18/h5-11,13,16H,2-4H2,1H3,(H,20,22)/t13-,16+/s2
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n/an/a 230n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258136
PNG
(US9493448, 119 | US9493448, 38 | US9493448, 95 | U...)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/s2
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n/an/a 240n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258154
PNG
(US9493448, 56 | US9845313, Example 56)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H22N6O3S/c1-27-18(8-11-25-27)17-4-2-3-5-20(17)30-19-7-6-16(12-15(19)13-22)31(28,29)26-21-9-10-23-14-24-21/h6-12,14,17,20H,2-5H2,1H3,(H,23,24,26)/t17-,20+/s2
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n/an/a 250n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258190
PNG
(US9493448, 96 | US9845313, Example 96)
Show SMILES CC(=O)Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C22H25FN6O4S/c1-13-9-20(34(31,32)29-21-7-8-24-12-25-21)17(23)10-19(13)33-18-6-4-3-5-15(18)16-11-26-28-22(16)27-14(2)30/h7-12,15,18H,3-6H2,1-2H3,(H,24,25,29)(H2,26,27,28,30)/t15-,18+/s2
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n/an/a 250n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258132
PNG
(US9493448, 34 | US9845313, Example 34)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20F2N6O3S/c20-13-8-17(31(28,29)27-18-5-6-23-10-24-18)14(21)7-16(13)30-15-4-2-1-3-11(15)12-9-25-26-19(12)22/h5-11,15H,1-4H2,(H3,22,25,26)(H,23,24,27)/t11-,15+/s2
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n/an/a 250n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258119
PNG
(US9493448, 21 | US9845313, Example 21)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1C(F)(F)F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-28-16(7-10-26-28)14-3-2-4-17(14)31-18-6-5-13(11-15(18)20(21,22)23)32(29,30)27-19-8-9-24-12-25-19/h5-12,14,17H,2-4H2,1H3,(H,24,25,27)/t14-,17+/s2
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n/an/a 250n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258200
PNG
(US9493448, 106 | US9845313, Example 106)
Show SMILES Cn1nccc1[C@H]1C[C@@H](F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H18F3N5O3S/c1-27-15(2-5-25-27)12-6-11(20)7-16(12)30-17-8-14(22)18(9-13(17)21)31(28,29)26-19-3-4-23-10-24-19/h2-5,8-12,16H,6-7H2,1H3,(H,23,24,26)/t11-,12-,16+/s2
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n/an/a 270n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258214
PNG
(US9493448, 120 | US9845313, Example 120)
Show SMILES CO[C@@H]1C[C@H](Oc2cc(F)c(cc2F)S(=O)(=O)Nc2ccncn2)[C@H](C1)c1ccnn1C
Show InChI InChI=1/C20H21F2N5O4S/c1-27-16(3-6-25-27)13-7-12(30-2)8-17(13)31-18-9-15(22)19(10-14(18)21)32(28,29)26-20-4-5-23-11-24-20/h3-6,9-13,17H,7-8H2,1-2H3,(H,23,24,26)/t12-,13+,17-/s2
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n/an/a 270n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM362927
PNG
(2,5-Difluoro-4-{[(1R*,2R*)-2-phenylcyclohexyl]oxy}...)
Show SMILES Fc1cc(c(F)cc1O[C@@H]1CCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17-/s2
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n/an/a 270n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM363008
PNG
(5-Chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyr...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nncs1
Show InChI InChI=1/C17H17ClFN5O3S2/c1-24-13(5-6-21-24)10-3-2-4-14(10)27-15-8-12(19)16(7-11(15)18)29(25,26)23-17-22-20-9-28-17/h5-10,14H,2-4H2,1H3,(H,22,23)/t10-,14+/s2
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n/an/a 280n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258229
PNG
(US9493448, 136 | US9845313, Example 136)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H18F3N5O3S/c1-27-15(4-7-25-27)13-9-19(21,22)10-16(13)30-12-2-3-17(14(20)8-12)31(28,29)26-18-5-6-23-11-24-18/h2-8,11,13,16H,9-10H2,1H3,(H,23,24,26)/t13-,16+/s2
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n/an/a 290n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM362929
PNG
(2,5-Difluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyrazol-...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)N([Na])c1cscn1
Show InChI InChI=1/C19H19F2N4O3S2.Na/c1-25-15(6-7-23-25)12-4-2-3-5-16(12)28-17-8-14(21)18(9-13(17)20)30(26,27)24-19-10-29-11-22-19;/h6-12,16H,2-5H2,1H3;/q-1;+1/t12-,16+;/s2
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n/an/a 290n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258131
PNG
(US9493448, 33 | US9845313, Example 33)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c20-14-8-18(30(27,28)26-19-5-6-22-11-23-19)15(21)7-17(14)29-16-4-2-1-3-13(16)12-9-24-25-10-12/h5-11,13,16H,1-4H2,(H,24,25)(H,22,23,26)/t13-,16+/s2
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n/an/a 300n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258204
PNG
(US9493448, 110 | US9845313, Example 110)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-28-16(5-9-26-28)14-4-7-20(22,23)11-17(14)31-13-2-3-18(15(21)10-13)32(29,30)27-19-6-8-24-12-25-19/h2-3,5-6,8-10,12,14,17H,4,7,11H2,1H3,(H,24,25,27)/t14-,17+/s2
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n/an/a 300n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258206
PNG
(US9493448, 112 | US9845313, Example 112)
Show SMILES Cn1nccc1[C@H]1C[C@@H](CC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1/C27H27F2N5O4S/c1-34-23(9-12-32-34)20-13-19(37-16-18-5-3-2-4-6-18)7-8-24(20)38-25-14-22(29)26(15-21(25)28)39(35,36)33-27-10-11-30-17-31-27/h2-6,9-12,14-15,17,19-20,24H,7-8,13,16H2,1H3,(H,30,31,33)/t19-,20-,24+/s2
PDB

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n/an/a 310n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258197
PNG
(US9493448, 103 | US9845313, Example 103)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H17F4N5O3S/c20-13-6-17(32(29,30)28-18-2-4-24-10-25-18)14(21)5-15(13)31-16-7-19(22,23)3-1-12(16)11-8-26-27-9-11/h2,4-6,8-10,12,16H,1,3,7H2,(H,26,27)(H,24,25,28)/t12-,16+/s2
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n/an/a 320n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258183
PNG
(US9493448, 88 | US9845313, Example 88)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F4N5O3S/c1-29-15(3-7-27-29)12-10-20(23,24)5-2-16(12)32-17-8-14(22)18(9-13(17)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,16H,2,5,10H2,1H3,(H,25,26,28)/t12-,16+/s2
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n/an/a 320n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258151
PNG
(US9493448, 53 | US9845313, Example 53)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccnnc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F2N5O3S/c21-15-10-19(31(28,29)27-20-6-7-23-12-24-20)16(22)9-18(15)30-17-4-2-1-3-14(17)13-5-8-25-26-11-13/h5-12,14,17H,1-4H2,(H,23,24,27)/t14-,17+/s2
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n/an/a 330n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258142
PNG
(US9493448, 44 | US9845313, Example 44)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H22FN5O3S/c1-26-17(8-11-24-26)15-4-2-3-5-18(15)29-14-6-7-19(16(21)12-14)30(27,28)25-20-9-10-22-13-23-20/h6-13,15,18H,2-5H2,1H3,(H,22,23,25)/t15-,18+/s2
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n/an/a 330n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258168
PNG
(US9493448, 70 | US9845313, Example 70)
Show SMILES Cc1ncccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C22H22F2N4O3S/c1-14-15(6-4-9-26-14)16-5-2-3-7-19(16)31-20-11-18(24)21(12-17(20)23)32(29,30)28-22-8-10-25-13-27-22/h4,6,8-13,16,19H,2-3,5,7H2,1H3,(H,25,27,28)/t16-,19+/s2
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n/an/a 330n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258138
PNG
(US9493448, 40 | US9845313, Example 40)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-27-14(8-11-25-27)13-4-2-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/s2
PDB

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n/an/a 330n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258194
PNG
(US9493448, 100 | US9845313, Example 100)
Show SMILES Cn1nccc1[C@H]1[C@@H](CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1/C27H27F2N5O4S/c1-34-21(10-13-32-34)27-22(37-16-18-6-3-2-4-7-18)8-5-9-23(27)38-24-14-20(29)25(15-19(24)28)39(35,36)33-26-11-12-30-17-31-26/h2-4,6-7,10-15,17,22-23,27H,5,8-9,16H2,1H3,(H,30,31,33)/t22-,23+,27+/s2
PDB

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n/an/a 380n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258193
PNG
(US9493448, 99 | US9845313, Example 99)
Show SMILES Cn1nccc1[C@@H]1[C@H](CCC1(C)C)Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-21(2)7-4-16(20(21)15-5-9-26-28(15)3)31-17-10-14(23)18(11-13(17)22)32(29,30)27-19-6-8-24-12-25-19/h5-6,8-12,16,20H,4,7H2,1-3H3,(H,24,25,27)/t16-,20+/s2
PDB

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n/an/a 410n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258105
PNG
(US9493448, 7 | US9845313, Example 7)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H21F2N3O3S2/c22-16-12-20(31(27,28)26-21-24-13-25-30-21)17(23)11-19(16)29-18-10-6-2-5-9-15(18)14-7-3-1-4-8-14/h1,3-4,7-8,11-13,15,18H,2,5-6,9-10H2,(H,24,25,26)/t15-,18+/s2
PDB

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n/an/a 450n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258128
PNG
(US9493448, 30 | US9845313, Example 30)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-13(7-10-24-26)12-3-2-4-14(12)29-15-5-6-16(19(21)18(15)20)30(27,28)25-17-8-9-22-11-23-17/h5-12,14H,2-4H2,1H3,(H,22,23,25)/t12-,14+/s2
PDB

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n/an/a 500n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258134
PNG
(US9493448, 36 | US9845313, Example 36)
Show SMILES Nc1cc(ccn1)[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F2N5O3S/c21-14-10-18(31(28,29)27-20-5-6-24-11-26-20)15(22)9-17(14)30-16-3-1-2-13(16)12-4-7-25-19(23)8-12/h4-11,13,16H,1-3H2,(H2,23,25)(H,24,26,27)/t13-,16+/s2
PDB

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n/an/a 500n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258115
PNG
(US9493448, 17 | US9845313, Example 17)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1F)S(=O)(=O)Nc1cc(F)ncn1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-15(7-8-24-26)13-3-2-4-16(13)29-17-6-5-12(9-14(17)20)30(27,28)25-19-10-18(21)22-11-23-19/h5-11,13,16H,2-4H2,1H3,(H,22,23,25)/t13-,16+/s2
PDB

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n/an/a 510n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258117
PNG
(US9493448, 19 | US9845313, Example 19)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(Cl)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19ClFN5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-13(20)18(10-14(17)21)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/s2
PDB

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n/an/a 510n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258120
PNG
(US9493448, 22 | US9845313, Example 22)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c20-13-10-18(30(27,28)26-19-6-7-22-11-23-19)14(21)9-17(13)29-16-4-2-1-3-12(16)15-5-8-24-25-15/h5-12,16H,1-4H2,(H,24,25)(H,22,23,26)/t12-,16+/s2
PDB

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n/an/a 520n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258251
PNG
(US9493448, 160 | US9845313, Example 160)
Show SMILES Cn1nccc1[C@H]1CC[C@@H](O)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-3-2-12(28)8-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/s2
PDB

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n/an/a 560n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258209
PNG
(US9493448, 115 | US9845313, Example 115)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H22FN5O3S/c1-2-26-17(8-11-24-26)15-4-3-5-18(15)29-14-6-7-19(16(21)12-14)30(27,28)25-20-9-10-22-13-23-20/h6-13,15,18H,2-5H2,1H3,(H,22,23,25)/t15-,18+/s2
PDB

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n/an/a 580n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258239
PNG
(US9493448, 147 | US9845313, Example 147)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2cn[nH]c2)ccc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H18F3N5O3S/c20-15-7-13(1-2-17(15)31(28,29)27-18-4-6-23-11-24-18)30-16-8-19(21,22)5-3-14(16)12-9-25-26-10-12/h1-2,4,6-7,9-11,14,16H,3,5,8H2,(H,25,26)(H,23,24,27)/t14-,16+/s2
PDB

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n/an/a 600n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258104
PNG
(US9493448, 6 | US9845313, Example 6)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C19H17F2N3O3S2/c20-14-10-18(29(25,26)24-19-22-11-23-28-19)15(21)9-17(14)27-16-8-4-7-13(16)12-5-2-1-3-6-12/h1-3,5-6,9-11,13,16H,4,7-8H2,(H,22,23,24)/t13-,16+/s2
PDB

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n/an/a 610n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258178
PNG
(US9493448, 83 | US9845313, Example 83)
Show SMILES Fc1c(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c20-18-15(29-14-4-2-1-3-13(14)12-9-24-25-10-12)5-6-16(19(18)21)30(27,28)26-17-7-8-22-11-23-17/h5-11,13-14H,1-4H2,(H,24,25)(H,22,23,26)/t13-,14+/s2
PDB

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n/an/a 650n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258156
PNG
(US9493448, 58 | US9845313, Example 58)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H24FN5O3S/c1-27-18(9-12-25-27)16-5-3-2-4-6-19(16)30-15-7-8-20(17(22)13-15)31(28,29)26-21-10-11-23-14-24-21/h7-14,16,19H,2-6H2,1H3,(H,23,24,26)/t16-,19+/s2
PDB

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n/an/a 660n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258123
PNG
(US9493448, 25 | US9597330, Example 3 | US9845313, ...)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-10-15(22)19(11-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/s2
PDB

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n/an/a 660n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258211
PNG
(US9493448, 117 | US9845313, Example 117)
Show SMILES Cn1nccc1[C@@H]1[C@H](CCCC1(F)F)Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H19F4N5O3S/c1-29-14(4-8-27-29)19-15(3-2-6-20(19,23)24)32-16-9-13(22)17(10-12(16)21)33(30,31)28-18-5-7-25-11-26-18/h4-5,7-11,15,19H,2-3,6H2,1H3,(H,25,26,28)/t15-,19+/s2
PDB

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n/an/a 750n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258149
PNG
(US9493448, 51 | US9845313, Example 51)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H23F2N5O3S/c1-28-15(9-12-26-28)14-5-3-2-4-6-16(14)31-17-7-8-18(21(23)20(17)22)32(29,30)27-19-10-11-24-13-25-19/h7-14,16H,2-6H2,1H3,(H,24,25,27)/t14-,16+/s2
PDB

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n/an/a 750n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258253
PNG
(US9493448, 162 | US9845313, Example 162)
Show SMILES Cn1nccc1[C@H]1C[C@@H](O)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13+,17-/s2
PDB

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n/an/a 820n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258223
PNG
(US9493448, 130 | US9845313, Example 130)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-28-16(5-9-26-28)14-11-20(22,23)7-4-17(14)31-13-2-3-18(15(21)10-13)32(29,30)27-19-6-8-24-12-25-19/h2-3,5-6,8-10,12,14,17H,4,7,11H2,1H3,(H,24,25,27)/t14-,17+/s2
PDB

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n/an/a 880n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258215
PNG
(US9493448, 121 | US9845313, Example 121)
Show SMILES CO[C@H]1C[C@H](Oc2cc(F)c(cc2F)S(=O)(=O)Nc2ccncn2)[C@H](C1)c1ccnn1C
Show InChI InChI=1/C20H21F2N5O4S/c1-27-16(3-6-25-27)13-7-12(30-2)8-17(13)31-18-9-15(22)19(10-14(18)21)32(28,29)26-20-4-5-23-11-24-20/h3-6,9-13,17H,7-8H2,1-2H3,(H,23,24,26)/t12-,13-,17+/s2
PDB

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n/an/a 930n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258130
PNG
(US9493448, 32 | US9845313, Example 32)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1n1ccnc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c20-13-10-18(30(27,28)25-19-5-6-22-11-24-19)14(21)9-17(13)29-16-4-2-1-3-15(16)26-8-7-23-12-26/h5-12,15-16H,1-4H2,(H,22,24,25)/t15-,16-/s2
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258187
PNG
(US9493448, 92 | US9845313, Example 92)
Show SMILES Cn1nncc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20F2N6O3S/c1-27-15(10-24-26-27)12-4-2-3-5-16(12)30-17-8-14(21)18(9-13(17)20)31(28,29)25-19-6-7-22-11-23-19/h6-12,16H,2-5H2,1H3,(H,22,23,25)/t12-,16+/s2
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n/an/a 1.00E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258137
PNG
(US9493448, 39 | US9845313, Example 39)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cccnc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C21H20F2N4O3S/c22-16-11-20(31(28,29)27-21-7-9-25-13-26-21)17(23)10-19(16)30-18-6-2-1-5-15(18)14-4-3-8-24-12-14/h3-4,7-13,15,18H,1-2,5-6H2,(H,25,26,27)/t15-,18+/s2
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258207
PNG
(US9493448, 113 | US9845313, Example 113)
Show SMILES Cn1nccc1[C@H]1CC[C@@H](C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1/C27H27F2N5O4S/c1-34-23(9-12-32-34)20-8-7-19(37-16-18-5-3-2-4-6-18)13-24(20)38-25-14-22(29)26(15-21(25)28)39(35,36)33-27-10-11-30-17-31-27/h2-6,9-12,14-15,17,19-20,24H,7-8,13,16H2,1H3,(H,30,31,33)/t19-,20+,24-/s2
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258202
PNG
(US9493448, 108 | US9845313, Example 108)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)ccc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c20-16-9-14(28-17-4-2-1-3-15(17)13-10-23-24-11-13)5-6-18(16)29(26,27)25-19-7-8-21-12-22-19/h5-12,15,17H,1-4H2,(H,23,24)(H,21,22,25)/t15-,17+/s2
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n/an/a 1.70E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258127
PNG
(US9493448, 124 | US9493448, 29 | US9597330, Exampl...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-13-5-6-18(15(20)11-13)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/s2
PDB

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n/an/a 1.80E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258127
PNG
(US9493448, 124 | US9493448, 29 | US9597330, Exampl...)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-13-5-6-18(15(20)11-13)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/s2
PDB

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n/an/a 2.40E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258237
PNG
(US9493448, 144 | US9845313, Example 144)
Show SMILES Cc1cc(c(F)cc1O[C@@H]1CC(F)(F)CC[C@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H20F3N5O3S/c1-12-6-18(32(29,30)28-19-3-5-24-11-25-19)15(21)7-16(12)31-17-8-20(22,23)4-2-14(17)13-9-26-27-10-13/h3,5-7,9-11,14,17H,2,4,8H2,1H3,(H,26,27)(H,24,25,28)/t14-,17+/s2
PDB

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n/an/a 3.40E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258258
PNG
(US9493448, 167 | US9845313, Example 167)
Show SMILES Cn1nccc1[C@@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17-/s2
PDB

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n/an/a 4.60E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258250
PNG
(US9493448, 159 | US9845313, Example 159)
Show SMILES Fc1cc(O[C@@H]2CCCC[C@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19ClFN5O3S/c20-13-9-18(30(27,28)26-19-6-7-22-11-23-19)14(21)10-17(13)29-16-4-2-1-3-12(16)15-5-8-24-25-15/h5-12,16H,1-4H2,(H,24,25)(H,22,23,26)/t12-,16+/s2
PDB

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n/an/a 9.80E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258255
PNG
(US9493448, 164 | US9845313, Example 164)
Show SMILES Cn1nccc1[C@@H]1C[C@@H](O)CC[C@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/s2
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258259
PNG
(US9493448, 168 | US9845313, Example 168)
Show SMILES Cn1nccc1[C@H]1CCCC[C@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17-/s2
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258260
PNG
(US9493448, 169 | US9845313, Example 169)
Show SMILES Fc1cc(O[C@@H]2CCCC[C@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c20-15-7-13(29-17-4-2-1-3-14(17)12-9-24-25-10-12)8-16(21)19(15)30(27,28)26-18-5-6-22-11-23-18/h5-11,14,17H,1-4H2,(H,24,25)(H,22,23,26)/t14-,17+/s2
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258261
PNG
(US9493448, 170 | US9845313, Example 170)
Show SMILES Cc1cc(c(F)cc1O[C@@H]1CCCC[C@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H22FN5O3S/c1-13-8-19(30(27,28)26-20-6-7-22-12-23-20)16(21)9-18(13)29-17-5-3-2-4-15(17)14-10-24-25-11-14/h6-12,15,17H,2-5H2,1H3,(H,24,25)(H,22,23,26)/t15-,17+/s2
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM65040
PNG
(US9493448, 75 | US9845313, Example 75)
Show SMILES Fc1cc(c(F)cc1O[C@@H]1CCCC[C@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/s2
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258212
PNG
(US9493448, 118 | US9845313, Example 118)
Show SMILES CCn1nccc1[C@@H]1CCC[C@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/s2
PDB

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n/an/a 2.10E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258241
PNG
(US9493448, 149 | US9845313, Example 149)
Show SMILES Cc1cc(c(F)cc1O[C@@H]1CCC[C@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c1-12-9-18(29(26,27)25-19-6-7-21-11-22-19)14(20)10-17(12)28-16-4-2-3-13(16)15-5-8-23-24-15/h5-11,13,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t13-,16+/s2
PDB

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n/an/a 3.20E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258243
PNG
(US9493448, 151 | US9845313, Example 151)
Show SMILES Fc1cc(O[C@@H]2CCC[C@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C18H17ClFN5O3S/c19-12-8-17(29(26,27)25-18-5-6-21-10-22-18)13(20)9-16(12)28-15-3-1-2-11(15)14-4-7-23-24-14/h4-11,15H,1-3H2,(H,23,24)(H,21,22,25)/t11-,15+/s2
PDB

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n/an/a 3.30E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258173
PNG
(US9493448, 78 | US9845313, Example 78)
Show SMILES Cn1nccc1[C@@H]1CCC[C@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H19F2N5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-14(21)18(10-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/s2
PDB

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n/an/a 4.30E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258235
PNG
(US9493448, 142 | US9845313, Example 142)
Show SMILES Cn1nccc1[C@@H]1CCCC[C@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258221
PNG
(US9493448, 128 | US9845313, Example 128)
Show SMILES Cn1nccc1[C@@H]1CCC[C@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1/C19H20FN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-13-5-6-18(15(20)11-13)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.20E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM258245
PNG
(US9493448, 153 | US9845313, Example 153)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccnc(=O)[nH]1
Show InChI InChI=1/C20H21ClFN5O4S/c1-27-15(6-9-24-27)12-4-2-3-5-16(12)31-17-11-14(22)18(10-13(17)21)32(29,30)26-19-7-8-23-20(28)25-19/h6-12,16H,2-5H2,1H3,(H2,23,25,26,28)/t12-,16+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...


US Patent US9845313 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%