BindingDB logo
myBDB logout

Patent code US9856257

Compile Data Set for Download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase


(Homo sapiens (Human))
BDBM364220
PNG
(US9856257, 5)
Show SMILES Cc1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C18H13F3N4O/c1-10-4-2-3-5-11(10)14-6-15-12(7-22-14)16-13(8-23-24-16)17(26)25(15)9-18(19,20)21/h2-8H,9H2,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364234
PNG
(US9856257, 19)
Show SMILES CNS(=O)(=O)c1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C18H14F3N5O3S/c1-22-30(28,29)15-5-3-2-4-10(15)13-6-14-11(7-23-13)16-12(8-24-25-16)17(27)26(14)9-18(19,20)21/h2-8,22H,9H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364246
PNG
(US9856257, 31)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C21H20F3N7O/c1-29-4-6-30(7-5-29)18-3-2-13(9-26-18)16-8-17-14(10-25-16)19-15(11-27-28-19)20(32)31(17)12-21(22,23)24/h2-3,8-11H,4-7,12H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364248
PNG
(US9856257, 33)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCC1
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)11-29-16-8-15(12-4-3-5-24-18(12)28-6-1-2-7-28)25-9-13(16)17-14(19(29)30)10-26-27-17/h3-5,8-10H,1-2,6-7,11H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364272
PNG
(US9856257, 57)
Show SMILES OCCc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H15F3N4O2/c20-19(21,22)10-26-15-7-12(13-4-2-1-3-11(13)5-6-27)8-23-17(15)16-14(18(26)28)9-24-25-16/h1-4,7-9,27H,5-6,10H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364237
PNG
(US9856257, 22)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C18H14F3N5O3S/c1-30(28,29)25-13-5-3-2-4-10(13)14-6-15-11(7-22-14)16-12(8-23-24-16)17(27)26(15)9-18(19,20)21/h2-8,25H,9H2,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364216
PNG
(US9856257, 1)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C16H9ClF3N5O/c17-14-8(2-1-3-21-14)11-4-12-9(5-22-11)13-10(6-23-24-13)15(26)25(12)7-16(18,19)20/h1-6H,7H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364255
PNG
(US9856257, 40)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H20F3N7O/c1-29-4-6-30(7-5-29)17-9-13(2-3-25-17)14-8-16-19(26-10-14)18-15(11-27-28-18)20(32)31(16)12-21(22,23)24/h2-3,8-11H,4-7,12H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364249
PNG
(US9856257, 34)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCNCC1
Show InChI InChI=1S/C21H20F3N7O/c22-21(23,24)12-31-17-9-16(27-10-14(17)18-15(20(31)32)11-28-29-18)13-3-1-5-26-19(13)30-7-2-4-25-6-8-30/h1,3,5,9-11,25H,2,4,6-8,12H2,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364268
PNG
(US9856257, 53)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ncccc1Cl
Show InChI InChI=1S/C16H9ClF3N5O/c17-10-2-1-3-21-12(10)8-4-11-14(22-5-8)13-9(6-23-24-13)15(26)25(11)7-16(18,19)20/h1-6H,7H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364229
PNG
(US9856257, 14)
Show SMILES COc1ccc(c(F)c1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C18H12F4N4O2/c1-28-9-2-3-10(13(19)4-9)14-5-15-11(6-23-14)16-12(7-24-25-16)17(27)26(15)8-18(20,21)22/h2-7H,8H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364281
PNG
(US9856257, 66)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccc(cc1)C(=O)C1CC1
Show InChI InChI=1S/C21H15F3N4O2/c22-21(23,24)10-28-16-7-14(8-25-18(16)17-15(20(28)30)9-26-27-17)11-1-3-12(4-2-11)19(29)13-5-6-13/h1-4,7-9,13H,5-6,10H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364221
PNG
(US9856257, 6)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C18H10F6N4O/c19-17(20,21)8-28-14-5-13(9-3-1-2-4-12(9)18(22,23)24)25-6-10(14)15-11(16(28)29)7-26-27-15/h1-7H,8H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50097412
PNG
(CHEMBL3586448 | US9856257, 37)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C16H9ClF3N5O/c17-14-9(2-1-3-21-14)8-4-11-13(22-5-8)12-10(6-23-24-12)15(26)25(11)7-16(18,19)20/h1-6H,7H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a 20n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364231
PNG
(US9856257, 16)
Show SMILES CNC(=O)c1cc(ccc1F)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C19H13F4N5O2/c1-24-17(29)10-4-9(2-3-13(10)20)14-5-15-11(6-25-14)16-12(7-26-27-16)18(30)28(15)8-19(21,22)23/h2-7H,8H2,1H3,(H,24,29)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364262
PNG
(US9856257, 47)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccccc1CNC1CC1
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)11-29-17-7-13(9-26-19(17)18-16(20(29)30)10-27-28-18)15-4-2-1-3-12(15)8-25-14-5-6-14/h1-4,7,9-10,14,25H,5-6,8,11H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50097401
PNG
(CHEMBL3586459 | US9856257, 3)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C21H20F3N7O/c1-29-4-6-30(7-5-29)18-8-13(2-3-25-18)16-9-17-14(10-26-16)19-15(11-27-28-19)20(32)31(17)12-21(22,23)24/h2-3,8-11H,4-7,12H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364257
PNG
(US9856257, 42)
Show SMILES Nc1cccc(n1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C16H11F3N6O/c17-16(18,19)7-25-11-4-8(10-2-1-3-12(20)23-10)5-21-14(11)13-9(15(25)26)6-22-24-13/h1-6H,7H2,(H2,20,23)(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364253
PNG
(US9856257, 38)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccccn1
Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)8-24-12-5-9(11-3-1-2-4-20-11)6-21-14(12)13-10(15(24)25)7-22-23-13/h1-7H,8H2,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364259
PNG
(US9856257, 44)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ncccc1C(F)(F)F
Show InChI InChI=1S/C17H9F6N5O/c18-16(19,20)7-28-11-4-8(12-10(17(21,22)23)2-1-3-24-12)5-25-14(11)13-9(15(28)29)6-26-27-13/h1-6H,7H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364251
PNG
(US9856257, 36)
Show SMILES Fc1ncccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C16H9F4N5O/c17-14-8(2-1-3-21-14)11-4-12-9(5-22-11)13-10(6-23-24-13)15(26)25(12)7-16(18,19)20/h1-6H,7H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364256
PNG
(US9856257, 41)
Show SMILES COC(=O)c1ncccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H12F3N5O3/c1-29-17(28)14-10(3-2-4-22-14)9-5-12-15(23-6-9)13-11(7-24-25-13)16(27)26(12)8-18(19,20)21/h2-7H,8H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 34n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364254
PNG
(US9856257, 39)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccncc1
Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)8-24-12-5-10(9-1-3-20-4-2-9)6-21-14(12)13-11(15(24)25)7-22-23-13/h1-7H,8H2,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364270
PNG
(US9856257, 55)
Show SMILES Nc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H12F3N5O/c18-17(19,20)8-25-13-5-9(10-3-1-2-4-12(10)21)6-22-15(13)14-11(16(25)26)7-23-24-14/h1-7H,8,21H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364276
PNG
(US9856257, 61)
Show SMILES Nc1cnccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C16H11F3N6O/c17-16(18,19)7-25-12-3-8(9-1-2-21-6-11(9)20)4-22-14(12)13-10(15(25)26)5-23-24-13/h1-6H,7,20H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364224
PNG
(US9856257, 9)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1cccc2cccnc12
Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)10-28-16-7-15(12-5-1-3-11-4-2-6-24-17(11)12)25-8-13(16)18-14(19(28)29)9-26-27-18/h1-9H,10H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364250
PNG
(US9856257, 35)
Show SMILES CCN(C)c1ncccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C19H17F3N6O/c1-3-27(2)17-11(5-4-6-23-17)14-7-15-12(8-24-14)16-13(9-25-26-16)18(29)28(15)10-19(20,21)22/h4-9H,3,10H2,1-2H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364267
PNG
(US9856257, 52)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccc(Cl)cn1
Show InChI InChI=1S/C16H9ClF3N5O/c17-9-1-2-11(21-5-9)8-3-12-14(22-4-8)13-10(6-23-24-13)15(26)25(12)7-16(18,19)20/h1-6H,7H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364261
PNG
(US9856257, 46)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cccnc1C#N
Show InChI InChI=1S/C17H9F3N6O/c18-17(19,20)8-26-13-4-9(10-2-1-3-22-12(10)5-21)6-23-15(13)14-11(16(26)27)7-24-25-14/h1-4,6-7H,8H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364238
PNG
(US9856257, 23)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1cccc(c1)-n1cccn1
Show InChI InChI=1S/C20H13F3N6O/c21-20(22,23)11-28-17-8-16(12-3-1-4-13(7-12)29-6-2-5-26-29)24-9-14(17)18-15(19(28)30)10-25-27-18/h1-10H,11H2,(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 41n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364280
PNG
(US9856257, 65)
Show SMILES CC(=O)c1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H13F3N4O2/c1-10(27)12-4-2-3-5-13(12)11-6-15-17(23-7-11)16-14(8-24-25-16)18(28)26(15)9-19(20,21)22/h2-8H,9H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 41n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364245
PNG
(US9856257, 30)
Show SMILES CCNS(=O)(=O)c1ccc(cc1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C19H16F3N5O3S/c1-2-25-31(29,30)12-5-3-11(4-6-12)15-7-16-13(8-23-15)17-14(9-24-26-17)18(28)27(16)10-19(20,21)22/h3-9,25H,2,10H2,1H3,(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364269
PNG
(US9856257, 54)
Show SMILES Cc1cc(nc(N)n1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C16H12F3N7O/c1-7-2-10(24-15(20)23-7)8-3-11-13(21-4-8)12-9(5-22-25-12)14(27)26(11)6-16(17,18)19/h2-5H,6H2,1H3,(H,22,25)(H2,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364222
PNG
(US9856257, 7)
Show SMILES Fc1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C17H10F4N4O/c18-12-4-2-1-3-9(12)13-5-14-10(6-22-13)15-11(7-23-24-15)16(26)25(14)8-17(19,20)21/h1-7H,8H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364277
PNG
(US9856257, 62)
Show SMILES CCCC(=O)Nc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H18F3N5O2/c1-2-5-17(30)27-15-7-4-3-6-13(15)12-8-16-19(25-9-12)18-14(10-26-28-18)20(31)29(16)11-21(22,23)24/h3-4,6-10H,2,5,11H2,1H3,(H,26,28)(H,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364233
PNG
(US9856257, 18)
Show SMILES CCOCc1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C20H17F3N4O2/c1-2-29-10-12-5-3-4-6-13(12)16-7-17-14(8-24-16)18-15(9-25-26-18)19(28)27(17)11-20(21,22)23/h3-9H,2,10-11H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 49n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50097411
PNG
(CHEMBL3586449 | US9856257, 67)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cccnc1
Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)8-24-12-4-10(9-2-1-3-20-5-9)6-21-14(12)13-11(15(24)25)7-22-23-13/h1-7H,8H2,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 52n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364239
PNG
(US9856257, 24)
Show SMILES Cc1nc(Cl)ccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C17H11ClF3N5O/c1-8-9(2-3-14(18)24-8)12-4-13-10(5-22-12)15-11(6-23-25-15)16(27)26(13)7-17(19,20)21/h2-6H,7H2,1H3,(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 54n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364274
PNG
(US9856257, 59)
Show SMILES Cc1cc(ncn1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C16H11F3N6O/c1-8-2-11(22-7-21-8)9-3-12-14(20-4-9)13-10(5-23-24-13)15(26)25(12)6-16(17,18)19/h2-5,7H,6H2,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364223
PNG
(US9856257, 8)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccncc1
Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)8-24-13-5-12(9-1-3-20-4-2-9)21-6-10(13)14-11(15(24)25)7-22-23-14/h1-7H,8H2,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364235
PNG
(US9856257, 20)
Show SMILES Oc1c(Cl)cccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C17H10ClF3N4O2/c18-11-3-1-2-8(15(11)26)12-4-13-9(5-22-12)14-10(6-23-24-14)16(27)25(13)7-17(19,20)21/h1-6,26H,7H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 61n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364273
PNG
(US9856257, 58)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ncccc1C#N
Show InChI InChI=1S/C17H9F3N6O/c18-17(19,20)8-26-12-4-10(13-9(5-21)2-1-3-22-13)6-23-15(12)14-11(16(26)27)7-24-25-14/h1-4,6-7H,8H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 61n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364263
PNG
(US9856257, 48)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cncnc1C1CCCC1
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)9-29-15-5-12(6-25-18(15)17-14(19(29)30)8-27-28-17)13-7-24-10-26-16(13)11-3-1-2-4-11/h5-8,10-11H,1-4,9H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364240
PNG
(US9856257, 25)
Show SMILES CC(C)NS(=O)(=O)c1ccc(cc1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C20H18F3N5O3S/c1-11(2)27-32(30,31)13-5-3-12(4-6-13)16-7-17-14(8-24-16)18-15(9-25-26-18)19(29)28(17)10-20(21,22)23/h3-9,11,27H,10H2,1-2H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364217
PNG
(US9856257, 2)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccccn1
Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)8-24-13-5-12(11-3-1-2-4-20-11)21-6-9(13)14-10(15(24)25)7-22-23-14/h1-7H,8H2,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 64n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364225
PNG
(US9856257, 10)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C18H10F6N4O2/c19-17(20,21)8-28-13-5-12(9-3-1-2-4-14(9)30-18(22,23)24)25-6-10(13)15-11(16(28)29)7-26-27-15/h1-7H,8H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 72n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364227
PNG
(US9856257, 12)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C21H18F3N5O2/c22-21(23,24)12-29-18-9-17(25-10-15(18)19-16(20(29)30)11-26-27-19)13-1-3-14(4-2-13)28-5-7-31-8-6-28/h1-4,9-11H,5-8,12H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364232
PNG
(US9856257, 17)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccccc1CN1CCOCC1
Show InChI InChI=1S/C22H20F3N5O2/c23-22(24,25)13-30-19-9-18(26-10-16(19)20-17(21(30)31)11-27-28-20)15-4-2-1-3-14(15)12-29-5-7-32-8-6-29/h1-4,9-11H,5-8,12-13H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364244
PNG
(US9856257, 29)
Show SMILES CN(C)S(=O)(=O)c1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C19H16F3N5O3S/c1-26(2)31(29,30)16-6-4-3-5-11(16)14-7-15-12(8-23-14)17-13(9-24-25-17)18(28)27(15)10-19(20,21)22/h3-9H,10H2,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 82n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364228
PNG
(US9856257, 13)
Show SMILES Nc1ccc(cn1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C16H11F3N6O/c17-16(18,19)7-25-12-3-11(8-1-2-13(20)22-4-8)21-5-9(12)14-10(15(25)26)6-23-24-14/h1-6H,7H2,(H2,20,22)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 102n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364241
PNG
(US9856257, 26)
Show SMILES CC(C)Oc1cc(ccn1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C19H16F3N5O2/c1-10(2)29-16-5-11(3-4-23-16)14-6-15-12(7-24-14)17-13(8-25-26-17)18(28)27(15)9-19(20,21)22/h3-8,10H,9H2,1-2H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 109n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364278
PNG
(US9856257, 63)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cncnc1C1CCCCC1
Show InChI InChI=1S/C21H19F3N6O/c22-21(23,24)10-30-16-6-13(7-26-19(16)18-15(20(30)31)9-28-29-18)14-8-25-11-27-17(14)12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 118n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364243
PNG
(US9856257, 28)
Show SMILES CCOc1ncccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C18H14F3N5O2/c1-2-28-16-10(4-3-5-22-16)13-6-14-11(7-23-13)15-12(8-24-25-15)17(27)26(14)9-18(19,20)21/h3-8H,2,9H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 146n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364236
PNG
(US9856257, 21)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccccc1OCCN1CCCC1
Show InChI InChI=1S/C23H22F3N5O2/c24-23(25,26)14-31-19-11-18(27-12-16(19)21-17(22(31)32)13-28-29-21)15-5-1-2-6-20(15)33-10-9-30-7-3-4-8-30/h1-2,5-6,11-13H,3-4,7-10,14H2,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 162n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364230
PNG
(US9856257, 15)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccc(cc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H16F3N5O2/c25-24(26,27)13-32-20-10-19(28-11-17(20)21-18(23(32)34)12-29-31-21)14-6-8-15(9-7-14)22(33)30-16-4-2-1-3-5-16/h1-12H,13H2,(H,29,31)(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 165n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364247
PNG
(US9856257, 32)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccccc1N1CCOCC1
Show InChI InChI=1S/C21H18F3N5O2/c22-21(23,24)12-29-18-9-16(25-10-14(18)19-15(20(29)30)11-26-27-19)13-3-1-2-4-17(13)28-5-7-31-8-6-28/h1-4,9-11H,5-8,12H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 187n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364275
PNG
(US9856257, 60)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C17H9F6N5O/c18-16(19,20)7-28-11-3-9(8-1-2-12(24-4-8)17(21,22)23)5-25-14(11)13-10(15(28)29)6-26-27-13/h1-6H,7H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 188n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364258
PNG
(US9856257, 43)
Show SMILES CN(C)c1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H16F3N5O/c1-26(2)14-6-4-3-5-12(14)11-7-15-17(23-8-11)16-13(9-24-25-16)18(28)27(15)10-19(20,21)22/h3-9H,10H2,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 196n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364242
PNG
(US9856257, 27)
Show SMILES COc1cncc(c1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C17H12F3N5O2/c1-27-10-2-9(4-21-5-10)13-3-14-11(6-22-13)15-12(7-23-24-15)16(26)25(14)8-17(18,19)20/h2-7H,8H2,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 199n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364279
PNG
(US9856257, 64)
Show SMILES CC(C)C(=O)Nc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H18F3N5O2/c1-11(2)19(30)27-15-6-4-3-5-13(15)12-7-16-18(25-8-12)17-14(9-26-28-17)20(31)29(16)10-21(22,23)24/h3-9,11H,10H2,1-2H3,(H,26,28)(H,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 201n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364260
PNG
(US9856257, 45)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C17H9F6N5O/c18-16(19,20)7-28-12-3-8(11-2-1-9(5-24-11)17(21,22)23)4-25-14(12)13-10(15(28)29)6-26-27-13/h1-6H,7H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 226n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364219
PNG
(US9856257, 4)
Show SMILES Fc1ccc(cc1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C17H10F4N4O/c18-10-3-1-9(2-4-10)13-5-14-11(6-22-13)15-12(7-23-24-15)16(26)25(14)8-17(19,20)21/h1-7H,8H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 234n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364271
PNG
(US9856257, 56)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H10F6N4O/c19-17(20,21)8-28-13-5-10(9-1-3-11(4-2-9)18(22,23)24)6-25-15(13)14-12(16(28)29)7-26-27-14/h1-7H,8H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 339n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364266
PNG
(US9856257, 51)
Show SMILES CC(C)c1ncncc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H15F3N6O/c1-9(2)14-11(5-22-8-24-14)10-3-13-16(23-4-10)15-12(6-25-26-15)17(28)27(13)7-18(19,20)21/h3-6,8-9H,7H2,1-2H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 379n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364265
PNG
(US9856257, 50)
Show SMILES CNCc1cccnc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H15F3N6O/c1-22-6-10-3-2-4-23-14(10)11-5-13-16(24-7-11)15-12(8-25-26-15)17(28)27(13)9-18(19,20)21/h2-5,7-8,22H,6,9H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 459n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364283
PNG
(US9856257, 68)
Show SMILES OC(=O)c1ncccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H10F3N5O3/c18-17(19,20)7-25-11-4-8(9-2-1-3-21-13(9)16(27)28)5-22-14(11)12-10(15(25)26)6-23-24-12/h1-6H,7H2,(H,23,24)(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 727n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364226
PNG
(US9856257, 11)
Show SMILES NC(=O)c1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C18H12F3N5O2/c19-18(20,21)8-26-14-5-13(9-3-1-2-4-10(9)16(22)27)23-6-11(14)15-12(17(26)28)7-24-25-15/h1-7H,8H2,(H2,22,27)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.02E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM364264
PNG
(US9856257, 49)
Show SMILES COc1ncc(Cl)cc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H11ClF3N5O2/c1-28-15-10(3-9(18)5-23-15)8-2-12-14(22-4-8)13-11(6-24-25-13)16(27)26(12)7-17(19,20)21/h2-6H,7H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.09E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir...


US Patent US9856257 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%