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Patent code US9896458

Compile Data Set for Download or QSAR

Found 251 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356230
PNG
(US9815850, Compound 2 | US9815850, Compound 2A | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356241
PNG
(US9815850, Compound 9 | US9896458, No. 9)
Show SMILES CN1c2ccccc2C2(CC2)C[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1/C24H23N3O3/c1-27-21-10-6-5-9-18(21)24(11-12-24)15-20(23(27)29)25-22(28)19-14-17(30-26-19)13-16-7-3-2-4-8-16/h2-10,14,20H,11-13,15H2,1H3,(H,25,28)/t20-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373524
PNG
(US9896458, No. 12)
Show SMILES CN1c2ccccc2[C@@H](F)CC(NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1/C21H20FN5O2/c1-27-17-10-6-5-9-14(17)15(22)12-16(21(27)29)23-20(28)19-24-18(25-26-19)11-13-7-3-2-4-8-13/h2-10,15-16H,11-12H2,1H3,(H,23,28)(H,24,25,26)/t15-,16?/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356282
PNG
(US9815850, Compound 54A | US9815850, Compound 54B ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O
Show InChI InChI=1/C21H20N6O3/c1-27-19-16(7-4-10-22-19)30-11-15(21(27)29)23-20(28)18-24-17(25-26-18)14-9-8-12-5-2-3-6-13(12)14/h2-7,10,14-15H,8-9,11H2,1H3,(H,23,28)(H,24,25,26)/t14?,15-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356301
PNG
(US9815850, Compound 69A | US9896458, No. 69A)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2cnnc12)c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1/C21H19N7O/c29-21(19-24-18(25-26-19)12-14-6-2-1-3-7-14)23-16-11-10-15-8-4-5-9-17(15)28-13-22-27-20(16)28/h1-9,13,16H,10-12H2,(H,23,29)(H,24,25,26)/t16-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356308
PNG
(US9815850, Compound 73 | US9896458, No. 73)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc([nH]n2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1/C22H21N5O3/c1-27-19-17(8-5-11-23-19)30-13-16(21(27)29)24-20(28)15-12-18(26-25-15)22(9-10-22)14-6-3-2-4-7-14/h2-8,11-12,16H,9-10,13H2,1H3,(H,24,28)(H,25,26)/t16-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356310
PNG
(US9815850, Compound 75A | US9896458, No. 75A)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1/C21H20N6O2/c1-27-19-13(8-5-9-22-19)14-11-15(14)17(21(27)29)24-20(28)18-23-16(25-26-18)10-12-6-3-2-4-7-12/h2-9,14-15,17H,10-11H2,1H3,(H,24,28)(H,23,25,26)/t14-,15-,17-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356318
PNG
(US9815850, Compound 81A | US9896458, No. 81A)
Show SMILES CN1c2ncccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1/C22H20N4O3/c1-26-20-15(8-5-9-23-20)16-12-17(16)19(22(26)28)24-21(27)18-11-14(29-25-18)10-13-6-3-2-4-7-13/h2-9,11,16-17,19H,10,12H2,1H3,(H,24,27)/t16-,17-,19-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356357
PNG
(US9815850, Compound 108 | US9896458, No. 108)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1/C20H19N5O3/c1-25-18-16(8-5-9-21-18)28-12-15(20(25)27)24-19(26)14-11-22-17(23-14)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,22,23)(H,24,26)/t15-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373630
PNG
(US9896458, No. 114A)
Show SMILES CN1c2cnn(C)c2CC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1/C20H21FN6O2/c1-25-17-10-22-26(2)16(17)9-8-15(20(25)29)23-19(28)18-14(21)12-27(24-18)11-13-6-4-3-5-7-13/h3-7,10,12,15H,8-9,11H2,1-2H3,(H,23,28)/t15-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356381
PNG
(US9815850, Compound 124 | US9896458, No. 124)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncc(Cc2ccccc2)s1
Show InChI InChI=1/C21H20N4O3S/c1-13-17(21(27)25(2)18-16(28-13)9-6-10-22-18)24-19(26)20-23-12-15(29-20)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,26)/t13-,17+/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356384
PNG
(US9815850, Compound 126 | US9896458, No. 126)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nc(F)c(Cc3ccccc3)s2)C1=O
Show InChI InChI=1/C20H17FN4O3S/c1-25-17-14(8-5-9-22-17)28-11-13(20(25)27)23-18(26)19-24-16(21)15(29-19)10-12-6-3-2-4-7-12/h2-9,13H,10-11H2,1H3,(H,23,26)/t13-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356394
PNG
(US9815850, Compound 134 | US9815850, Compound 174 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1/C20H19N5O4/c1-12-16(20(27)25(2)17-14(28-12)9-6-10-21-17)22-18(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356405
PNG
(US9815850, Compound 144 | US9896458, No. 144)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cccc(c3)C#N)cc2F)C1=O
Show InChI InChI=1/C21H17FN6O3/c1-27-19-17(6-3-7-24-19)31-12-16(21(27)30)25-20(29)18-15(22)11-28(26-18)10-14-5-2-4-13(8-14)9-23/h2-8,11,16H,10,12H2,1H3,(H,25,29)/t16-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356413
PNG
(US9815850, Compound 150 | US9896458, No. 150)
Show SMILES C[C@H]1Oc2cc(cnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)[nH]1)C#N
Show InChI InChI=1/C21H19N7O3/c1-12-17(21(30)28(2)19-15(31-12)8-14(10-22)11-23-19)25-20(29)18-24-16(26-27-18)9-13-6-4-3-5-7-13/h3-8,11-12,17H,9H2,1-2H3,(H,25,29)(H,24,26,27)/t12-,17+/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356425
PNG
(US9815850, Compound 158 | US9896458, No. 158)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(C#N)n(Cc3ccccc3)n2)C1=O
Show InChI InChI=1/C21H18N6O3/c1-26-19-18(8-5-9-23-19)30-13-17(21(26)29)24-20(28)16-10-15(11-22)27(25-16)12-14-6-3-2-4-7-14/h2-10,17H,12-13H2,1H3,(H,24,28)/t17-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356429
PNG
(US9815850, Compound 161 | US9896458, No. 161)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3cccc(c3)C#N)[nH]2)C1=O
Show InChI InChI=1/C20H17N7O3/c1-27-18-15(6-3-7-22-18)30-11-14(20(27)29)23-19(28)17-24-16(25-26-17)9-12-4-2-5-13(8-12)10-21/h2-8,14H,9,11H2,1H3,(H,23,28)(H,24,25,26)/t14-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356434
PNG
(US9815850, Compound 166 | US9896458, No. 166)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(F)n(Cc3ccc(F)cc3)n2)C1=O
Show InChI InChI=1/C20H17F2N5O3/c1-26-18-16(3-2-8-23-18)30-11-15(20(26)29)24-19(28)14-9-17(22)27(25-14)10-12-4-6-13(21)7-5-12/h2-9,15H,10-11H2,1H3,(H,24,28)/t15-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356460
PNG
(US9815850, Compound 184 | US9896458, No. 184)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cnn(C)c3)cc2F)C1=O
Show InChI InChI=1/C18H18FN7O3/c1-24-7-11(6-21-24)8-26-9-12(19)15(23-26)17(27)22-13-10-29-14-4-3-5-20-16(14)25(2)18(13)28/h3-7,9,13H,8,10H2,1-2H3,(H,22,27)/t13-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356477
PNG
(US9815850, Compound 209 | US9896458, No. 209)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cocn3)cc2F)C1=O
Show InChI InChI=1/C17H15FN6O4/c1-23-15-13(3-2-4-19-15)28-8-12(17(23)26)21-16(25)14-11(18)6-24(22-14)5-10-7-27-9-20-10/h2-4,6-7,9,12H,5,8H2,1H3,(H,21,25)/t12-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356480
PNG
(US9815850, Compound 215 | US9896458, No. 215)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2noc(Cc3ccccc3)n2)C1=O
Show InChI InChI=1/C19H17N5O4/c1-24-17-14(8-5-9-20-17)27-11-13(19(24)26)21-18(25)16-22-15(28-23-16)10-12-6-3-2-4-7-12/h2-9,13H,10-11H2,1H3,(H,21,25)/t13-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356492
PNG
(US9815850, Compound 227 | US9896458, No. 227)
Show SMILES CN1c2nccnc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2ncc(o2)C(F)(F)c2ccccc2)C1=O
Show InChI InChI=1/C21H17F2N5O3/c1-28-17-15(24-7-8-25-17)12-9-13(12)16(20(28)30)27-18(29)19-26-10-14(31-19)21(22,23)11-5-3-2-4-6-11/h2-8,10,12-13,16H,9H2,1H3,(H,27,29)/t12-,13+,16+/s2
PDB

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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356285
PNG
(US9815850, Compound 56 | US9896458, No. 56)
Show SMILES CN1c2cccc(C#N)c2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1/C21H18N6O3/c1-27-16-9-5-8-14(11-22)18(16)30-12-15(21(27)29)23-20(28)19-24-17(25-26-19)10-13-6-3-2-4-7-13/h2-9,15H,10,12H2,1H3,(H,23,28)(H,24,25,26)/t15-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356286
PNG
(US9815850, Compound 57 | US9896458, No. 57)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2NC1=O
Show InChI InChI=1/C19H16FN5O3/c20-13-10-25(9-12-5-2-1-3-6-12)24-16(13)19(27)22-14-11-28-15-7-4-8-21-17(15)23-18(14)26/h1-8,10,14H,9,11H2,(H,22,27)(H,21,23,26)/t14-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356307
PNG
(US9815850, Compound 72 | US9896458, No. 72)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc([nH]n2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1/C23H22N4O3/c1-27-18-9-5-6-10-19(18)30-14-17(22(27)29)24-21(28)16-13-20(26-25-16)23(11-12-23)15-7-3-2-4-8-15/h2-10,13,17H,11-12,14H2,1H3,(H,24,28)(H,25,26)/t17-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356312
PNG
(US9815850, Compound 175 | US9815850, Compound 76 |...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1/C20H18FN5O3/c1-25-18-16(8-5-9-22-18)29-12-15(20(25)28)23-19(27)17-14(21)11-26(24-17)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,27)/t15-/s2
PDB

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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356315
PNG
(US9815850, Compound 79 | US9896458, No. 79)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nc3cccc(-c4ccccc4F)c3s2)C1=O
Show InChI InChI=1/C24H18FN3O3S/c1-28-19-11-4-5-12-20(19)31-13-18(24(28)30)26-22(29)23-27-17-10-6-8-15(21(17)32-23)14-7-2-3-9-16(14)25/h2-12,18H,13H2,1H3,(H,26,29)/t18-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356326
PNG
(US9815850, Compound 86 | US9896458, No. 86)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)s2)C1=O
Show InChI InChI=1/C20H18N4O3S/c1-24-17-16(8-5-9-21-17)27-12-15(20(24)26)23-18(25)19-22-11-14(28-19)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,25)/t15-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356340
PNG
(US9815850, Compound 98B | US9896458, No. 98B)
Show SMILES O=C(N[C@H]1CC2(CC2)c2cccnc2NC1=O)c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1/C21H20N6O2/c28-19-15(12-21(8-9-21)14-7-4-10-22-17(14)25-19)23-20(29)18-24-16(26-27-18)11-13-5-2-1-3-6-13/h1-7,10,15H,8-9,11-12H2,(H,23,29)(H,22,25,28)(H,24,26,27)/t15-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356349
PNG
(US9815850, Compound 103B | US9896458, No. 103B)
Show SMILES Fc1cc(F)c2NC(=O)[C@H](CC3(CC3)c2c1)NC(=O)c1nnc(Cc2ccccc2)[nH]1
Show InChI InChI=1/C22H19F2N5O2/c23-13-9-14-18(15(24)10-13)27-20(30)16(11-22(14)6-7-22)25-21(31)19-26-17(28-29-19)8-12-4-2-1-3-5-12/h1-5,9-10,16H,6-8,11H2,(H,25,31)(H,27,30)(H,26,28,29)/t16-/s2
PDB

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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373628
PNG
(US9896458, No. 112)
Show SMILES C[C@H]1Cc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cc(Cc2ccccc2)on1
Show InChI InChI=1/C22H22N4O3/c1-14-11-16-9-6-10-23-20(16)26(2)22(28)19(14)24-21(27)18-13-17(29-25-18)12-15-7-4-3-5-8-15/h3-10,13-14,19H,11-12H2,1-2H3,(H,24,27)/t14-,19-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373629
PNG
(US9896458, No. 113)
Show SMILES CN1c2ccncc2OC[C@H](NC(=O)c2nnc([nH]2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1/C21H20N6O3/c1-27-15-7-10-22-11-16(15)30-12-14(19(27)29)23-18(28)17-24-20(26-25-17)21(8-9-21)13-5-3-2-4-6-13/h2-7,10-11,14H,8-9,12H2,1H3,(H,23,28)(H,24,25,26)/t14-/s2
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n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356378
PNG
(US9815850, Compound 121B | US9896458, No. 121B)
Show SMILES CN1c2ncccc2CC[C@H](NC(=O)c2cc(Oc3ccc(F)cc3F)ccn2)C1=O
Show InChI InChI=1/C22H18F2N4O3/c1-28-20-13(3-2-9-26-20)4-6-17(22(28)30)27-21(29)18-12-15(8-10-25-18)31-19-7-5-14(23)11-16(19)24/h2-3,5,7-12,17H,4,6H2,1H3,(H,27,29)/t17-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373653
PNG
(US9896458, No. 130)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)C2=N[N](Cc3cc(F)cc(c3)C#N)=C=C2F)C1=O
Show InChI InChI=1/C21H15F2N6O3/c1-28-19-17(3-2-4-25-19)32-11-16(21(28)31)26-20(30)18-15(23)10-29(27-18)9-13-5-12(8-24)6-14(22)7-13/h2-7,16H,9,11H2,1H3,(H,26,30)/t16-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356393
PNG
(US9815850, Compound 133 | US9896458, No. 133)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3F)cc2F)C1=O
Show InChI InChI=1/C20H17F2N5O3/c1-26-18-16(7-4-8-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-5-2-3-6-13(12)21/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356403
PNG
(US9815850, Compound 142 | US9896458, No. 142)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1/C20H18N4O4/c1-24-18-17(8-5-9-21-18)27-12-16(20(24)26)22-19(25)15-11-14(28-23-15)10-13-6-3-2-4-7-13/h2-9,11,16H,10,12H2,1H3,(H,22,25)/t16-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356419
PNG
(US9815850, Compound 154B | US9896458, No. 154B)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2-n2ccnc12
Show InChI InChI=1/C21H17FN6O2/c22-15-12-27(11-14-5-2-1-3-6-14)26-18(15)21(29)25-16-13-30-17-7-4-8-23-20(17)28-10-9-24-19(16)28/h1-10,12,16H,11,13H2,(H,25,29)/t16-/s2
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356420
PNG
(US9815850, Compound 155 | US9896458, No. 155)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ccn(Cc2ccccc2)n1
Show InChI InChI=1/C21H21N5O3/c1-14-18(21(28)25(2)19-17(29-14)9-6-11-22-19)23-20(27)16-10-12-26(24-16)13-15-7-4-3-5-8-15/h3-12,14,18H,13H2,1-2H3,(H,23,27)/t14-,18+/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356431
PNG
(US9815850, Compound 163 | US9896458, No. 163)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc(Cc3cccc(c3)C#N)[nH]2)C1=O
Show InChI InChI=1/C21H18N6O3/c1-27-16-7-2-3-8-17(16)30-12-15(21(27)29)23-20(28)19-24-18(25-26-19)10-13-5-4-6-14(9-13)11-22/h2-9,15H,10,12H2,1H3,(H,23,28)(H,24,25,26)/t15-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356461
PNG
(US9815850, Compound 188 | US9896458, No. 188)
Show SMILES CN1c2nccnc2CC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1/C20H19N5O3/c1-25-18-15(21-9-10-22-18)7-8-16(20(25)27)23-19(26)17-12-14(28-24-17)11-13-5-3-2-4-6-13/h2-6,9-10,12,16H,7-8,11H2,1H3,(H,23,26)/t16-/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356463
PNG
(US9815850, Compound 192 | US9896458, No. 192)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncc(Cc2ccccc2)o1
Show InChI InChI=1/C21H20N4O4/c1-13-17(21(27)25(2)18-16(28-13)9-6-10-22-18)24-19(26)20-23-12-15(29-20)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,26)/t13-,17+/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356473
PNG
(US9815850, Compound 205 | US9896458, No. 205)
Show SMILES C[C@H]1Oc2ncccc2N(C)C(=O)[C@H]1NC(=O)c1nn(Cc2ccccc2)cc1F
Show InChI InChI=1/C21H20FN5O3/c1-13-17(21(29)26(2)16-9-6-10-23-20(16)30-13)24-19(28)18-15(22)12-27(25-18)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,28)/t13-,17+/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356476
PNG
(US9815850, Compound 208 | US9896458, No. 208)
Show SMILES CN1c2nccnc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2cn(Cc3ccccc3)c(C)n2)C1=O
Show InChI InChI=1/C22H22N6O2/c1-13-25-17(12-28(13)11-14-6-4-3-5-7-14)21(29)26-19-16-10-15(16)18-20(24-9-8-23-18)27(2)22(19)30/h3-9,12,15-16,19H,10-11H2,1-2H3,(H,26,29)/t15-,16+,19+/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356488
PNG
(US9815850, Compound 223 | US9896458, No. 223)
Show SMILES CN1c2nccnc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccc(F)cc3)o2)C1=O
Show InChI InChI=1/C20H17FN6O3/c1-27-17-15(22-6-7-23-17)12-9-13(12)16(20(27)29)24-18(28)19-26-25-14(30-19)8-10-2-4-11(21)5-3-10/h2-7,12-13,16H,8-9H2,1H3,(H,24,28)/t12-,13+,16+/s2
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356489
PNG
(US9815850, Compound 224 | US9896458, No. 224)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ncccn3)cc2F)C1=O
Show InChI InChI=1/C19H17FN6O3/c1-25-14-5-2-3-6-15(14)29-11-13(19(25)28)23-18(27)17-12(20)9-26(24-17)10-16-21-7-4-8-22-16/h2-9,13H,10-11H2,1H3,(H,23,27)/t13-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356229
PNG
(US9815850, Compound 1B | US9896458, No. 1B)
Show SMILES CN1c2cc(Cl)sc2CC[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1/C20H18ClN3O3S/c1-24-16-11-18(21)28-17(16)8-7-14(20(24)26)22-19(25)15-10-13(27-23-15)9-12-5-3-2-4-6-12/h2-6,10-11,14H,7-9H2,1H3,(H,22,25)/t14-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356236
PNG
(US9815850, Compound 6 | US9896458, No. 6)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)c(C)c2F)C1=O
Show InChI InChI=1/C22H21FN4O3/c1-14-19(23)20(25-27(14)12-15-8-4-3-5-9-15)21(28)24-16-13-30-18-11-7-6-10-17(18)26(2)22(16)29/h3-11,16H,12-13H2,1-2H3,(H,24,28)/t16-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356240
PNG
(US9815850, Compound 8 | US9896458, No. 8)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc(on2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1/C23H21N3O4/c1-26-18-9-5-6-10-19(18)29-14-17(22(26)28)24-21(27)16-13-20(30-25-16)23(11-12-23)15-7-3-2-4-8-15/h2-10,13,17H,11-12,14H2,1H3,(H,24,27)/t17-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356249
PNG
(US9815850, Compound 13 | US9896458, No. 13)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc3[C@H](CCn3n2)c2ccccc2)C1=O
Show InChI InChI=1/C23H22N4O3/c1-26-19-9-5-6-10-21(19)30-14-18(23(26)29)24-22(28)17-13-20-16(11-12-27(20)25-17)15-7-3-2-4-8-15/h2-10,13,16,18H,11-12,14H2,1H3,(H,24,28)/t16-,18+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356268
PNG
(US9815850, Compound 38A | US9896458, No. 38A)
Show SMILES CN1c2nc(C)sc2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Show InChI InChI=1/C19H20N6O2S/c1-11-20-17-14(28-11)9-8-13(19(27)25(17)2)21-18(26)16-22-15(23-24-16)10-12-6-4-3-5-7-12/h3-7,13H,8-10H2,1-2H3,(H,21,26)(H,22,23,24)/t13-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%