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Found 169 Enz. Inhib. hit(s) with all data for entry = 2625
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194437(US9200016, 119 | US9902710, Compound 119)
Affinity DataIC50:  0.180nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194477(US9200016, 159 | US9902710, Compound 159)
Affinity DataIC50:  0.420nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194402(US9200016, 84 | US9902710, Compound 84)
Affinity DataIC50:  0.530nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194474(US9200016, 156 | US9902710, Compound 156)
Affinity DataIC50:  0.710nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194403(US9200016, 85 | US9902710, Compound 85)
Affinity DataIC50:  0.820nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194392(US9200016, 74 | US9902710, Compound 74)
Affinity DataIC50:  1.20nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194391(US9200016, 139 | US9200016, 73 | US9902710, Compou...)
Affinity DataIC50:  1.40nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194463(US9200016, 145 | US9902710, Compound 145)
Affinity DataIC50:  1.60nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194436(US9200016, 118 | US9902710, Compound 118)
Affinity DataIC50:  2.30nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194456(US9200016, 138 | US9902710, Compound 138)
Affinity DataIC50:  2.5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194455(US9200016, 137 | US9902710, Compound 137)
Affinity DataIC50:  2.90nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194407(US9200016, 89 | US9902710, Compound 89)
Affinity DataIC50:  3.5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194416(US9200016, 98 | US9902710, Compound 98)
Affinity DataIC50:  3.5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194399(US9200016, 81 | US9902710, Compound 81)
Affinity DataIC50:  3.60nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194423(US9200016, 105 | US9902710, Compound 105)
Affinity DataIC50:  4.30nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194400(US9200016, 82 | US9902710, Compound 82)
Affinity DataIC50:  4.40nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194487(US9200016, 169 | US9902710, Compound 169)
Affinity DataIC50:  4.5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194418(US9200016, 100 | US9902710, Compound 100)
Affinity DataIC50:  4.60nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194439(US9200016, 121 | US9902710, Compound 121)
Affinity DataIC50:  4.70nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194464(US9200016, 146 | US9902710, Compound 146)
Affinity DataIC50:  4.70nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194426(US9200016, 108 | US9902710, Compound 108)
Affinity DataIC50:  4.90nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194440(US9200016, 122 | US9902710, Compound 122)
Affinity DataIC50:  5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194397(US9200016, 79 | US9902710, Compound 79)
Affinity DataIC50:  5.10nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194387(US9200016, 69 | US9902710, Compound 69)
Affinity DataIC50:  5.20nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194391(US9200016, 139 | US9200016, 73 | US9902710, Compou...)
Affinity DataIC50:  5.30nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194486(US9200016, 168 | US9902710, Compound 168)
Affinity DataIC50:  5.60nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194479(US9200016, 161 | US9902710, Compound 161)
Affinity DataIC50:  6nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM373566(US9902710, Compound 48)
Affinity DataIC50:  6.5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194462(US9200016, 144 | US9902710, Compound 144)
Affinity DataIC50:  6.5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194393(US9200016, 75 | US9902710, Compound 75)
Affinity DataIC50:  6.60nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194435(US9200016, 117 | US9902710, Compound 117)
Affinity DataIC50:  7.10nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194328(US9200016, 10 | US9902710, Compound 10)
Affinity DataIC50:  7.60nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194425(US9200016, 107 | US9902710, Compound 107)
Affinity DataIC50:  7.80nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194468(US9200016, 150 | US9902710, Compound 150)
Affinity DataIC50:  7.90nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194404(US9200016, 86 | US9902710, Compound 86)
Affinity DataIC50:  8.30nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194485(US9200016, 167 | US9902710, Compound 167)
Affinity DataIC50:  8.60nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194461(US9200016, 143 | US9902710, Compound 143)
Affinity DataIC50:  9.40nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194447(US9200016, 129 | US9902710, Compound 129)
Affinity DataIC50:  9.5nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194395(US9200016, 77 | US9902710, Compound 77)
Affinity DataIC50:  9.70nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194362(US9200016, 44 | US9902710, Compound 44)
Affinity DataIC50:  11nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194401(US9200016, 83 | US9902710, Compound 83)
Affinity DataIC50:  11nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194394(US9200016, 106 | US9200016, 76 | US9902710, Compou...)
Affinity DataIC50:  11nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194470(US9200016, 152 | US9902710, Compound 152)
Affinity DataIC50:  13nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194475(US9200016, 157 | US9902710, Compound 157)
Affinity DataIC50:  13nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194414(US9200016, 96 | US9902710, Compound 96)
Affinity DataIC50:  13nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194320(US9200016, 2 | US9902710, Compound 2)
Affinity DataIC50:  13nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194412(US9200016, 94 | US9902710, Compound 94)
Affinity DataIC50:  13nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194480(US9200016, 162 | US9902710, Compound 162)
Affinity DataIC50:  13nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM194415(US9200016, 97 | US9902710, Compound 97)
Affinity DataIC50:  15nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Exonhit Therapeutics

US Patent
LigandPNGBDBM373685(US9902710, Compound 160)
Affinity DataIC50:  15nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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