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Patent code US9896435

Compile Data Set for Download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373055
PNG
(US9896435, Example 3)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cccnc2F)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H29F3N6O2/c1-18-26(21-9-6-12-33-27(21)32)36-38(20-7-4-3-5-8-20)28(18)35-29(39)34-25-17-37(13-14-40-2)16-22(25)19-10-11-23(30)24(31)15-19/h3-12,15,22,25H,13-14,16-17H2,1-2H3,(H2,34,35,39)/t22-,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373082
PNG
(US9896435, Example 30)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)S(C)(=O)=O)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C25H29F2N5O4S/c1-16-23(32(18-7-5-4-6-8-18)30-24(16)37(3,34)35)29-25(33)28-22-15-31(11-12-36-2)14-19(22)17-9-10-20(26)21(27)13-17/h4-10,13,19,22H,11-12,14-15H2,1-3H3,(H2,28,29,33)/t19-,22+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373064
PNG
(US9896435, Example 12)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(OC)nc2)[C@@H](C1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H31F2N7O3/c1-18-26(20-14-32-29(41-3)33-15-20)36-38(23-7-5-4-6-8-23)27(18)35-28(39)34-25-17-37(9-10-40-2)16-24(25)19-11-21(30)13-22(31)12-19/h4-8,11-15,24-25H,9-10,16-17H2,1-3H3,(H2,34,35,39)/t24-,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373076
PNG
(US9896435, Example 24)
Show SMILES COCCN1CC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)[C@@H](C1)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C30H32ClFN6O3/c1-19-28(20-9-10-27(39)36(2)16-20)35-38(24-7-5-4-6-8-24)29(19)34-30(40)33-26-18-37(11-12-41-3)17-25(26)21-13-22(31)15-23(32)14-21/h4-10,13-16,25-26H,11-12,17-18H2,1-3H3,(H2,33,34,40)/t25-,26?/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373079
PNG
(US9896435, Example 27)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)[C@@H](C1)c1cccc(F)c1
Show InChI InChI=1S/C30H33FN6O3/c1-20-28(22-12-13-27(38)35(2)17-22)34-37(24-10-5-4-6-11-24)29(20)33-30(39)32-26-19-36(14-15-40-3)18-25(26)21-8-7-9-23(31)16-21/h4-13,16-17,25-26H,14-15,18-19H2,1-3H3,(H2,32,33,39)/t25-,26+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373058
PNG
(US9896435, Example 6)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cncc(OC)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H32F2N6O3/c1-19-28(21-13-23(41-3)16-33-15-21)36-38(22-7-5-4-6-8-22)29(19)35-30(39)34-27-18-37(11-12-40-2)17-24(27)20-9-10-25(31)26(32)14-20/h4-10,13-16,24,27H,11-12,17-18H2,1-3H3,(H2,34,35,39)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373069
PNG
(US9896435, Example 17)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)n2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H31F2N7O3/c1-18-27(24-11-12-26(39)36(2)34-24)35-38(20-7-5-4-6-8-20)28(18)33-29(40)32-25-17-37(13-14-41-3)16-21(25)19-9-10-22(30)23(31)15-19/h4-12,15,21,25H,13-14,16-17H2,1-3H3,(H2,32,33,40)/t21-,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373074
PNG
(US9896435, Example 22)
Show SMILES COCCN1CC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)[C@@H](C1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C30H32ClFN6O3/c1-19-28(21-10-12-27(39)36(2)16-21)35-38(22-7-5-4-6-8-22)29(19)34-30(40)33-26-18-37(13-14-41-3)17-23(26)20-9-11-25(32)24(31)15-20/h4-12,15-16,23,26H,13-14,17-18H2,1-3H3,(H2,33,34,40)/t23-,26?/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373056
PNG
(US9896435, Example 4)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cccnc2C)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H32F2N6O2/c1-19-28(23-10-7-13-33-20(23)2)36-38(22-8-5-4-6-9-22)29(19)35-30(39)34-27-18-37(14-15-40-3)17-24(27)21-11-12-25(31)26(32)16-21/h4-13,16,24,27H,14-15,17-18H2,1-3H3,(H2,34,35,39)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373081
PNG
(US9896435, Example 29)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cc(C)c(=O)n(C)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H34F2N6O3/c1-19-14-22(16-37(3)30(19)40)28-20(2)29(39(36-28)23-8-6-5-7-9-23)35-31(41)34-27-18-38(12-13-42-4)17-24(27)21-10-11-25(32)26(33)15-21/h5-11,14-16,24,27H,12-13,17-18H2,1-4H3,(H2,34,35,41)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373053
PNG
(US9896435, Example 1)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(C)nc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H32F2N6O2/c1-19-9-10-22(16-33-19)28-20(2)29(38(36-28)23-7-5-4-6-8-23)35-30(39)34-27-18-37(13-14-40-3)17-24(27)21-11-12-25(31)26(32)15-21/h4-12,15-16,24,27H,13-14,17-18H2,1-3H3,(H2,34,35,39)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373054
PNG
(US9896435, Example 2)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccnc(C)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H32F2N6O2/c1-19-15-22(11-12-33-19)28-20(2)29(38(36-28)23-7-5-4-6-8-23)35-30(39)34-27-18-37(13-14-40-3)17-24(27)21-9-10-25(31)26(32)16-21/h4-12,15-16,24,27H,13-14,17-18H2,1-3H3,(H2,34,35,39)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373059
PNG
(US9896435, Example 7)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cncc(c2)C#N)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H29F2N7O2/c1-19-28(22-12-20(14-33)15-34-16-22)37-39(23-6-4-3-5-7-23)29(19)36-30(40)35-27-18-38(10-11-41-2)17-24(27)21-8-9-25(31)26(32)13-21/h3-9,12-13,15-16,24,27H,10-11,17-18H2,1-2H3,(H2,35,36,40)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373068
PNG
(US9896435, Example 16)
Show SMILES CCOc1ncc(cn1)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2cc(F)cc(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C30H33F2N7O3/c1-4-42-30-33-15-21(16-34-30)27-19(2)28(39(37-27)24-8-6-5-7-9-24)36-29(40)35-26-18-38(10-11-41-3)17-25(26)20-12-22(31)14-23(32)13-20/h5-9,12-16,25-26H,4,10-11,17-18H2,1-3H3,(H2,35,36,40)/t25-,26+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373070
PNG
(US9896435, Example 18)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)n2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C29H32FN7O3/c1-19-27(24-13-14-26(38)35(2)33-24)34-37(22-7-5-4-6-8-22)28(19)32-29(39)31-25-18-36(15-16-40-3)17-23(25)20-9-11-21(30)12-10-20/h4-14,23,25H,15-18H2,1-3H3,(H2,31,32,39)/t23-,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373077
PNG
(US9896435, Example 25)
Show SMILES COCCN1CC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)[C@@H](C1)c1cccc(Cl)c1
Show InChI InChI=1S/C30H33ClN6O3/c1-20-28(22-12-13-27(38)35(2)17-22)34-37(24-10-5-4-6-11-24)29(20)33-30(39)32-26-19-36(14-15-40-3)18-25(26)21-8-7-9-23(31)16-21/h4-13,16-17,25-26H,14-15,18-19H2,1-3H3,(H2,32,33,39)/t25-,26?/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373078
PNG
(US10323022, Example 604 | US9896435, Example 26)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)[C@@H](C1)c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C30H31F3N6O3/c1-18-28(19-9-10-26(40)37(2)15-19)36-39(21-7-5-4-6-8-21)29(18)35-30(41)34-25-17-38(11-12-42-3)16-22(25)20-13-23(31)27(33)24(32)14-20/h4-10,13-15,22,25H,11-12,16-17H2,1-3H3,(H2,34,35,41)/t22-,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373057
PNG
(US9896435, Example 5)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cncc(C)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H32F2N6O2/c1-19-13-22(16-33-15-19)28-20(2)29(38(36-28)23-7-5-4-6-8-23)35-30(39)34-27-18-37(11-12-40-3)17-24(27)21-9-10-25(31)26(32)14-21/h4-10,13-16,24,27H,11-12,17-18H2,1-3H3,(H2,34,35,39)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373062
PNG
(US9896435, Example 10)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(nc2)C2CC2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H33F2N7O2/c1-19-28(22-15-34-29(35-16-22)20-8-9-20)38-40(23-6-4-3-5-7-23)30(19)37-31(41)36-27-18-39(12-13-42-2)17-24(27)21-10-11-25(32)26(33)14-21/h3-7,10-11,14-16,20,24,27H,8-9,12-13,17-18H2,1-2H3,(H2,36,37,41)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373072
PNG
(US9896435, Example 20)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(NC3CC3)nc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H34F2N8O2/c1-19-28(21-15-34-30(35-16-21)36-22-9-10-22)39-41(23-6-4-3-5-7-23)29(19)38-31(42)37-27-18-40(12-13-43-2)17-24(27)20-8-11-25(32)26(33)14-20/h3-8,11,14-16,22,24,27H,9-10,12-13,17-18H2,1-2H3,(H,34,35,36)(H2,37,38,42)/t24-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373060
PNG
(US9896435, Example 8)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(OC)nc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H32F2N6O3/c1-19-28(21-10-12-27(41-3)33-16-21)36-38(22-7-5-4-6-8-22)29(19)35-30(39)34-26-18-37(13-14-40-2)17-23(26)20-9-11-24(31)25(32)15-20/h4-12,15-16,23,26H,13-14,17-18H2,1-3H3,(H2,34,35,39)/t23-,26+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373066
PNG
(US9896435, Example 14)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(C)nc2)[C@@H](C1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H31F2N7O2/c1-18-27(21-14-32-19(2)33-15-21)36-38(24-7-5-4-6-8-24)28(18)35-29(39)34-26-17-37(9-10-40-3)16-25(26)20-11-22(30)13-23(31)12-20/h4-8,11-15,25-26H,9-10,16-17H2,1-3H3,(H2,34,35,39)/t25-,26+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373073
PNG
(US9896435, Example 21)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(NC3CC3)nc2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C31H35FN8O2/c1-20-28(22-16-33-30(34-17-22)35-24-12-13-24)38-40(25-6-4-3-5-7-25)29(20)37-31(41)36-27-19-39(14-15-42-2)18-26(27)21-8-10-23(32)11-9-21/h3-11,16-17,24,26-27H,12-15,18-19H2,1-2H3,(H,33,34,35)(H2,36,37,41)/t26-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373075
PNG
(US9896435, Example 23)
Show SMILES COCCN1CC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)[C@@H](C1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C30H32ClFN6O3/c1-19-28(21-10-12-27(39)36(2)16-21)35-38(22-7-5-4-6-8-22)29(19)34-30(40)33-26-18-37(13-14-41-3)17-23(26)20-9-11-24(31)25(32)15-20/h4-12,15-16,23,26H,13-14,17-18H2,1-3H3,(H2,33,34,40)/t23-,26?/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373061
PNG
(US9896435, Example 9)
Show SMILES CCOc1ncc(cn1)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C30H33F2N7O3/c1-4-42-30-33-15-21(16-34-30)27-19(2)28(39(37-27)22-8-6-5-7-9-22)36-29(40)35-26-18-38(12-13-41-3)17-23(26)20-10-11-24(31)25(32)14-20/h5-11,14-16,23,26H,4,12-13,17-18H2,1-3H3,(H2,35,36,40)/t23-,26+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373065
PNG
(US9896435, Example 13)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(C)nc2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C29H32FN7O2/c1-19-27(22-15-31-20(2)32-16-22)35-37(24-7-5-4-6-8-24)28(19)34-29(38)33-26-18-36(13-14-39-3)17-25(26)21-9-11-23(30)12-10-21/h4-12,15-16,25-26H,13-14,17-18H2,1-3H3,(H2,33,34,38)/t25-,26+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373071
PNG
(US9896435, Example 19)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)n2)[C@@H](C1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H31F2N7O3/c1-18-27(24-9-10-26(39)36(2)34-24)35-38(22-7-5-4-6-8-22)28(18)33-29(40)32-25-17-37(11-12-41-3)16-23(25)19-13-20(30)15-21(31)14-19/h4-10,13-15,23,25H,11-12,16-17H2,1-3H3,(H2,32,33,40)/t23-,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373083
PNG
(US9896435, Example 31)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)C(C)=O)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C26H29F2N5O3/c1-16-24(17(2)34)31-33(19-7-5-4-6-8-19)25(16)30-26(35)29-23-15-32(11-12-36-3)14-20(23)18-9-10-21(27)22(28)13-18/h4-10,13,20,23H,11-12,14-15H2,1-3H3,(H2,29,30,35)/t20-,23+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373067
PNG
(US9896435, Example 15)
Show SMILES CCOc1ncc(cn1)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)cc2)c1C)-c1ccccc1
Show InChI InChI=1S/C30H34FN7O3/c1-4-41-30-32-16-22(17-33-30)27-20(2)28(38(36-27)24-8-6-5-7-9-24)35-29(39)34-26-19-37(14-15-40-3)18-25(26)21-10-12-23(31)13-11-21/h5-13,16-17,25-26H,4,14-15,18-19H2,1-3H3,(H2,34,35,39)/t25-,26+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373080
PNG
(US9896435, Example 28)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(=O)n(C)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H31F2N7O3/c1-18-26(20-14-32-29(40)36(2)15-20)35-38(21-7-5-4-6-8-21)27(18)34-28(39)33-25-17-37(11-12-41-3)16-22(25)19-9-10-23(30)24(31)13-19/h4-10,13-15,22,25H,11-12,16-17H2,1-3H3,(H2,33,34,39)/t22-,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373063
PNG
(US9896435, Example 11)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(nc2)C2CC2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C31H34FN7O2/c1-20-28(23-16-33-29(34-17-23)22-8-9-22)37-39(25-6-4-3-5-7-25)30(20)36-31(40)35-27-19-38(14-15-41-2)18-26(27)21-10-12-24(32)13-11-21/h3-7,10-13,16-17,22,26-27H,8-9,14-15,18-19H2,1-2H3,(H2,35,36,40)/t26-,27+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...

US Patent US9896435 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9F4B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%