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Patent code US9862711

Compile Data Set for Download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364540
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)C1=CC(CN2CCOCC2)[S]=C1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H32N4O4S2/c1-18-2-7-23(36(32,33)29-20-3-5-21(31)6-4-20)13-24(18)26-15-27-14-25(28-26)19-12-22(35-17-19)16-30-8-10-34-11-9-30/h2,7,12-15,17,20-21,29,31H,3-6,8-11,16H2,1H3/t20-,21-
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n/an/a 6n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364540
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)C1=CC(CN2CCOCC2)[S]=C1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H32N4O4S2/c1-18-2-7-23(36(32,33)29-20-3-5-21(31)6-4-20)13-24(18)26-15-27-14-25(28-26)19-12-22(35-17-19)16-30-8-10-34-11-9-30/h2,7,12-15,17,20-21,29,31H,3-6,8-11,16H2,1H3/t20-,21-
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n/an/a 10n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364537
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[1-(2-m...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cnn(CCN2CCOCC2)c1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C25H34N6O4S/c1-19-4-5-21(36(33,34)28-7-6-25(2,3)32)14-22(19)24-17-26-16-23(29-24)20-15-27-31(18-20)9-8-30-10-12-35-13-11-30/h4-5,14-18,28,32H,6-13H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364535
PNG
(Cis 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-9-15-6-16(27)7-15)8-18(13)20-10-22-11-21(24-20)19-12-26(3)25-14(19)2/h4-5,8,10-12,15-16,23,27H,6-7,9H2,1-3H3/t15-,16+
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n/an/a 11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364534
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H27N5O3S/c1-14-4-5-18(32(30,31)27-16-7-23(8-16)9-17(29)10-23)6-19(14)21-11-24-12-22(25-21)20-13-28(3)26-15(20)2/h4-6,11-13,16-17,27,29H,7-10H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364532
PNG
(Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H25N5O3S/c1-14-5-6-16(30(27,28)23-11-21(3)12-29-13-21)7-17(14)19-8-22-9-20(24-19)18-10-26(4)25-15(18)2/h5-10,23H,11-13H2,1-4H3
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n/an/a 14n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364533
PNG
(Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-met...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C21H24N4O3S2/c1-13-3-8-17(30(27,28)25-15-4-6-16(26)7-5-15)9-18(13)19-10-22-11-20(24-19)21-12-23-14(2)29-21/h3,8-12,15-16,25-26H,4-7H2,1-2H3/t15-,16-
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n/an/a 15n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364530
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-6-7-15(29(27,28)22-12-20(3,4)26)8-16(13)18-9-21-10-19(23-18)17-11-25(5)24-14(17)2/h6-11,22,26H,12H2,1-5H3
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n/an/a 19n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364538
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-meth...)
Show SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C26H36N6O4S/c1-19-5-6-21(37(34,35)28-8-7-26(3,4)33)15-22(19)24-16-27-17-25(29-24)23-18-32(30-20(23)2)10-9-31-11-13-36-14-12-31/h5-6,15-18,28,33H,7-14H2,1-4H3
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n/an/a 20n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364536
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-12-21(3,4)13-27)8-17(14)19-9-22-10-20(24-19)18-11-26(5)25-15(18)2/h6-11,23,27H,12-13H2,1-5H3
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n/an/a 20n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364529
PNG
(N-(3-Hydroxy-propyl)-4-methyl-3-[6-(2-methyl-thiaz...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-12-4-5-14(27(24,25)21-6-3-7-23)8-15(12)16-9-19-10-17(22-16)18-11-20-13(2)26-18/h4-5,8-11,21,23H,3,6-7H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364538
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-meth...)
Show SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C26H36N6O4S/c1-19-5-6-21(37(34,35)28-8-7-26(3,4)33)15-22(19)24-16-27-17-25(29-24)23-18-32(30-20(23)2)10-9-31-11-13-36-14-12-31/h5-6,15-18,28,33H,7-14H2,1-4H3
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n/an/a 27n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364541
PNG
(Cis 3-[6-(2,5-Dimethyl-2H-pyrazol-3-yl)-pyrazin-2-...)
Show SMILES Cc1cc(-c2cncc(n2)-c2cc(ccc2C)S(=O)(=O)NC[C@@H]2C[C@H](O)C2)n(C)n1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-10-15-7-16(27)8-15)9-18(13)19-11-22-12-20(24-19)21-6-14(2)25-26(21)3/h4-6,9,11-12,15-16,23,27H,7-8,10H2,1-3H3/t15-,16+
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n/an/a 38n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364541
PNG
(Cis 3-[6-(2,5-Dimethyl-2H-pyrazol-3-yl)-pyrazin-2-...)
Show SMILES Cc1cc(-c2cncc(n2)-c2cc(ccc2C)S(=O)(=O)NC[C@@H]2C[C@H](O)C2)n(C)n1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-10-15-7-16(27)8-15)9-18(13)19-11-22-12-20(24-19)21-6-14(2)25-26(21)3/h4-6,9,11-12,15-16,23,27H,7-8,10H2,1-3H3/t15-,16+
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n/an/a 40n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364534
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H27N5O3S/c1-14-4-5-18(32(30,31)27-16-7-23(8-16)9-17(29)10-23)6-19(14)21-11-24-12-22(25-21)20-13-28(3)26-15(20)2/h4-6,11-13,16-17,27,29H,7-10H2,1-3H3
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n/an/a 40n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364531
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-9-8-21(3,4)27)10-17(14)19-11-22-12-20(24-19)18-13-26(5)25-15(18)2/h6-7,10-13,23,27H,8-9H2,1-5H3
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n/an/a 48n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364530
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-6-7-15(29(27,28)22-12-20(3,4)26)8-16(13)18-9-21-10-19(23-18)17-11-25(5)24-14(17)2/h6-11,22,26H,12H2,1-5H3
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n/an/a 50n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364536
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-12-21(3,4)13-27)8-17(14)19-9-22-10-20(24-19)18-11-26(5)25-15(18)2/h6-11,23,27H,12-13H2,1-5H3
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n/an/a 60n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364530
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-6-7-15(29(27,28)22-12-20(3,4)26)8-16(13)18-9-21-10-19(23-18)17-11-25(5)24-14(17)2/h6-11,22,26H,12H2,1-5H3
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n/an/a 60n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364532
PNG
(Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H25N5O3S/c1-14-5-6-16(30(27,28)23-11-21(3)12-29-13-21)7-17(14)19-8-22-9-20(24-19)18-10-26(4)25-15(18)2/h5-10,23H,11-13H2,1-4H3
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n/an/a 60n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364531
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-9-8-21(3,4)27)10-17(14)19-11-22-12-20(24-19)18-13-26(5)25-15(18)2/h6-7,10-13,23,27H,8-9H2,1-5H3
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n/an/a 70n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364536
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-12-21(3,4)13-27)8-17(14)19-9-22-10-20(24-19)18-11-26(5)25-15(18)2/h6-11,23,27H,12-13H2,1-5H3
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n/an/a 70n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364538
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-meth...)
Show SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C26H36N6O4S/c1-19-5-6-21(37(34,35)28-8-7-26(3,4)33)15-22(19)24-16-27-17-25(29-24)23-18-32(30-20(23)2)10-9-31-11-13-36-14-12-31/h5-6,15-18,28,33H,7-14H2,1-4H3
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n/an/a 70n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364532
PNG
(Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H25N5O3S/c1-14-5-6-16(30(27,28)23-11-21(3)12-29-13-21)7-17(14)19-8-22-9-20(24-19)18-10-26(4)25-15(18)2/h5-10,23H,11-13H2,1-4H3
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n/an/a 70n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364531
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-9-8-21(3,4)27)10-17(14)19-11-22-12-20(24-19)18-13-26(5)25-15(18)2/h6-7,10-13,23,27H,8-9H2,1-5H3
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n/an/a 80n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364539
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-(6-pyrid...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cccnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C22H24N4O3S/c1-15-4-9-19(30(28,29)26-17-5-7-18(27)8-6-17)11-20(15)22-14-24-13-21(25-22)16-3-2-10-23-12-16/h2-4,9-14,17-18,26-27H,5-8H2,1H3/t17-,18-
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n/an/a 88n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364534
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H27N5O3S/c1-14-4-5-18(32(30,31)27-16-7-23(8-16)9-17(29)10-23)6-19(14)21-11-24-12-22(25-21)20-13-28(3)26-15(20)2/h4-6,11-13,16-17,27,29H,7-10H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364533
PNG
(Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-met...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C21H24N4O3S2/c1-13-3-8-17(30(27,28)25-15-4-6-16(26)7-5-15)9-18(13)19-10-22-11-20(24-19)21-12-23-14(2)29-21/h3,8-12,15-16,25-26H,4-7H2,1-2H3/t15-,16-
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364535
PNG
(Cis 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-9-15-6-16(27)7-15)8-18(13)20-10-22-11-21(24-20)19-12-26(3)25-14(19)2/h4-5,8,10-12,15-16,23,27H,6-7,9H2,1-3H3/t15-,16+
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364541
PNG
(Cis 3-[6-(2,5-Dimethyl-2H-pyrazol-3-yl)-pyrazin-2-...)
Show SMILES Cc1cc(-c2cncc(n2)-c2cc(ccc2C)S(=O)(=O)NC[C@@H]2C[C@H](O)C2)n(C)n1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-10-15-7-16(27)8-15)9-18(13)19-11-22-12-20(24-19)21-6-14(2)25-26(21)3/h4-6,9,11-12,15-16,23,27H,7-8,10H2,1-3H3/t15-,16+
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364535
PNG
(Cis 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-9-15-6-16(27)7-15)8-18(13)20-10-22-11-21(24-20)19-12-26(3)25-14(19)2/h4-5,8,10-12,15-16,23,27H,6-7,9H2,1-3H3/t15-,16+
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364539
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-(6-pyrid...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cccnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C22H24N4O3S/c1-15-4-9-19(30(28,29)26-17-5-7-18(27)8-6-17)11-20(15)22-14-24-13-21(25-22)16-3-2-10-23-12-16/h2-4,9-14,17-18,26-27H,5-8H2,1H3/t17-,18-
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n/an/a 120n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364533
PNG
(Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-met...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C21H24N4O3S2/c1-13-3-8-17(30(27,28)25-15-4-6-16(26)7-5-15)9-18(13)19-10-22-11-20(24-19)21-12-23-14(2)29-21/h3,8-12,15-16,25-26H,4-7H2,1-2H3/t15-,16-
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n/an/a 150n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364540
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)C1=CC(CN2CCOCC2)[S]=C1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H32N4O4S2/c1-18-2-7-23(36(32,33)29-20-3-5-21(31)6-4-20)13-24(18)26-15-27-14-25(28-26)19-12-22(35-17-19)16-30-8-10-34-11-9-30/h2,7,12-15,17,20-21,29,31H,3-6,8-11,16H2,1H3/t20-,21-
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364537
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[1-(2-m...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cnn(CCN2CCOCC2)c1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C25H34N6O4S/c1-19-4-5-21(36(33,34)28-7-6-25(2,3)32)14-22(19)24-17-26-16-23(29-24)20-15-27-31(18-20)9-8-30-10-12-35-13-11-30/h4-5,14-18,28,32H,6-13H2,1-3H3
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n/an/a 160n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364529
PNG
(N-(3-Hydroxy-propyl)-4-methyl-3-[6-(2-methyl-thiaz...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-12-4-5-14(27(24,25)21-6-3-7-23)8-15(12)16-9-19-10-17(22-16)18-11-20-13(2)26-18/h4-5,8-11,21,23H,3,6-7H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM364529
PNG
(N-(3-Hydroxy-propyl)-4-methyl-3-[6-(2-methyl-thiaz...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-12-4-5-14(27(24,25)21-6-3-7-23)8-15(12)16-9-19-10-17(22-16)18-11-20-13(2)26-18/h4-5,8-11,21,23H,3,6-7H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364537
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[1-(2-m...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cnn(CCN2CCOCC2)c1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C25H34N6O4S/c1-19-4-5-21(36(33,34)28-7-6-25(2,3)32)14-22(19)24-17-26-16-23(29-24)20-15-27-31(18-20)9-8-30-10-12-35-13-11-30/h4-5,14-18,28,32H,6-13H2,1-3H3
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n/an/a 260n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM364539
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-(6-pyrid...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cccnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C22H24N4O3S/c1-15-4-9-19(30(28,29)26-17-5-7-18(27)8-6-17)11-20(15)22-14-24-13-21(25-22)16-3-2-10-23-12-16/h2-4,9-14,17-18,26-27H,5-8H2,1H3/t17-,18-
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n/an/a 400n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364534
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H27N5O3S/c1-14-4-5-18(32(30,31)27-16-7-23(8-16)9-17(29)10-23)6-19(14)21-11-24-12-22(25-21)20-13-28(3)26-15(20)2/h4-6,11-13,16-17,27,29H,7-10H2,1-3H3
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n/an/a 450n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364535
PNG
(Cis 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-9-15-6-16(27)7-15)8-18(13)20-10-22-11-21(24-20)19-12-26(3)25-14(19)2/h4-5,8,10-12,15-16,23,27H,6-7,9H2,1-3H3/t15-,16+
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n/an/a 630n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364536
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-12-21(3,4)13-27)8-17(14)19-9-22-10-20(24-19)18-11-26(5)25-15(18)2/h6-11,23,27H,12-13H2,1-5H3
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n/an/a 680n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364532
PNG
(Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H25N5O3S/c1-14-5-6-16(30(27,28)23-11-21(3)12-29-13-21)7-17(14)19-8-22-9-20(24-19)18-10-26(4)25-15(18)2/h5-10,23H,11-13H2,1-4H3
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n/an/a 680n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364530
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-6-7-15(29(27,28)22-12-20(3,4)26)8-16(13)18-9-21-10-19(23-18)17-11-25(5)24-14(17)2/h6-11,22,26H,12H2,1-5H3
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n/an/a 710n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364534
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H27N5O3S/c1-14-4-5-18(32(30,31)27-16-7-23(8-16)9-17(29)10-23)6-19(14)21-11-24-12-22(25-21)20-13-28(3)26-15(20)2/h4-6,11-13,16-17,27,29H,7-10H2,1-3H3
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n/an/a 770n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364532
PNG
(Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H25N5O3S/c1-14-5-6-16(30(27,28)23-11-21(3)12-29-13-21)7-17(14)19-8-22-9-20(24-19)18-10-26(4)25-15(18)2/h5-10,23H,11-13H2,1-4H3
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n/an/a 890n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364533
PNG
(Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-met...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C21H24N4O3S2/c1-13-3-8-17(30(27,28)25-15-4-6-16(26)7-5-15)9-18(13)19-10-22-11-20(24-19)21-12-23-14(2)29-21/h3,8-12,15-16,25-26H,4-7H2,1-2H3/t15-,16-
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n/an/a 1.12E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364530
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-6-7-15(29(27,28)22-12-20(3,4)26)8-16(13)18-9-21-10-19(23-18)17-11-25(5)24-14(17)2/h6-11,22,26H,12H2,1-5H3
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n/an/a 1.18E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364531
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-9-8-21(3,4)27)10-17(14)19-11-22-12-20(24-19)18-13-26(5)25-15(18)2/h6-7,10-13,23,27H,8-9H2,1-5H3
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n/an/a 1.45E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364533
PNG
(Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-met...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C21H24N4O3S2/c1-13-3-8-17(30(27,28)25-15-4-6-16(26)7-5-15)9-18(13)19-10-22-11-20(24-19)21-12-23-14(2)29-21/h3,8-12,15-16,25-26H,4-7H2,1-2H3/t15-,16-
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n/an/a 1.81E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364541
PNG
(Cis 3-[6-(2,5-Dimethyl-2H-pyrazol-3-yl)-pyrazin-2-...)
Show SMILES Cc1cc(-c2cncc(n2)-c2cc(ccc2C)S(=O)(=O)NC[C@@H]2C[C@H](O)C2)n(C)n1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-10-15-7-16(27)8-15)9-18(13)19-11-22-12-20(24-19)21-6-14(2)25-26(21)3/h4-6,9,11-12,15-16,23,27H,7-8,10H2,1-3H3/t15-,16+
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n/an/a 1.90E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364536
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-12-21(3,4)13-27)8-17(14)19-9-22-10-20(24-19)18-11-26(5)25-15(18)2/h6-11,23,27H,12-13H2,1-5H3
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n/an/a 1.95E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364541
PNG
(Cis 3-[6-(2,5-Dimethyl-2H-pyrazol-3-yl)-pyrazin-2-...)
Show SMILES Cc1cc(-c2cncc(n2)-c2cc(ccc2C)S(=O)(=O)NC[C@@H]2C[C@H](O)C2)n(C)n1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-10-15-7-16(27)8-15)9-18(13)19-11-22-12-20(24-19)21-6-14(2)25-26(21)3/h4-6,9,11-12,15-16,23,27H,7-8,10H2,1-3H3/t15-,16+
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n/an/a 2.45E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364541
PNG
(Cis 3-[6-(2,5-Dimethyl-2H-pyrazol-3-yl)-pyrazin-2-...)
Show SMILES Cc1cc(-c2cncc(n2)-c2cc(ccc2C)S(=O)(=O)NC[C@@H]2C[C@H](O)C2)n(C)n1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-10-15-7-16(27)8-15)9-18(13)19-11-22-12-20(24-19)21-6-14(2)25-26(21)3/h4-6,9,11-12,15-16,23,27H,7-8,10H2,1-3H3/t15-,16+
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n/an/a 3.00E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364529
PNG
(N-(3-Hydroxy-propyl)-4-methyl-3-[6-(2-methyl-thiaz...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-12-4-5-14(27(24,25)21-6-3-7-23)8-15(12)16-9-19-10-17(22-16)18-11-20-13(2)26-18/h4-5,8-11,21,23H,3,6-7H2,1-2H3
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n/an/a 3.07E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364539
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-(6-pyrid...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cccnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C22H24N4O3S/c1-15-4-9-19(30(28,29)26-17-5-7-18(27)8-6-17)11-20(15)22-14-24-13-21(25-22)16-3-2-10-23-12-16/h2-4,9-14,17-18,26-27H,5-8H2,1H3/t17-,18-
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n/an/a 3.08E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364530
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-6-7-15(29(27,28)22-12-20(3,4)26)8-16(13)18-9-21-10-19(23-18)17-11-25(5)24-14(17)2/h6-11,22,26H,12H2,1-5H3
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n/an/a 3.45E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364531
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-9-8-21(3,4)27)10-17(14)19-11-22-12-20(24-19)18-13-26(5)25-15(18)2/h6-7,10-13,23,27H,8-9H2,1-5H3
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n/an/a 3.85E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364539
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-(6-pyrid...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cccnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C22H24N4O3S/c1-15-4-9-19(30(28,29)26-17-5-7-18(27)8-6-17)11-20(15)22-14-24-13-21(25-22)16-3-2-10-23-12-16/h2-4,9-14,17-18,26-27H,5-8H2,1H3/t17-,18-
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n/an/a 3.93E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364532
PNG
(Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H25N5O3S/c1-14-5-6-16(30(27,28)23-11-21(3)12-29-13-21)7-17(14)19-8-22-9-20(24-19)18-10-26(4)25-15(18)2/h5-10,23H,11-13H2,1-4H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364535
PNG
(Cis 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-9-15-6-16(27)7-15)8-18(13)20-10-22-11-21(24-20)19-12-26(3)25-14(19)2/h4-5,8,10-12,15-16,23,27H,6-7,9H2,1-3H3/t15-,16+
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n/an/a 4.40E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364536
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-12-21(3,4)13-27)8-17(14)19-9-22-10-20(24-19)18-11-26(5)25-15(18)2/h6-11,23,27H,12-13H2,1-5H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364533
PNG
(Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-met...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C21H24N4O3S2/c1-13-3-8-17(30(27,28)25-15-4-6-16(26)7-5-15)9-18(13)19-10-22-11-20(24-19)21-12-23-14(2)29-21/h3,8-12,15-16,25-26H,4-7H2,1-2H3/t15-,16-
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n/an/a 4.77E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364529
PNG
(N-(3-Hydroxy-propyl)-4-methyl-3-[6-(2-methyl-thiaz...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-12-4-5-14(27(24,25)21-6-3-7-23)8-15(12)16-9-19-10-17(22-16)18-11-20-13(2)26-18/h4-5,8-11,21,23H,3,6-7H2,1-2H3
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n/an/a 5.25E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364531
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-9-8-21(3,4)27)10-17(14)19-11-22-12-20(24-19)18-13-26(5)25-15(18)2/h6-7,10-13,23,27H,8-9H2,1-5H3
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n/an/a 5.30E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364535
PNG
(Cis 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-9-15-6-16(27)7-15)8-18(13)20-10-22-11-21(24-20)19-12-26(3)25-14(19)2/h4-5,8,10-12,15-16,23,27H,6-7,9H2,1-3H3/t15-,16+
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n/an/a 6.00E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364529
PNG
(N-(3-Hydroxy-propyl)-4-methyl-3-[6-(2-methyl-thiaz...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-12-4-5-14(27(24,25)21-6-3-7-23)8-15(12)16-9-19-10-17(22-16)18-11-20-13(2)26-18/h4-5,8-11,21,23H,3,6-7H2,1-2H3
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n/an/a 6.16E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364539
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-(6-pyrid...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cccnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C22H24N4O3S/c1-15-4-9-19(30(28,29)26-17-5-7-18(27)8-6-17)11-20(15)22-14-24-13-21(25-22)16-3-2-10-23-12-16/h2-4,9-14,17-18,26-27H,5-8H2,1H3/t17-,18-
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n/an/a 6.24E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364538
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-meth...)
Show SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C26H36N6O4S/c1-19-5-6-21(37(34,35)28-8-7-26(3,4)33)15-22(19)24-16-27-17-25(29-24)23-18-32(30-20(23)2)10-9-31-11-13-36-14-12-31/h5-6,15-18,28,33H,7-14H2,1-4H3
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n/an/a 8.50E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364540
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)C1=CC(CN2CCOCC2)[S]=C1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H32N4O4S2/c1-18-2-7-23(36(32,33)29-20-3-5-21(31)6-4-20)13-24(18)26-15-27-14-25(28-26)19-12-22(35-17-19)16-30-8-10-34-11-9-30/h2,7,12-15,17,20-21,29,31H,3-6,8-11,16H2,1H3/t20-,21-
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n/an/a 8.60E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364540
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)C1=CC(CN2CCOCC2)[S]=C1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H32N4O4S2/c1-18-2-7-23(36(32,33)29-20-3-5-21(31)6-4-20)13-24(18)26-15-27-14-25(28-26)19-12-22(35-17-19)16-30-8-10-34-11-9-30/h2,7,12-15,17,20-21,29,31H,3-6,8-11,16H2,1H3/t20-,21-
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364540
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)C1=CC(CN2CCOCC2)[S]=C1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H32N4O4S2/c1-18-2-7-23(36(32,33)29-20-3-5-21(31)6-4-20)13-24(18)26-15-27-14-25(28-26)19-12-22(35-17-19)16-30-8-10-34-11-9-30/h2,7,12-15,17,20-21,29,31H,3-6,8-11,16H2,1H3/t20-,21-
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364537
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[1-(2-m...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cnn(CCN2CCOCC2)c1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C25H34N6O4S/c1-19-4-5-21(36(33,34)28-7-6-25(2,3)32)14-22(19)24-17-26-16-23(29-24)20-15-27-31(18-20)9-8-30-10-12-35-13-11-30/h4-5,14-18,28,32H,6-13H2,1-3H3
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364537
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[1-(2-m...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cnn(CCN2CCOCC2)c1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C25H34N6O4S/c1-19-4-5-21(36(33,34)28-7-6-25(2,3)32)14-22(19)24-17-26-16-23(29-24)20-15-27-31(18-20)9-8-30-10-12-35-13-11-30/h4-5,14-18,28,32H,6-13H2,1-3H3
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364539
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-(6-pyrid...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cccnc1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C22H24N4O3S/c1-15-4-9-19(30(28,29)26-17-5-7-18(27)8-6-17)11-20(15)22-14-24-13-21(25-22)16-3-2-10-23-12-16/h2-4,9-14,17-18,26-27H,5-8H2,1H3/t17-,18-
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364533
PNG
(Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-met...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C21H24N4O3S2/c1-13-3-8-17(30(27,28)25-15-4-6-16(26)7-5-15)9-18(13)19-10-22-11-20(24-19)21-12-23-14(2)29-21/h3,8-12,15-16,25-26H,4-7H2,1-2H3/t15-,16-
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364537
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[1-(2-m...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cnn(CCN2CCOCC2)c1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C25H34N6O4S/c1-19-4-5-21(36(33,34)28-7-6-25(2,3)32)14-22(19)24-17-26-16-23(29-24)20-15-27-31(18-20)9-8-30-10-12-35-13-11-30/h4-5,14-18,28,32H,6-13H2,1-3H3
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM364537
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[1-(2-m...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)-c1cnn(CCN2CCOCC2)c1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C25H34N6O4S/c1-19-4-5-21(36(33,34)28-7-6-25(2,3)32)14-22(19)24-17-26-16-23(29-24)20-15-27-31(18-20)9-8-30-10-12-35-13-11-30/h4-5,14-18,28,32H,6-13H2,1-3H3
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364529
PNG
(N-(3-Hydroxy-propyl)-4-methyl-3-[6-(2-methyl-thiaz...)
Show SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-12-4-5-14(27(24,25)21-6-3-7-23)8-15(12)16-9-19-10-17(22-16)18-11-20-13(2)26-18/h4-5,8-11,21,23H,3,6-7H2,1-2H3
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364540
PNG
(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Show SMILES Cc1ccc(cc1-c1cncc(n1)C1=CC(CN2CCOCC2)[S]=C1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1/C26H32N4O4S2/c1-18-2-7-23(36(32,33)29-20-3-5-21(31)6-4-20)13-24(18)26-15-27-14-25(28-26)19-12-22(35-17-19)16-30-8-10-34-11-9-30/h2,7,12-15,17,20-21,29,31H,3-6,8-11,16H2,1H3/t20-,21-
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n/an/a>9.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364534
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H27N5O3S/c1-14-4-5-18(32(30,31)27-16-7-23(8-16)9-17(29)10-23)6-19(14)21-11-24-12-22(25-21)20-13-28(3)26-15(20)2/h4-6,11-13,16-17,27,29H,7-10H2,1-3H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364541
PNG
(Cis 3-[6-(2,5-Dimethyl-2H-pyrazol-3-yl)-pyrazin-2-...)
Show SMILES Cc1cc(-c2cncc(n2)-c2cc(ccc2C)S(=O)(=O)NC[C@@H]2C[C@H](O)C2)n(C)n1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-10-15-7-16(27)8-15)9-18(13)19-11-22-12-20(24-19)21-6-14(2)25-26(21)3/h4-6,9,11-12,15-16,23,27H,7-8,10H2,1-3H3/t15-,16+
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n/an/a>9.55E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364536
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-12-21(3,4)13-27)8-17(14)19-9-22-10-20(24-19)18-11-26(5)25-15(18)2/h6-11,23,27H,12-13H2,1-5H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364531
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H27N5O3S/c1-14-6-7-16(30(28,29)23-9-8-21(3,4)27)10-17(14)19-11-22-12-20(24-19)18-13-26(5)25-15(18)2/h6-7,10-13,23,27H,8-9H2,1-5H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364530
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-6-7-15(29(27,28)22-12-20(3,4)26)8-16(13)18-9-21-10-19(23-18)17-11-25(5)24-14(17)2/h6-11,22,26H,12H2,1-5H3
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n/an/a>9.78E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM364538
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-meth...)
Show SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C26H36N6O4S/c1-19-5-6-21(37(34,35)28-8-7-26(3,4)33)15-22(19)24-16-27-17-25(29-24)23-18-32(30-20(23)2)10-9-31-11-13-36-14-12-31/h5-6,15-18,28,33H,7-14H2,1-4H3
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n/an/a 9.80E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor® 647-labeled, ATP-competitive kinase inhibitors to the kinase of int...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364534
PNG
(3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H27N5O3S/c1-14-4-5-18(32(30,31)27-16-7-23(8-16)9-17(29)10-23)6-19(14)21-11-24-12-22(25-21)20-13-28(3)26-15(20)2/h4-6,11-13,16-17,27,29H,7-10H2,1-3H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM364538
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-meth...)
Show SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C26H36N6O4S/c1-19-5-6-21(37(34,35)28-8-7-26(3,4)33)15-22(19)24-16-27-17-25(29-24)23-18-32(30-20(23)2)10-9-31-11-13-36-14-12-31/h5-6,15-18,28,33H,7-14H2,1-4H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364535
PNG
(Cis 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1/C21H25N5O3S/c1-13-4-5-17(30(28,29)23-9-15-6-16(27)7-15)8-18(13)20-10-22-11-21(24-20)19-12-26(3)25-14(19)2/h4-5,8,10-12,15-16,23,27H,6-7,9H2,1-3H3/t15-,16+
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n/an/a>1.00E+4n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364532
PNG
(Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-...)
Show SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H25N5O3S/c1-14-5-6-16(30(27,28)23-11-21(3)12-29-13-21)7-17(14)19-8-22-9-20(24-19)18-10-26(4)25-15(18)2/h5-10,23H,11-13H2,1-4H3
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NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta


(Homo sapiens (Human))
BDBM364538
PNG
(N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-meth...)
Show SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C26H36N6O4S/c1-19-5-6-21(37(34,35)28-8-7-26(3,4)33)15-22(19)24-16-27-17-25(29-24)23-18-32(30-20(23)2)10-9-31-11-13-36-14-12-31/h5-6,15-18,28,33H,7-14H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...


US Patent US9862711 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%