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Patent code US9856220

Compile Data Set for Download or QSAR
Found 125 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363819
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)N[C@H]2CCc3ccccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C26H30N2O4/c1-5-17(6-2)28-15-21(19-13-23(31-3)24(32-4)14-20(19)26(28)30)25(29)27-22-12-11-16-9-7-8-10-18(16)22/h7-10,13-15,17,22H,5-6,11-12H2,1-4H3,(H,27,29)/t22-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363832
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccccc2S(=O)(=O)N2CCN(C)CC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C29H38N4O6S/c1-6-21(7-2)33-19-24(22-16-25(38-4)26(39-5)17-23(22)29(33)35)28(34)30-18-20-10-8-9-11-27(20)40(36,37)32-14-12-31(3)13-15-32/h8-11,16-17,19,21H,6-7,12-15,18H2,1-5H3,(H,30,34)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363854
PNG
(6,7-Dimethoxy-N-(6-methoxy-2,3-dihydro-1H-inden-1-...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3ccc(OC)cc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C27H32N2O5/c1-6-17(7-2)29-15-22(20-13-24(33-4)25(34-5)14-21(20)27(29)31)26(30)28-23-11-9-16-8-10-18(32-3)12-19(16)23/h8,10,12-15,17,23H,6-7,9,11H2,1-5H3,(H,28,30)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363782
PNG
(2-Ethyl-7-methoxy-1-oxo-6-(2-quinolin-2-yl-ethoxy)...)
Show SMILES CCCCNC(=O)c1cn(CC)c(=O)c2cc(OC)c(OCCc3ccc4ccccc4n3)cc12
Show InChI InChI=1S/C28H31N3O4/c1-4-6-14-29-27(32)23-18-31(5-2)28(33)22-17-25(34-3)26(16-21(22)23)35-15-13-20-12-11-19-9-7-8-10-24(19)30-20/h7-12,16-18H,4-6,13-15H2,1-3H3,(H,29,32)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363828
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccccc2S(=O)(=O)N2CCOCC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C28H35N3O7S/c1-5-20(6-2)31-18-23(21-15-24(36-3)25(37-4)16-22(21)28(31)33)27(32)29-17-19-9-7-8-10-26(19)39(34,35)30-11-13-38-14-12-30/h7-10,15-16,18,20H,5-6,11-14,17H2,1-4H3,(H,29,32)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363781
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3ccccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C26H30N2O4/c1-5-17(6-2)28-15-21(19-13-23(31-3)24(32-4)14-20(19)26(28)30)25(29)27-22-12-11-16-9-7-8-10-18(16)22/h7-10,13-15,17,22H,5-6,11-12H2,1-4H3,(H,27,29)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363821
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NC2COc3ccccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C25H28N2O5/c1-5-15(6-2)27-13-19(17-11-22(30-3)23(31-4)12-18(17)25(27)29)24(28)26-20-14-32-21-10-8-7-9-16(20)21/h7-13,15,20H,5-6,14H2,1-4H3,(H,26,28)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363780
PNG
(3-Ethyl-6,7-dimethoxy-4-oxo-3,4-dihydro-phthalazin...)
Show SMILES CCn1nc(C(=O)NC2CCc3ncccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C21H22N4O4/c1-4-25-21(27)14-11-18(29-3)17(28-2)10-13(14)19(24-25)20(26)23-16-8-7-15-12(16)6-5-9-22-15/h5-6,9-11,16H,4,7-8H2,1-3H3,(H,23,26)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363851
PNG
(6,7-Dimethoxy-N-(5-methyl-2,3-dihydro-1H-inden-1-y...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3cc(C)ccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C27H32N2O4/c1-6-18(7-2)29-15-22(20-13-24(32-4)25(33-5)14-21(20)27(29)31)26(30)28-23-11-9-17-12-16(3)8-10-19(17)23/h8,10,12-15,18,23H,6-7,9,11H2,1-5H3,(H,28,30)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363794
PNG
(2-Ethyl-6,7-dimethoxy-N-(4-methylbenzyl)-1-oxo-1,2...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H24N2O4/c1-5-24-13-18(21(25)23-12-15-8-6-14(2)7-9-15)16-10-19(27-3)20(28-4)11-17(16)22(24)26/h6-11,13H,5,12H2,1-4H3,(H,23,25)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363888
PNG
(N-Butyl-6,7-dimethoxy-1-oxo-2-[2-(2-quinolyl)ethyl...)
Show SMILES CCCCNC(=O)c1cn(CCc2ccc3ccccc3n2)c(=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H29N3O4/c1-4-5-13-28-26(31)22-17-30(14-12-19-11-10-18-8-6-7-9-23(18)29-19)27(32)21-16-25(34-3)24(33-2)15-20(21)22/h6-11,15-17H,4-5,12-14H2,1-3H3,(H,28,31)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363852
PNG
(6,7-Dimethoxy-N-(4-methyl-2,3-dihydro-1H-inden-1-y...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3c2cccc3C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C27H32N2O4/c1-6-17(7-2)29-15-22(20-13-24(32-4)25(33-5)14-21(20)27(29)31)26(30)28-23-12-11-18-16(3)9-8-10-19(18)23/h8-10,13-15,17,23H,6-7,11-12H2,1-5H3,(H,28,30)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363831
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CSc3ccccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C25H28N2O4S/c1-5-15(6-2)27-13-19(17-11-21(30-3)22(31-4)12-18(17)25(27)29)24(28)26-20-14-32-23-10-8-7-9-16(20)23/h7-13,15,20H,5-6,14H2,1-4H3,(H,26,28)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363820
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3sccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C24H28N2O4S/c1-5-14(6-2)26-13-18(23(27)25-19-7-8-22-15(19)9-10-31-22)16-11-20(29-3)21(30-4)12-17(16)24(26)28/h9-14,19H,5-8H2,1-4H3,(H,25,27)
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n/an/a<100n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363795
PNG
(2-Ethyl-6,7-dimethoxy-N-(2-methylbenzyl)-1-oxo-1,2...)
Show SMILES CCn1cc(C(=O)NCc2ccccc2C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H24N2O4/c1-5-24-13-18(21(25)23-12-15-9-7-6-8-14(15)2)16-10-19(27-3)20(28-4)11-17(16)22(24)26/h6-11,13H,5,12H2,1-4H3,(H,23,25)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363860
PNG
(6,7-Dimethoxy-N-(4-methylbenzyl)-1-oxo-2-(pentan-3...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccc(C)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C25H30N2O4/c1-6-18(7-2)27-15-21(24(28)26-14-17-10-8-16(3)9-11-17)19-12-22(30-4)23(31-5)13-20(19)25(27)29/h8-13,15,18H,6-7,14H2,1-5H3,(H,26,28)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363777
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NC(C)c2ccc(F)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C22H23FN2O4/c1-5-25-12-18(21(26)24-13(2)14-6-8-15(23)9-7-14)16-10-19(28-3)20(29-4)11-17(16)22(25)27/h6-13H,5H2,1-4H3,(H,24,26)
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n/an/a 150n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363778
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NC2CCc3ccccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C23H24N2O4/c1-4-25-13-18(16-11-20(28-2)21(29-3)12-17(16)23(25)27)22(26)24-19-10-9-14-7-5-6-8-15(14)19/h5-8,11-13,19H,4,9-10H2,1-3H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363823
PNG
(2-sec-Butyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoqui...)
Show SMILES CCC(C)n1cc(C(=O)NC2CCc3ccccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C25H28N2O4/c1-5-15(2)27-14-20(18-12-22(30-3)23(31-4)13-19(18)25(27)29)24(28)26-21-11-10-16-8-6-7-9-17(16)21/h6-9,12-15,21H,5,10-11H2,1-4H3,(H,26,28)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363865
PNG
(6,7-Dimethoxy-N-((3-methylfuran-2-yl)methyl)-1-oxo...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2occc2C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H28N2O5/c1-6-15(7-2)25-13-18(22(26)24-12-21-14(3)8-9-30-21)16-10-19(28-4)20(29-5)11-17(16)23(25)27/h8-11,13,15H,6-7,12H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363856
PNG
(6,7-Dimethoxy-N-((3-methylthiophen-2-yl)methyl)-1-...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2sccc2C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H28N2O4S/c1-6-15(7-2)25-13-18(22(26)24-12-21-14(3)8-9-30-21)16-10-19(28-4)20(29-5)11-17(16)23(25)27/h8-11,13,15H,6-7,12H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363861
PNG
(6,7-Dimethoxy-1-oxo-2-(pentan-3-yl)-N-(pyridin-2-y...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccccn2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H27N3O4/c1-5-16(6-2)26-14-19(22(27)25-13-15-9-7-8-10-24-15)17-11-20(29-3)21(30-4)12-18(17)23(26)28/h7-12,14,16H,5-6,13H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363776
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2cc(F)cc(F)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H20F2N2O4/c1-4-25-11-17(20(26)24-10-12-5-13(22)7-14(23)6-12)15-8-18(28-2)19(29-3)9-16(15)21(25)27/h5-9,11H,4,10H2,1-3H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363816
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccc(F)c(F)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H26F2N2O4/c1-5-15(6-2)28-13-18(23(29)27-12-14-7-8-19(25)20(26)9-14)16-10-21(31-3)22(32-4)11-17(16)24(28)30/h7-11,13,15H,5-6,12H2,1-4H3,(H,27,29)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363817
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCC2CCCCC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H34N2O4/c1-5-17(6-2)26-15-20(23(27)25-14-16-10-8-7-9-11-16)18-12-21(29-3)22(30-4)13-19(18)24(26)28/h12-13,15-17H,5-11,14H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363848
PNG
(6,7-Dimethoxy-N-((5-methylfuran-2-yl)methyl)-1-oxo...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccc(C)o2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H28N2O5/c1-6-15(7-2)25-13-19(22(26)24-12-16-9-8-14(3)30-16)17-10-20(28-4)21(29-5)11-18(17)23(25)27/h8-11,13,15H,6-7,12H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363797
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-p-tolyl-1,2-dihydroi...)
Show SMILES CCn1cc(C(=O)Nc2ccc(C)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H22N2O4/c1-5-23-12-17(20(24)22-14-8-6-13(2)7-9-14)15-10-18(26-3)19(27-4)11-16(15)21(23)25/h6-12H,5H2,1-4H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363858
PNG
(6,7-Dimethoxy-N-(6-methyl-2,3-dihydro-1H-inden-1-y...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3ccc(C)cc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C27H32N2O4/c1-6-18(7-2)29-15-22(20-13-24(32-4)25(33-5)14-21(20)27(29)31)26(30)28-23-11-10-17-9-8-16(3)12-19(17)23/h8-9,12-15,18,23H,6-7,10-11H2,1-5H3,(H,28,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363758
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCCCNC(=O)c1cn(CC)c(=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C18H24N2O4/c1-5-7-8-19-17(21)14-11-20(6-2)18(22)13-10-16(24-4)15(23-3)9-12(13)14/h9-11H,5-8H2,1-4H3,(H,19,21)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363815
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2cc(F)cc(F)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H26F2N2O4/c1-5-17(6-2)28-13-20(23(29)27-12-14-7-15(25)9-16(26)8-14)18-10-21(31-3)22(32-4)11-19(18)24(28)30/h7-11,13,17H,5-6,12H2,1-4H3,(H,27,29)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363835
PNG
(3-(1-Ethyl-propyl)-6,7-dimethoxy-4-oxo-3,4-dihydro...)
Show SMILES CCC(CC)n1nc(C(=O)NC2CCc3ncccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C24H28N4O4/c1-5-14(6-2)28-24(30)17-13-21(32-4)20(31-3)12-16(17)22(27-28)23(29)26-19-10-9-18-15(19)8-7-11-25-18/h7-8,11-14,19H,5-6,9-10H2,1-4H3,(H,26,29)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363836
PNG
(6,7-Dimethoxy-1-oxo-2-(pentan-3-yl)-N-(pyridin-3-y...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2cccnc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H27N3O4/c1-5-16(6-2)26-14-19(22(27)25-13-15-8-7-9-24-12-15)17-10-20(29-3)21(30-4)11-18(17)23(26)28/h7-12,14,16H,5-6,13H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363837
PNG
(6,7-Dimethoxy-N-((5-methylthiophen-2-yl)methyl)-1-...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccc(C)s2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H28N2O4S/c1-6-15(7-2)25-13-19(22(26)24-12-16-9-8-14(3)30-16)17-10-20(28-4)21(29-5)11-18(17)23(25)27/h8-11,13,15H,6-7,12H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363839
PNG
(N-((3,5-Dimethylisoxazol-4-yl)methyl)-6,7-dimethox...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2c(C)noc2C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H29N3O5/c1-7-15(8-2)26-12-19(22(27)24-11-18-13(3)25-31-14(18)4)16-9-20(29-5)21(30-6)10-17(16)23(26)28/h9-10,12,15H,7-8,11H2,1-6H3,(H,24,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363806
PNG
(N-(5,6-Dihydro-4H-cyclopenta[b]thiophen-4-yl)-2-et...)
Show SMILES CCn1cc(C(=O)NC2CCc3sccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C21H22N2O4S/c1-4-23-11-15(20(24)22-16-5-6-19-12(16)7-8-28-19)13-9-17(26-2)18(27-3)10-14(13)21(23)25/h7-11,16H,4-6H2,1-3H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363786
PNG
(N-(3-Chlorobenzyl)-2-ethyl-6,7-dimethoxy-1-oxo-1,2...)
Show SMILES CCn1cc(C(=O)NCc2cccc(Cl)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H21ClN2O4/c1-4-24-12-17(20(25)23-11-13-6-5-7-14(22)8-13)15-9-18(27-2)19(28-3)10-16(15)21(24)26/h5-10,12H,4,11H2,1-3H3,(H,23,25)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363822
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CC(=O)c3sccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C24H26N2O5S/c1-5-13(6-2)26-12-17(15-9-20(30-3)21(31-4)10-16(15)24(26)29)23(28)25-18-11-19(27)22-14(18)7-8-32-22/h7-10,12-13,18H,5-6,11H2,1-4H3,(H,25,28)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363844
PNG
((S)-N-(1-(4-fluorophenyl)ethyl)-6,7-dimethoxy-1-ox...)
Show SMILES CCC(CC)n1cc(C(=O)N[C@@H](C)c2ccc(F)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C25H29FN2O4/c1-6-18(7-2)28-14-21(24(29)27-15(3)16-8-10-17(26)11-9-16)19-12-22(31-4)23(32-5)13-20(19)25(28)30/h8-15,18H,6-7H2,1-5H3,(H,27,29)/t15-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363801
PNG
((S)-2-Ethyl-N-(1-(4-fluorophenyl)ethyl)-6,7-dimeth...)
Show SMILES CCn1cc(C(=O)N[C@@H](C)c2ccc(F)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H23FN2O4/c1-5-25-12-18(21(26)24-13(2)14-6-8-15(23)9-7-14)16-10-19(28-3)20(29-4)11-17(16)22(25)27/h6-13H,5H2,1-4H3,(H,24,26)/t13-/m0/s1
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363812
PNG
(7-Methoxy-1-oxo-2-(2-quinolin-2-yl-ethyl)-1,2-dihy...)
Show SMILES CCCCNC(=O)c1cn(CCc2ccc3ccccc3n2)c(=O)c2cc(OC)ccc12
Show InChI InChI=1S/C26H27N3O3/c1-3-4-14-27-25(30)23-17-29(26(31)22-16-20(32-2)11-12-21(22)23)15-13-19-10-9-18-7-5-6-8-24(18)28-19/h5-12,16-17H,3-4,13-15H2,1-2H3,(H,27,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363841
PNG
(6,7-Dimethoxy-N-((3-methylisoxazol-5-yl)methyl)-1-...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2cc(C)no2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H27N3O5/c1-6-14(7-2)25-12-18(21(26)23-11-15-8-13(3)24-30-15)16-9-19(28-4)20(29-5)10-17(16)22(25)27/h8-10,12,14H,6-7,11H2,1-5H3,(H,23,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363850
PNG
(N-(5-Fluoro-2,3-dihydro-1H-inden-1-yl)-6,7-dimetho...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3cc(F)ccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C26H29FN2O4/c1-5-17(6-2)29-14-21(19-12-23(32-3)24(33-4)13-20(19)26(29)31)25(30)28-22-10-7-15-11-16(27)8-9-18(15)22/h8-9,11-14,17,22H,5-7,10H2,1-4H3,(H,28,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363846
PNG
(6,7-Dimethoxy-N-((2-methylthiazol-4-yl)methyl)-1-o...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2csc(C)n2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H27N3O4S/c1-6-15(7-2)25-11-18(21(26)23-10-14-12-30-13(3)24-14)16-8-19(28-4)20(29-5)9-17(16)22(25)27/h8-9,11-12,15H,6-7,10H2,1-5H3,(H,23,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363775
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2ccc(F)c(F)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H20F2N2O4/c1-4-25-11-15(20(26)24-10-12-5-6-16(22)17(23)7-12)13-8-18(28-2)19(29-3)9-14(13)21(25)27/h5-9,11H,4,10H2,1-3H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363765
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2ccccc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H22N2O4/c1-4-23-13-17(20(24)22-12-14-8-6-5-7-9-14)15-10-18(26-2)19(27-3)11-16(15)21(23)25/h5-11,13H,4,12H2,1-3H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363789
PNG
(2-Ethyl-6,7-dimethoxy-N-(3-methoxyphenyl)-1-oxo-1,...)
Show SMILES CCn1cc(C(=O)Nc2cccc(OC)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H22N2O5/c1-5-23-12-17(20(24)22-13-7-6-8-14(9-13)26-2)15-10-18(27-3)19(28-4)11-16(15)21(23)25/h6-12H,5H2,1-4H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363840
PNG
(6,7-Dimethoxy-N-((5-methylthiazol-2-yl)methyl)-1-o...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ncc(C)s2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H27N3O4S/c1-6-14(7-2)25-12-17(21(26)24-11-20-23-10-13(3)30-20)15-8-18(28-4)19(29-5)9-16(15)22(25)27/h8-10,12,14H,6-7,11H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363834
PNG
(2-Ethyl-7-methoxy-1-oxo-1,2-dihydro-[2,6]naphthyri...)
Show SMILES CCn1cc(C(=O)NC2CCc3sccc23)c2cnc(OC)cc2c1=O
Show InChI InChI=1/C19H19N3O3S/c1-3-22-10-14(13-9-20-17(25-2)8-12(13)19(22)24)18(23)21-15-4-5-16-11(15)6-7-26-16/h6-10,15H,3-5H2,1-2H3,(H,21,23)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363845
PNG
(6,7-Dimethoxy-N-((4-methylthiazol-2-yl)methyl)-1-o...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2nc(C)cs2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H27N3O4S/c1-6-14(7-2)25-11-17(21(26)23-10-20-24-13(3)12-30-20)15-8-18(28-4)19(29-5)9-16(15)22(25)27/h8-9,11-12,14H,6-7,10H2,1-5H3,(H,23,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363833
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2nccs2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H25N3O4S/c1-5-13(6-2)24-12-16(20(25)23-11-19-22-7-8-29-19)14-9-17(27-3)18(28-4)10-15(14)21(24)26/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363855
PNG
(6,7-Dimethoxy-N-((4-methylthiophen-2-yl)methyl)-1-...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2cc(C)cs2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H28N2O4S/c1-6-15(7-2)25-12-19(22(26)24-11-16-8-14(3)13-30-16)17-9-20(28-4)21(29-5)10-18(17)23(25)27/h8-10,12-13,15H,6-7,11H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363813
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3ncccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C25H29N3O4/c1-5-15(6-2)28-14-19(17-12-22(31-3)23(32-4)13-18(17)25(28)30)24(29)27-21-10-9-20-16(21)8-7-11-26-20/h7-8,11-15,21H,5-6,9-10H2,1-4H3,(H,27,29)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363886
PNG
(2-Ethyl-6,7-dimethoxy-N-[(4-methyl-2-thienyl)methy...)
Show SMILES CCn1cc(C(=O)NCc2cc(C)cs2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C20H22N2O4S/c1-5-22-10-16(19(23)21-9-13-6-12(2)11-27-13)14-7-17(25-3)18(26-4)8-15(14)20(22)24/h6-8,10-11H,5,9H2,1-4H3,(H,21,23)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363785
PNG
(2-Ethyl-6,7-dimethoxy-N-(4-morpholinophenyl)-1-oxo...)
Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)N2CCOCC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H27N3O5/c1-4-26-15-20(18-13-21(30-2)22(31-3)14-19(18)24(26)29)23(28)25-16-5-7-17(8-6-16)27-9-11-32-12-10-27/h5-8,13-15H,4,9-12H2,1-3H3,(H,25,28)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363794
PNG
(2-Ethyl-6,7-dimethoxy-N-(4-methylbenzyl)-1-oxo-1,2...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H24N2O4/c1-5-24-13-18(21(25)23-12-15-8-6-14(2)7-9-15)16-10-19(27-3)20(28-4)11-17(16)22(24)26/h6-11,13H,5,12H2,1-4H3,(H,23,25)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363762
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCCCCNC(=O)c1cn(CC)c(=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C19H26N2O4/c1-5-7-8-9-20-18(22)15-12-21(6-2)19(23)14-11-17(25-4)16(24-3)10-13(14)15/h10-12H,5-9H2,1-4H3,(H,20,22)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363825
PNG
((+)-2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dih...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3ncccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C25H29N3O4/c1-5-15(6-2)28-14-19(17-12-22(31-3)23(32-4)13-18(17)25(28)30)24(29)27-21-10-9-20-16(21)8-7-11-26-20/h7-8,11-15,21H,5-6,9-10H2,1-4H3,(H,27,29)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363792
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-phenyl-1,2-dihydrois...)
Show SMILES CCn1cc(C(=O)Nc2ccccc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C20H20N2O4/c1-4-22-12-16(19(23)21-13-8-6-5-7-9-13)14-10-17(25-2)18(26-3)11-15(14)20(22)24/h5-12H,4H2,1-3H3,(H,21,23)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363800
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-(pyridin-4-yl)-1,2-d...)
Show SMILES CCn1cc(C(=O)Nc2ccncc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C19H19N3O4/c1-4-22-11-15(18(23)21-12-5-7-20-8-6-12)13-9-16(25-2)17(26-3)10-14(13)19(22)24/h5-11H,4H2,1-3H3,(H,20,21,23)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363857
PNG
(6,7-Dimethoxy-N-((5-methyloxazol-2-yl)methyl)-1-ox...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ncc(C)o2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H27N3O5/c1-6-14(7-2)25-12-17(21(26)24-11-20-23-10-13(3)30-20)15-8-18(28-4)19(29-5)9-16(15)22(25)27/h8-10,12,14H,6-7,11H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363872
PNG
(2-Ethyl-6,7-dimethoxy-N-[[4-methyl-2-(2,2,2-triflu...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OCC(F)(F)F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H25F3N2O5/c1-5-29-12-18(16-9-20(32-3)21(33-4)10-17(16)23(29)31)22(30)28-11-15-7-6-14(2)8-19(15)34-13-24(25,26)27/h6-10,12H,5,11,13H2,1-4H3,(H,28,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363874
PNG
(2-Ethyl-6,7-dimethoxy-N-[[2-(2-methoxyethoxy)-4-me...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OCCOC)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C25H30N2O6/c1-6-27-15-20(18-12-22(31-4)23(32-5)13-19(18)25(27)29)24(28)26-14-17-8-7-16(2)11-21(17)33-10-9-30-3/h7-8,11-13,15H,6,9-10,14H2,1-5H3,(H,26,28)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363876
PNG
(2-Ethyl-N-(2-isopropoxy-4-methylbenzyl)-6,7-dimeth...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OC(C)C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C25H30N2O5/c1-7-27-14-20(18-11-22(30-5)23(31-6)12-19(18)25(27)29)24(28)26-13-17-9-8-16(4)10-21(17)32-15(2)3/h8-12,14-15H,7,13H2,1-6H3,(H,26,28)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363879
PNG
(2-Ethyl-6,7-dimethoxy-N-(4-methyl-2-((tetrahydrofu...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OCC2CCCO2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C27H32N2O6/c1-5-29-15-22(20-12-24(32-3)25(33-4)13-21(20)27(29)31)26(30)28-14-18-9-8-17(2)11-23(18)35-16-19-7-6-10-34-19/h8-9,11-13,15,19H,5-7,10,14,16H2,1-4H3,(H,28,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363881
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-(thiazol-4-ylmethyl)...)
Show SMILES CCn1cc(C(=O)NCc2cscn2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C18H19N3O4S/c1-4-21-8-14(17(22)19-7-11-9-26-10-20-11)12-5-15(24-2)16(25-3)6-13(12)18(21)23/h5-6,8-10H,4,7H2,1-3H3,(H,19,22)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363889
PNG
(N-Indan-1-yl-6,7-dimethoxy-1-oxo-2-[2-(2-quinolyl)...)
Show SMILES COc1cc2c(cn(CCc3ccc4ccccc4n3)c(=O)c2cc1OC)C(=O)NC1CCc2ccccc12
Show InChI InChI=1/C32H29N3O4/c1-38-29-17-24-25(18-30(29)39-2)32(37)35(16-15-22-13-11-21-8-4-6-10-27(21)33-22)19-26(24)31(36)34-28-14-12-20-7-3-5-9-23(20)28/h3-11,13,17-19,28H,12,14-16H2,1-2H3,(H,34,36)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363766
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCC2CCCCC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H28N2O4/c1-4-23-13-17(20(24)22-12-14-8-6-5-7-9-14)15-10-18(26-2)19(27-3)11-16(15)21(23)25/h10-11,13-14H,4-9,12H2,1-3H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363853
PNG
(N-((2-Ethylthiazol-4-yl)methyl)-6,7-dimethoxy-1-ox...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2csc(CC)n2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H29N3O4S/c1-6-15(7-2)26-12-18(22(27)24-11-14-13-31-21(8-3)25-14)16-9-19(29-4)20(30-5)10-17(16)23(26)28/h9-10,12-13,15H,6-8,11H2,1-5H3,(H,24,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363796
PNG
(2-Ethyl-N-(4-fluorophenyl)-6,7-dimethoxy-1-oxo-1,2...)
Show SMILES CCn1cc(C(=O)Nc2ccc(F)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C20H19FN2O4/c1-4-23-11-16(19(24)22-13-7-5-12(21)6-8-13)14-9-17(26-2)18(27-3)10-15(14)20(23)25/h5-11H,4H2,1-3H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363804
PNG
(N-(5-Chloro-2,3-dihydro-1H-inden-1-yl)-2-ethyl-6,7...)
Show SMILES CCn1cc(C(=O)NC2CCc3cc(Cl)ccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C23H23ClN2O4/c1-4-26-12-18(16-10-20(29-2)21(30-3)11-17(16)23(26)28)22(27)25-19-8-5-13-9-14(24)6-7-15(13)19/h6-7,9-12,19H,4-5,8H2,1-3H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363808
PNG
(2-Ethyl-6,7-dimethoxy-N-(4-methyl-2,3-dihydro-1H-i...)
Show SMILES CCn1cc(C(=O)NC2CCc3c2cccc3C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C24H26N2O4/c1-5-26-13-19(17-11-21(29-3)22(30-4)12-18(17)24(26)28)23(27)25-20-10-9-15-14(2)7-6-8-16(15)20/h6-8,11-13,20H,5,9-10H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363809
PNG
(2-Ethyl-6,7-dimethoxy-N-(5-methyl-2,3-dihydro-1H-i...)
Show SMILES CCn1cc(C(=O)NC2CCc3cc(C)ccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C24H26N2O4/c1-5-26-13-19(17-11-21(29-3)22(30-4)12-18(17)24(26)28)23(27)25-20-9-7-15-10-14(2)6-8-16(15)20/h6,8,10-13,20H,5,7,9H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363862
PNG
(N-((5-Cyanofuran-2-yl)methyl)-6,7-dimethoxy-1-oxo-...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccc(o2)C#N)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H25N3O5/c1-5-14(6-2)26-13-19(22(27)25-12-16-8-7-15(11-24)31-16)17-9-20(29-3)21(30-4)10-18(17)23(26)28/h7-10,13-14H,5-6,12H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363884
PNG
(2-Ethyl-6,7-dimethoxy-N-[(2-methylthiazol-4-yl)met...)
Show SMILES CCn1cc(C(=O)NCc2csc(C)n2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C19H21N3O4S/c1-5-22-9-15(18(23)20-8-12-10-27-11(2)21-12)13-6-16(25-3)17(26-4)7-14(13)19(22)24/h6-7,9-10H,5,8H2,1-4H3,(H,20,23)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363814
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccccc2CN(C)C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C27H35N3O4/c1-7-20(8-2)30-17-23(21-13-24(33-5)25(34-6)14-22(21)27(30)32)26(31)28-15-18-11-9-10-12-19(18)16-29(3)4/h9-14,17,20H,7-8,15-16H2,1-6H3,(H,28,31)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363787
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-m-tolyl-1,2-dihydroi...)
Show SMILES CCn1cc(C(=O)Nc2cccc(C)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H22N2O4/c1-5-23-12-17(20(24)22-14-8-6-7-13(2)9-14)15-10-18(26-3)19(27-4)11-16(15)21(23)25/h6-12H,5H2,1-4H3,(H,22,24)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363810
PNG
(2-Ethyl-6,7-dimethoxy-N-(6-methoxy-2,3-dihydro-1H-...)
Show SMILES CCn1cc(C(=O)NC2CCc3ccc(OC)cc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C24H26N2O5/c1-5-26-13-19(17-11-21(30-3)22(31-4)12-18(17)24(26)28)23(27)25-20-9-7-14-6-8-15(29-2)10-16(14)20/h6,8,10-13,20H,5,7,9H2,1-4H3,(H,25,27)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363871
PNG
(N-[(2,3-Difluoro-4-methyl-phenyl)methyl]-2-ethyl-6...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)c(F)c2F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H22F2N2O4/c1-5-26-11-16(14-8-17(29-3)18(30-4)9-15(14)22(26)28)21(27)25-10-13-7-6-12(2)19(23)20(13)24/h6-9,11H,5,10H2,1-4H3,(H,25,27)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363875
PNG
(N-(2-sec-Butoxy-4-methylbenzyl)-2-ethyl-6,7-dimeth...)
Show SMILES CCC(C)Oc1cc(C)ccc1CNC(=O)c1cn(CC)c(=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1/C26H32N2O5/c1-7-17(4)33-22-11-16(3)9-10-18(22)14-27-25(29)21-15-28(8-2)26(30)20-13-24(32-6)23(31-5)12-19(20)21/h9-13,15,17H,7-8,14H2,1-6H3,(H,27,29)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363763
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NC(C)CC(C)C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C20H28N2O4/c1-7-22-11-16(19(23)21-13(4)8-12(2)3)14-9-17(25-5)18(26-6)10-15(14)20(22)24/h9-13H,7-8H2,1-6H3,(H,21,23)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363774
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2c(F)cccc2F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H20F2N2O4/c1-4-25-11-15(20(26)24-10-14-16(22)6-5-7-17(14)23)12-8-18(28-2)19(29-3)9-13(12)21(25)27/h5-9,11H,4,10H2,1-3H3,(H,24,26)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363802
PNG
(2-Ethyl-6,7-dimethoxy-N-(6-methyl-2,3-dihydro-1H-i...)
Show SMILES CCn1cc(C(=O)NC2CCc3ccc(C)cc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C24H26N2O4/c1-5-26-13-19(17-11-21(29-3)22(30-4)12-18(17)24(26)28)23(27)25-20-9-8-15-7-6-14(2)10-16(15)20/h6-7,10-13,20H,5,8-9H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363864
PNG
(N-((5-Ethylthiophen-2-yl)methyl)-6,7-dimethoxy-1-o...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccc(CC)s2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H30N2O4S/c1-6-15(7-2)26-14-20(23(27)25-13-17-10-9-16(8-3)31-17)18-11-21(29-4)22(30-5)12-19(18)24(26)28/h9-12,14-15H,6-8,13H2,1-5H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363867
PNG
(6,7-Dimethoxy-N-((1-methyl-1H-pyrazol-3-yl)methyl)...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccn(C)n2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H28N4O4/c1-6-15(7-2)26-13-18(21(27)23-12-14-8-9-25(3)24-14)16-10-19(29-4)20(30-5)11-17(16)22(26)28/h8-11,13,15H,6-7,12H2,1-5H3,(H,23,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363873
PNG
(N-[[2-(Cyclopropylmethoxy)-4-methyl-phenyl]methyl]...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OCC2CC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C26H30N2O5/c1-5-28-14-21(19-11-23(31-3)24(32-4)12-20(19)26(28)30)25(29)27-13-18-9-6-16(2)10-22(18)33-15-17-7-8-17/h6,9-12,14,17H,5,7-8,13,15H2,1-4H3,(H,27,29)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363764
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCCC(C)(C)C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C20H28N2O4/c1-7-22-12-15(18(23)21-9-8-20(2,3)4)13-10-16(25-5)17(26-6)11-14(13)19(22)24/h10-12H,7-9H2,1-6H3,(H,21,23)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363771
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2ccc(F)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H21FN2O4/c1-4-24-12-17(20(25)23-11-13-5-7-14(22)8-6-13)15-9-18(27-2)19(28-3)10-16(15)21(24)26/h5-10,12H,4,11H2,1-3H3,(H,23,25)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363773
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2ccc(F)cc2F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H20F2N2O4/c1-4-25-11-16(20(26)24-10-12-5-6-13(22)7-17(12)23)14-8-18(28-2)19(29-3)9-15(14)21(25)27/h5-9,11H,4,10H2,1-3H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363824
PNG
(2-Isopropyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoqui...)
Show SMILES COc1cc2c(cn(C(C)C)c(=O)c2cc1OC)C(=O)NC1CCc2ccccc12
Show InChI InChI=1/C24H26N2O4/c1-14(2)26-13-19(17-11-21(29-3)22(30-4)12-18(17)24(26)28)23(27)25-20-10-9-15-7-5-6-8-16(15)20/h5-8,11-14,20H,9-10H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363803
PNG
(2-Ethyl-6,7-dimethoxy-N-(2-(morpholinomethyl)benzy...)
Show SMILES CCn1cc(C(=O)NCc2ccccc2CN2CCOCC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C26H31N3O5/c1-4-29-17-22(20-13-23(32-2)24(33-3)14-21(20)26(29)31)25(30)27-15-18-7-5-6-8-19(18)16-28-9-11-34-12-10-28/h5-8,13-14,17H,4,9-12,15-16H2,1-3H3,(H,27,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363811
PNG
(2-Ethyl-N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-6,7...)
Show SMILES CCn1cc(C(=O)NC2CCc3cc(F)ccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C23H23FN2O4/c1-4-26-12-18(16-10-20(29-2)21(30-3)11-17(16)23(26)28)22(27)25-19-8-5-13-9-14(24)6-7-15(13)19/h6-7,9-12,19H,4-5,8H2,1-3H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363863
PNG
(N-(4-Chloro-2,3-dihydro-1H-inden-1-yl)-6,7-dimetho...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3c2cccc3Cl)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C26H29ClN2O4/c1-5-15(6-2)29-14-20(18-12-23(32-3)24(33-4)13-19(18)26(29)31)25(30)28-22-11-10-16-17(22)8-7-9-21(16)27/h7-9,12-15,22H,5-6,10-11H2,1-4H3,(H,28,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363870
PNG
(N-[[2-(1,1-Dimethylpropoxy)-4-methyl-phenyl]methyl...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OC(C)(C)CC)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C27H34N2O5/c1-8-27(4,5)34-22-12-17(3)10-11-18(22)15-28-25(30)21-16-29(9-2)26(31)20-14-24(33-7)23(32-6)13-19(20)21/h10-14,16H,8-9,15H2,1-7H3,(H,28,30)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363883
PNG
(2-Ethyl-N-[(4-ethylphenyl)methyl]-6,7-dimethoxy-1-...)
Show SMILES CCc1ccc(CNC(=O)c2cn(CC)c(=O)c3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C23H26N2O4/c1-5-15-7-9-16(10-8-15)13-24-22(26)19-14-25(6-2)23(27)18-12-21(29-4)20(28-3)11-17(18)19/h7-12,14H,5-6,13H2,1-4H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363784
PNG
(2-Ethyl-6,7-dimethoxy-4-((2-methoxybenzylamino)car...)
Show SMILES CCn1cc(C(=O)NCc2ccccc2OC)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H24N2O5/c1-5-24-13-17(21(25)23-12-14-8-6-7-9-18(14)27-2)15-10-19(28-3)20(29-4)11-16(15)22(24)26/h6-11,13H,5,12H2,1-4H3,(H,23,25)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363818
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)N[C@@H]2CCc3ccccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C26H30N2O4/c1-5-17(6-2)28-15-21(19-13-23(31-3)24(32-4)14-20(19)26(28)30)25(29)27-22-12-11-16-9-7-8-10-18(16)22/h7-10,13-15,17,22H,5-6,11-12H2,1-4H3,(H,27,29)/t22-/m1/s1
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363826
PNG
((-)-2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dih...)
Show SMILES CCC(CC)n1cc(C(=O)NC2CCc3ncccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C25H29N3O4/c1-5-15(6-2)28-14-19(17-12-22(31-3)23(32-4)13-18(17)25(28)30)24(29)27-21-10-9-20-16(21)8-7-11-26-20/h7-8,11-15,21H,5-6,9-10H2,1-4H3,(H,27,29)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363827
PNG
(2-(1-Ethyl-propyl)-6,7-dimethoxy-1-oxo-1,2-dihydro...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2nncs2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C20H24N4O4S/c1-5-12(6-2)24-10-15(19(25)21-9-18-23-22-11-29-18)13-7-16(27-3)17(28-4)8-14(13)20(24)26/h7-8,10-12H,5-6,9H2,1-4H3,(H,21,25)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363788
PNG
(2-Ethyl-6,7-dimethoxy-N-(2-methoxyphenyl)-1-oxo-1,...)
Show SMILES CCn1cc(C(=O)Nc2ccccc2OC)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H22N2O5/c1-5-23-12-15(20(24)22-16-8-6-7-9-17(16)26-2)13-10-18(27-3)19(28-4)11-14(13)21(23)25/h6-12H,5H2,1-4H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363799
PNG
(N-(2-Chlorobenzyl)-2-ethyl-6,7-dimethoxy-1-oxo-1,2...)
Show SMILES CCn1cc(C(=O)NCc2ccccc2Cl)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H21ClN2O4/c1-4-24-12-16(20(25)23-11-13-7-5-6-8-17(13)22)14-9-18(27-2)19(28-3)10-15(14)21(24)26/h5-10,12H,4,11H2,1-3H3,(H,23,25)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363805
PNG
(2-Ethyl-N-(6-fluoro-2,3-dihydro-1H-inden-1-yl)-6,7...)
Show SMILES CCn1cc(C(=O)NC2CCc3ccc(F)cc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C23H23FN2O4/c1-4-26-12-18(16-10-20(29-2)21(30-3)11-17(16)23(26)28)22(27)25-19-8-6-13-5-7-14(24)9-15(13)19/h5,7,9-12,19H,4,6,8H2,1-3H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363868
PNG
(2-Ethyl-N-[(2-fluoro-4-methyl-phenyl)methyl]-6,7-d...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H23FN2O4/c1-5-25-12-17(21(26)24-11-14-7-6-13(2)8-18(14)23)15-9-19(28-3)20(29-4)10-16(15)22(25)27/h6-10,12H,5,11H2,1-4H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363882
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-[(1S)-1-(p-tolyl)eth...)
Show SMILES CCn1cc(C(=O)N[C@@H](C)c2ccc(C)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H26N2O4/c1-6-25-13-19(22(26)24-15(3)16-9-7-14(2)8-10-16)17-11-20(28-4)21(29-5)12-18(17)23(25)27/h7-13,15H,6H2,1-5H3,(H,24,26)/t15-/m0/s1
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363887
PNG
(N-[(4-Cyclopropylphenyl)methyl]-2-ethyl-6,7-dimeth...)
Show SMILES CCn1cc(C(=O)NCc2ccc(cc2)C2CC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H26N2O4/c1-4-26-14-20(18-11-21(29-2)22(30-3)12-19(18)24(26)28)23(27)25-13-15-5-7-16(8-6-15)17-9-10-17/h5-8,11-12,14,17H,4,9-10,13H2,1-3H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363759
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCCC(C)NC(=O)c1cn(CC)c(=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1/C19H26N2O4/c1-6-8-12(3)20-18(22)15-11-21(7-2)19(23)14-10-17(25-5)16(24-4)9-13(14)15/h9-12H,6-8H2,1-5H3,(H,20,22)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363760
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCC(C)CNC(=O)c1cn(CC)c(=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1/C19H26N2O4/c1-6-12(3)10-20-18(22)15-11-21(7-2)19(23)14-9-17(25-5)16(24-4)8-13(14)15/h8-9,11-12H,6-7,10H2,1-5H3,(H,20,22)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363783
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-(pyrimidin-4-ylmethy...)
Show SMILES CCn1cc(C(=O)NCc2ccncn2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C19H20N4O4/c1-4-23-10-15(18(24)21-9-12-5-6-20-11-22-12)13-7-16(26-2)17(27-3)8-14(13)19(23)25/h5-8,10-11H,4,9H2,1-3H3,(H,21,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363829
PNG
((-)-2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoqui...)
Show SMILES CCn1cc(C(=O)NC2CCc3sccc23)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C21H22N2O4S/c1-4-23-11-15(20(24)22-16-5-6-19-12(16)7-8-28-19)13-9-17(26-2)18(27-3)10-14(13)21(23)25/h7-11,16H,4-6H2,1-3H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363847
PNG
(6,7-Dimethoxy-N-((4-methylthiazol-5-yl)methyl)-1-o...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2scnc2C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H27N3O4S/c1-6-14(7-2)25-11-17(21(26)23-10-20-13(3)24-12-30-20)15-8-18(28-4)19(29-5)9-16(15)22(25)27/h8-9,11-12,14H,6-7,10H2,1-5H3,(H,23,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363843
PNG
(6,7-Dimethoxy-N-((5-methylisoxazol-3-yl)methyl)-1-...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2cc(C)on2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H27N3O5/c1-6-15(7-2)25-12-18(21(26)23-11-14-8-13(3)30-24-14)16-9-19(28-4)20(29-5)10-17(16)22(25)27/h8-10,12,15H,6-7,11H2,1-5H3,(H,23,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363790
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-(pyridin-3-ylmethyl)...)
Show SMILES CCn1cc(C(=O)NCc2cccnc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C20H21N3O4/c1-4-23-12-16(19(24)22-11-13-6-5-7-21-10-13)14-8-17(26-2)18(27-3)9-15(14)20(23)25/h5-10,12H,4,11H2,1-3H3,(H,22,24)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363859
PNG
(6,7-Dimethoxy-1-oxo-2-(pentan-3-yl)-N-(pyridin-4-y...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccncc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H27N3O4/c1-5-16(6-2)26-14-19(22(27)25-13-15-7-9-24-10-8-15)17-11-20(29-3)21(30-4)12-18(17)23(26)28/h7-12,14,16H,5-6,13H2,1-4H3,(H,25,27)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363866
PNG
(6,7-Dimethoxy-N-((2-methylfuran-3-yl)methyl)-1-oxo...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2ccoc2C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H28N2O5/c1-6-16(7-2)25-13-19(22(26)24-12-15-8-9-30-14(15)3)17-10-20(28-4)21(29-5)11-18(17)23(25)27/h8-11,13,16H,6-7,12H2,1-5H3,(H,24,26)
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363877
PNG
(2-Ethyl-6,7-dimethoxy-N-(4-methyl-2-(tetrahydrofur...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OC2CCOC2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C26H30N2O6/c1-5-28-14-21(19-11-23(31-3)24(32-4)12-20(19)26(28)30)25(29)27-13-17-7-6-16(2)10-22(17)34-18-8-9-33-15-18/h6-7,10-12,14,18H,5,8-9,13,15H2,1-4H3,(H,27,29)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363880
PNG
(2-Ethyl-6,7-dimethoxy-N-(2-methoxy-4-methylbenzyl)...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OC)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C23H26N2O5/c1-6-25-13-18(16-10-20(29-4)21(30-5)11-17(16)23(25)27)22(26)24-12-15-8-7-14(2)9-19(15)28-3/h7-11,13H,6,12H2,1-5H3,(H,24,26)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363767
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NC(C)c2ccccc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C22H24N2O4/c1-5-24-13-18(21(25)23-14(2)15-9-7-6-8-10-15)16-11-19(27-3)20(28-4)12-17(16)22(24)26/h6-14H,5H2,1-4H3,(H,23,25)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363768
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2ccccc2F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H21FN2O4/c1-4-24-12-16(20(25)23-11-13-7-5-6-8-17(13)22)14-9-18(27-2)19(28-3)10-15(14)21(24)26/h5-10,12H,4,11H2,1-3H3,(H,23,25)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363770
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2cccc(F)c2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H21FN2O4/c1-4-24-12-17(20(25)23-11-13-6-5-7-14(22)8-13)15-9-18(27-2)19(28-3)10-16(15)21(24)26/h5-10,12H,4,11H2,1-3H3,(H,23,25)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363772
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoli...)
Show SMILES CCn1cc(C(=O)NCc2cccc(F)c2F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H20F2N2O4/c1-4-25-11-15(20(26)24-10-12-6-5-7-16(22)19(12)23)13-8-17(28-2)18(29-3)9-14(13)21(25)27/h5-9,11H,4,10H2,1-3H3,(H,24,26)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363779
PNG
(4-(1,3-Dihydro-isoindole-2-carbonyl)-2-ethyl-6,7-d...)
Show SMILES CCn1cc(C(=O)N2Cc3ccccc3C2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H22N2O4/c1-4-23-13-18(22(26)24-11-14-7-5-6-8-15(14)12-24)16-9-19(27-2)20(28-3)10-17(16)21(23)25/h5-10,13H,4,11-12H2,1-3H3
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AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363842
PNG
(N-((2,5-dimethylthiophen-3-yl)methyl)-6,7-dimethox...)
Show SMILES CCC(CC)n1cc(C(=O)NCc2cc(C)sc2C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C24H30N2O4S/c1-7-17(8-2)26-13-20(23(27)25-12-16-9-14(3)31-15(16)4)18-10-21(29-5)22(30-6)11-19(18)24(26)28/h9-11,13,17H,7-8,12H2,1-6H3,(H,25,27)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363791
PNG
(2-Ethyl-6,7-dimethoxy-1-oxo-N-(pyridin-2-ylmethyl)...)
Show SMILES CCn1cc(C(=O)NCc2ccccn2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C20H21N3O4/c1-4-23-12-16(19(24)22-11-13-7-5-6-8-21-13)14-9-17(26-2)18(27-3)10-15(14)20(23)25/h5-10,12H,4,11H2,1-3H3,(H,22,24)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363793
PNG
(2-Ethyl-6,7-dimethoxy-N-(4-methoxybenzyl)-1-oxo-1,...)
Show SMILES CCn1cc(C(=O)NCc2ccc(OC)cc2)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C22H24N2O5/c1-5-24-13-18(21(25)23-12-14-6-8-15(27-2)9-7-14)16-10-19(28-3)20(29-4)11-17(16)22(24)26/h6-11,13H,5,12H2,1-4H3,(H,23,25)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363807
PNG
(2-Ethyl-N-(4-fluoro-2,3-dihydro-1H-inden-1-yl)-6,7...)
Show SMILES CCn1cc(C(=O)NC2CCc3c2cccc3F)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1/C23H23FN2O4/c1-4-26-12-17(15-10-20(29-2)21(30-3)11-16(15)23(26)28)22(27)25-19-9-8-13-14(19)6-5-7-18(13)24/h5-7,10-12,19H,4,8-9H2,1-3H3,(H,25,27)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM363869
PNG
(N-[(2-tert-Butoxy-4-methyl-phenyl)methyl]-2-ethyl-...)
Show SMILES CCn1cc(C(=O)NCc2ccc(C)cc2OC(C)(C)C)c2cc(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C26H32N2O5/c1-8-28-15-20(18-12-22(31-6)23(32-7)13-19(18)25(28)30)24(29)27-14-17-10-9-16(2)11-21(17)33-26(3,4)5/h9-13,15H,8,14H2,1-7H3,(H,27,29)
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n/an/a 350n/an/an/an/an/an/a



AbbVie Deutschland GmbH & Co. KG; AbbVie Inc.

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9856220 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%