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Patent code US9868726

Compile Data Set for Download or QSAR
Found 123 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365349
PNG
(US9868726, Example 54 | methyl 5-[N-({6-amino-5-[5...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(C)ccc3F)ccc2s1
Show InChI InChI=1/C29H30FN5O5S2/c1-17-7-9-22(30)23(12-17)34-29(38)33-20-8-10-24-18(13-20)15-25(41-24)21-14-19(16-32-27(21)31)28(37)35-42(3,39)11-5-4-6-26(36)40-2/h7-10,12-16H,4-6,11H2,1-3H3,(H2,31,32)(H2,33,34,38)/t42-/s2
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n/an/a 3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM363234
PNG
(6-amino-5-[5-({[(3-chloro-4- fluorophenyl)amino]ca...)
Show SMILES C[C@H]([C@H](O)c1ccc(F)cn1)S(N)(=O)=O
Show InChI InChI=1S/C23H19ClFN5O3S2/c1-35(2,33)30-22(31)13-8-16(21(26)27-11-13)20-9-12-7-14(4-6-19(12)34-20)28-23(32)29-15-3-5-18(25)17(24)10-15/h3-11H,1-2H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365350
PNG
(US9868726, Example 55 | methyl 5-[N-({6-amino-5-[5...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1/C28H27ClFN5O5S2/c1-40-25(36)5-3-4-10-42(2,39)35-27(37)17-12-20(26(31)32-15-17)24-13-16-11-18(7-9-23(16)41-24)33-28(38)34-19-6-8-22(30)21(29)14-19/h6-9,11-15H,3-5,10H2,1-2H3,(H2,31,32)(H2,33,34,38)/t42-/s2
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365348
PNG
(US9868726, Example 53 | methyl 5-[N-({6-amino-5-[5...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1/C29H31N5O5S2/c1-18-7-6-8-21(13-18)32-29(37)33-22-10-11-24-19(14-22)16-25(40-24)23-15-20(17-31-27(23)30)28(36)34-41(3,38)12-5-4-9-26(35)39-2/h6-8,10-11,13-17H,4-5,9,12H2,1-3H3,(H2,30,31)(H2,32,33,37)/t41-/s2
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365355
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(C)(C)=O)c1
Show InChI InChI=1S/C22H22FN5O3S/c1-13-4-9-18(23)19(10-13)27-22(30)26-16-7-5-14(6-8-16)17-11-15(12-25-20(17)24)21(29)28-32(2,3)31/h4-12H,1-3H3,(H2,24,25)(H2,26,27,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365369
PNG
(US9868726, Example 74 | methyl 6-amino-5-[4-({[2- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F4N4O3/c1-32-19(30)12-8-15(18(26)27-10-12)11-2-5-14(6-3-11)28-20(31)29-17-9-13(21(23,24)25)4-7-16(17)22/h2-10H,1H3,(H2,26,27)(H2,28,29,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365370
PNG
(US9868726, Example 75 | methyl 6-amino-5-[4-({[4- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-32-19(30)12-8-15(18(26)27-10-12)11-2-4-13(5-3-11)28-20(31)29-14-6-7-17(22)16(9-14)21(23,24)25/h2-10H,1H3,(H2,26,27)(H2,28,29,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364986
PNG
(US9868726, Example 7 | methyl 6-amino-5-{5-[({[3- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H17F3N4O3S/c1-33-21(31)13-8-17(20(27)28-11-13)19-9-12-7-16(5-6-18(12)34-19)30-22(32)29-15-4-2-3-14(10-15)23(24,25)26/h2-11H,1H3,(H2,27,28)(H2,29,30,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365352
PNG
(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM363197
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES COc1cnc(cn1)[C@H](O)[C@H](C)S(N)(=O)=O
Show InChI InChI=1S/C24H23N5O3S2/c1-14-5-4-6-17(9-14)27-24(31)28-18-7-8-20-15(10-18)12-21(33-20)19-11-16(13-26-22(19)25)23(30)29-34(2,3)32/h4-13H,1-3H3,(H2,25,26)(H2,27,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365351
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda4- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)NS(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C28H31N5O5S2/c1-18-5-2-6-21(13-18)31-28(37)32-22-7-8-24-19(14-22)16-25(39-24)23-15-20(17-30-26(23)29)27(36)33-40(38,11-3-9-34)12-4-10-35/h2,5-8,13-17,34-35H,3-4,9-12H2,1H3,(H2,29,30)(H2,31,32,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM363243
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CO[C@@H]([C@@H](C)S(N)(=O)=O)c1ccc(Br)cc1F
Show InChI InChI=1S/C24H22FN5O3S2/c1-13-4-6-18(25)19(8-13)29-24(32)28-16-5-7-20-14(9-16)11-21(34-20)17-10-15(12-27-22(17)26)23(31)30-35(2,3)33/h4-12H,1-3H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365351
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda4- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(=O)NS(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C28H31N5O5S2/c1-18-5-2-6-21(13-18)31-28(37)32-22-7-8-24-19(14-22)16-25(39-24)23-15-20(17-30-26(23)29)27(36)33-40(38,11-3-9-34)12-4-10-35/h2,5-8,13-17,34-35H,3-4,9-12H2,1H3,(H2,29,30)(H2,31,32,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364999
PNG
(US9868726, Example 16 | methyl 6-amino-5-[5-({[(2,...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)cc3F)ccc2s1
Show InChI InChI=1S/C22H16F2N4O3S/c1-31-21(29)12-7-15(20(25)26-10-12)19-8-11-6-14(3-5-18(11)32-19)27-22(30)28-17-4-2-13(23)9-16(17)24/h2-10H,1H3,(H2,25,26)(H2,27,28,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365368
PNG
(US9868726, Example 73 | methyl 6-amino-5-(4-{[(2- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C21H19FN4O3/c1-12-3-8-17(22)18(9-12)26-21(28)25-15-6-4-13(5-7-15)16-10-14(20(27)29-2)11-24-19(16)23/h3-11H,1-2H3,(H2,23,24)(H2,25,26,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364997
PNG
(US9868726, Example 14 | methyl 6-amino-5-[5-({[(2-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3F)ccc2s1
Show InChI InChI=1S/C22H17FN4O3S/c1-30-21(28)13-9-15(20(24)25-11-13)19-10-12-8-14(6-7-18(12)31-19)26-22(29)27-17-5-3-2-4-16(17)23/h2-11H,1H3,(H2,24,25)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365217
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H28BFN4O3S/c1-15-6-8-20(29)21(10-15)33-25(34)32-18-7-9-22-16(11-18)12-23(37-22)19-13-17(14-31-24(19)30)28-35-26(2,3)27(4,5)36-28/h6-14H,1-5H3,(H2,30,31)(H2,32,33,34)
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n/an/a 10n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364990
PNG
(US9868726, Example 8 | methyl 6-amino-5-{5-[({[2- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16F4N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-14(3-5-18(11)35-19)30-22(33)31-17-9-13(23(25,26)27)2-4-16(17)24/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365013
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BF4N4O3S/c1-25(2)26(3,4)39-28(38-25)16-12-18(23(33)34-13-16)22-10-14-9-17(6-8-21(14)40-22)35-24(37)36-20-11-15(27(30,31)32)5-7-19(20)29/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364986
PNG
(US9868726, Example 7 | methyl 6-amino-5-{5-[({[3- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H17F3N4O3S/c1-33-21(31)13-8-17(20(27)28-11-13)19-9-12-7-16(5-6-18(12)34-19)30-22(32)29-15-4-2-3-14(10-15)23(24,25)26/h2-11H,1H3,(H2,27,28)(H2,29,30,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364996
PNG
(US9868726, Example 13 | methyl 6-amino-5-[5-({[(4-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(C)cc3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-3-5-16(6-4-13)26-23(29)27-17-7-8-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365367
PNG
(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C32H36F3N5O7S/c1-46-27(41)10-3-5-16-48(45,17-6-4-11-28(42)47-2)40-30(43)22-18-26(29(36)37-20-22)21-12-14-24(15-13-21)38-31(44)39-25-9-7-8-23(19-25)32(33,34)35/h7-9,12-15,18-20H,3-6,10-11,16-17H2,1-2H3,(H2,36,37)(H2,38,39,44)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365015
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H26BF3N4O3S/c1-25(2)26(3,4)38-28(37-25)17-13-20(23(32)33-14-17)22-11-15-10-19(8-9-21(15)39-22)35-24(36)34-18-7-5-6-16(12-18)27(29,30)31/h5-14H,1-4H3,(H2,32,33)(H2,34,35,36)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365364
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda6- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H31N5O5S/c1-18-5-2-6-22(15-18)30-26(35)29-21-9-7-19(8-10-21)23-16-20(17-28-24(23)27)25(34)31-37(36,13-3-11-32)14-4-12-33/h2,5-10,15-17,32-33H,3-4,11-14H2,1H3,(H2,27,28)(H2,29,30,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365353
PNG
(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-16(4-6-20(13)36-21)30-23(34)31-17-3-5-19(25)18(10-17)24(26,27)28/h3-12H,1-2H3,(H2,30,31,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365365
PNG
(US9868726, Example 70 | dimethyl 5,5'-(N-{[6-amino...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C32H39N5O7S/c1-22-9-8-10-26(19-22)36-32(41)35-25-15-13-23(14-16-25)27-20-24(21-34-30(27)33)31(40)37-45(42,17-6-4-11-28(38)43-2)18-7-5-12-29(39)44-3/h8-10,13-16,19-21H,4-7,11-12,17-18H2,1-3H3,(H2,33,34)(H2,35,36,41)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364992
PNG
(US9868726, Example 10 | methyl 6-amino-5-[5-({[(2-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H19FN4O3S/c1-12-3-5-17(24)18(7-12)28-23(30)27-15-4-6-19-13(8-15)10-20(32-19)16-9-14(22(29)31-2)11-26-21(16)25/h3-11H,1-2H3,(H2,25,26)(H2,27,28,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364991
PNG
(US9868726, Example 9 | methyl 6-amino-5-{5-[({[4- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16ClF3N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-13(3-5-18(11)35-19)30-22(33)31-14-2-4-17(24)16(9-14)23(25,26)27/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365216
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365348
PNG
(US9868726, Example 53 | methyl 5-[N-({6-amino-5-[5...)
Show SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1/C29H31N5O5S2/c1-18-7-6-8-21(13-18)32-29(37)33-22-10-11-24-19(14-22)16-25(40-24)23-15-20(17-31-27(23)30)28(36)34-41(3,38)12-5-4-9-26(35)39-2/h6-8,10-11,13-17H,4-5,9,12H2,1-3H3,(H2,30,31)(H2,32,33,37)/t41-/s2
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363243
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CO[C@@H]([C@@H](C)S(N)(=O)=O)c1ccc(Br)cc1F
Show InChI InChI=1S/C24H22FN5O3S2/c1-13-4-6-18(25)19(8-13)29-24(32)28-16-5-7-20-14(9-16)11-21(34-20)17-10-15(12-27-22(17)26)23(31)30-35(2,3)33/h4-12H,1-3H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365314
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccoc1C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C22H20N4O4S2/c1-12-6-7-30-19(12)22(28)25-15-4-5-17-13(8-15)10-18(31-17)16-9-14(11-24-20(16)23)21(27)26-32(2,3)29/h4-11H,1-3H3,(H2,23,24)(H,25,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364992
PNG
(US9868726, Example 10 | methyl 6-amino-5-[5-({[(2-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H19FN4O3S/c1-12-3-5-17(24)18(7-12)28-23(30)27-15-4-6-19-13(8-15)10-20(32-19)16-9-14(22(29)31-2)11-26-21(16)25/h3-11H,1-2H3,(H2,25,26)(H2,27,28,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363234
PNG
(6-amino-5-[5-({[(3-chloro-4- fluorophenyl)amino]ca...)
Show SMILES C[C@H]([C@H](O)c1ccc(F)cn1)S(N)(=O)=O
Show InChI InChI=1S/C23H19ClFN5O3S2/c1-35(2,33)30-22(31)13-8-16(21(26)27-11-13)20-9-12-7-14(4-6-19(12)34-20)28-23(32)29-15-3-5-18(25)17(24)10-15/h3-11H,1-2H3,(H2,26,27)(H2,28,29,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365013
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BF4N4O3S/c1-25(2)26(3,4)39-28(38-25)16-12-18(23(33)34-13-16)22-10-14-9-17(6-8-21(14)40-22)35-24(37)36-20-11-15(27(30,31)32)5-7-19(20)29/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364994
PNG
(US9868726, Example 11 | methyl 6-amino-5-[5-({[(3-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-4-3-5-16(8-13)26-23(29)27-17-6-7-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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n/an/a 18n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365308
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C28H31BN4O3S/c1-6-17-8-7-9-20(12-17)32-26(34)33-21-10-11-23-18(13-21)14-24(37-23)22-15-19(16-31-25(22)30)29-35-27(2,3)28(4,5)36-29/h7-16H,6H2,1-5H3,(H2,30,31)(H2,32,33,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM363197
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES COc1cnc(cn1)[C@H](O)[C@H](C)S(N)(=O)=O
Show InChI InChI=1S/C24H23N5O3S2/c1-14-5-4-6-17(9-14)27-24(31)28-18-7-8-20-15(10-18)12-21(33-20)19-11-16(13-26-22(19)25)23(30)29-34(2,3)32/h4-13H,1-3H3,(H2,25,26)(H2,27,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364994
PNG
(US9868726, Example 11 | methyl 6-amino-5-[5-({[(3-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-4-3-5-16(8-13)26-23(29)27-17-6-7-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365309
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H29BN4O3S/c1-16-7-6-8-19(11-16)31-25(33)32-20-9-10-22-17(12-20)13-23(36-22)21-14-18(15-30-24(21)29)28-34-26(2,3)27(4,5)35-28/h6-15H,1-5H3,(H2,29,30)(H2,31,32,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364995
PNG
(US9868726, Example 12 | methyl 6-amino-5-[5-({[(3-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H16ClFN4O3S/c1-31-21(29)12-7-15(20(25)26-10-12)19-8-11-6-13(3-5-18(11)32-19)27-22(30)28-14-2-4-17(24)16(23)9-14/h2-10H,1H3,(H2,25,26)(H2,27,28,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365216
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364990
PNG
(US9868726, Example 8 | methyl 6-amino-5-{5-[({[2- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16F4N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-14(3-5-18(11)35-19)30-22(33)31-17-9-13(23(25,26)27)2-4-16(17)24/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365357
PNG
(1-{4-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C25H28BFN4O3/c1-15-6-11-20(27)21(12-15)31-23(32)30-18-9-7-16(8-10-18)19-13-17(14-29-22(19)28)26-33-24(2,3)25(4,5)34-26/h6-14H,1-5H3,(H2,28,29)(H2,30,31,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365338
PNG
(US9868726, Example 43 | methyl 6-amino-5-{5-[(3- c...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365356
PNG
(US9868726, Example 61 | [6-amino-5-(4-{[(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C19H18BFN4O3/c1-11-2-7-16(21)17(8-11)25-19(26)24-14-5-3-12(4-6-14)15-9-13(20(27)28)10-23-18(15)22/h2-10,27-28H,1H3,(H2,22,23)(H2,24,25,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365335
PNG
(US9868726, Example 40 | methyl 6-amino-5-{5-[(3- m...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H19N3O3S/c1-13-4-3-5-14(8-13)22(27)26-17-6-7-19-15(9-17)11-20(30-19)18-10-16(23(28)29-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H,26,27)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365217
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H28BFN4O3S/c1-15-6-8-20(29)21(10-15)33-25(34)32-18-7-9-22-16(11-18)12-23(37-22)19-13-17(14-31-24(19)30)28-35-26(2,3)27(4,5)36-28/h6-14H,1-5H3,(H2,30,31)(H2,32,33,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364995
PNG
(US9868726, Example 12 | methyl 6-amino-5-[5-({[(3-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H16ClFN4O3S/c1-31-21(29)12-7-15(20(25)26-10-12)19-8-11-6-13(3-5-18(11)32-19)27-22(30)28-14-2-4-17(24)16(23)9-14/h2-10H,1H3,(H2,25,26)(H2,27,28,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365354
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H30FN5O5S/c1-17-4-9-22(27)23(14-17)31-26(36)30-20-7-5-18(6-8-20)21-15-19(16-29-24(21)28)25(35)32-38(37,12-2-10-33)13-3-11-34/h4-9,14-16,33-34H,2-3,10-13H2,1H3,(H2,28,29)(H2,30,31,36)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364998
PNG
(US9868726, Example 15 | methyl 6-amino-5-{5- [(ani...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C22H18N4O3S/c1-29-21(27)14-10-17(20(23)24-12-14)19-11-13-9-16(7-8-18(13)30-19)26-22(28)25-15-5-3-2-4-6-15/h2-12H,1H3,(H2,23,24)(H2,25,26,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365371
PNG
(US9868726, Example 76 | methyl 6-amino-5-{4- [(phe...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C20H18N4O3/c1-27-19(25)14-11-17(18(21)22-12-14)13-7-9-16(10-8-13)24-20(26)23-15-5-3-2-4-6-15/h2-12H,1H3,(H2,21,22)(H2,23,24,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365339
PNG
(US9868726, Example 44 | methyl 6-amino-5-(5-{[2- f...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H15F4N3O3S/c1-33-22(32)12-7-16(20(28)29-10-12)19-8-11-6-14(3-5-18(11)34-19)30-21(31)15-9-13(23(25,26)27)2-4-17(15)24/h2-10H,1H3,(H2,28,29)(H,30,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365326
PNG
(US9868726, Example 39 | methyl 6-amino-5-{5-[(3- m...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3occc3C)ccc2s1
Show InChI InChI=1S/C21H17N3O4S/c1-11-5-6-28-18(11)20(25)24-14-3-4-16-12(7-14)9-17(29-16)15-8-13(21(26)27-2)10-23-19(15)22/h3-10H,1-2H3,(H2,22,23)(H,24,25)
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n/an/a 31n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365315
PNG
(6-amino-5-(5-{[4-chloro-3- (trifluoromethyl)benzoy...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-23(34)14-8-16(21(29)30-11-14)20-10-13-7-15(4-6-19(13)36-20)31-22(33)12-3-5-18(25)17(9-12)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365366
PNG
(US9868726, Example 71 | dimethyl 5,5'-(N-{[6-amino...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C32H38FN5O7S/c1-21-10-15-26(33)27(18-21)37-32(42)36-24-13-11-22(12-14-24)25-19-23(20-35-30(25)34)31(41)38-46(43,16-6-4-8-28(39)44-2)17-7-5-9-29(40)45-3/h10-15,18-20H,4-9,16-17H2,1-3H3,(H2,34,35)(H2,36,37,42)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365006
PNG
(6-amino-5-[5-({[(3- methylphenyl)amino]carbonyl} a...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(N)=O)c1
Show InChI InChI=1S/C22H19N5O2S/c1-12-3-2-4-15(7-12)26-22(29)27-16-5-6-18-13(8-16)10-19(30-18)17-9-14(21(24)28)11-25-20(17)23/h2-11H,1H3,(H2,23,25)(H2,24,28)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365315
PNG
(6-amino-5-(5-{[4-chloro-3- (trifluoromethyl)benzoy...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-23(34)14-8-16(21(29)30-11-14)20-10-13-7-15(4-6-19(13)36-20)31-22(33)12-3-5-18(25)17(9-12)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365307
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C26H25BClFN4O3S/c1-25(2)26(3,4)36-27(35-25)15-11-18(23(30)31-13-15)22-10-14-9-16(6-8-21(14)37-22)32-24(34)33-17-5-7-20(29)19(28)12-17/h5-13H,1-4H3,(H2,30,31)(H2,32,33,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365336
PNG
(US9868726, Example 41 | methyl 6-amino-5-{5-[(2- f...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H18FN3O3S/c1-12-3-5-18(24)16(7-12)22(28)27-15-4-6-19-13(8-15)10-20(31-19)17-9-14(23(29)30-2)11-26-21(17)25/h3-11H,1-2H3,(H2,25,26)(H,27,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365001
PNG
(6-amino-5-[5-({[(2-fluoro-5- methylphenyl)amino]ca...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(O)=O)c1
Show InChI InChI=1S/C22H17FN4O3S/c1-11-2-4-16(23)17(6-11)27-22(30)26-14-3-5-18-12(7-14)9-19(31-18)15-8-13(21(28)29)10-25-20(15)24/h2-10H,1H3,(H2,24,25)(H,28,29)(H2,26,27,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365000
PNG
(6-amino-5-[5-({[(3-chloro-4- fluorophenyl)amino]ca...)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1)C(O)=O
Show InChI InChI=1S/C21H14ClFN4O3S/c22-15-8-13(1-3-16(15)23)27-21(30)26-12-2-4-17-10(5-12)7-18(31-17)14-6-11(20(28)29)9-25-19(14)24/h1-9H,(H2,24,25)(H,28,29)(H2,26,27,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365367
PNG
(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C32H36F3N5O7S/c1-46-27(41)10-3-5-16-48(45,17-6-4-11-28(42)47-2)40-30(43)22-18-26(29(36)37-20-22)21-12-14-24(15-13-21)38-31(44)39-25-9-7-8-23(19-25)32(33,34)35/h7-9,12-15,18-20H,3-6,10-11,16-17H2,1-2H3,(H2,36,37)(H2,38,39,44)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365308
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C28H31BN4O3S/c1-6-17-8-7-9-20(12-17)32-26(34)33-21-10-11-23-18(13-21)14-24(37-23)22-15-19(16-31-25(22)30)29-35-27(2,3)28(4,5)36-29/h7-16H,6H2,1-5H3,(H2,30,31)(H2,32,33,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365312
PNG
(US9868726, Example 31 | {6-amino-5-[5-({[(3- methy...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C21H19BN4O3S/c1-12-3-2-4-15(7-12)25-21(27)26-16-5-6-18-13(8-16)9-19(30-18)17-10-14(22(28)29)11-24-20(17)23/h2-11,28-29H,1H3,(H2,23,24)(H2,25,26,27)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364977
PNG
(6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzothi...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C23H21N5O3S2/c1-33(2,31)28-22(29)15-11-18(21(24)25-13-15)20-12-14-10-17(8-9-19(14)32-20)27-23(30)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364991
PNG
(US9868726, Example 9 | methyl 6-amino-5-{5-[({[4- ...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H16ClF3N4O3S/c1-34-21(32)12-7-15(20(28)29-10-12)19-8-11-6-13(3-5-18(11)35-19)30-22(33)31-14-2-4-17(24)16(9-14)23(25,26)27/h2-10H,1H3,(H2,28,29)(H2,30,31,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364996
PNG
(US9868726, Example 13 | methyl 6-amino-5-[5-({[(4-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(C)cc3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S/c1-13-3-5-16(6-4-13)26-23(29)27-17-7-8-19-14(9-17)11-20(31-19)18-10-15(22(28)30-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365318
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H21FN4O3S2/c1-13-4-6-19(25)17(8-13)24(31)28-16-5-7-20-14(9-16)11-21(33-20)18-10-15(12-27-22(18)26)23(30)29-34(2,3)32/h4-12H,1-3H3,(H2,26,27)(H,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365320
PNG
(6-amino-5-[5-(benzoylamino)- 1-benzothien-2-yl]-N...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C23H20N4O3S2/c1-32(2,30)27-23(29)16-11-18(21(24)25-13-16)20-12-15-10-17(8-9-19(15)31-20)26-22(28)14-6-4-3-5-7-14/h3-13H,1-2H3,(H2,24,25)(H,26,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365357
PNG
(1-{4-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C25H28BFN4O3/c1-15-6-11-20(27)21(12-15)31-23(32)30-18-9-7-16(8-10-18)19-13-17(14-29-22(19)28)26-33-24(2,3)25(4,5)34-26/h6-14H,1-5H3,(H2,28,29)(H2,30,31,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365321
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H22N4O3S2/c1-14-5-4-6-15(9-14)23(29)27-18-7-8-20-16(10-18)12-21(32-20)19-11-17(13-26-22(19)25)24(30)28-33(2,3)31/h4-13H,1-3H3,(H2,25,26)(H,27,29)
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n/an/a 53n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365309
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B2OC(C)(C)C(C)(C)O2)c1
Show InChI InChI=1S/C27H29BN4O3S/c1-16-7-6-8-19(11-16)31-25(33)32-20-9-10-22-17(12-20)13-23(36-22)21-14-18(15-30-24(21)29)28-34-26(2,3)27(4,5)35-28/h6-15H,1-5H3,(H2,29,30)(H2,31,32,33)
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n/an/a 54n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365359
PNG
(US9868726, Example 64 | dimethyl {6-amino-5-[4-({[...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H20F3N4O4P/c1-31-33(30,32-2)17-11-18(19(25)26-12-17)13-6-8-15(9-7-13)27-20(29)28-16-5-3-4-14(10-16)21(22,23)24/h3-12H,1-2H3,(H2,25,26)(H2,27,28,29)
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n/an/a 57n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365335
PNG
(US9868726, Example 40 | methyl 6-amino-5-{5-[(3- m...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C23H19N3O3S/c1-13-4-3-5-14(8-13)22(27)26-17-6-7-19-15(9-17)11-20(30-19)18-10-16(23(28)29-2)12-25-21(18)24/h3-12H,1-2H3,(H2,24,25)(H,26,27)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365356
PNG
(US9868726, Example 61 | [6-amino-5-(4-{[(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C19H18BFN4O3/c1-11-2-7-16(21)17(8-11)25-19(26)24-14-5-3-12(4-6-14)15-9-13(20(27)28)10-23-18(15)22/h2-10,27-28H,1H3,(H2,22,23)(H2,24,25,26)
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n/an/a 58n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365326
PNG
(US9868726, Example 39 | methyl 6-amino-5-{5-[(3- m...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3occc3C)ccc2s1
Show InChI InChI=1S/C21H17N3O4S/c1-11-5-6-28-18(11)20(25)24-14-3-4-16-12(7-14)9-17(29-16)15-8-13(21(26)27-2)10-23-19(15)22/h3-10H,1-2H3,(H2,22,23)(H,24,25)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 69n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM364977
PNG
(6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzothi...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C23H21N5O3S2/c1-33(2,31)28-22(29)15-11-18(21(24)25-13-15)20-12-14-10-17(8-9-19(14)32-20)27-23(30)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,30)
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n/an/a 73n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364997
PNG
(US9868726, Example 14 | methyl 6-amino-5-[5-({[(2-...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3F)ccc2s1
Show InChI InChI=1S/C22H17FN4O3S/c1-30-21(28)13-9-15(20(24)25-11-13)19-10-12-8-14(6-7-18(12)31-19)26-22(29)27-17-5-3-2-4-16(17)23/h2-11H,1H3,(H2,24,25)(H2,26,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365360
PNG
(US9868726, Example 65 | diethyl [6-amino-5-(4-{[(2...)
Show SMILES CCOP(=O)(OCC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C23H26FN4O4P/c1-4-31-33(30,32-5-2)18-13-19(22(25)26-14-18)16-7-9-17(10-8-16)27-23(29)28-21-12-15(3)6-11-20(21)24/h6-14H,4-5H2,1-3H3,(H2,25,26)(H2,27,28,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365364
PNG
(6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda6- s...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H31N5O5S/c1-18-5-2-6-22(15-18)30-26(35)29-21-9-7-19(8-10-21)23-16-20(17-28-24(23)27)25(34)31-37(36,13-3-11-32)14-4-12-33/h2,5-10,15-17,32-33H,3-4,11-14H2,1H3,(H2,27,28)(H2,29,30,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365366
PNG
(US9868726, Example 71 | dimethyl 5,5'-(N-{[6-amino...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C32H38FN5O7S/c1-21-10-15-26(33)27(18-21)37-32(42)36-24-13-11-22(12-14-24)25-19-23(20-35-30(25)34)31(41)38-46(43,16-6-4-8-28(39)44-2)17-7-5-9-29(40)45-3/h10-15,18-20H,4-9,16-17H2,1-3H3,(H2,34,35)(H2,36,37,42)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365312
PNG
(US9868726, Example 31 | {6-amino-5-[5-({[(3- methy...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)B(O)O)c1
Show InChI InChI=1S/C21H19BN4O3S/c1-12-3-2-4-15(7-12)25-21(27)26-16-5-6-18-13(8-16)9-19(30-18)17-10-14(22(28)29)11-24-20(17)23/h2-11,28-29H,1H3,(H2,23,24)(H2,25,26,27)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365360
PNG
(US9868726, Example 65 | diethyl [6-amino-5-(4-{[(2...)
Show SMILES CCOP(=O)(OCC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C23H26FN4O4P/c1-4-31-33(30,32-5-2)18-13-19(22(25)26-14-18)16-7-9-17(10-8-16)27-23(29)28-21-12-15(3)6-11-20(21)24/h6-14H,4-5H2,1-3H3,(H2,25,26)(H2,27,28,29)
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n/an/a 99n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365354
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1
Show InChI InChI=1S/C26H30FN5O5S/c1-17-4-9-22(27)23(14-17)31-26(36)30-20-7-5-18(6-8-20)21-15-19(16-29-24(21)28)25(35)32-38(37,12-2-10-33)13-3-11-34/h4-9,14-16,33-34H,2-3,10-13H2,1H3,(H2,28,29)(H2,30,31,36)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365361
PNG
(US9868726, Example 66 | dimethyl {6-amino-5-[4-({[...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H19F4N4O4P/c1-32-34(31,33-2)15-10-16(19(26)27-11-15)12-3-6-14(7-4-12)28-20(30)29-18-9-13(21(23,24)25)5-8-17(18)22/h3-11H,1-2H3,(H2,26,27)(H2,28,29,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365008
PNG
(US9868726, Example 21 | methyl 4-[({6-amino-5-[5-(...)
Show SMILES COC(=O)CCCNC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C27H27N5O4S/c1-16-5-3-6-19(11-16)31-27(35)32-20-8-9-22-17(12-20)14-23(37-22)21-13-18(15-30-25(21)28)26(34)29-10-4-7-24(33)36-2/h3,5-6,8-9,11-15H,4,7,10H2,1-2H3,(H2,28,30)(H,29,34)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365005
PNG
(6-amino-5-[5-({[(3- methylphenyl)amino]carbonyl} a...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(O)=O)c1
Show InChI InChI=1S/C22H18N4O3S/c1-12-3-2-4-15(7-12)25-22(29)26-16-5-6-18-13(8-16)10-19(30-18)17-9-14(21(27)28)11-24-20(17)23/h2-11H,1H3,(H2,23,24)(H,27,28)(H2,25,26,29)
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n/an/a 120n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365322
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)13-8-17(21(29)30-11-13)20-9-12-7-15(4-6-19(12)36-20)31-23(34)16-10-14(24(26,27)28)3-5-18(16)25/h3-11H,1-2H3,(H2,29,30)(H,31,34)
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n/an/a 128n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365311
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C26H27BN4O3S/c1-25(2)26(3,4)34-27(33-25)17-14-20(23(28)29-15-17)22-13-16-12-19(10-11-21(16)35-22)31-24(32)30-18-8-6-5-7-9-18/h5-15H,1-4H3,(H2,28,29)(H2,30,31,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365321
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H22N4O3S2/c1-14-5-4-6-15(9-14)23(29)27-18-7-8-20-16(10-18)12-21(32-20)19-11-17(13-26-22(19)25)24(30)28-33(2,3)31/h4-13H,1-3H3,(H2,25,26)(H,27,29)
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n/an/a 131n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365011
PNG
(US9868726, Example 22 | methyl 6-[({6-amino-5-[5-(...)
Show SMILES COC(=O)CCCCCNC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cccc(C)c3)ccc2s1
Show InChI InChI=1S/C29H31N5O4S/c1-18-7-6-8-21(13-18)33-29(37)34-22-10-11-24-19(14-22)16-25(39-24)23-15-20(17-32-27(23)30)28(36)31-12-5-3-4-9-26(35)38-2/h6-8,10-11,13-17H,3-5,9,12H2,1-2H3,(H2,30,32)(H,31,36)(H2,33,34,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365362
PNG
(US9868726, Example 67 | dimethyl [6-amino-5-(4-{[(...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cc(C)ccc2F)cc1
Show InChI InChI=1S/C21H22FN4O4P/c1-13-4-9-18(22)19(10-13)26-21(27)25-15-7-5-14(6-8-15)17-11-16(12-24-20(17)23)31(28,29-2)30-3/h4-12H,1-3H3,(H2,23,24)(H2,25,26,27)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM364998
PNG
(US9868726, Example 15 | methyl 6-amino-5-{5- [(ani...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C22H18N4O3S/c1-29-21(27)14-10-17(20(23)24-12-14)19-11-13-9-16(7-8-18(13)30-19)26-22(28)25-15-5-3-2-4-6-15/h2-12H,1H3,(H2,23,24)(H2,25,26,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365313
PNG
((6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzoth...)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1)B(O)O
Show InChI InChI=1S/C20H17BN4O3S/c22-19-16(10-13(11-23-19)21(27)28)18-9-12-8-15(6-7-17(12)29-18)25-20(26)24-14-4-2-1-3-5-14/h1-11,27-28H,(H2,22,23)(H2,24,25,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365365
PNG
(US9868726, Example 70 | dimethyl 5,5'-(N-{[6-amino...)
Show SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C32H39N5O7S/c1-22-9-8-10-26(19-22)36-32(41)35-25-15-13-23(14-16-25)27-20-24(21-34-30(27)33)31(40)37-45(42,17-6-4-11-28(38)43-2)18-7-5-12-29(39)44-3/h8-10,13-16,19-21H,4-7,11-12,17-18H2,1-3H3,(H2,33,34)(H2,35,36,41)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365322
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)13-8-17(21(29)30-11-13)20-9-12-7-15(4-6-19(12)36-20)31-23(34)16-10-14(24(26,27)28)3-5-18(16)25/h3-11H,1-2H3,(H2,29,30)(H,31,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365336
PNG
(US9868726, Example 41 | methyl 6-amino-5-{5-[(2- f...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(C)ccc3F)ccc2s1
Show InChI InChI=1S/C23H18FN3O3S/c1-12-3-5-18(24)16(7-12)22(28)27-15-4-6-19-13(8-15)10-20(31-19)17-9-14(23(29)30-2)11-26-21(17)25/h3-11H,1-2H3,(H2,25,26)(H,27,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365358
PNG
(1-{4-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C24H27BN4O3/c1-23(2)24(3,4)32-25(31-23)17-14-20(21(26)27-15-17)16-10-12-19(13-11-16)29-22(30)28-18-8-6-5-7-9-18/h5-15H,1-4H3,(H2,26,27)(H2,28,29,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365337
PNG
(6-amino-5-[5-[5 (benzoylamino)-1-benzothien- 2-yl]...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C22H17N3O3S/c1-28-22(27)15-10-17(20(23)24-12-15)19-11-14-9-16(7-8-18(14)29-19)25-21(26)13-5-3-2-4-6-13/h2-12H,1H3,(H2,23,24)(H,25,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365318
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C24H21FN4O3S2/c1-13-4-6-19(25)17(8-13)24(31)28-16-5-7-20-14(9-16)11-21(33-20)18-10-15(12-27-22(18)26)23(30)29-34(2,3)32/h4-12H,1-3H3,(H2,26,27)(H,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365338
PNG
(US9868726, Example 43 | methyl 6-amino-5-{5-[(3- c...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1
Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365311
PNG
(1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...)
Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1
Show InChI InChI=1S/C26H27BN4O3S/c1-25(2)26(3,4)34-27(33-25)17-14-20(23(28)29-15-17)22-13-16-12-19(10-11-21(16)35-22)31-24(32)30-18-8-6-5-7-9-18/h5-15H,1-4H3,(H2,28,29)(H2,30,31,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365313
PNG
((6-amino-5-{5- [(anilinocarbonyl)amino]-1- benzoth...)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccccc3)ccc2s1)B(O)O
Show InChI InChI=1S/C20H17BN4O3S/c22-19-16(10-13(11-23-19)21(27)28)18-9-12-8-15(6-7-17(12)29-18)25-20(26)24-14-4-2-1-3-5-14/h1-11,27-28H,(H2,22,23)(H2,24,25,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM365353
PNG
(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-16(4-6-20(13)36-21)30-23(34)31-17-3-5-19(25)18(10-17)24(26,27)28/h3-12H,1-2H3,(H2,30,31,34)
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ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365005
PNG
(6-amino-5-[5-({[(3- methylphenyl)amino]carbonyl} a...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3sc(cc3c2)-c2cc(cnc2N)C(O)=O)c1
Show InChI InChI=1S/C22H18N4O3S/c1-12-3-2-4-15(7-12)25-22(29)26-16-5-6-18-13(8-16)10-19(30-18)17-9-14(21(27)28)11-24-20(17)23/h2-11H,1H3,(H2,23,24)(H,27,28)(H2,25,26,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365314
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES Cc1ccoc1C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O
Show InChI InChI=1S/C22H20N4O4S2/c1-12-6-7-30-19(12)22(28)25-15-4-5-17-13(8-15)10-18(31-17)16-9-14(11-24-20(16)23)21(27)26-32(2,3)29/h4-11H,1-3H3,(H2,23,24)(H,25,28)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365337
PNG
(6-amino-5-[5-[5 (benzoylamino)-1-benzothien- 2-yl]...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C22H17N3O3S/c1-28-22(27)15-10-17(20(23)24-12-15)19-11-14-9-16(7-8-18(14)29-19)25-21(26)13-5-3-2-4-6-13/h2-12H,1H3,(H2,23,24)(H,25,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))
BDBM365352
PNG
(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 551n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365363
PNG
(US9868726, Example 68 | dimethyl (6-amino-5-{4- [(...)
Show SMILES COP(=O)(OC)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C20H21N4O4P/c1-27-29(26,28-2)17-12-18(19(21)22-13-17)14-8-10-16(11-9-14)24-20(25)23-15-6-4-3-5-7-15/h3-13H,1-2H3,(H2,21,22)(H2,23,24,25)
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n/an/a 891n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365339
PNG
(US9868726, Example 44 | methyl 6-amino-5-(5-{[2- f...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C23H15F4N3O3S/c1-33-22(32)12-7-16(20(28)29-10-12)19-8-11-6-14(3-5-18(11)34-19)30-21(31)15-9-13(23(25,26)27)2-4-17(15)24/h2-10H,1H3,(H2,28,29)(H,30,31)
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n/an/a 930n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365340
PNG
(US9868726, Example 45 | methyl 6-amino-5-{5-[(1- b...)
Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3cc4ccccc4o3)ccc2s1
Show InChI InChI=1S/C24H17N3O4S/c1-30-24(29)15-9-17(22(25)26-12-15)21-11-14-8-16(6-7-20(14)32-21)27-23(28)19-10-13-4-2-3-5-18(13)31-19/h2-12H,1H3,(H2,25,26)(H,27,28)
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n/an/a 936n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365343
PNG
(N-[2-(2-aminopyridin-3-yl)-1- benzothien-5-yl]-3- ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cccnc1N
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-14(10-13)21(25)24-16-7-8-18-15(11-16)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a 1.17E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365343
PNG
(N-[2-(2-aminopyridin-3-yl)-1- benzothien-5-yl]-3- ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc2sc(cc2c1)-c1cccnc1N
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-14(10-13)21(25)24-16-7-8-18-15(11-16)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a 1.28E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365345
PNG
(N-[2-(2-aminopyridin-3-yl)-1- benzothien-5-yl]benz...)
Show SMILES Nc1ncccc1-c1cc2cc(NC(=O)c3ccccc3)ccc2s1
Show InChI InChI=1S/C20H15N3OS/c21-19-16(7-4-10-22-19)18-12-14-11-15(8-9-17(14)25-18)23-20(24)13-5-2-1-3-6-13/h1-12H,(H2,21,22)(H,23,24)
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n/an/a 1.49E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (Human))
BDBM365347
PNG
(2-(2-aminopyridin-3-yl)-N-(3- methylphenyl)-1- ben...)
Show SMILES Cc1cccc(NC(=O)c2ccc3sc(cc3c2)-c2cccnc2N)c1
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-16(10-13)24-21(25)14-7-8-18-15(11-14)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a 3.57E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM365347
PNG
(2-(2-aminopyridin-3-yl)-N-(3- methylphenyl)-1- ben...)
Show SMILES Cc1cccc(NC(=O)c2ccc3sc(cc3c2)-c2cccnc2N)c1
Show InChI InChI=1S/C21H17N3OS/c1-13-4-2-5-16(10-13)24-21(25)14-7-8-18-15(11-14)12-19(26-18)17-6-3-9-23-20(17)22/h2-12H,1H3,(H2,22,23)(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9868726 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%