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Patent code US9890156

Compile Data Set for Download or QSAR
Found 152 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
PDB

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US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | US9890156, Example 33 | m...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The compounds of the invention assayed in the FGFR Enzymatic Assay after dilution in assay buffer are added to the plate and pre-incubated for 5 to 1...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The compounds of the invention assayed in the FGFR Enzymatic Assay after dilution in assay buffer are added to the plate and pre-incubated for 5 to 1...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | US9890156, Example 33 | m...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357724
PNG
(N-((1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-7-5-6-8-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357714
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O4/c1-5-20(33)28-10-16-6-17-15(9-27-16)13-32(24(34)31(17)12-14-8-29-30(2)11-14)23-21(25)18(35-3)7-19(36-4)22(23)26/h5-9,11H,1,10,12-13H2,2-4H3,(H,28,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357712
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccc(F)c3)C2=O)c1F
Show InChI InChI=1S/C26H23F3N4O4/c1-4-22(34)31-12-18-9-19-16(11-30-18)14-33(25-23(28)20(36-2)10-21(37-3)24(25)29)26(35)32(19)13-15-6-5-7-17(27)8-15/h4-11H,1,12-14H2,2-3H3,(H,31,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357725
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isobuty...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(C)C)C2=O)c1F
Show InChI InChI=1S/C23H26F2N4O4/c1-6-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13(2)3)22-20(24)17(32-4)8-18(33-5)21(22)25/h6-9,13H,1,10-12H2,2-5H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357726
PNG
(N-((1-(cyclobutylmethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-4-20(31)28-11-16-8-17-15(10-27-16)13-30(24(32)29(17)12-14-6-5-7-14)23-21(25)18(33-2)9-19(34-3)22(23)26/h4,8-10,14H,1,5-7,11-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357711
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-isoprop...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C(C)C)C2=O)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-6-18(29)26-10-14-7-15-13(9-25-14)11-27(22(30)28(15)12(2)3)21-19(23)16(31-4)8-17(32-5)20(21)24/h6-9,12H,1,10-11H2,2-5H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | US9890156, Example 33 | m...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357713
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(Cc3cccnc3)C2=O)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-21(33)30-12-17-8-18-16(11-29-17)14-32(25(34)31(18)13-15-6-5-7-28-10-15)24-22(26)19(35-2)9-20(36-3)23(24)27/h4-11H,1,12-14H2,2-3H3,(H,30,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357731
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)S(C)(=O)=O)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O6S/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(38-2)11-21(39-3)24(25)28)26(35)32(19)14-16-6-8-31(9-7-16)40(4,36)37/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
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n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
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US Patent
n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
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n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357719
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCOCC3)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O5/c1-4-20(31)28-12-15-9-17-14(11-27-15)13-29(24(32)30(17)16-5-7-35-8-6-16)23-21(25)18(33-2)10-19(34-3)22(23)26/h4,9-11,16H,1,5-8,12-13H2,2-3H3,(H,28,31)
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n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The compounds of the invention assayed in the FGFR Enzymatic Assay after dilution in assay buffer are added to the plate and pre-incubated for 5 to 1...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357702
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccccc2)c1F
Show InChI InChI=1S/C25H22F2N4O4/c1-4-21(32)29-13-16-10-18-15(12-28-16)14-30(25(33)31(18)17-8-6-5-7-9-17)24-22(26)19(34-2)11-20(35-3)23(24)27/h4-12H,1,13-14H2,2-3H3,(H,29,32)
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n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357704
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N([C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C23H24F2N4O5/c1-4-19(30)27-10-14-7-16-13(9-26-14)11-28(23(31)29(16)15-5-6-34-12-15)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,15H,1,5-6,10-12H2,2-3H3,(H,27,30)/t15-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357706
PNG
(N-((1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxyphe...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC3)C2=O)c1F
Show InChI InChI=1S/C22H22F2N4O4/c1-4-18(29)26-10-13-7-15-12(9-25-13)11-27(22(30)28(15)14-5-6-14)21-19(23)16(31-2)8-17(32-3)20(21)24/h4,7-9,14H,1,5-6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357720
PNG
(N-((7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C22H23F2N3O4/c1-6-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14,2)3)20-18(23)15(30-4)8-16(31-5)19(20)24/h6-9H,1,10-11H2,2-5H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357728
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-met...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C26H31F2N5O4/c1-5-22(34)30-13-18-10-19-17(12-29-18)15-33(25-23(27)20(36-3)11-21(37-4)24(25)28)26(35)32(19)14-16-6-8-31(2)9-7-16/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,30,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357701
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C24H25F2N3O4/c1-4-19(30)28-12-15-9-16-14(11-27-15)13-29(23(31)24(16)7-5-6-8-24)22-20(25)17(32-2)10-18(33-3)21(22)26/h4,9-11H,1,5-8,12-13H2,2-3H3,(H,28,30)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357710
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)F)C2=O)c1F
Show InChI InChI=1S/C21H20F4N4O4/c1-4-17(30)27-8-12-5-13-11(7-26-12)9-29(21(31)28(13)10-16(22)23)20-18(24)14(32-2)6-15(33-3)19(20)25/h4-7,16H,1,8-10H2,2-3H3,(H,27,30)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357715
PNG
((R)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357716
PNG
(N-((1-(cyanomethyl)-3-(2,6-difluoro-3,5-dimethoxyp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC#N)C2=O)c1F
Show InChI InChI=1S/C21H19F2N5O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-24)20-18(22)15(31-2)8-16(32-3)19(20)23/h4,7-9H,1,6,10-11H2,2-3H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357721
PNG
(N-((1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-11-14-8-16-13(10-26-14)12-28(23(31)29(16)15-6-5-7-15)22-20(24)17(32-2)9-18(33-3)21(22)25/h4,8-10,15H,1,5-7,11-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357733
PNG
(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C23H23F2N3O4/c1-5-17(29)27-10-14-12(2)18-13(9-26-14)11-28(22(30)23(18)6-7-23)21-19(24)15(31-3)8-16(32-4)20(21)25/h5,8-9H,1,6-7,10-11H2,2-4H3,(H,27,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357700
PNG
(N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C21H20F2N4O4/c1-4-15(28)25-9-14-24-8-11-10-27(20(29)21(5-6-21)19(11)26-14)18-16(22)12(30-2)7-13(31-3)17(18)23/h4,7-8H,1,5-6,9-10H2,2-3H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357705
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3,3-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C3CC(F)(F)C3)C2=O)c1F
Show InChI InChI=1S/C23H22F4N4O4/c1-4-18(32)29-10-13-5-15-12(9-28-13)11-30(22(33)31(15)14-7-23(26,27)8-14)21-19(24)16(34-2)6-17(35-3)20(21)25/h4-6,9,14H,1,7-8,10-11H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357707
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-meth...)
Show SMILES COCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O5/c1-5-18(29)26-11-14-8-15-13(10-25-14)12-28(22(30)27(15)6-7-31-2)21-19(23)16(32-3)9-17(33-4)20(21)24/h5,8-10H,1,6-7,11-12H2,2-4H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357708
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-p...)
Show SMILES CCCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H24F2N4O4/c1-5-7-27-15-8-14(11-26-18(29)6-2)25-10-13(15)12-28(22(27)30)21-19(23)16(31-3)9-17(32-4)20(21)24/h6,8-10H,2,5,7,11-12H2,1,3-4H3,(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357709
PNG
(N-((1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O4/c1-4-19(30)27-10-15-7-16-14(9-26-15)12-29(23(31)28(16)11-13-5-6-13)22-20(24)17(32-2)8-18(33-3)21(22)25/h4,7-9,13H,1,5-6,10-12H2,2-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357717
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H19F5N4O4/c1-4-16(31)28-8-12-5-13-11(7-27-12)9-29(20(32)30(13)10-21(24,25)26)19-17(22)14(33-2)6-15(34-3)18(19)23/h4-7H,1,8-10H2,2-3H3,(H,28,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357722
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-12-15-9-17-14(11-28-15)13-30(24(33)31(17)16-5-7-27-8-6-16)23-21(25)18(34-2)10-19(35-3)22(23)26/h4-11H,1,12-13H2,2-3H3,(H,29,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357727
PNG
((S)óN-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1/C24H26F2N4O5/c1-4-20(31)28-10-16-7-17-15(9-27-16)12-30(24(32)29(17)11-14-5-6-35-13-14)23-21(25)18(33-2)8-19(34-3)22(23)26/h4,7-9,14H,1,5-6,10-13H2,2-3H3,(H,28,31)/t14-/s2
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357729
PNG
(US10214528, Example 33 | US9890156, Example 33 | m...)
Show SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C27H31F2N5O6/c1-5-22(35)31-13-18-10-19-17(12-30-18)15-34(25-23(28)20(38-2)11-21(39-3)24(25)29)26(36)33(19)14-16-6-8-32(9-7-16)27(37)40-4/h5,10-12,16H,1,6-9,13-15H2,2-4H3,(H,31,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357732
PNG
(N-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357697
PNG
(N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-4-17(28)26-10-13-7-14-12(9-25-13)11-27(21(29)22(14)5-6-22)20-18(23)15(30-2)8-16(31-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,28)
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US Patent


Assay Description
The compounds of the invention assayed in the FGFR Enzymatic Assay after dilution in assay buffer are added to the plate and pre-incubated for 5 to 1...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357698
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2...)
Show SMILES CCN1C(=O)N(Cc2cnc(CNC(=O)C=C)cc12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H22F2N4O4/c1-5-17(28)25-10-13-7-14-12(9-24-13)11-27(21(29)26(14)6-2)20-18(22)15(30-3)8-16(31-4)19(20)23/h5,7-9H,1,6,10-11H2,2-4H3,(H,25,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357699
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-20(32)29-11-15-8-17-14(10-28-15)13-30(24(33)31(17)16-6-5-7-27-12-16)23-21(25)18(34-2)9-19(35-3)22(23)26/h4-10,12H,1,11,13H2,2-3H3,(H,29,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357703
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(c3ccn(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O4/c1-5-19(32)27-11-14-8-15-13(10-26-14)12-30(23(33)31(15)18-6-7-29(2)28-18)22-20(24)16(34-3)9-17(35-4)21(22)25/h5-10H,1,11-12H2,2-4H3,(H,27,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357718
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(C)C2=O)c1F
Show InChI InChI=1S/C20H20F2N4O4/c1-5-16(27)24-9-12-6-13-11(8-23-12)10-26(20(28)25(13)2)19-17(21)14(29-3)7-15(30-4)18(19)22/h5-8H,1,9-10H2,2-4H3,(H,24,27)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM357723
PNG
(N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CCF)C2=O)c1F
Show InChI InChI=1S/C21H21F3N4O4/c1-4-17(29)26-10-13-7-14-12(9-25-13)11-28(21(30)27(14)6-5-22)20-18(23)15(31-2)8-16(32-3)19(20)24/h4,7-9H,1,5-6,10-11H2,2-3H3,(H,26,29)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM357730
PNG
(4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)cc3N(CC3CCN(CC3)C(=O)NC(C)C)C2=O)c1F
Show InChI InChI=1S/C29H36F2N6O5/c1-6-24(38)33-14-20-11-21-19(13-32-20)16-37(27-25(30)22(41-4)12-23(42-5)26(27)31)29(40)36(21)15-18-7-9-35(10-8-18)28(39)34-17(2)3/h6,11-13,17-18H,1,7-10,14-16H2,2-5H3,(H,33,38)(H,34,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9890156 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%