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Patent code US9896436

Compile Data Set for Download or QSAR

Found 329 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276041
PNG
(2-[5-(4-fluorophenyl)-1-methylimidazol-4-yl]-4-(1H...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H13FN6/c1-24-10-20-16(17(24)11-2-4-13(18)5-3-11)14-8-12(6-7-19-14)15-9-21-23-22-15/h2-10H,1H3,(H,21,22,23)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276050
PNG
(2-[1-(3,4-dihydro-2H-chromen-4-ylmethyl)imidazol-4...)
Show SMILES C(C1CCOc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1/C20H18N6O/c1-2-4-20-16(3-1)15(6-8-27-20)11-26-12-19(22-13-26)17-9-14(5-7-21-17)18-10-23-25-24-18/h1-5,7,9-10,12-13,15H,6,8,11H2,(H,23,24,25)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276053
PNG
(4-[2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)i...)
Show SMILES N#Cc1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
Show InChI InChI=1/C22H19N7/c23-11-20-22(27-28-26-20)16-8-9-24-19(10-16)21-13-29(14-25-21)12-17-6-3-5-15-4-1-2-7-18(15)17/h1-2,4,7-10,13-14,17H,3,5-6,12H2,(H,26,27,28)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276056
PNG
(2-[1-[2-(2-phenoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C24H20N6O/c1-2-7-20(8-3-1)31-24-9-5-4-6-18(24)11-13-30-16-23(26-17-30)21-14-19(10-12-25-21)22-15-27-29-28-22/h1-10,12,14-17H,11,13H2,(H,27,28,29)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276058
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Fc1[nH]nnc1-c1ccnc(c1)-c1cn(Cc2cccc(Cl)c2Cl)cn1
Show InChI InChI=1S/C17H11Cl2FN6/c18-12-3-1-2-11(15(12)19)7-26-8-14(22-9-26)13-6-10(4-5-21-13)16-17(20)24-25-23-16/h1-6,8-9H,7H2,(H,23,24,25)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276061
PNG
(2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]-4-(1H-...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1cccc2ccccc12
Show InChI InChI=1S/C22H18N6/c1-2-7-19-16(4-1)5-3-6-17(19)9-11-28-14-22(24-15-28)20-12-18(8-10-23-20)21-13-25-27-26-21/h1-8,10,12-15H,9,11H2,(H,25,26,27)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276073
PNG
(4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...)
Show SMILES Fc1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
Show InChI InChI=1S/C22H17FN6/c23-22-21(26-28-27-22)17-8-10-24-19(12-17)20-13-29(14-25-20)11-9-16-6-3-5-15-4-1-2-7-18(15)16/h1-8,10,12-14H,9,11H2,(H,26,27,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276083
PNG
(1-[(2-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Show SMILES Clc1ccccc1Cn1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C15H11ClN6/c16-11-4-2-1-3-10(11)7-22-8-15(18-9-22)12-5-13-14(6-17-12)20-21-19-13/h1-6,8-9H,7H2,(H,19,20,21)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (Human))
BDBM276083
PNG
(1-[(2-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Show SMILES Clc1ccccc1Cn1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C15H11ClN6/c16-11-4-2-1-3-10(11)7-22-8-15(18-9-22)12-5-13-14(6-17-12)20-21-19-13/h1-6,8-9H,7H2,(H,19,20,21)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276086
PNG
(1-[(3,4-dichlorophenyl)methyl]-4-{1H-[1,2,3]triazo...)
Show SMILES Clc1ccc(Cn2cnc(c2)-c2cc3[nH]nnc3cn2)cc1Cl
Show InChI InChI=1S/C15H10Cl2N6/c16-10-2-1-9(3-11(10)17)6-23-7-15(19-8-23)12-4-13-14(5-18-12)21-22-20-13/h1-5,7-8H,6H2,(H,20,21,22)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (Human))
BDBM276087
PNG
(1-(4-chlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyr...)
Show SMILES Clc1ccc(cc1)-n1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C14H9ClN6/c15-9-1-3-10(4-2-9)21-7-14(17-8-21)11-5-12-13(6-16-11)19-20-18-12/h1-8H,(H,18,19,20)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319639
PNG
(2-{1-[(1,2,3,4-tetrahydronaphthalen-1-yl)methyl]- ...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
Show InChI InChI=1/C22H19F3N6/c23-22(24,25)21-20(28-30-29-21)15-8-9-26-18(10-15)19-12-31(13-27-19)11-16-6-3-5-14-4-1-2-7-17(14)16/h1-2,4,7-10,12-13,16H,3,5-6,11H2,(H,28,29,30)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319651
PNG
(2-{1-[(4-fluoro-2-methylphenyl)methyl]-1H- imidazo...)
Show SMILES Cc1cc(F)ccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C19H14F4N6/c1-11-6-14(20)3-2-13(11)8-29-9-16(25-10-29)15-7-12(4-5-24-15)17-18(19(21,22)23)27-28-26-17/h2-7,9-10H,8H2,1H3,(H,26,27,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319655
PNG
(2-[1-(1-phenylpropyl)-1H-imidazol-4-yl]-4-[5- (tri...)
Show SMILES CCC(c1ccccc1)n1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1/C20H17F3N6/c1-2-17(13-6-4-3-5-7-13)29-11-16(25-12-29)15-10-14(8-9-24-15)18-19(20(21,22)23)27-28-26-18/h3-12,17H,2H2,1H3,(H,26,27,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM373163
PNG
(2-{1-[2-(4-fluorophenyl)ethyl]-1H-imidazol- 4-yl}-...)
Show SMILES Fc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1
Show InChI InChI=1S/C19H14F4N6/c20-14-3-1-12(2-4-14)6-8-29-10-16(25-11-29)15-9-13(5-7-24-15)17-18(19(21,22)23)27-28-26-17/h1-5,7,9-11H,6,8H2,(H,26,27,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319669
PNG
(2-{1-[2-(2,5-difluorophenyl)ethyl]-1H-imidazol-4- ...)
Show SMILES Fc1ccc(F)c(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c1
Show InChI InChI=1S/C19H13F5N6/c20-13-1-2-14(21)11(7-13)4-6-30-9-16(26-10-30)15-8-12(3-5-25-15)17-18(19(22,23)24)28-29-27-17/h1-3,5,7-10H,4,6H2,(H,27,28,29)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319672
PNG
(2-{1-[2-(4-methylphenyl)ethyl]-1H-imidazol-4-yl}- ...)
Show SMILES Cc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1
Show InChI InChI=1S/C20H17F3N6/c1-13-2-4-14(5-3-13)7-9-29-11-17(25-12-29)16-10-15(6-8-24-16)18-19(20(21,22)23)27-28-26-18/h2-6,8,10-12H,7,9H2,1H3,(H,26,27,28)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319674
PNG
(2-{1-[2-(4-methoxyphenyl)ethyl]-1H-imidazol-4-yl}-...)
Show SMILES COc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1
Show InChI InChI=1S/C20H17F3N6O/c1-30-15-4-2-13(3-5-15)7-9-29-11-17(25-12-29)16-10-14(6-8-24-16)18-19(20(21,22)23)27-28-26-18/h2-6,8,10-12H,7,9H2,1H3,(H,26,27,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319682
PNG
(2-{1-[(7-fluoro-1,2,3,4-tetrahydronaphthalen-1- yl...)
Show SMILES Fc1ccc2CCCC(Cn3cnc(c3)-c3cc(ccn3)-c3nn[nH]c3C(F)(F)F)c2c1
Show InChI InChI=1/C22H18F4N6/c23-16-5-4-13-2-1-3-15(17(13)9-16)10-32-11-19(28-12-32)18-8-14(6-7-27-18)20-21(22(24,25)26)30-31-29-20/h4-9,11-12,15H,1-3,10H2,(H,29,30,31)
PDB

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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (Human))
BDBM276059
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1Cl
Show InChI InChI=1S/C17H12Cl2N6/c18-13-3-1-2-12(17(13)19)8-25-9-16(21-10-25)14-6-11(4-5-20-14)15-7-22-24-23-15/h1-7,9-10H,8H2,(H,22,23,24)
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276068
PNG
(2-[1-[(2-fluoro-3-methoxyphenyl)methyl]imidazol-4-...)
Show SMILES COc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F
Show InChI InChI=1S/C18H15FN6O/c1-26-17-4-2-3-13(18(17)19)9-25-10-16(21-11-25)14-7-12(5-6-20-14)15-8-22-24-23-15/h2-8,10-11H,9H2,1H3,(H,22,23,24)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276084
PNG
(1-[(3-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc3[nH]nnc3cn2)c1
Show InChI InChI=1S/C15H11ClN6/c16-11-3-1-2-10(4-11)7-22-8-15(18-9-22)12-5-13-14(6-17-12)20-21-19-13/h1-6,8-9H,7H2,(H,19,20,21)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319659
PNG
(2-{1-[2-(3-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES Fc1cccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c1
Show InChI InChI=1S/C19H14F4N6/c20-14-3-1-2-12(8-14)5-7-29-10-16(25-11-29)15-9-13(4-6-24-15)17-18(19(21,22)23)27-28-26-17/h1-4,6,8-11H,5,7H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319667
PNG
(2-{1-[2-(2,4-difluorophenyl)ethyl]-1H-imidazol-4- ...)
Show SMILES Fc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H13F5N6/c20-13-2-1-11(14(21)8-13)4-6-30-9-16(26-10-30)15-7-12(3-5-25-15)17-18(19(22,23)24)28-29-27-17/h1-3,5,7-10H,4,6H2,(H,27,28,29)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319669
PNG
(2-{1-[2-(2,5-difluorophenyl)ethyl]-1H-imidazol-4- ...)
Show SMILES Fc1ccc(F)c(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c1
Show InChI InChI=1S/C19H13F5N6/c20-13-1-2-14(21)11(7-13)4-6-30-9-16(26-10-30)15-8-12(3-5-25-15)17-18(19(22,23)24)28-29-27-17/h1-3,5,7-10H,4,6H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319678
PNG
(2-[5-(4-fluorophenyl)-1-methyl-1H-imidazol-4-yl]-4...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C18H12F4N6/c1-28-9-24-15(16(28)10-2-4-12(19)5-3-10)13-8-11(6-7-23-13)14-17(18(20,21)22)26-27-25-14/h2-9H,1H3,(H,25,26,27)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319679
PNG
(2-{1-[(3,4-dihydro-2H-1-benzopyran-4-yl)methyl]- 1...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCOc3ccccc23)cn1
Show InChI InChI=1/C21H17F3N6O/c22-21(23,24)20-19(27-29-28-20)13-5-7-25-16(9-13)17-11-30(12-26-17)10-14-6-8-31-18-4-2-1-3-15(14)18/h1-5,7,9,11-12,14H,6,8,10H2,(H,27,28,29)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319681
PNG
(2-{1-[(6-fluoro-1,2,3,4-tetrahydronaphthalen-1- yl...)
Show SMILES Fc1ccc2C(Cn3cnc(c3)-c3cc(ccn3)-c3nn[nH]c3C(F)(F)F)CCCc2c1
Show InChI InChI=1/C22H18F4N6/c23-16-4-5-17-13(8-16)2-1-3-15(17)10-32-11-19(28-12-32)18-9-14(6-7-27-18)20-21(22(24,25)26)30-31-29-20/h4-9,11-12,15H,1-3,10H2,(H,29,30,31)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276044
PNG
(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276048
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(2,2,2-trifluoroeth...)
Show SMILES FC(F)(F)COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)12-30-19-4-2-1-3-14(19)6-8-29-11-18(25-13-29)16-9-15(5-7-24-16)17-10-26-28-27-17/h1-5,7,9-11,13H,6,8,12H2,(H,26,27,28)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276049
PNG
(2-[1-[2-[2-(cyclopropylmethoxy)phenyl]ethyl]imidaz...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1OCC1CC1
Show InChI InChI=1S/C22H22N6O/c1-2-4-22(29-14-16-5-6-16)17(3-1)8-10-28-13-21(24-15-28)19-11-18(7-9-23-19)20-12-25-27-26-20/h1-4,7,9,11-13,15-16H,5-6,8,10,14H2,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276052
PNG
(4-[2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C#N)c1Cl
Show InChI InChI=1S/C18H11Cl2N7/c19-13-3-1-2-12(17(13)20)8-27-9-16(23-10-27)14-6-11(4-5-22-14)18-15(7-21)24-26-25-18/h1-6,9-10H,8H2,(H,24,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276055
PNG
(2-[1-[2-(2-phenylmethoxyphenyl)ethyl]imidazol-4-yl...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C25H22N6O/c1-2-6-19(7-3-1)17-32-25-9-5-4-8-20(25)11-13-31-16-24(27-18-31)22-14-21(10-12-26-22)23-15-28-30-29-23/h1-10,12,14-16,18H,11,13,17H2,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276067
PNG
(2-[1-[(3-chloro-2-fluorophenyl)methyl]imidazol-4-y...)
Show SMILES Fc1c(Cl)cccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H12ClFN6/c18-13-3-1-2-12(17(13)19)8-25-9-16(21-10-25)14-6-11(4-5-20-14)15-7-22-24-23-15/h1-7,9-10H,8H2,(H,22,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276078
PNG
(4-(5-chloro-1H-triazol-4-yl)-2-[5-[2-(cyclopropylm...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1Cl
Show InChI InChI=1S/C21H18ClFN6O/c1-29-11-25-19(16-8-13(6-7-24-16)18-21(22)27-28-26-18)20(29)15-5-4-14(23)9-17(15)30-10-12-2-3-12/h4-9,11-12H,2-3,10H2,1H3,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276093
PNG
(2-(5-bromo-1-(2-chlorobenzyl)-1H-imidazol-4-yl)-4-...)
Show SMILES Clc1ccccc1Cn1cnc(c1Br)-c1cc(ccn1)-c1cn[nH]n1
Show InChI InChI=1S/C17H12BrClN6/c18-17-16(14-7-11(5-6-20-14)15-8-22-24-23-15)21-10-25(17)9-12-3-1-2-4-13(12)19/h1-8,10H,9H2,(H,22,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319640
PNG
(2-{1-[2-(2-ethoxyphenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C21H19F3N6O/c1-2-31-18-6-4-3-5-14(18)8-10-30-12-17(26-13-30)16-11-15(7-9-25-16)19-20(21(22,23)24)28-29-27-19/h3-7,9,11-13H,2,8,10H2,1H3,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319646
PNG
(2-{1-[(4-methylphenyl)methyl]-1H-imidazol-4-yl}-4-...)
Show SMILES Cc1ccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1
Show InChI InChI=1S/C19H15F3N6/c1-12-2-4-13(5-3-12)9-28-10-16(24-11-28)15-8-14(6-7-23-15)17-18(19(20,21)22)26-27-25-17/h2-8,10-11H,9H2,1H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319666
PNG
(2-[1-(6-fluoro-2,3-dihydro-1H-inden-1-yl)-1H- imid...)
Show SMILES Fc1ccc2CCC(c2c1)n1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1/C20H14F4N6/c21-13-3-1-11-2-4-17(14(11)8-13)30-9-16(26-10-30)15-7-12(5-6-25-15)18-19(20(22,23)24)28-29-27-18/h1,3,5-10,17H,2,4H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319667
PNG
(2-{1-[2-(2,4-difluorophenyl)ethyl]-1H-imidazol-4- ...)
Show SMILES Fc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H13F5N6/c20-13-2-1-11(14(21)8-13)4-6-30-9-16(26-10-30)15-7-12(3-5-25-15)17-18(19(22,23)24)28-29-27-17/h1-3,5,7-10H,4,6H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM319679
PNG
(2-{1-[(3,4-dihydro-2H-1-benzopyran-4-yl)methyl]- 1...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCOc3ccccc23)cn1
Show InChI InChI=1/C21H17F3N6O/c22-21(23,24)20-19(27-29-28-20)13-5-7-25-16(9-13)17-11-30(12-26-17)10-14-6-8-31-18-4-2-1-3-15(14)18/h1-5,7,9,11-12,14H,6,8,10H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276042
PNG
(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C21H19FN6O/c1-28-12-24-20(17-8-14(6-7-23-17)18-10-25-27-26-18)21(28)16-5-4-15(22)9-19(16)29-11-13-2-3-13/h4-10,12-13H,2-3,11H2,1H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276043
PNG
(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Show SMILES CC(c1ccccc1)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1/C18H16N6/c1-13(14-5-3-2-4-6-14)24-11-18(20-12-24)16-9-15(7-8-19-16)17-10-21-23-22-17/h2-13H,1H3,(H,21,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276046
PNG
(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Show SMILES C(C1CCCc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1/C21H20N6/c1-2-7-18-15(4-1)5-3-6-17(18)12-27-13-21(23-14-27)19-10-16(8-9-22-19)20-11-24-26-25-20/h1-2,4,7-11,13-14,17H,3,5-6,12H2,(H,24,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (Human))
BDBM276047
PNG
(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H20N6O/c1-2-27-20-6-4-3-5-15(20)8-10-26-13-19(22-14-26)17-11-16(7-9-21-17)18-12-23-25-24-18/h3-7,9,11-14H,2,8,10H2,1H3,(H,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (Human))
BDBM276060
PNG
(2-[1-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]i...)
Show SMILES FC(F)(F)c1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1Cl
Show InChI InChI=1S/C18H12ClF3N6/c19-17-12(2-1-3-13(17)18(20,21)22)8-28-9-16(24-10-28)14-6-11(4-5-23-14)15-7-25-27-26-15/h1-7,9-10H,8H2,(H,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276066
PNG
(2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...)
Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F
Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM276082
PNG
(1-benzyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}...)
Show SMILES C(c1ccccc1)n1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C15H12N6/c1-2-4-11(5-3-1)8-21-9-15(17-10-21)12-6-13-14(7-16-12)19-20-18-13/h1-7,9-10H,8H2,(H,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (Human))
BDBM276082
PNG
(1-benzyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}...)
Show SMILES C(c1ccccc1)n1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C15H12N6/c1-2-4-11(5-3-1)8-21-9-15(17-10-21)12-6-13-14(7-16-12)19-20-18-13/h1-7,9-10H,8H2,(H,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (Human))
BDBM276088
PNG
(1-(2-chlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyr...)
Show SMILES Clc1ccccc1-n1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C14H9ClN6/c15-9-3-1-2-4-14(9)21-7-13(17-8-21)10-5-11-12(6-16-10)19-20-18-11/h1-8H,(H,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...


US Patent US9896436 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%