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Patent code US9856250

Compile Data Set for Download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363976
PNG
(N-[(exo)-8-(tert-Butylcarbamoyl)methyl-8-azabicycl...)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1coc3ccccc13)C2
Show InChI InChI=1/C23H31N3O3/c1-23(2,3)25-21(27)13-26-16-8-9-17(26)11-15(10-16)12-24-22(28)19-14-29-20-7-5-4-6-18(19)20/h4-7,14-17H,8-13H2,1-3H3,(H,24,28)(H,25,27)/t15-,16-,17+
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US Patent
n/an/a 3n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364007
PNG
(US9856250, 84)
Show SMILES CCC1=C(C2C=CC=CC2O1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C25H37N3O3/c1-5-20-23(19-8-6-7-9-21(19)31-20)24(30)26-14-16-12-17-10-11-18(13-16)28(17)15-22(29)27-25(2,3)4/h6-9,16-19,21H,5,10-15H2,1-4H3,(H,26,30)(H,27,29)/t16-,17-,18+,19?,21?
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US Patent
n/an/a 10n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364014
PNG
(3-Chloro-5-fluoro-N-{(exo)-8-[(2-methoxy-1,1-dimet...)
Show SMILES COCC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cc(F)cc(Cl)c1)C2
Show InChI InChI=1/C22H31ClFN3O3/c1-22(2,13-30-3)26-20(28)12-27-18-4-5-19(27)7-14(6-18)11-25-21(29)15-8-16(23)10-17(24)9-15/h8-10,14,18-19H,4-7,11-13H2,1-3H3,(H,25,29)(H,26,28)/t14-,18-,19+
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US Patent
n/an/a 13n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364008
PNG
(US9856250, 85)
Show SMILES CC1=C(C2C=CC=CC2O1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C24H35N3O3/c1-15-22(19-7-5-6-8-20(19)30-15)23(29)25-13-16-11-17-9-10-18(12-16)27(17)14-21(28)26-24(2,3)4/h5-8,16-20H,9-14H2,1-4H3,(H,25,29)(H,26,28)/t16-,17-,18+,19?,20?
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n/an/a 15n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363992
PNG
(US9856250, 54)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cc(O)cc(Cl)c1)C2
Show InChI InChI=1/C21H30ClN3O3/c1-21(2,3)24-19(27)12-25-16-4-5-17(25)7-13(6-16)11-23-20(28)14-8-15(22)10-18(26)9-14/h8-10,13,16-17,26H,4-7,11-12H2,1-3H3,(H,23,28)(H,24,27)/t13-,16-,17+
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US Patent
n/an/a 20n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364003
PNG
(US9856250, 77)
Show SMILES Cc1ccc(cc1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C22H33N3O2/c1-15-5-7-17(8-6-15)21(27)23-13-16-11-18-9-10-19(12-16)25(18)14-20(26)24-22(2,3)4/h5-8,16,18-19H,9-14H2,1-4H3,(H,23,27)(H,24,26)/t16-,18-,19+
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US Patent
n/an/a 22n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363994
PNG
(US9856250, 56)
Show SMILES CCc1cc(F)cc(c1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C23H34FN3O2/c1-5-15-8-17(12-18(24)9-15)22(29)25-13-16-10-19-6-7-20(11-16)27(19)14-21(28)26-23(2,3)4/h8-9,12,16,19-20H,5-7,10-11,13-14H2,1-4H3,(H,25,29)(H,26,28)/t16-,19-,20+
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US Patent
n/an/a 34n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363993
PNG
(US9856250, 55)
Show SMILES Cc1cc(F)cc(c1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C22H32FN3O2/c1-14-7-16(11-17(23)8-14)21(28)24-12-15-9-18-5-6-19(10-15)26(18)13-20(27)25-22(2,3)4/h7-8,11,15,18-19H,5-6,9-10,12-13H2,1-4H3,(H,24,28)(H,25,27)/t15-,18-,19+
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US Patent
n/an/a 36n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364020
PNG
(US9856250, 113)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cc(F)cc(Cl)c1)C2
Show InChI InChI=1/C21H29ClFN3O2/c1-21(2,3)25-19(27)12-26-17-4-5-18(26)7-13(6-17)11-24-20(28)14-8-15(22)10-16(23)9-14/h8-10,13,17-18H,4-7,11-12H2,1-3H3,(H,24,28)(H,25,27)/t13-,17-,18+
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US Patent
n/an/a 39n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363998
PNG
(US9856250, 67)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)C1C(C)(C)C1(C)C)C2
Show InChI InChI=1/C22H39N3O2/c1-20(2,3)24-17(26)13-25-15-8-9-16(25)11-14(10-15)12-23-19(27)18-21(4,5)22(18,6)7/h14-16,18H,8-13H2,1-7H3,(H,23,27)(H,24,26)/t14-,15-,16+
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US Patent
n/an/a 42n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364104
PNG
(N-[(endo)-8-(tert-Butylcarbamoyl)methyl-8-azabicyc...)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@H](CNC(=O)C13CC4CC(CC(C4)C1)C3)C2
Show InChI InChI=1/C25H41N3O2/c1-24(2,3)27-22(29)15-28-20-4-5-21(28)10-19(9-20)14-26-23(30)25-11-16-6-17(12-25)8-18(7-16)13-25/h16-21H,4-15H2,1-3H3,(H,26,30)(H,27,29)/t16?,17?,18?,19-,20+,21-,25?
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US Patent
n/an/a 44n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364004
PNG
(US9856250, 78)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1ccc(F)cc1)C2
Show InChI InChI=1/C21H30FN3O2/c1-21(2,3)24-19(26)13-25-17-8-9-18(25)11-14(10-17)12-23-20(27)15-4-6-16(22)7-5-15/h4-7,14,17-18H,8-13H2,1-3H3,(H,23,27)(H,24,26)/t14-,17-,18+
UniProtKB/SwissProt

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US Patent
n/an/a 44n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364005
PNG
(US9856250, 79)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cc(F)cc(c1)C#C)C2
Show InChI InChI=1/C23H30FN3O2/c1-5-15-8-17(12-18(24)9-15)22(29)25-13-16-10-19-6-7-20(11-16)27(19)14-21(28)26-23(2,3)4/h1,8-9,12,16,19-20H,6-7,10-11,13-14H2,2-4H3,(H,25,29)(H,26,28)/t16-,19-,20+
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US Patent
n/an/a 45n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363977
PNG
(US9856250, 16)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1csc3CCCCc13)C2
Show InChI InChI=1/C23H35N3O2S/c1-23(2,3)25-21(27)13-26-16-8-9-17(26)11-15(10-16)12-24-22(28)19-14-29-20-7-5-4-6-18(19)20/h14-17H,4-13H2,1-3H3,(H,24,28)(H,25,27)/t15-,16-,17+
UniProtKB/SwissProt

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US Patent
n/an/a 47n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363990
PNG
(US9856250, 52)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cccc(Cl)c1)C2
Show InChI InChI=1/C21H30ClN3O2/c1-21(2,3)24-19(26)13-25-17-7-8-18(25)10-14(9-17)12-23-20(27)15-5-4-6-16(22)11-15/h4-6,11,14,17-18H,7-10,12-13H2,1-3H3,(H,23,27)(H,24,26)/t14-,17-,18+
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US Patent
n/an/a 48n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363979
PNG
(US9856250, 19)
Show SMILES Cc1oc2CCCCc2c1NC(=O)C[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C24H37N3O3/c1-15-23(19-7-5-6-8-20(19)30-15)25-21(28)13-16-11-17-9-10-18(12-16)27(17)14-22(29)26-24(2,3)4/h16-18H,5-14H2,1-4H3,(H,25,28)(H,26,29)/t16-,17-,18+
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US Patent
n/an/a 48n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363991
PNG
(US9856250, 53)
Show SMILES COc1cc(Cl)cc(c1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C22H32ClN3O3/c1-22(2,3)25-20(27)13-26-17-5-6-18(26)8-14(7-17)12-24-21(28)15-9-16(23)11-19(10-15)29-4/h9-11,14,17-18H,5-8,12-13H2,1-4H3,(H,24,28)(H,25,27)/t14-,17-,18+
UniProtKB/SwissProt

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US Patent
n/an/a 49n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364108
PNG
(US9856250, 160)
Show SMILES Cn1nc(cc1C(=O)NC[C@@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C)C1CC1
Show InChI InChI=1/C22H35N5O2/c1-22(2,3)24-20(28)13-27-16-7-8-17(27)10-14(9-16)12-23-21(29)19-11-18(15-5-6-15)25-26(19)4/h11,14-17H,5-10,12-13H2,1-4H3,(H,23,29)(H,24,28)/t14-,16+,17-
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n/an/a 49n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364103
PNG
(US9856250, 131)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@H](CC(=O)NC13CC4CC1CC(C3)C4)C2
Show InChI InChI=1/C24H39N3O2/c1-23(2,3)25-22(29)14-27-19-4-5-20(27)10-15(9-19)11-21(28)26-24-12-16-6-17(13-24)8-18(24)7-16/h15-20H,4-14H2,1-3H3,(H,25,29)(H,26,28)/t15-,16?,17?,18?,19+,20-,24?
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US Patent
n/an/a 49n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363987
PNG
(US9856250, 36)
Show SMILES CCN1C=C(C2C=CC=CC12)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C25H38N4O2/c1-5-28-15-21(20-8-6-7-9-22(20)28)24(31)26-14-17-12-18-10-11-19(13-17)29(18)16-23(30)27-25(2,3)4/h6-9,15,17-20,22H,5,10-14,16H2,1-4H3,(H,26,31)(H,27,30)/t17-,18-,19+,20?,22?
UniProtKB/SwissProt

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US Patent
n/an/a 49n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364015
PNG
(US9856250, 107)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=C)C13CC4CC(CC(C4)C1)C3)C2
Show InChI InChI=1/C26H43N3O/c1-17(26-12-18-7-19(13-26)9-20(8-18)14-26)27-15-21-10-22-5-6-23(11-21)29(22)16-24(30)28-25(2,3)4/h18-23,27H,1,5-16H2,2-4H3,(H,28,30)/t18?,19?,20?,21-,22-,23+,26?
UniProtKB/SwissProt

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US Patent
n/an/a 49n/an/an/an/an/an/a



TOA EIYO LTD.

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363999
PNG
(US9856250, 69)
Show SMILES Cn1nc(cc1C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C)C(C)(C)C
Show InChI InChI=1/C23H39N5O2/c1-22(2,3)19-12-18(27(7)26-19)21(30)24-13-15-10-16-8-9-17(11-15)28(16)14-20(29)25-23(4,5)6/h12,15-17H,8-11,13-14H2,1-7H3,(H,24,30)(H,25,29)/t15-,16-,17+
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n/an/a 51n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364001
PNG
(US9856250, 72)
Show SMILES COc1cc(C)cc(c1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C23H35N3O3/c1-15-8-17(12-20(9-15)29-5)22(28)24-13-16-10-18-6-7-19(11-16)26(18)14-21(27)25-23(2,3)4/h8-9,12,16,18-19H,6-7,10-11,13-14H2,1-5H3,(H,24,28)(H,25,27)/t16-,18-,19+
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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364011
PNG
(US9856250, 96)
Show SMILES COc1cc(C)cc(c1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC1(CC1)C(F)(F)F
Show InChI InChI=1/C23H30F3N3O3/c1-14-7-16(11-19(8-14)32-2)21(31)27-12-15-9-17-3-4-18(10-15)29(17)13-20(30)28-22(5-6-22)23(24,25)26/h7-8,11,15,17-18H,3-6,9-10,12-13H2,1-2H3,(H,27,31)(H,28,30)/t15-,17-,18+
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n/an/a 58n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364042
PNG
(N-tert-Butyl-2- [(exo)-3-(4-methyl-1H-benzimidazol...)
Show SMILES Cc1cccc2[nH]c(C[C@H]3C[C@@H]4CC[C@H](C3)N4CC(=O)NC(C)(C)C)nc12
Show InChI InChI=1/C22H32N4O/c1-14-6-5-7-18-21(14)24-19(23-18)12-15-10-16-8-9-17(11-15)26(16)13-20(27)25-22(2,3)4/h5-7,15-17H,8-13H2,1-4H3,(H,23,24)(H,25,27)/t15-,16-,17+
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n/an/a 59n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363995
PNG
(US9856250, 59)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1ccc3OCCCc3c1)C2
Show InChI InChI=1/C24H35N3O3/c1-24(2,3)26-22(28)15-27-19-7-8-20(27)12-16(11-19)14-25-23(29)18-6-9-21-17(13-18)5-4-10-30-21/h6,9,13,16,19-20H,4-5,7-8,10-12,14-15H2,1-3H3,(H,25,29)(H,26,28)/t16-,19-,20+
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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364027
PNG
(US9856250, 115)
Show SMILES CC1(CC1)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cc(F)cc(Cl)c1)C2
Show InChI InChI=1/C21H27ClFN3O2/c1-21(4-5-21)25-19(27)12-26-17-2-3-18(26)7-13(6-17)11-24-20(28)14-8-15(22)10-16(23)9-14/h8-10,13,17-18H,2-7,11-12H2,1H3,(H,24,28)(H,25,27)/t13-,17-,18+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364000
PNG
(US9856250, 71)
Show SMILES CC(C)(C)CCC(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C21H39N3O2/c1-20(2,3)10-9-18(25)22-13-15-11-16-7-8-17(12-15)24(16)14-19(26)23-21(4,5)6/h15-17H,7-14H2,1-6H3,(H,22,25)(H,23,26)/t15-,16-,17+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363983
PNG
(US9856250, 28)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)C(C)(C)Oc1ccccc1)C2
Show InChI InChI=1/C24H37N3O3/c1-23(2,3)26-21(28)16-27-18-11-12-19(27)14-17(13-18)15-25-22(29)24(4,5)30-20-9-7-6-8-10-20/h6-10,17-19H,11-16H2,1-5H3,(H,25,29)(H,26,28)/t17-,18-,19+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364102
PNG
(N-(Adamantan-1-yl)-2-[(endo)-8-(tert-butylcarbamoy...)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@H](CC(=O)NC13CC4CC(CC(C4)C1)C3)C2
Show InChI InChI=1/C25H41N3O2/c1-24(2,3)26-23(30)15-28-20-4-5-21(28)10-16(9-20)11-22(29)27-25-12-17-6-18(13-25)8-19(7-17)14-25/h16-21H,4-15H2,1-3H3,(H,26,30)(H,27,29)/t16-,17?,18?,19?,20+,21-,25?
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363988
PNG
(US9856250, 37)
Show SMILES CN1C2C=CC=CC2C(C(=O)NC[C@H]2C[C@@H]3CC[C@H](C2)N3CC(=O)NC(C)(C)C)=C1C
Show InChI InChI=1/C25H38N4O2/c1-16-23(20-8-6-7-9-21(20)28(16)5)24(31)26-14-17-12-18-10-11-19(13-17)29(18)15-22(30)27-25(2,3)4/h6-9,17-21H,10-15H2,1-5H3,(H,26,31)(H,27,30)/t17-,18-,19+,20?,21?
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363897
PNG
(2-[(exo)-8-(tert-Butylcarbamoyl)methyl-8-azabicycl...)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CC(=O)Nc1cccc(Cl)c1)C2
Show InChI InChI=1/C21H30ClN3O2/c1-21(2,3)24-20(27)13-25-17-7-8-18(25)10-14(9-17)11-19(26)23-16-6-4-5-15(22)12-16/h4-6,12,14,17-18H,7-11,13H2,1-3H3,(H,23,26)(H,24,27)/t14-,17-,18+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363933
PNG
(US9856250, 3)
Show SMILES COc1cc(F)cc(NC(=O)C[C@H]2C[C@@H]3CC[C@H](C2)N3CC(=O)NC(C)(C)C)c1
Show InChI InChI=1/C22H32FN3O3/c1-22(2,3)25-21(28)13-26-17-5-6-18(26)8-14(7-17)9-20(27)24-16-10-15(23)11-19(12-16)29-4/h10-12,14,17-18H,5-9,13H2,1-4H3,(H,24,27)(H,25,28)/t14-,17-,18+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364021
PNG
(US9856250, 114)
Show SMILES Fc1cc(Cl)cc(c1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC1(CC1)C(F)(F)F
Show InChI InChI=1/C21H24ClF4N3O2/c22-14-7-13(8-15(23)9-14)19(31)27-10-12-5-16-1-2-17(6-12)29(16)11-18(30)28-20(3-4-20)21(24,25)26/h7-9,12,16-17H,1-6,10-11H2,(H,27,31)(H,28,30)/t12-,16-,17+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363984
PNG
(US9856250, 31)
Show SMILES Cc1cc(on1)C1(CCCCC1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C25H40N4O3/c1-17-12-21(32-28-17)25(10-6-5-7-11-25)23(31)26-15-18-13-19-8-9-20(14-18)29(19)16-22(30)27-24(2,3)4/h12,18-20H,5-11,13-16H2,1-4H3,(H,26,31)(H,27,30)/t18-,19-,20+
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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363934
PNG
(N-(Adamantan-1-yl)-2-[(exo)-8-(tert-butylcarbamoyl...)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CC(=O)NC13CC4CC(CC(C4)C1)C3)C2
Show InChI InChI=1/C25H41N3O2/c1-24(2,3)26-23(30)15-28-20-4-5-21(28)10-16(9-20)11-22(29)27-25-12-17-6-18(13-25)8-19(7-17)14-25/h16-21H,4-15H2,1-3H3,(H,26,30)(H,27,29)/t16-,17?,18?,19?,20-,21+,25?
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364101
PNG
(2-[(endo)-8-(tert-Butylcarbamoyl)methyl-8-azabicyc...)
Show SMILES CC(C)(C)CNC(=O)C[C@@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C20H37N3O2/c1-19(2,3)13-21-17(24)11-14-9-15-7-8-16(10-14)23(15)12-18(25)22-20(4,5)6/h14-16H,7-13H2,1-6H3,(H,21,24)(H,22,25)/t14-,15+,16-
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363981
PNG
(US9856250, 24)
Show SMILES CN1C=C(C2C=CC=CC12)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C24H36N4O2/c1-24(2,3)26-22(29)15-28-17-9-10-18(28)12-16(11-17)13-25-23(30)20-14-27(4)21-8-6-5-7-19(20)21/h5-8,14,16-19,21H,9-13,15H2,1-4H3,(H,25,30)(H,26,29)/t16-,17-,18+,19?,21?
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363996
PNG
(US9856250, 60)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cccc3CCCc13)C2
Show InChI InChI=1/C24H35N3O2/c1-24(2,3)26-22(28)15-27-18-10-11-19(27)13-16(12-18)14-25-23(29)21-9-5-7-17-6-4-8-20(17)21/h5,7,9,16,18-19H,4,6,8,10-15H2,1-3H3,(H,25,29)(H,26,28)/t16-,18-,19+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364107
PNG
(US9856250, 154)
Show SMILES COc1cc(F)c2nc(C[C@@H]3C[C@@H]4CC[C@H](C3)N4CC(=O)NC(C)(C)C)[nH]c2c1
Show InChI InChI=1/C22H31FN4O2/c1-22(2,3)26-20(28)12-27-14-5-6-15(27)8-13(7-14)9-19-24-18-11-16(29-4)10-17(23)21(18)25-19/h10-11,13-15H,5-9,12H2,1-4H3,(H,24,25)(H,26,28)/t13-,14+,15-
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364030
PNG
(US9856250, 118)
Show SMILES CN(C(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cc(F)cc(Cl)c1)C2)C(C)(C)C
Show InChI InChI=1/C22H31ClFN3O2/c1-22(2,3)26(4)20(28)13-27-18-5-6-19(27)8-14(7-18)12-25-21(29)15-9-16(23)11-17(24)10-15/h9-11,14,18-19H,5-8,12-13H2,1-4H3,(H,25,29)/t14-,18-,19+
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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363934
PNG
(N-(Adamantan-1-yl)-2-[(exo)-8-(tert-butylcarbamoyl...)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CC(=O)NC13CC4CC(CC(C4)C1)C3)C2
Show InChI InChI=1/C25H41N3O2/c1-24(2,3)26-23(30)15-28-20-4-5-21(28)10-16(9-20)11-22(29)27-25-12-17-6-18(13-25)8-19(7-17)14-25/h16-21H,4-15H2,1-3H3,(H,26,30)(H,27,29)/t16-,17?,18?,19?,20-,21+,25?
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n/an/a 82n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364106
PNG
(US9856250, 147)
Show SMILES Cc1cccc2[nH]c(C[C@@H]3C[C@@H]4CC[C@H](C3)N4CC(=O)NC(C)(C)C)nc12
Show InChI InChI=1/C22H32N4O/c1-14-6-5-7-18-21(14)24-19(23-18)12-15-10-16-8-9-17(11-15)26(16)13-20(27)25-22(2,3)4/h5-7,15-17H,8-13H2,1-4H3,(H,23,24)(H,25,27)/t15-,16+,17-
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n/an/a 83n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364012
PNG
(N-[(exo)-8-(tert-Butylcarbamoyl)methyl-8-azabicycl...)
Show SMILES Cn1cc(C(=O)NC[C@H]2C[C@@H]3CC[C@H](C2)N3CC(=O)NC(C)(C)C)c2cc(Cl)ccc12
Show InChI InChI=1/C24H33ClN4O2/c1-24(2,3)27-22(30)14-29-17-6-7-18(29)10-15(9-17)12-26-23(31)20-13-28(4)21-8-5-16(25)11-19(20)21/h5,8,11,13,15,17-18H,6-7,9-10,12,14H2,1-4H3,(H,26,31)(H,27,30)/t15-,17-,18+
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n/an/a 85n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364010
PNG
(US9856250, 95)
Show SMILES CC1=C(C2CCCCC2O1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC1(CC1)C(F)(F)F
Show InChI InChI=1/C24H34F3N3O3/c1-14-21(18-4-2-3-5-19(18)33-14)22(32)28-12-15-10-16-6-7-17(11-15)30(16)13-20(31)29-23(8-9-23)24(25,26)27/h15-19H,2-13H2,1H3,(H,28,32)(H,29,31)/t15-,16-,17+,18?,19?
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n/an/a 88n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364009
PNG
(US9856250, 86)
Show SMILES COC1=CC2C(OC(C)=C2C(=O)NC[C@H]2C[C@@H]3CC[C@H](C2)N3CC(=O)NC(C)(C)C)C=C1
Show InChI InChI=1/C25H37N3O4/c1-15-23(20-12-19(31-5)8-9-21(20)32-15)24(30)26-13-16-10-17-6-7-18(11-16)28(17)14-22(29)27-25(2,3)4/h8-9,12,16-18,20-21H,6-7,10-11,13-14H2,1-5H3,(H,26,30)(H,27,29)/t16-,17-,18+,20?,21?
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n/an/a 91n/an/an/an/an/an/a



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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364019
PNG
(US9856250, 112)
Show SMILES CC1(COC1)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1cc(F)cc(Cl)c1)C2
Show InChI InChI=1/C21H27ClFN3O3/c1-21(11-29-12-21)25-19(27)10-26-17-2-3-18(26)5-13(4-17)9-24-20(28)14-6-15(22)8-16(23)7-14/h6-8,13,17-18H,2-5,9-12H2,1H3,(H,24,28)(H,25,27)/t13-,17-,18+
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n/an/a 93n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364006
PNG
(US9856250, 81)
Show SMILES Cc1ccc(s1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C20H31N3O2S/c1-13-5-8-17(26-13)19(25)21-11-14-9-15-6-7-16(10-14)23(15)12-18(24)22-20(2,3)4/h5,8,14-16H,6-7,9-12H2,1-4H3,(H,21,25)(H,22,24)/t14-,15-,16+
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n/an/a 93n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363982
PNG
(US9856250, 27)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)C(C)(C)Oc1ccc(cc1)C1CC1(Cl)Cl)C2
Show InChI InChI=1/C27H39Cl2N3O3/c1-25(2,3)31-23(33)16-32-19-8-9-20(32)13-17(12-19)15-30-24(34)26(4,5)35-21-10-6-18(7-11-21)22-14-27(22,28)29/h6-7,10-11,17,19-20,22H,8-9,12-16H2,1-5H3,(H,30,34)(H,31,33)/t17-,19-,20+,22?
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n/an/a 94n/an/an/an/an/an/a



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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364018
PNG
(US9856250, 109)
Show SMILES OCC1(CCCC1)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)C13CC4CC(CC(C4)C1)C3)C2
Show InChI InChI=1/C27H43N3O3/c31-17-27(5-1-2-6-27)29-24(32)16-30-22-3-4-23(30)11-21(10-22)15-28-25(33)26-12-18-7-19(13-26)9-20(8-18)14-26/h18-23,31H,1-17H2,(H,28,33)(H,29,32)/t18?,19?,20?,21-,22-,23+,26?
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n/an/a 94n/an/an/an/an/an/a



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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364099
PNG
(US9856250, 124)
Show SMILES COc1cccc2[nH]c(C[C@H]3C[C@@H]4CC[C@H](C3)N4CC(=O)NC(C)(C)C)nc12
Show InChI InChI=1/C22H32N4O2/c1-22(2,3)25-20(27)13-26-15-8-9-16(26)11-14(10-15)12-19-23-17-6-5-7-18(28-4)21(17)24-19/h5-7,14-16H,8-13H2,1-4H3,(H,23,24)(H,25,27)/t14-,15-,16+
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n/an/a 96n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364105
PNG
(N-tert-Butyl-2-[(endo)-3-(4-methoxy-1H-benzimidazo...)
Show SMILES COc1cccc2[nH]c(C[C@@H]3C[C@@H]4CC[C@H](C3)N4CC(=O)NC(C)(C)C)nc12
Show InChI InChI=1/C22H32N4O2/c1-22(2,3)25-20(27)13-26-15-8-9-16(26)11-14(10-15)12-19-23-17-6-5-7-18(28-4)21(17)24-19/h5-7,14-16H,8-13H2,1-4H3,(H,23,24)(H,25,27)/t14-,15+,16-
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n/an/a 98n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363985
PNG
(US9856250, 32)
Show SMILES COc1cccc(OC(C)(C)C(=O)NC[C@H]2C[C@@H]3CC[C@H](C2)N3CC(=O)NC(C)(C)C)c1
Show InChI InChI=1/C25H39N3O4/c1-24(2,3)27-22(29)16-28-18-10-11-19(28)13-17(12-18)15-26-23(30)25(4,5)32-21-9-7-8-20(14-21)31-6/h7-9,14,17-19H,10-13,15-16H2,1-6H3,(H,26,30)(H,27,29)/t17-,18-,19+
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n/an/a 98n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363997
PNG
(US9856250, 65)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)C13CC4CC(CC(C4)C1)C3)C2
Show InChI InChI=1/C25H41N3O2/c1-24(2,3)27-22(29)15-28-20-4-5-21(28)10-19(9-20)14-26-23(30)25-11-16-6-17(12-25)8-18(7-16)13-25/h16-21H,4-15H2,1-3H3,(H,26,30)(H,27,29)/t16?,17?,18?,19-,20-,21+,25?
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n/an/a 99n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364002
PNG
(US9856250, 74)
Show SMILES CC(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1/C16H29N3O2/c1-11(20)17-9-12-7-13-5-6-14(8-12)19(13)10-15(21)18-16(2,3)4/h12-14H,5-10H2,1-4H3,(H,17,20)(H,18,21)/t12-,13-,14+
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n/an/a 101n/an/an/an/an/an/a



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Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363989
PNG
(US9856250, 45)
Show SMILES CN1C=C(C2C=CC=CC12)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC1(CC1)C(F)(F)F
Show InChI InChI=1/C24H31F3N4O2/c1-30-13-19(18-4-2-3-5-20(18)30)22(33)28-12-15-10-16-6-7-17(11-15)31(16)14-21(32)29-23(8-9-23)24(25,26)27/h2-5,13,15-18,20H,6-12,14H2,1H3,(H,28,33)(H,29,32)/t15-,16-,17+,18?,20?
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n/an/a 103n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364047
PNG
(US9856250, 122)
Show SMILES COc1ccc2[nH]c(C[C@H]3C[C@@H]4CC[C@H](C3)N4CC(=O)NC(C)(C)C)nc2c1OC
Show InChI InChI=1/C23H34N4O3/c1-23(2,3)26-20(28)13-27-15-6-7-16(27)11-14(10-15)12-19-24-17-8-9-18(29-4)22(30-5)21(17)25-19/h8-9,14-16H,6-7,10-13H2,1-5H3,(H,24,25)(H,26,28)/t14-,15-,16+
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n/an/a 138n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363980
PNG
(US9856250, 23)
Show SMILES Cc1cc(C(=O)NC[C@H]2C[C@@H]3CC[C@H](C2)N3CC(=O)NC(C)(C)C)n(C)n1
Show InChI InChI=1/C20H33N5O2/c1-13-8-17(24(5)23-13)19(27)21-11-14-9-15-6-7-16(10-14)25(15)12-18(26)22-20(2,3)4/h8,14-16H,6-7,9-12H2,1-5H3,(H,21,27)(H,22,26)/t14-,15-,16+
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n/an/a 203n/an/an/an/an/an/a



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US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%