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Patent code US9867833

Compile Data Set for Download or QSAR
Found 197 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365084
PNG
(9-(4-chlorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccc(Cl)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C26H23ClN8O/c1-33-24-14-18(17-7-9-28-21(12-17)30-22-8-10-29-34(22)2)13-23-31-32-26(35(23)24)19(15-25(33)36)11-16-3-5-20(27)6-4-16/h3-10,12-14,19H,11,15H2,1-2H3,(H,28,30)
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n/an/a<0.0200n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365102
PNG
(4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-ox...)
Show SMILES COc1ccc(C[C@@H]2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1F
Show InChI InChI=1/C25H22FN7O2/c1-32-22(6-8-28-32)29-21-11-16(5-7-27-21)17-12-23-30-31-25-18(14-35-24(13-17)33(23)25)9-15-3-4-20(34-2)19(26)10-15/h3-8,10-13,18H,9,14H2,1-2H3,(H,27,29)/t18-/s2
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n/an/a<0.0200n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365109
PNG
(4-(3-(3,4-difluorobenzyl)-3,4- dihydro-5-oxa-1,2,2...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@@H](Cc3ccc(F)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H18F2N8O/c1-32-19(5-7-27-32)29-23-26-6-4-18(28-23)14-10-20-30-31-22-15(12-34-21(11-14)33(20)22)8-13-2-3-16(24)17(25)9-13/h2-7,9-11,15H,8,12H2,1H3,(H,26,28,29)/t15-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365135
PNG
(4-(9-(4-fluorophenoxy)- 8,9-dihydro-7H-6-oxa- 1,2,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Oc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19FN8O2/c1-31-19(7-10-26-31)28-23-25-9-6-17(27-23)14-12-20-29-30-22-18(8-11-33-21(13-14)32(20)22)34-16-4-2-15(24)3-5-16/h2-7,9-10,12-13,18H,8,11H2,1H3,(H,25,27,28)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365148
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Cn3cc(cn3)C(F)(F)F)c3nnc(c1)n23
Show InChI InChI=1/C22H19F3N10O/c1-33-17(3-6-27-33)30-21-26-5-2-16(29-21)14-8-18-31-32-20-13(4-7-36-19(9-14)35(18)20)11-34-12-15(10-28-34)22(23,24)25/h2-3,5-6,8-10,12-13H,4,7,11H2,1H3,(H,26,29,30)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365161
PNG
(4-(3-(3-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...)
Show SMILES COc1cccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)c1
Show InChI InChI=1/C24H22N8O2/c1-31-20(7-9-26-31)28-24-25-8-6-19(27-24)16-12-21-29-30-23-17(14-34-22(13-16)32(21)23)10-15-4-3-5-18(11-15)33-2/h3-9,11-13,17H,10,14H2,1-2H3,(H,25,27,28)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365209
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-methylthiaz...)
Show SMILES Cc1csc(C[C@@H]2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)n1
Show InChI InChI=1/C22H21N9OS/c1-13-12-33-19(25-13)10-14-5-8-32-20-11-15(9-18-28-29-21(14)31(18)20)16-3-6-23-22(26-16)27-17-4-7-24-30(17)2/h3-4,6-7,9,11-12,14H,5,8,10H2,1-2H3,(H,23,26,27)/t14-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365210
PNG
(4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihyd...)
Show SMILES Clc1cnn(C[C@@H]2CCOc3cc(cc4nnc2n34)-c2ccnc(NC3CCOCC3)n2)c1
Show InChI InChI=1/C22H23ClN8O2/c23-16-11-25-30(13-16)12-14-2-8-33-20-10-15(9-19-28-29-21(14)31(19)20)18-1-5-24-22(27-18)26-17-3-6-32-7-4-17/h1,5,9-11,13-14,17H,2-4,6-8,12H2,(H,24,26,27)/t14-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365212
PNG
(4-(9-(3,4-difluorophenoxy)- 8,9-dihydro-7H-6-oxa- ...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Oc3ccc(F)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H18F2N8O2/c1-32-19(5-8-27-32)29-23-26-7-4-17(28-23)13-10-20-30-31-22-18(6-9-34-21(11-13)33(20)22)35-14-2-3-15(24)16(25)12-14/h2-5,7-8,10-12,18H,6,9H2,1H3,(H,26,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365023
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@H](Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H21N9/c1-31-19(8-10-26-31)28-23-24-9-7-18(27-23)16-12-20-25-14-17(11-15-5-3-2-4-6-15)22-30-29-21(13-16)32(20)22/h2-10,12-13,17,25H,11,14H2,1H3,(H,24,27,28)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365075
PNG
(4-(3-(4-chloro-3- fluorobenzyl)-5-methyl-4,5- dihy...)
Show SMILES CN1CC(Cc2ccc(Cl)c(F)c2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H21ClFN9/c1-33-13-16(9-14-3-4-17(25)18(26)10-14)23-32-31-21-11-15(12-22(33)35(21)23)19-5-7-27-24(29-19)30-20-6-8-28-34(20)2/h3-8,10-12,16H,9,13H2,1-2H3,(H,27,29,30)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365115
PNG
(4-(9-((4-cyclopropyl-1H- pyrazol-1-yl)methyl)-8,9-...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Cn3cc(cn3)C3CC3)c3nnc(c1)n23
Show InChI InChI=1/C24H24N10O/c1-32-20(5-8-26-32)29-24-25-7-4-19(28-24)17-10-21-30-31-23-16(6-9-35-22(11-17)34(21)23)13-33-14-18(12-27-33)15-2-3-15/h4-5,7-8,10-12,14-16H,2-3,6,9,13H2,1H3,(H,25,28,29)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365167
PNG
(9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-m...)
Show SMILES COc1ccc(C[C@@H]2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)c(F)c1
Show InChI InChI=1/C26H24FN9O2/c1-34-23-12-16(20-6-8-28-26(30-20)31-21-7-9-29-35(21)2)11-22-32-33-25(36(22)23)17(13-24(34)37)10-15-4-5-18(38-3)14-19(15)27/h4-9,11-12,14,17H,10,13H2,1-3H3,(H,28,30,31)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365175
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC[C@@H](Cn3cc(cn3)C(F)(F)F)c3nnc(c1)n23
Show InChI InChI=1/C23H20F3N9O/c1-33-19(3-6-28-33)30-18-8-14(2-5-27-18)16-9-20-31-32-22-15(4-7-36-21(10-16)35(20)22)12-34-13-17(11-29-34)23(24,25)26/h2-3,5-6,8-11,13,15H,4,7,12H2,1H3,(H,27,30)/t15-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365081
PNG
(4-(3-benzyl-3,4-dihydro-5- oxa-1,2,2a1- triazaacen...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OC[C@@H](Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C24H21N7O/c1-30-21(8-10-26-30)27-20-12-17(7-9-25-20)18-13-22-28-29-24-19(11-16-5-3-2-4-6-16)15-32-23(14-18)31(22)24/h2-10,12-14,19H,11,15H2,1H3,(H,25,27)/t19-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365086
PNG
(4-(3-(4-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@@H](Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClN8O/c1-31-19(7-9-26-31)28-23-25-8-6-18(27-23)15-11-20-29-30-22-16(13-33-21(12-15)32(20)22)10-14-2-4-17(24)5-3-14/h2-9,11-12,16H,10,13H2,1H3,(H,25,27,28)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365098
PNG
(4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihyd...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC[C@@H](Cn3cc(Cl)cn3)c3nnc(c1)n23
Show InChI InChI=1/C22H20ClN9O/c1-30-19(3-6-25-30)27-18-8-14(2-5-24-18)16-9-20-28-29-22-15(12-31-13-17(23)11-26-31)4-7-33-21(10-16)32(20)22/h2-3,5-6,8-11,13,15H,4,7,12H2,1H3,(H,24,27)/t15-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365104
PNG
(4-(3-(4-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...)
Show SMILES COc1ccc(C[C@@H]2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1/C24H22N8O2/c1-31-20(8-10-26-31)28-24-25-9-7-19(27-24)16-12-21-29-30-23-17(14-34-22(13-16)32(21)23)11-15-3-5-18(33-2)6-4-15/h3-10,12-13,17H,11,14H2,1-2H3,(H,25,27,28)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365117
PNG
(4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OC[C@@H](Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H20FN7O/c1-31-21(7-9-27-31)28-20-11-16(6-8-26-20)17-12-22-29-30-24-18(14-33-23(13-17)32(22)24)10-15-2-4-19(25)5-3-15/h2-9,11-13,18H,10,14H2,1H3,(H,26,28)/t18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365184
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((3-methylisoxa...)
Show SMILES Cc1cc(C[C@@H]2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)on1
Show InChI InChI=1/C22H21N9O2/c1-13-9-16(33-29-13)10-14-5-8-32-20-12-15(11-19-27-28-21(14)31(19)20)17-3-6-23-22(25-17)26-18-4-7-24-30(18)2/h3-4,6-7,9,11-12,14H,5,8,10H2,1-2H3,(H,23,25,26)/t14-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365201
PNG
((S)-2-[4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyr...)
Show SMILES CCC(C#N)C1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H21N9O/c1-3-13(12-22)15-6-9-31-19-11-14(10-18-27-28-20(15)30(18)19)16-4-7-23-21(25-16)26-17-5-8-24-29(17)2/h4-5,7-8,10-11,13,15H,3,6,9H2,1-2H3,(H,23,25,26)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365034
PNG
(4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- te...)
Show SMILES CN1C[C@H](Cc2ccccc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H23N9/c1-31-15-18(12-16-6-4-3-5-7-16)23-30-29-21-13-17(14-22(31)33(21)23)19-8-10-25-24(27-19)28-20-9-11-26-32(20)2/h3-11,13-14,18H,12,15H2,1-2H3,(H,25,27,28)/t18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365040
PNG
(4-(3-(3-fluoro-4- methoxybenzyl)-4,5-dihydro- 3H-1...)
Show SMILES COc1ccc(C[C@H]2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F
Show InChI InChI=1/C24H22FN9O/c1-33-20(6-8-28-33)30-24-26-7-5-18(29-24)15-11-21-27-13-16(23-32-31-22(12-15)34(21)23)9-14-3-4-19(35-2)17(25)10-14/h3-8,10-12,16,27H,9,13H2,1-2H3,(H,26,29,30)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365044
PNG
(4-(3-(4-chloro-3- fluorobenzyl)-4,5-dihydro- 3H-1,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NCC(Cc3ccc(Cl)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClFN9/c1-33-19(5-7-28-33)30-23-26-6-4-18(29-23)14-10-20-27-12-15(22-32-31-21(11-14)34(20)22)8-13-2-3-16(24)17(25)9-13/h2-7,9-11,15,27H,8,12H2,1H3,(H,26,29,30)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365048
PNG
(4-(3-benzyl-3,4-dihydro-5- thia-1,2,2a1- triazaace...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2SC[C@@H](Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20N8S/c1-30-19(8-10-25-30)27-23-24-9-7-18(26-23)16-12-20-28-29-22-17(11-15-5-3-2-4-6-15)14-32-21(13-16)31(20)22/h2-10,12-13,17H,11,14H2,1H3,(H,24,26,27)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365062
PNG
(4-(3-((6-methoxypyridin-3- yl)methyl)-4,5-dihydro-...)
Show SMILES COc1ccc(CC2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cn1
Show InChI InChI=1/C23H22N10O/c1-32-18(6-8-27-32)29-23-24-7-5-17(28-23)15-10-19-25-13-16(22-31-30-20(11-15)33(19)22)9-14-3-4-21(34-2)26-12-14/h3-8,10-12,16,25H,9,13H2,1-2H3,(H,24,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365072
PNG
(4-(9-(2-chlorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCCC(Cc3ccccc3Cl)c3nnc(c1)n23
Show InChI InChI=1/C25H22ClN7O/c1-32-22(7-10-28-32)29-21-13-16(6-9-27-21)19-14-23-30-31-25-18(8-11-34-24(15-19)33(23)25)12-17-4-2-3-5-20(17)26/h2-7,9-10,13-15,18H,8,11-12H2,1H3,(H,27,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365153
PNG
(4-(3-benzyl-4-methyl-3,4- dihydro-5-oxa-1,2,2a1- t...)
Show SMILES C[C@@H]1Oc2cc(cc3nnc([C@@H]1Cc1ccccc1)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H22N8O/c1-15-18(12-16-6-4-3-5-7-16)23-30-29-21-13-17(14-22(33-15)32(21)23)19-8-10-25-24(27-19)28-20-9-11-26-31(20)2/h3-11,13-15,18H,12H2,1-2H3,(H,25,27,28)/t15-,18+/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365177
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-phenoxy-8,9- di...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Oc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20N8O2/c1-30-19(8-11-25-30)27-23-24-10-7-17(26-23)15-13-20-28-29-22-18(33-16-5-3-2-4-6-16)9-12-32-21(14-15)31(20)22/h2-8,10-11,13-14,18H,9,12H2,1H3,(H,24,26,27)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365192
PNG
(3-(3-chlorobenzyl)-5-methyl- 7-(2-((1-methyl-1H-py...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2nnc3n(Cc4cccc(Cl)c4)c(=O)n(C)c(c1)n23
Show InChI InChI=1S/C23H19ClN10O/c1-31-20-12-15(17-6-8-25-21(27-17)28-18-7-9-26-32(18)2)11-19-29-30-22(34(19)20)33(23(31)35)13-14-4-3-5-16(24)10-14/h3-12H,13H2,1-2H3,(H,25,27,28)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365027
PNG
(4-(3-(4-chlorobenzyl)-4,5- dihydro-3H-1,2,2a1,5- t...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@H](Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20ClN9/c1-32-19(7-9-27-32)29-23-25-8-6-18(28-23)15-11-20-26-13-16(10-14-2-4-17(24)5-3-14)22-31-30-21(12-15)33(20)22/h2-9,11-12,16,26H,10,13H2,1H3,(H,25,28,29)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365046
PNG
(4-(3-benzyl-3,4-dihydro-5- oxa-1,2,2a1- triazaacen...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@@H](Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20N8O/c1-30-19(8-10-25-30)27-23-24-9-7-18(26-23)16-12-20-28-29-22-17(11-15-5-3-2-4-6-15)14-32-21(13-16)31(20)22/h2-10,12-13,17H,11,14H2,1H3,(H,24,26,27)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365050
PNG
(4-(3-benzyl-5-ethyl-4,5- dihydro-3H-1,2,2a1,5- tet...)
Show SMILES CCN1CC(Cc2ccccc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H25N9/c1-3-33-16-19(13-17-7-5-4-6-8-17)24-31-30-22-14-18(15-23(33)34(22)24)20-9-11-26-25(28-20)29-21-10-12-27-32(21)2/h4-12,14-15,19H,3,13,16H2,1-2H3,(H,26,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365057
PNG
(4-(3-(4-fluorobenzyl)-4,5- dihydro-3H-1,2,2a1,5- t...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NCC(Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20FN9/c1-32-19(7-9-27-32)29-23-25-8-6-18(28-23)15-11-20-26-13-16(10-14-2-4-17(24)5-3-14)22-31-30-21(12-15)33(20)22/h2-9,11-12,16,26H,10,13H2,1H3,(H,25,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365100
PNG
(4-(3-(4-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OC[C@@H](Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H20ClN7O/c1-31-21(7-9-27-31)28-20-11-16(6-8-26-20)17-12-22-29-30-24-18(14-33-23(13-17)32(22)24)10-15-2-4-19(25)5-3-15/h2-9,11-13,18H,10,14H2,1H3,(H,26,28)/t18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365127
PNG
(9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-...)
Show SMILES COc1ccc(C[C@@H]2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1/C26H25N9O2/c1-33-23-14-17(20-8-10-27-26(29-20)30-21-9-11-28-34(21)2)13-22-31-32-25(35(22)23)18(15-24(33)36)12-16-4-6-19(37-3)7-5-16/h4-11,13-14,18H,12,15H2,1-3H3,(H,27,29,30)/t18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365188
PNG
(4-(3-(3-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...)
Show SMILES COc1cccc(C[C@@H]2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)c1
Show InChI InChI=1/C25H23N7O2/c1-31-22(7-9-27-31)28-21-12-17(6-8-26-21)18-13-23-29-30-25-19(15-34-24(14-18)32(23)25)10-16-4-3-5-20(11-16)33-2/h3-9,11-14,19H,10,15H2,1-2H3,(H,26,28)/t19-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365030
PNG
(4-(3-benzyl-4,5-dihydro-3H- 1,2,2a1,5- tetraazaace...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2NC[C@H](Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C24H22N8/c1-31-21(8-10-27-31)28-20-12-17(7-9-25-20)18-13-22-26-15-19(11-16-5-3-2-4-6-16)24-30-29-23(14-18)32(22)24/h2-10,12-14,19,26H,11,15H2,1H3,(H,25,28)/t19-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365032
PNG
(4-(3-(4-chlorobenzyl)-4,5- dihydro-3H-1,2,2a1,5- t...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2NC[C@H](Cc3ccc(Cl)cc3)c3ncc(c1)n23
Show InChI InChI=1/C25H22ClN7/c1-32-23(7-9-30-32)31-22-12-17(6-8-27-22)18-11-21-15-29-25-19(14-28-24(13-18)33(21)25)10-16-2-4-20(26)5-3-16/h2-9,11-13,15,19,28H,10,14H2,1H3,(H,27,31)/t19-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365078
PNG
(4-(9-(4-chlorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H21ClN8O/c1-32-20(7-10-27-32)29-24-26-9-6-19(28-24)17-13-21-30-31-23-16(8-11-34-22(14-17)33(21)23)12-15-2-4-18(25)5-3-15/h2-7,9-10,13-14,16H,8,11-12H2,1H3,(H,26,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365094
PNG
(4-(3-isobutyl-3,4-dihydro-5- oxa-1,2,2a1- triazaac...)
Show SMILES CC(C)C[C@@H]1COc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H22N8O/c1-12(2)8-14-11-29-18-10-13(9-17-25-26-19(14)28(17)18)15-4-6-21-20(23-15)24-16-5-7-22-27(16)3/h4-7,9-10,12,14H,8,11H2,1-3H3,(H,21,23,24)/t14-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365146
PNG
(4-(3-benzyl-4-methyl-3,4- dihydro-5-oxa-1,2,2a1- t...)
Show SMILES C[C@@H]1Oc2cc(cc3nnc([C@H]1Cc1ccccc1)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H22N8O/c1-15-18(12-16-6-4-3-5-7-16)23-30-29-21-13-17(14-22(33-15)32(21)23)19-8-10-25-24(27-19)28-20-9-11-26-31(20)2/h3-11,13-15,18H,12H2,1-2H3,(H,25,27,28)/t15-,18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365036
PNG
(4-(3-isobutyl-4,5-dihydro- 3H-1,2,2a1,5- tetraazaa...)
Show SMILES CC(C)C[C@H]1CNc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H23N9/c1-12(2)8-14-11-22-17-9-13(10-18-26-27-19(14)29(17)18)15-4-6-21-20(24-15)25-16-5-7-23-28(16)3/h4-7,9-10,12,14,22H,8,11H2,1-3H3,(H,21,24,25)/t14-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365042
PNG
(4-(3-(4-chlorobenzyl)-5- methyl-4,5-dihydro-3H- 1,...)
Show SMILES CN1CC(Cc2ccc(Cl)cc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C25H23ClN8/c1-32-15-19(11-16-3-5-20(26)6-4-16)25-31-30-23-13-18(14-24(32)34(23)25)17-7-9-27-21(12-17)29-22-8-10-28-33(22)2/h3-10,12-14,19H,11,15H2,1-2H3,(H,27,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365059
PNG
(9-(4-chlorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccc(Cl)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H22ClN9O/c1-33-22-13-16(19-7-9-27-25(29-19)30-20-8-10-28-34(20)2)12-21-31-32-24(35(21)22)17(14-23(33)36)11-15-3-5-18(26)6-4-15/h3-10,12-13,17H,11,14H2,1-2H3,(H,27,29,30)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365068
PNG
(3-benzyl-5-methyl-7-(2-((1- methyl-1H-pyrazol-5- y...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2nnc3n(Cc4ccccc4)c(=O)n(C)c(c1)n23
Show InChI InChI=1S/C23H20N10O/c1-30-20-13-16(17-8-10-24-21(26-17)27-18-9-11-25-31(18)2)12-19-28-29-22(33(19)20)32(23(30)34)14-15-6-4-3-5-7-15/h3-13H,14H2,1-2H3,(H,24,26,27)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365073
PNG
(4-(3-(4-fluorobenzyl)-5- methyl-4,5-dihydro-3H- 1,...)
Show SMILES CN1CC(Cc2ccc(F)cc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H22FN9/c1-32-14-17(11-15-3-5-18(25)6-4-15)23-31-30-21-12-16(13-22(32)34(21)23)19-7-9-26-24(28-19)29-20-8-10-27-33(20)2/h3-10,12-13,17H,11,14H2,1-2H3,(H,26,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365092
PNG
(4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1 -...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@@H](Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19FN8O/c1-31-19(7-9-26-31)28-23-25-8-6-18(27-23)15-11-20-29-30-22-16(13-33-21(12-15)32(20)22)10-14-2-4-17(24)5-3-14/h2-9,11-12,16H,10,13H2,1H3,(H,25,27,28)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365096
PNG
(4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-ox...)
Show SMILES COc1ccc(C[C@@H]2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F
Show InChI InChI=1/C24H21FN8O2/c1-32-20(6-8-27-32)29-24-26-7-5-18(28-24)15-11-21-30-31-23-16(13-35-22(12-15)33(21)23)9-14-3-4-19(34-2)17(25)10-14/h3-8,10-12,16H,9,13H2,1-2H3,(H,26,28,29)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365100
PNG
(4-(3-(4-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OC[C@@H](Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H20ClN7O/c1-31-21(7-9-27-31)28-20-11-16(6-8-26-20)17-12-22-29-30-24-18(14-33-23(13-17)32(22)24)10-15-2-4-19(25)5-3-15/h2-9,11-13,18H,10,14H2,1H3,(H,26,28)/t18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365119
PNG
(4-(9-(4-fluorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H21FN8O/c1-32-20(7-10-27-32)29-24-26-9-6-19(28-24)17-13-21-30-31-23-16(8-11-34-22(14-17)33(21)23)12-15-2-4-18(25)5-3-15/h2-7,9-10,13-14,16H,8,11-12H2,1H3,(H,26,28,29)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365129
PNG
(9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-...)
Show SMILES COc1ccc(C[C@@H]2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1
Show InChI InChI=1/C27H26N8O2/c1-33-25-15-19(18-8-10-28-22(13-18)30-23-9-11-29-34(23)2)14-24-31-32-27(35(24)25)20(16-26(33)36)12-17-4-6-21(37-3)7-5-17/h4-11,13-15,20H,12,16H2,1-3H3,(H,28,30)/t20-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365149
PNG
(9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-m...)
Show SMILES COc1ccc(C[C@@H]2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)c(F)c1
Show InChI InChI=1/C27H25FN8O2/c1-34-25-13-18(16-6-8-29-22(11-16)31-23-7-9-30-35(23)2)12-24-32-33-27(36(24)25)19(14-26(34)37)10-17-4-5-20(38-3)15-21(17)28/h4-9,11-13,15,19H,10,14H2,1-3H3,(H,29,31)/t19-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365174
PNG
(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@@H](Cc3cccc(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClN8O/c1-31-19(6-8-26-31)28-23-25-7-5-18(27-23)15-11-20-29-30-22-16(13-33-21(12-15)32(20)22)9-14-3-2-4-17(24)10-14/h2-8,10-12,16H,9,13H2,1H3,(H,25,27,28)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365200
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-propyl-8,9-dihy...)
Show SMILES CCCC1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H22N8O/c1-3-4-13-7-10-29-18-12-14(11-17-25-26-19(13)28(17)18)15-5-8-21-20(23-15)24-16-6-9-22-27(16)2/h5-6,8-9,11-13H,3-4,7,10H2,1-2H3,(H,21,23,24)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365135
PNG
(4-(9-(4-fluorophenoxy)- 8,9-dihydro-7H-6-oxa- 1,2,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Oc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19FN8O2/c1-31-19(7-10-26-31)28-23-25-9-6-17(27-23)14-12-20-29-30-22-18(8-11-33-21(13-14)32(20)22)34-16-4-2-15(24)3-5-16/h2-7,9-10,12-13,18H,8,11H2,1H3,(H,25,27,28)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365038
PNG
(4-(3-(4-methoxybenzyl)-4,5- dihydro-3H-1,2,2a1,5- ...)
Show SMILES COc1ccc(C[C@H]2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1/C24H23N9O/c1-32-20(8-10-27-32)29-24-25-9-7-19(28-24)16-12-21-26-14-17(23-31-30-22(13-16)33(21)23)11-15-3-5-18(34-2)6-4-15/h3-10,12-13,17,26H,11,14H2,1-2H3,(H,25,28,29)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365069
PNG
(4-(9-((benzyloxy)methyl)- 8,9-dihydro-7H-6-oxa- 1,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(COCc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C25H24N8O2/c1-32-21(8-11-27-32)29-25-26-10-7-20(28-25)19-13-22-30-31-24-18(9-12-35-23(14-19)33(22)24)16-34-15-17-5-3-2-4-6-17/h2-8,10-11,13-14,18H,9,12,15-16H2,1H3,(H,26,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365107
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-(2-methylbutyl)...)
Show SMILES CCC(C)CC1COc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H24N8O/c1-4-13(2)9-15-12-30-19-11-14(10-18-26-27-20(15)29(18)19)16-5-7-22-21(24-16)25-17-6-8-23-28(17)3/h5-8,10-11,13,15H,4,9,12H2,1-3H3,(H,22,24,25)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365121
PNG
(4-(9-(3-fluoro-4- methoxybenzyl)-8,9- dihydro-7H-6...)
Show SMILES COc1ccc(C[C@@H]2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F
Show InChI InChI=1/C25H23FN8O2/c1-33-21(6-9-28-33)30-25-27-8-5-19(29-25)17-13-22-31-32-24-16(7-10-36-23(14-17)34(22)24)11-15-3-4-20(35-2)18(26)12-15/h3-6,8-9,12-14,16H,7,10-11H2,1-2H3,(H,27,29,30)/t16-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365137
PNG
(9-benzyl-6-methyl-4-(2-((1- methyl-1H-pyrazol-5- y...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccccc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H23N9O/c1-32-22-14-17(19-8-10-26-25(28-19)29-20-9-11-27-33(20)2)13-21-30-31-24(34(21)22)18(15-23(32)35)12-16-6-4-3-5-7-16/h3-11,13-14,18H,12,15H2,1-2H3,(H,26,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365156
PNG
(4-(9-((5-chloropyridin-3- yl)oxy)-8,9-dihydro-7H-6...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Oc3cncc(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C22H18ClN9O2/c1-31-18(3-6-26-31)28-22-25-5-2-16(27-22)13-8-19-29-30-21-17(4-7-33-20(9-13)32(19)21)34-15-10-14(23)11-24-12-15/h2-3,5-6,8-12,17H,4,7H2,1H3,(H,25,27,28)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365158
PNG
(4-(9-((5-chloropyridin-3- yl)oxy)-8,9-dihydro-7H-6...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCCC(Oc3cncc(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClN8O2/c1-31-20(3-6-27-31)28-19-8-14(2-5-26-19)15-9-21-29-30-23-18(4-7-33-22(10-15)32(21)23)34-17-11-16(24)12-25-13-17/h2-3,5-6,8-13,18H,4,7H2,1H3,(H,26,28)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365160
PNG
((S)-9-(3-chlorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Show SMILES CN1c2cc(cc3nnc([C@@H](Cc4cccc(Cl)c4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H22ClN9O/c1-33-22-13-16(19-6-8-27-25(29-19)30-20-7-9-28-34(20)2)12-21-31-32-24(35(21)22)17(14-23(33)36)10-15-4-3-5-18(26)11-15/h3-9,11-13,17H,10,14H2,1-2H3,(H,27,29,30)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365025
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2NC[C@@H](c3nnc(c1)n23)c1ccccc1
Show InChI InChI=1/C23H20N8/c1-30-20(8-10-26-30)27-19-11-16(7-9-24-19)17-12-21-25-14-18(15-5-3-2-4-6-15)23-29-28-22(13-17)31(21)23/h2-13,18,25H,14H2,1H3,(H,24,27)/t18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365072
PNG
(4-(9-(2-chlorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCCC(Cc3ccccc3Cl)c3nnc(c1)n23
Show InChI InChI=1/C25H22ClN7O/c1-32-22(7-10-28-32)29-21-13-16(6-9-27-21)19-14-23-30-31-25-18(8-11-34-24(15-19)33(23)25)12-17-4-2-3-5-20(17)26/h2-7,9-10,13-15,18H,8,11-12H2,1H3,(H,27,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365029
PNG
((R)-9-4-chlorobenzyl)-6- methyl-4-(2-((1-methyl-1H...)
Show SMILES CN1c2cc(cc3nnc([C@@H](Cc4ccc(Cl)cc4)NC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H21ClN10O/c1-33-21-13-15(17-7-9-26-23(28-17)30-19-8-10-27-34(19)2)12-20-31-32-22(35(20)21)18(29-24(33)36)11-14-3-5-16(25)6-4-14/h3-10,12-13,18H,11H2,1-2H3,(H,29,36)(H,26,28,30)/t18-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365205
PNG
(4-(9-isobutyl-8,9-dihydro- 7H-6-oxa-1,2,2a1- triaz...)
Show SMILES CC(C)CC1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H24N8O/c1-13(2)10-14-6-9-30-19-12-15(11-18-26-27-20(14)29(18)19)16-4-7-22-21(24-16)25-17-5-8-23-28(17)3/h4-5,7-8,11-14H,6,9-10H2,1-3H3,(H,22,24,25)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365196
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(3,3,3- trifluo...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(CCC(F)(F)F)c3nnc(c1)n23
Show InChI InChI=1/C20H19F3N8O/c1-30-15(4-8-25-30)27-19-24-7-3-14(26-19)13-10-16-28-29-18-12(2-6-20(21,22)23)5-9-32-17(11-13)31(16)18/h3-4,7-8,10-12H,2,5-6,9H2,1H3,(H,24,26,27)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365198
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-propyl-8,9-dihy...)
Show SMILES CCCC1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C21H23N7O/c1-3-4-14-7-10-29-20-13-16(12-19-25-26-21(14)28(19)20)15-5-8-22-17(11-15)24-18-6-9-23-27(18)2/h5-6,8-9,11-14H,3-4,7,10H2,1-2H3,(H,22,24)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365066
PNG
(4-(3-((6-methoxypyridin-2- yl)methyl)-4,5-dihydro-...)
Show SMILES COc1cccc(CC2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)n1
Show InChI InChI=1/C23H22N10O/c1-32-18(7-9-26-32)29-23-24-8-6-17(28-23)14-11-19-25-13-15(22-31-30-20(12-14)33(19)22)10-16-4-3-5-21(27-16)34-2/h3-9,11-12,15,25H,10,13H2,1-2H3,(H,24,28,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365111
PNG
(4-(3-(3,4-difluorobenzyl)-3,4- dihydro-5-oxa-1,2,2...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OC[C@@H](Cc3ccc(F)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C24H19F2N7O/c1-32-21(5-7-28-32)29-20-10-15(4-6-27-20)16-11-22-30-31-24-17(13-34-23(12-16)33(22)24)8-14-2-3-18(25)19(26)9-14/h2-7,9-12,17H,8,13H2,1H3,(H,27,29)/t17-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365179
PNG
(4-(9-((5-fluoropyridin-3- yl)oxy)-8,9-dihydro-7H-6...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Oc3cncc(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C22H18FN9O2/c1-31-18(3-6-26-31)28-22-25-5-2-16(27-22)13-8-19-29-30-21-17(4-7-33-20(9-13)32(19)21)34-15-10-14(23)11-24-12-15/h2-3,5-6,8-12,17H,4,7H2,1H3,(H,25,27,28)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365052
PNG
(4-(3-(4-methoxybenzyl)-5- methyl-4,5-dihydro-3H- 1...)
Show SMILES COc1ccc(CC2CN(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1
Show InChI InChI=1/C26H26N8O/c1-32-16-20(12-17-4-6-21(35-3)7-5-17)26-31-30-24-14-19(15-25(32)34(24)26)18-8-10-27-22(13-18)29-23-9-11-28-33(23)2/h4-11,13-15,20H,12,16H2,1-3H3,(H,27,29)
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365194
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-propyl-3,4-dihy...)
Show SMILES CCC[C@@H]1COc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C19H20N8O/c1-3-4-12-11-28-17-10-13(9-16-24-25-18(12)27(16)17)14-5-7-20-19(22-14)23-15-6-8-21-26(15)2/h5-10,12H,3-4,11H2,1-2H3,(H,20,22,23)/t12-/s2
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GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365024
PNG
(S-4-(3-isopropyl-4,5-dihydro- 3H-1,2,2a1,5- tetraa...)
Show SMILES CC(C)[C@H]1CNc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C19H21N9/c1-11(2)13-10-21-16-8-12(9-17-25-26-18(13)28(16)17)14-4-6-20-19(23-14)24-15-5-7-22-27(15)3/h4-9,11,13,21H,10H2,1-3H3,(H,20,23,24)/t13-/s2
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n/an/a 0.0390n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365045
PNG
(4-(3-(4-chloro-3- fluorobenzyl)-4,5-dihydro- 3H-1,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@@H](Cc3ccc(Cl)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClFN9/c1-33-19(5-7-28-33)30-23-26-6-4-18(29-23)14-10-20-27-12-15(22-32-31-21(11-14)34(20)22)8-13-2-3-16(24)17(25)9-13/h2-7,9-11,15,27H,8,12H2,1H3,(H,26,29,30)/t15-/s2
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n/an/a 0.0440n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365125
PNG
(9-benzyl-6-methyl-4-(2- ((1-methyl-1H-pyrazol-5- y...)
Show SMILES CN1c2cc(cc3nnc([C@H](Cc4ccccc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C26H24N8O/c1-32-24-15-19(18-8-10-27-21(13-18)29-22-9-11-28-33(22)2)14-23-30-31-26(34(23)24)20(16-25(32)35)12-17-6-4-3-5-7-17/h3-11,13-15,20H,12,16H2,1-2H3,(H,27,29)/t20-/s2
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n/an/a 0.0730n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365088
PNG
(S-4-(9-((4-chloro-1H- pyrazol-1-yl)methyl)-8,9- di...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Cn3cc(Cl)cn3)c3nnc(c1)n23
Show InChI InChI=1/C21H19ClN10O/c1-30-17(3-6-24-30)27-21-23-5-2-16(26-21)14-8-18-28-29-20-13(11-31-12-15(22)10-25-31)4-7-33-19(9-14)32(18)20/h2-3,5-6,8-10,12-13H,4,7,11H2,1H3,(H,23,26,27)/t13-/s2
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n/an/a 0.0790n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365201
PNG
((S)-2-[4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyr...)
Show SMILES CCC(C#N)C1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H21N9O/c1-3-13(12-22)15-6-9-31-19-11-14(10-18-27-28-20(15)30(18)19)16-4-7-23-21(25-16)26-17-5-8-24-29(17)2/h4-5,7-8,10-11,13,15H,3,6,9H2,1-2H3,(H,23,25,26)
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n/an/a 0.0820n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365182
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((1-methyl-1H- ...)
Show SMILES Cn1nccc1CC1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C22H22N10O/c1-30-16(3-8-24-30)11-14-6-10-33-20-13-15(12-19-28-29-21(14)32(19)20)17-4-7-23-22(26-17)27-18-5-9-25-31(18)2/h3-5,7-9,12-14H,6,10-11H2,1-2H3,(H,23,26,27)
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n/an/a 0.0850n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365203
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(2,2,2-trifluor...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](CC(F)(F)F)c3nnc(c1)n23
Show InChI InChI=1/C19H17F3N8O/c1-29-14(3-6-24-29)26-18-23-5-2-13(25-18)12-8-15-27-28-17-11(10-19(20,21)22)4-7-31-16(9-12)30(15)17/h2-3,5-6,8-9,11H,4,7,10H2,1H3,(H,23,25,26)/t11-/s2
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n/an/a 0.0880n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365165
PNG
(9-((5-chloropyridin-2- yl)methyl)-6-methyl-4-(2-((...)
Show SMILES CN1c2cc(cc3nnc([C@H](Cc4ccc(Cl)cn4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H21ClN10O/c1-33-21-11-14(18-5-7-26-24(29-18)30-19-6-8-28-34(19)2)10-20-31-32-23(35(20)21)15(12-22(33)36)9-17-4-3-16(25)13-27-17/h3-8,10-11,13,15H,9,12H2,1-2H3,(H,26,29,30)/t15-/s2
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n/an/a 0.102n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365208
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-methylthiaz...)
Show SMILES Cc1csc(CC2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)n1
Show InChI InChI=1/C22H21N9OS/c1-13-12-33-19(25-13)10-14-5-8-32-20-11-15(9-18-28-29-21(14)31(18)20)16-3-6-23-22(26-16)27-17-4-7-24-30(17)2/h3-4,6-7,9,11-12,14H,5,8,10H2,1-2H3,(H,23,26,27)
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n/an/a 0.103n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365070
PNG
(4-(9-((benzyloxy)methyl)- 8,9-dihydro-7H-6-oxa- 1,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](COCc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C25H24N8O2/c1-32-21(8-11-27-32)29-25-26-10-7-20(28-25)19-13-22-30-31-24-18(9-12-35-23(14-19)33(22)24)16-34-15-17-5-3-2-4-6-17/h2-8,10-11,13-14,18H,9,12,15-16H2,1H3,(H,26,28,29)/t18-/s2
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n/an/a 0.109n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365164
PNG
(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccc(F)c(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C24H19ClFN7O/c1-32-21(5-7-28-32)29-20-10-15(4-6-27-20)16-11-22-30-31-24-17(13-34-23(12-16)33(22)24)8-14-2-3-19(26)18(25)9-14/h2-7,9-12,17H,8,13H2,1H3,(H,27,29)
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n/an/a 0.111n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365191
PNG
(3-(3,5-difluorobenzyl)-5- methyl-7-(2-((1-methyl-1...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2nnc3n(Cc4cc(F)cc(F)c4)c(=O)n(C)c(c1)n23
Show InChI InChI=1S/C23H18F2N10O/c1-32-20-10-14(17-3-5-26-21(28-17)29-18-4-6-27-33(18)2)9-19-30-31-22(35(19)20)34(23(32)36)12-13-7-15(24)11-16(25)8-13/h3-11H,12H2,1-2H3,(H,26,28,29)
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n/an/a 0.113n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365089
PNG
(S-4-(9-((4-chloro-1H- pyrazol-1-yl)methyl)-8,9- di...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Cn3cc(Cl)cn3)c3nnc(c1)n23
Show InChI InChI=1/C21H19ClN10O/c1-30-17(3-6-24-30)27-21-23-5-2-16(26-21)14-8-18-28-29-20-13(11-31-12-15(22)10-25-31)4-7-33-19(9-14)32(18)20/h2-3,5-6,8-10,12-13H,4,7,11H2,1H3,(H,23,26,27)
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n/an/a 0.131n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365138
PNG
(9-isobutyl-6-methyl-4-(2-((1- methyl-1H-pyrazol-5-...)
Show SMILES CC(C)C[C@@H]1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C22H25N9O/c1-13(2)9-15-12-20(32)29(3)19-11-14(10-18-27-28-21(15)31(18)19)16-5-7-23-22(25-16)26-17-6-8-24-30(17)4/h5-8,10-11,13,15H,9,12H2,1-4H3,(H,23,25,26)/t15-/s2
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n/an/a 0.132n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365211
PNG
(4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihyd...)
Show SMILES Clc1cnn(CC2CCOc3cc(cc4nnc2n34)-c2ccnc(NC3CCOCC3)n2)c1
Show InChI InChI=1/C22H23ClN8O2/c23-16-11-25-30(13-16)12-14-2-8-33-20-10-15(9-19-28-29-21(14)31(19)20)18-1-5-24-22(27-18)26-17-3-6-32-7-4-17/h1,5,9-11,13-14,17H,2-4,6-8,12H2,(H,24,26,27)
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n/an/a 0.140n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365131
PNG
(6-methyl-4-(2-((1-methyl- 1H-pyrazol-5- yl)amino)p...)
Show SMILES CCCC1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H23N9O/c1-4-5-13-12-19(31)28(2)18-11-14(10-17-26-27-20(13)30(17)18)15-6-8-22-21(24-15)25-16-7-9-23-29(16)3/h6-11,13H,4-5,12H2,1-3H3,(H,22,24,25)
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n/an/a 0.149n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365187
PNG
(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3cccc(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C24H20ClN7O/c1-31-21(6-8-27-31)28-20-11-16(5-7-26-20)17-12-22-29-30-24-18(14-33-23(13-17)32(22)24)9-15-3-2-4-19(25)10-15/h2-8,10-13,18H,9,14H2,1H3,(H,26,28)
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n/an/a 0.149n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365202
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(2,2,2-trifluor...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(CC(F)(F)F)c3nnc(c1)n23
Show InChI InChI=1/C19H17F3N8O/c1-29-14(3-6-24-29)26-18-23-5-2-13(25-18)12-8-15-27-28-17-11(10-19(20,21)22)4-7-31-16(9-12)30(15)17/h2-3,5-6,8-9,11H,4,7,10H2,1H3,(H,23,25,26)
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n/an/a 0.168n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365077
PNG
((R)-9-(4-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Show SMILES CN1c2cc(cc3nnc([C@@H](Cc4ccc(F)cc4)NC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H21FN10O/c1-33-21-13-15(17-7-9-26-23(28-17)30-19-8-10-27-34(19)2)12-20-31-32-22(35(20)21)18(29-24(33)36)11-14-3-5-16(25)6-4-14/h3-10,12-13,18H,11H2,1-2H3,(H,29,36)(H,26,28,30)/t18-/s2
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n/an/a 0.173n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365083
PNG
((R)-9-(3-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Show SMILES CN1c2cc(cc3nnc([C@@H](Cc4cccc(F)c4)NC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H21FN10O/c1-33-21-13-15(17-6-8-26-23(28-17)30-19-7-9-27-34(19)2)12-20-31-32-22(35(20)21)18(29-24(33)36)11-14-4-3-5-16(25)10-14/h3-10,12-13,18H,11H2,1-2H3,(H,29,36)(H,26,28,30)/t18-/s2
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n/an/a 0.215n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365190
PNG
(3-(4-chlorobenzyl)-5-methyl- 7-(2-((1-methyl-1H-py...)
Show SMILES CN\C(Nc1nccc(n1)-c1cc2n(C)c(=O)n(Cc3ccc(Cl)cc3)c(=N)n2c(=N)c1)=C/C=N
Show InChI InChI=1S/C23H23ClN10O/c1-28-19(7-9-25)31-22-29-10-8-17(30-22)15-11-18(26)34-20(12-15)32(2)23(35)33(21(34)27)13-14-3-5-16(24)6-4-14/h3-12,25-28H,13H2,1-2H3,(H,29,30,31)/b19-7+,25-9?,26-18?,27-21?
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n/an/a 0.273n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365120
PNG
(4-(9-(4-fluorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H21FN8O/c1-32-20(7-10-27-32)29-24-26-9-6-19(28-24)17-13-21-30-31-23-16(8-11-34-22(14-17)33(21)23)12-15-2-4-18(25)5-3-15/h2-7,9-10,13-14,16H,8,11-12H2,1H3,(H,26,28,29)
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n/an/a 0.311n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365041
PNG
(4-(3-(3-fluoro-4- methoxybenzyl)-4,5-dihydro- 3H-1...)
Show SMILES COc1ccc(C[C@@H]2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F
Show InChI InChI=1/C24H22FN9O/c1-33-20(6-8-28-33)30-24-26-7-5-18(29-24)15-11-21-27-13-16(23-32-31-22(12-15)34(21)23)9-14-3-4-19(35-2)17(25)10-14/h3-8,10-12,16,27H,9,13H2,1-2H3,(H,26,29,30)/t16-/s2
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n/an/a 0.311n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365155
PNG
(4-(9-((5-chloropyridin-3- yl)oxy)-8,9-dihydro-7H-6...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Oc3cncc(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C22H18ClN9O2/c1-31-18(3-6-26-31)28-22-25-5-2-16(27-22)13-8-19-29-30-21-17(4-7-33-20(9-13)32(19)21)34-15-10-14(23)11-24-12-15/h2-3,5-6,8-12,17H,4,7H2,1H3,(H,25,27,28)/t17-/s2
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n/an/a 0.311n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365142
PNG
(9-(4-fluorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CN1c2cc(cc3nnc([C@H](Cc4ccc(F)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C26H23FN8O/c1-33-24-14-18(17-7-9-28-21(12-17)30-22-8-10-29-34(22)2)13-23-31-32-26(35(23)24)19(15-25(33)36)11-16-3-5-20(27)6-4-16/h3-10,12-14,19H,11,15H2,1-2H3,(H,28,30)/t19-/s2
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n/an/a 0.316n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365055
PNG
(4-(3-isobutyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- ...)
Show SMILES CC(C)C[C@@H]1CN(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C22H26N8/c1-14(2)9-17-13-28(3)21-12-16(11-20-26-27-22(17)30(20)21)15-5-7-23-18(10-15)25-19-6-8-24-29(19)4/h5-8,10-12,14,17H,9,13H2,1-4H3,(H,23,25)/t17-/s2
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n/an/a 0.316n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365022
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@@H](Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H21N9/c1-31-19(8-10-26-31)28-23-24-9-7-18(27-23)16-12-20-25-14-17(11-15-5-3-2-4-6-15)22-30-29-21(13-16)32(20)22/h2-10,12-13,17,25H,11,14H2,1H3,(H,24,27,28)/t17-/s2
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n/an/a 0.380n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365065
PNG
((R)-9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl-...)
Show SMILES COc1ccc(C[C@H]2NC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1
Show InChI InChI=1/C26H25N9O2/c1-33-24-15-18(17-8-10-27-21(13-17)30-22-9-11-28-34(22)2)14-23-31-32-25(35(23)24)20(29-26(33)36)12-16-4-6-19(37-3)7-5-16/h4-11,13-15,20H,12H2,1-3H3,(H,27,30)(H,29,36)/t20-/s2
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n/an/a 0.390n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365028
PNG
(4-(3-(4-chlorobenzyl)-4,5- dihydro-3H-1,2,2a1,5- t...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@@H](Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20ClN9/c1-32-19(7-9-27-32)29-23-25-8-6-18(28-23)15-11-20-26-13-16(10-14-2-4-17(24)5-3-14)22-31-30-21(12-15)33(20)22/h2-9,11-12,16,26H,10,13H2,1H3,(H,25,28,29)/t16-/s2
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n/an/a 0.408n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365099
PNG
(4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihyd...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCCC(Cn3cc(Cl)cn3)c3nnc(c1)n23
Show InChI InChI=1/C22H20ClN9O/c1-30-19(3-6-25-30)27-18-8-14(2-5-24-18)16-9-20-28-29-22-15(12-31-13-17(23)11-26-31)4-7-33-21(10-16)32(20)22/h2-3,5-6,8-11,13,15H,4,7,12H2,1H3,(H,24,27)
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n/an/a 0.465n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365154
PNG
(4-(3-benzyl-4-methyl-3,4- dihydro-5-oxa-1,2,2a1- t...)
Show SMILES C[C@H]1Oc2cc(cc3nnc([C@H]1Cc1ccccc1)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H22N8O/c1-15-18(12-16-6-4-3-5-7-16)23-30-29-21-13-17(14-22(33-15)32(21)23)19-8-10-25-24(27-19)28-20-9-11-26-31(20)2/h3-11,13-15,18H,12H2,1-2H3,(H,25,27,28)/t15-,18+/s2
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n/an/a 0.470n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365140
PNG
(9-isopropyl-6-methyl-4-(2- ((1-methyl-1H-pyrazol-5...)
Show SMILES CC(C)[C@@H]1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H23N9O/c1-12(2)14-11-19(31)28(3)18-10-13(9-17-26-27-20(14)30(17)18)15-5-7-22-21(24-15)25-16-6-8-23-29(16)4/h5-10,12,14H,11H2,1-4H3,(H,22,24,25)/t14-/s2
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n/an/a 0.512n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365039
PNG
(4-(3-(4-methoxybenzyl)-4,5- dihydro-3H-1,2,2a1,5- ...)
Show SMILES COc1ccc(CC2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1/C24H23N9O/c1-32-20(8-10-27-32)29-24-25-9-7-19(28-24)16-12-21-26-14-17(23-31-30-22(13-16)33(21)23)11-15-3-5-18(34-2)6-4-15/h3-10,12-13,17,26H,11,14H2,1-2H3,(H,25,28,29)
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n/an/a 0.514n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365162
PNG
(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5- oxa...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@@H](Cc3ccc(F)c(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H18ClFN8O/c1-32-19(5-7-27-32)29-23-26-6-4-18(28-23)14-10-20-30-31-22-15(12-34-21(11-14)33(20)22)8-13-2-3-17(25)16(24)9-13/h2-7,9-11,15H,8,12H2,1H3,(H,26,28,29)/t15-/s2
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n/an/a 0.600n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365075
PNG
(4-(3-(4-chloro-3- fluorobenzyl)-5-methyl-4,5- dihy...)
Show SMILES CN1CC(Cc2ccc(Cl)c(F)c2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H21ClFN9/c1-33-13-16(9-14-3-4-17(25)18(26)10-14)23-32-31-21-11-15(12-22(33)35(21)23)19-5-7-27-24(29-19)30-20-6-8-28-34(20)2/h3-8,10-12,16H,9,13H2,1-2H3,(H,27,29,30)
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n/an/a 0.600n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365144
PNG
(6-methyl-4-(2-((1-methyl-1H- pyrazol-5- yl)amino)p...)
Show SMILES CN1c2cc(cc3nnc([C@H](CC(F)(F)F)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H18F3N9O/c1-30-16-8-11(13-3-5-24-19(26-13)27-14-4-6-25-31(14)2)7-15-28-29-18(32(15)16)12(9-17(30)33)10-20(21,22)23/h3-8,12H,9-10H2,1-2H3,(H,24,26,27)/t12-/s2
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n/an/a 0.655n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365133
PNG
(9-cyclopropyl-6-methyl- 4-(2-((1-methyl-1H- pyrazo...)
Show SMILES CN1c2cc(cc3nnc([C@@H](CC1=O)C1CC1)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H21N9O/c1-28-18-10-13(15-5-7-22-21(24-15)25-16-6-8-23-29(16)2)9-17-26-27-20(30(17)18)14(11-19(28)31)12-3-4-12/h5-10,12,14H,3-4,11H2,1-2H3,(H,22,24,25)/t14-/s2
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n/an/a 0.660n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365049
PNG
(4-(3-benzyl-3,4-dihydro-5- thia-1,2,2a1- triazaace...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2SCC(Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20N8S/c1-30-19(8-10-25-30)27-23-24-9-7-18(26-23)16-12-20-28-29-22-17(11-15-5-3-2-4-6-15)14-32-21(13-16)31(20)22/h2-10,12-13,17H,11,14H2,1H3,(H,24,26,27)
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n/an/a 0.661n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365079
PNG
(4-(9-(4-chlorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H21ClN8O/c1-32-20(7-10-27-32)29-24-26-9-6-19(28-24)17-13-21-30-31-23-16(8-11-34-22(14-17)33(21)23)12-15-2-4-18(25)5-3-15/h2-7,9-10,13-14,16H,8,11-12H2,1H3,(H,26,28,29)/t16-/s2
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n/an/a 0.690n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365031
PNG
(4-(3-benzyl-4,5-dihydro-3H- 1,2,2a1,5- tetraazaace...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2NC[C@@H](Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C24H22N8/c1-31-21(8-10-27-31)28-20-12-17(7-9-25-20)18-13-22-26-15-19(11-16-5-3-2-4-6-16)24-30-29-23(14-18)32(22)24/h2-10,12-14,19,26H,11,15H2,1H3,(H,25,28)/t19-/s2
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n/an/a 0.707n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365058
PNG
(4-(3-(4-fluorobenzyl)-4,5- dihydro-3H-1,2,2a1,5- t...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@@H](Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20FN9/c1-32-19(7-9-27-32)29-23-25-8-6-18(28-23)15-11-20-26-13-16(10-14-2-4-17(24)5-3-14)22-31-30-21(12-15)33(20)22/h2-9,11-12,16,26H,10,13H2,1H3,(H,25,28,29)/t16-/s2
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n/an/a 0.731n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365186
PNG
(4-(3-cyclopropyl-3,4- dihydro-5-oxa-1,2,2a1- triaz...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(C3CC3)c3nnc(c1)n23
Show InChI InChI=1/C19H18N8O/c1-26-15(5-7-21-26)23-19-20-6-4-14(22-19)12-8-16-24-25-18-13(11-2-3-11)10-28-17(9-12)27(16)18/h4-9,11,13H,2-3,10H2,1H3,(H,20,22,23)
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n/an/a 0.751n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365087
PNG
(4-(3-(4-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClN8O/c1-31-19(7-9-26-31)28-23-25-8-6-18(27-23)15-11-20-29-30-22-16(13-33-21(12-15)32(20)22)10-14-2-4-17(24)5-3-14/h2-9,11-12,16H,10,13H2,1H3,(H,25,27,28)
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n/an/a 0.783n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365189
PNG
(4-(3-(3-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...)
Show SMILES COc1cccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)c1
Show InChI InChI=1/C25H23N7O2/c1-31-22(7-9-27-31)28-21-12-17(6-8-26-21)18-13-23-29-30-25-19(15-34-24(14-18)32(23)25)10-16-4-3-5-20(11-16)33-2/h3-9,11-14,19H,10,15H2,1-2H3,(H,26,28)
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n/an/a 0.794n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365178
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-phenoxy-8,9- di...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Oc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20N8O2/c1-30-19(8-11-25-30)27-23-24-10-7-17(26-23)15-13-20-28-29-22-18(33-16-5-3-2-4-6-16)9-12-32-21(14-15)31(20)22/h2-8,10-11,13-14,18H,9,12H2,1H3,(H,24,26,27)/t18-/s2
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n/an/a 0.942n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365021
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@@H](c3nnc(c1)n23)c1ccccc1
Show InChI InChI=1/C22H19N9/c1-30-18(8-10-25-30)27-22-23-9-7-17(26-22)15-11-19-24-13-16(14-5-3-2-4-6-14)21-29-28-20(12-15)31(19)21/h2-12,16,24H,13H2,1H3,(H,23,26,27)/t16-/s2
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n/an/a 1.10n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365061
PNG
((R)-9-isobutyl-8-methyl-4-(2- ((1-methyl-1H-pyrazo...)
Show SMILES CC(C)C[C@H]1N(C)C(=O)Nc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H24N10O/c1-12(2)9-15-19-28-27-18-11-13(10-17(31(18)19)26-21(32)29(15)3)14-5-7-22-20(24-14)25-16-6-8-23-30(16)4/h5-8,10-12,15H,9H2,1-4H3,(H,26,32)(H,22,24,25)/t15-/s2
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n/an/a 1.12n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365054
PNG
((R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CC(C)C[C@H]1N(C)C(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C22H26N10O/c1-13(2)10-16-20-28-27-18-11-14(12-19(32(18)20)30(4)22(33)29(16)3)15-6-8-23-21(25-15)26-17-7-9-24-31(17)5/h6-9,11-13,16H,10H2,1-5H3,(H,23,25,26)/t16-/s2
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n/an/a 1.15n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365076
PNG
(4-(3-benzyl-3-methyl-3,4- dihydro-5-oxa-1,2,2a1- t...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(C)(Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C24H22N8O/c1-24(14-16-6-4-3-5-7-16)15-33-21-13-17(12-20-29-30-22(24)32(20)21)18-8-10-25-23(27-18)28-19-9-11-26-31(19)2/h3-13H,14-15H2,1-2H3,(H,25,27,28)
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n/an/a 1.17n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365090
PNG
(4-(3-((2-methoxypyridin-3- yl)methyl)-5-methyl-4,5...)
Show SMILES COc1ncccc1CC1CN(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H24N10O/c1-32-14-17(11-15-5-4-8-25-23(15)35-3)22-31-30-20-12-16(13-21(32)34(20)22)18-6-9-26-24(28-18)29-19-7-10-27-33(19)2/h4-10,12-13,17H,11,14H2,1-3H3,(H,26,28,29)
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n/an/a 1.33n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365074
PNG
(4-(3-(4-fluorobenzyl)-5- methyl-4,5-dihydro-3H- 1,...)
Show SMILES CN1C[C@@H](Cc2ccc(F)cc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H22FN9/c1-32-14-17(11-15-3-5-18(25)6-4-15)23-31-30-21-12-16(13-22(32)34(21)23)19-7-9-26-24(28-19)29-20-8-10-27-33(20)2/h3-10,12-13,17H,11,14H2,1-2H3,(H,26,28,29)/t17-/s2
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n/an/a 1.35n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365085
PNG
(9-(4-chlorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CN1c2cc(cc3nnc([C@H](Cc4ccc(Cl)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C26H23ClN8O/c1-33-24-14-18(17-7-9-28-21(12-17)30-22-8-10-29-34(22)2)13-23-31-32-26(35(23)24)19(15-25(33)36)11-16-3-5-20(27)6-4-16/h3-10,12-14,19H,11,15H2,1-2H3,(H,28,30)/t19-/s2
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n/an/a 1.35n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365116
PNG
(4-(9-((4-cyclopropyl-1H- pyrazol-1-yl)methyl)-8,9-...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(Cn3cc(cn3)C3CC3)c3nnc(c1)n23
Show InChI InChI=1/C24H24N10O/c1-32-20(5-8-26-32)29-24-25-7-4-19(28-24)17-10-21-30-31-23-16(6-9-35-22(11-17)34(21)23)13-33-14-18(12-27-33)15-2-3-15/h4-5,7-8,10-12,14-16H,2-3,6,9,13H2,1H3,(H,25,28,29)
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n/an/a 1.39n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365147
PNG
(4-(3-benzyl-4-methyl-3,4- dihydro-5-oxa-1,2,2a1- t...)
Show SMILES C[C@H]1Oc2cc(cc3nnc([C@@H]1Cc1ccccc1)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H22N8O/c1-15-18(12-16-6-4-3-5-7-16)23-30-29-21-13-17(14-22(33-15)32(21)23)19-8-10-25-24(27-19)28-20-9-11-26-31(20)2/h3-11,13-15,18H,12H2,1-2H3,(H,25,27,28)/t15-,18-/s2
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n/an/a 1.55n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365033
PNG
(4-(3-(4-chlorobenzyl)-4,5- dihydro-3H-1,2,2a1,5- t...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2NC[C@@H](Cc3ccc(Cl)cc3)c3ncc(c1)n23
Show InChI InChI=1/C25H22ClN7/c1-32-23(7-9-30-32)31-22-12-17(6-8-27-22)18-11-21-15-29-25-19(14-28-24(13-18)33(21)25)10-16-2-4-20(26)5-3-16/h2-9,11-13,15,19,28H,10,14H2,1H3,(H,27,31)/t19-/s2
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n/an/a 1.55n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365195
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(3,3,3- trifluo...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](CCC(F)(F)F)c3nnc(c1)n23
Show InChI InChI=1/C20H19F3N8O/c1-30-15(4-8-25-30)27-19-24-7-3-14(26-19)13-10-16-28-29-18-12(2-6-20(21,22)23)5-9-32-17(11-13)31(16)18/h3-4,7-8,10-12H,2,5-6,9H2,1H3,(H,24,26,27)/t12-/s2
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n/an/a 1.70n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365063
PNG
(4-(3-((6-methoxypyridin-3- yl)methyl)-4,5-dihydro-...)
Show SMILES COc1ccc(C[C@@H]2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cn1
Show InChI InChI=1/C23H22N10O/c1-32-18(6-8-27-32)29-23-24-7-5-17(28-23)15-10-19-25-13-16(22-31-30-20(11-15)33(19)22)9-14-3-4-21(34-2)26-12-14/h3-8,10-12,16,25H,9,13H2,1-2H3,(H,24,28,29)/t16-/s2
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n/an/a 1.85n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365204
PNG
(4-(9-isobutyl-8,9-dihydro- 7H-6-oxa-1,2,2a1- triaz...)
Show SMILES CC(C)C[C@@H]1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H24N8O/c1-13(2)10-14-6-9-30-19-12-15(11-18-26-27-20(14)29(18)19)16-4-7-22-21(24-16)25-17-5-8-23-28(17)3/h4-5,7-8,11-14H,6,9-10H2,1-3H3,(H,22,24,25)/t14-/s2
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n/an/a 1.85n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365122
PNG
(4-(9-(3-fluoro-4- methoxybenzyl)-8,9- dihydro-7H-6...)
Show SMILES COc1ccc(CC2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F
Show InChI InChI=1/C25H23FN8O2/c1-33-21(6-9-28-33)30-25-27-8-5-19(29-25)17-13-22-31-32-24-16(7-10-36-23(14-17)34(22)24)11-15-3-4-20(35-2)18(26)12-15/h3-6,8-9,12-14,16H,7,10-11H2,1-2H3,(H,27,29,30)
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n/an/a 1.86n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365047
PNG
(4-(3-benzyl-3,4-dihydro-5- oxa-1,2,2a1- triazaacen...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C23H20N8O/c1-30-19(8-10-25-30)27-23-24-9-7-18(26-23)16-12-20-28-29-22-17(11-15-5-3-2-4-6-15)14-32-21(13-16)31(20)22/h2-10,12-13,17H,11,14H2,1H3,(H,24,26,27)
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n/an/a 2.24n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365067
PNG
(4-(3-((6-methoxypyridin-2- yl)methyl)-4,5-dihydro-...)
Show SMILES COc1cccc(C[C@@H]2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)n1
Show InChI InChI=1/C23H22N10O/c1-32-18(7-9-26-32)29-23-24-8-6-17(28-23)14-11-19-25-13-15(22-31-30-20(12-14)33(19)22)10-16-4-3-5-21(27-16)34-2/h3-9,11-12,15,25H,10,13H2,1-2H3,(H,24,28,29)/t15-/s2
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n/an/a 2.30n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365199
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-propyl-8,9-dihy...)
Show SMILES CCC[C@@H]1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H22N8O/c1-3-4-13-7-10-29-18-12-14(11-17-25-26-19(13)28(17)18)15-5-8-21-20(23-15)24-16-6-9-22-27(16)2/h5-6,8-9,11-13H,3-4,7,10H2,1-2H3,(H,21,23,24)/t13-/s2
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n/an/a 2.30n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365176
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((4-(trifluorom...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCCC(Cn3cc(cn3)C(F)(F)F)c3nnc(c1)n23
Show InChI InChI=1/C23H20F3N9O/c1-33-19(3-6-28-33)30-18-8-14(2-5-27-18)16-9-20-31-32-22-15(4-7-36-21(10-16)35(20)22)12-34-13-17(11-29-34)23(24,25)26/h2-3,5-6,8-11,13,15H,4,7,12H2,1H3,(H,27,30)
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n/an/a 2.31n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365106
PNG
((R)-9-(cyclopropylmethyl)-6- methyl-4-(2-((1-methy...)
Show SMILES CN1c2cc(cc3nnc([C@@H](CC4CC4)NC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H22N10O/c1-29-18-11-13(14-5-7-22-20(24-14)26-16-6-8-23-30(16)2)10-17-27-28-19(31(17)18)15(25-21(29)32)9-12-3-4-12/h5-8,10-12,15H,3-4,9H2,1-2H3,(H,25,32)(H,22,24,26)/t15-/s2
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n/an/a 2.34n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365181
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((1-methyl-1H- ...)
Show SMILES Cn1nccc1C[C@@H]1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C22H22N10O/c1-30-16(3-8-24-30)11-14-6-10-33-20-13-15(12-19-28-29-21(14)32(19)20)17-4-7-23-22(26-17)27-18-5-9-25-31(18)2/h3-5,7-9,12-14H,6,10-11H2,1-2H3,(H,23,26,27)/t14-/s2
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n/an/a 2.42n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365097
PNG
(4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-ox...)
Show SMILES COc1ccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F
Show InChI InChI=1/C24H21FN8O2/c1-32-20(6-8-27-32)29-24-26-7-5-18(28-24)15-11-21-30-31-23-16(13-35-22(12-15)33(21)23)9-14-3-4-19(34-2)17(25)10-14/h3-8,10-12,16H,9,13H2,1-2H3,(H,26,28,29)
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n/an/a 2.47n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365071
PNG
(4-(9-(2-chlorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC[C@@H](Cc3ccccc3Cl)c3nnc(c1)n23
Show InChI InChI=1/C25H22ClN7O/c1-32-22(7-10-28-32)29-21-13-16(6-9-27-21)19-14-23-30-31-25-18(8-11-34-24(15-19)33(23)25)12-17-4-2-3-5-20(17)26/h2-7,9-10,13-15,18H,8,11-12H2,1H3,(H,27,29)/t18-/s2
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n/an/a 2.55n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365071
PNG
(4-(9-(2-chlorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC[C@@H](Cc3ccccc3Cl)c3nnc(c1)n23
Show InChI InChI=1/C25H22ClN7O/c1-32-22(7-10-28-32)29-21-13-16(6-9-27-21)19-14-23-30-31-25-18(8-11-34-24(15-19)33(23)25)12-17-4-2-3-5-20(17)26/h2-7,9-10,13-15,18H,8,11-12H2,1H3,(H,27,29)/t18-/s2
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n/an/a 2.55n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365213
PNG
(4-(9-(3,4-difluorophenoxy)- 8,9-dihydro-7H-6-oxa- ...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Oc3ccc(F)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H18F2N8O2/c1-32-19(5-8-27-32)29-23-26-7-4-17(28-23)13-10-20-30-31-22-18(6-9-34-21(11-13)33(20)22)35-14-2-3-15(24)16(25)12-14/h2-5,7-8,10-12,18H,6,9H2,1H3,(H,26,28,29)/t18-/s2
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n/an/a 2.60n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365037
PNG
(4-(3-isobutyl-4,5-dihydro- 3H-1,2,2a1,5- tetraazaa...)
Show SMILES CC(C)C[C@@H]1CNc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H23N9/c1-12(2)8-14-11-22-17-9-13(10-18-26-27-19(14)29(17)18)15-4-6-21-20(24-15)25-16-5-7-23-28(16)3/h4-7,9-10,12,14,22H,8,11H2,1-3H3,(H,21,24,25)/t14-/s2
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n/an/a 2.75n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365197
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-propyl-8,9-dihy...)
Show SMILES CCC[C@@H]1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C21H23N7O/c1-3-4-14-7-10-29-20-13-16(12-19-25-26-21(14)28(19)20)15-5-8-22-17(11-15)24-18-6-9-23-27(18)2/h5-6,8-9,11-14H,3-4,7,10H2,1-2H3,(H,22,24)/t14-/s2
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n/an/a 2.77n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365150
PNG
(9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-m...)
Show SMILES COc1ccc(CC2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)c(F)c1
Show InChI InChI=1/C27H25FN8O2/c1-34-25-13-18(16-6-8-29-22(11-16)31-23-7-9-30-35(23)2)12-24-32-33-27(36(24)25)19(14-26(34)37)10-17-4-5-20(38-3)15-21(17)28/h4-9,11-13,15,19H,10,14H2,1-3H3,(H,29,31)
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n/an/a 2.85n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365136
PNG
(4-(9-(4-fluorophenoxy)- 8,9-dihydro-7H-6-oxa- 1,2,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Oc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19FN8O2/c1-31-19(7-10-26-31)28-23-25-9-6-17(27-23)14-12-20-29-30-22-18(8-11-33-21(13-14)32(20)22)34-16-4-2-15(24)3-5-16/h2-7,9-10,12-13,18H,8,11H2,1H3,(H,25,27,28)/t18-/s2
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n/an/a 2.95n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365136
PNG
(4-(9-(4-fluorophenoxy)- 8,9-dihydro-7H-6-oxa- 1,2,...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Oc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19FN8O2/c1-31-19(7-10-26-31)28-23-25-9-6-17(27-23)14-12-20-29-30-22-18(8-11-33-21(13-14)32(20)22)34-16-4-2-15(24)3-5-16/h2-7,9-10,12-13,18H,8,11H2,1H3,(H,25,27,28)/t18-/s2
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n/an/a 2.95n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365151
PNG
(9-isobutyl-6-methyl-4-(2-((1- methyl-1H-pyrazol-5-...)
Show SMILES CC(C)C[C@@H]1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C23H26N8O/c1-14(2)9-17-13-22(32)29(3)21-12-16(11-20-27-28-23(17)31(20)21)15-5-7-24-18(10-15)26-19-6-8-25-30(19)4/h5-8,10-12,14,17H,9,13H2,1-4H3,(H,24,26)/t17-/s2
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n/an/a 3.22n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365051
PNG
(4-(3-benzyl-5-ethyl-4,5- dihydro-3H-1,2,2a1,5- tet...)
Show SMILES CCN1C[C@@H](Cc2ccccc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H25N9/c1-3-33-16-19(13-17-7-5-4-6-8-17)24-31-30-22-14-18(15-23(33)34(22)24)20-9-11-26-25(28-20)29-21-10-12-27-32(21)2/h4-12,14-15,19H,3,13,16H2,1-2H3,(H,26,28,29)/t19-/s2
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n/an/a 3.39n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365064
PNG
((R)-9-isobutyl-6-methyl-4- (2-((1-methyl-1H-pyrazo...)
Show SMILES CC(C)C[C@H]1NC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C22H25N9O/c1-13(2)9-16-21-28-27-19-11-15(12-20(31(19)21)29(3)22(32)25-16)14-5-7-23-17(10-14)26-18-6-8-24-30(18)4/h5-8,10-13,16H,9H2,1-4H3,(H,23,26)(H,25,32)/t16-/s2
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n/an/a 4.28n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365082
PNG
(4-(3-benzyl-3,4-dihydro-5- oxa-1,2,2a1- triazaacen...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C24H21N7O/c1-30-21(8-10-26-30)27-20-12-17(7-9-25-20)18-13-22-28-29-24-19(11-16-5-3-2-4-6-16)15-32-23(14-18)31(22)24/h2-10,12-14,19H,11,15H2,1H3,(H,25,27)
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n/an/a 4.34n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365157
PNG
(4-(9-((5-chloropyridin-3- yl)oxy)-8,9-dihydro-7H-6...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC[C@@H](Oc3cncc(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClN8O2/c1-31-20(3-6-27-31)28-19-8-14(2-5-26-19)15-9-21-29-30-23-18(4-7-33-22(10-15)32(21)23)34-17-11-16(24)12-25-13-17/h2-3,5-6,8-13,18H,4,7H2,1H3,(H,26,28)/t18-/s2
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n/an/a 4.61n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365093
PNG
(4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1 -...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C23H19FN8O/c1-31-19(7-9-26-31)28-23-25-8-6-18(27-23)15-11-20-29-30-22-16(13-33-21(12-15)32(20)22)10-14-2-4-17(24)5-3-14/h2-9,11-12,16H,10,13H2,1H3,(H,25,27,28)
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n/an/a 5n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365035
PNG
(4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- te...)
Show SMILES CN1C[C@@H](Cc2ccccc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H23N9/c1-31-15-18(12-16-6-4-3-5-7-16)23-30-29-21-13-17(14-22(31)33(21)23)19-8-10-25-24(27-19)28-20-9-11-26-32(20)2/h3-11,13-14,18H,12,15H2,1-2H3,(H,25,27,28)/t18-/s2
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n/an/a 5.04n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365080
PNG
(4-(3-benzyl-3-methyl-3,4- dihydro-5-oxa-1,2,2a1- t...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(C)(Cc3ccccc3)c3nnc(c1)n23
Show InChI InChI=1/C25H23N7O/c1-25(15-17-6-4-3-5-7-17)16-33-23-14-19(13-22-29-30-24(25)32(22)23)18-8-10-26-20(12-18)28-21-9-11-27-31(21)2/h3-14H,15-16H2,1-2H3,(H,26,28)
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n/an/a 5.32n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365126
PNG
(9-benzyl-6-methyl-4-(2- ((1-methyl-1H-pyrazol-5- y...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccccc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C26H24N8O/c1-32-24-15-19(18-8-10-27-21(13-18)29-22-9-11-28-33(22)2)14-23-30-31-26(34(23)24)20(16-25(32)35)12-17-6-4-3-5-7-17/h3-11,13-15,20H,12,16H2,1-2H3,(H,27,29)
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n/an/a 5.83n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365103
PNG
(4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-ox...)
Show SMILES COc1ccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1F
Show InChI InChI=1/C25H22FN7O2/c1-32-22(6-8-28-32)29-21-11-16(5-7-27-21)17-12-23-30-31-25-18(14-35-24(13-17)33(23)25)9-15-3-4-20(34-2)19(26)10-15/h3-8,10-13,18H,9,14H2,1-2H3,(H,27,29)
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n/an/a 6.22n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365173
PNG
(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3cccc(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H19ClN8O/c1-31-19(6-8-26-31)28-23-25-7-5-18(27-23)15-11-20-29-30-22-16(13-33-21(12-15)32(20)22)9-14-3-2-4-17(24)10-14/h2-8,10-12,16H,9,13H2,1H3,(H,25,27,28)
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n/an/a 6.36n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365137
PNG
(9-benzyl-6-methyl-4-(2-((1- methyl-1H-pyrazol-5- y...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccccc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H23N9O/c1-32-22-14-17(19-8-10-26-25(28-19)29-20-9-11-27-33(20)2)13-21-30-31-24(34(21)22)18(15-23(32)35)12-16-6-4-3-5-7-16/h3-11,13-14,18H,12,15H2,1-2H3,(H,26,28,29)
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n/an/a 6.49n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365171
PNG
(9-isopropyl-6-methyl-4-(2- ((1-methyl-1H-pyrazol-5...)
Show SMILES CC(C)[C@@H]1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C22H24N8O/c1-13(2)16-12-21(31)28(3)20-11-15(10-19-26-27-22(16)30(19)20)14-5-7-23-17(9-14)25-18-6-8-24-29(18)4/h5-11,13,16H,12H2,1-4H3,(H,23,25)/t16-/s2
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n/an/a 6.94n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365105
PNG
(4-(3-(4-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...)
Show SMILES COc1ccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1/C24H22N8O2/c1-31-20(8-10-26-31)28-24-25-9-7-19(27-24)16-12-21-29-30-23-17(14-34-22(13-16)32(21)23)11-15-3-5-18(33-2)6-4-15/h3-10,12-13,17H,11,14H2,1-2H3,(H,25,27,28)
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n/an/a 7.12n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365130
PNG
(9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-...)
Show SMILES COc1ccc(CC2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1
Show InChI InChI=1/C27H26N8O2/c1-33-25-15-19(18-8-10-28-22(13-18)30-23-9-11-29-34(23)2)14-24-31-32-27(35(24)25)20(16-26(33)36)12-17-4-6-21(37-3)7-5-17/h4-11,13-15,20H,12,16H2,1-3H3,(H,28,30)
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n/an/a 7.17n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365043
PNG
(4-(3-(4-chlorobenzyl)-5- methyl-4,5-dihydro-3H- 1,...)
Show SMILES CN1C[C@@H](Cc2ccc(Cl)cc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C25H23ClN8/c1-32-15-19(11-16-3-5-20(26)6-4-16)25-31-30-23-13-18(14-24(32)34(23)25)17-7-9-27-21(12-17)29-22-8-10-28-33(22)2/h3-10,12-14,19H,11,15H2,1-2H3,(H,27,29)/t19-/s2
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n/an/a 8.60n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365169
PNG
(6-methyl-4-(2-((1-methyl-1H- pyrazol-5-yl)amino)py...)
Show SMILES CN1c2cc(cc3nnc([C@H](CC(F)(F)F)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C21H19F3N8O/c1-30-18-9-13(12-3-5-25-15(7-12)27-16-4-6-26-31(16)2)8-17-28-29-20(32(17)18)14(10-19(30)33)11-21(22,23)24/h3-9,14H,10-11H2,1-2H3,(H,25,27)/t14-/s2
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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365110
PNG
(4-(3-(3,4-difluorobenzyl)-3,4- dihydro-5-oxa-1,2,2...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3ccc(F)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H18F2N8O/c1-32-19(5-7-27-32)29-23-26-6-4-18(28-23)14-10-20-30-31-22-15(12-34-21(11-14)33(20)22)8-13-2-3-16(24)17(25)9-13/h2-7,9-11,15H,8,12H2,1H3,(H,26,28,29)
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n/an/a 11.3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365118
PNG
(4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccc(F)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H20FN7O/c1-31-21(7-9-27-31)28-20-11-16(6-8-26-20)17-12-22-29-30-24-18(14-33-23(13-17)32(22)24)10-15-2-4-19(25)5-3-15/h2-9,11-13,18H,10,14H2,1H3,(H,26,28)
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n/an/a 11.4n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365101
PNG
(4-(3-(4-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H20ClN7O/c1-31-21(7-9-27-31)28-20-11-16(6-8-26-20)17-12-22-29-30-24-18(14-33-23(13-17)32(22)24)10-15-2-4-19(25)5-3-15/h2-9,11-13,18H,10,14H2,1H3,(H,26,28)
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n/an/a 12.3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365163
PNG
(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5- oxa...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3ccc(F)c(Cl)c3)c3nnc(c1)n23
Show InChI InChI=1/C23H18ClFN8O/c1-32-19(5-7-27-32)29-23-26-6-4-18(28-23)14-10-20-30-31-22-15(12-34-21(11-14)33(20)22)8-13-2-3-17(25)16(24)9-13/h2-7,9-11,15H,8,12H2,1H3,(H,26,28,29)
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n/an/a 12.4n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365101
PNG
(4-(3-(4-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccc(Cl)cc3)c3nnc(c1)n23
Show InChI InChI=1/C24H20ClN7O/c1-31-21(7-9-27-31)28-20-11-16(6-8-26-20)17-12-22-29-30-24-18(14-33-23(13-17)32(22)24)10-15-2-4-19(25)5-3-15/h2-9,11-13,18H,10,14H2,1H3,(H,26,28)
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n/an/a 12.5n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365159
PNG
(9-(4-fluorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccc(F)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H22FN9O/c1-33-22-13-16(19-7-9-27-25(29-19)30-20-8-10-28-34(20)2)12-21-31-32-24(35(21)22)17(14-23(33)36)11-15-3-5-18(26)6-4-15/h3-10,12-13,17H,11,14H2,1-2H3,(H,27,29,30)
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n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365143
PNG
(9-(4-fluorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccc(F)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C26H23FN8O/c1-33-24-14-18(17-7-9-28-21(12-17)30-22-8-10-29-34(22)2)13-23-31-32-26(35(23)24)19(15-25(33)36)11-16-3-5-20(27)6-4-16/h3-10,12-14,19H,11,15H2,1-2H3,(H,28,30)
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n/an/a 17.2n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365183
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((3-methylisoxa...)
Show SMILES Cc1cc(CC2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)on1
Show InChI InChI=1/C22H21N9O2/c1-13-9-16(33-29-13)10-14-5-8-32-20-12-15(11-19-27-28-21(14)31(19)20)17-3-6-23-22(25-17)26-18-4-7-24-30(18)2/h3-4,6-7,9,11-12,14H,5,8,10H2,1-2H3,(H,23,25,26)
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n/an/a 18.2n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365193
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-propyl-3,4-dihy...)
Show SMILES CCCC1COc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C19H20N8O/c1-3-4-12-11-28-17-10-13(9-16-24-25-18(12)27(16)17)14-5-7-20-19(22-14)23-15-6-8-21-26(15)2/h5-10,12H,3-4,11H2,1-2H3,(H,20,22,23)
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n/an/a 19.5n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365095
PNG
(4-(3-isobutyl-3,4-dihydro-5- oxa-1,2,2a1- triazaac...)
Show SMILES CC(C)CC1COc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H22N8O/c1-12(2)8-14-11-29-18-10-13(9-17-25-26-19(14)28(17)18)15-4-6-21-20(23-15)24-16-5-7-22-27(16)3/h4-7,9-10,12,14H,8,11H2,1-3H3,(H,21,23,24)
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n/an/a 20.9n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365112
PNG
(4-(3-(3,4-difluorobenzyl)-3,4- dihydro-5-oxa-1,2,2...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccc(F)c(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C24H19F2N7O/c1-32-21(5-7-28-32)29-20-10-15(4-6-27-20)16-11-22-30-31-24-17(13-34-23(12-16)33(22)24)8-14-2-3-18(25)19(26)9-14/h2-7,9-12,17H,8,13H2,1H3,(H,27,29)
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n/an/a 22.3n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365180
PNG
(4-(9-((5-fluoropyridin-3- yl)oxy)-8,9-dihydro-7H-6...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@@H](Oc3cncc(F)c3)c3nnc(c1)n23
Show InChI InChI=1/C22H18FN9O2/c1-31-18(3-6-26-31)28-22-25-5-2-16(27-22)13-8-19-29-30-21-17(4-7-33-20(9-13)32(19)21)34-15-10-14(23)11-24-12-15/h2-3,5-6,8-12,17H,4,7H2,1H3,(H,25,27,28)/t17-/s2
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n/an/a 25.8n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365168
PNG
(9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-m...)
Show SMILES COc1ccc(CC2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)c(F)c1
Show InChI InChI=1/C26H24FN9O2/c1-34-23-12-16(20-6-8-28-26(30-20)31-21-7-9-29-35(21)2)11-22-32-33-25(36(22)23)17(13-24(34)37)10-15-4-5-18(38-3)14-19(15)27/h4-9,11-12,14,17H,10,13H2,1-3H3,(H,28,30,31)
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n/an/a 25.9n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365166
PNG
(9-((5-chloropyridin-2- yl)methyl)-6-methyl-4-(2-((...)
Show SMILES CN1c2cc(cc3nnc(C(Cc4ccc(Cl)cn4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H21ClN10O/c1-33-21-11-14(18-5-7-26-24(29-18)30-19-6-8-28-34(19)2)10-20-31-32-23(35(20)21)15(12-22(33)36)9-17-4-3-16(25)13-27-17/h3-8,10-11,13,15H,9,12H2,1-2H3,(H,26,29,30)
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n/an/a 32.7n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365026
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2NC[C@H](c3nnc(c1)n23)c1ccccc1
Show InChI InChI=1/C23H20N8/c1-30-20(8-10-26-30)27-19-11-16(7-9-24-19)17-12-21-25-14-18(15-5-3-2-4-6-15)23-29-28-22(13-17)31(21)23/h2-13,18,25H,14H2,1H3,(H,24,27)/t18-/s2
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n/an/a 43.1n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365128
PNG
(9-(4-methoxybenzyl)-6- methyl-4-(2-((1-methyl- 1H-...)
Show SMILES COc1ccc(CC2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1/C26H25N9O2/c1-33-23-14-17(20-8-10-27-26(29-20)30-21-9-11-28-34(21)2)13-22-31-32-25(35(22)23)18(15-24(33)36)12-16-4-6-19(37-3)7-5-16/h4-11,13-14,18H,12,15H2,1-3H3,(H,27,29,30)
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n/an/a 44n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365055
PNG
(4-(3-isobutyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- ...)
Show SMILES CC(C)C[C@@H]1CN(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C22H26N8/c1-14(2)9-17-13-28(3)21-12-16(11-20-26-27-22(17)30(20)21)15-5-7-23-18(10-15)25-19-6-8-24-29(19)4/h5-8,10-12,14,17H,9,13H2,1-4H3,(H,23,25)/t17-/s2
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n/an/a 48.7n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365139
PNG
(9-isobutyl-6-methyl-4-(2-((1- methyl-1H-pyrazol-5-...)
Show SMILES CC(C)CC1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C22H25N9O/c1-13(2)9-15-12-20(32)29(3)19-11-14(10-18-27-28-21(15)31(18)19)16-5-7-23-22(25-16)26-17-6-8-24-30(17)4/h5-8,10-11,13,15H,9,12H2,1-4H3,(H,23,25,26)
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n/an/a 52n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365052
PNG
(4-(3-(4-methoxybenzyl)-5- methyl-4,5-dihydro-3H- 1...)
Show SMILES COc1ccc(CC2CN(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)cc1
Show InChI InChI=1/C26H26N8O/c1-32-16-20(12-17-4-6-21(35-3)7-5-17)26-31-30-24-14-19(15-25(32)34(24)26)18-8-10-27-22(13-18)29-23-9-11-28-33(23)2/h4-11,13-15,20H,12,16H2,1-3H3,(H,27,29)
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n/an/a 55.8n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365060
PNG
(9-(4-chlorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Show SMILES CN1c2cc(cc3nnc([C@H](Cc4ccc(Cl)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C25H22ClN9O/c1-33-22-13-16(19-7-9-27-25(29-19)30-20-8-10-28-34(20)2)12-21-31-32-24(35(21)22)17(14-23(33)36)11-15-3-5-18(26)6-4-15/h3-10,12-13,17H,11,14H2,1-2H3,(H,27,29,30)/t17-/s2
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n/an/a 88.2n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365107
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-(2-methylbutyl)...)
Show SMILES CCC(C)CC1COc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H24N8O/c1-4-13(2)9-15-12-30-19-11-14(10-18-26-27-20(15)29(18)19)16-5-7-22-21(24-16)25-17-6-8-23-28(17)3/h5-8,10-11,13,15H,4,9,12H2,1-3H3,(H,22,24,25)
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n/an/a 93.4n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365134
PNG
(9-cyclopropyl-6-methyl- 4-(2-((1-methyl-1H- pyrazo...)
Show SMILES CN1c2cc(cc3nnc(C(CC1=O)C1CC1)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H21N9O/c1-28-18-10-13(15-5-7-22-21(24-15)25-16-6-8-23-29(16)2)9-17-26-27-20(30(17)18)14(11-19(28)31)12-3-4-12/h5-10,12,14H,3-4,11H2,1-2H3,(H,22,24,25)
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n/an/a 119n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365091
PNG
(4-(3-((2-methoxypyridin-3- yl)methyl)-5-methyl-4,5...)
Show SMILES COc1ncccc1C[C@@H]1CN(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C24H24N10O/c1-32-14-17(11-15-5-4-8-25-23(15)35-3)22-31-30-20-12-16(13-21(32)34(20)22)18-6-9-26-24(28-18)29-19-7-10-27-33(19)2/h4-10,12-13,17H,11,14H2,1-3H3,(H,26,28,29)/t17-/s2
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n/an/a 120n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365020
PNG
(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-phenyl-4,5-dihy...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1cc2NC[C@H](c3nnc(c1)n23)c1ccccc1
Show InChI InChI=1/C22H19N9/c1-30-18(8-10-25-30)27-22-23-9-7-17(26-22)15-11-19-24-13-16(14-5-3-2-4-6-14)21-29-28-20(12-15)31(19)21/h2-12,16,24H,13H2,1H3,(H,23,26,27)/t16-/s2
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n/an/a 179n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365132
PNG
(6-methyl-4-(2-((1-methyl- 1H-pyrazol-5- yl)amino)p...)
Show SMILES CCC[C@@H]1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H23N9O/c1-4-5-13-12-19(31)28(2)18-11-14(10-17-26-27-20(13)30(17)18)15-6-8-22-21(24-15)25-16-7-9-23-29(16)3/h6-11,13H,4-5,12H2,1-3H3,(H,22,24,25)/t13-/s2
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n/an/a 183n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365145
PNG
(6-methyl-4-(2-((1-methyl-1H- pyrazol-5- yl)amino)p...)
Show SMILES CN1c2cc(cc3nnc(C(CC(F)(F)F)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C20H18F3N9O/c1-30-16-8-11(13-3-5-24-19(26-13)27-14-4-6-25-31(14)2)7-15-28-29-18(32(15)16)12(9-17(30)33)10-20(21,22)23/h3-8,12H,9-10H2,1-2H3,(H,24,26,27)
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n/an/a 189n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365170
PNG
(6-methyl-4-(2-((1-methyl-1H- pyrazol-5-yl)amino)py...)
Show SMILES CN1c2cc(cc3nnc(C(CC(F)(F)F)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C21H19F3N8O/c1-30-18-9-13(12-3-5-25-15(7-12)27-16-4-6-26-31(16)2)8-17-28-29-20(32(17)18)14(10-19(30)33)11-21(22,23)24/h3-9,14H,10-11H2,1-2H3,(H,25,27)
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n/an/a 212n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365141
PNG
(9-isopropyl-6-methyl-4-(2- ((1-methyl-1H-pyrazol-5...)
Show SMILES CC(C)C1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1/C21H23N9O/c1-12(2)14-11-19(31)28(3)18-10-13(9-17-26-27-20(14)30(17)18)15-5-7-22-21(24-15)25-16-6-8-23-29(16)4/h5-10,12,14H,11H2,1-4H3,(H,22,24,25)
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n/an/a 369n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365185
PNG
((R)-9-((5-chloropyridin-2- yl)methyl)-6-methyl-4-(...)
Show SMILES CN1c2cc(cc3nnc([C@H](Cc4ccc(Cl)cn4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C25H22ClN9O/c1-33-23-12-16(15-5-7-27-20(10-15)30-21-6-8-29-34(21)2)11-22-31-32-25(35(22)23)17(13-24(33)36)9-19-4-3-18(26)14-28-19/h3-8,10-12,14,17H,9,13H2,1-2H3,(H,27,30)/t17-/s2
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n/an/a 598n/an/an/an/an/an/a



GENENTECH, INC.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9867833 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM365152
PNG
(9-isobutyl-6-methyl-4-(2-((1- methyl-1H-pyrazol-5-...)
Show SMILES CC(C)CC1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1
Show InChI InChI=1/C23H26N8O/c1-14(2)9-17-13-22(32)29(3)21-12-16(11-20-27-28-23(17)31(20)21)15-5-7-24-18(10-15)26-19-6-8-25-30(19)4/h5-8,10-12,14,17H,9,13H2,1-4H3,(H,24,26)
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