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Patent code US9856252

Compile Data Set for Download or QSAR
Found 107 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364153
PNG
(US9856252, 45)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)C1=CCNCC1)c1ccccc1
Show InChI InChI=1S/C24H22N4O/c1-2-4-17(5-3-1)16-29-20-8-6-19(7-9-20)23-27-22-11-10-21(26-24(22)28-23)18-12-14-25-15-13-18/h1-12,25H,13-16H2,(H,26,27,28)
PDB

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US Patent
n/an/a 83n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364124
PNG
(US9856252, 16)
Show SMILES C(Oc1ccccc1)c1ccc(cc1)-c1nc2cc(cnc2[nH]1)C1CCCNC1
Show InChI InChI=1/C24H24N4O/c1-2-6-21(7-3-1)29-16-17-8-10-18(11-9-17)23-27-22-13-20(15-26-24(22)28-23)19-5-4-12-25-14-19/h1-3,6-11,13,15,19,25H,4-5,12,14,16H2,(H,26,27,28)
PDB

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US Patent
n/an/a 107n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364120
PNG
(US9856252, 12)
Show SMILES C(Oc1ccc(cc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C24H24N4O/c1-2-4-17(5-3-1)16-29-21-8-6-19(7-9-21)23-27-22-14-20(15-26-24(22)28-23)18-10-12-25-13-11-18/h1-9,14-15,18,25H,10-13,16H2,(H,26,27,28)
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n/an/a 122n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364134
PNG
(US9856252, 26)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H25N5O/c1-28-13-15-29(16-14-28)22-12-11-21-24(26-22)27-23(25-21)19-7-9-20(10-8-19)30-17-18-5-3-2-4-6-18/h2-12H,13-17H2,1H3,(H,25,26,27)
PDB

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n/an/a 132n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364198
PNG
(US9856252, 90)
Show SMILES CCS(=O)(=O)N1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H28N4O3S/c1-2-34(31,32)30-16-14-20(15-17-30)23-12-13-24-26(27-23)29-25(28-24)21-8-10-22(11-9-21)33-18-19-6-4-3-5-7-19/h3-13,20H,2,14-18H2,1H3,(H,27,28,29)
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US Patent
n/an/a 148n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364135
PNG
(US9856252, 27)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C25H27N5O3S/c1-2-34(31,32)30-16-14-29(15-17-30)23-13-12-22-25(27-23)28-24(26-22)20-8-10-21(11-9-20)33-18-19-6-4-3-5-7-19/h3-13H,2,14-18H2,1H3,(H,26,27,28)
PDB

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US Patent
n/an/a 148n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364207
PNG
(US9856252, 99)
Show SMILES CN1CCCC(C1)c1ccc2nc([nH]c2n1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1/C25H26N4O/c1-29-15-5-6-20(16-29)22-13-14-23-25(26-22)28-24(27-23)19-11-9-18(10-12-19)17-30-21-7-3-2-4-8-21/h2-4,7-14,20H,5-6,15-17H2,1H3,(H,26,27,28)
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PC sid
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US Patent
n/an/a 148n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364194
PNG
(US9856252, 86)
Show SMILES CN1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O/c1-29-15-13-19(14-16-29)22-11-12-23-25(26-22)28-24(27-23)20-9-7-18(8-10-20)17-30-21-5-3-2-4-6-21/h2-12,19H,13-17H2,1H3,(H,26,27,28)
PDB

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n/an/a 151n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364193
PNG
(US9856252, 85)
Show SMILES C(Oc1ccccc1)c1ccc(cc1)-c1nc2ccc(nc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C24H24N4O/c1-2-4-20(5-3-1)29-16-17-6-8-19(9-7-17)23-27-22-11-10-21(26-24(22)28-23)18-12-14-25-15-13-18/h1-11,18,25H,12-16H2,(H,26,27,28)
PDB

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US Patent
n/an/a 151n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364206
PNG
(US9856252, 98)
Show SMILES CC(=O)N1CCC(=CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H24N4O2/c1-18(31)30-15-13-20(14-16-30)23-11-12-24-26(27-23)29-25(28-24)21-7-9-22(10-8-21)32-17-19-5-3-2-4-6-19/h2-13H,14-17H2,1H3,(H,27,28,29)
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n/an/a 166n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364112
PNG
(US9856252, 4)
Show SMILES Clc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H14ClN3O/c20-16-10-11-21-19-17(16)22-18(23-19)14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-11H,12H2,(H,21,22,23)
PDB

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n/an/a 182n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364155
PNG
(US9856252, 47)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C23H23N5O/c1-2-4-17(5-3-1)16-29-19-8-6-18(7-9-19)22-25-20-10-11-21(26-23(20)27-22)28-14-12-24-13-15-28/h1-11,24H,12-16H2,(H,25,26,27)
PDB

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PC sid
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US Patent
n/an/a 197n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364143
PNG
(US9856252, 35)
Show SMILES C(Oc1ccccc1)c1ccc(cc1)-c1nc2ccc(nc2[nH]1)C1CCCNC1
Show InChI InChI=1/C24H24N4O/c1-2-6-20(7-3-1)29-16-17-8-10-18(11-9-17)23-27-22-13-12-21(26-24(22)28-23)19-5-4-14-25-15-19/h1-3,6-13,19,25H,4-5,14-16H2,(H,26,27,28)
PDB

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n/an/a 204n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364171
PNG
(US9856252, 63)
Show SMILES Cn1cc(cn1)-c1cc(ccc1OCc1ccccc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C28H28N6O/c1-34-17-23(16-31-34)24-13-21(7-8-26(24)35-18-19-5-3-2-4-6-19)27-32-25-14-22(15-30-28(25)33-27)20-9-11-29-12-10-20/h2-8,13-17,20,29H,9-12,18H2,1H3,(H,30,32,33)
PDB

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n/an/a 215n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364205
PNG
(US9856252, 97)
Show SMILES CCS(=O)(=O)N1CCC(=CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H26N4O3S/c1-2-34(31,32)30-16-14-20(15-17-30)23-12-13-24-26(27-23)29-25(28-24)21-8-10-22(11-9-21)33-18-19-6-4-3-5-7-19/h3-14H,2,15-18H2,1H3,(H,27,28,29)
PDB

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n/an/a 217n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364148
PNG
(US9856252, 40)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C24H24N4O/c1-2-4-17(5-3-1)16-29-20-8-6-19(7-9-20)23-27-22-11-10-21(26-24(22)28-23)18-12-14-25-15-13-18/h1-11,18,25H,12-16H2,(H,26,27,28)
PDB

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PC sid
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n/an/a 223n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364209
PNG
(US9856252, 101)
Show SMILES CC1(O)CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O2/c1-25(30)13-15-29(16-14-25)22-12-11-21-24(27-22)28-23(26-21)19-7-9-20(10-8-19)31-17-18-5-3-2-4-6-18/h2-12,30H,13-17H2,1H3,(H,26,27,28)
PDB

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PC cid
PC sid
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US Patent
n/an/a 224n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364173
PNG
(US9856252, 65)
Show SMILES Fc1cc(ccc1OCc1ccccc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C24H23FN4O/c25-20-12-18(6-7-22(20)30-15-16-4-2-1-3-5-16)23-28-21-13-19(14-27-24(21)29-23)17-8-10-26-11-9-17/h1-7,12-14,17,26H,8-11,15H2,(H,27,28,29)
PDB

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PC cid
PC sid
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n/an/a 276n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364200
PNG
(US9856252, 92)
Show SMILES O=S(=O)(C1CC1)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H27N5O3S/c32-35(33,22-10-11-22)31-16-14-30(15-17-31)24-13-12-23-26(28-24)29-25(27-23)20-6-8-21(9-7-20)34-18-19-4-2-1-3-5-19/h1-9,12-13,22H,10-11,14-18H2,(H,27,28,29)
PDB

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PC sid
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n/an/a 279n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364183
PNG
(US9856252, 75)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)c(OC)c1
Show InChI InChI=1S/C26H29N5O4S/c1-3-36(32,33)31-15-13-30(14-16-31)24-12-10-21-26(28-24)29-25(27-21)20-9-11-22(23(17-20)34-2)35-18-19-7-5-4-6-8-19/h4-12,17H,3,13-16,18H2,1-2H3,(H,27,28,29)
PDB

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n/an/a 306n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364158
PNG
(US9856252, 50)
Show SMILES NCC1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1/C25H27N5O/c26-15-19-7-4-14-30(16-19)23-13-12-22-25(28-23)29-24(27-22)20-8-10-21(11-9-20)31-17-18-5-2-1-3-6-18/h1-3,5-6,8-13,19H,4,7,14-17,26H2,(H,27,28,29)
PDB

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n/an/a 317n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364208
PNG
(US9856252, 100)
Show SMILES C(Oc1ccc(cc1)-c1nc2cc(cnc2[nH]1)N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C23H23N5O/c1-2-4-17(5-3-1)16-29-20-8-6-18(7-9-20)22-26-21-14-19(15-25-23(21)27-22)28-12-10-24-11-13-28/h1-9,14-15,24H,10-13,16H2,(H,25,26,27)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 327n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364170
PNG
(US9856252, 62)
Show SMILES Brc1cc(ccc1OCc1ccccc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C24H23BrN4O/c25-20-12-18(6-7-22(20)30-15-16-4-2-1-3-5-16)23-28-21-13-19(14-27-24(21)29-23)17-8-10-26-11-9-17/h1-7,12-14,17,26H,8-11,15H2,(H,27,28,29)
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 331n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364166
PNG
(US9856252, 58)
Show SMILES Fc1cccc(COc2ccc(cc2)-c2nc3ccc(nc3[nH]2)N2CCNCC2)c1
Show InChI InChI=1S/C23H22FN5O/c24-18-3-1-2-16(14-18)15-30-19-6-4-17(5-7-19)22-26-20-8-9-21(27-23(20)28-22)29-12-10-25-11-13-29/h1-9,14,25H,10-13,15H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364151
PNG
(US9856252, 43)
Show SMILES Cc1cc(N)nc2[nH]c(nc12)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C20H18N4O/c1-13-11-17(21)22-20-18(13)23-19(24-20)15-9-7-14(8-10-15)12-25-16-5-3-2-4-6-16/h2-11H,12H2,1H3,(H3,21,22,23,24)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364172
PNG
(US9856252, 64)
Show SMILES C(Oc1ccc(cc1-c1cccnc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C29H27N5O/c1-2-5-20(6-3-1)19-35-27-9-8-22(15-25(27)23-7-4-12-31-17-23)28-33-26-16-24(18-32-29(26)34-28)21-10-13-30-14-11-21/h1-9,12,15-18,21,30H,10-11,13-14,19H2,(H,32,33,34)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364121
PNG
(US9856252, 13)
Show SMILES CC(=O)N1CCC(CC1)c1cnc2[nH]c(nc2c1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H26N4O2/c1-18(31)30-13-11-20(12-14-30)22-15-24-26(27-16-22)29-25(28-24)21-7-9-23(10-8-21)32-17-19-5-3-2-4-6-19/h2-10,15-16,20H,11-14,17H2,1H3,(H,27,28,29)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364195
PNG
(US9856252, 87)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O3S/c1-33(30,31)29-15-13-19(14-16-29)22-11-12-23-25(26-22)28-24(27-23)20-7-9-21(10-8-20)32-17-18-5-3-2-4-6-18/h2-12,19H,13-17H2,1H3,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364118
PNG
(US9856252, 10)
Show SMILES CC(=O)N1CCC(CC1)c1cnc2[nH]c(nc2c1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C26H26N4O2/c1-18(31)30-13-11-20(12-14-30)22-15-24-26(27-16-22)29-25(28-24)21-9-7-19(8-10-21)17-32-23-5-3-2-4-6-23/h2-10,15-16,20H,11-14,17H2,1H3,(H,27,28,29)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364163
PNG
(US9856252, 55)
Show SMILES NCC1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C25H27N5O/c26-16-18-12-14-30(15-13-18)23-11-10-22-25(28-23)29-24(27-22)20-6-8-21(9-7-20)31-17-19-4-2-1-3-5-19/h1-11,18H,12-17,26H2,(H,27,28,29)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364117
PNG
(US9856252, 9)
Show SMILES C(Oc1ccccc1)c1ccc(cc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C24H24N4O/c1-2-4-21(5-3-1)29-16-17-6-8-19(9-7-17)23-27-22-14-20(15-26-24(22)28-23)18-10-12-25-13-11-18/h1-9,14-15,18,25H,10-13,16H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364177
PNG
(US9856252, 69)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)c(c1)-c1cnn(C)c1
Show InChI InChI=1S/C29H31N7O3S/c1-3-40(37,38)36-15-13-35(14-16-36)27-12-10-25-29(32-27)33-28(31-25)22-9-11-26(39-20-21-7-5-4-6-8-21)24(17-22)23-18-30-34(2)19-23/h4-12,17-19H,3,13-16,20H2,1-2H3,(H,31,32,33)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364156
PNG
(US9856252, 48)
Show SMILES CN(C)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H20N4O/c1-25(2)19-13-12-18-21(23-19)24-20(22-18)16-8-10-17(11-9-16)26-14-15-6-4-3-5-7-15/h3-13H,14H2,1-2H3,(H,22,23,24)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364196
PNG
(US9856252, 88)
Show SMILES CCOC(=O)N1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C27H28N4O3/c1-2-33-27(32)31-16-14-20(15-17-31)23-12-13-24-26(28-23)30-25(29-24)21-8-10-22(11-9-21)34-18-19-6-4-3-5-7-19/h3-13,20H,2,14-18H2,1H3,(H,28,29,30)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364119
PNG
(US9856252, 11)
Show SMILES CN1CCC(CC1)c1cnc2[nH]c(nc2c1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O/c1-29-13-11-19(12-14-29)21-15-23-25(26-16-21)28-24(27-23)20-9-7-18(8-10-20)17-30-22-5-3-2-4-6-22/h2-10,15-16,19H,11-14,17H2,1H3,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364130
PNG
(US9856252, 22)
Show SMILES CC(=O)NCCNc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-16(29)24-13-14-25-21-12-11-20-23(27-21)28-22(26-20)18-7-9-19(10-8-18)30-15-17-5-3-2-4-6-17/h2-12H,13-15H2,1H3,(H,24,29)(H2,25,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364131
PNG
(US9856252, 23)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCSCC1)c1ccccc1
Show InChI InChI=1S/C23H22N4OS/c1-2-4-17(5-3-1)16-28-19-8-6-18(7-9-19)22-24-20-10-11-21(25-23(20)26-22)27-12-14-29-15-13-27/h1-11H,12-16H2,(H,24,25,26)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364167
PNG
(US9856252, 59)
Show SMILES Fc1ccc(COc2ccc(cc2)-c2nc3ccc(nc3[nH]2)N2CCNCC2)cc1
Show InChI InChI=1S/C23H22FN5O/c24-18-5-1-16(2-6-18)15-30-19-7-3-17(4-8-19)22-26-20-9-10-21(27-23(20)28-22)29-13-11-25-12-14-29/h1-10,25H,11-15H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364179
PNG
(US9856252, 71)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)c(c1)-c1cccnc1
Show InChI InChI=1S/C30H30N6O3S/c1-2-40(37,38)36-17-15-35(16-18-36)28-13-11-26-30(33-28)34-29(32-26)23-10-12-27(39-21-22-7-4-3-5-8-22)25(19-23)24-9-6-14-31-20-24/h3-14,19-20H,2,15-18,21H2,1H3,(H,32,33,34)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364159
PNG
(US9856252, 51)
Show SMILES C(Nc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1)C1CCCCN1
Show InChI InChI=1/C25H27N5O/c1-2-6-18(7-3-1)17-31-21-11-9-19(10-12-21)24-28-22-13-14-23(29-25(22)30-24)27-16-20-8-4-5-15-26-20/h1-3,6-7,9-14,20,26H,4-5,8,15-17H2,(H2,27,28,29,30)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364211
PNG
(US9856252, 103)
Show SMILES Cc1nnc2CN(CCn12)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C25H23N7O/c1-17-29-30-23-15-31(13-14-32(17)23)22-12-11-21-25(27-22)28-24(26-21)19-7-9-20(10-8-19)33-16-18-5-3-2-4-6-18/h2-12H,13-16H2,1H3,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364132
PNG
(US9856252, 24)
Show SMILES O=S1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H22N4O2S/c28-30-14-12-27(13-15-30)21-11-10-20-23(25-21)26-22(24-20)18-6-8-19(9-7-18)29-16-17-4-2-1-3-5-17/h1-11H,12-16H2,(H,24,25,26)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364161
PNG
(US9856252, 53)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(NC3CCNCC3)nc2[nH]1)c1ccccc1
Show InChI InChI=1S/C24H25N5O/c1-2-4-17(5-3-1)16-30-20-8-6-18(7-9-20)23-27-21-10-11-22(28-24(21)29-23)26-19-12-14-25-15-13-19/h1-11,19,25H,12-16H2,(H2,26,27,28,29)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364162
PNG
(US9856252, 54)
Show SMILES NC1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H25N5O/c25-19-12-14-29(15-13-19)22-11-10-21-24(27-22)28-23(26-21)18-6-8-20(9-7-18)30-16-17-4-2-1-3-5-17/h1-11,19H,12-16,25H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364204
PNG
(US9856252, 96)
Show SMILES C(Sc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C23H23N5S/c1-2-4-17(5-3-1)16-29-19-8-6-18(7-9-19)22-25-20-10-11-21(26-23(20)27-22)28-14-12-24-13-15-28/h1-11,24H,12-16H2,(H,25,26,27)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364145
PNG
(US9856252, 37)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C24H18N4O/c1-2-4-17(5-3-1)16-29-20-8-6-19(7-9-20)23-27-22-11-10-21(26-24(22)28-23)18-12-14-25-15-13-18/h1-15H,16H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364174
PNG
(US9856252, 66)
Show SMILES COC(=O)c1cc(ccc1OCc1ccccc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C26H26N4O3/c1-32-26(31)21-13-19(7-8-23(21)33-16-17-5-3-2-4-6-17)24-29-22-14-20(15-28-25(22)30-24)18-9-11-27-12-10-18/h2-8,13-15,18,27H,9-12,16H2,1H3,(H,28,29,30)
PDB

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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364141
PNG
(US9856252, 33)
Show SMILES O=C1CN(CCN1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H21N5O2/c29-21-14-28(13-12-24-21)20-11-10-19-23(26-20)27-22(25-19)17-6-8-18(9-7-17)30-15-16-4-2-1-3-5-16/h1-11H,12-15H2,(H,24,29)(H,25,26,27)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364133
PNG
(US9856252, 25)
Show SMILES O=S1(=O)CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H22N4O3S/c28-31(29)14-12-27(13-15-31)21-11-10-20-23(25-21)26-22(24-20)18-6-8-19(9-7-18)30-16-17-4-2-1-3-5-17/h1-11H,12-16H2,(H,24,25,26)
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n/an/a 619n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364113
PNG
(US9856252, 5 | US9856252, 78)
Show SMILES Cc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O/c1-14-11-12-21-20-18(14)22-19(23-20)16-7-9-17(10-8-16)24-13-15-5-3-2-4-6-15/h2-12H,13H2,1H3,(H,21,22,23)
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n/an/a 633n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364113
PNG
(US9856252, 5 | US9856252, 78)
Show SMILES Cc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O/c1-14-11-12-21-20-18(14)22-19(23-20)16-7-9-17(10-8-16)24-13-15-5-3-2-4-6-15/h2-12H,13H2,1H3,(H,21,22,23)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364187
PNG
(US9856252, 79)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(CN3CCNCC3)nc2[nH]1)c1ccccc1
Show InChI InChI=1S/C24H25N5O/c1-2-4-18(5-3-1)17-30-21-9-6-19(7-10-21)23-27-22-11-8-20(26-24(22)28-23)16-29-14-12-25-13-15-29/h1-11,25H,12-17H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364188
PNG
(US9856252, 80)
Show SMILES CCOC(=O)Cc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H21N3O3/c1-2-28-21(27)14-18-10-13-20-23(24-18)26-22(25-20)17-8-11-19(12-9-17)29-15-16-6-4-3-5-7-16/h3-13H,2,14-15H2,1H3,(H,24,25,26)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364144
PNG
(US9856252, 36)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)-c1cccnc1)c1ccccc1
Show InChI InChI=1S/C24H18N4O/c1-2-5-17(6-3-1)16-29-20-10-8-18(9-11-20)23-27-22-13-12-21(26-24(22)28-23)19-7-4-14-25-15-19/h1-15H,16H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364154
PNG
(US9856252, 46)
Show SMILES C[C@@H](N)C(=O)N1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18(28)27(33)32-15-13-20(14-16-32)23-11-12-24-26(29-23)31-25(30-24)21-7-9-22(10-8-21)34-17-19-5-3-2-4-6-19/h2-12,18,20H,13-17,28H2,1H3,(H,29,30,31)/t18-/m1/s1
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364150
PNG
(US9856252, 42)
Show SMILES Clc1cc(nc2nc([nH]c12)-c1ccc(COc2ccccc2)cc1)C1CCNCC1
Show InChI InChI=1S/C24H23ClN4O/c25-20-14-21(17-10-12-26-13-11-17)27-24-22(20)28-23(29-24)18-8-6-16(7-9-18)15-30-19-4-2-1-3-5-19/h1-9,14,17,26H,10-13,15H2,(H,27,28,29)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364147
PNG
(US9856252, 39)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C29H32N4O3/c1-29(2,3)36-28(34)33-17-15-21(16-18-33)24-13-14-25-27(30-24)32-26(31-25)22-9-11-23(12-10-22)35-19-20-7-5-4-6-8-20/h4-14,21H,15-19H2,1-3H3,(H,30,31,32)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364116
PNG
(US9856252, 8)
Show SMILES C(Oc1ccc(cc1)-c1nc2c(ccnc2[nH]1)C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C24H24N4O/c1-2-4-17(5-3-1)16-29-20-8-6-19(7-9-20)23-27-22-21(12-15-26-24(22)28-23)18-10-13-25-14-11-18/h1-9,12,15,18,25H,10-11,13-14,16H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364129
PNG
(US9856252, 21)
Show SMILES O=C1CNCCN1c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H21N5O2/c29-21-14-24-12-13-28(21)20-11-10-19-23(26-20)27-22(25-19)17-6-8-18(9-7-17)30-15-16-4-2-1-3-5-16/h1-11,24H,12-15H2,(H,25,26,27)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364199
PNG
(US9856252, 91)
Show SMILES CS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H25N5O3S/c1-33(30,31)29-15-13-28(14-16-29)22-12-11-21-24(26-22)27-23(25-21)19-7-9-20(10-8-19)32-17-18-5-3-2-4-6-18/h2-12H,13-17H2,1H3,(H,25,26,27)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364140
PNG
(US9856252, 32)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Nc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C29H33N5O3/c1-29(2,3)37-28(35)34-17-15-22(16-18-34)30-25-14-13-24-27(32-25)33-26(31-24)21-9-11-23(12-10-21)36-19-20-7-5-4-6-8-20/h4-14,22H,15-19H2,1-3H3,(H2,30,31,32,33)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364128
PNG
(US9856252, 20)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(Nc3cn[nH]c3)nc2[nH]1)c1ccccc1
Show InChI InChI=1S/C22H18N6O/c1-2-4-15(5-3-1)14-29-18-8-6-16(7-9-18)21-26-19-10-11-20(27-22(19)28-21)25-17-12-23-24-13-17/h1-13H,14H2,(H,23,24)(H2,25,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364192
PNG
(US9856252, 84)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C29H32N4O3/c1-29(2,3)36-28(34)33-17-15-21(16-18-33)24-13-14-25-27(30-24)32-26(31-25)22-11-9-20(10-12-22)19-35-23-7-5-4-6-8-23/h4-14,21H,15-19H2,1-3H3,(H,30,31,32)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364115
PNG
(US9856252, 7)
Show SMILES COc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O2/c1-24-17-11-12-21-20-18(17)22-19(23-20)15-7-9-16(10-8-15)25-13-14-5-3-2-4-6-14/h2-12H,13H2,1H3,(H,21,22,23)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364185
PNG
(US9856252, 77)
Show SMILES OC(=O)Cc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H17N3O3/c25-18(26)12-16-10-11-22-21-19(16)23-20(24-21)15-6-8-17(9-7-15)27-13-14-4-2-1-3-5-14/h1-11H,12-13H2,(H,25,26)(H,22,23,24)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364126
PNG
(US9856252, 18)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(OC3CCNCC3)nc2[nH]1)c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-17(5-3-1)16-29-19-8-6-18(7-9-19)23-26-21-10-11-22(27-24(21)28-23)30-20-12-14-25-15-13-20/h1-11,20,25H,12-16H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364160
PNG
(US9856252, 52)
Show SMILES C(Nc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1)C1CCNCC1
Show InChI InChI=1S/C25H27N5O/c1-2-4-19(5-3-1)17-31-21-8-6-20(7-9-21)24-28-22-10-11-23(29-25(22)30-24)27-16-18-12-14-26-15-13-18/h1-11,18,26H,12-17H2,(H2,27,28,29,30)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364137
PNG
(US9856252, 29)
Show SMILES CC(C)(C)OC(=O)N1CCCCC1CNc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1/C30H35N5O3/c1-30(2,3)38-29(36)35-18-8-7-11-23(35)19-31-26-17-16-25-28(33-26)34-27(32-25)22-12-14-24(15-13-22)37-20-21-9-5-4-6-10-21/h4-6,9-10,12-17,23H,7-8,11,18-20H2,1-3H3,(H2,31,32,33,34)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364165
PNG
(US9856252, 57)
Show SMILES Fc1ccccc1COc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCNCC1
Show InChI InChI=1S/C23H22FN5O/c24-19-4-2-1-3-17(19)15-30-18-7-5-16(6-8-18)22-26-20-9-10-21(27-23(20)28-22)29-13-11-25-12-14-29/h1-10,25H,11-15H2,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364122
PNG
(US9856252, 14)
Show SMILES FC(F)(F)c1ccc(COc2ccc(cc2)-c2nc3cc(cnc3[nH]2)C2CCNCC2)cc1
Show InChI InChI=1S/C25H23F3N4O/c26-25(27,28)20-5-1-16(2-6-20)15-33-21-7-3-18(4-8-21)23-31-22-13-19(14-30-24(22)32-23)17-9-11-29-12-10-17/h1-8,13-14,17,29H,9-12,15H2,(H,30,31,32)
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n/an/a 1.01E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364202
PNG
(US9856252, 94)
Show SMILES CN(C)C(=O)Cc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H22N4O2/c1-27(2)20(28)14-18-12-13-24-23-21(18)25-22(26-23)17-8-10-19(11-9-17)29-15-16-6-4-3-5-7-16/h3-13H,14-15H2,1-2H3,(H,24,25,26)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364142
PNG
(US9856252, 34)
Show SMILES CC(C)(C)OC(=O)N1CCCC(C1)c1ccc2nc([nH]c2n1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1/C29H32N4O3/c1-29(2,3)36-28(34)33-17-7-8-22(18-33)24-15-16-25-27(30-24)32-26(31-25)21-13-11-20(12-14-21)19-35-23-9-5-4-6-10-23/h4-6,9-16,22H,7-8,17-19H2,1-3H3,(H,30,31,32)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364210
PNG
(US9856252, 102)
Show SMILES C(Oc1ccccc1)c1nc(cs1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C21H21N5OS/c1-2-4-16(5-3-1)27-12-19-24-18(13-28-19)21-25-17-10-15(11-23-20(17)26-21)14-6-8-22-9-7-14/h1-5,10-11,13-14,22H,6-9,12H2,(H,23,25,26)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364178
PNG
(US9856252, 70)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)c(c1)-c1ccn[nH]1
Show InChI InChI=1S/C28H29N7O3S/c1-2-39(36,37)35-16-14-34(15-17-35)26-11-9-24-28(31-26)32-27(30-24)21-8-10-25(22(18-21)23-12-13-29-33-23)38-19-20-6-4-3-5-7-20/h3-13,18H,2,14-17,19H2,1H3,(H,29,33)(H,30,31,32)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364191
PNG
(US9856252, 83)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cnc2[nH]c(nc2c1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O3S/c1-33(30,31)29-13-11-19(12-14-29)21-15-23-25(26-16-21)28-24(27-23)20-7-9-22(10-8-20)32-17-18-5-3-2-4-6-18/h2-10,15-16,19H,11-14,17H2,1H3,(H,26,27,28)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364139
PNG
(US9856252, 31)
Show SMILES CC(C)(C)OC(=O)N1CCC(CNc2ccc3nc([nH]c3n2)-c2ccc(OCc3ccccc3)cc2)CC1
Show InChI InChI=1S/C30H35N5O3/c1-30(2,3)38-29(36)35-17-15-21(16-18-35)19-31-26-14-13-25-28(33-26)34-27(32-25)23-9-11-24(12-10-23)37-20-22-7-5-4-6-8-22/h4-14,21H,15-20H2,1-3H3,(H2,31,32,33,34)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364176
PNG
(US9856252, 68)
Show SMILES NC(=O)c1cc(ccc1OCc1ccccc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C25H25N5O2/c26-23(31)20-12-18(6-7-22(20)32-15-16-4-2-1-3-5-16)24-29-21-13-19(14-28-25(21)30-24)17-8-10-27-11-9-17/h1-7,12-14,17,27H,8-11,15H2,(H2,26,31)(H,28,29,30)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364114
PNG
(US9856252, 6)
Show SMILES Cc1ccnc2[nH]c(nc12)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O/c1-14-11-12-21-20-18(14)22-19(23-20)16-9-7-15(8-10-16)13-24-17-5-3-2-4-6-17/h2-12H,13H2,1H3,(H,21,22,23)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364197
PNG
(US9856252, 89)
Show SMILES O=S(=O)(C1CC1)N1CCC(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C27H28N4O3S/c32-35(33,23-10-11-23)31-16-14-20(15-17-31)24-12-13-25-27(28-24)30-26(29-25)21-6-8-22(9-7-21)34-18-19-4-2-1-3-5-19/h1-9,12-13,20,23H,10-11,14-18H2,(H,28,29,30)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364182
PNG
(US9856252, 74)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)c(C)c1
Show InChI InChI=1S/C26H29N5O3S/c1-3-35(32,33)31-15-13-30(14-16-31)24-12-10-22-26(28-24)29-25(27-22)21-9-11-23(19(2)17-21)34-18-20-7-5-4-6-8-20/h4-12,17H,3,13-16,18H2,1-2H3,(H,27,28,29)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364149
PNG
(US9856252, 41)
Show SMILES Clc1cc(Cl)c2[nH]c(nc2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H13Cl2N3O/c20-15-10-16(21)22-19-17(15)23-18(24-19)13-6-8-14(9-7-13)25-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,22,23,24)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364109
PNG
(US9856252, 1)
Show SMILES C(Oc1ccccc1)c1ccc(cc1)-c1nc2cccnc2[nH]1
Show InChI InChI=1S/C19H15N3O/c1-2-5-16(6-3-1)23-13-14-8-10-15(11-9-14)18-21-17-7-4-12-20-19(17)22-18/h1-12H,13H2,(H,20,21,22)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364213
PNG
(US9856252, 105)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)C1CC1)c1ccccc1
Show InChI InChI=1S/C22H19N3O/c1-2-4-15(5-3-1)14-26-18-10-8-17(9-11-18)21-24-20-13-12-19(16-6-7-16)23-22(20)25-21/h1-5,8-13,16H,6-7,14H2,(H,23,24,25)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364168
PNG
(US9856252, 60)
Show SMILES FC(F)(F)c1ccccc1COc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCNCC1
Show InChI InChI=1S/C24H22F3N5O/c25-24(26,27)19-4-2-1-3-17(19)15-33-18-7-5-16(6-8-18)22-29-20-9-10-21(30-23(20)31-22)32-13-11-28-12-14-32/h1-10,28H,11-15H2,(H,29,30,31)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364215
PNG
(US9856252, 107)
Show SMILES Cn1cc(cn1)-c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H19N5O/c1-28-14-18(13-24-28)20-11-12-21-23(25-20)27-22(26-21)17-7-9-19(10-8-17)29-15-16-5-3-2-4-6-16/h2-14H,15H2,1H3,(H,25,26,27)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364136
PNG
(US9856252, 28)
Show SMILES CC(C)(C)OC(=O)NCC1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1/C30H35N5O3/c1-30(2,3)38-29(36)31-18-22-10-7-17-35(19-22)26-16-15-25-28(33-26)34-27(32-25)23-11-13-24(14-12-23)37-20-21-8-5-4-6-9-21/h4-6,8-9,11-16,22H,7,10,17-20H2,1-3H3,(H,31,36)(H,32,33,34)
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n/an/a 1.68E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364127
PNG
(US9856252, 19)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C23H22N4O2/c1-2-4-17(5-3-1)16-29-19-8-6-18(7-9-19)22-24-20-10-11-21(25-23(20)26-22)27-12-14-28-15-13-27/h1-11H,12-16H2,(H,24,25,26)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364123
PNG
(US9856252, 15)
Show SMILES CC(C)(C)OC(=O)N1CCCC(C1)c1cnc2[nH]c(nc2c1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1/C29H32N4O3/c1-29(2,3)36-28(34)33-15-7-8-22(18-33)23-16-25-27(30-17-23)32-26(31-25)21-13-11-20(12-14-21)19-35-24-9-5-4-6-10-24/h4-6,9-14,16-17,22H,7-8,15,18-19H2,1-3H3,(H,30,31,32)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364164
PNG
(US9856252, 56)
Show SMILES FC(F)(F)c1ccc(COc2ccc(cc2)-c2nc3ccc(nc3[nH]2)N2CCNCC2)cc1
Show InChI InChI=1S/C24H22F3N5O/c25-24(26,27)18-5-1-16(2-6-18)15-33-19-7-3-17(4-8-19)22-29-20-9-10-21(30-23(20)31-22)32-13-11-28-12-14-32/h1-10,28H,11-15H2,(H,29,30,31)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364181
PNG
(US9856252, 73)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)c(c1)-c1cn[nH]c1
Show InChI InChI=1S/C28H29N7O3S/c1-2-39(36,37)35-14-12-34(13-15-35)26-11-9-24-28(32-26)33-27(31-24)21-8-10-25(23(16-21)22-17-29-30-18-22)38-19-20-6-4-3-5-7-20/h3-11,16-18H,2,12-15,19H2,1H3,(H,29,30)(H,31,32,33)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364184
PNG
(US9856252, 76)
Show SMILES CCOC(=O)Cc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H21N3O3/c1-2-28-20(27)14-18-12-13-24-23-21(18)25-22(26-23)17-8-10-19(11-9-17)29-15-16-6-4-3-5-7-16/h3-13H,2,14-15H2,1H3,(H,24,25,26)
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Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364201
PNG
(US9856252, 93)
Show SMILES CNC(=O)Cc1ccnc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H20N4O2/c1-23-19(27)13-17-11-12-24-22-20(17)25-21(26-22)16-7-9-18(10-8-16)28-14-15-5-3-2-4-6-15/h2-12H,13-14H2,1H3,(H,23,27)(H,24,25,26)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364110
PNG
(US9856252, 2)
Show SMILES C(Oc1ccc(cc1)-c1nc2ncccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-2-5-14(6-3-1)13-23-16-10-8-15(9-11-16)18-21-17-7-4-12-20-19(17)22-18/h1-12H,13H2,(H,20,21,22)
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n/an/a 2.22E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364190
PNG
(US9856252, 82)
Show SMILES OC(=O)Cc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H17N3O3/c25-19(26)12-16-8-11-18-21(22-16)24-20(23-18)15-6-9-17(10-7-15)27-13-14-4-2-1-3-5-14/h1-11H,12-13H2,(H,25,26)(H,22,23,24)
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n/an/a 2.39E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364146
PNG
(US9856252, 38)
Show SMILES Cn1ccc(n1)-c1ccc2nc([nH]c2n1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C23H19N5O/c1-28-14-13-20(27-28)19-11-12-21-23(24-19)26-22(25-21)17-9-7-16(8-10-17)15-29-18-5-3-2-4-6-18/h2-14H,15H2,1H3,(H,24,25,26)
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n/an/a 2.39E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364157
PNG
(US9856252, 49)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1ccc(OCc2ccccc2)cc1)C1CCNCC1
Show InChI InChI=1S/C26H27N3O/c1-18-15-22(20-11-13-27-14-12-20)16-24-25(18)29-26(28-24)21-7-9-23(10-8-21)30-17-19-5-3-2-4-6-19/h2-10,15-16,20,27H,11-14,17H2,1H3,(H,28,29)
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n/an/a 2.63E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364212
PNG
(US9856252, 104)
Show SMILES C(c1ccccc1)n1cc(cn1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C21H22N6/c1-2-4-15(5-3-1)13-27-14-18(12-24-27)20-25-19-10-17(11-23-21(19)26-20)16-6-8-22-9-7-16/h1-5,10-12,14,16,22H,6-9,13H2,(H,23,25,26)
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n/an/a 2.65E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364189
PNG
(US9856252, 81)
Show SMILES CCOC(=O)Cc1ccc2nc([nH]c2n1)-c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C23H21N3O3/c1-2-28-21(27)14-18-12-13-20-23(24-18)26-22(25-20)17-10-8-16(9-11-17)15-29-19-6-4-3-5-7-19/h3-13H,2,14-15H2,1H3,(H,24,25,26)
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n/an/a 2.65E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364138
PNG
(US9856252, 30)
Show SMILES CN(C1CCCN(C1)C(=O)OC(C)(C)C)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1/C30H35N5O3/c1-30(2,3)38-29(36)35-18-8-11-23(19-35)34(4)26-17-16-25-28(32-26)33-27(31-25)22-12-14-24(15-13-22)37-20-21-9-6-5-7-10-21/h5-7,9-10,12-17,23H,8,11,18-20H2,1-4H3,(H,31,32,33)
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n/an/a 2.66E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364152
PNG
(US9856252, 44)
Show SMILES OC(c1ccccc1)c1ccc(cc1)-c1nc2ccc(Cl)nc2[nH]1
Show InChI InChI=1/C19H14ClN3O/c20-16-11-10-15-19(22-16)23-18(21-15)14-8-6-13(7-9-14)17(24)12-4-2-1-3-5-12/h1-11,17,24H,(H,21,22,23)
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n/an/a 2.67E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364203
PNG
(US9856252, 95)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(SCc2ccccc2)cc1
Show InChI InChI=1S/C28H31N5O2S/c1-28(2,3)35-27(34)33-17-15-32(16-18-33)24-14-13-23-26(30-24)31-25(29-23)21-9-11-22(12-10-21)36-19-20-7-5-4-6-8-20/h4-14H,15-19H2,1-3H3,(H,29,30,31)
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n/an/a 2.82E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364169
PNG
(US9856252, 61)
Show SMILES CC(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCNCC1)c1ccccc1
Show InChI InChI=1/C24H25N5O/c1-17(18-5-3-2-4-6-18)30-20-9-7-19(8-10-20)23-26-21-11-12-22(27-24(21)28-23)29-15-13-25-14-16-29/h2-12,17,25H,13-16H2,1H3,(H,26,27,28)
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n/an/a 2.87E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364175
PNG
(US9856252, 67)
Show SMILES OC(=O)c1cc(ccc1OCc1ccccc1)-c1nc2cc(cnc2[nH]1)C1CCNCC1
Show InChI InChI=1S/C25H24N4O3/c30-25(31)20-12-18(6-7-22(20)32-15-16-4-2-1-3-5-16)23-28-21-13-19(14-27-24(21)29-23)17-8-10-26-11-9-17/h1-7,12-14,17,26H,8-11,15H2,(H,30,31)(H,27,28,29)
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n/an/a 3.72E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364111
PNG
(US9856252, 3)
Show SMILES O=C(Nc1ccc(cc1)-c1nc2cccnc2[nH]1)c1ccccc1
Show InChI InChI=1S/C19H14N4O/c24-19(14-5-2-1-3-6-14)21-15-10-8-13(9-11-15)17-22-16-7-4-12-20-18(16)23-17/h1-12H,(H,21,24)(H,20,22,23)
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n/an/a 3.97E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364125
PNG
(US9856252, 17)
Show SMILES Clc1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H14ClN3O/c20-17-11-10-16-19(22-17)23-18(21-16)14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-11H,12H2,(H,21,22,23)
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n/an/a 4.09E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364214
PNG
(US9856252, 106)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)-c1cncnc1)c1ccccc1
Show InChI InChI=1S/C23H17N5O/c1-2-4-16(5-3-1)14-29-19-8-6-17(7-9-19)22-27-21-11-10-20(26-23(21)28-22)18-12-24-15-25-13-18/h1-13,15H,14H2,(H,26,27,28)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM364180
PNG
(US9856252, 72)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc2nc([nH]c2n1)-c1ccc(OCc2ccccc2)c(c1)-c1cncnc1
Show InChI InChI=1S/C29H29N7O3S/c1-2-40(37,38)36-14-12-35(13-15-36)27-11-9-25-29(33-27)34-28(32-25)22-8-10-26(39-19-21-6-4-3-5-7-21)24(16-22)23-17-30-20-31-18-23/h3-11,16-18,20H,2,12-15,19H2,1H3,(H,32,33,34)
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n/an/a 1.71E+4n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
The 6 μL assay reactions are run in Greiner brand black 384-well low volume plates. All reactions contained assay buffer (phosphate buffered sal...


US Patent US9856252 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%