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Patent code US9890166

Compile Data Set for Download or QSAR

Found 638 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380716
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)32-23-21(28-25(32)18-9-11-36-12-10-18)26(35)33(22(23)17-5-7-19(27)8-6-17)20-13-15(3)24-30-29-16(4)34(24)31-20/h5-9,13-14,22H,10-12H2,1-4H3/t22-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380723
PNG
((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Show SMILES CC(C)n1c(C)nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
Show InChI InChI=1S/C22H22ClN7O/c1-11(2)28-13(4)24-18-20(28)19(15-6-8-16(23)9-7-15)29(22(18)31)17-10-12(3)21-26-25-14(5)30(21)27-17/h6-11,19H,1-5H3/t19-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380725
PNG
((R)-6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d]...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1
Show InChI InChI=1S/C28H26ClN7O2/c1-15(2)35-25-23(31-26(35)20-7-6-12-30-27(20)38-5)28(37)36(24(25)17-8-10-18(29)11-9-17)19-13-16(3)22-21(14-19)34(4)33-32-22/h6-15,24H,1-5H3/t24-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380670
PNG
(6-(4-chlorophenyl)-2-cyclopropyl-5-(3,8-dimethyl-[...)
Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(nc(C3CC3)n2C)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN6O/c1-12-10-17(11-29-13(2)26-27-21(12)29)30-19(14-6-8-16(24)9-7-14)20-18(23(30)31)25-22(28(20)3)15-4-5-15/h6-11,15,19H,4-5H2,1-3H3
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380685
PNG
(N-(tert-butyl)-4-(6-(4-chlorophenyl)-5-(3,8-dimeth...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1=CCN(CC1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H37ClN8O2/c1-18(2)40-27-25(34-29(40)22-12-14-38(15-13-22)31(43)35-32(5,6)7)30(42)41(26(27)21-8-10-23(33)11-9-21)24-16-19(3)28-37-36-20(4)39(28)17-24/h8-12,16-18,26H,13-15H2,1-7H3,(H,35,43)
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380695
PNG
((R)-6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d]...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-8,13-15,18,24H,9-12H2,1-4H3/t24-/m1/s1
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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380763
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1S/C28H24ClF2N7O2/c1-14(2)37-22-20(33-25(37)19-6-5-11-32-27(19)40-4)28(39)38(21(22)16-7-9-17(29)10-8-16)18-12-15(3)24-34-35-26(23(30)31)36(24)13-18/h5-14,21,23H,1-4H3/t21-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380768
PNG
((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C27H25ClN8O2/c1-14(2)35-23-21(31-24(35)18-7-6-12-29-26(18)38-5)27(37)36(22(23)16-8-10-17(28)11-9-16)19-13-15(3)20-25(30-19)34(4)33-32-20/h6-14,22H,1-5H3/t22-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380781
PNG
((6R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tri...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1)C1CCOC1
Show InChI InChI=1S/C25H26ClN7O2/c1-13(2)31-22-20(27-24(31)17-9-10-35-12-17)25(34)32(21(22)16-5-7-18(26)8-6-16)19-11-14(3)23-29-28-15(4)33(23)30-19/h5-8,11,13,17,21H,9-10,12H2,1-4H3/t17?,21-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380670
PNG
(6-(4-chlorophenyl)-2-cyclopropyl-5-(3,8-dimethyl-[...)
Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(nc(C3CC3)n2C)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN6O/c1-12-10-17(11-29-13(2)26-27-21(12)29)30-19(14-6-8-16(24)9-7-14)20-18(23(30)31)25-22(28(20)3)15-4-5-15/h6-11,15,19H,4-5H2,1-3H3
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380695
PNG
((R)-6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d]...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-8,13-15,18,24H,9-12H2,1-4H3/t24-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380705
PNG
(6-(4-chlorophenyl)-2-(2,5-dihydrofuran-3-yl)-5-(3-...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(CF)n2c1)C1=CCOC1
Show InChI InChI=1S/C26H24ClFN6O2/c1-14(2)33-23-21(29-25(33)17-8-9-36-13-17)26(35)34(22(23)16-4-6-18(27)7-5-16)19-10-15(3)24-31-30-20(11-28)32(24)12-19/h4-8,10,12,14,22H,9,11,13H2,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380731
PNG
((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-benzo[d]...)
Show SMILES CC(C)n1c(C)nc2[C@H](N(C(=O)c12)c1cc(C)c2nnn(C)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN6O/c1-12(2)29-14(4)25-20-21(15-6-8-16(24)9-7-15)30(23(31)22(20)29)17-10-13(3)19-18(11-17)28(5)27-26-19/h6-12,21H,1-5H3/t21-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380744
PNG
(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)
Show SMILES COc1ncccc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1S/C28H24ClF2N7O2/c1-14(2)37-22-20(33-25(37)19-6-5-11-32-27(19)40-4)28(39)38(21(22)16-7-9-17(29)10-8-16)18-12-15(3)24-34-35-26(23(30)31)36(24)13-18/h5-14,21,23H,1-4H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380770
PNG
(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)33-23-21(29-24(33)17-9-11-36-12-10-17)26(35)34(22(23)16-5-7-18(27)8-6-16)19-13-15(3)20-25(28-19)32(4)31-30-20/h5-9,13-14,22H,10-12H2,1-4H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380632
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CC(C)n1c(C)nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
Show InChI InChI=1S/C22H22ClN7O/c1-11(2)28-13(4)24-18-20(28)19(15-6-8-16(23)9-7-15)29(22(18)31)17-10-12(3)21-26-25-14(5)30(21)27-17/h6-11,19H,1-5H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380694
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H27ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-9,13-15,24H,10-12H2,1-4H3/t24-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380725
PNG
((R)-6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d]...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1
Show InChI InChI=1S/C28H26ClN7O2/c1-15(2)35-25-23(31-26(35)20-7-6-12-30-27(20)38-5)28(37)36(24(25)17-8-10-18(29)11-9-17)19-13-16(3)22-21(14-19)34(4)33-32-22/h6-15,24H,1-5H3/t24-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380750
PNG
(6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]triaz...)
Show SMILES COc1ccc(cn1)-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C27H25ClN8O2/c1-14(2)35-24-22(31-25(35)17-8-11-20(38-5)29-13-17)27(37)36(23(24)16-6-9-18(28)10-7-16)19-12-15(3)21-26(30-19)34(4)33-32-21/h6-14,23H,1-5H3
PDB

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n/an/a 11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380768
PNG
((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C27H25ClN8O2/c1-14(2)35-23-21(31-24(35)18-7-6-12-29-26(18)38-5)27(37)36(22(23)16-8-10-17(28)11-9-16)19-13-15(3)20-25(30-19)34(4)33-32-20/h6-14,22H,1-5H3/t22-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380716
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)32-23-21(28-25(32)18-9-11-36-12-10-18)26(35)33(22(23)17-5-7-19(27)8-6-17)20-13-15(3)24-30-29-16(4)34(24)31-20/h5-9,13-14,22H,10-12H2,1-4H3/t22-/m1/s1
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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380769
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3nnc(C(F)F)n3c2)c(OC)n1
Show InChI InChI=1S/C28H25ClF2N8O3/c1-13(2)38-21-19(33-24(38)18-11-32-28(42-5)34-26(18)41-4)27(40)39(20(21)15-6-8-16(29)9-7-15)17-10-14(3)23-35-36-25(22(30)31)37(23)12-17/h6-13,20,22H,1-5H3/t20-/m1/s1
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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380694
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H27ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-9,13-15,24H,10-12H2,1-4H3/t24-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380699
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-24-22(29-26(33)19-9-11-36-12-10-19)27(35)34(23(24)18-5-7-20(28)8-6-18)21-13-16(3)25-31-30-17(4)32(25)14-21/h5-8,13-15,19,23H,9-12H2,1-4H3
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380699
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-24-22(29-26(33)19-9-11-36-12-10-19)27(35)34(23(24)18-5-7-20(28)8-6-18)21-13-16(3)25-31-30-17(4)32(25)14-21/h5-8,13-15,19,23H,9-12H2,1-4H3
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380716
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)32-23-21(28-25(32)18-9-11-36-12-10-18)26(35)33(22(23)17-5-7-19(27)8-6-17)20-13-15(3)24-30-29-16(4)34(24)31-20/h5-9,13-14,22H,10-12H2,1-4H3/t22-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380723
PNG
((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Show SMILES CC(C)n1c(C)nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
Show InChI InChI=1S/C22H22ClN7O/c1-11(2)28-13(4)24-18-20(28)19(15-6-8-16(23)9-7-15)29(22(18)31)17-10-12(3)21-26-25-14(5)30(21)27-17/h6-11,19H,1-5H3/t19-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380750
PNG
(6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]triaz...)
Show SMILES COc1ccc(cn1)-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C27H25ClN8O2/c1-14(2)35-24-22(31-25(35)17-8-11-20(38-5)29-13-17)27(37)36(23(24)16-6-9-18(28)10-7-16)19-12-15(3)21-26(30-19)34(4)33-32-21/h6-14,23H,1-5H3
PDB

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n/an/a 11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380770
PNG
(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)33-23-21(29-24(33)17-9-11-36-12-10-17)26(35)34(22(23)16-5-7-18(27)8-6-16)19-13-15(3)20-25(28-19)32(4)31-30-20/h5-9,13-14,22H,10-12H2,1-4H3
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380778
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2n1
Show InChI InChI=1S/C27H23ClF2N8O2/c1-13(2)36-21-19(32-24(36)17-6-5-11-31-26(17)40-4)27(39)37(20(21)15-7-9-16(28)10-8-15)18-12-14(3)23-33-34-25(22(29)30)38(23)35-18/h5-13,20,22H,1-4H3/t20-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380758
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES CC(C)n1c(C)nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1S/C23H21ClF2N6O/c1-11(2)31-13(4)27-17-19(31)18(14-5-7-15(24)8-6-14)32(23(17)33)16-9-12(3)21-28-29-22(20(25)26)30(21)10-16/h5-11,18,20H,1-4H3/t18-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380774
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)33-23-21(29-24(33)17-9-11-36-12-10-17)26(35)34(22(23)16-5-7-18(27)8-6-16)19-13-15(3)20-25(28-19)32(4)31-30-20/h5-9,13-14,22H,10-12H2,1-4H3/t22-/m1/s1
PDB

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n/an/a<11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380774
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)33-23-21(29-24(33)17-9-11-36-12-10-17)26(35)34(22(23)16-5-7-18(27)8-6-16)19-13-15(3)20-25(28-19)32(4)31-30-20/h5-9,13-14,22H,10-12H2,1-4H3/t22-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380778
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2n1
Show InChI InChI=1S/C27H23ClF2N8O2/c1-13(2)36-21-19(32-24(36)17-6-5-11-31-26(17)40-4)27(39)37(20(21)15-7-9-16(28)10-8-15)18-12-14(3)23-33-34-25(22(29)30)38(23)35-18/h5-13,20,22H,1-4H3/t20-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380670
PNG
(6-(4-chlorophenyl)-2-cyclopropyl-5-(3,8-dimethyl-[...)
Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(nc(C3CC3)n2C)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN6O/c1-12-10-17(11-29-13(2)26-27-21(12)29)30-19(14-6-8-16(24)9-7-14)20-18(23(30)31)25-22(28(20)3)15-4-5-15/h6-11,15,19H,4-5H2,1-3H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380694
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H27ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-9,13-15,24H,10-12H2,1-4H3/t24-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380772
PNG
(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Show SMILES Cc1cc(nc2n(C)nnc12)N1C(c2[nH]c(nc2C1=O)C1=CCOCC1)c1ccc(Cl)cc1
Show InChI InChI=1/C23H20ClN7O2/c1-12-11-16(25-22-17(12)28-29-30(22)2)31-20(13-3-5-15(24)6-4-13)18-19(23(31)32)27-21(26-18)14-7-9-33-10-8-14/h3-7,11,20H,8-10H2,1-2H3,(H,26,27)
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380781
PNG
((6R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tri...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1)C1CCOC1
Show InChI InChI=1S/C25H26ClN7O2/c1-13(2)31-22-20(27-24(31)17-9-10-35-12-17)25(34)32(21(22)16-5-7-18(26)8-6-16)19-11-14(3)23-29-28-15(4)33(23)30-19/h5-8,11,13,17,21H,9-10,12H2,1-4H3/t17?,21-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380682
PNG
(US9890166, Example 69 | isobutyl 4-(6-(4-chlorophe...)
Show SMILES CC(C)COC(=O)N1CCC(=CC1)c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C32H36ClN7O3/c1-18(2)17-43-32(42)37-13-11-23(12-14-37)30-34-26-28(39(30)19(3)4)27(22-7-9-24(33)10-8-22)40(31(26)41)25-15-20(5)29-36-35-21(6)38(29)16-25/h7-11,15-16,18-19,27H,12-14,17H2,1-6H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380731
PNG
((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-benzo[d]...)
Show SMILES CC(C)n1c(C)nc2[C@H](N(C(=O)c12)c1cc(C)c2nnn(C)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN6O/c1-12(2)29-14(4)25-20-21(15-6-8-16(24)9-7-15)30(23(31)22(20)29)17-10-13(3)19-18(11-17)28(5)27-26-19/h6-12,21H,1-5H3/t21-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380758
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES CC(C)n1c(C)nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1S/C23H21ClF2N6O/c1-11(2)31-13(4)27-17-19(31)18(14-5-7-15(24)8-6-14)32(23(17)33)16-9-12(3)21-28-29-22(20(25)26)30(21)10-16/h5-11,18,20H,1-4H3/t18-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380723
PNG
((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Show SMILES CC(C)n1c(C)nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
Show InChI InChI=1S/C22H22ClN7O/c1-11(2)28-13(4)24-18-20(28)19(15-6-8-16(23)9-7-15)29(22(18)31)17-10-12(3)21-26-25-14(5)30(21)27-17/h6-11,19H,1-5H3/t19-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380769
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3nnc(C(F)F)n3c2)c(OC)n1
Show InChI InChI=1S/C28H25ClF2N8O3/c1-13(2)38-21-19(33-24(38)18-11-32-28(42-5)34-26(18)41-4)27(40)39(20(21)15-6-8-16(29)9-7-15)17-10-14(3)23-35-36-25(22(30)31)37(23)12-17/h6-13,20,22H,1-5H3/t20-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380776
PNG
((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2[nH]1)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1/C24H19ClN8O2/c1-12-11-16(27-22-17(12)30-31-32(22)2)33-20(13-6-8-14(25)9-7-13)18-19(24(33)34)29-21(28-18)15-5-4-10-26-23(15)35-3/h4-11,20H,1-3H3,(H,28,29)/t20-/s2
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380685
PNG
(N-(tert-butyl)-4-(6-(4-chlorophenyl)-5-(3,8-dimeth...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1=CCN(CC1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H37ClN8O2/c1-18(2)40-27-25(34-29(40)22-12-14-38(15-13-22)31(43)35-32(5,6)7)30(42)41(26(27)21-8-10-23(33)11-9-21)24-16-19(3)28-37-36-20(4)39(28)17-24/h8-12,16-18,26H,13-15H2,1-7H3,(H,35,43)
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380693
PNG
(6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d][1,2...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-8,13-15,18,24H,9-12H2,1-4H3
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380744
PNG
(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)
Show SMILES COc1ncccc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1S/C28H24ClF2N7O2/c1-14(2)37-22-20(33-25(37)19-6-5-11-32-27(19)40-4)28(39)38(21(22)16-7-9-17(29)10-8-16)18-12-15(3)24-34-35-26(23(30)31)36(24)13-18/h5-14,21,23H,1-4H3
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM380617
PNG
(6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-benzo[d][1,2...)
Show SMILES CC(C)n1c(C)nc2C(N(C(=O)c12)c1cc(C)c2nnn(C)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN6O/c1-12(2)29-14(4)25-20-21(15-6-8-16(24)9-7-15)30(23(31)22(20)29)17-10-13(3)19-18(11-17)28(5)27-26-19/h6-12,21H,1-5H3
PDB

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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM380765
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2[nH]1)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1/C25H18ClF2N7O2/c1-12-10-15(11-34-22(12)32-33-23(34)20(27)28)35-19(13-5-7-14(26)8-6-13)17-18(25(35)36)31-21(30-17)16-4-3-9-29-24(16)37-2/h3-11,19-20H,1-2H3,(H,30,31)/t19-/s2
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380695
PNG
((R)-6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d]...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-8,13-15,18,24H,9-12H2,1-4H3/t24-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)

More data for this
Ligand-Target Pair
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