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Patent code US9902710

Compile Data Set for Download or QSAR
Found 169 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194437
PNG
(US9200016, 119 | US9902710, Compound 119)
Show SMILES COCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H24N4O5S/c1-30-13-20-18-11-22(32-3)21(31-2)10-17(18)15(12-25-20)9-16-8-7-14-5-4-6-19(23(14)26-16)27-33(24,28)29/h4-8,10-12,27H,9,13H2,1-3H3,(H2,24,28,29)
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US Patent
n/an/a 0.180n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194477
PNG
(US9200016, 159 | US9902710, Compound 159)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC
Show InChI InChI=1S/C21H20N4O4S/c1-28-19-9-15-12-23-11-14(17(15)10-20(19)29-2)8-16-7-6-13-4-3-5-18(21(13)24-16)25-30(22,26)27/h3-7,9-12,25H,8H2,1-2H3,(H2,22,26,27)
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n/an/a 0.420n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194402
PNG
(US9200016, 84 | US9902710, Compound 84)
Show SMILES CCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H24N4O4S/c1-4-19-18-12-22(31-3)21(30-2)11-17(18)15(13-25-19)10-16-9-8-14-6-5-7-20(23(14)26-16)27-32(24,28)29/h5-9,11-13,27H,4,10H2,1-3H3,(H2,24,28,29)
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n/an/a 0.530n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194474
PNG
(US9200016, 156 | US9902710, Compound 156)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC
Show InChI InChI=1S/C22H22N4O4S/c1-13-17-10-20(29-2)21(30-3)11-18(17)15(12-24-13)9-16-8-7-14-5-4-6-19(22(14)25-16)26-31(23,27)28/h4-8,10-12,26H,9H2,1-3H3,(H2,23,27,28)
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n/an/a 0.710n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194403
PNG
(US9200016, 85 | US9902710, Compound 85)
Show SMILES CCCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H26N4O4S/c1-4-6-20-19-13-23(32-3)22(31-2)12-18(19)16(14-26-20)11-17-10-9-15-7-5-8-21(24(15)27-17)28-33(25,29)30/h5,7-10,12-14,28H,4,6,11H2,1-3H3,(H2,25,29,30)
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n/an/a 0.820n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194392
PNG
(US9200016, 74 | US9902710, Compound 74)
Show SMILES COc1cc2cncc(Cc3cnc4cc(C)ccc4c3)c2cc1OC
Show InChI InChI=1S/C22H20N2O2/c1-14-4-5-16-7-15(11-24-20(16)6-14)8-17-12-23-13-18-9-21(25-2)22(26-3)10-19(17)18/h4-7,9-13H,8H2,1-3H3
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n/an/a 1.20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194391
PNG
(US9200016, 139 | US9200016, 73 | US9902710, Compou...)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H27N3O4/c1-4-6-21-20-13-24(32-3)23(31-2)12-19(20)17(14-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)33-15-25(27)30/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H2,27,30)
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n/an/a 1.40n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194463
PNG
(US9200016, 145 | US9902710, Compound 145)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(cc3)C([O-])=O)c2cc1OC
Show InChI InChI=1S/C26H20N2O5/c1-31-23-11-19-14-27-13-18(20(19)12-24(23)32-2)9-15-3-8-22-21(10-15)28-25(33-22)16-4-6-17(7-5-16)26(29)30/h3-8,10-14H,9H2,1-2H3,(H,29,30)/p-1
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n/an/a 1.60n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194436
PNG
(US9200016, 118 | US9902710, Compound 118)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCCC([O-])=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H28N2O5/c1-4-6-22-21-15-25(33-3)24(32-2)14-20(21)18(16-28-22)13-19-10-9-17-7-5-8-23(27(17)29-19)34-12-11-26(30)31/h5,7-10,14-16H,4,6,11-13H2,1-3H3,(H,30,31)/p-1
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n/an/a 2.30n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194456
PNG
(US9200016, 138 | US9902710, Compound 138)
Show SMILES COc1cc2cncc(Cc3cnc4ccc(OCC(N)=O)cc4c3)c2cc1OC
Show InChI InChI=1S/C23H21N3O4/c1-28-21-8-17-12-25-11-16(19(17)9-22(21)29-2)6-14-5-15-7-18(30-13-23(24)27)3-4-20(15)26-10-14/h3-5,7-12H,6,13H2,1-2H3,(H2,24,27)
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n/an/a 2.5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194455
PNG
(US9200016, 137 | US9902710, Compound 137)
Show SMILES COc1cc2cncc(Cc3cnc4ccc(O)cc4c3)c2cc1OC
Show InChI InChI=1S/C21H18N2O3/c1-25-20-8-16-12-22-11-15(18(16)9-21(20)26-2)6-13-5-14-7-17(24)3-4-19(14)23-10-13/h3-5,7-12,24H,6H2,1-2H3
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n/an/a 2.90n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194416
PNG
(US9200016, 98 | US9902710, Compound 98)
Show SMILES CCc1ncc(Cc2cnc3ccc(NC(=O)C(N)=O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H24N4O4/c1-4-20-19-11-23(33-3)22(32-2)10-18(19)16(13-28-20)8-14-7-15-9-17(29-25(31)24(26)30)5-6-21(15)27-12-14/h5-7,9-13H,4,8H2,1-3H3,(H2,26,30)(H,29,31)
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n/an/a 3.5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194407
PNG
(US9200016, 89 | US9902710, Compound 89)
Show SMILES CCc1ncc(Cc2ccc3cccc(NS(=O)(=O)CC)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H27N3O4S/c1-5-21-20-14-24(32-4)23(31-3)13-19(20)17(15-26-21)12-18-11-10-16-8-7-9-22(25(16)27-18)28-33(29,30)6-2/h7-11,13-15,28H,5-6,12H2,1-4H3
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n/an/a 3.5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194399
PNG
(US9200016, 81 | US9902710, Compound 81)
Show SMILES COc1cc2cncc(Cc3ccc4n(C)c(=O)oc4c3)c2cc1OC
Show InChI InChI=1S/C20H18N2O4/c1-22-16-5-4-12(7-17(16)26-20(22)23)6-13-10-21-11-14-8-18(24-2)19(25-3)9-15(13)14/h4-5,7-11H,6H2,1-3H3
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n/an/a 3.60n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194423
PNG
(US9200016, 105 | US9902710, Compound 105)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4nc(C)ccc4c3)c2cc1OC
Show InChI InChI=1S/C23H22N2O2/c1-14-5-7-17-9-16(6-8-21(17)25-14)10-18-13-24-15(2)19-11-22(26-3)23(27-4)12-20(18)19/h5-9,11-13H,10H2,1-4H3
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n/an/a 4.30n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194400
PNG
(US9200016, 82 | US9902710, Compound 82)
Show SMILES CCCc1ncc(Cc2ccc3n(C)c(=O)oc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H24N2O4/c1-5-6-18-17-12-22(28-4)21(27-3)11-16(17)15(13-24-18)9-14-7-8-19-20(10-14)29-23(26)25(19)2/h7-8,10-13H,5-6,9H2,1-4H3
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n/an/a 4.40n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194487
PNG
(US9200016, 169 | US9902710, Compound 169)
Show SMILES COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H21F3N2O4/c1-31-12-19-16-9-22(33-3)21(32-2)8-15(16)14(11-29-19)6-13-7-17-18(28-10-13)4-5-20(30)23(17)24(25,26)27/h4-5,7-11,30H,6,12H2,1-3H3
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n/an/a 4.5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194418
PNG
(US9200016, 100 | US9902710, Compound 100)
Show SMILES CCc1ncc(Cc2cnc3ccc(NS(N)(=O)=O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H24N4O4S/c1-4-20-19-11-23(31-3)22(30-2)10-18(19)16(13-26-20)8-14-7-15-9-17(27-32(24,28)29)5-6-21(15)25-12-14/h5-7,9-13,27H,4,8H2,1-3H3,(H2,24,28,29)
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n/an/a 4.60n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194464
PNG
(US9200016, 146 | US9902710, Compound 146)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(cc3)C(O)=O)c2cc1OC
Show InChI InChI=1S/C26H20N2O5/c1-31-23-11-19-14-27-13-18(20(19)12-24(23)32-2)9-15-3-8-22-21(10-15)28-25(33-22)16-4-6-17(7-5-16)26(29)30/h3-8,10-14H,9H2,1-2H3,(H,29,30)
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n/an/a 4.70n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194439
PNG
(US9200016, 121 | US9902710, Compound 121)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCc4nnn[nH]4)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H26N6O3/c1-4-6-21-20-13-24(34-3)23(33-2)12-19(20)17(14-27-21)11-18-10-9-16-7-5-8-22(26(16)28-18)35-15-25-29-31-32-30-25/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H,29,30,31,32)
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n/an/a 4.70n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194426
PNG
(US9200016, 108 | US9902710, Compound 108)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H26N2O5/c1-4-6-21-20-13-24(32-3)23(31-2)12-19(20)17(14-27-21)11-18-10-9-16-7-5-8-22(26(16)28-18)33-15-25(29)30/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H,29,30)
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n/an/a 4.90n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194440
PNG
(US9200016, 122 | US9902710, Compound 122)
Show SMILES CCc1ncc(Cc2ccc3cccc(OCCC([O-])=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H26N2O5/c1-4-21-20-14-24(32-3)23(31-2)13-19(20)17(15-27-21)12-18-9-8-16-6-5-7-22(26(16)28-18)33-11-10-25(29)30/h5-9,13-15H,4,10-12H2,1-3H3,(H,29,30)/p-1
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n/an/a 5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194397
PNG
(US9200016, 79 | US9902710, Compound 79)
Show SMILES COc1cc2cncc(Cc3coc4ccc(C)cc4c3=O)c2cc1OC
Show InChI InChI=1S/C22H19NO4/c1-13-4-5-19-18(6-13)22(24)16(12-27-19)7-14-10-23-11-15-8-20(25-2)21(26-3)9-17(14)15/h4-6,8-12H,7H2,1-3H3
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n/an/a 5.10n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194387
PNG
(US9200016, 69 | US9902710, Compound 69)
Show SMILES CCCc1ncc(Cc2cnc3cc(C)ccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O2/c1-5-6-22-21-13-25(29-4)24(28-3)12-20(21)19(15-27-22)11-17-10-18-8-7-16(2)9-23(18)26-14-17/h7-10,12-15H,5-6,11H2,1-4H3
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n/an/a 5.20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194391
PNG
(US9200016, 139 | US9200016, 73 | US9902710, Compou...)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H27N3O4/c1-4-6-21-20-13-24(32-3)23(31-2)12-19(20)17(14-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)33-15-25(27)30/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H2,27,30)
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n/an/a 5.30n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194486
PNG
(US9200016, 168 | US9902710, Compound 168)
Show SMILES COCc1ncc(Cc2cnc3ccc(O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22N2O4/c1-27-13-21-19-10-23(29-3)22(28-2)9-18(19)16(12-25-21)7-14-6-15-8-17(26)4-5-20(15)24-11-14/h4-6,8-12,26H,7,13H2,1-3H3
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n/an/a 5.60n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194479
PNG
(US9200016, 161 | US9902710, Compound 161)
Show SMILES COc1cc2cncc(Cc3cnc4ccc(O)c(c4c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C22H17F3N2O3/c1-29-19-7-14-11-26-10-13(15(14)8-20(19)30-2)5-12-6-16-17(27-9-12)3-4-18(28)21(16)22(23,24)25/h3-4,6-11,28H,5H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM373566
PNG
(US9902710, Compound 48)
Show SMILES COc1cc2cncc(Cc3ccc4nc(C)ccc4n3)c2cc1OC
Show InChI InChI=1S/C21H19N3O2/c1-13-4-6-19-18(23-13)7-5-16(24-19)8-14-11-22-12-15-9-20(25-2)21(26-3)10-17(14)15/h4-7,9-12H,8H2,1-3H3
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n/an/a 6.5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194462
PNG
(US9200016, 144 | US9902710, Compound 144)
Show SMILES CCCc1ncc(Cc2cnc3ccc(OCC(N)=O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H27N3O4/c1-4-5-23-21-12-25(32-3)24(31-2)11-20(21)18(14-29-23)9-16-8-17-10-19(33-15-26(27)30)6-7-22(17)28-13-16/h6-8,10-14H,4-5,9,15H2,1-3H3,(H2,27,30)
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n/an/a 6.5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194393
PNG
(US9200016, 75 | US9902710, Compound 75)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCCO)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H28N2O4/c1-4-6-22-21-15-25(31-3)24(30-2)14-20(21)18(16-27-22)13-19-10-9-17-7-5-8-23(26(17)28-19)32-12-11-29/h5,7-10,14-16,29H,4,6,11-13H2,1-3H3
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n/an/a 6.60n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194435
PNG
(US9200016, 117 | US9902710, Compound 117)
Show SMILES COc1cc2c(C)ncc(Cc3cnc4cc(C)ccc4c3)c2cc1OC
Show InChI InChI=1S/C23H22N2O2/c1-14-5-6-17-8-16(12-25-21(17)7-14)9-18-13-24-15(2)19-10-22(26-3)23(27-4)11-20(18)19/h5-8,10-13H,9H2,1-4H3
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n/an/a 7.10n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194328
PNG
(US9200016, 10 | US9902710, Compound 10)
Show SMILES COc1cc2cncc(Cc3ccc4oc5ccccc5c4c3)c2cc1OC
Show InChI InChI=1S/C24H19NO3/c1-26-23-11-17-14-25-13-16(19(17)12-24(23)27-2)9-15-7-8-22-20(10-15)18-5-3-4-6-21(18)28-22/h3-8,10-14H,9H2,1-2H3
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n/an/a 7.60n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194425
PNG
(US9200016, 107 | US9902710, Compound 107)
Show SMILES CCn1c2cc(Cc3cncc4cc(OC)c(OC)cc34)ccc2oc1=O
Show InChI InChI=1S/C21H20N2O4/c1-4-23-17-8-13(5-6-18(17)27-21(23)24)7-14-11-22-12-15-9-19(25-2)20(26-3)10-16(14)15/h5-6,8-12H,4,7H2,1-3H3
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n/an/a 7.80n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194468
PNG
(US9200016, 150 | US9902710, Compound 150)
Show SMILES COc1cc2cncc(Cc3cnc4ccc(OCC(O)=O)cc4c3)c2cc1OC
Show InChI InChI=1S/C23H20N2O5/c1-28-21-8-17-12-24-11-16(19(17)9-22(21)29-2)6-14-5-15-7-18(30-13-23(26)27)3-4-20(15)25-10-14/h3-5,7-12H,6,13H2,1-2H3,(H,26,27)
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n/an/a 7.90n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194404
PNG
(US9200016, 86 | US9902710, Compound 86)
Show SMILES CCc1ncc(Cc2ccc3cccc(NS(C)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H25N3O4S/c1-5-20-19-13-23(31-3)22(30-2)12-18(19)16(14-25-20)11-17-10-9-15-7-6-8-21(24(15)26-17)27-32(4,28)29/h6-10,12-14,27H,5,11H2,1-4H3
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n/an/a 8.30n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194485
PNG
(US9200016, 167 | US9902710, Compound 167)
Show SMILES COCc1ncc(Cc2ccc3cccc(N)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H23N3O3/c1-27-13-20-18-11-22(29-3)21(28-2)10-17(18)15(12-25-20)9-16-8-7-14-5-4-6-19(24)23(14)26-16/h4-8,10-12H,9,13,24H2,1-3H3
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n/an/a 8.60n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194461
PNG
(US9200016, 143 | US9902710, Compound 143)
Show SMILES CCCc1ncc(Cc2cnc3ccc(O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O3/c1-4-5-22-20-12-24(29-3)23(28-2)11-19(20)17(14-26-22)9-15-8-16-10-18(27)6-7-21(16)25-13-15/h6-8,10-14,27H,4-5,9H2,1-3H3
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n/an/a 9.40n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194447
PNG
(US9200016, 129 | US9902710, Compound 129)
Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H29N3O3/c1-6-7-23-21-14-25(32-5)24(31-4)13-20(21)18(15-28-23)11-17-10-16-12-19(30-3)8-9-22(16)29-26(17)27-2/h8-10,12-15H,6-7,11H2,1-5H3,(H,27,29)
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n/an/a 9.5n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194395
PNG
(US9200016, 77 | US9902710, Compound 77)
Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H31N3O3/c1-6-8-24-22-15-26(33-5)25(32-4)14-21(22)19(16-29-24)12-18-11-17-13-20(31-3)9-10-23(17)30-27(18)28-7-2/h9-11,13-16H,6-8,12H2,1-5H3,(H,28,30)
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n/an/a 9.70n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194401
PNG
(US9200016, 83 | US9902710, Compound 83)
Show SMILES CCc1ncc(Cc2ccc3cccc(O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22N2O3/c1-4-19-18-12-22(28-3)21(27-2)11-17(18)15(13-24-19)10-16-9-8-14-6-5-7-20(26)23(14)25-16/h5-9,11-13,26H,4,10H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194362
PNG
(US9200016, 44 | US9902710, Compound 44)
Show SMILES CCCc1ncc(Cc2cnc3ccccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O2/c1-4-7-22-20-13-24(28-3)23(27-2)12-19(20)18(15-26-22)11-16-10-17-8-5-6-9-21(17)25-14-16/h5-6,8-10,12-15H,4,7,11H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194394
PNG
(US9200016, 106 | US9200016, 76 | US9902710, Compou...)
Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C29H34N4O4/c1-6-7-26-24-16-28(37-5)27(36-4)15-23(24)21(17-32-26)13-20-12-19-14-22(35-3)8-9-25(19)33-29(20)31-11-10-30-18(2)34/h8-9,12,14-17H,6-7,10-11,13H2,1-5H3,(H,30,34)(H,31,33)
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n/an/a 11n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194414
PNG
(US9200016, 96 | US9902710, Compound 96)
Show SMILES CCc1ncc(Cc2cnc3ccc(N)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H23N3O2/c1-4-20-19-11-23(28-3)22(27-2)10-18(19)16(13-26-20)8-14-7-15-9-17(24)5-6-21(15)25-12-14/h5-7,9-13H,4,8,24H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194480
PNG
(US9200016, 162 | US9902710, Compound 162)
Show SMILES CCCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H23F3N2O3/c1-4-5-19-17-11-23(33-3)22(32-2)10-16(17)15(13-30-19)8-14-9-18-20(29-12-14)6-7-21(31)24(18)25(26,27)28/h6-7,9-13,31H,4-5,8H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194320
PNG
(US9200016, 2 | US9902710, Compound 2)
Show SMILES COc1cc2cncc(Cc3cnc4ccccc4c3)c2cc1OC
Show InChI InChI=1S/C21H18N2O2/c1-24-20-9-17-13-22-12-16(18(17)10-21(20)25-2)8-14-7-15-5-3-4-6-19(15)23-11-14/h3-7,9-13H,8H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194412
PNG
(US9200016, 94 | US9902710, Compound 94)
Show SMILES CCc1ncc(Cc2ccc3cccc(CNS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H26N4O4S/c1-4-21-20-12-23(32-3)22(31-2)11-19(20)17(13-26-21)10-18-9-8-15-6-5-7-16(24(15)28-18)14-27-33(25,29)30/h5-9,11-13,27H,4,10,14H2,1-3H3,(H2,25,29,30)
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n/an/a 13n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194470
PNG
(US9200016, 152 | US9902710, Compound 152)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(N)c4n3)c2cc1OC
Show InChI InChI=1S/C22H21N3O2/c1-13-17-10-20(26-2)21(27-3)11-18(17)15(12-24-13)9-16-8-7-14-5-4-6-19(23)22(14)25-16/h4-8,10-12H,9,23H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194475
PNG
(US9200016, 157 | US9902710, Compound 157)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(N)c4n3)c2cc1OC
Show InChI InChI=1S/C21H19N3O2/c1-25-19-9-15-12-23-11-14(17(15)10-20(19)26-2)8-16-7-6-13-4-3-5-18(22)21(13)24-16/h3-7,9-12H,8,22H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM373685
PNG
(US9902710, Compound 160)
Show SMILES CCCc1ncc(Cc2ccc3cccc(NC(=O)CN)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H28N4O3/c1-4-6-21-20-13-24(33-3)23(32-2)12-19(20)17(15-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)30-25(31)14-27/h5,7-10,12-13,15H,4,6,11,14,27H2,1-3H3,(H,30,31)
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n/an/a 15n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194415
PNG
(US9200016, 97 | US9902710, Compound 97)
Show SMILES CCc1ncc(Cc2cnc3ccc(cc3c2)N2CCCC2=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H27N3O3/c1-4-23-22-14-26(33-3)25(32-2)13-21(22)19(16-29-23)11-17-10-18-12-20(7-8-24(18)28-15-17)30-9-5-6-27(30)31/h7-8,10,12-16H,4-6,9,11H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194417
PNG
(US9200016, 99 | US9902710, Compound 99)
Show SMILES CCc1ncc(Cc2cnc3ccc(NS(C)(=O)=O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H25N3O4S/c1-5-21-20-12-24(31-3)23(30-2)11-19(20)17(14-26-21)9-15-8-16-10-18(27-32(4,28)29)6-7-22(16)25-13-15/h6-8,10-14,27H,5,9H2,1-4H3
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n/an/a 16n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194406
PNG
(US9200016, 88 | US9902710, Compound 88)
Show SMILES CCc1ncc(Cc2ccc3cccc(NC(C)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H25N3O3/c1-5-21-20-13-24(31-4)23(30-3)12-19(20)17(14-26-21)11-18-10-9-16-7-6-8-22(25(16)28-18)27-15(2)29/h6-10,12-14H,5,11H2,1-4H3,(H,27,29)
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n/an/a 17n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194411
PNG
(US9200016, 93 | US9902710, Compound 93)
Show SMILES CCc1ncc(Cc2ccc3cccc(NC(=O)C(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H24N4O4/c1-4-19-18-12-22(33-3)21(32-2)11-17(18)15(13-27-19)10-16-9-8-14-6-5-7-20(23(14)28-16)29-25(31)24(26)30/h5-9,11-13H,4,10H2,1-3H3,(H2,26,30)(H,29,31)
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n/an/a 17n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194473
PNG
(US9200016, 155 | US9902710, Compound 155)
Show SMILES COc1cc2c(C)ncc(Cc3cnc4ccc(O)cc4c3)c2cc1OC
Show InChI InChI=1S/C22H20N2O3/c1-13-18-9-21(26-2)22(27-3)10-19(18)16(12-23-13)7-14-6-15-8-17(25)4-5-20(15)24-11-14/h4-6,8-12,25H,7H2,1-3H3
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n/an/a 18n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194326
PNG
(US9200016, 8 | US9902710, Compound 8)
Show SMILES COc1ccc2cc(Cc3cncc4cc(OC)c(OC)cc34)cnc2c1
Show InChI InChI=1S/C22H20N2O3/c1-25-18-5-4-15-6-14(11-24-20(15)9-18)7-16-12-23-13-17-8-21(26-2)22(27-3)10-19(16)17/h4-6,8-13H,7H2,1-3H3
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n/an/a 18n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194481
PNG
(US9200016, 163 | US9902710, Compound 163)
Show SMILES COCc1ncc(Cc2ccc3cccc(O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22N2O4/c1-27-13-19-18-11-22(29-3)21(28-2)10-17(18)15(12-24-19)9-16-8-7-14-5-4-6-20(26)23(14)25-16/h4-8,10-12,26H,9,13H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194368
PNG
(US9200016, 50 | US9902710, Compound 50)
Show SMILES CCc1ncc(Cc2cnc3ccccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22N2O2/c1-4-20-19-12-23(27-3)22(26-2)11-18(19)17(14-25-20)10-15-9-16-7-5-6-8-21(16)24-13-15/h5-9,11-14H,4,10H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194460
PNG
(US9200016, 142 | US9902710, Compound 142)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(CO)cc3)c2cc1OC
Show InChI InChI=1S/C26H22N2O4/c1-30-24-11-20-14-27-13-19(21(20)12-25(24)31-2)9-17-5-8-23-22(10-17)28-26(32-23)18-6-3-16(15-29)4-7-18/h3-8,10-14,29H,9,15H2,1-2H3
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n/an/a 19n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194363
PNG
(US9200016, 45 | US9902710, Compound 45)
Show SMILES CCCc1ncc(Cc2ccc3cccc(O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O3/c1-4-6-20-19-13-23(29-3)22(28-2)12-18(19)16(14-25-20)11-17-10-9-15-7-5-8-21(27)24(15)26-17/h5,7-10,12-14,27H,4,6,11H2,1-3H3
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n/an/a 20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194488
PNG
(US9200016, 170 | US9902710, Compound 170)
Show SMILES COc1cc2cncc(Cc3ccc4nc(oc4c3)-c3ccc(CO)cc3)c2cc1OC
Show InChI InChI=1S/C26H22N2O4/c1-30-24-11-20-14-27-13-19(21(20)12-25(24)31-2)9-17-5-8-22-23(10-17)32-26(28-22)18-6-3-16(15-29)4-7-18/h3-8,10-14,29H,9,15H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194375
PNG
(US9200016, 57 | US9902710, Compound 57)
Show SMILES CCCc1ncc(Cc2ccc3nc(C)ccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O2/c1-5-6-23-21-14-25(29-4)24(28-3)13-20(21)19(15-26-23)12-17-8-10-22-18(11-17)9-7-16(2)27-22/h7-11,13-15H,5-6,12H2,1-4H3
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n/an/a 20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194421
PNG
(US9200016, 103 | US9902710, Compound 103)
Show SMILES COc1cc2cncc(Cc3coc4ccc(Cl)cc4c3=O)c2cc1OC
Show InChI InChI=1S/C21H16ClNO4/c1-25-19-6-13-10-23-9-12(16(13)8-20(19)26-2)5-14-11-27-18-4-3-15(22)7-17(18)21(14)24/h3-4,6-11H,5H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194434
PNG
(US9200016, 116 | US9902710, Compound 116)
Show SMILES CCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H25N3O4/c1-4-20-19-12-23(31-3)22(30-2)11-18(19)16(13-27-20)10-17-9-8-15-6-5-7-21(25(15)28-17)32-14-24(26)29/h5-9,11-13H,4,10,14H2,1-3H3,(H2,26,29)
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n/an/a 20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194379
PNG
(US9200016, 61 | US9902710, Compound 61)
Show SMILES COc1cc2c(Cc3cnc4ccccc4c3)cnc(CC(C)C)c2cc1OC
Show InChI InChI=1S/C25H26N2O2/c1-16(2)9-23-21-13-25(29-4)24(28-3)12-20(21)19(15-27-23)11-17-10-18-7-5-6-8-22(18)26-14-17/h5-8,10,12-16H,9,11H2,1-4H3
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n/an/a 20n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194482
PNG
(US9200016, 164 | US9902710, Compound 164)
Show SMILES COCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H25N3O5/c1-30-13-20-19-11-23(32-3)22(31-2)10-18(19)16(12-27-20)9-17-8-7-15-5-4-6-21(25(15)28-17)33-14-24(26)29/h4-8,10-12H,9,13-14H2,1-3H3,(H2,26,29)
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n/an/a 21n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194364
PNG
(US9200016, 46 | US9902710, Compound 46)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(OCC(N)=O)c4n3)c2cc1OC
Show InChI InChI=1S/C23H21N3O4/c1-28-20-9-16-12-25-11-15(18(16)10-21(20)29-2)8-17-7-6-14-4-3-5-19(23(14)26-17)30-13-22(24)27/h3-7,9-12H,8,13H2,1-2H3,(H2,24,27)
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n/an/a 21n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194325
PNG
(US9200016, 7 | US9902710, Compound 7)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(O)c4n3)c2cc1OC
Show InChI InChI=1S/C21H18N2O3/c1-25-19-9-15-12-22-11-14(17(15)10-20(19)26-2)8-16-7-6-13-4-3-5-18(24)21(13)23-16/h3-7,9-12,24H,8H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194371
PNG
(US9200016, 53 | US9902710, Compound 53)
Show SMILES COc1ccc2nc(O)c(Cc3cncc4cc(OC)c(OC)cc34)cc2c1
Show InChI InChI=1S/C22H20N2O4/c1-26-17-4-5-19-13(8-17)6-14(22(25)24-19)7-15-11-23-12-16-9-20(27-2)21(28-3)10-18(15)16/h4-6,8-12H,7H2,1-3H3,(H,24,25)
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n/an/a 25n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194396
PNG
(US9200016, 78 | US9902710, Compound 78)
Show SMILES COc1cc2c(Cc3ccc4nc(C)ccc4c3)cnc(C3CC3)c2cc1OC
Show InChI InChI=1S/C25H24N2O2/c1-15-4-6-18-10-16(5-9-22(18)27-15)11-19-14-26-25(17-7-8-17)21-13-24(29-3)23(28-2)12-20(19)21/h4-6,9-10,12-14,17H,7-8,11H2,1-3H3
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n/an/a 25n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM373533
PNG
(US9902710, Compound 14)
Show SMILES CCn1c2ccccc2c2cc(Cc3cncc4cc(OC)c(OC)cc34)ccc12
Show InChI InChI=1S/C26H24N2O2/c1-4-28-23-8-6-5-7-20(23)22-12-17(9-10-24(22)28)11-18-15-27-16-19-13-25(29-2)26(30-3)14-21(18)19/h5-10,12-16H,4,11H2,1-3H3
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n/an/a 26n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194422
PNG
(US9200016, 104 | US9902710, Compound 104)
Show SMILES COc1cc2cncc(Cc3coc4c(Cl)cc(Cl)cc4c3=O)c2cc1OC
Show InChI InChI=1S/C21H15Cl2NO4/c1-26-18-4-12-9-24-8-11(15(12)7-19(18)27-2)3-13-10-28-21-16(20(13)25)5-14(22)6-17(21)23/h4-10H,3H2,1-2H3
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n/an/a 27n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194376
PNG
(US9200016, 58 | US9902710, Compound 58)
Show SMILES CCc1ncc(Cc2ccc3nc(C)ccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O2/c1-5-21-20-13-24(28-4)23(27-3)12-19(20)18(14-25-21)11-16-7-9-22-17(10-16)8-6-15(2)26-22/h6-10,12-14H,5,11H2,1-4H3
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n/an/a 28n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194469
PNG
(US9200016, 151 | US9902710, Compound 151)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3cccc(CO)c3)c2cc1OC
Show InChI InChI=1S/C26H22N2O4/c1-30-24-11-20-14-27-13-19(21(20)12-25(24)31-2)8-16-6-7-23-22(10-16)28-26(32-23)18-5-3-4-17(9-18)15-29/h3-7,9-14,29H,8,15H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194413
PNG
(US9200016, 95 | US9902710, Compound 95)
Show SMILES CCc1ncc(Cc2cnc3ccc(O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22N2O3/c1-4-20-19-11-23(28-3)22(27-2)10-18(19)16(13-25-20)8-14-7-15-9-17(26)5-6-21(15)24-12-14/h5-7,9-13,26H,4,8H2,1-3H3
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n/an/a 28n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194484
PNG
(US9200016, 166 | US9902710, Compound 166)
Show SMILES COCc1ncc(Cc2ccc3cccc(OCCO)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O5/c1-29-15-21-20-13-24(31-3)23(30-2)12-19(20)17(14-26-21)11-18-8-7-16-5-4-6-22(25(16)27-18)32-10-9-28/h4-8,12-14,28H,9-11,15H2,1-3H3
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n/an/a 28n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM373625
PNG
(US9902710, Compound 106)
Show SMILES COc1cc2cncc(Cc3ccc4oc(=O)[nH]c4c3)c2cc1OC
Show InChI InChI=1S/C19H16N2O4/c1-23-17-7-13-10-20-9-12(14(13)8-18(17)24-2)5-11-3-4-16-15(6-11)21-19(22)25-16/h3-4,6-10H,5H2,1-2H3,(H,21,22)
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n/an/a 28n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194384
PNG
(US9200016, 66 | US9902710, Compound 66)
Show SMILES COc1cc2cncc(Cc3cc4ccccc4cn3)c2cc1OC
Show InChI InChI=1S/C21H18N2O2/c1-24-20-9-17-12-22-11-16(19(17)10-21(20)25-2)8-18-7-14-5-3-4-6-15(14)13-23-18/h3-7,9-13H,8H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194386
PNG
(US9200016, 68 | US9902710, Compound 68)
Show SMILES COc1cc2c(Cc3ccc4nc(C)ccc4c3)cnc(CC(C)C)c2cc1OC
Show InChI InChI=1S/C26H28N2O2/c1-16(2)10-24-22-14-26(30-5)25(29-4)13-21(22)20(15-27-24)12-18-7-9-23-19(11-18)8-6-17(3)28-23/h6-9,11,13-16H,10,12H2,1-5H3
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n/an/a 31n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194353
PNG
(US9200016, 35 | US9902710, Compound 35)
Show SMILES COc1cc2c[n+]([O-])cc(Cc3ccc4oc5ccccc5c4c3)c2cc1OC
Show InChI InChI=1S/C24H19NO4/c1-27-23-11-17-14-25(26)13-16(19(17)12-24(23)28-2)9-15-7-8-22-20(10-15)18-5-3-4-6-21(18)29-22/h3-8,10-14H,9H2,1-2H3
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n/an/a 31n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194445
PNG
(US9200016, 127 | US9902710, Compound 127)
Show SMILES CCc1ncc(Cc2ccc3cccc(OCc4nnn[nH]4)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H24N6O3/c1-4-20-19-12-23(33-3)22(32-2)11-18(19)16(13-26-20)10-17-9-8-15-6-5-7-21(25(15)27-17)34-14-24-28-30-31-29-24/h5-9,11-13H,4,10,14H2,1-3H3,(H,28,29,30,31)
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n/an/a 31n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194428
PNG
(US9200016, 110 | US9902710, Compound 110)
Show SMILES CCCc1ncc(Cc2coc3ccc(C)cc3c2=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H25NO4/c1-5-6-21-19-12-24(29-4)23(28-3)11-18(19)16(13-26-21)10-17-14-30-22-8-7-15(2)9-20(22)25(17)27/h7-9,11-14H,5-6,10H2,1-4H3
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n/an/a 31n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194390
PNG
(US9200016, 72 | US9902710, Compound 72)
Show SMILES CCc1ncc(Cc2cc3ccccc3cn2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22N2O2/c1-4-21-20-12-23(27-3)22(26-2)11-19(20)17(14-25-21)10-18-9-15-7-5-6-8-16(15)13-24-18/h5-9,11-14H,4,10H2,1-3H3
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n/an/a 32n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194430
PNG
(US9200016, 112 | US9902710, Compound 112)
Show SMILES CCn1c2ccc(Cc3cncc4cc(OC)c(OC)cc34)cc2oc1=O
Show InChI InChI=1S/C21H20N2O4/c1-4-23-17-6-5-13(8-18(17)27-21(23)24)7-14-11-22-12-15-9-19(25-2)20(26-3)10-16(14)15/h5-6,8-12H,4,7H2,1-3H3
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n/an/a 32n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194431
PNG
(US9200016, 113 | US9902710, Compound 113)
Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1cncc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H25N3O3/c1-5-26-24-16(8-15-10-19(28-2)6-7-21(15)27-24)9-17-13-25-14-18-11-22(29-3)23(30-4)12-20(17)18/h6-8,10-14H,5,9H2,1-4H3,(H,26,27)
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n/an/a 32n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194429
PNG
(US9200016, 111 | US9902710, Compound 111)
Show SMILES COc1cc2cncc(Cc3ccc4[nH]c(=O)oc4c3)c2cc1OC
Show InChI InChI=1S/C19H16N2O4/c1-23-17-7-13-10-20-9-12(14(13)8-18(17)24-2)5-11-3-4-15-16(6-11)25-19(22)21-15/h3-4,6-10H,5H2,1-2H3,(H,21,22)
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n/an/a 34n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194365
PNG
(US9200016, 47 | US9902710, Compound 47)
Show SMILES CCCc1ncc(Cc2cc3ccccc3nc2O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O3/c1-4-7-21-19-13-23(29-3)22(28-2)12-18(19)17(14-25-21)11-16-10-15-8-5-6-9-20(15)26-24(16)27/h5-6,8-10,12-14H,4,7,11H2,1-3H3,(H,26,27)
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n/an/a 36n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194420
PNG
(US9200016, 102 | US9902710, Compound 102)
Show SMILES COc1cc2cncc(Cc3coc4ccc(F)cc4c3=O)c2cc1OC
Show InChI InChI=1S/C21H16FNO4/c1-25-19-6-13-10-23-9-12(16(13)8-20(19)26-2)5-14-11-27-18-4-3-15(22)7-17(18)21(14)24/h3-4,6-11H,5H2,1-2H3
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n/an/a 38n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194361
PNG
(US9200016, 43 | US9902710, Compound 43)
Show SMILES COc1cc2cnc(C)c(Cc3cnc4ccccc4c3)c2cc1OC
Show InChI InChI=1S/C22H20N2O2/c1-14-18(9-15-8-16-6-4-5-7-20(16)24-12-15)19-11-22(26-3)21(25-2)10-17(19)13-23-14/h4-8,10-13H,9H2,1-3H3
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n/an/a 39n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194398
PNG
(US9200016, 80 | US9902710, Compound 80)
Show SMILES COc1cc2cncc(Cc3coc4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C21H17NO4/c1-24-19-8-14-11-22-10-13(17(14)9-20(19)25-2)7-15-12-26-18-6-4-3-5-16(18)21(15)23/h3-6,8-12H,7H2,1-2H3
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n/an/a 41n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194442
PNG
(US9200016, 124 | US9902710, Compound 124)
Show SMILES COc1cc2cnc(C)c(Cc3ccc4cccc(O)c4n3)c2cc1OC
Show InChI InChI=1S/C22H20N2O3/c1-13-17(10-16-8-7-14-5-4-6-19(25)22(14)24-16)18-11-21(27-3)20(26-2)9-15(18)12-23-13/h4-9,11-12,25H,10H2,1-3H3
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n/an/a 41n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194380
PNG
(US9200016, 62 | US9902710, Compound 62)
Show SMILES COc1cc2c(Cc3cnc4ccccc4c3)cnc(C3CC3)c2cc1OC
Show InChI InChI=1S/C24H22N2O2/c1-27-22-11-19-18(10-15-9-17-5-3-4-6-21(17)25-13-15)14-26-24(16-7-8-16)20(19)12-23(22)28-2/h3-6,9,11-14,16H,7-8,10H2,1-2H3
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n/an/a 42n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194449
PNG
(US9200016, 131 | US9902710, Compound 131)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(O)c4n3)c2cc1OC
Show InChI InChI=1S/C22H20N2O3/c1-13-17-10-20(26-2)21(27-3)11-18(17)15(12-23-13)9-16-8-7-14-5-4-6-19(25)22(14)24-16/h4-8,10-12,25H,9H2,1-3H3
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n/an/a 42n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194360
PNG
(US9200016, 42 | US9902710, Compound 42)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(OCCO)c4n3)c2cc1OC
Show InChI InChI=1S/C23H22N2O4/c1-27-21-11-17-14-24-13-16(19(17)12-22(21)28-2)10-18-7-6-15-4-3-5-20(23(15)25-18)29-9-8-26/h3-7,11-14,26H,8-10H2,1-2H3
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n/an/a 42n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194419
PNG
(US9200016, 101 | US9902710, Compound 101)
Show SMILES CCc1ncc(Cc2cnc3ccc(cc3c2)N(C)S(C)(=O)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H27N3O4S/c1-6-22-21-13-25(32-4)24(31-3)12-20(21)18(15-27-22)10-16-9-17-11-19(28(2)33(5,29)30)7-8-23(17)26-14-16/h7-9,11-15H,6,10H2,1-5H3
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n/an/a 43n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194369
PNG
(US9200016, 51 | US9902710, Compound 51)
Show SMILES CCc1ncc(Cc2cc3cc(OC)ccc3nc2O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O4/c1-5-20-19-12-23(30-4)22(29-3)11-18(19)16(13-25-20)9-15-8-14-10-17(28-2)6-7-21(14)26-24(15)27/h6-8,10-13H,5,9H2,1-4H3,(H,26,27)
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n/an/a 44n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194339
PNG
(US9200016, 21 | US9902710, Compound 21)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(OC)c4n3)c2cc1OC
Show InChI InChI=1S/C22H20N2O3/c1-25-19-6-4-5-14-7-8-17(24-22(14)19)9-15-12-23-13-16-10-20(26-2)21(27-3)11-18(15)16/h4-8,10-13H,9H2,1-3H3
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n/an/a 46n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194408
PNG
(US9200016, 90 | US9902710, Compound 90)
Show SMILES CCc1ncc(Cc2ccc3cccc(C#N)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H21N3O2/c1-4-21-20-12-23(29-3)22(28-2)11-19(20)17(14-26-21)10-18-9-8-15-6-5-7-16(13-25)24(15)27-18/h5-9,11-12,14H,4,10H2,1-3H3
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n/an/a 46n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194345
PNG
(US9200016, 27 | US9902710, Compound 27)
Show SMILES CCOc1cccc2ccc(Cc3cncc4cc(OC)c(OC)cc34)nc12
Show InChI InChI=1S/C23H22N2O3/c1-4-28-20-7-5-6-15-8-9-18(25-23(15)20)10-16-13-24-14-17-11-21(26-2)22(27-3)12-19(16)17/h5-9,11-14H,4,10H2,1-3H3
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n/an/a 49n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194467
PNG
(US9200016, 149 | US9902710, Compound 149)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(N)cc3)c2cc1OC
Show InChI InChI=1S/C25H21N3O3/c1-29-23-11-18-14-27-13-17(20(18)12-24(23)30-2)9-15-3-8-22-21(10-15)28-25(31-22)16-4-6-19(26)7-5-16/h3-8,10-14H,9,26H2,1-2H3
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n/an/a 49n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194344
PNG
(US9200016, 26 | US9902710, Compound 26)
Show SMILES COc1cc2c(C)ncc(Cc3cnc4ccccc4c3)c2cc1OC
Show InChI InChI=1S/C22H20N2O2/c1-14-18-10-21(25-2)22(26-3)11-19(18)17(13-23-14)9-15-8-16-6-4-5-7-20(16)24-12-15/h4-8,10-13H,9H2,1-3H3
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n/an/a 49n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194443
PNG
(US9200016, 125 | US9902710, Compound 125)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(=O)NC)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H29N3O4/c1-5-7-22-21-14-25(33-4)24(32-3)13-20(21)18(15-29-22)12-19-11-10-17-8-6-9-23(27(17)30-19)34-16-26(31)28-2/h6,8-11,13-15H,5,7,12,16H2,1-4H3,(H,28,31)
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n/an/a 51n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194359
PNG
(US9200016, 41 | US9902710, Compound 41)
Show SMILES CCOC(=O)COc1cccc2ccc(Cc3cncc4cc(OC)c(OC)cc34)nc12
Show InChI InChI=1S/C25H24N2O5/c1-4-31-24(28)15-32-21-7-5-6-16-8-9-19(27-25(16)21)10-17-13-26-14-18-11-22(29-2)23(30-3)12-20(17)18/h5-9,11-14H,4,10,15H2,1-3H3
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n/an/a 51n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194327
PNG
(US9200016, 9 | US9902710, Compound 9)
Show SMILES COc1ccc2cc(Cc3cncc4cc(OC)c(OC)cc34)ccc2c1
Show InChI InChI=1S/C23H21NO3/c1-25-20-7-6-16-8-15(4-5-17(16)10-20)9-18-13-24-14-19-11-22(26-2)23(27-3)12-21(18)19/h4-8,10-14H,9H2,1-3H3
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n/an/a 54n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194324
PNG
(US9200016, 6 | US9902710, Compound 6)
Show SMILES COc1cc2cncc(Cc3ccc4ncccc4c3)c2cc1OC
Show InChI InChI=1S/C21H18N2O2/c1-24-20-10-17-13-22-12-16(18(17)11-21(20)25-2)9-14-5-6-19-15(8-14)4-3-7-23-19/h3-8,10-13H,9H2,1-2H3
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n/an/a 54n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194427
PNG
(US9200016, 109 | US9902710, Compound 109)
Show SMILES CCCc1ncc(Cc2coc3ccc(F)cc3c2=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H22FNO4/c1-4-5-20-18-11-23(29-3)22(28-2)10-17(18)14(12-26-20)8-15-13-30-21-7-6-16(25)9-19(21)24(15)27/h6-7,9-13H,4-5,8H2,1-3H3
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n/an/a 54n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194405
PNG
(US9200016, 87 | US9902710, Compound 87)
Show SMILES CCc1ncc(Cc2ccc3cccc(NC(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N4O3/c1-4-19-18-12-22(31-3)21(30-2)11-17(18)15(13-26-19)10-16-9-8-14-6-5-7-20(23(14)27-16)28-24(25)29/h5-9,11-13H,4,10H2,1-3H3,(H3,25,28,29)
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n/an/a 58n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194454
PNG
(US9200016, 136 | US9902710, Compound 136)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCCNC(C)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H31N3O4/c1-5-7-24-23-16-27(34-4)26(33-3)15-22(23)20(17-30-24)14-21-11-10-19-8-6-9-25(28(19)31-21)35-13-12-29-18(2)32/h6,8-11,15-17H,5,7,12-14H2,1-4H3,(H,29,32)
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n/an/a 58n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194446
PNG
(US9200016, 128 | US9902710, Compound 128)
Show SMILES CCOC(=O)COc1cccc2ccc(Cc3cnc(CC)c4cc(OC)c(OC)cc34)nc12
Show InChI InChI=1S/C27H28N2O5/c1-5-22-21-14-25(32-4)24(31-3)13-20(21)18(15-28-22)12-19-11-10-17-8-7-9-23(27(17)29-19)34-16-26(30)33-6-2/h7-11,13-15H,5-6,12,16H2,1-4H3
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n/an/a 59n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM373658
PNG
(US9902710, Compound 134)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OC(C)(C)C(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H31N3O4/c1-6-8-22-21-15-25(34-5)24(33-4)14-20(21)18(16-30-22)13-19-12-11-17-9-7-10-23(26(17)31-19)35-28(2,3)27(29)32/h7,9-12,14-16H,6,8,13H2,1-5H3,(H2,29,32)
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n/an/a 59n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194433
PNG
(US9200016, 115 | US9902710, Compound 115)
Show SMILES COC(=O)c1ccc(cc1)-c1nc2cc(Cc3cncc4cc(OC)c(OC)cc34)ccc2o1
Show InChI InChI=1S/C27H22N2O5/c1-31-24-12-20-15-28-14-19(21(20)13-25(24)32-2)10-16-4-9-23-22(11-16)29-26(34-23)17-5-7-18(8-6-17)27(30)33-3/h4-9,11-15H,10H2,1-3H3
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n/an/a 61n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194489
PNG
(US9200016, 171 | US9902710, Compound 171)
Show SMILES CCCc1ncc(Cc2cnc3ccc(OP([O-])([O-])=O)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H25N2O6P/c1-4-5-22-20-12-24(31-3)23(30-2)11-19(20)17(14-26-22)9-15-8-16-10-18(32-33(27,28)29)6-7-21(16)25-13-15/h6-8,10-14H,4-5,9H2,1-3H3,(H2,27,28,29)/p-2
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n/an/a 62n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194367
PNG
(US9200016, 49 | US9902710, Compound 49)
Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O4/c1-5-6-22-20-13-24(31-4)23(30-3)12-19(20)17(14-26-22)10-16-9-15-11-18(29-2)7-8-21(15)27-25(16)28/h7-9,11-14H,5-6,10H2,1-4H3,(H,27,28)
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n/an/a 63n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194465
PNG
(US9200016, 147 | US9902710, Compound 147)
Show SMILES CCCc1ncc(Cc2ccc3oc(=O)[nH]c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C22H22N2O4/c1-4-5-17-16-11-21(27-3)20(26-2)10-15(16)14(12-23-17)8-13-6-7-19-18(9-13)24-22(25)28-19/h6-7,9-12H,4-5,8H2,1-3H3,(H,24,25)
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n/an/a 64n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194438
PNG
(US9200016, 120 | US9902710, Compound 120)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(OCC(N)=O)c4n3)c2cc1OC
Show InChI InChI=1S/C24H23N3O4/c1-14-18-10-21(29-2)22(30-3)11-19(18)16(12-26-14)9-17-8-7-15-5-4-6-20(24(15)27-17)31-13-23(25)28/h4-8,10-12H,9,13H2,1-3H3,(H2,25,28)
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n/an/a 64n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194374
PNG
(US9200016, 56 | US9902710, Compound 56)
Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2OCCNC(C)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C29H33N3O5/c1-6-7-26-24-16-28(36-5)27(35-4)15-23(24)21(17-31-26)13-20-12-19-14-22(34-3)8-9-25(19)32-29(20)37-11-10-30-18(2)33/h8-9,12,14-17H,6-7,10-11,13H2,1-5H3,(H,30,33)
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n/an/a 65n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194448
PNG
(US9200016, 130 | US9902710, Compound 130)
Show SMILES COc1cc2c(Cc3ccc4cccc(OCC(N)=O)c4n3)cnc(C3CC3)c2cc1OC
Show InChI InChI=1S/C26H25N3O4/c1-31-22-11-19-17(13-28-25(16-6-7-16)20(19)12-23(22)32-2)10-18-9-8-15-4-3-5-21(26(15)29-18)33-14-24(27)30/h3-5,8-9,11-13,16H,6-7,10,14H2,1-2H3,(H2,27,30)
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n/an/a 67n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194330
PNG
(US9200016, 12 | US9902710, Compound 12)
Show SMILES COc1cc2cncc(Cc3ccc4N(C)CCOc4c3)c2cc1OC
Show InChI InChI=1S/C21H22N2O3/c1-23-6-7-26-19-9-14(4-5-18(19)23)8-15-12-22-13-16-10-20(24-2)21(25-3)11-17(15)16/h4-5,9-13H,6-8H2,1-3H3
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n/an/a 70n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194444
PNG
(US9200016, 126 | US9902710, Compound 126)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(=O)NC4CC4)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C29H31N3O4/c1-4-6-24-23-15-27(35-3)26(34-2)14-22(23)19(16-30-24)13-21-10-9-18-7-5-8-25(29(18)32-21)36-17-28(33)31-20-11-12-20/h5,7-10,14-16,20H,4,6,11-13,17H2,1-3H3,(H,31,33)
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n/an/a 71n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194483
PNG
(US9200016, 165 | US9902710, Compound 165)
Show SMILES CCOC(=O)COc1cccc2ccc(Cc3cnc(COC)c4cc(OC)c(OC)cc34)nc12
Show InChI InChI=1S/C27H28N2O6/c1-5-34-26(30)16-35-23-8-6-7-17-9-10-19(29-27(17)23)11-18-14-28-22(15-31-2)21-13-25(33-4)24(32-3)12-20(18)21/h6-10,12-14H,5,11,15-16H2,1-4H3
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n/an/a 71n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194333
PNG
(US9200016, 15 | US9902710, Compound 15)
Show SMILES COc1cc2cncc(Cc3ccc4[nH]cnc4c3)c2cc1OC
Show InChI InChI=1S/C19H17N3O2/c1-23-18-7-14-10-20-9-13(15(14)8-19(18)24-2)5-12-3-4-16-17(6-12)22-11-21-16/h3-4,6-11H,5H2,1-2H3,(H,21,22)
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n/an/a 74n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194409
PNG
(US9200016, 91 | US9902710, Compound 91)
Show SMILES CCc1ncc(Cc2ccc3cccc(C(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H23N3O3/c1-4-20-19-12-22(30-3)21(29-2)11-18(19)15(13-26-20)10-16-9-8-14-6-5-7-17(24(25)28)23(14)27-16/h5-9,11-13H,4,10H2,1-3H3,(H2,25,28)
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n/an/a 77n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194352
PNG
(US9200016, 34 | US9902710, Compound 34)
Show SMILES COc1cc2cncc(Cc3ccc4OC(C)(C)CCc4c3)c2cc1OC
Show InChI InChI=1S/C23H25NO3/c1-23(2)8-7-16-9-15(5-6-20(16)27-23)10-17-13-24-14-18-11-21(25-3)22(26-4)12-19(17)18/h5-6,9,11-14H,7-8,10H2,1-4H3
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n/an/a 81n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194466
PNG
(US9200016, 148 | US9902710, Compound 148)
Show SMILES CCCc1ncc(Cc2ccc3oc(=O)n(CC(N)=O)c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H25N3O5/c1-4-5-18-17-11-22(31-3)21(30-2)10-16(17)15(12-26-18)8-14-6-7-20-19(9-14)27(13-23(25)28)24(29)32-20/h6-7,9-12H,4-5,8,13H2,1-3H3,(H2,25,28)
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n/an/a 87n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194342
PNG
(US9200016, 24 | US9902710, Compound 24)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(OCc5cccnc5)c4n3)c2cc1OC
Show InChI InChI=1S/C27H23N3O3/c1-31-25-12-21-16-29-15-20(23(21)13-26(25)32-2)11-22-9-8-19-6-3-7-24(27(19)30-22)33-17-18-5-4-10-28-14-18/h3-10,12-16H,11,17H2,1-2H3
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n/an/a 90n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194349
PNG
(US9200016, 31 | US9902710, Compound 31)
Show SMILES CCOc1cc2c(Cc3cnc4ccccc4c3)cncc2cc1OC
Show InChI InChI=1S/C22H20N2O2/c1-3-26-22-11-19-17(13-23-14-18(19)10-21(22)25-2)9-15-8-16-6-4-5-7-20(16)24-12-15/h4-8,10-14H,3,9H2,1-2H3
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n/an/a 92n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194382
PNG
(US9200016, 64 | US9902710, Compound 64)
Show SMILES CCCCc1ncc(Cc2cnc3ccccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O2/c1-4-5-9-23-21-14-25(29-3)24(28-2)13-20(21)19(16-27-23)12-17-11-18-8-6-7-10-22(18)26-15-17/h6-8,10-11,13-16H,4-5,9,12H2,1-3H3
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n/an/a 92n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194337
PNG
(US9200016, 19 | US9902710, Compound 19)
Show SMILES COc1cc2cncc(Cc3cc4ccccc4nc3Cl)c2cc1OC
Show InChI InChI=1S/C21H17ClN2O2/c1-25-19-9-16-12-23-11-15(17(16)10-20(19)26-2)8-14-7-13-5-3-4-6-18(13)24-21(14)22/h3-7,9-12H,8H2,1-2H3
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n/an/a 95n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194472
PNG
(US9200016, 154 | US9902710, Compound 154)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccccc3CO)c2cc1OC
Show InChI InChI=1S/C26H22N2O4/c1-30-24-11-19-14-27-13-18(21(19)12-25(24)31-2)9-16-7-8-23-22(10-16)28-26(32-23)20-6-4-3-5-17(20)15-29/h3-8,10-14,29H,9,15H2,1-2H3
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n/an/a 95n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194370
PNG
(US9200016, 52 | US9902710, Compound 52)
Show SMILES CCCc1ncc(Cc2cc3cc(OCC)ccc3nc2O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H28N2O4/c1-5-7-23-21-14-25(31-4)24(30-3)13-20(21)18(15-27-23)11-17-10-16-12-19(32-6-2)8-9-22(16)28-26(17)29/h8-10,12-15H,5-7,11H2,1-4H3,(H,28,29)
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n/an/a 99n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194321
PNG
(US9200016, 3 | US9902710, Compound 3)
Show SMILES COc1cc2cncc(Cc3ccc4sccc4c3)c2cc1OC
Show InChI InChI=1S/C20H17NO2S/c1-22-18-9-16-12-21-11-15(17(16)10-19(18)23-2)8-13-3-4-20-14(7-13)5-6-24-20/h3-7,9-12H,8H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194451
PNG
(US9200016, 133 | US9902710, Compound 133)
Show SMILES CCCc1ncc(Cc2ccc3c(ccc(OCC(N)=O)c3n2)C(F)(F)F)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H26F3N3O4/c1-4-5-21-19-12-24(36-3)23(35-2)11-18(19)15(13-32-21)10-16-6-7-17-20(27(28,29)30)8-9-22(26(17)33-16)37-14-25(31)34/h6-9,11-13H,4-5,10,14H2,1-3H3,(H2,31,34)
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n/an/a 102n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194319
PNG
(US9200016, 1 | US9902710, Compound 1)
Show SMILES COc1cc2cncc(Cc3ccc4ccccc4c3)c2cc1OC
Show InChI InChI=1S/C22H19NO2/c1-24-21-11-19-14-23-13-18(20(19)12-22(21)25-2)10-15-7-8-16-5-3-4-6-17(16)9-15/h3-9,11-14H,10H2,1-2H3
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n/an/a 105n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194458
PNG
(US9200016, 140 | US9902710, Compound 140)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OC(C)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H26N2O4/c1-5-7-22-21-14-25(31-4)24(30-3)13-20(21)18(15-27-22)12-19-11-10-17-8-6-9-23(26(17)28-19)32-16(2)29/h6,8-11,13-15H,5,7,12H2,1-4H3
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n/an/a 109n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194322
PNG
(US9200016, 4 | US9902710, Compound 4)
Show SMILES COc1cc2cncc(Cc3ccc-4c(Cc5ccccc-45)c3)c2cc1OC
Show InChI InChI=1S/C25H21NO2/c1-27-24-12-20-15-26-14-19(23(20)13-25(24)28-2)10-16-7-8-22-18(9-16)11-17-5-3-4-6-21(17)22/h3-9,12-15H,10-11H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194329
PNG
(US9200016, 11 | US9902710, Compound 11)
Show SMILES COc1cc2cncc(Cc3ccc4N(C)CCc4c3)c2cc1OC
Show InChI InChI=1S/C21H22N2O2/c1-23-7-6-15-8-14(4-5-19(15)23)9-16-12-22-13-17-10-20(24-2)21(25-3)11-18(16)17/h4-5,8,10-13H,6-7,9H2,1-3H3
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n/an/a 132n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194331
PNG
(US9200016, 13 | US9902710, Compound 13)
Show SMILES COc1cc2cncc(Cc3cc4ccccc4nc3N(C)C)c2cc1OC
Show InChI InChI=1S/C23H23N3O2/c1-26(2)23-16(9-15-7-5-6-8-20(15)25-23)10-17-13-24-14-18-11-21(27-3)22(28-4)12-19(17)18/h5-9,11-14H,10H2,1-4H3
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n/an/a 142n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194377
PNG
(US9200016, 59 | US9902710, Compound 59)
Show SMILES COc1cc2c(Cc3ccc4nc(C)ccc4c3)cnc(-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C28H24N2O2/c1-18-9-11-21-13-19(10-12-25(21)30-18)14-22-17-29-28(20-7-5-4-6-8-20)24-16-27(32-3)26(31-2)15-23(22)24/h4-13,15-17H,14H2,1-3H3
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n/an/a 148n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194471
PNG
(US9200016, 153 | US9902710, Compound 153)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(cc3)C#N)c2cc1OC
Show InChI InChI=1S/C26H19N3O3/c1-30-24-11-20-15-28-14-19(21(20)12-25(24)31-2)9-17-5-8-23-22(10-17)29-26(32-23)18-6-3-16(13-27)4-7-18/h3-8,10-12,14-15H,9H2,1-2H3
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n/an/a 148n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194441
PNG
(US9200016, 123 | US9902710, Compound 123)
Show SMILES COc1cc2c(Cc3ccc4cccc(O)c4n3)cnc(C3CC3)c2cc1OC
Show InChI InChI=1S/C24H22N2O3/c1-28-21-11-18-16(10-17-9-8-14-4-3-5-20(27)24(14)26-17)13-25-23(15-6-7-15)19(18)12-22(21)29-2/h3-5,8-9,11-13,15,27H,6-7,10H2,1-2H3
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n/an/a 151n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194372
PNG
(US9200016, 54 | US9902710, Compound 54)
Show SMILES CCCc1ncc(Cc2cc3cc(C)ccc3nc2O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O3/c1-5-6-22-20-13-24(30-4)23(29-3)12-19(20)18(14-26-22)11-17-10-16-9-15(2)7-8-21(16)27-25(17)28/h7-10,12-14H,5-6,11H2,1-4H3,(H,27,28)
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n/an/a 151n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194385
PNG
(US9200016, 67 | US9902710, Compound 67)
Show SMILES CCCCc1ncc(Cc2ccc3nc(C)ccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H28N2O2/c1-5-6-7-24-22-15-26(30-4)25(29-3)14-21(22)20(16-27-24)13-18-9-11-23-19(12-18)10-8-17(2)28-23/h8-12,14-16H,5-7,13H2,1-4H3
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n/an/a 154n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM373575
PNG
(US9902710, Compound 55)
Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2OCC#N)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H27N3O4/c1-5-6-24-22-15-26(33-4)25(32-3)14-21(22)19(16-29-24)12-18-11-17-13-20(31-2)7-8-23(17)30-27(18)34-10-9-28/h7-8,11,13-16H,5-6,10,12H2,1-4H3
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n/an/a 158n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194383
PNG
(US9200016, 65 | US9902710, Compound 65)
Show SMILES CCCc1ncc(Cc2cc3ccccc3cn2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O2/c1-4-7-22-21-13-24(28-3)23(27-2)12-20(21)18(15-26-22)11-19-10-16-8-5-6-9-17(16)14-25-19/h5-6,8-10,12-15H,4,7,11H2,1-3H3
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n/an/a 159n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194346
PNG
(US9200016, 28 | US9902710, Compound 28)
Show SMILES CCOc1cc2cncc(Cc3cnc4ccccc4c3)c2cc1OCC
Show InChI InChI=1S/C23H22N2O2/c1-3-26-22-11-19-15-24-14-18(20(19)12-23(22)27-4-2)10-16-9-17-7-5-6-8-21(17)25-13-16/h5-9,11-15H,3-4,10H2,1-2H3
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n/an/a 168n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194351
PNG
(US9200016, 33 | US9902710, Compound 33)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4oc5ccccc5c4c3)c2cc1OC
Show InChI InChI=1S/C25H21NO3/c1-15-19-12-24(27-2)25(28-3)13-20(19)17(14-26-15)10-16-8-9-23-21(11-16)18-6-4-5-7-22(18)29-23/h4-9,11-14H,10H2,1-3H3
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n/an/a 184n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194432
PNG
(US9200016, 114 | US9902710, Compound 114)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C25H20N2O3/c1-28-23-12-19-15-26-14-18(20(19)13-24(23)29-2)10-16-8-9-22-21(11-16)27-25(30-22)17-6-4-3-5-7-17/h3-9,11-15H,10H2,1-2H3
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n/an/a 189n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM373659
PNG
(US9902710, Compound 135)
Show SMILES CCc1ncc(Cc2ccc3cccc(OCCN)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H27N3O3/c1-4-21-20-14-24(30-3)23(29-2)13-19(20)17(15-27-21)12-18-9-8-16-6-5-7-22(25(16)28-18)31-11-10-26/h5-9,13-15H,4,10-12,26H2,1-3H3
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n/an/a 192n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194343
PNG
(US9200016, 25 | US9902710, Compound 25)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4ccccc4c3)c2cc1OC
Show InChI InChI=1S/C23H21NO2/c1-15-20-12-22(25-2)23(26-3)13-21(20)19(14-24-15)11-16-8-9-17-6-4-5-7-18(17)10-16/h4-10,12-14H,11H2,1-3H3
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n/an/a 194n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194476
PNG
(US9200016, 158 | US9902710, Compound 158)
Show SMILES CCCc1ncc(Cc2ccc3cccc(NC(=O)COC(C)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H29N3O5/c1-5-7-23-22-14-26(35-4)25(34-3)13-21(22)19(15-29-23)12-20-11-10-18-8-6-9-24(28(18)30-20)31-27(33)16-36-17(2)32/h6,8-11,13-15H,5,7,12,16H2,1-4H3,(H,31,33)
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n/an/a 204n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194323
PNG
(US9200016, 5 | US9902710, Compound 5)
Show SMILES COc1cc2cncc(Cc3ccc4ccccc4n3)c2cc1OC
Show InChI InChI=1S/C21H18N2O2/c1-24-20-10-16-13-22-12-15(18(16)11-21(20)25-2)9-17-8-7-14-5-3-4-6-19(14)23-17/h3-8,10-13H,9H2,1-2H3
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n/an/a 208n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194341
PNG
(US9200016, 23 | US9902710, Compound 23)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(OCc5ccncc5)c4n3)c2cc1OC
Show InChI InChI=1S/C27H23N3O3/c1-31-25-13-21-16-29-15-20(23(21)14-26(25)32-2)12-22-7-6-19-4-3-5-24(27(19)30-22)33-17-18-8-10-28-11-9-18/h3-11,13-16H,12,17H2,1-2H3
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n/an/a 213n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194336
PNG
(US9200016, 18 | US9902710, Compound 18)
Show SMILES CCn1ncc2c(O)c(Cc3cncc4cc(OC)c(OC)cc34)cnc12
Show InChI InChI=1S/C20H20N4O3/c1-4-24-20-16(11-23-24)19(25)14(10-22-20)5-12-8-21-9-13-6-17(26-2)18(27-3)7-15(12)13/h6-11H,4-5H2,1-3H3,(H,22,25)
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n/an/a 238n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194358
PNG
(US9200016, 40 | US9902710, Compound 40)
Show SMILES CCCc1ncc(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H25NO3/c1-4-7-23-21-15-27(30-3)26(29-2)14-20(21)18(16-28-23)12-17-10-11-25-22(13-17)19-8-5-6-9-24(19)31-25/h5-6,8-11,13-16H,4,7,12H2,1-3H3
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n/an/a 278n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194355
PNG
(US9200016, 37 | US9902710, Compound 37)
Show SMILES CCOc1cc2c(Cc3ccc4oc5ccccc5c4c3)cncc2cc1OC
Show InChI InChI=1S/C25H21NO3/c1-3-28-25-13-20-17(14-26-15-18(20)12-24(25)27-2)10-16-8-9-23-21(11-16)19-6-4-5-7-22(19)29-23/h4-9,11-15H,3,10H2,1-2H3
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n/an/a 287n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194350
PNG
(US9200016, 32 | US9902710, Compound 32)
Show SMILES CCCOc1cccc2ccc(Cc3cncc4cc(OC)c(OC)cc34)nc12
Show InChI InChI=1S/C24H24N2O3/c1-4-10-29-21-7-5-6-16-8-9-19(26-24(16)21)11-17-14-25-15-18-12-22(27-2)23(28-3)13-20(17)18/h5-9,12-15H,4,10-11H2,1-3H3
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n/an/a 315n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194334
PNG
(US9200016, 16 | US9902710, Compound 16)
Show SMILES CCn1ncc2c(Cl)c(Cc3cncc4cc(OC)c(OC)cc34)cnc12
Show InChI InChI=1S/C20H19ClN4O2/c1-4-25-20-16(11-24-25)19(21)14(10-23-20)5-12-8-22-9-13-6-17(26-2)18(27-3)7-15(12)13/h6-11H,4-5H2,1-3H3
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n/an/a 330n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194357
PNG
(US9200016, 39 | US9902710, Compound 39)
Show SMILES CCc1ncc(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H23NO3/c1-4-22-20-14-26(29-3)25(28-2)13-19(20)17(15-27-22)11-16-9-10-24-21(12-16)18-7-5-6-8-23(18)30-24/h5-10,12-15H,4,11H2,1-3H3
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n/an/a 339n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194378
PNG
(US9200016, 60 | US9902710, Compound 60)
Show SMILES COc1cc2c(Cc3ccc4nc(C)ccc4c3)cnc(C3CCCCC3)c2cc1OC
Show InChI InChI=1S/C28H30N2O2/c1-18-9-11-21-13-19(10-12-25(21)30-18)14-22-17-29-28(20-7-5-4-6-8-20)24-16-27(32-3)26(31-2)15-23(22)24/h9-13,15-17,20H,4-8,14H2,1-3H3
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n/an/a 368n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194450
PNG
(US9200016, 132 | US9902710, Compound 132)
Show SMILES CCCc1ncc(Cc2ccc3c(ccc(O)c3n2)C(F)(F)F)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H23F3N2O3/c1-4-5-20-18-12-23(33-3)22(32-2)11-17(18)14(13-29-20)10-15-6-7-16-19(25(26,27)28)8-9-21(31)24(16)30-15/h6-9,11-13,31H,4-5,10H2,1-3H3
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n/an/a 491n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194410
PNG
(US9200016, 92 | US9902710, Compound 92)
Show SMILES CCOC(=O)C(=O)Nc1cccc2ccc(Cc3cnc(CC)c4cc(OC)c(OC)cc34)nc12
Show InChI InChI=1S/C27H27N3O5/c1-5-21-20-14-24(34-4)23(33-3)13-19(20)17(15-28-21)12-18-11-10-16-8-7-9-22(25(16)29-18)30-26(31)27(32)35-6-2/h7-11,13-15H,5-6,12H2,1-4H3,(H,30,31)
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n/an/a 495n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194388
PNG
(US9200016, 70 | US9902710, Compound 70)
Show SMILES CCCCc1ncc(Cc2cnc3cc(C)ccc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H28N2O2/c1-5-6-7-23-22-14-26(30-4)25(29-3)13-21(22)20(16-28-23)12-18-11-19-9-8-17(2)10-24(19)27-15-18/h8-11,13-16H,5-7,12H2,1-4H3
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n/an/a 946n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194340
PNG
(US9200016, 22 | US9902710, Compound 22)
Show SMILES COc1cc2cnc(C)c(Cc3ccc4ccccc4c3)c2cc1OC
Show InChI InChI=1S/C23H21NO2/c1-15-20(11-16-8-9-17-6-4-5-7-18(17)10-16)21-13-23(26-3)22(25-2)12-19(21)14-24-15/h4-10,12-14H,11H2,1-3H3
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n/an/a 1.07E+3n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194459
PNG
(US9200016, 141 | US9902710, Compound 141)
Show SMILES CCc1ncc(Cc2ccc3cccc(OC(C)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H24N2O4/c1-5-21-20-13-24(30-4)23(29-3)12-19(20)17(14-26-21)11-18-10-9-16-7-6-8-22(25(16)27-18)31-15(2)28/h6-10,12-14H,5,11H2,1-4H3
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n/an/a 3.11E+3n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194356
PNG
(US9200016, 38 | US9902710, Compound 38)
Show SMILES C(c1ccc2oc3ccccc3c2c1)c1cncc2cc3OCOc3cc12
Show InChI InChI=1S/C23H15NO3/c1-2-4-20-17(3-1)19-8-14(5-6-21(19)27-20)7-15-11-24-12-16-9-22-23(10-18(15)16)26-13-25-22/h1-6,8-12H,7,13H2
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US Patent
n/an/a 3.17E+3n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194335
PNG
(US9200016, 17 | US9902710, Compound 17)
Show SMILES CCOc1c(Cc2cncc3cc(OC)c(OC)cc23)cnc2n(CC)ncc12
Show InChI InChI=1S/C22H24N4O3/c1-5-26-22-18(13-25-26)21(29-6-2)16(12-24-22)7-14-10-23-11-15-8-19(27-3)20(28-4)9-17(14)15/h8-13H,5-7H2,1-4H3
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n/an/a 3.56E+3n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194354
PNG
(US9200016, 36 | US9902710, Compound 36)
Show SMILES C(c1ccc2oc3ccccc3c2c1)c1cncc2cc3OCCOc3cc12
Show InChI InChI=1S/C24H17NO3/c1-2-4-21-18(3-1)20-10-15(5-6-22(20)28-21)9-16-13-25-14-17-11-23-24(12-19(16)17)27-8-7-26-23/h1-6,10-14H,7-9H2
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n/an/a 7.56E+3n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194347
PNG
(US9200016, 29 | US9902710, Compound 29)
Show SMILES COc1cc2cncc(Cc3cnc4ccccc4c3)c2cc1O
Show InChI InChI=1S/C20H16N2O2/c1-24-20-8-16-12-21-11-15(17(16)9-19(20)23)7-13-6-14-4-2-3-5-18(14)22-10-13/h2-6,8-12,23H,7H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194389
PNG
(US9200016, 71 | US9902710, Compound 71)
Show SMILES COc1cc2c(Cc3cnc4ccccc4c3)cnc(C3CCCCC3)c2cc1OC
Show InChI InChI=1S/C27H28N2O2/c1-30-25-14-22-21(13-18-12-20-10-6-7-11-24(20)28-16-18)17-29-27(19-8-4-3-5-9-19)23(22)15-26(25)31-2/h6-7,10-12,14-17,19H,3-5,8-9,13H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM194348
PNG
(US9200016, 30 | US9902710, Compound 30)
Show SMILES COc1cc2c(Cc3cnc4ccccc4c3)cncc2cc1O
Show InChI InChI=1S/C20H16N2O2/c1-24-20-9-17-15(11-21-12-16(17)8-19(20)23)7-13-6-14-4-2-3-5-18(14)22-10-13/h2-6,8-12,23H,7H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



EXONHIT THERAPEUTICS, SA; ALLERGAN, INC.

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...


US Patent US9902710 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%