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Patent code US9850225

Compile Data Set for Download or QSAR

Found 378 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363393
PNG
(N-(2-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin...)
Show SMILES CC(=O)NCCNCc1cc(C)c(OCc2cccc(-c3ccc4OCCOc4c3)c2C#N)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C35H33N5O5/c1-23-12-29(20-38-8-9-40-24(2)41)34(44-21-26-13-25(16-36)18-39-19-26)15-33(23)45-22-28-4-3-5-30(31(28)17-37)27-6-7-32-35(14-27)43-11-10-42-32/h3-7,12-15,18-19,38H,8-11,20-22H2,1-2H3,(H,40,41)
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n/an/a 0.920n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363331
PNG
((S)-4-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-...)
Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CNC[C@@H](O)CC(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C34H32ClN3O7/c1-21-25(3-2-4-28(21)24-5-6-30-33(11-24)43-8-7-42-30)20-45-32-13-31(44-19-23-9-22(14-36)15-37-16-23)26(10-29(32)35)17-38-18-27(39)12-34(40)41/h2-6,9-11,13,15-16,27,38-39H,7-8,12,17-20H2,1H3,(H,40,41)/t27-/s2
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n/an/a 1.19n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM50239948
PNG
(CHEMBL4071326 | US9850225, Example 1166)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3C[C@H](O)C[C@@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H33ClN2O7/c1-22-26(6-3-7-29(22)25-8-9-32-35(14-25)44-11-10-43-32)21-46-34-16-33(45-20-24-5-2-4-23(12-24)17-38)27(13-30(34)37)18-39-19-28(40)15-31(39)36(41)42/h2-9,12-14,16,28,31,40H,10-11,15,18-21H2,1H3,(H,41,42)/t28-,31-/s2
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363278
PNG
((2S,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3C[C@H](O)C[C@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H33ClN2O7/c1-22-26(6-3-7-29(22)25-8-9-32-35(14-25)44-11-10-43-32)21-46-34-16-33(45-20-24-5-2-4-23(12-24)17-38)27(13-30(34)37)18-39-19-28(40)15-31(39)36(41)42/h2-9,12-14,16,28,31,40H,10-11,15,18-21H2,1H3,(H,41,42)/t28-,31+/s2
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n/an/a 1.85n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363373
PNG
((R)-1-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-...)
Show SMILES Cc1cc(CN2CCCC[C@@H]2C(O)=O)c(OCc2cncc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1
Show InChI InChI=1/C37H37N3O6/c1-24-14-30(21-40-11-4-3-8-32(40)37(41)42)35(45-22-27-15-26(18-38)19-39-20-27)17-34(24)46-23-29-6-5-7-31(25(29)2)28-9-10-33-36(16-28)44-13-12-43-33/h5-7,9-10,14-17,19-20,32H,3-4,8,11-13,21-23H2,1-2H3,(H,41,42)/t32-/s2
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n/an/a 1.88n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363064
PNG
((R)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo...)
Show SMILES Cc1cc(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc(OCc2cccc(c2)C#N)c1CN[C@](C)(CO)C(O)=O
Show InChI InChI=1/C36H36N2O7/c1-23-14-29(44-21-28-8-5-9-30(24(28)2)27-10-11-32-34(16-27)43-13-12-42-32)17-33(31(23)19-38-36(3,22-39)35(40)41)45-20-26-7-4-6-25(15-26)18-37/h4-11,14-17,38-39H,12-13,19-22H2,1-3H3,(H,40,41)/t36-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363286
PNG
((R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN[C@H](CCO)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H33ClN2O7/c1-22-26(6-3-7-28(22)25-8-9-31-34(16-25)43-13-12-42-31)21-45-33-17-32(44-20-24-5-2-4-23(14-24)18-37)27(15-29(33)36)19-38-30(10-11-39)35(40)41/h2-9,14-17,30,38-39H,10-13,19-21H2,1H3,(H,40,41)/t30-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363080
PNG
((R)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1&#...)
Show SMILES Cc1c(COc2ccc(CN[C@H](CO)C(O)=O)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccccc1
Show InChI InChI=1/C32H30N2O5/c1-22-27(11-6-12-29(22)25-9-3-2-4-10-25)21-38-28-14-13-26(18-34-30(19-35)32(36)37)31(16-28)39-20-24-8-5-7-23(15-24)17-33/h2-16,30,34-35H,18-21H2,1H3,(H,36,37)/t30-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363251
PNG
(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dih...)
Show SMILES CN(C)CC(NCc1cc(Cl)c(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1/C36H36ClN3O6/c1-23-27(8-5-9-29(23)26-10-11-32-35(16-26)44-13-12-43-32)22-46-34-17-33(45-21-25-7-4-6-24(14-25)18-38)28(15-30(34)37)19-39-31(36(41)42)20-40(2)3/h4-11,14-17,31,39H,12-13,19-22H2,1-3H3,(H,41,42)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363270
PNG
((2S,3R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCC[C@H]([C@H]3C(O)=O)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C38H35ClN2O8/c1-23-27(7-3-8-29(23)26-10-11-32-35(17-26)47-14-13-46-32)22-49-34-18-33(48-21-25-6-2-5-24(15-25)19-40)28(16-31(34)39)20-41-12-4-9-30(37(42)43)36(41)38(44)45/h2-3,5-8,10-11,15-18,30,36H,4,9,12-14,20-22H2,1H3,(H,42,43)(H,44,45)/t30-,36+/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363287
PNG
((R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN[C@H](Cc3cscn3)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C37H32ClN3O6S/c1-23-27(6-3-7-30(23)26-8-9-33-36(14-26)45-11-10-44-33)20-47-35-16-34(46-19-25-5-2-4-24(12-25)17-39)28(13-31(35)38)18-40-32(37(42)43)15-29-21-48-22-41-29/h2-9,12-14,16,21-22,32,40H,10-11,15,18-20H2,1H3,(H,42,43)/t32-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363294
PNG
(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dih...)
Show SMILES CC(C)C(CO)(NCc1cc(Cl)c(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1/C37H37ClN2O7/c1-23(2)37(22-41,36(42)43)40-19-29-15-31(38)34(17-33(29)46-20-26-7-4-6-25(14-26)18-39)47-21-28-8-5-9-30(24(28)3)27-10-11-32-35(16-27)45-13-12-44-32/h4-11,14-17,23,40-41H,12-13,19-22H2,1-3H3,(H,42,43)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363301
PNG
((S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN[C@@H](Cc3ccccn3)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C39H34ClN3O6/c1-25-29(8-5-10-32(25)28-11-12-35-38(18-28)47-15-14-46-35)24-49-37-20-36(48-23-27-7-4-6-26(16-27)21-41)30(17-33(37)40)22-43-34(39(44)45)19-31-9-2-3-13-42-31/h2-13,16-18,20,34,43H,14-15,19,22-24H2,1H3,(H,44,45)/t34-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363328
PNG
(N-(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-...)
Show SMILES CC(=O)NCCNCc1cc(Cl)c(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C35H34ClN3O5/c1-23-28(7-4-8-30(23)27-9-10-32-35(17-27)42-14-13-41-32)22-44-34-18-33(43-21-26-6-3-5-25(15-26)19-37)29(16-31(34)36)20-38-11-12-39-24(2)40/h3-10,15-18,38H,11-14,20-22H2,1-2H3,(H,39,40)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363330
PNG
((R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-...)
Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C33H30ClN3O7/c1-20-24(3-2-4-26(20)23-5-6-29-32(11-23)42-8-7-41-29)19-44-31-12-30(43-18-22-9-21(13-35)14-36-15-22)25(10-27(31)34)16-37-28(17-38)33(39)40/h2-6,9-12,14-15,28,37-38H,7-8,16-19H2,1H3,(H,39,40)/t28-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363333
PNG
((S)-2-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4...)
Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN[C@@](C)(CO)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C34H32ClN3O7/c1-21-25(4-3-5-27(21)24-6-7-29-32(12-24)43-9-8-42-29)19-45-31-13-30(44-18-23-10-22(14-36)15-37-16-23)26(11-28(31)35)17-38-34(2,20-39)33(40)41/h3-7,10-13,15-16,38-39H,8-9,17-20H2,1-2H3,(H,40,41)/t34-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363335
PNG
((R)-2-(2-((5-bromopyridin-3-yl)methoxy)-5-chloro-4...)
Show SMILES Cc1c(COc2cc(OCc3cncc(Br)c3)c(CN[C@](C)(CO)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C33H32BrClN2O7/c1-20-23(4-3-5-26(20)22-6-7-28-31(12-22)42-9-8-41-28)18-44-30-13-29(43-17-21-10-25(34)16-36-14-21)24(11-27(30)35)15-37-33(2,19-38)32(39)40/h3-7,10-14,16,37-38H,8-9,15,17-19H2,1-2H3,(H,39,40)/t33-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363346
PNG
((S)-4-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrob...)
Show SMILES Cc1cc(CNC[C@@H](O)CC(O)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H36N2O7/c1-23-13-29(19-38-20-30(39)16-36(40)41)34(44-21-26-6-3-5-25(14-26)18-37)17-33(23)45-22-28-7-4-8-31(24(28)2)27-9-10-32-35(15-27)43-12-11-42-32/h3-10,13-15,17,30,38-39H,11-12,16,19-22H2,1-2H3,(H,40,41)/t30-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363351
PNG
((S)-4-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3...)
Show SMILES Cc1cc(CNC[C@@H](O)CC(O)=O)c(OCc2ccc(F)c(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H35FN2O7/c1-22-12-28(18-39-19-29(40)15-36(41)42)34(45-20-24-6-8-31(37)27(13-24)17-38)16-33(22)46-21-26-4-3-5-30(23(26)2)25-7-9-32-35(14-25)44-11-10-43-32/h3-9,12-14,16,29,39-40H,10-11,15,18-21H2,1-2H3,(H,41,42)/t29-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363368
PNG
((S)-4-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-...)
Show SMILES Cc1cc(CNC[C@@H](O)CC(O)=O)c(OCc2cncc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H35N3O7/c1-22-10-28(18-38-19-29(39)13-35(40)41)33(44-20-25-11-24(15-36)16-37-17-25)14-32(22)45-21-27-4-3-5-30(23(27)2)26-6-7-31-34(12-26)43-9-8-42-31/h3-7,10-12,14,16-17,29,38-39H,8-9,13,18-21H2,1-2H3,(H,40,41)/t29-/s2
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363374
PNG
(N-(2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[...)
Show SMILES CCc1cc(CNCCNC(C)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C37H39N3O5/c1-4-29-18-32(22-39-13-14-40-26(3)41)36(44-23-28-8-5-7-27(17-28)21-38)20-35(29)45-24-31-9-6-10-33(25(31)2)30-11-12-34-37(19-30)43-16-15-42-34/h5-12,17-20,39H,4,13-16,22-24H2,1-3H3,(H,40,41)
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363386
PNG
(N-(2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-d...)
Show SMILES CC(=O)NCCNCc1cc(Br)c(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C35H34BrN3O5/c1-23-28(7-4-8-30(23)27-9-10-32-35(17-27)42-14-13-41-32)22-44-34-18-33(43-21-26-6-3-5-25(15-26)19-37)29(16-31(34)36)20-38-11-12-39-24(2)40/h3-10,15-18,38H,11-14,20-22H2,1-2H3,(H,39,40)
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363389
PNG
((S)-1-(5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-d...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCC[C@H]3C(O)=O)cc2Br)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C37H35BrN2O6/c1-24-28(8-5-9-30(24)27-11-12-33-36(18-27)44-15-14-43-33)23-46-35-19-34(45-22-26-7-4-6-25(16-26)20-39)29(17-31(35)38)21-40-13-3-2-10-32(40)37(41)42/h4-9,11-12,16-19,32H,2-3,10,13-15,21-23H2,1H3,(H,41,42)/t32-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363390
PNG
((R)-2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN[C@](C)(CO)C(O)=O)cc2Br)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H33BrN2O7/c1-22-26(7-4-8-28(22)25-9-10-30-33(15-25)43-12-11-42-30)20-45-32-16-31(44-19-24-6-3-5-23(13-24)17-37)27(14-29(32)36)18-38-35(2,21-39)34(40)41/h3-10,13-16,38-39H,11-12,18-21H2,1-2H3,(H,40,41)/t35-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363393
PNG
(N-(2-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin...)
Show SMILES CC(=O)NCCNCc1cc(C)c(OCc2cccc(-c3ccc4OCCOc4c3)c2C#N)cc1OCc1cncc(c1)C#N
Show InChI InChI=1S/C35H33N5O5/c1-23-12-29(20-38-8-9-40-24(2)41)34(44-21-26-13-25(16-36)18-39-19-26)15-33(23)45-22-28-4-3-5-30(31(28)17-37)27-6-7-32-35(14-27)43-11-10-42-32/h3-7,12-15,18-19,38H,8-11,20-22H2,1-2H3,(H,40,41)
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363401
PNG
((S)-4-((5-bromo-4-((2-cyano-3-(2,3-dihydrobenzo[b]...)
Show SMILES O[C@H](CNCc1cc(Br)c(OCc2cccc(-c3ccc4OCCOc4c3)c2C#N)cc1OCc1cccc(c1)C#N)CC(O)=O
Show InChI InChI=1/C35H30BrN3O7/c36-30-12-26(18-39-19-27(40)14-35(41)42)32(45-20-23-4-1-3-22(11-23)16-37)15-33(30)46-21-25-5-2-6-28(29(25)17-38)24-7-8-31-34(13-24)44-10-9-43-31/h1-8,11-13,15,27,39-40H,9-10,14,18-21H2,(H,41,42)/t27-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363434
PNG
((2S,4R)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methox...)
Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3CC[C@@H](O)C[C@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H34ClN3O7/c1-22-26(3-2-4-29(22)25-5-6-32-35(13-25)45-10-9-44-32)21-47-34-15-33(46-20-24-11-23(16-38)17-39-18-24)27(12-30(34)37)19-40-8-7-28(41)14-31(40)36(42)43/h2-6,11-13,15,17-18,28,31,41H,7-10,14,19-21H2,1H3,(H,42,43)/t28-,31+/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363444
PNG
(US9850225, Example 3004)
Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3C[C@@H](O)C[C@H]3C(O)=O)cc2F)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H32FN3O7/c1-21-25(3-2-4-28(21)24-5-6-31-34(11-24)44-8-7-43-31)20-46-33-13-32(45-19-23-9-22(14-37)15-38-16-23)26(10-29(33)36)17-39-18-27(40)12-30(39)35(41)42/h2-6,9-11,13,15-16,27,30,40H,7-8,12,17-20H2,1H3,(H,41,42)/t27-,30-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363446
PNG
(US9850225, Example 3006)
Show SMILES C[C@H]1C(O)CN(Cc2cc(F)c(OCc3cccc(c3C)-c3ccc4OCCOc4c3)cc2OCc2cncc(c2)C#N)[C@@H]1C(O)=O
Show InChI InChI=1/C36H34FN3O7/c1-21-26(4-3-5-28(21)25-6-7-31-34(12-25)45-9-8-44-31)20-47-33-13-32(46-19-24-10-23(14-38)15-39-16-24)27(11-29(33)37)17-40-18-30(41)22(2)35(40)36(42)43/h3-7,10-13,15-16,22,30,35,41H,8-9,17-20H2,1-2H3,(H,42,43)/t22-,30?,35-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363447
PNG
(US9850225, Example 3008 | ethyl (5-((4-chloro-5-((...)
Show SMILES CCOC(=O)Nc1cncc(COc2cc(OCc3cccc(c3C)-c3ccc4OCCOc4c3)c(Cl)cc2C=O)c1
Show InChI InChI=1S/C32H29ClN2O7/c1-3-38-32(37)35-25-11-21(15-34-16-25)18-41-29-14-30(27(33)12-24(29)17-36)42-19-23-5-4-6-26(20(23)2)22-7-8-28-31(13-22)40-10-9-39-28/h4-8,11-17H,3,9-10,18-19H2,1-2H3,(H,35,37)
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363460
PNG
((S)-2-((5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]di...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)S(C)(=O)=O)c(CN[C@@](C)(CO)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H36ClNO9S/c1-22-25(7-5-9-28(22)24-10-11-30-33(16-24)44-13-12-43-30)20-46-32-17-31(45-19-23-6-4-8-27(14-23)47(3,41)42)26(15-29(32)36)18-37-35(2,21-38)34(39)40/h4-11,14-17,37-38H,12-13,18-21H2,1-3H3,(H,39,40)/t35-/s2
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363065
PNG
((R)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo...)
Show SMILES Cc1cc(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc(OCc2cccc(c2)C#N)c1CN[C@H](CO)C(O)=O
Show InChI InChI=1/C35H34N2O7/c1-22-13-28(43-21-27-7-4-8-29(23(27)2)26-9-10-32-34(15-26)42-12-11-41-32)16-33(30(22)18-37-31(19-38)35(39)40)44-20-25-6-3-5-24(14-25)17-36/h3-10,13-16,31,37-38H,11-12,18-21H2,1-2H3,(H,39,40)/t31-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363081
PNG
(2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′...)
Show SMILES Cc1c(COc2ccc(CNC(CO)C(O)=O)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccccc1
Show InChI InChI=1/C32H30N2O5/c1-22-27(11-6-12-29(22)25-9-3-2-4-10-25)21-38-28-14-13-26(18-34-30(19-35)32(36)37)31(16-28)39-20-24-8-5-7-23(15-24)17-33/h2-16,30,34-35H,18-21H2,1H3,(H,36,37)
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363192
PNG
((S)-4-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo...)
Show SMILES Cc1c(COc2ccc(CNC[C@@H](O)CC(O)=O)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H34N2O7/c1-23-28(6-3-7-31(23)26-9-11-32-34(15-26)42-13-12-41-32)22-43-30-10-8-27(19-37-20-29(38)16-35(39)40)33(17-30)44-21-25-5-2-4-24(14-25)18-36/h2-11,14-15,17,29,37-38H,12-13,16,19-22H2,1H3,(H,39,40)/t29-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363193
PNG
((R)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo...)
Show SMILES Cc1c(COc2ccc(CN[C@H](CO)C(O)=O)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C34H32N2O7/c1-22-27(6-3-7-29(22)25-9-11-31-33(15-25)41-13-12-40-31)21-42-28-10-8-26(18-36-30(19-37)34(38)39)32(16-28)43-20-24-5-2-4-23(14-24)17-35/h2-11,14-16,30,36-37H,12-13,18-21H2,1H3,(H,38,39)/t30-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363195
PNG
(2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo...)
Show SMILES Cc1c(COc2ccc(CNC(C)(CO)C(O)=O)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H34N2O7/c1-23-28(7-4-8-30(23)26-10-12-31-33(16-26)42-14-13-41-31)21-43-29-11-9-27(19-37-35(2,22-38)34(39)40)32(17-29)44-20-25-6-3-5-24(15-25)18-36/h3-12,15-17,37-38H,13-14,19-22H2,1-2H3,(H,39,40)
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363202
PNG
((S)-3-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrob...)
Show SMILES Cc1c(COc2ccc(CN[C@H](CO)CC(O)=O)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H34N2O7/c1-23-28(6-3-7-31(23)26-9-11-32-34(15-26)42-13-12-41-32)22-43-30-10-8-27(19-37-29(20-38)16-35(39)40)33(17-30)44-21-25-5-2-4-24(14-25)18-36/h2-11,14-15,17,29,37-38H,12-13,16,19-22H2,1H3,(H,39,40)/t29-/s2
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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363203
PNG
((R)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrob...)
Show SMILES Cc1c(COc2ccc(CN[C@](C)(CO)C(O)=O)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C35H34N2O7/c1-23-28(7-4-8-30(23)26-10-12-31-33(16-26)42-14-13-41-31)21-43-29-11-9-27(19-37-35(2,22-38)34(39)40)32(17-29)44-20-25-6-3-5-24(15-25)18-36/h3-12,15-17,37-38H,13-14,19-22H2,1-2H3,(H,39,40)/t35-/s2
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363214
PNG
(2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-...)
Show SMILES COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OCc2cccc(c2)C#N)c1CNC(C)(CO)C(O)=O
Show InChI InChI=1/C34H34N2O6/c1-23-27(13-8-14-29(23)26-11-5-4-6-12-26)21-41-28-16-31(40-3)30(19-36-34(2,22-37)33(38)39)32(17-28)42-20-25-10-7-9-24(15-25)18-35/h4-17,36-37H,19-22H2,1-3H3,(H,38,39)
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363218
PNG
((S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrob...)
Show SMILES COc1cc(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc(OCc2cccc(c2)C#N)c1CN[C@@H](CO)C(O)=O
Show InChI InChI=1/C35H34N2O8/c1-22-26(7-4-8-28(22)25-9-10-31-34(14-25)43-12-11-42-31)21-44-27-15-32(41-2)29(18-37-30(19-38)35(39)40)33(16-27)45-20-24-6-3-5-23(13-24)17-36/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40)/t30-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363223
PNG
((R)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]diox...)
Show SMILES OC[C@@H](NCc1ccc(OCc2cccc(c2Cl)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1/C33H29ClN2O7/c34-32-25(5-2-6-27(32)23-8-10-29-31(14-23)41-12-11-40-29)20-42-26-9-7-24(17-36-28(18-37)33(38)39)30(15-26)43-19-22-4-1-3-21(13-22)16-35/h1-10,13-15,28,36-37H,11-12,17-20H2,(H,38,39)/t28-/s2
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363230
PNG
((R)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]diox...)
Show SMILES Cc1cc(CN[C@H](CO)C(O)=O)c(OCc2cncc(c2)C#N)cc1OCc1cccc(c1Cl)-c1ccc2OCCOc2c1
Show InChI InChI=1/C33H30ClN3O7/c1-20-9-25(16-37-27(17-38)33(39)40)30(43-18-22-10-21(13-35)14-36-15-22)12-29(20)44-19-24-3-2-4-26(32(24)34)23-5-6-28-31(11-23)42-8-7-41-28/h2-6,9-12,14-15,27,37-38H,7-8,16-19H2,1H3,(H,39,40)/t27-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363232
PNG
((R)-1-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]diox...)
Show SMILES Cc1cc(CN2CCCC[C@@H]2C(O)=O)c(OCc2cncc(c2)C#N)cc1OCc1cccc(c1Cl)-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H34ClN3O6/c1-23-13-28(20-40-10-3-2-7-30(40)36(41)42)33(45-21-25-14-24(17-38)18-39-19-25)16-32(23)46-22-27-5-4-6-29(35(27)37)26-8-9-31-34(15-26)44-12-11-43-31/h4-6,8-9,13-16,18-19,30H,2-3,7,10-12,20-22H2,1H3,(H,41,42)/t30-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363255
PNG
((S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN[C@@H](Cc3cn(C)cn3)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C38H35ClN4O6/c1-24-28(7-4-8-31(24)27-9-10-34-37(15-27)47-12-11-46-34)22-49-36-17-35(48-21-26-6-3-5-25(13-26)18-40)29(14-32(36)39)19-41-33(38(44)45)16-30-20-43(2)23-42-30/h3-10,13-15,17,20,23,33,41H,11-12,16,19,21-22H2,1-2H3,(H,44,45)/t33-/s2
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363268
PNG
(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dih...)
Show SMILES CC(N(C)Cc1cc(Cl)c(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1/C35H33ClN2O6/c1-22-27(8-5-9-29(22)26-10-11-31-34(16-26)42-13-12-41-31)21-44-33-17-32(43-20-25-7-4-6-24(14-25)18-37)28(15-30(33)36)19-38(3)23(2)35(39)40/h4-11,14-17,23H,12-13,19-21H2,1-3H3,(H,39,40)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363285
PNG
((2S,3R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CC[C@@H](O)[C@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H33ClN2O7/c1-22-26(6-3-7-28(22)25-8-9-31-34(16-25)44-13-12-43-31)21-46-33-17-32(45-20-24-5-2-4-23(14-24)18-38)27(15-29(33)37)19-39-11-10-30(40)35(39)36(41)42/h2-9,14-17,30,35,40H,10-13,19-21H2,1H3,(H,41,42)/t30-,35+/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363292
PNG
(3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CNCC(O)CN3CCOCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C38H40ClN3O6/c1-26-30(6-3-7-33(26)29-8-9-35-38(18-29)46-15-14-45-35)25-48-37-19-36(47-24-28-5-2-4-27(16-28)20-40)31(17-34(37)39)21-41-22-32(43)23-42-10-12-44-13-11-42/h2-9,16-19,32,41,43H,10-15,21-25H2,1H3
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363310
PNG
(3-((2-((((1H-tetrazol-5-yl)methyl)amino)methyl)-4-...)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CNCc3nnn[nH]3)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1S/C33H29ClN6O4/c1-21-25(6-3-7-27(21)24-8-9-29-32(14-24)42-11-10-41-29)20-44-31-15-30(43-19-23-5-2-4-22(12-23)16-35)26(13-28(31)34)17-36-18-33-37-39-40-38-33/h2-9,12-15,36H,10-11,17-20H2,1H3,(H,37,38,39,40)
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363334
PNG
((S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4...)
Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3CCCC[C@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C36H34ClN3O6/c1-23-27(5-4-6-29(23)26-8-9-32-35(15-26)44-12-11-43-32)22-46-34-16-33(45-21-25-13-24(17-38)18-39-19-25)28(14-30(34)37)20-40-10-3-2-7-31(40)36(41)42/h4-6,8-9,13-16,18-19,31H,2-3,7,10-12,20-22H2,1H3,(H,41,42)/t31-/s2
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363337
PNG
((S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4...)
Show SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3CCCC[C@H]3C(=O)NS(C)(=O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
Show InChI InChI=1/C37H37ClN4O7S/c1-24-28(6-5-7-30(24)27-9-10-33-36(16-27)47-13-12-46-33)23-49-35-17-34(48-22-26-14-25(18-39)19-40-20-26)29(15-31(35)38)21-42-11-4-3-8-32(42)37(43)41-50(2,44)45/h5-7,9-10,14-17,19-20,32H,3-4,8,11-13,21-23H2,1-2H3,(H,41,43)/t32-/s2
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Bristol-Myers Squibb Company

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Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)

More data for this
Ligand-Target Pair
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