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Patent code US9884843

Compile Data Set for Download or QSAR
Found 140 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282581
PNG
(4-Bromo-5-(3-chloro-5-fluorophenoxy)-2,2-difluoro-...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7BrClF3O4S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(20)14(18,19)24(10,21)22/h1-5,13,20H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282584
PNG
(4-Chloro-5-(3-chloro-5-fluorophenoxy)-2,2-difluoro...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Cl)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7Cl2F3O4S/c15-6-3-7(17)5-8(4-6)23-9-1-2-10-11(12(9)16)13(20)14(18,19)24(10,21)22/h1-5,13,20H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282702
PNG
((R)-3-((4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Show SMILES Cc1cc(Oc2ccc3c([C@@H](O)C(F)(F)S3(=O)=O)c2C(F)F)cc(c1)C#N
Show InChI InChI=1S/C17H11F4NO4S/c1-8-4-9(7-22)6-10(5-8)26-11-2-3-12-14(13(11)16(18)19)15(23)17(20,21)27(12,24)25/h2-6,15-16,23H,1H3/t15-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282572
PNG
((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282689
PNG
(US9884843, Compound 33)
Show SMILES COCCNC1c2c(ccc(Oc3cc(F)cc(F)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H14BrF4NO4S/c1-26-5-4-23-16-14-13(28(24,25)17(16,21)22)3-2-12(15(14)18)27-11-7-9(19)6-10(20)8-11/h2-3,6-8,16,23H,4-5H2,1H3
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282572
PNG
((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282682
PNG
(3-((3-Amino-4-(difluoromethyl)-2,2-difluoro-1,1- d...)
Show SMILES NC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F5N2O3S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15H,23H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282632
PNG
(5-(3-Chloro-5-fluorophenoxy)-4-(difluoromethyl)- 2...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8ClF5O4S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14,22H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282632
PNG
(5-(3-Chloro-5-fluorophenoxy)-4-(difluoromethyl)- 2...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8ClF5O4S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14,22H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282713
PNG
((R)-4-Bromo-5-(3-chloro-5-fluoro-phenoxy)-2,2- dif...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7BrClF3O4S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(20)14(18,19)24(10,21)22/h1-5,13,20H/t13-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282634
PNG
(3-Amino-4-(difluoromethyl)-5-(3,5- difluorophenoxy...)
Show SMILES NC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H9F6NO3S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14H,22H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282686
PNG
(US9884843, Compound 30)
Show SMILES NC1c2c(ccc(Oc3cc(F)cc(F)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H8BrF4NO3S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(20)14(18,19)24(10,21)22/h1-5,13H,20H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282761
PNG
(5-(3-cyano-5-fluoro-phenoxy)-2,2-difluoro-3- hydro...)
Show SMILES CC1(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H9F3N2O4S/c1-16(23)15-12(8-22)13(2-3-14(15)27(24,25)17(16,19)20)26-11-5-9(7-21)4-10(18)6-11/h2-6,23H,1H3
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282598
PNG
(5-(3-Chloro-5-fluorophenoxy)-2,2-difluoro-3- hydro...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C(F)(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7ClF6O4S/c16-6-3-7(17)5-8(4-6)26-9-1-2-10-11(12(9)14(18,19)20)13(23)15(21,22)27(10,24)25/h1-5,13,23H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282656
PNG
(4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- di...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8F6O4S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14,22H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282564
PNG
((R)-3-((4-bromo-2,2-difluoro-3-hydroxy-1,1-dioxido...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7BrF3NO4S/c16-13-10(24-9-4-7(6-20)3-8(17)5-9)1-2-11-12(13)14(21)15(18,19)25(11,22)23/h1-5,14,21H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282768
PNG
((3R)-5-(3-cyano-5-fluoro-phenoxy)-2,2- difluoro-3-...)
Show SMILES C[C@@]1(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H9F3N2O4S/c1-16(23)15-12(8-22)13(2-3-14(15)27(24,25)17(16,19)20)26-11-5-9(7-21)4-10(18)6-11/h2-6,23H,1H3/t16-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282741
PNG
((R)-3-((4-chloro-2,2-difluoro-3-hydroxy-1,1-dioxid...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2Cl)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7ClF3NO4S/c16-13-10(24-9-4-7(6-20)3-8(17)5-9)1-2-11-12(13)14(21)15(18,19)25(11,22)23/h1-5,14,21H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282750
PNG
(US9884843, Compound 94)
Show SMILES OC1c2c(ccc(Oc3cccc4sccc34)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H10F4O4S2/c18-16(19)13-10(25-9-2-1-3-11-8(9)6-7-26-11)4-5-12-14(13)15(22)17(20,21)27(12,23)24/h1-7,15-16,22H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282685
PNG
(3-((4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282597
PNG
(US9884843, Compound 13)
Show SMILES Cc1c2C(O)C(F)(F)S(=O)(=O)c2ccc1Oc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C15H10ClF3O4S/c1-7-11(23-10-5-8(16)4-9(17)6-10)2-3-12-13(7)14(20)15(18,19)24(12,21)22/h2-6,14,20H,1H3
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282740
PNG
((R)-3-((4-bromo-2,2-difluoro-3-hydroxy-1,1-dioxido...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cccc(c3)C#N)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8BrF2NO4S/c16-13-10(23-9-3-1-2-8(6-9)7-19)4-5-11-12(13)14(20)15(17,18)24(11,21)22/h1-6,14,20H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282707
PNG
(US9884843, Compound 51)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=O)(=NC#N)C1(F)F
Show InChI InChI=1S/C16H8F6N2O3S/c17-7-3-8(18)5-9(4-7)27-10-1-2-11-13(12(10)15(19)20)14(25)16(21,22)28(11,26)24-6-23/h1-5,14-15,25H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282746
PNG
((R)-4-(Difluoromethyl)-5-(3,4-difluorophenoxy)-2,2...)
Show SMILES O[C@@H]1c2c(ccc(Oc3ccc(F)c(F)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8F6O4S/c16-7-2-1-6(5-8(7)17)25-9-3-4-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14,22H/t13-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282708
PNG
(4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- di...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=N)(=O)C1(F)F
Show InChI InChI=1S/C15H9F6NO3S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(23)15(20,21)26(10,22)24/h1-5,13-14,22-23H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282711
PNG
((R)-3-Amino-4-(difluoromethyl)-5-(3,5- difluorophe...)
Show SMILES N[C@@H]1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H9F6NO3S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14H,22H2/t13-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282745
PNG
((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cccc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F4NO4S/c17-15(18)12-10(25-9-3-1-2-8(6-9)7-21)4-5-11-13(12)14(22)16(19,20)26(11,23)24/h1-6,14-15,22H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282685
PNG
(3-((4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282756
PNG
(5-(3,5-Difluorophenoxy)-2,2-difluoro-3- hydroxy-3-...)
Show SMILES CC1(O)c2c(ccc(Oc3cc(F)cc(F)c3)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F4NO4S/c1-15(22)14-11(7-21)12(25-10-5-8(17)4-9(18)6-10)2-3-13(14)26(23,24)16(15,19)20/h2-6,22H,1H3
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282583
PNG
(US9884843, Compound 10)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7ClF3NO4S/c16-7-3-8(17)5-9(4-7)24-11-1-2-12-13(10(11)6-20)14(21)15(18,19)25(12,22)23/h1-5,14,21H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282753
PNG
(US9884843, Compound 97)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7F4NO4S/c16-7-3-8(17)5-9(4-7)24-11-1-2-12-13(10(11)6-20)14(21)15(18,19)25(12,22)23/h1-5,14,21H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282570
PNG
((3R)-5-(3-chloro-5-fluoro-phenoxy)-3-hydroxy-1,1- ...)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C#N)c12
Show InChI InChI=1S/C15H9ClFNO4S/c16-8-3-9(17)5-10(4-8)22-13-1-2-14-15(11(13)6-18)12(19)7-23(14,20)21/h1-5,12,19H,7H2/t12-/m0/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282736
PNG
(US9884843, Compound 80)
Show SMILES COc1cc(F)cc(Oc2ccc3c([C@@H](O)C(F)(F)S3(=O)=O)c2Br)c1
Show InChI InChI=1S/C15H10BrF3O5S/c1-23-8-4-7(17)5-9(6-8)24-10-2-3-11-12(13(10)16)14(20)15(18,19)25(11,21)22/h2-6,14,20H,1H3/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282719
PNG
(3-((4-Ethynyl-2,2-difluoro-3-hydroxy-1,1-dioxido- ...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#C)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H8F3NO4S/c1-2-12-13(25-11-6-9(8-21)5-10(18)7-11)3-4-14-15(12)16(22)17(19,20)26(14,23)24/h1,3-7,16,22H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282708
PNG
(4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- di...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=N)(=O)C1(F)F
Show InChI InChI=1S/C15H9F6NO3S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(23)15(20,21)26(10,22)24/h1-5,13-14,22-23H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282715
PNG
(US9884843, Compound 59)
Show SMILES O[C@H]1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7BrClF3O4S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(20)14(18,19)24(10,21)22/h1-5,13,20H/t13-/m0/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282578
PNG
(US9884843, Compound 7)
Show SMILES OC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C#N)c12
Show InChI InChI=1S/C15H9ClFNO4S/c16-8-3-9(17)5-10(4-8)22-13-1-2-14-15(11(13)6-18)12(19)7-23(14,20)21/h1-5,12,19H,7H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282772
PNG
((3R)-4-bromo-5-(3-bromo-5-fluoro-phenoxy)- 2,2-dif...)
Show SMILES N[C@@H]1c2c(ccc(Oc3cc(F)cc(Br)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H8Br2F3NO3S/c15-6-3-7(17)5-8(4-6)23-9-1-2-10-11(12(9)16)13(20)14(18,19)24(10,21)22/h1-5,13H,20H2/t13-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282737
PNG
(US9884843, Compound 81)
Show SMILES COc1cc(F)cc(Oc2ccc3c([C@@H](O)C(F)(F)S3(=O)=O)c2C#N)c1
Show InChI InChI=1S/C16H10F3NO5S/c1-24-9-4-8(17)5-10(6-9)25-12-2-3-13-14(11(12)7-20)15(21)16(18,19)26(13,22)23/h2-6,15,21H,1H3/t15-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282697
PNG
((R)-3-((3-Amino-4-(difluoromethyl)-2,2-difluoro-1,...)
Show SMILES N[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F5N2O3S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15H,23H2/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282747
PNG
(US9884843, Compound 91)
Show SMILES O[C@@H]1c2c(ccc(Oc3ccc(F)c(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-9-2-1-8(5-7(9)6-22)26-10-3-4-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282677
PNG
(US9884843, Compound 24)
Show SMILES OC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C15H10F4O4S/c16-7-3-8(17)5-9(4-7)23-11-1-2-12-13(14(11)15(18)19)10(20)6-24(12,21)22/h1-5,10,15,20H,6H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282754
PNG
(4-Bromo-5-(3,5-difluorophenoxy)-2,2- difluoro-3-hy...)
Show SMILES CC1(O)c2c(ccc(Oc3cc(F)cc(F)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H9BrF4O4S/c1-14(21)12-11(25(22,23)15(14,19)20)3-2-10(13(12)16)24-9-5-7(17)4-8(18)6-9/h2-6,21H,1H3
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282698
PNG
(3-((2,2-Difluoro-4-(fluoromethyl)-3-hydroxy-1,1- d...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2CF)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F4NO4S/c17-6-11-12(25-10-4-8(7-21)3-9(18)5-10)1-2-13-14(11)15(22)16(19,20)26(13,23)24/h1-5,15,22H,6H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282599
PNG
(US9884843, Compound 15)
Show SMILES OC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C(F)F)c12
Show InChI InChI=1S/C15H10ClF3O4S/c16-7-3-8(17)5-9(4-7)23-11-1-2-12-13(14(11)15(18)19)10(20)6-24(12,21)22/h1-5,10,15,20H,6H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282731
PNG
((R)-4-bromo-5-((5-chloropyridin-3-yl)oxy)-2,2- dif...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cncc(Cl)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C13H7BrClF2NO4S/c14-11-8(22-7-3-6(15)4-18-5-7)1-2-9-10(11)12(19)13(16,17)23(9,20)21/h1-5,12,19H/t12-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282734
PNG
((R)-5-((4-Bromo-2,2-difluoro-3-hydroxy-1,1-dioxido...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cncc(c3)C#N)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7BrF2N2O4S/c15-12-9(23-8-3-7(4-18)5-19-6-8)1-2-10-11(12)13(20)14(16,17)24(10,21)22/h1-3,5-6,13,20H/t13-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282693
PNG
(5-((4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-...)
Show SMILES OC1c2c(ccc(Oc3cncc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8F4N2O4S/c16-14(17)11-9(25-8-3-7(4-20)5-21-6-8)1-2-10-12(11)13(22)15(18,19)26(10,23)24/h1-3,5-6,13-14,22H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282724
PNG
(US9884843, Compound 68)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C#N)c12
Show InChI InChI=1S/C15H9F2NO4S/c16-8-3-9(17)5-10(4-8)22-13-1-2-14-15(11(13)6-18)12(19)7-23(14,20)21/h1-5,12,19H,7H2/t12-/m0/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282722
PNG
(US9884843, Compound 66)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2Cl)S(=O)(=NC#N)C1(F)F
Show InChI InChI=1S/C15H7ClF4N2O3S/c16-13-10(25-9-4-7(17)3-8(18)5-9)1-2-11-12(13)14(23)15(19,20)26(11,24)22-6-21/h1-5,14,23H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282591
PNG
(US9884843, Compound 12)
Show SMILES NC1c2cc(Oc3cc(F)cc(Cl)c3)ccc2S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H9ClF3NO3S/c15-7-3-8(16)5-10(4-7)22-9-1-2-12-11(6-9)13(19)14(17,18)23(12,20)21/h1-6,13H,19H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282752
PNG
(US9884843, Compound 96)
Show SMILES CC1(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H10F5NO4S/c1-16(24)14-12(28(25,26)17(16,21)22)3-2-11(13(14)15(19)20)27-10-5-8(7-23)4-9(18)6-10/h2-6,15,24H,1H3
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282691
PNG
(5-((5-Chloropyridin-3-yl)oxy)-4-(difluoromethyl)- ...)
Show SMILES OC1c2c(ccc(Oc3cncc(Cl)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H8ClF4NO4S/c15-6-3-7(5-20-4-6)24-8-1-2-9-11(10(8)13(16)17)12(21)14(18,19)25(9,22)23/h1-5,12-13,21H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282687
PNG
(US9884843, Compound 31 | US9884843, Compound 32)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2Br)S(=N)(=O)C1(F)F
Show InChI InChI=1S/C14H8BrF4NO3S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(21)14(18,19)24(10,20)22/h1-5,13,20-21H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282675
PNG
(4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2- fluo...)
Show SMILES OC1C(F)S(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C15H9F5O4S/c16-6-3-7(17)5-8(4-6)24-9-1-2-10-12(11(9)14(18)19)13(21)15(20)25(10,22)23/h1-5,13-15,21H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282733
PNG
((R)-4-bromo-2,2-difluoro-5-((5-fluoropyridin-3- yl...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cncc(F)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C13H7BrF3NO4S/c14-11-8(22-7-3-6(15)4-18-5-7)1-2-9-10(11)12(19)13(16,17)23(9,20)21/h1-5,12,19H/t12-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282742
PNG
(US9884843, Compound 86)
Show SMILES O[C@@H]1c2c(ccc(Oc3cncc(Cl)c3)c2Cl)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C13H7Cl2F2NO4S/c14-6-3-7(5-18-4-6)22-8-1-2-9-10(11(8)15)12(19)13(16,17)23(9,20)21/h1-5,12,19H/t12-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282721
PNG
(US9884843, Compound 65)
Show SMILES OC1c2c(ccc(OCc3ccccc3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H12F4O4S/c17-15(18)12-10(24-8-9-4-2-1-3-5-9)6-7-11-13(12)14(21)16(19,20)25(11,22)23/h1-7,14-15,21H,8H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282684
PNG
(US9884843, Compound 28)
Show SMILES OC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(c3)C#N)c(C(F)F)c12
Show InChI InChI=1S/C16H10F3NO4S/c17-9-3-8(6-20)4-10(5-9)24-12-1-2-13-14(15(12)16(18)19)11(21)7-25(13,22)23/h1-5,11,16,21H,7H2
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282732
PNG
(US9884843, Compound 76)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cccc(F)c3)c(C#N)c12
Show InChI InChI=1S/C15H10FNO4S/c16-9-2-1-3-10(6-9)21-13-4-5-14-15(11(13)7-17)12(18)8-22(14,19)20/h1-6,12,18H,8H2/t12-/m0/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282743
PNG
(US9884843, Compound 87)
Show SMILES COc1c2C(O)C(F)(F)S(=O)(=O)c2ccc1Oc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C16H10F3NO5S/c1-24-14-11(25-10-5-8(7-20)4-9(17)6-10)2-3-12-13(14)15(21)16(18,19)26(12,22)23/h2-6,15,21H,1H3
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282744
PNG
(US9884843, Compound 88)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7F4NO4S/c16-8-3-7(6-20)4-9(5-8)24-10-1-2-11-12(13(10)17)14(21)15(18,19)25(11,22)23/h1-5,14,21H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282774
PNG
(US9884843, Compound 118)
Show SMILES NC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F3N3O3S/c17-9-3-8(6-20)4-10(5-9)25-12-1-2-13-14(11(12)7-21)15(22)16(18,19)26(13,23)24/h1-5,15H,22H2
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n/an/a 1.23E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282580
PNG
(US9884843, Compound 8)
Show SMILES Fc1cc(Cl)cc(Oc2ccc3c(C(=O)C(F)(F)S3(=O)=O)c2Br)c1
Show InChI InChI=1S/C14H5BrClF3O4S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(20)14(18,19)24(10,21)22/h1-5H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282704
PNG
(US9884843, Compound 48 | US9884843, Compound 49)
Show SMILES OC1CS(=O)(=NC#N)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C16H10F4N2O3S/c17-8-3-9(18)5-10(4-8)25-12-1-2-13-14(15(12)16(19)20)11(23)6-26(13,24)22-7-21/h1-5,11,16,23H,6H2
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n/an/a 1.47E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282641
PNG
(US9884843, Compound 20 | US9884843, Compound 21)
Show SMILES NC1C(F)S(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C15H10F5NO3S/c16-6-3-7(17)5-8(4-6)24-9-1-2-10-12(11(9)14(18)19)13(21)15(20)25(10,22)23/h1-5,13-15H,21H2
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n/an/a 1.54E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282700
PNG
(US9884843, Compound 44)
Show SMILES OC1C(F)S(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C#N)c12
Show InChI InChI=1S/C15H8F3NO4S/c16-7-3-8(17)5-9(4-7)23-11-1-2-12-13(10(11)6-19)14(20)15(18)24(12,21)22/h1-5,14-15,20H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282751
PNG
(US9884843, Compound 95)
Show SMILES OC1c2c(ccc(Oc3cccc4cn[nH]c34)c2C(F)F)S(=O)(=O)C1(F)F
PDB
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282605
PNG
(US9884843, Compound 16)
Show SMILES OC1c2cc(Oc3cc(F)cc(Cl)c3)ccc2S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H8ClF3O4S/c15-7-3-8(16)5-10(4-7)22-9-1-2-12-11(6-9)13(19)14(17,18)23(12,20)21/h1-6,13,19H
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n/an/a 1.88E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282749
PNG
(US9884843, Compound 93)
Show SMILES O[C@@H]1c2c(ccc(OCC3CC3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C13H12F4O4S/c14-12(15)9-7(21-5-6-1-2-6)3-4-8-10(9)11(18)13(16,17)22(8,19)20/h3-4,6,11-12,18H,1-2,5H2/t11-/m1/s1
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n/an/a 1.89E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282710
PNG
(US9884843, Compound 54)
Show SMILES OC1c2c(ccc(OC3CCOCC3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H14F4O5S/c15-13(16)10-8(23-7-3-5-22-6-4-7)1-2-9-11(10)12(19)14(17,18)24(9,20)21/h1-2,7,12-13,19H,3-6H2
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n/an/a 1.92E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282695
PNG
(US9884843, Compound 39)
Show SMILES FC(F)c1c2C(=O)C(F)(F)S(=O)(=O)c2ccc1Oc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C16H6F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,15H
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n/an/a 2.42E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282577
PNG
(US9884843, Compound 6)
Show SMILES OC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(Br)c12
Show InChI InChI=1S/C14H9BrClFO4S/c15-14-11(21-9-4-7(16)3-8(17)5-9)1-2-12-13(14)10(18)6-22(12,19)20/h1-5,10,18H,6H2
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n/an/a 2.44E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282692
PNG
(US9884843, Compound 36)
Show SMILES COCCNC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C19H15F5N2O4S/c1-29-5-4-26-17-16-14(31(27,28)19(17,23)24)3-2-13(15(16)18(21)22)30-12-7-10(9-25)6-11(20)8-12/h2-3,6-8,17-18,26H,4-5H2,1H3
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n/an/a 2.89E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282738
PNG
(US9884843, Compound 82)
Show SMILES Cc1cncc(Oc2ccc3c([C@@H](O)C(F)(F)S3(=O)=O)c2Br)c1
Show InChI InChI=1S/C14H10BrF2NO4S/c1-7-4-8(6-18-5-7)22-9-2-3-10-11(12(9)15)13(19)14(16,17)23(10,20)21/h2-6,13,19H,1H3/t13-/m1/s1
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n/an/a 2.93E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282757
PNG
(US9884843, Compound 101)
Show SMILES OC1(CS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(Br)c12)C(F)(F)F
Show InChI InChI=1S/C15H8BrF5O4S/c16-13-10(25-9-4-7(17)3-8(18)5-9)1-2-11-12(13)14(22,15(19,20)21)6-26(11,23)24/h1-5,22H,6H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282712
PNG
(5-(Difluoromethyl)-6-(3,5-difluorophenoxy)-4-hydro...)
Show SMILES OC1CCS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C16H12F4O4S/c17-8-5-9(18)7-10(6-8)24-12-1-2-13-14(15(12)16(19)20)11(21)3-4-25(13,22)23/h1-2,5-7,11,16,21H,3-4H2
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n/an/a 4.10E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282687
PNG
(US9884843, Compound 31 | US9884843, Compound 32)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2Br)S(=N)(=O)C1(F)F
Show InChI InChI=1S/C14H8BrF4NO3S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(21)14(18,19)24(10,20)22/h1-5,13,20-21H
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n/an/a 4.14E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282755
PNG
(US9884843, Compound 99)
Show SMILES OC1(c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F)C(F)(F)F
Show InChI InChI=1S/C17H7F8NO4S/c18-8-3-7(6-26)4-9(5-8)30-10-1-2-11-13(12(10)14(19)20)15(27,16(21,22)23)17(24,25)31(11,28)29/h1-5,14,27H
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n/an/a 4.40E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282574
PNG
(US9884843, Compound 4)
Show SMILES Fc1cc(Cl)cc(Oc2ccc3c(CCS3(=O)=O)c2Br)c1
Show InChI InChI=1S/C14H9BrClFO3S/c15-14-11-3-4-21(18,19)13(11)2-1-12(14)20-10-6-8(16)5-9(17)7-10/h1-2,5-7H,3-4H2
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n/an/a 4.41E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282758
PNG
(US9884843, Compound 102)
Show SMILES OC1(CS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C#N)c12)C(F)(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-9(18)5-10(4-8)26-12-1-2-13-14(11(12)6-22)15(23,16(19,20)21)7-27(13,24)25/h1-5,23H,7H2
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n/an/a 4.60E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282723
PNG
(US9884843, Compound 67)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(Br)c12
Show InChI InChI=1S/C14H9BrF2O4S/c15-14-11(21-9-4-7(16)3-8(17)5-9)1-2-12-13(14)10(18)6-22(12,19)20/h1-5,10,18H,6H2/t10-/m0/s1
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n/an/a 4.66E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282575
PNG
(US9884843, Compound 5)
Show SMILES Fc1cc(Cl)cc(Oc2ccc3c(CCS3(=O)=O)c2C#N)c1
Show InChI InChI=1S/C15H9ClFNO3S/c16-9-5-10(17)7-11(6-9)21-14-1-2-15-12(13(14)8-18)3-4-22(15,19)20/h1-2,5-7H,3-4H2
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n/an/a 4.86E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282690
PNG
(US9884843, Compound 34)
Show SMILES O[C@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H/t14-/m0/s1
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n/an/a 4.87E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282683
PNG
(US9884843, Compound 27)
Show SMILES FC(F)c1c2C(=N)C(F)S(=O)(=O)c2ccc1Oc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C16H8F4N2O3S/c17-8-3-7(6-21)4-9(5-8)25-10-1-2-11-13(12(10)15(18)19)14(22)16(20)26(11,23)24/h1-5,15-16,22H
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n/an/a 5.84E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282760
PNG
(US9884843, Compound 104)
Show SMILES OC1(CS(=O)(=O)c2ccc(Oc3cc(F)cc(c3)C#N)c(C#N)c12)C(F)(F)F
Show InChI InChI=1S/C17H8F4N2O4S/c18-10-3-9(6-22)4-11(5-10)27-13-1-2-14-15(12(13)7-23)16(24,17(19,20)21)8-28(14,25)26/h1-5,24H,8H2
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n/an/a 6.30E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282714
PNG
(US9884843, Compound 58)
Show SMILES Fc1cc(Cl)cc(Oc2ccc3c(C(=O)C4(CC4)S3(=O)=O)c2Br)c1
Show InChI InChI=1S/C16H9BrClFO4S/c17-14-11(23-10-6-8(18)5-9(19)7-10)1-2-12-13(14)15(20)16(3-4-16)24(12,21)22/h1-2,5-7H,3-4H2
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n/an/a 6.32E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282771
PNG
(US9884843, Compound 115)
Show SMILES CC1(O)c2c(ccc(OC3CC(F)(F)C3)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H11F4NO4S/c1-12(20)11-8(6-19)9(23-7-4-13(15,16)5-7)2-3-10(11)24(21,22)14(12,17)18/h2-3,7,20H,4-5H2,1H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282735
PNG
(US9884843, Compound 79)
Show SMILES CC1(O)c2cc(Oc3cc(F)cc(F)c3)ccc2S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H10F4O4S/c1-14(20)12-7-10(23-11-5-8(16)4-9(17)6-11)2-3-13(12)24(21,22)15(14,18)19/h2-7,20H,1H3
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n/an/a 6.86E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282631
PNG
(US9884843, Compound 17)
Show SMILES NC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C(F)F)c12
Show InChI InChI=1S/C15H11ClF3NO3S/c16-7-3-8(17)5-9(4-7)23-11-1-2-12-13(14(11)15(18)19)10(20)6-24(12,21)22/h1-5,10,15H,6,20H2
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n/an/a 7.88E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282703
PNG
(US9884843, Compound 47)
Show SMILES Fc1cc(Oc2ccc3c(C(=O)C(F)(F)S3(=O)=O)c2Br)cc(c1)C#N
Show InChI InChI=1S/C15H5BrF3NO4S/c16-13-10(24-9-4-7(6-20)3-8(17)5-9)1-2-11-12(13)14(21)15(18,19)25(11,22)23/h1-5H
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n/an/a 9.69E+3n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282730
PNG
(US9884843, Compound 74)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cncc(c3)C#N)c(Br)c12
Show InChI InChI=1S/C14H9BrN2O4S/c15-14-11(21-9-3-8(4-16)5-17-6-9)1-2-12-13(14)10(18)7-22(12,19)20/h1-3,5-6,10,18H,7H2/t10-/m0/s1
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n/an/a 1.02E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282720
PNG
(US9884843, Compound 64)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#CCF)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C18H9F4NO4S/c19-5-1-2-13-14(27-12-7-10(9-23)6-11(20)8-12)3-4-15-16(13)17(24)18(21,22)28(15,25)26/h3-4,6-8,17,24H,5H2
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n/an/a 1.09E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282641
PNG
(US9884843, Compound 20 | US9884843, Compound 21)
Show SMILES NC1C(F)S(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C15H10F5NO3S/c16-6-3-7(17)5-8(4-6)24-9-1-2-10-12(11(9)14(18)19)13(21)15(20)25(10,22)23/h1-5,13-15H,21H2
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n/an/a 1.18E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282726
PNG
(US9884843, Compound 70)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cc(F)cc(c3)C#N)c(C#N)c12
Show InChI InChI=1S/C16H9FN2O4S/c17-10-3-9(6-18)4-11(5-10)23-14-1-2-15-16(12(14)7-19)13(20)8-24(15,21)22/h1-5,13,20H,8H2/t13-/m0/s1
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n/an/a 1.29E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282717
PNG
(US9884843, Compound 61)
Show SMILES O[C@@H]1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C#N)c12
Show InChI InChI=1S/C15H9ClFNO4S/c16-8-3-9(17)5-10(4-8)22-13-1-2-14-15(11(13)6-18)12(19)7-23(14,20)21/h1-5,12,19H,7H2/t12-/m1/s1
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n/an/a 1.29E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282694
PNG
(US9884843, Compound 38)
Show SMILES N[C@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F5N2O3S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15H,23H2/t14-/m0/s1
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n/an/a 1.34E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282725
PNG
(US9884843, Compound 69)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cc(F)cc(c3)C#N)c(Br)c12
Show InChI InChI=1S/C15H9BrFNO4S/c16-15-12(22-10-4-8(6-18)3-9(17)5-10)1-2-13-14(15)11(19)7-23(13,20)21/h1-5,11,19H,7H2/t11-/m0/s1
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n/an/a 1.34E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282729
PNG
(US9884843, Compound 73)
Show SMILES O[C@H]1CS(=O)(=O)c2ccc(Oc3cccc(F)c3)c(Br)c12
Show InChI InChI=1S/C14H10BrFO4S/c15-14-11(20-9-3-1-2-8(16)6-9)4-5-12-13(14)10(17)7-21(12,18)19/h1-6,10,17H,7H2/t10-/m0/s1
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n/an/a 1.37E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282767
PNG
(US9884843, Compound 111)
Show SMILES C[C@]1(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H9F3N2O4S/c1-16(23)15-12(8-22)13(2-3-14(15)27(24,25)17(16,19)20)26-11-5-9(7-21)4-10(18)6-11/h2-6,23H,1H3/t16-/m0/s1
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n/an/a 1.38E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282706
PNG
(US9884843, Compound 50)
Show SMILES OC1CS(=N)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C15H11F4NO3S/c16-7-3-8(17)5-9(4-7)23-11-1-2-12-13(14(11)15(18)19)10(21)6-24(12,20)22/h1-5,10,15,20-21H,6H2
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n/an/a 1.42E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282739
PNG
(US9884843, Compound 83)
Show SMILES COc1cncc(Oc2ccc3c([C@@H](O)C(F)(F)S3(=O)=O)c2Br)c1
Show InChI InChI=1S/C14H10BrF2NO5S/c1-22-7-4-8(6-18-5-7)23-9-2-3-10-11(12(9)15)13(19)14(16,17)24(10,20)21/h2-6,13,19H,1H3/t13-/m1/s1
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n/an/a 1.43E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282748
PNG
(US9884843, Compound 92)
Show SMILES CCOc1ccc2c([C@@H](O)C(F)(F)S2(=O)=O)c1C(F)F
Show InChI InChI=1S/C11H10F4O4S/c1-2-19-5-3-4-6-8(7(5)10(12)13)9(16)11(14,15)20(6,17)18/h3-4,9-10,16H,2H2,1H3/t9-/m1/s1
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n/an/a 1.55E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282769
PNG
(US9884843, Compound 113)
Show SMILES CC1(O)c2c(ccc(OCc3ccccc3)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H13F2NO4S/c1-16(21)15-12(9-20)13(24-10-11-5-3-2-4-6-11)7-8-14(15)25(22,23)17(16,18)19/h2-8,21H,10H2,1H3
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n/an/a 1.67E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282728
PNG
(US9884843, Compound 72)
Show SMILES OC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3)c(Br)c12
Show InChI InChI=1S/C14H9BrF2O4S/c15-14-11(21-9-4-7(16)3-8(17)5-9)1-2-12-13(14)10(18)6-22(12,19)20/h1-5,10,18H,6H2
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n/an/a 1.71E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282704
PNG
(US9884843, Compound 48 | US9884843, Compound 49)
Show SMILES OC1CS(=O)(=NC#N)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c12
Show InChI InChI=1S/C16H10F4N2O3S/c17-8-3-9(18)5-10(4-8)25-12-1-2-13-14(15(12)16(19)20)11(23)6-26(13,24)22-7-21/h1-5,11,16,23H,6H2
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n/an/a 1.74E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282727
PNG
(US9884843, Compound 71)
Show SMILES Fc1cc(F)cc(Oc2ccc3c(c2)C(=O)CS3(=O)=O)c1
Show InChI InChI=1S/C14H8F2O4S/c15-8-3-9(16)5-11(4-8)20-10-1-2-14-12(6-10)13(17)7-21(14,18)19/h1-6H,7H2
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n/an/a 1.76E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282701
PNG
(US9884843, Compound 45)
Show SMILES Cc1cc(Oc2ccc3c(C(=O)C(F)(F)S3(=O)=O)c2C(F)F)cc(c1)C#N
Show InChI InChI=1S/C17H9F4NO4S/c1-8-4-9(7-22)6-10(5-8)26-11-2-3-12-14(13(11)16(18)19)15(23)17(20,21)27(12,24)25/h2-6,16H,1H3
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n/an/a 1.87E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282764
PNG
(US9884843, Compound 108)
Show SMILES OC1CS(=O)(=O)c2ccc(OCC3(CC3)C#N)c(C(F)F)c12
Show InChI InChI=1S/C14H13F2NO4S/c15-13(16)12-9(21-7-14(6-17)3-4-14)1-2-10-11(12)8(18)5-22(10,19)20/h1-2,8,13,18H,3-5,7H2
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n/an/a 1.90E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282718
PNG
(US9884843, Compound 62)
Show SMILES CC1(C)C(O)c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C#N)S1(=O)=O
Show InChI InChI=1S/C17H13ClFNO4S/c1-17(2)16(21)15-12(8-20)13(3-4-14(15)25(17,22)23)24-11-6-9(18)5-10(19)7-11/h3-7,16,21H,1-2H3
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n/an/a 1.96E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282765
PNG
(1-[[4-(difluoromethyl)-2,2-difluoro-3- hydroxy-1,1...)
Show SMILES OC1c2c(ccc(OCC3(CC3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H11F4NO4S/c15-12(16)9-7(23-6-13(5-19)3-4-13)1-2-8-10(9)11(20)14(17,18)24(8,21)22/h1-2,11-12,20H,3-4,6H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282716
PNG
(US9884843, Compound 60)
Show SMILES CC1(C)C(O)c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Br)S1(=O)=O
Show InChI InChI=1S/C16H13BrClFO4S/c1-16(2)15(20)13-12(24(16,21)22)4-3-11(14(13)17)23-10-6-8(18)5-9(19)7-10/h3-7,15,20H,1-2H3
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n/an/a 2.19E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282766
PNG
(2,2-difluoro-3-hydroxy-5-isopropoxy-3- methyl-1,1-...)
Show SMILES CC(C)Oc1ccc2c(c1C#N)C(C)(O)C(F)(F)S2(=O)=O
Show InChI InChI=1S/C13H13F2NO4S/c1-7(2)20-9-4-5-10-11(8(9)6-16)12(3,17)13(14,15)21(10,18)19/h4-5,7,17H,1-3H3
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n/an/a 2.90E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282759
PNG
(US9884843, Compound 103)
Show SMILES OC1(CS(=O)(=O)c2ccc(Oc3cc(F)cc(c3)C#N)c(Br)c12)C(F)(F)F
Show InChI InChI=1S/C16H8BrF4NO4S/c17-14-11(26-10-4-8(6-22)3-9(18)5-10)1-2-12-13(14)15(23,16(19,20)21)7-27(12,24)25/h1-5,23H,7H2
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n/an/a 3.80E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282763
PNG
(US9884843, Compound 107)
Show SMILES C[C@@H]1C(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S1(=O)=O
Show InChI InChI=1S/C17H12F3NO4S/c1-8-16(22)15-13(26(8,23)24)3-2-12(14(15)17(19)20)25-11-5-9(7-21)4-10(18)6-11/h2-6,8,16-17,22H,1H3/t8-,16?/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282762
PNG
(US9884843, Compound 106)
Show SMILES C[C@H]1C(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S1(=O)=O
Show InChI InChI=1S/C17H12F3NO4S/c1-8-16(22)15-13(26(8,23)24)3-2-12(14(15)17(19)20)25-11-5-9(7-21)4-10(18)6-11/h2-6,8,16-17,22H,1H3/t8-,16?/m0/s1
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n/an/a 4.70E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282773
PNG
(US9884843, Compound 117)
Show SMILES NC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(c3)C#N)c(C#N)c12
Show InChI InChI=1S/C16H10FN3O3S/c17-10-3-9(6-18)4-11(5-10)23-14-1-2-15-16(12(14)7-19)13(20)8-24(15,21)22/h1-5,13H,8,20H2
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n/an/a 5.90E+4n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282770
PNG
(US9884843, Compound 114)
Show SMILES OC1(C=C)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C18H9F3N2O4S/c1-2-17(24)16-13(9-23)14(3-4-15(16)28(25,26)18(17,20)21)27-12-6-10(8-22)5-11(19)7-12/h2-7,24H,1H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282632
PNG
(5-(3-Chloro-5-fluorophenoxy)-4-(difluoromethyl)- 2...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8ClF5O4S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14,22H
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n/an/an/an/a 29n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282682
PNG
(3-((3-Amino-4-(difluoromethyl)-2,2-difluoro-1,1- d...)
Show SMILES NC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F5N2O3S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15H,23H2
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n/an/an/an/a 200n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282685
PNG
(3-((4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H
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n/an/an/an/a 14n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282708
PNG
(4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- di...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=N)(=O)C1(F)F
Show InChI InChI=1S/C15H9F6NO3S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(23)15(20,21)26(10,22)24/h1-5,13-14,22-23H
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n/an/an/an/a 90n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282584
PNG
(4-Chloro-5-(3-chloro-5-fluorophenoxy)-2,2-difluoro...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Cl)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7Cl2F3O4S/c15-6-3-7(17)5-8(4-6)23-9-1-2-10-11(12(9)16)13(20)14(18,19)24(10,21)22/h1-5,13,20H
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n/an/an/an/a 125n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282598
PNG
(5-(3-Chloro-5-fluorophenoxy)-2,2-difluoro-3- hydro...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C(F)(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7ClF6O4S/c16-6-3-7(17)5-8(4-6)26-9-1-2-10-11(12(9)14(18,19)20)13(23)15(21,22)27(10,24)25/h1-5,13,23H
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n/an/an/an/a 89n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282572
PNG
((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H/t14-/m1/s1
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n/an/an/an/a 9n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282708
PNG
(4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- di...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=N)(=O)C1(F)F
Show InChI InChI=1S/C15H9F6NO3S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(23)15(20,21)26(10,22)24/h1-5,13-14,22-23H
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n/an/an/an/a 67n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282761
PNG
(5-(3-cyano-5-fluoro-phenoxy)-2,2-difluoro-3- hydro...)
Show SMILES CC1(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C17H9F3N2O4S/c1-16(23)15-12(8-22)13(2-3-14(15)27(24,25)17(16,19)20)26-11-5-9(7-21)4-10(18)6-11/h2-6,23H,1H3
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n/an/an/an/a 48n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282775
PNG
(US9884843, Compound 119)
Show SMILES CO[C@](C(=O)O[C@@H]1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(Br)c12)(c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H16BrClF4O6S/c1-34-23(24(28,29)30,13-5-3-2-4-6-13)22(31)36-18-12-37(32,33)19-8-7-17(21(25)20(18)19)35-16-10-14(26)9-15(27)11-16/h2-11,18H,12H2,1H3/t18-,23+/m1/s1
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n/an/an/an/a 31n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282581
PNG
(4-Bromo-5-(3-chloro-5-fluorophenoxy)-2,2-difluoro-...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7BrClF3O4S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(20)14(18,19)24(10,21)22/h1-5,13,20H
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n/an/an/an/a 65n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282731
PNG
((R)-4-bromo-5-((5-chloropyridin-3-yl)oxy)-2,2- dif...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cncc(Cl)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C13H7BrClF2NO4S/c14-11-8(22-7-3-6(15)4-18-5-7)1-2-9-10(11)12(19)13(16,17)23(9,20)21/h1-5,12,19H/t12-/m1/s1
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n/an/an/an/a 178n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282734
PNG
((R)-5-((4-Bromo-2,2-difluoro-3-hydroxy-1,1-dioxido...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cncc(c3)C#N)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7BrF2N2O4S/c15-12-9(23-8-3-7(4-18)5-19-6-8)1-2-10-11(12)13(20)14(16,17)24(10,21)22/h1-3,5-6,13,20H/t13-/m1/s1
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n/an/an/an/a 330n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282756
PNG
(5-(3,5-Difluorophenoxy)-2,2-difluoro-3- hydroxy-3-...)
Show SMILES CC1(O)c2c(ccc(Oc3cc(F)cc(F)c3)c2C#N)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F4NO4S/c1-15(22)14-11(7-21)12(25-10-5-8(17)4-9(18)6-10)2-3-13(14)26(23,24)16(15,19)20/h2-6,22H,1H3
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n/an/an/an/a 18n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282564
PNG
((R)-3-((4-bromo-2,2-difluoro-3-hydroxy-1,1-dioxido...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7BrF3NO4S/c16-13-10(24-9-4-7(6-20)3-8(17)5-9)1-2-11-12(13)14(21)15(18,19)25(11,22)23/h1-5,14,21H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282656
PNG
(4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- di...)
Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H8F6O4S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14,22H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282713
PNG
((R)-4-Bromo-5-(3-chloro-5-fluoro-phenoxy)-2,2- dif...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2Br)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C14H7BrClF3O4S/c15-12-9(23-8-4-6(16)3-7(17)5-8)1-2-10-11(12)13(20)14(18,19)24(10,21)22/h1-5,13,20H/t13-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282741
PNG
((R)-3-((4-chloro-2,2-difluoro-3-hydroxy-1,1-dioxid...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2Cl)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H7ClF3NO4S/c16-13-10(24-9-4-7(6-20)3-8(17)5-9)1-2-11-12(13)14(21)15(18,19)25(11,22)23/h1-5,14,21H/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282697
PNG
((R)-3-((3-Amino-4-(difluoromethyl)-2,2-difluoro-1,...)
Show SMILES N[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H9F5N2O3S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15H,23H2/t14-/m1/s1
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282572
PNG
((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H/t14-/m1/s1
PDB
MMDB

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n/an/an/an/a 62n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282634
PNG
(3-Amino-4-(difluoromethyl)-5-(3,5- difluorophenoxy...)
Show SMILES NC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=O)(=O)C1(F)F
Show InChI InChI=1S/C15H9F6NO3S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14H,22H2
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n/an/an/an/a 87n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM282578
PNG
(US9884843, Compound 7)
Show SMILES OC1CS(=O)(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C#N)c12
Show InChI InChI=1S/C15H9ClFNO4S/c16-8-3-9(17)5-10(4-8)22-13-1-2-14-15(11(13)6-18)12(19)7-23(14,20)21/h1-5,12,19H,7H2
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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n/an/an/an/a 330n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9884843 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%