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Patent code US9862730

Compile Data Set for Download or QSAR

Found 405 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364891
PNG
(US9862730, Example 349)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(Cl)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22ClN3O5S/c1-33-21-11-24(36-16-18-6-4-8-20(10-18)35-15-17-5-3-7-19(29)9-17)22-13-26(37-25(22)12-21)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364941
PNG
(US9862730, Example 399)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4csc(C)n4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H22N4O5S2/c1-15-27-17(14-36-15)13-33-18-6-4-5-16(7-18)12-34-22-8-19(31-2)9-23-20(22)10-24(35-23)21-11-30-25(28-21)37-26(29-30)32-3/h4-11,14H,12-13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.590n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364858
PNG
(US9862730, Example 314)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(F)c4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21F2N3O5S/c1-34-19-10-23(20-12-25(38-24(20)11-19)22-13-33-27(31-22)39-28(32-33)35-2)37-14-16-5-3-7-18(9-16)36-15-17-6-4-8-21(29)26(17)30/h3-13H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.720n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364931
PNG
(US9862730, Example 389)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(OC)c(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N3O7S/c1-34-21-12-25(22-14-27(40-26(22)13-21)23-15-33-29(31-23)41-30(32-33)37-4)39-17-18-6-5-7-20(10-18)38-16-19-8-9-24(35-2)28(11-19)36-3/h5-15H,16-17H2,1-4H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.730n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364892
PNG
(US9862730, Example 350)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(F)cc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22FN3O5S/c1-33-20-11-24(36-16-18-8-19(29)10-21(9-18)35-15-17-6-4-3-5-7-17)22-13-26(37-25(22)12-20)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.760n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364945
PNG
(US9862730, Example 403)
Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2nc(oc2c1)-c1cn2nc(SC)sc2n1
Show InChI InChI=1S/C27H22N4O4S2/c1-32-20-12-22(34-16-18-9-6-10-19(11-18)33-15-17-7-4-3-5-8-17)24-23(13-20)35-25(29-24)21-14-31-26(28-21)37-27(30-31)36-2/h3-14H,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.860n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364882
PNG
((R)-6-(4-((2,2-Dimethyl-1,3-dioxolan-4-yl)methoxy)...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3COC(C)(C)O3)cc(OC)cc2o1
Show InChI InChI=1/C20H21N3O6S/c1-20(2)27-10-12(29-20)9-26-15-5-11(24-3)6-16-13(15)7-17(28-16)14-8-23-18(21-14)30-19(22-23)25-4/h5-8,12H,9-10H2,1-4H3/t12-/s2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.870n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364887
PNG
(US9862730, Example 345)
Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(oc2c1)-c1cn2nc(SC)sc2n1
Show InChI InChI=1S/C28H23N3O4S2/c1-32-21-12-24(34-17-19-9-6-10-20(11-19)33-16-18-7-4-3-5-8-18)22-14-26(35-25(22)13-21)23-15-31-27(29-23)37-28(30-31)36-2/h3-15H,16-17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.970n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364615
PNG
(US9862730, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC)cc(OC)cc2o1
Show InChI InChI=1S/C15H13N3O4S/c1-19-8-4-11(20-2)9-6-13(22-12(9)5-8)10-7-18-14(16-10)23-15(17-18)21-3/h4-7H,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.990n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364957
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-(difluoromethoxy...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC(F)F)cc2o1
Show InChI InChI=1S/C28H21F2N3O5S/c1-34-28-32-33-14-22(31-27(33)39-28)25-13-21-23(11-20(37-26(29)30)12-24(21)38-25)36-16-18-8-5-9-19(10-18)35-15-17-6-3-2-4-7-17/h2-14,26H,15-16H2,1H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.09n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364922
PNG
(US9862730, Example 380)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(OC)c(OC)c(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H29N3O8S/c1-35-21-12-24(22-14-26(42-25(22)13-21)23-15-34-30(32-23)43-31(33-34)39-5)41-16-18-7-6-8-20(9-18)40-17-19-10-27(36-2)29(38-4)28(11-19)37-3/h6-15H,16-17H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.11n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364949
PNG
(US9862730, Example 407)
Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1/C29H24FN3O4S/c1-18(30)28-32-33-15-24(31-29(33)38-28)27-14-23-25(12-22(34-2)13-26(23)37-27)36-17-20-9-6-10-21(11-20)35-16-19-7-4-3-5-8-19/h3-15,18H,16-17H2,1-2H3/t18-/s2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.12n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364886
PNG
(US9862730, Example 344)
Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(oc2c1)-c1cn2nc(Br)sc2n1
Show InChI InChI=1S/C27H20BrN3O4S/c1-32-20-11-23(34-16-18-8-5-9-19(10-18)33-15-17-6-3-2-4-7-17)21-13-25(35-24(21)12-20)22-14-31-27(29-22)36-26(28)30-31/h2-14H,15-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.12n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364613
PNG
(US9862730, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccc(OC)cc2o1
Show InChI InChI=1S/C14H11N3O3S/c1-18-9-4-3-8-5-12(20-11(8)6-9)10-7-17-13(15-10)21-14(16-17)19-2/h3-7H,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.22n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364853
PNG
(US9862730, Example 309)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O6S/c1-33-21-12-25(22-14-27(38-26(22)13-21)23-15-32-28(30-23)39-29(31-32)35-3)37-16-18-7-6-9-20(11-18)36-17-19-8-4-5-10-24(19)34-2/h4-15H,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.22n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364772
PNG
(US9862730, Example 229)
Show SMILES COc1cc(OC)c2cc(oc2c1)-c1cn2nc(SC)sc2n1
Show InChI InChI=1S/C15H13N3O3S2/c1-19-8-4-11(20-2)9-6-13(21-12(9)5-8)10-7-18-14(16-10)23-15(17-18)22-3/h4-7H,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.22n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364904
PNG
(US9862730, Example 362)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22ClN3O5S/c1-33-20-11-24(36-15-17-6-5-8-19(10-17)35-16-18-7-3-4-9-22(18)29)21-13-26(37-25(21)12-20)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.24n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364943
PNG
(US9862730, Example 401)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(Cl)cc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H24ClN3O6S/c1-34-21-9-18(7-19(30)10-21)16-37-20-6-4-5-17(8-20)15-38-25-11-22(35-2)12-26-23(25)13-27(39-26)24-14-33-28(31-24)40-29(32-33)36-3/h4-14H,15-16H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.28n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364903
PNG
(US9862730, Example 361)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(OC)c(OC)c4Cl)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H26ClN3O7S/c1-35-20-11-24(21-13-26(41-25(21)12-20)22-14-34-29(32-22)42-30(33-34)38-4)40-15-17-6-5-7-19(10-17)39-16-18-8-9-23(36-2)28(37-3)27(18)31/h5-14H,15-16H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.35n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364934
PNG
(US9862730, Example 392)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(OC)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O6S/c1-33-20-9-7-18(8-10-20)16-36-21-6-4-5-19(11-21)17-37-25-12-22(34-2)13-26-23(25)14-27(38-26)24-15-32-28(30-24)39-29(31-32)35-3/h4-15H,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.44n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364867
PNG
(US9862730, Example 323)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(Cl)cc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21ClFN3O5S/c1-34-20-10-24(21-12-26(38-25(21)11-20)23-13-33-27(31-23)39-28(32-33)35-2)37-14-16-4-3-5-19(8-16)36-15-17-6-7-18(29)9-22(17)30/h3-13H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.48n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364932
PNG
(US9862730, Example 390)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(OC)cc(OC)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N3O7S/c1-34-21-9-19(10-22(11-21)35-2)17-38-20-7-5-6-18(8-20)16-39-26-12-23(36-3)13-27-24(26)14-28(40-27)25-15-33-29(31-25)41-30(32-33)37-4/h5-15H,16-17H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364869
PNG
(US9862730, Example 325)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(F)c(F)c4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N3O5S/c1-35-18-9-22(19-11-24(39-23(19)10-18)21-12-34-27(32-21)40-28(33-34)36-2)38-13-15-4-3-5-17(8-15)37-14-16-6-7-20(29)26(31)25(16)30/h3-12H,13-14H2,1-2H3
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n/an/a 1.64n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364897
PNG
(US9862730, Example 355)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OC(=O)c4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21N3O6S/c1-33-20-12-23(35-16-17-7-6-10-19(11-17)36-26(32)18-8-4-3-5-9-18)21-14-25(37-24(21)13-20)22-15-31-27(29-22)38-28(30-31)34-2/h3-15H,16H2,1-2H3
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n/an/a 1.65n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364898
PNG
(US9862730, Example 356)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(F)cc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21F4N3O5S/c1-37-21-10-24(22-12-26(41-25(22)11-21)23-13-36-27(34-23)42-28(35-36)38-2)40-14-16-4-3-5-20(8-16)39-15-17-6-18(29(31,32)33)9-19(30)7-17/h3-13H,14-15H2,1-2H3
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n/an/a 1.66n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364924
PNG
(US9862730, Example 382)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cc(C)cc(C)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N3O5S/c1-18-8-19(2)10-21(9-18)17-36-22-7-5-6-20(11-22)16-37-26-12-23(34-3)13-27-24(26)14-28(38-27)25-15-33-29(31-25)39-30(32-33)35-4/h5-15H,16-17H2,1-4H3
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n/an/a 1.67n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364888
PNG
(US9862730, Example 346)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(F)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22FN3O5S/c1-33-21-11-24(36-16-18-4-3-5-20(10-18)35-15-17-6-8-19(29)9-7-17)22-13-26(37-25(22)12-21)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364928
PNG
(US9862730, Example 386)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(C)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O5S/c1-18-6-4-7-19(10-18)16-35-21-9-5-8-20(11-21)17-36-25-12-22(33-2)13-26-23(25)14-27(37-26)24-15-32-28(30-24)38-29(31-32)34-3/h4-15H,16-17H2,1-3H3
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n/an/a 1.77n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364954
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)benzofuran-2-yl)-2-...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cccc2o1
Show InChI InChI=1S/C27H21N3O4S/c1-31-27-29-30-15-22(28-26(30)35-27)25-14-21-23(11-6-12-24(21)34-25)33-17-19-9-5-10-20(13-19)32-16-18-7-3-2-4-8-18/h2-15H,16-17H2,1H3
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n/an/a 1.82n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364968
PNG
(US9862730, Example 427)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(F)cc2o1
Show InChI InChI=1S/C27H20FN3O4S/c1-32-27-30-31-14-22(29-26(31)36-27)25-13-21-23(11-19(28)12-24(21)35-25)34-16-18-8-5-9-20(10-18)33-15-17-6-3-2-4-7-17/h2-14H,15-16H2,1H3
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n/an/a 1.91n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364862
PNG
(US9862730, Example 318)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22FN3O5S/c1-33-20-11-24(36-15-17-6-5-8-19(10-17)35-16-18-7-3-4-9-22(18)29)21-13-26(37-25(21)12-20)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3
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n/an/a 1.92n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364747
PNG
(6-(4-Ethoxy, 6-methoxybenzofuran-2-yl)-2-(methylth...)
Show SMILES CCOc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1
Show InChI InChI=1S/C16H15N3O4S/c1-4-22-12-5-9(20-2)6-13-10(12)7-14(23-13)11-8-19-15(17-11)24-16(18-19)21-3/h5-8H,4H2,1-3H3
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n/an/a 2.01n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364896
PNG
(US9862730, Example 354)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(Br)cc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21BrFN3O5S/c1-34-20-10-24(21-12-26(38-25(21)11-20)23-13-33-27(31-23)39-28(32-33)35-2)37-14-16-4-3-5-19(8-16)36-15-17-6-7-18(29)9-22(17)30/h3-13H,14-15H2,1-2H3
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n/an/a 2.06n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364857
PNG
(US9862730, Example 313)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(cc4)C(C)C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C31H29N3O5S/c1-19(2)22-10-8-20(9-11-22)17-37-23-7-5-6-21(12-23)18-38-27-13-24(35-3)14-28-25(27)15-29(39-28)26-16-34-30(32-26)40-31(33-34)36-4/h5-16,19H,17-18H2,1-4H3
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n/an/a 2.11n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364856
PNG
(US9862730, Example 312)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(C)cc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N3O5S/c1-18-8-9-21(19(2)10-18)17-36-22-7-5-6-20(11-22)16-37-26-12-23(34-3)13-27-24(26)14-28(38-27)25-15-33-29(31-25)39-30(32-33)35-4/h5-15H,16-17H2,1-4H3
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n/an/a 2.13n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364940
PNG
(US9862730, Example 398)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccnc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S/c1-32-20-10-23(35-15-17-5-3-7-19(9-17)34-16-18-6-4-8-28-13-18)21-12-25(36-24(21)11-20)22-14-31-26(29-22)37-27(30-31)33-2/h3-14H,15-16H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364883
PNG
(US9862730, Example 340)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3C(=O)OC(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1/C24H28N4O6S/c1-24(2,3)34-23(29)27-8-6-7-14(27)13-32-18-9-15(30-4)10-19-16(18)11-20(33-19)17-12-28-21(25-17)35-22(26-28)31-5/h9-12,14H,6-8,13H2,1-5H3/t14-/s2
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n/an/a 2.21n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364893
PNG
(US9862730, Example 351)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccc(OC)c(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O6S/c1-33-20-12-24(21-14-26(38-25(21)13-20)22-15-32-28(30-22)39-29(31-32)35-3)36-17-19-9-10-23(34-2)27(11-19)37-16-18-7-5-4-6-8-18/h4-15H,16-17H2,1-3H3
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n/an/a 2.23n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364895
PNG
(US9862730, Example 353)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(OC)c4OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N3O7S/c1-34-21-12-25(22-14-27(40-26(22)13-21)23-15-33-29(31-23)41-30(32-33)37-4)39-16-18-7-5-9-20(11-18)38-17-19-8-6-10-24(35-2)28(19)36-3/h5-15H,16-17H2,1-4H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364890
PNG
(US9862730, Example 348)
Show SMILES CCOc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O5S/c1-3-34-29-31-32-16-24(30-28(32)38-29)27-15-23-25(13-22(33-2)14-26(23)37-27)36-18-20-10-7-11-21(12-20)35-17-19-8-5-4-6-9-19/h4-16H,3,17-18H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364914
PNG
(US9862730, Example 372)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(Oc5ccccc5)cc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C34H27N3O6S/c1-38-27-16-30(28-18-32(43-31(28)17-27)29-19-37-33(35-29)44-34(36-37)39-2)41-21-23-7-6-10-26(15-23)40-20-22-11-13-25(14-12-22)42-24-8-4-3-5-9-24/h3-19H,20-21H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364939
PNG
(US9862730, Example 397)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(NC(=O)c5ccccc5)c4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C35H28N4O6S/c1-41-27-16-30(28-18-32(45-31(28)17-27)29-19-39-34(37-29)46-35(38-39)42-2)44-21-23-9-7-13-26(15-23)43-20-22-8-6-12-25(14-22)36-33(40)24-10-4-3-5-11-24/h3-19H,20-21H2,1-2H3,(H,36,40)
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364916
PNG
(US9862730, Example 374)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccc(F)cc4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21F2N3O5S/c1-34-20-10-24(21-12-26(38-25(21)11-20)23-13-33-27(31-23)39-28(32-33)35-2)37-14-16-4-3-5-19(8-16)36-15-17-6-7-18(29)9-22(17)30/h3-13H,14-15H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364746
PNG
(6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofura...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364905
PNG
(US9862730, Example 363)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O5S/c1-18-7-4-5-9-20(18)17-35-21-10-6-8-19(11-21)16-36-25-12-22(33-2)13-26-23(25)14-27(37-26)24-15-32-28(30-24)38-29(31-32)34-3/h4-15H,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.42n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364946
PNG
(US9862730, Example 404)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(OC)cc(OCc4ccccc4)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O6S/c1-33-20-9-19(10-22(11-20)36-16-18-7-5-4-6-8-18)17-37-25-12-21(34-2)13-26-23(25)14-27(38-26)24-15-32-28(30-24)39-29(31-32)35-3/h4-15H,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.44n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364902
PNG
(US9862730, Example 360)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4ccccc4Br)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H22BrN3O5S/c1-33-20-11-24(36-15-17-6-5-8-19(10-17)35-16-18-7-3-4-9-22(18)29)21-13-26(37-25(21)12-20)23-14-32-27(30-23)38-28(31-32)34-2/h3-14H,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.47n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364900
PNG
(US9862730, Example 358)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cccc(c4)C(F)(F)F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H22F3N3O5S/c1-36-21-11-24(22-13-26(40-25(22)12-21)23-14-35-27(33-23)41-28(34-35)37-2)39-16-18-6-4-8-20(10-18)38-15-17-5-3-7-19(9-17)29(30,31)32/h3-14H,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.54n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364873
PNG
(US9862730, Example 330)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4c(F)ccc(F)c4F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N3O5S/c1-35-17-9-23(18-11-25(39-24(18)10-17)22-12-34-27(32-22)40-28(33-34)36-2)38-13-15-4-3-5-16(8-15)37-14-19-20(29)6-7-21(30)26(19)31/h3-12H,13-14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.62n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364889
PNG
(US9862730, Example 347)
Show SMILES COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(oc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C29H23F2N3O4S/c1-29(30,31)27-33-34-15-23(32-28(34)39-27)26-14-22-24(12-21(35-2)13-25(22)38-26)37-17-19-9-6-10-20(11-19)36-16-18-7-4-3-5-8-18/h3-15H,16-17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.74n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)

More data for this
Ligand-Target Pair
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