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Patent code US9868729

Compile Data Set for Download or QSAR

Found 216 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365380
PNG
(US9868729, Example 41)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(N[C@@H]3CC[C@@H](CC3)NC(=O)OCc3ccccc3)n2)cc1
Show InChI InChI=1/C31H38N8O4/c1-21(40)38-15-17-39(18-16-38)26-13-11-24(12-14-26)35-30-33-19-27(28(32)41)29(37-30)34-23-7-9-25(10-8-23)36-31(42)43-20-22-5-3-2-4-6-22/h2-6,11-14,19,23,25H,7-10,15-18,20H2,1H3,(H2,32,41)(H,36,42)(H2,33,34,35,37)/t23-,25+
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n/an/a 5.5n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365510
PNG
(US9868729, Example 229)
Show SMILES CCC(=O)N(C)c1ccc(Nc2ncc(C(N)=O)c(NC3CCC3)n2)cc1
Show InChI InChI=1S/C19H24N6O2/c1-3-16(26)25(2)14-9-7-13(8-10-14)23-19-21-11-15(17(20)27)18(24-19)22-12-5-4-6-12/h7-12H,3-6H2,1-2H3,(H2,20,27)(H2,21,22,23,24)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365521
PNG
(US9868729, Example 241)
Show SMILES NC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1S/C19H24N8O2/c20-16(28)15-11-22-19(25-17(15)23-12-1-2-12)24-13-3-5-14(6-4-13)26-7-9-27(10-8-26)18(21)29/h3-6,11-12H,1-2,7-10H2,(H2,20,28)(H2,21,29)(H2,22,23,24,25)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365546
PNG
(US9868729, Example 268)
Show SMILES CNC(=O)C1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CCC3)n2)cc1
Show InChI InChI=1S/C22H29N7O2/c1-24-21(31)14-9-11-29(12-10-14)17-7-5-16(6-8-17)27-22-25-13-18(19(23)30)20(28-22)26-15-3-2-4-15/h5-8,13-15H,2-4,9-12H2,1H3,(H2,23,30)(H,24,31)(H2,25,26,27,28)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365391
PNG
(2-(4-(4-acetyl-2-carbamoylpiperazin-1-yl)phenylami...)
Show SMILES CC(=O)N1CCN(C(C1)C(N)=O)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1/C21H26N8O3/c1-12(30)28-8-9-29(17(11-28)19(23)32)15-6-4-14(5-7-15)26-21-24-10-16(18(22)31)20(27-21)25-13-2-3-13/h4-7,10,13,17H,2-3,8-9,11H2,1H3,(H2,22,31)(H2,23,32)(H2,24,25,26,27)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365400
PNG
(US9868729, Example 67)
Show SMILES CNC(=O)C1CN(CCN1c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1)C(C)=O
Show InChI InChI=1/C22H28N8O3/c1-13(31)29-9-10-30(18(12-29)21(33)24-2)16-7-5-15(6-8-16)27-22-25-11-17(19(23)32)20(28-22)26-14-3-4-14/h5-8,11,14,18H,3-4,9-10,12H2,1-2H3,(H2,23,32)(H,24,33)(H2,25,26,27,28)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365428
PNG
(US9868729, Example 113)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1S/C21H26N6O2/c1-13(28)27-10-8-15(9-11-27)14-2-4-17(5-3-14)25-21-23-12-18(19(22)29)20(26-21)24-16-6-7-16/h2-5,12,15-16H,6-11H2,1H3,(H2,22,29)(H2,23,24,25,26)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365438
PNG
(US9868729, Example 123)
Show SMILES CC1(CC1)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1S/C22H29N7O/c1-22(8-9-22)29-12-10-28(11-13-29)17-6-4-16(5-7-17)26-21-24-14-18(19(23)30)20(27-21)25-15-2-3-15/h4-7,14-15H,2-3,8-13H2,1H3,(H2,23,30)(H2,24,25,26,27)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365444
PNG
(US9868729, Example 130)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCNCC2)nc1NC1CCC1
Show InChI InChI=1S/C19H25N7O/c20-17(27)16-12-22-19(25-18(16)23-13-2-1-3-13)24-14-4-6-15(7-5-14)26-10-8-21-9-11-26/h4-7,12-13,21H,1-3,8-11H2,(H2,20,27)(H2,22,23,24,25)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365487
PNG
(US9868729, Example 203)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NCCO)nc1NC1CC1
Show InChI InChI=1S/C17H20N6O3/c18-14(25)13-9-20-17(23-15(13)21-11-5-6-11)22-12-3-1-10(2-4-12)16(26)19-7-8-24/h1-4,9,11,24H,5-8H2,(H2,18,25)(H,19,26)(H2,20,21,22,23)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365490
PNG
(US9868729, Example 206)
Show SMILES CN(C)C(=O)[C@@H]1CCCN(C1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1/C22H29N7O2/c1-28(2)21(31)14-4-3-11-29(13-14)17-9-7-16(8-10-17)26-22-24-12-18(19(23)30)20(27-22)25-15-5-6-15/h7-10,12,14-15H,3-6,11,13H2,1-2H3,(H2,23,30)(H2,24,25,26,27)/t14-/s2
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365519
PNG
(US9868729, Example 239)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCCC(F)(F)C2)nc1NC1CC1
Show InChI InChI=1S/C19H22F2N6O/c20-19(21)8-1-9-27(11-19)14-6-4-13(5-7-14)25-18-23-10-15(16(22)28)17(26-18)24-12-2-3-12/h4-7,10,12H,1-3,8-9,11H2,(H2,22,28)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365531
PNG
(US9868729, Example 252)
Show SMILES NC(=O)c1cnc(Nc2ccc3cn[nH]c3c2)nc1NC1CC1
Show InChI InChI=1S/C15H15N7O/c16-13(23)11-7-17-15(21-14(11)19-9-3-4-9)20-10-2-1-8-6-18-22-12(8)5-10/h1-2,5-7,9H,3-4H2,(H2,16,23)(H,18,22)(H2,17,19,20,21)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM100351
PNG
(US8501944, 373 | US8501944, 376 | US9868729, Examp...)
Show SMILES NC(=O)[C@@H]1CCCN(C1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1/C20H25N7O2/c21-17(28)12-2-1-9-27(11-12)15-7-5-14(6-8-15)25-20-23-10-16(18(22)29)19(26-20)24-13-3-4-13/h5-8,10,12-13H,1-4,9,11H2,(H2,21,28)(H2,22,29)(H2,23,24,25,26)/t12-/s2
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365538
PNG
(US9868729, Example 260)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NC1CCC1
Show InChI InChI=1S/C19H24N6O2/c20-17(26)16-12-21-19(24-18(16)22-13-2-1-3-13)23-14-4-6-15(7-5-14)25-8-10-27-11-9-25/h4-7,12-13H,1-3,8-11H2,(H2,20,26)(H2,21,22,23,24)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365558
PNG
(US9868729, Example 309)
Show SMILES NC(=O)c1cnc(Nc2ccc3NC(=O)Cc3c2)nc1NC1CCC1
Show InChI InChI=1S/C17H18N6O2/c18-15(25)12-8-19-17(23-16(12)20-10-2-1-3-10)21-11-4-5-13-9(6-11)7-14(24)22-13/h4-6,8,10H,1-3,7H2,(H2,18,25)(H,22,24)(H2,19,20,21,23)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365346
PNG
(US9868729, Example 35)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CCC3)n2)cc1Cl
Show InChI InChI=1S/C21H26ClN7O2/c1-13(30)28-7-9-29(10-8-28)18-6-5-15(11-17(18)22)26-21-24-12-16(19(23)31)20(27-21)25-14-3-2-4-14/h5-6,11-12,14H,2-4,7-10H2,1H3,(H2,23,31)(H2,24,25,26,27)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365376
PNG
(US9868729, Example 37)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCN(CC2)C(=O)C2CC2)nc1NC1CC1
Show InChI InChI=1S/C22H27N7O2/c23-19(30)18-13-24-22(27-20(18)25-15-3-4-15)26-16-5-7-17(8-6-16)28-9-11-29(12-10-28)21(31)14-1-2-14/h5-8,13-15H,1-4,9-12H2,(H2,23,30)(H2,24,25,26,27)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365381
PNG
(US9868729, Example 42)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NCC3CCN(CC3)C(=O)OC(C)(C)C)n2)cc1
Show InChI InChI=1S/C28H40N8O4/c1-19(37)34-13-15-35(16-14-34)22-7-5-21(6-8-22)32-26-31-18-23(24(29)38)25(33-26)30-17-20-9-11-36(12-10-20)27(39)40-28(2,3)4/h5-8,18,20H,9-17H2,1-4H3,(H2,29,38)(H2,30,31,32,33)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365416
PNG
(US9868729, Example 100)
Show SMILES Cc1cc(ccc1Nc1ncc(C(N)=O)c(NCC(F)(F)F)n1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C19H24F3N7O3S/c1-12-9-13(28-5-7-29(8-6-28)33(2,31)32)3-4-15(12)26-18-24-10-14(16(23)30)17(27-18)25-11-19(20,21)22/h3-4,9-10H,5-8,11H2,1-2H3,(H2,23,30)(H2,24,25,26,27)
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM100349
PNG
(US8501944, 371 | US9868729, Example 207)
Show SMILES CNC(=O)[C@H]1CCCN(C1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1/C21H27N7O2/c1-23-20(30)13-3-2-10-28(12-13)16-8-6-15(7-9-16)26-21-24-11-17(18(22)29)19(27-21)25-14-4-5-14/h6-9,11,13-14H,2-5,10,12H2,1H3,(H2,22,29)(H,23,30)(H2,24,25,26,27)/t13-/s2
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365500
PNG
(US9868729, Example 216)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)-c2ccnc(N)c2)nc1NC1CC1
Show InChI InChI=1S/C19H19N7O/c20-16-9-12(7-8-22-16)11-1-3-14(4-2-11)25-19-23-10-15(17(21)27)18(26-19)24-13-5-6-13/h1-4,7-10,13H,5-6H2,(H2,20,22)(H2,21,27)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365506
PNG
(US9868729, Example 225)
Show SMILES NC(=O)c1cnc(Nc2ccc3cn[nH]c3c2)nc1NC1CCC1
Show InChI InChI=1S/C16H17N7O/c17-14(24)12-8-18-16(22-15(12)20-10-2-1-3-10)21-11-5-4-9-7-19-23-13(9)6-11/h4-8,10H,1-3H2,(H2,17,24)(H,19,23)(H2,18,20,21,22)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365541
PNG
(US9868729, Example 263)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(F)(F)CC2)nc1NC1CCC1
Show InChI InChI=1S/C20H24F2N6O/c21-20(22)8-10-28(11-9-20)15-6-4-14(5-7-15)26-19-24-12-16(17(23)29)18(27-19)25-13-2-1-3-13/h4-7,12-13H,1-3,8-11H2,(H2,23,29)(H2,24,25,26,27)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365549
PNG
(US9868729, Example 271)
Show SMILES NC(=O)c1cnc(Nc2ccc(N3CCOCC3)c(Cl)c2)nc1NC1CCC1
Show InChI InChI=1S/C19H23ClN6O2/c20-15-10-13(4-5-16(15)26-6-8-28-9-7-26)24-19-22-11-14(17(21)27)18(25-19)23-12-2-1-3-12/h4-5,10-12H,1-3,6-9H2,(H2,21,27)(H2,22,23,24,25)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365562
PNG
(US9868729, Example 323)
Show SMILES NC(=O)c1cnc(Nc2ccc3nn[nH]c3c2)nc1NC1CC1
Show InChI InChI=1S/C14H14N8O/c15-12(23)9-6-16-14(19-13(9)17-7-1-2-7)18-8-3-4-10-11(5-8)21-22-20-10/h3-7H,1-2H2,(H2,15,23)(H,20,21,22)(H2,16,17,18,19)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365215
PNG
(US9868729, Example 1)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CCC3)n2)cc1
Show InChI InChI=1S/C21H27N7O2/c1-14(29)27-9-11-28(12-10-27)17-7-5-16(6-8-17)25-21-23-13-18(19(22)30)20(26-21)24-15-3-2-4-15/h5-8,13,15H,2-4,9-12H2,1H3,(H2,22,30)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365379
PNG
(US9868729, Example 40)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1F
Show InChI InChI=1S/C20H24FN7O2/c1-12(29)27-6-8-28(9-7-27)17-5-4-14(10-16(17)21)25-20-23-11-15(18(22)30)19(26-20)24-13-2-3-13/h4-5,10-11,13H,2-3,6-9H2,1H3,(H2,22,30)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365476
PNG
(US9868729, Example 192)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)-c2cccnc2)nc1NC1CC1
Show InChI InChI=1S/C19H18N6O/c20-17(26)16-11-22-19(25-18(16)23-14-7-8-14)24-15-5-3-12(4-6-15)13-2-1-9-21-10-13/h1-6,9-11,14H,7-8H2,(H2,20,26)(H2,22,23,24,25)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365484
PNG
(US9868729, Example 200)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NC2CCC2)nc1NC1CC1
Show InChI InChI=1S/C19H22N6O2/c20-16(26)15-10-21-19(25-17(15)22-13-8-9-13)24-14-6-4-11(5-7-14)18(27)23-12-2-1-3-12/h4-7,10,12-13H,1-3,8-9H2,(H2,20,26)(H,23,27)(H2,21,22,24,25)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365485
PNG
(US9868729, Example 201)
Show SMILES NCC(=O)[C@@H]1CCCN1c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1/C20H25N7O2/c21-10-17(28)16-2-1-9-27(16)14-7-5-13(6-8-14)25-20-23-11-15(18(22)29)19(26-20)24-12-3-4-12/h5-8,11-12,16H,1-4,9-10,21H2,(H2,22,29)(H2,23,24,25,26)/t16-/s2
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365489
PNG
(US9868729, Example 205)
Show SMILES CNC(=O)[C@@H]1CCCN(C1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1/C21H27N7O2/c1-23-20(30)13-3-2-10-28(12-13)16-8-6-15(7-9-16)26-21-24-11-17(18(22)29)19(27-21)25-14-4-5-14/h6-9,11,13-14H,2-5,10,12H2,1H3,(H2,22,29)(H,23,30)(H2,24,25,26,27)/t13-/s2
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n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365492
PNG
(US9868729, Example 208)
Show SMILES CN(C)C(=O)[C@H]1CCCN(C1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1/C22H29N7O2/c1-28(2)21(31)14-4-3-11-29(13-14)17-9-7-16(8-10-17)26-22-24-12-18(19(23)30)20(27-22)25-15-5-6-15/h7-10,12,14-15H,3-6,11,13H2,1-2H3,(H2,23,30)(H2,24,25,26,27)/t14-/s2
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365507
PNG
(US9868729, Example 226)
Show SMILES COc1ccc(Nc2ncc(C(N)=O)c(NC3CCC3)n2)cc1
Show InChI InChI=1S/C16H19N5O2/c1-23-12-7-5-11(6-8-12)20-16-18-9-13(14(17)22)15(21-16)19-10-3-2-4-10/h5-10H,2-4H2,1H3,(H2,17,22)(H2,18,19,20,21)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365517
PNG
(US9868729, Example 237)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(F)CC2)nc1NC1CC1
Show InChI InChI=1S/C19H23FN6O/c20-12-7-9-26(10-8-12)15-5-3-14(4-6-15)24-19-22-11-16(17(21)27)18(25-19)23-13-1-2-13/h3-6,11-13H,1-2,7-10H2,(H2,21,27)(H2,22,23,24,25)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365522
PNG
(US9868729, Example 242)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(F)(F)CC2)nc1NC1CC1
Show InChI InChI=1S/C19H22F2N6O/c20-19(21)7-9-27(10-8-19)14-5-3-13(4-6-14)25-18-23-11-15(16(22)28)17(26-18)24-12-1-2-12/h3-6,11-12H,1-2,7-10H2,(H2,22,28)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365537
PNG
(US9868729, Example 259)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(F)CC2)nc1NC1CCC1
Show InChI InChI=1S/C20H25FN6O/c21-13-8-10-27(11-9-13)16-6-4-15(5-7-16)25-20-23-12-17(18(22)28)19(26-20)24-14-2-1-3-14/h4-7,12-14H,1-3,8-11H2,(H2,22,28)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365561
PNG
(US9868729, Example 322)
Show SMILES NC(=O)c1cnc(Nc2ccc3nc[nH]c3c2)nc1NC1CC1
Show InChI InChI=1S/C15H15N7O/c16-13(23)10-6-17-15(22-14(10)20-8-1-2-8)21-9-3-4-11-12(5-9)19-7-18-11/h3-8H,1-2H2,(H2,16,23)(H,18,19)(H2,17,20,21,22)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365567
PNG
(US9868729, Example 330)
Show SMILES NC(=O)c1cnc(Nc2ccc3nccn3c2)nc1NC1CCC1
Show InChI InChI=1S/C16H17N7O/c17-14(24)12-8-19-16(22-15(12)20-10-2-1-3-10)21-11-4-5-13-18-6-7-23(13)9-11/h4-10H,1-3H2,(H2,17,24)(H2,19,20,21,22)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM100348
PNG
(US8501944, 370 | US8501944, 374 | US9868729, Examp...)
Show SMILES COCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1S/C21H27N7O3/c1-31-13-18(29)28-10-8-27(9-11-28)16-6-4-15(5-7-16)25-21-23-12-17(19(22)30)20(26-21)24-14-2-3-14/h4-7,12,14H,2-3,8-11,13H2,1H3,(H2,22,30)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365384
PNG
(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-4-(piper...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NCC3CCCNC3)n2)cc1
Show InChI InChI=1/C23H32N8O2/c1-16(32)30-9-11-31(12-10-30)19-6-4-18(5-7-19)28-23-27-15-20(21(24)33)22(29-23)26-14-17-3-2-8-25-13-17/h4-7,15,17,25H,2-3,8-14H2,1H3,(H2,24,33)(H2,26,27,28,29)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365417
PNG
(US9868729, Example 101)
Show SMILES CCS(=O)(=O)N1CCN([C@@H](C)C1)c1ccc(Nc2ncc(C(N)=O)c(NCC(F)(F)F)n2)cc1
Show InChI InChI=1S/C20H26F3N7O3S/c1-3-34(32,33)29-8-9-30(13(2)11-29)15-6-4-14(5-7-15)27-19-25-10-16(17(24)31)18(28-19)26-12-20(21,22)23/h4-7,10,13H,3,8-9,11-12H2,1-2H3,(H2,24,31)(H2,25,26,27,28)/t13-/m0/s1
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365421
PNG
(US9868729, Example 106)
Show SMILES CN(C)S(=O)(=O)c1ccc(Nc2ncc(C(N)=O)c(NC3CCC3)n2)cc1
Show InChI InChI=1S/C17H22N6O3S/c1-23(2)27(25,26)13-8-6-12(7-9-13)21-17-19-10-14(15(18)24)16(22-17)20-11-4-3-5-11/h6-11H,3-5H2,1-2H3,(H2,18,24)(H2,19,20,21,22)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365422
PNG
(US9868729, Example 107)
Show SMILES COC(=O)N(C)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1S/C17H20N6O3/c1-23(17(25)26-2)12-7-5-11(6-8-12)21-16-19-9-13(14(18)24)15(22-16)20-10-3-4-10/h5-10H,3-4H2,1-2H3,(H2,18,24)(H2,19,20,21,22)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365432
PNG
(US9868729, Example 117)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCN(CC2)S(=O)(=O)C2CC2)nc1NC1CC1
Show InChI InChI=1S/C21H27N7O3S/c22-19(29)18-13-23-21(26-20(18)24-14-1-2-14)25-15-3-5-16(6-4-15)27-9-11-28(12-10-27)32(30,31)17-7-8-17/h3-6,13-14,17H,1-2,7-12H2,(H2,22,29)(H2,23,24,25,26)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365449
PNG
(US9868729, Example 138)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)no1
Show InChI InChI=1S/C18H19N7O4S/c1-10-8-15(24-29-10)25-30(27,28)13-6-4-12(5-7-13)22-18-20-9-14(16(19)26)17(23-18)21-11-2-3-11/h4-9,11H,2-3H2,1H3,(H2,19,26)(H,24,25)(H2,20,21,22,23)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365459
PNG
(US9868729, Example 174)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCN(CCO)CC2)nc1NC1CC1
Show InChI InChI=1S/C20H27N7O2/c21-18(29)17-13-22-20(25-19(17)23-14-1-2-14)24-15-3-5-16(6-4-15)27-9-7-26(8-10-27)11-12-28/h3-6,13-14,28H,1-2,7-12H2,(H2,21,29)(H2,22,23,24,25)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365514
PNG
(US9868729, Example 234)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NC1CC1
Show InChI InChI=1S/C18H22N6O2/c19-16(25)15-11-20-18(23-17(15)21-12-1-2-12)22-13-3-5-14(6-4-13)24-7-9-26-10-8-24/h3-6,11-12H,1-2,7-10H2,(H2,19,25)(H2,20,21,22,23)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365516
PNG
(US9868729, Example 236)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCC(O)CC2)nc1NC1CC1
Show InChI InChI=1S/C19H24N6O2/c20-17(27)16-11-21-19(24-18(16)22-12-1-2-12)23-13-3-5-14(6-4-13)25-9-7-15(26)8-10-25/h3-6,11-12,15,26H,1-2,7-10H2,(H2,20,27)(H2,21,22,23,24)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365518
PNG
(US9868729, Example 238)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
Show InChI InChI=1S/C19H25N7O/c1-25-8-10-26(11-9-25)15-6-4-14(5-7-15)23-19-21-12-16(17(20)27)18(24-19)22-13-2-3-13/h4-7,12-13H,2-3,8-11H2,1H3,(H2,20,27)(H2,21,22,23,24)
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PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%