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Patent code US9902714

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM373519
PNG
(US9902714, Compound 2)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cn[nH]c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32-3)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)29-23(14-26-21)17-12-27-28-13-17/h5-6,9-14,16H,7-8,15H2,1-4H3,(H,27,28)
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n/an/an/a 741n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM373522
PNG
(US9902714, Compound 4)
Show SMILES COc1cc(O)cc2N(CCN(Cc12)C(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a 740n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM373520
PNG
(US9902714, Compound 3)
Show SMILES COc1cc(O)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(33-4)11-25(32)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a 1.90E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM373523
PNG
(US9902714, Compound 6)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(C)Cc2c(OC)cc(OC)cc12
Show InChI InChI=1S/C25H28N6O2/c1-5-30-15-17(13-27-30)23-14-26-21-7-6-18(10-22(21)28-23)31-9-8-29(2)16-20-24(31)11-19(32-3)12-25(20)33-4/h6-7,10-15H,5,8-9,16H2,1-4H3
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n/an/an/a 2.20E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM373525
PNG
(US9902714, Compound 7)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(Cc2c(OC)cc(OC)cc12)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-6-32-16-19(14-29-32)25-15-28-23-8-7-20(11-24(23)30-25)33-10-9-31(18(2)3)17-22-26(33)12-21(34-4)13-27(22)35-5/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 170n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM373274
PNG
(US9902714, Compound 1)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C26H30N6O2/c1-17(2)31-8-9-32(25-11-20(33-4)12-26(34-5)21(25)16-31)19-6-7-22-23(10-19)29-24(14-27-22)18-13-28-30(3)15-18/h6-7,10-15,17H,8-9,16H2,1-5H3
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n/an/an/a 314n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM373274
PNG
(US9902714, Compound 1)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C26H30N6O2/c1-17(2)31-8-9-32(25-11-20(33-4)12-26(34-5)21(25)16-31)19-6-7-22-23(10-19)29-24(14-27-22)18-13-28-30(3)15-18/h6-7,10-15,17H,8-9,16H2,1-5H3
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n/an/an/a>3.01E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM373519
PNG
(US9902714, Compound 2)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cn[nH]c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32-3)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)29-23(14-26-21)17-12-27-28-13-17/h5-6,9-14,16H,7-8,15H2,1-4H3,(H,27,28)
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n/an/an/a 68n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM373523
PNG
(US9902714, Compound 6)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(C)Cc2c(OC)cc(OC)cc12
Show InChI InChI=1S/C25H28N6O2/c1-5-30-15-17(13-27-30)23-14-26-21-7-6-18(10-22(21)28-23)31-9-8-29(2)16-20-24(31)11-19(32-3)12-25(20)33-4/h6-7,10-15H,5,8-9,16H2,1-4H3
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n/an/an/a 2.40E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM373526
PNG
(US9902714, Compound 9)
Show SMILES COc1cc(OC)c2CN(CCCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-18(2)32-9-6-10-33(26-12-21(34-4)13-27(35-5)22(26)17-32)20-7-8-23-24(11-20)30-25(15-28-23)19-14-29-31(3)16-19/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 54n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM373522
PNG
(US9902714, Compound 4)
Show SMILES COc1cc(O)cc2N(CCN(Cc12)C(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a 900n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM373523
PNG
(US9902714, Compound 6)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(C)Cc2c(OC)cc(OC)cc12
Show InChI InChI=1S/C25H28N6O2/c1-5-30-15-17(13-27-30)23-14-26-21-7-6-18(10-22(21)28-23)31-9-8-29(2)16-20-24(31)11-19(32-3)12-25(20)33-4/h6-7,10-15H,5,8-9,16H2,1-4H3
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n/an/an/a 2.90E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM373523
PNG
(US9902714, Compound 6)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(C)Cc2c(OC)cc(OC)cc12
Show InChI InChI=1S/C25H28N6O2/c1-5-30-15-17(13-27-30)23-14-26-21-7-6-18(10-22(21)28-23)31-9-8-29(2)16-20-24(31)11-19(32-3)12-25(20)33-4/h6-7,10-15H,5,8-9,16H2,1-4H3
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n/an/an/a>3.00E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM373526
PNG
(US9902714, Compound 9)
Show SMILES COc1cc(OC)c2CN(CCCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-18(2)32-9-6-10-33(26-12-21(34-4)13-27(35-5)22(26)17-32)20-7-8-23-24(11-20)30-25(15-28-23)19-14-29-31(3)16-19/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 117n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM373519
PNG
(US9902714, Compound 2)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cn[nH]c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32-3)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)29-23(14-26-21)17-12-27-28-13-17/h5-6,9-14,16H,7-8,15H2,1-4H3,(H,27,28)
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n/an/an/a 63n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM373525
PNG
(US9902714, Compound 7)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(Cc2c(OC)cc(OC)cc12)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-6-32-16-19(14-29-32)25-15-28-23-8-7-20(11-24(23)30-25)33-10-9-31(18(2)3)17-22-26(33)12-21(34-4)13-27(22)35-5/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 79n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM373526
PNG
(US9902714, Compound 9)
Show SMILES COc1cc(OC)c2CN(CCCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-18(2)32-9-6-10-33(26-12-21(34-4)13-27(35-5)22(26)17-32)20-7-8-23-24(11-20)30-25(15-28-23)19-14-29-31(3)16-19/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 138n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM373525
PNG
(US9902714, Compound 7)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(Cc2c(OC)cc(OC)cc12)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-6-32-16-19(14-29-32)25-15-28-23-8-7-20(11-24(23)30-25)33-10-9-31(18(2)3)17-22-26(33)12-21(34-4)13-27(22)35-5/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 340n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM373526
PNG
(US9902714, Compound 9)
Show SMILES COc1cc(OC)c2CN(CCCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-18(2)32-9-6-10-33(26-12-21(34-4)13-27(35-5)22(26)17-32)20-7-8-23-24(11-20)30-25(15-28-23)19-14-29-31(3)16-19/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 922n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM373274
PNG
(US9902714, Compound 1)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C26H30N6O2/c1-17(2)31-8-9-32(25-11-20(33-4)12-26(34-5)21(25)16-31)19-6-7-22-23(10-19)29-24(14-27-22)18-13-28-30(3)15-18/h6-7,10-15,17H,8-9,16H2,1-5H3
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n/an/an/a 674n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM373519
PNG
(US9902714, Compound 2)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cn[nH]c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32-3)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)29-23(14-26-21)17-12-27-28-13-17/h5-6,9-14,16H,7-8,15H2,1-4H3,(H,27,28)
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n/an/an/a 68n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM373520
PNG
(US9902714, Compound 3)
Show SMILES COc1cc(O)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(33-4)11-25(32)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a 720n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM373522
PNG
(US9902714, Compound 4)
Show SMILES COc1cc(O)cc2N(CCN(Cc12)C(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a>3.00E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM373525
PNG
(US9902714, Compound 7)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(Cc2c(OC)cc(OC)cc12)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-6-32-16-19(14-29-32)25-15-28-23-8-7-20(11-24(23)30-25)33-10-9-31(18(2)3)17-22-26(33)12-21(34-4)13-27(22)35-5/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 1.70E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM373522
PNG
(US9902714, Compound 4)
Show SMILES COc1cc(O)cc2N(CCN(Cc12)C(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a 870n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM373522
PNG
(US9902714, Compound 4)
Show SMILES COc1cc(O)cc2N(CCN(Cc12)C(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a>3.00E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM373523
PNG
(US9902714, Compound 6)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(C)Cc2c(OC)cc(OC)cc12
Show InChI InChI=1S/C25H28N6O2/c1-5-30-15-17(13-27-30)23-14-26-21-7-6-18(10-22(21)28-23)31-9-8-29(2)16-20-24(31)11-19(32-3)12-25(20)33-4/h6-7,10-15H,5,8-9,16H2,1-4H3
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n/an/an/a>3.00E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM373525
PNG
(US9902714, Compound 7)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(cc2n1)N1CCN(Cc2c(OC)cc(OC)cc12)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-6-32-16-19(14-29-32)25-15-28-23-8-7-20(11-24(23)30-25)33-10-9-31(18(2)3)17-22-26(33)12-21(34-4)13-27(22)35-5/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 230n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM373526
PNG
(US9902714, Compound 9)
Show SMILES COc1cc(OC)c2CN(CCCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C27H32N6O2/c1-18(2)32-9-6-10-33(26-12-21(34-4)13-27(35-5)22(26)17-32)20-7-8-23-24(11-20)30-25(15-28-23)19-14-29-31(3)16-19/h7-8,11-16,18H,6,9-10,17H2,1-5H3
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n/an/an/a 355n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM373274
PNG
(US9902714, Compound 1)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C26H30N6O2/c1-17(2)31-8-9-32(25-11-20(33-4)12-26(34-5)21(25)16-31)19-6-7-22-23(10-19)29-24(14-27-22)18-13-28-30(3)15-18/h6-7,10-15,17H,8-9,16H2,1-5H3
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n/an/an/a 325n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM373274
PNG
(US9902714, Compound 1)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C26H30N6O2/c1-17(2)31-8-9-32(25-11-20(33-4)12-26(34-5)21(25)16-31)19-6-7-22-23(10-19)29-24(14-27-22)18-13-28-30(3)15-18/h6-7,10-15,17H,8-9,16H2,1-5H3
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n/an/an/a 778n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM373519
PNG
(US9902714, Compound 2)
Show SMILES COc1cc(OC)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cn[nH]c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(32-3)11-25(33-4)20(24)15-30)18-5-6-21-22(9-18)29-23(14-26-21)17-12-27-28-13-17/h5-6,9-14,16H,7-8,15H2,1-4H3,(H,27,28)
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n/an/an/a 17n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM373520
PNG
(US9902714, Compound 3)
Show SMILES COc1cc(O)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(33-4)11-25(32)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a 300n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM373520
PNG
(US9902714, Compound 3)
Show SMILES COc1cc(O)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(33-4)11-25(32)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a>3.00E+3n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM373520
PNG
(US9902714, Compound 3)
Show SMILES COc1cc(O)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
Show InChI InChI=1S/C25H28N6O2/c1-16(2)30-7-8-31(24-10-19(33-4)11-25(32)20(24)15-30)18-5-6-21-22(9-18)28-23(13-26-21)17-12-27-29(3)14-17/h5-6,9-14,16,32H,7-8,15H2,1-4H3
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n/an/an/a 620n/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....


US Patent US9902714 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%