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Patent code US9845333

Compile Data Set for Download or QSAR
Found 164 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143797
PNG
(US10183953, Example 58 | US8969352, 58 | US9611277...)
Show SMILES Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31)
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2n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143794
PNG
(US10183953, Example 55 | US8969352, 55 | US9611277...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143787
PNG
(US10183953, Example 48 | US8969352, 48 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1
Show InChI InChI=1/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143792
PNG
(US10183953, Example 53 | US8969352, 53 | US9611277...)
Show SMILES FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143756
PNG
(US10183953, Example 17 | US8969352, 17 | US9611277...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3
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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143792
PNG
(US10183953, Example 53 | US8969352, 53 | US9611277...)
Show SMILES FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143794
PNG
(US10183953, Example 55 | US8969352, 55 | US9611277...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143755
PNG
(US10183953, Example 35 | US8969352, 16 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143771
PNG
(US10183953, Example 32 | US8969352, 32 | US9845333...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1
Show InChI InChI=1/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3
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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143771
PNG
(US10183953, Example 32 | US8969352, 32 | US9845333...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1
Show InChI InChI=1/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3
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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143750
PNG
(US10183953, Example 86 | US8969352, 11 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143750
PNG
(US10183953, Example 86 | US8969352, 11 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143797
PNG
(US10183953, Example 58 | US8969352, 58 | US9611277...)
Show SMILES Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143796
PNG
(US10183953, Example 57 | US8969352, 57 | US9611277...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143746
PNG
(US10183953, Example 36 | US8969352, 36 | US8969352...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143793
PNG
(US8969352, 54 | US9611277, Example 54 | US9845333,...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143787
PNG
(US10183953, Example 48 | US8969352, 48 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1
Show InChI InChI=1/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143796
PNG
(US10183953, Example 57 | US8969352, 57 | US9611277...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143793
PNG
(US8969352, 54 | US9611277, Example 54 | US9845333,...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143788
PNG
(US10183953, Example 49 | US8969352, 49 | US9611277...)
Show SMILES Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2
PDB

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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143798
PNG
(US10183953, Example 59 | US8969352, 59 | US9611277...)
Show SMILES FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1
Show InChI InChI=1/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143788
PNG
(US10183953, Example 49 | US8969352, 49 | US9611277...)
Show SMILES Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143789
PNG
(US10183953, Example 50 | US8969352, 50 | US9611277...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1
Show InChI InChI=1/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143755
PNG
(US10183953, Example 35 | US8969352, 16 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143786
PNG
(US10183953, Example 47 | US8969352, 47 | US9611277...)
Show SMILES Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2
Show InChI InChI=1/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143755
PNG
(US10183953, Example 35 | US8969352, 16 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143756
PNG
(US10183953, Example 17 | US8969352, 17 | US9611277...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143750
PNG
(US10183953, Example 86 | US8969352, 11 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143777
PNG
(US10183953, Example 38 | US8969352, 38 | US9611277...)
Show SMILES Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143755
PNG
(US10183953, Example 35 | US8969352, 16 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143753
PNG
(US10183953, Example 43 | US8969352, 14 | US8969352...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143777
PNG
(US10183953, Example 38 | US8969352, 38 | US9611277...)
Show SMILES Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143795
PNG
(US10183953, Example 56 | US8969352, 56 | US9611277...)
Show SMILES CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143798
PNG
(US10183953, Example 59 | US8969352, 59 | US9611277...)
Show SMILES FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1
Show InChI InChI=1/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143789
PNG
(US10183953, Example 50 | US8969352, 50 | US9611277...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1
Show InChI InChI=1/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143758
PNG
(US10183953, Example 19 | US8969352, 19 | US9611277...)
Show SMILES Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143779
PNG
(US10183953, Example 40 | US8969352, 40 | US9611277...)
Show SMILES COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143757
PNG
(US10183953, Example 46 | US8969352, 18 | US8969352...)
Show SMILES Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143795
PNG
(US10183953, Example 56 | US8969352, 56 | US9611277...)
Show SMILES CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30)
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143746
PNG
(US10183953, Example 36 | US8969352, 36 | US8969352...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143750
PNG
(US10183953, Example 86 | US8969352, 11 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143786
PNG
(US10183953, Example 47 | US8969352, 47 | US9611277...)
Show SMILES Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2
Show InChI InChI=1/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2
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11n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143759
PNG
(US10183953, Example 26 | US8969352, 20 | US8969352...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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12n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143746
PNG
(US10183953, Example 36 | US8969352, 36 | US8969352...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2
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12n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143757
PNG
(US10183953, Example 46 | US8969352, 18 | US8969352...)
Show SMILES Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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12n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143747
PNG
(US10183953, Example 8 | US8969352, 8 | US9611277, ...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3
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15n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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15n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143759
PNG
(US10183953, Example 26 | US8969352, 20 | US8969352...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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15n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143759
PNG
(US10183953, Example 26 | US8969352, 20 | US8969352...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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15n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143759
PNG
(US10183953, Example 26 | US8969352, 20 | US8969352...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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15n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143779
PNG
(US10183953, Example 40 | US8969352, 40 | US9611277...)
Show SMILES COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3
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16n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143753
PNG
(US10183953, Example 43 | US8969352, 14 | US8969352...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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16n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143747
PNG
(US10183953, Example 8 | US8969352, 8 | US9611277, ...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143753
PNG
(US10183953, Example 43 | US8969352, 14 | US8969352...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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16n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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16n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143754
PNG
(US10183953, Example 15 | US8969352, 15 | US9611277...)
Show SMILES COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3
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17n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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17n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143778
PNG
(US10183953, Example 39 | US8969352, 39 | US9611277...)
Show SMILES COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H21F3N4O3/c1-32-18-4-2-3-15(16-7-8-28-29-16)21(18)22(31)30-12-13-9-17(30)19(10-13)33-20-6-5-14(11-27-20)23(24,25)26/h2-8,11,13,17,19H,9-10,12H2,1H3,(H,28,29)
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17n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143749
PNG
(US10183953, Example 10 | US8969352, 10 | US9611277...)
Show SMILES CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143758
PNG
(US10183953, Example 19 | US8969352, 19 | US9611277...)
Show SMILES Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143769
PNG
(US10183953, Example 30 | US8969352, 30 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1
Show InChI InChI=1/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143748
PNG
(US10183953, Example 28 | US8969352, 28 | US8969352...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3
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21n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143746
PNG
(US10183953, Example 36 | US8969352, 36 | US8969352...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2
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21n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143753
PNG
(US10183953, Example 43 | US8969352, 14 | US8969352...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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21n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143769
PNG
(US10183953, Example 30 | US8969352, 30 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1
Show InChI InChI=1/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2
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22n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143783
PNG
(US10183953, Example 44 | US8969352, 44 | US9611277...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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22n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143757
PNG
(US10183953, Example 46 | US8969352, 18 | US8969352...)
Show SMILES Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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23n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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23n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143757
PNG
(US10183953, Example 46 | US8969352, 18 | US8969352...)
Show SMILES Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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25n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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25n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143749
PNG
(US10183953, Example 10 | US8969352, 10 | US9611277...)
Show SMILES CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3
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27n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143748
PNG
(US10183953, Example 28 | US8969352, 28 | US8969352...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3
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32n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143754
PNG
(US10183953, Example 15 | US8969352, 15 | US9611277...)
Show SMILES COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3
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40n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143783
PNG
(US10183953, Example 44 | US8969352, 44 | US9611277...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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42n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143751
PNG
(US10183953, Example 12 | US8969352, 12 | US9611277...)
Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3
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44n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143794
PNG
(US10183953, Example 55 | US8969352, 55 | US9611277...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Nc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-7-8-28-31)21(32)30-12-14-9-17(18(30)10-14)29-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3,(H,26,29)
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46n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143768
PNG
(US10183953, Example 29 | US8969352, 29 | US9611277...)
Show SMILES Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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47n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143752
PNG
(US10183953, Example 13 | US8969352, 13 | US9611277...)
Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3
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52n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143784
PNG
(US10183953, Example 45 | US8969352, 45 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br
Show InChI InChI=1/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2
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55n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143768
PNG
(US10183953, Example 29 | US8969352, 29 | US9611277...)
Show SMILES Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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55n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143748
PNG
(US10183953, Example 28 | US8969352, 28 | US8969352...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3
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56n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143751
PNG
(US10183953, Example 12 | US8969352, 12 | US9611277...)
Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3
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59n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143784
PNG
(US10183953, Example 45 | US8969352, 45 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br
Show InChI InChI=1/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2
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60n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143744
PNG
(US10183953, Example 3 | US8969352, 3 | US9611277, ...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3
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63n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143742
PNG
(US10183953, Example 1 | US8969352, 1 | US9611277, ...)
Show SMILES FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1
Show InChI InChI=1/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2
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74n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143772
PNG
(US10183953, Example 33 | US8969352, 33 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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74n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143772
PNG
(US10183953, Example 33 | US8969352, 33 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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86n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143748
PNG
(US10183953, Example 28 | US8969352, 28 | US8969352...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3
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101n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143778
PNG
(US10183953, Example 39 | US8969352, 39 | US9611277...)
Show SMILES COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H21F3N4O3/c1-32-18-4-2-3-15(16-7-8-28-29-16)21(18)22(31)30-12-13-9-17(30)19(10-13)33-20-6-5-14(11-27-20)23(24,25)26/h2-8,11,13,17,19H,9-10,12H2,1H3,(H,28,29)
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108n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143752
PNG
(US10183953, Example 13 | US8969352, 13 | US9611277...)
Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3
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109n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143773
PNG
(US10183953, Example 34 | US8969352, 34 | US9611277...)
Show SMILES Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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117n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143742
PNG
(US10183953, Example 1 | US8969352, 1 | US9611277, ...)
Show SMILES FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1
Show InChI InChI=1/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2
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120n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143744
PNG
(US10183953, Example 3 | US8969352, 3 | US9611277, ...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3
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123n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143778
PNG
(US10183953, Example 39 | US8969352, 39 | US9611277...)
Show SMILES COc1cccc(-c2ccn[nH]2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H21F3N4O3/c1-32-18-4-2-3-15(16-7-8-28-29-16)21(18)22(31)30-12-13-9-17(30)19(10-13)33-20-6-5-14(11-27-20)23(24,25)26/h2-8,11,13,17,19H,9-10,12H2,1H3,(H,28,29)
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132n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143793
PNG
(US8969352, 54 | US9611277, Example 54 | US9845333,...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H20F3N7O/c1-12-2-4-16(31-26-6-7-27-31)19(28-12)20(32)30-11-13-8-15(17(30)9-13)29-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,15,17H,8-9,11H2,1H3,(H,25,29)
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132n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143771
PNG
(US10183953, Example 32 | US8969352, 32 | US9845333...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncco1
Show InChI InChI=1/C23H20F3N3O3/c1-13-3-2-4-16(20(13)21-27-7-8-31-21)22(30)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-28-19)23(24,25)26/h2-8,11,14,17-18H,9-10,12H2,1H3
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143n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143792
PNG
(US10183953, Example 53 | US8969352, 53 | US9611277...)
Show SMILES FC(F)(F)c1ccc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H19F3N6O/c22-21(23,24)14-5-6-19(25-11-14)28-16-9-13-10-18(16)29(12-13)20(31)15-3-1-2-4-17(15)30-26-7-8-27-30/h1-8,11,13,16,18H,9-10,12H2,(H,25,28)
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165n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143776
PNG
(US10183953, Example 37 | US8969352, 37 | US9611277...)
Show SMILES CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3
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170n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143781
PNG
(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Show InChI InChI=1/C21H18F3N3O2/c22-21(23,24)14-4-5-18(26-10-14)29-17-9-12-8-16(17)27(11-12)20(28)15-3-1-2-13-6-7-25-19(13)15/h1-7,10,12,16-17,25H,8-9,11H2
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175n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143797
PNG
(US10183953, Example 58 | US8969352, 58 | US9611277...)
Show SMILES Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H19F4N5O/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(33)32-12-13-8-18(19(32)9-13)31-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2,(H,30,31)
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181n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143781
PNG
(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Show InChI InChI=1/C21H18F3N3O2/c22-21(23,24)14-4-5-18(26-10-14)29-17-9-12-8-16(17)27(11-12)20(28)15-3-1-2-13-6-7-25-19(13)15/h1-7,10,12,16-17,25H,8-9,11H2
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184n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143795
PNG
(US10183953, Example 56 | US8969352, 56 | US9611277...)
Show SMILES CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H23F3N4O2/c1-2-33-19-7-5-15-4-3-9-28-22(15)21(19)23(32)31-13-14-10-17(18(31)11-14)30-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17-18H,2,10-11,13H2,1H3,(H,29,30)
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192n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143743
PNG
(US10183953, Example 2 | US8969352, 2 | US9611277, ...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3
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200n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143798
PNG
(US10183953, Example 59 | US8969352, 59 | US9611277...)
Show SMILES FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1
Show InChI InChI=1/C20H18F3N7O/c21-20(22,23)17-9-25-18(10-24-17)28-14-7-12-8-16(14)29(11-12)19(31)13-3-1-2-4-15(13)30-26-5-6-27-30/h1-6,9-10,12,14,16H,7-8,11H2,(H,25,28)
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213n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143754
PNG
(US10183953, Example 15 | US8969352, 15 | US9611277...)
Show SMILES COc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C22H20F3N5O3/c1-32-17-4-2-3-15(30-27-7-8-28-30)20(17)21(31)29-12-13-9-16(29)18(10-13)33-19-6-5-14(11-26-19)22(23,24)25/h2-8,11,13,16,18H,9-10,12H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143756
PNG
(US10183953, Example 17 | US8969352, 17 | US9611277...)
Show SMILES Cc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C22H20F3N5O2/c1-13-3-2-4-16(20(13)30-27-7-8-28-30)21(31)29-12-14-9-17(29)18(10-14)32-19-6-5-15(11-26-19)22(23,24)25/h2-8,11,14,17-18H,9-10,12H2,1H3
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234n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143796
PNG
(US10183953, Example 57 | US8969352, 57 | US9611277...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Nc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H18F4N6O/c22-14-2-3-17(31-27-5-6-28-31)15(9-14)20(32)30-11-12-7-16(18(30)8-12)29-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,16,18H,7-8,11H2,(H,26,29)
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252n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143776
PNG
(US10183953, Example 37 | US8969352, 37 | US9611277...)
Show SMILES CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3
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265n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143790
PNG
(US10183953, Example 51 | US8969352, 51 | US9611277...)
Show SMILES FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143746
PNG
(US10183953, Example 36 | US8969352, 36 | US8969352...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2
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322n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143779
PNG
(US10183953, Example 40 | US8969352, 40 | US9611277...)
Show SMILES COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H21F3N4O3/c1-33-18-5-2-4-16(22-28-8-3-9-29-22)21(18)23(32)31-13-14-10-17(31)19(11-14)34-20-7-6-15(12-30-20)24(25,26)27/h2-9,12,14,17,19H,10-11,13H2,1H3
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340n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143743
PNG
(US10183953, Example 2 | US8969352, 2 | US9611277, ...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3
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342n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM143773
PNG
(US10183953, Example 34 | US8969352, 34 | US9611277...)
Show SMILES Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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466n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143786
PNG
(US10183953, Example 47 | US8969352, 47 | US9611277...)
Show SMILES Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2
Show InChI InChI=1/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)20-15(3-1-4-16(20)24)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2
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503n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143788
PNG
(US10183953, Example 49 | US8969352, 49 | US9611277...)
Show SMILES Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C20H18BrN5O2/c21-14-5-6-19(22-11-14)28-18-10-13-9-17(18)25(12-13)20(27)15-3-1-2-4-16(15)26-23-7-8-24-26/h1-8,11,13,17-18H,9-10,12H2
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507n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143749
PNG
(US10183953, Example 10 | US8969352, 10 | US9611277...)
Show SMILES CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H22F3N3O3/c1-2-32-18-7-5-15-4-3-9-28-22(15)21(18)23(31)30-13-14-10-17(30)19(11-14)33-20-8-6-16(12-29-20)24(25,26)27/h3-9,12,14,17,19H,2,10-11,13H2,1H3
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526n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143755
PNG
(US10183953, Example 35 | US8969352, 16 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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542n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143791
PNG
(US10183953, Example 52 | US8969352, 52 | US9611277...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3
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550n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143753
PNG
(US10183953, Example 43 | US8969352, 14 | US8969352...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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557n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143757
PNG
(US10183953, Example 46 | US8969352, 18 | US8969352...)
Show SMILES Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143789
PNG
(US10183953, Example 50 | US8969352, 50 | US9611277...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(Br)cn3)C1C2)-n1nccn1
Show InChI InChI=1/C20H19BrN6O2/c1-12-2-4-15(27-23-6-7-24-27)19(25-12)20(28)26-11-13-8-16(26)17(9-13)29-18-5-3-14(21)10-22-18/h2-7,10,13,16-17H,8-9,11H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143790
PNG
(US10183953, Example 51 | US8969352, 51 | US9611277...)
Show SMILES FC(F)(F)c1cccnc1OC1CC2CC1N(C2)C(=O)c1ccccc1-n1nccn1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)15-5-3-7-25-19(15)31-18-11-13-10-17(18)28(12-13)20(30)14-4-1-2-6-16(14)29-26-8-9-27-29/h1-9,13,17-18H,10-12H2
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143777
PNG
(US10183953, Example 38 | US8969352, 38 | US9611277...)
Show SMILES Fc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(21-28-7-2-8-29-21)20(16)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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692n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143770
PNG
(US10183953, Example 31 | US8969352, 31 | US9611277...)
Show SMILES COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3
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707n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143750
PNG
(US10183953, Example 86 | US8969352, 11 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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767n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143746
PNG
(US10183953, Example 36 | US8969352, 36 | US8969352...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-11-14)31-18-10-13-9-17(18)28(12-13)20(30)15-3-1-2-4-16(15)29-26-7-8-27-29/h1-8,11,13,17-18H,9-10,12H2
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800n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143745
PNG
(US10183953, Example 4 | US8969352, 4 | US9611277, ...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3
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837n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143753
PNG
(US10183953, Example 43 | US8969352, 14 | US8969352...)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-16(30-27-5-6-28-30)15(9-14)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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855n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143758
PNG
(US10183953, Example 19 | US8969352, 19 | US9611277...)
Show SMILES Fc1ccc(-c2ncccn2)c(c1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(21-28-6-1-7-29-21)17(10-15)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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945n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143787
PNG
(US10183953, Example 48 | US8969352, 48 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1
Show InChI InChI=1/C22H18BrFN4O2/c23-14-5-6-19(27-11-14)30-18-10-13-9-17(18)28(12-13)22(29)15-3-1-4-16(24)20(15)21-25-7-2-8-26-21/h1-8,11,13,17-18H,9-10,12H2
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972n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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1.00E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143755
PNG
(US10183953, Example 35 | US8969352, 16 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-27-6-7-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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1.00E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143773
PNG
(US10183953, Example 34 | US8969352, 34 | US9611277...)
Show SMILES Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1ccnn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(19(27-12)30-7-6-26-28-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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1.10E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143747
PNG
(US10183953, Example 8 | US8969352, 8 | US9611277, ...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H22F3N3O3/c1-2-32-22-21(17-6-4-3-5-15(17)11-29-22)23(31)30-13-14-9-18(30)19(10-14)33-20-8-7-16(12-28-20)24(25,26)27/h3-8,11-12,14,18-19H,2,9-10,13H2,1H3
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1.45E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143750
PNG
(US10183953, Example 86 | US8969352, 11 | US8969352...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-16-4-1-3-15(20(16)21-28-7-2-8-29-21)22(32)31-12-13-9-17(31)18(10-13)33-19-6-5-14(11-30-19)23(25,26)27/h1-8,11,13,17-18H,9-10,12H2
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1.48E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143784
PNG
(US10183953, Example 45 | US8969352, 45 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1Br
Show InChI InChI=1/C19H15BrF4N2O2/c20-17-12(2-1-3-13(17)21)18(27)26-9-10-6-14(26)15(7-10)28-16-5-4-11(8-25-16)19(22,23)24/h1-5,8,10,14-15H,6-7,9H2
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1.50E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143748
PNG
(US10183953, Example 28 | US8969352, 28 | US8969352...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3
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1.60E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143769
PNG
(US10183953, Example 30 | US8969352, 30 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ncccc2-n2nccn2)nc1
Show InChI InChI=1/C20H17F3N6O2/c21-20(22,23)13-3-4-17(25-10-13)31-16-9-12-8-15(16)28(11-12)19(30)18-14(2-1-5-24-18)29-26-6-7-27-29/h1-7,10,12,15-16H,8-9,11H2
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1.70E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143776
PNG
(US10183953, Example 37 | US8969352, 37 | US9611277...)
Show SMILES CCOc1ccc(C)nc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C21H22F3N3O3/c1-3-29-16-6-4-12(2)26-19(16)20(28)27-11-13-8-15(27)17(9-13)30-18-7-5-14(10-25-18)21(22,23)24/h4-7,10,13,15,17H,3,8-9,11H2,1-2H3
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1.80E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143757
PNG
(US10183953, Example 46 | US8969352, 18 | US8969352...)
Show SMILES Fc1cccc(c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-1-3-15(30-27-6-7-28-30)19(14)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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1.80E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143759
PNG
(US10183953, Example 26 | US8969352, 20 | US8969352...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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2.10E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143783
PNG
(US10183953, Example 44 | US8969352, 44 | US9611277...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H17F4N5O2/c22-14-2-3-15(16(9-14)30-27-5-6-28-30)20(31)29-11-12-7-17(29)18(8-12)32-19-4-1-13(10-26-19)21(23,24)25/h1-6,9-10,12,17-18H,7-8,11H2
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2.20E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143748
PNG
(US10183953, Example 28 | US8969352, 28 | US8969352...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-6-16(30-27-4-5-28-30)19(26-9-12)20(31)29-11-13-7-15(29)17(8-13)32-18-3-2-14(10-25-18)21(22,23)24/h2-6,9-10,13,15,17H,7-8,11H2,1H3
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2.55E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143759
PNG
(US10183953, Example 26 | US8969352, 20 | US8969352...)
Show SMILES Fc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C23H18F4N4O2/c24-15-3-4-16(17(10-15)21-28-6-1-7-29-21)22(32)31-12-13-8-18(31)19(9-13)33-20-5-2-14(11-30-20)23(25,26)27/h1-7,10-11,13,18-19H,8-9,12H2
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2.70E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143772
PNG
(US10183953, Example 33 | US8969352, 33 | US9611277...)
Show SMILES Fc1cccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c1-n1ccnn1
Show InChI InChI=1/C21H17F4N5O2/c22-15-3-1-2-14(19(15)30-7-6-27-28-30)20(31)29-11-12-8-16(29)17(9-12)32-18-5-4-13(10-26-18)21(23,24)25/h1-7,10,12,16-17H,8-9,11H2
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3.50E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143791
PNG
(US10183953, Example 52 | US8969352, 52 | US9611277...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ncccc3C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-4-5-15(30-26-7-8-27-30)18(28-12)20(31)29-11-13-9-16(29)17(10-13)32-19-14(21(22,23)24)3-2-6-25-19/h2-8,13,16-17H,9-11H2,1H3
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4.00E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143780
PNG
(US10183953, Example 41 | US8969352, 41 | US9611277...)
Show SMILES Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3
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4.40E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143742
PNG
(US10183953, Example 1 | US8969352, 1 | US9611277, ...)
Show SMILES FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1
Show InChI InChI=1/C20H17F3N6O2/c21-20(22,23)17-9-25-18(10-24-17)31-16-8-12-7-15(16)28(11-12)19(30)13-3-1-2-4-14(13)29-26-5-6-27-29/h1-6,9-10,12,15-16H,7-8,11H2
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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143781
PNG
(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Show InChI InChI=1/C21H18F3N3O2/c22-21(23,24)14-4-5-18(26-10-14)29-17-9-12-8-16(17)27(11-12)20(28)15-3-1-2-13-6-7-25-19(13)15/h1-7,10,12,16-17,25H,8-9,11H2
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5.80E+3n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143744
PNG
(US10183953, Example 3 | US8969352, 3 | US9611277, ...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C23H21F3N4O3/c1-2-32-21-20(15-6-4-3-5-14(15)9-29-21)22(31)30-12-13-7-16(30)17(8-13)33-19-11-27-18(10-28-19)23(24,25)26/h3-6,9-11,13,16-17H,2,7-8,12H2,1H3
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8.90E+3n/an/an/an/an/an/an/an/a



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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143743
PNG
(US10183953, Example 2 | US8969352, 2 | US9611277, ...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3cnc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C20H18F3N7O2/c1-11-2-3-13(30-26-4-5-27-30)18(28-11)19(31)29-10-12-6-14(29)15(7-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-5,8-9,12,14-15H,6-7,10H2,1H3
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1.00E+4n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143745
PNG
(US10183953, Example 4 | US8969352, 4 | US9611277, ...)
Show SMILES Cc1cnc(C(=O)N2CC3CC(Oc4cnc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C20H18F3N7O2/c1-11-4-14(30-27-2-3-28-30)18(26-7-11)19(31)29-10-12-5-13(29)15(6-12)32-17-9-24-16(8-25-17)20(21,22)23/h2-4,7-9,12-13,15H,5-6,10H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143780
PNG
(US10183953, Example 41 | US8969352, 41 | US9611277...)
Show SMILES Cc1cnn(C)c1-c1ccccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C24H23F3N4O2/c1-14-11-29-30(2)22(14)17-5-3-4-6-18(17)23(32)31-13-15-9-19(31)20(10-15)33-21-8-7-16(12-28-21)24(25,26)27/h3-8,11-12,15,19-20H,9-10,13H2,1-2H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143760
PNG
(US10183953, Example 21 | US8969352, 21 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2
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US Patent


Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143751
PNG
(US10183953, Example 12 | US8969352, 12 | US9611277...)
Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-c1ncccn1
Show InChI InChI=1/C24H21F3N4O3/c1-33-16-4-5-17(18(11-16)22-28-7-2-8-29-22)23(32)31-13-14-9-19(31)20(10-14)34-21-6-3-15(12-30-21)24(25,26)27/h2-8,11-12,14,19-20H,9-10,13H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143761
PNG
(US10183953, Example 25 | US8969352, 22 | US8969352...)
Show SMILES Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(30-26-6-7-27-30)19(28-12)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



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Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143768
PNG
(US10183953, Example 29 | US8969352, 29 | US9611277...)
Show SMILES Cc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(n1)-n1nccn1
Show InChI InChI=1/C21H19F3N6O2/c1-12-2-4-15(19(28-12)30-26-6-7-27-30)20(31)29-11-13-8-16(29)17(9-13)32-18-5-3-14(10-25-18)21(22,23)24/h2-7,10,13,16-17H,8-9,11H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM143760
PNG
(US10183953, Example 21 | US8969352, 21 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2cnnc2)nc1
Show InChI InChI=1/C21H18F3N5O2/c22-21(23,24)14-5-6-19(25-9-14)31-18-8-13-7-17(18)29(10-13)20(30)15-3-1-2-4-16(15)28-11-26-27-12-28/h1-6,9,11-13,17-18H,7-8,10H2
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>1.00E+4n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143752
PNG
(US10183953, Example 13 | US8969352, 13 | US9611277...)
Show SMILES COc1ccc(C(=O)N2CC3CC(Oc4ccc(cn4)C(F)(F)F)C2C3)c(c1)-n1nccn1
Show InChI InChI=1/C22H20F3N5O3/c1-32-15-3-4-16(17(10-15)30-27-6-7-28-30)21(31)29-12-13-8-18(29)19(9-13)33-20-5-2-14(11-26-20)22(23,24)25/h2-7,10-11,13,18-19H,8-9,12H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 2 (OX2)


(Rattus norvegicus (Rat))
BDBM143770
PNG
(US10183953, Example 31 | US8969352, 31 | US9611277...)
Show SMILES COc1c(F)cccc1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2
Show InChI InChI=1/C20H18F4N2O3/c1-28-18-13(3-2-4-14(18)21)19(27)26-10-11-7-15(26)16(8-11)29-17-6-5-12(9-25-17)20(22,23)24/h2-6,9,11,15-16H,7-8,10H2,1H3
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Assay Description
Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...


US Patent US9845333 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%