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Patent code US9873693

Compile Data Set for Download or QSAR

Found 331 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366343
PNG
(US9873693, Compound 271)
Show SMILES Fc1cc(Cn2cccc(C(=O)NCCCCc3c[nH]c4ncccc34)c2=O)cc(F)c1F
Show InChI InChI=1S/C24H21F3N4O2/c25-19-11-15(12-20(26)21(19)27)14-31-10-4-7-18(24(31)33)23(32)29-8-2-1-5-16-13-30-22-17(16)6-3-9-28-22/h3-4,6-7,9-13H,1-2,5,8,14H2,(H,28,30)(H,29,32)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366241
PNG
(US9873693, Compound 164)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc(ccn3)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C26H19F2N5O2/c27-22-6-5-16(11-23(22)28)15-33-10-2-4-20(26(33)35)25(34)32-13-18-12-17(7-9-29-18)21-14-31-24-19(21)3-1-8-30-24/h1-12,14H,13,15H2,(H,30,31)(H,32,34)
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US Patent
n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366190
PNG
(US9873693, Compound 113 | US9873693, Compound 274)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCOc3ccc4[nH]c(=O)[nH]c4c3)c2=O)cc1F
Show InChI InChI=1S/C22H18F2N4O4/c23-16-5-3-13(10-17(16)24)12-28-8-1-2-15(21(28)30)20(29)25-7-9-32-14-4-6-18-19(11-14)27-22(31)26-18/h1-6,8,10-11H,7,9,12H2,(H,25,29)(H2,26,27,31)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366158
PNG
(US9873693, Compound 81)
Show SMILES Oc1ccc(cc1CNC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C27H20F2N4O3/c28-22-7-5-16(11-23(22)29)15-33-10-2-4-20(27(33)36)26(35)32-13-18-12-17(6-8-24(18)34)21-14-31-25-19(21)3-1-9-30-25/h1-12,14,34H,13,15H2,(H,30,31)(H,32,35)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366163
PNG
(US9873693, Compound 86)
Show SMILES CN1CCC(CC1)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C33H31F2N5O3/c1-39-12-8-24(9-13-39)43-25-15-22(14-23(17-25)28-19-37-31-26(28)4-2-10-36-31)18-38-32(41)27-5-3-11-40(33(27)42)20-21-6-7-29(34)30(35)16-21/h2-7,10-11,14-17,19,24H,8-9,12-13,18,20H2,1H3,(H,36,37)(H,38,41)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366167
PNG
(US9873693, Compound 90)
Show SMILES Oc1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C27H20F2N4O3/c28-23-7-6-17(10-24(23)29)15-33-8-2-5-20(27(33)36)26(35)32-12-16-3-1-4-18(9-16)22-14-31-25-21(22)11-19(34)13-30-25/h1-11,13-14,34H,12,15H2,(H,30,31)(H,32,35)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366351
PNG
(US9873693, Compound 279)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCOc3cc4[nH]c(=O)[nH]c4cn3)c2=O)cc1F
Show InChI InChI=1S/C21H17F2N5O4/c22-14-4-3-12(8-15(14)23)11-28-6-1-2-13(20(28)30)19(29)24-5-7-32-18-9-16-17(10-25-18)27-21(31)26-16/h1-4,6,8-10H,5,7,11H2,(H,24,29)(H2,26,27,31)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366122
PNG
(US9873693, Compound 330 | US9873693, Compound 45)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(Br)cc34)c2=O)cc1F
Show InChI InChI=1S/C27H19BrF2N4O2/c28-19-11-21-22(14-32-25(21)31-13-19)18-4-1-3-16(9-18)12-33-26(35)20-5-2-8-34(27(20)36)15-17-6-7-23(29)24(30)10-17/h1-11,13-14H,12,15H2,(H,31,32)(H,33,35)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366124
PNG
(US9873693, Compound 332 | US9873693, Compound 47)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3cccnc3)c2=O)cc1F
Show InChI InChI=1S/C32H23F2N5O2/c33-28-9-8-21(13-29(28)34)19-39-11-3-7-25(32(39)41)31(40)38-15-20-4-1-5-22(12-20)27-18-37-30-26(27)14-24(17-36-30)23-6-2-10-35-16-23/h1-14,16-18H,15,19H2,(H,36,37)(H,38,40)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366259
PNG
(US9873693, Compound 182)
Show SMILES NC(=O)c1cc(cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C27H20F2N6O3/c28-21-6-5-15(9-22(21)29)14-35-8-2-4-19(27(35)38)26(37)33-12-17-10-16(11-23(34-17)24(30)36)20-13-32-25-18(20)3-1-7-31-25/h1-11,13H,12,14H2,(H2,30,36)(H,31,32)(H,33,37)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366263
PNG
(US9873693, Compound 186)
Show SMILES Fc1cc(Cn2cccc(C(=O)NC(COc3ccc4[nH]c(=O)[nH]c4c3)c3ccc(OCc4ccccc4)cc3)c2=O)cc(F)c1F
Show InChI InChI=1/C35H27F3N4O5/c36-27-15-22(16-28(37)32(27)38)18-42-14-4-7-26(34(42)44)33(43)39-31(20-47-25-12-13-29-30(17-25)41-35(45)40-29)23-8-10-24(11-9-23)46-19-21-5-2-1-3-6-21/h1-17,31H,18-20H2,(H,39,43)(H2,40,41,45)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366266
PNG
(US9873693, Compound 189)
Show SMILES CC(=O)Oc1ccc(cc1)C(COc1ccc2[nH]c(=O)[nH]c2c1)NC(=O)c1cccn(Cc2cc(F)c(F)c(F)c2)c1=O
Show InChI InChI=1/C30H23F3N4O6/c1-16(38)43-19-6-4-18(5-7-19)26(15-42-20-8-9-24-25(13-20)36-30(41)35-24)34-28(39)21-3-2-10-37(29(21)40)14-17-11-22(31)27(33)23(32)12-17/h2-13,26H,14-15H2,1H3,(H,34,39)(H2,35,36,41)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366269
PNG
(US9873693, Compound 192)
Show SMILES Fc1ccc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3cccs3)c2=O)cc1F
Show InChI InChI=1/C26H20F2N4O4S/c27-18-7-5-15(11-19(18)28)13-32-9-1-3-17(25(32)34)24(33)29-22(23-4-2-10-37-23)14-36-16-6-8-20-21(12-16)31-26(35)30-20/h1-12,22H,13-14H2,(H,29,33)(H2,30,31,35)/t22-/s2
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366273
PNG
(US9873693, Compound 196)
Show SMILES OCc1cc(cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C27H21F2N5O3/c28-23-6-5-16(9-24(23)29)14-34-8-2-4-21(27(34)37)26(36)32-12-18-10-17(11-19(15-35)33-18)22-13-31-25-20(22)3-1-7-30-25/h1-11,13,35H,12,14-15H2,(H,30,31)(H,32,36)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366372
PNG
(US9873693, Compound 302)
Show SMILES Fc1cccc(Cn2cccc(C(=O)NCc3noc(n3)-c3c[nH]c4ncccc34)c2=O)c1
Show InChI InChI=1S/C23H17FN6O3/c24-15-5-1-4-14(10-15)13-30-9-3-7-17(23(30)32)21(31)27-12-19-28-22(33-29-19)18-11-26-20-16(18)6-2-8-25-20/h1-11H,12-13H2,(H,25,26)(H,27,31)
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US Patent
n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366376
PNG
(US9873693, Compound 306)
Show SMILES NC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ncc(o1)-c1c[nH]c2ncccc12
Show InChI InChI=1/C26H20F2N6O4/c27-18-6-5-14(9-19(18)28)13-34-8-2-4-16(26(34)37)24(36)33-20(10-22(29)35)25-32-12-21(38-25)17-11-31-23-15(17)3-1-7-30-23/h1-9,11-12,20H,10,13H2,(H2,29,35)(H,30,31)(H,33,36)/t20-/s2
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US Patent
n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366377
PNG
(US9873693, Compound 307)
Show SMILES OC(=O)CC[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1nc(co1)-c1c[nH]c2ncccc12
Show InChI InChI=1/C27H21F2N5O5/c28-19-6-5-15(11-20(19)29)13-34-10-2-4-17(27(34)38)25(37)32-21(7-8-23(35)36)26-33-22(14-39-26)18-12-31-24-16(18)3-1-9-30-24/h1-6,9-12,14,21H,7-8,13H2,(H,30,31)(H,32,37)(H,35,36)/t21-/s2
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366378
PNG
(US9873693, Compound 308)
Show SMILES CN(C)C(=O)CCC([H]C(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1nc(cs1)-c1c[nH]c2ncccc12
Show InChI InChI=1/C29H26F2N6O3S/c1-36(2)25(38)10-9-23(28-35-24(16-41-28)20-14-33-26-18(20)5-3-11-32-26)34-27(39)19-6-4-12-37(29(19)40)15-17-7-8-21(30)22(31)13-17/h3-8,11-14,16,23H,9-10,15H2,1-2H3,(H,32,33)(H,34,39)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366128
PNG
(US9873693, Compound 334 | US9873693, Compound 51)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3cccs3)c2=O)cc1F
Show InChI InChI=1S/C31H22F2N4O2S/c32-26-9-8-20(13-27(26)33)18-37-10-2-6-23(31(37)39)30(38)36-15-19-4-1-5-21(12-19)25-17-35-29-24(25)14-22(16-34-29)28-7-3-11-40-28/h1-14,16-17H,15,18H2,(H,34,35)(H,36,38)
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US Patent
n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366386
PNG
(US9873693, Compound 316)
Show SMILES Fc1cc(Cn2cc(Cl)cc(C(=O)NCc3noc(n3)-c3c[nH]c4ncccc34)c2=O)ccc1Cl
Show InChI InChI=1S/C23H15Cl2FN6O3/c24-13-7-15(23(34)32(11-13)10-12-3-4-17(25)18(26)6-12)21(33)29-9-19-30-22(35-31-19)16-8-28-20-14(16)2-1-5-27-20/h1-8,11H,9-10H2,(H,27,28)(H,29,33)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366084
PNG
(US9873693, Compound 7)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3ccc(s3)-c3n[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C24H17F2N5O2S/c25-18-7-5-14(11-19(18)26)13-31-10-2-4-17(24(31)33)23(32)28-12-15-6-8-20(34-15)21-16-3-1-9-27-22(16)30-29-21/h1-11H,12-13H2,(H,28,32)(H,27,29,30)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366202
PNG
(US9873693, Compound 125 | US9873693, Compound 277)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3nnc(o3)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C23H16F2N6O3/c24-17-6-5-13(9-18(17)25)12-31-8-2-4-15(23(31)33)21(32)28-11-19-29-30-22(34-19)16-10-27-20-14(16)3-1-7-26-20/h1-10H,11-12H2,(H,26,27)(H,28,32)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366285
PNG
(US9873693, Compound 208)
Show SMILES FC(F)c1cc(cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C27H19F4N5O2/c28-21-6-5-15(9-22(21)29)14-36-8-2-4-19(27(36)38)26(37)34-12-17-10-16(11-23(35-17)24(30)31)20-13-33-25-18(20)3-1-7-32-25/h1-11,13,24H,12,14H2,(H,32,33)(H,34,37)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366289
PNG
(US9873693, Compound 212)
Show SMILES Fc1cc(Cn2cccc(C(=O)NC\C=C\c3ccc4\C(=C\c5cnc[nH]5)C(=O)Nc4c3)c2=O)cc(F)c1F
Show InChI InChI=1S/C28H20F3N5O3/c29-22-9-17(10-23(30)25(22)31)14-36-8-2-4-20(28(36)39)26(37)33-7-1-3-16-5-6-19-21(12-18-13-32-15-34-18)27(38)35-24(19)11-16/h1-6,8-13,15H,7,14H2,(H,32,34)(H,33,37)(H,35,38)/b3-1+,21-12-
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366392
PNG
(US9873693, Compound 322)
Show SMILES CCC[C@H](COc1ccc2[nH]c(=O)[nH]c2c1)NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O
Show InChI InChI=1/C25H24F2N4O4/c1-2-4-16(14-35-17-7-9-21-22(12-17)30-25(34)29-21)28-23(32)18-5-3-10-31(24(18)33)13-15-6-8-19(26)20(27)11-15/h3,5-12,16H,2,4,13-14H2,1H3,(H,28,32)(H2,29,30,34)/t16-/s2
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366139
PNG
(US9873693, Compound 62)
Show SMILES NC(=O)COc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C29H23F2N5O4/c30-24-6-5-17(11-25(24)31)15-36-8-2-4-22(29(36)39)28(38)35-13-18-9-19(12-20(10-18)40-16-26(32)37)23-14-34-27-21(23)3-1-7-33-27/h1-12,14H,13,15-16H2,(H2,32,37)(H,33,34)(H,35,38)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366098
PNG
(US9873693, Compound 21)
Show SMILES OC(=O)c1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C26H18F2N4O4S/c27-20-5-3-14(8-21(20)28)13-32-7-1-2-17(25(32)34)24(33)31-11-16-4-6-22(37-16)19-12-30-23-18(19)9-15(10-29-23)26(35)36/h1-10,12H,11,13H2,(H,29,30)(H,31,33)(H,35,36)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366314
PNG
(US9873693, Compound 239)
Show SMILES CNC(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C29H23F2N5O3/c1-32-27(37)20-12-22-23(15-34-26(22)33-14-20)19-5-2-4-17(10-19)13-35-28(38)21-6-3-9-36(29(21)39)16-18-7-8-24(30)25(31)11-18/h2-12,14-15H,13,16H2,1H3,(H,32,37)(H,33,34)(H,35,38)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366106
PNG
(US9873693, Compound 29)
Show SMILES CCCNC(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C31H27F2N5O3/c1-2-10-34-29(39)22-14-24-25(17-36-28(24)35-16-22)21-6-3-5-19(12-21)15-37-30(40)23-7-4-11-38(31(23)41)18-20-8-9-26(32)27(33)13-20/h3-9,11-14,16-17H,2,10,15,18H2,1H3,(H,34,39)(H,35,36)(H,37,40)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366108
PNG
(US9873693, Compound 31)
Show SMILES CCNC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
Show InChI InChI=1/C29H25F2N5O3S/c1-2-32-26(37)14-23(25-10-9-24(40-25)20-15-34-27-18(20)5-3-11-33-27)35-28(38)19-6-4-12-36(29(19)39)16-17-7-8-21(30)22(31)13-17/h3-13,15,23H,2,14,16H2,1H3,(H,32,37)(H,33,34)(H,35,38)/t23-/s2
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366140
PNG
(US9873693, Compound 63)
Show SMILES CN(C)C(=O)COc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C31H27F2N5O4/c1-37(2)28(39)18-42-22-12-20(11-21(14-22)25-16-35-29-23(25)5-3-9-34-29)15-36-30(40)24-6-4-10-38(31(24)41)17-19-7-8-26(32)27(33)13-19/h3-14,16H,15,17-18H2,1-2H3,(H,34,35)(H,36,40)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366141
PNG
(US9873693, Compound 64)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c1
Show InChI InChI=1S/C28H21F2N5O2/c29-23-8-6-18(12-24(23)30)15-35-10-2-5-21(28(35)37)27(36)32-14-17-3-1-4-19(11-17)20-7-9-25-22(13-20)26(31)34-16-33-25/h1-13,16H,14-15H2,(H,32,36)(H2,31,33,34)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366224
PNG
(US9873693, Compound 147)
Show SMILES Fc1ccc(cc1)C(COc1ccc2[nH]c(=O)[nH]c2c1)NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O
Show InChI InChI=1/C28H21F3N4O4/c29-18-6-4-17(5-7-18)25(15-39-19-8-10-23-24(13-19)34-28(38)33-23)32-26(36)20-2-1-11-35(27(20)37)14-16-3-9-21(30)22(31)12-16/h1-13,25H,14-15H2,(H,32,36)(H2,33,34,38)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366225
PNG
(US9873693, Compound 148)
Show SMILES Fc1ccc(cc1)[C@@H](COc1ccc2[nH]c(=O)[nH]c2c1)NC(=O)c1cccn(Cc2ccc(cc2)C(F)(F)F)c1=O
Show InChI InChI=1/C29H22F4N4O4/c30-20-9-5-18(6-10-20)25(16-41-21-11-12-23-24(14-21)36-28(40)35-23)34-26(38)22-2-1-13-37(27(22)39)15-17-3-7-19(8-4-17)29(31,32)33/h1-14,25H,15-16H2,(H,34,38)(H2,35,36,40)/t25-/s2
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366187
PNG
(US9873693, Compound 110 | US9873693, Compound 270 ...)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCCCc3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C24H22F2N4O2/c25-20-9-8-16(13-21(20)26)15-30-12-4-7-19(24(30)32)23(31)28-10-2-1-5-17-14-29-22-18(17)6-3-11-27-22/h3-4,6-9,11-14H,1-2,5,10,15H2,(H,27,29)(H,28,31)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366116
PNG
(US9873693, Compound 39)
Show SMILES NC(=O)c1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C26H19F2N5O3S/c27-20-5-3-14(8-21(20)28)13-33-7-1-2-17(26(33)36)25(35)32-11-16-4-6-22(37-16)19-12-31-24-18(19)9-15(10-30-24)23(29)34/h1-10,12H,11,13H2,(H2,29,34)(H,30,31)(H,32,35)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366150
PNG
(US9873693, Compound 73)
Show SMILES COc1ccc(cc1CNC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C28H22F2N4O3/c1-37-25-9-7-18(22-15-32-26-20(22)4-2-10-31-26)13-19(25)14-33-27(35)21-5-3-11-34(28(21)36)16-17-6-8-23(29)24(30)12-17/h2-13,15H,14,16H2,1H3,(H,31,32)(H,33,35)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366155
PNG
(US9873693, Compound 78)
Show SMILES COc1ccc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc1-c1c[nH]c2ncccc12
Show InChI InChI=1S/C28H22F2N4O3/c1-37-25-9-7-17(12-21(25)22-15-32-26-19(22)4-2-10-31-26)14-33-27(35)20-5-3-11-34(28(20)36)16-18-6-8-23(29)24(30)13-18/h2-13,15H,14,16H2,1H3,(H,31,32)(H,33,35)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366328
PNG
(US9873693, Compound 255)
Show SMILES COc1ccnc(NCCC#CCCNC(=O)c2cccn(Cc3ccc(Cl)c(Cl)c3)c2=O)n1
Show InChI InChI=1S/C24H23Cl2N5O3/c1-34-21-10-13-29-24(30-21)28-12-5-3-2-4-11-27-22(32)18-7-6-14-31(23(18)33)16-17-8-9-19(25)20(26)15-17/h6-10,13-15H,4-5,11-12,16H2,1H3,(H,27,32)(H,28,29,30)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366330
PNG
(US9873693, Compound 257)
Show SMILES CCc1ccnc(NCCC#CCCNC(=O)c2cc(Cl)cn(Cc3cccc(Cl)c3)c2=O)n1
Show InChI InChI=1S/C25H25Cl2N5O2/c1-2-21-10-13-30-25(31-21)29-12-6-4-3-5-11-28-23(33)22-15-20(27)17-32(24(22)34)16-18-8-7-9-19(26)14-18/h7-10,13-15,17H,2,5-6,11-12,16H2,1H3,(H,28,33)(H,29,30,31)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366183
PNG
(US9873693, Compound 106 | US9873693, Compound 260)
Show SMILES COc1ccnc(NCCC#CCCNC(=O)c2cc(Cl)cn(C(C)c3ccc(Cl)cc3)c2=O)n1
Show InChI InChI=1/C25H25Cl2N5O3/c1-17(18-7-9-19(26)10-8-18)32-16-20(27)15-21(24(32)34)23(33)28-12-5-3-4-6-13-29-25-30-14-11-22(31-25)35-2/h7-11,14-17H,5-6,12-13H2,1-2H3,(H,28,33)(H,29,30,31)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366335
PNG
(US9873693, Compound 262)
Show SMILES COc1ccnc(NCCC#CCNC(=O)c2cccn(Cc3cccc(Cl)c3)c2=O)n1
Show InChI InChI=1S/C23H22ClN5O3/c1-32-20-10-13-27-23(28-20)26-12-4-2-3-11-25-21(30)19-9-6-14-29(22(19)31)16-17-7-5-8-18(24)15-17/h5-10,13-15H,4,11-12,16H2,1H3,(H,25,30)(H,26,27,28)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366341
PNG
(US9873693, Compound 269)
Show SMILES Clc1ccc(Cn2cccc(C(=O)NCCCCc3c[nH]c4ncccc34)c2=O)cc1Cl
Show InChI InChI=1S/C24H22Cl2N4O2/c25-20-9-8-16(13-21(20)26)15-30-12-4-7-19(24(30)32)23(31)28-10-2-1-5-17-14-29-22-18(17)6-3-11-27-22/h3-4,6-9,11-14H,1-2,5,10,15H2,(H,27,29)(H,28,31)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366240
PNG
(US9873693, Compound 163)
Show SMILES Fc1cc(Cn2cccc(C(=O)NC(COc3ccc4[nH]c(=O)[nH]c4c3)c3cccnc3)c2=O)cc(F)c1F
Show InChI InChI=1/C27H20F3N5O4/c28-19-9-15(10-20(29)24(19)30)13-35-8-2-4-18(26(35)37)25(36)32-23(16-3-1-7-31-12-16)14-39-17-5-6-21-22(11-17)34-27(38)33-21/h1-12,23H,13-14H2,(H,32,36)(H2,33,34,38)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366157
PNG
(US9873693, Compound 80)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)C(F)(F)F)c2=O)cc1F
Show InChI InChI=1S/C28H19F5N4O2/c29-23-7-6-17(10-24(23)30)15-37-8-2-5-20(27(37)39)26(38)36-12-16-3-1-4-18(9-16)22-14-35-25-21(22)11-19(13-34-25)28(31,32)33/h1-11,13-14H,12,15H2,(H,34,35)(H,36,38)
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US Patent
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366165
PNG
(US9873693, Compound 88)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C37H37F2N5O5/c1-37(2,3)49-36(47)43-14-10-26(11-15-43)48-27-17-24(16-25(19-27)30-21-41-33-28(30)6-4-12-40-33)20-42-34(45)29-7-5-13-44(35(29)46)22-23-8-9-31(38)32(39)18-23/h4-9,12-13,16-19,21,26H,10-11,14-15,20,22H2,1-3H3,(H,40,41)(H,42,45)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366120
PNG
(US9873693, Compound 246 | US9873693, Compound 43)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3nnn[nH]3)c2=O)cc1F
Show InChI InChI=1S/C28H20F2N8O2/c29-23-7-6-17(10-24(23)30)15-38-8-2-5-20(28(38)40)27(39)33-12-16-3-1-4-18(9-16)22-14-32-26-21(22)11-19(13-31-26)25-34-36-37-35-25/h1-11,13-14H,12,15H2,(H,31,32)(H,33,39)(H,34,35,36,37)
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366123
PNG
(US9873693, Compound 331 | US9873693, Compound 46)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3ccsc3)c2=O)cc1F
Show InChI InChI=1S/C31H22F2N4O2S/c32-27-7-6-20(12-28(27)33)17-37-9-2-5-24(31(37)39)30(38)36-14-19-3-1-4-21(11-19)26-16-35-29-25(26)13-23(15-34-29)22-8-10-40-18-22/h1-13,15-16,18H,14,17H2,(H,34,35)(H,36,38)
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US Patent
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366125
PNG
(US9873693, Compound 333 | US9873693, Compound 48)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3ccncc3)c2=O)cc1F
Show InChI InChI=1S/C32H23F2N5O2/c33-28-7-6-21(14-29(28)34)19-39-12-2-5-25(32(39)41)31(40)38-16-20-3-1-4-23(13-20)27-18-37-30-26(27)15-24(17-36-30)22-8-10-35-11-9-22/h1-15,17-18H,16,19H2,(H,36,37)(H,38,40)
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US Patent
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Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366267
PNG
(US9873693, Compound 190)
Show SMILES Fc1ccc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3ccsc3)c2=O)cc1F
Show InChI InChI=1/C26H20F2N4O4S/c27-19-5-3-15(10-20(19)28)12-32-8-1-2-18(25(32)34)24(33)29-23(16-7-9-37-14-16)13-36-17-4-6-21-22(11-17)31-26(35)30-21/h1-11,14,23H,12-13H2,(H,29,33)(H2,30,31,35)/t23-/s2
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%