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Patent code US9907800

Compile Data Set for Download or QSAR

Found 460 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375433
PNG
(US9907800, Example A145)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)C#Cc3ccc(CN4CCN(C)CC4)cc3)c2c1
PDB
MMDB

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US Patent


Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375434
PNG
(US10358436, Example A146 | US9907800, Example A146)
Show SMILES CCN(CC)Cc1c(F)cc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccc(OC)cc23)cc1F
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044670
PNG
(CHEMBL3353359 | US10358436, Example A147 | US99078...)
Show SMILES CN1CCN(Cc2ccc(\C=C\c3n[nH]c4cc(ccc34)[C@@H]3C[C@@]33C(=O)Nc4ccccc34)cc2)CC1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375449
PNG
(US10358436, Example A159 | US9907800, Example A159)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(CCN4CCOCC4)cc3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375454
PNG
(US10358436, Example A164 | US9907800, Example A164)
Show SMILES CN(C)Cc1cccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)N(CC(N)=O)c3ccccc23)c1
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM375461
PNG
(US10358436, Example A171 | US9907800, Example A171)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(Cl)cc23)cc1
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Assay Description
Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375464
PNG
(US10358436, Example A173 | US9907800, Example A173)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C1C[C@@]11C(=O)Nc2ccc(C)cc12
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375469
PNG
(US9907800, Example A178)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375470
PNG
(US9907800, Example A179)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(cc5)C(=O)N5CCN(C)CC5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375471
PNG
(US9907800, Example A180)
Show SMILES COCCN1C(=O)[C@@]2(CC2c2ccc3c(\C=C\c4ccc(CN(C)C)cc4)n[nH]c3c2)c2ccccc12
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375471
PNG
(US9907800, Example A180)
Show SMILES COCCN1C(=O)[C@@]2(CC2c2ccc3c(\C=C\c4ccc(CN(C)C)cc4)n[nH]c3c2)c2ccccc12
PDB

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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375472
PNG
(US9907800, Example A181)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5csc(CN(C)C)c5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375479
PNG
(US9907800, Example A188)
Show SMILES CCN1CCN(CC1)c1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(OC)cc23)cc1
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375483
PNG
(US10358436, Example A192 | US9907800, Example A192)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCN(CC3)C3CCCC3)c2c1
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044668
PNG
(CHEMBL3353357 | US10358436, Example A195 | US99078...)
Show SMILES Cc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCOCC6)cc5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375488
PNG
(US10358436, Example A197 | US9907800, Example A197)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccnc5)n[nH]c4c3)c2c1
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375494
PNG
(US10358436, Example A203 | US9907800, Example A203)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6[C@@H](C)CCC[C@H]6C)cc5)n[nH]c4c3)c2c1
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375504
PNG
(US9907800, Example A213)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(nc5)N5CCOCC5)n[nH]c4c3)c2c1
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044651
PNG
(CHEMBL3353349 | US10358436, Example A214 | US99078...)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccc(OC(F)F)cc23)cc1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375507
PNG
(US10358436, Example A216 | US9907800, Example A216)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN(C)C)c(F)c5)n[nH]c4c3)c2c1
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375508
PNG
(US9907800, Example A217)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5cc(F)c(CN6CCOCC6)c(F)c5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM375291
PNG
(US10358436, Example A16 | US9907800, Example A16)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCN(C)CC3)c2c1
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Assay Description
The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM375466
PNG
(US10358436, Example A175 | US9907800, Example A175)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(cc5)N5CCN(C)CC5)n[nH]c4c3)c2c1
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Assay Description
The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375290
PNG
(US10358436, Example A15 | US9907800, Example A15)
Show SMILES COc1ccc2NC(=O)[C@]3(C[C@@H]3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCN(C)CC3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375291
PNG
(US10358436, Example A16 | US9907800, Example A16)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCN(C)CC3)c2c1
PDB

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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375295
PNG
(US9907800, Example A20)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCOCC3)c2c1
PDB

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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375297
PNG
(US9907800, Example A22)
Show SMILES O=C1Nc2ccccc2[C@]11CC1c1ccc2c(\C=C\c3ccncc3)n[nH]c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044660
PNG
(CHEMBL3353342 | US10358436, Example A29 | US990780...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3cccnc3)n[nH]c2c1
PDB

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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375311
PNG
(US10358436, Example A32 | US9907800, Example A32)
Show SMILES COc1ccc2NC(=O)[C@]3(C[C@@H]3c3ccc4c(\C=C\c5ccc(nc5)N5CCN(C)CC5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044665
PNG
(CHEMBL3353341 | US10358436, Example A33 | US990780...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(nc5)N5CCN(C)CC5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044656
PNG
(CHEMBL3353348 | US10358436, Example A35 | US990780...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044656
PNG
(CHEMBL3353348 | US10358436, Example A35 | US990780...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1
PDB

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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044674
PNG
(CHEMBL3353355 | US10358436, Example A42 | US990780...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCOCC6)cc5)n[nH]c4c3)c2c1
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375326
PNG
(US10358436, Example A46 | US9907800, Example A46)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3cccc(CCO)c3)c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375327
PNG
(US10358436, Example A47 | US9907800, Example A47)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3cccc(c3)N3CCNCC3)c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375333
PNG
(US10358436, Example A53 | US9907800, Example A53)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccccn3)n[nH]c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375333
PNG
(US10358436, Example A53 | US9907800, Example A53)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccccn3)n[nH]c2c1
PDB

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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044675
PNG
(CHEMBL3353354 | US10358436, Example A56 | US990780...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCOCC4)cc3)n[nH]c2c1
PDB

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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044675
PNG
(CHEMBL3353354 | US10358436, Example A56 | US990780...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCOCC4)cc3)n[nH]c2c1
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US Patent


Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044662
PNG
(CHEMBL3353361 | US10358436, Example A61 | US990780...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCCC4)cc3)n[nH]c2c1
PDB

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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375347
PNG
(US10358436, Example A67 | US9907800, Example A67)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(OCCN4CCCCC4)cc3)c2c1
PDB

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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375352
PNG
(US10358436, Example A71 | US9907800, Example A71)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc4CCNCc4c3)c2c1
PDB

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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375354
PNG
(US10358436, Example A73 | US9907800, Example A73)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCCOCC6)cc5)n[nH]c4c3)c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375354
PNG
(US10358436, Example A73 | US9907800, Example A73)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCCOCC6)cc5)n[nH]c4c3)c2c1
PDB

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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375355
PNG
(US10358436, Example A74 | US9907800, Example A74)
Show SMILES CN1CCc2cc(\C=C\c3n[nH]c4cc(ccc34)[C@@H]3C[C@@]33C(=O)Nc4ccccc34)ccc2C1
PDB

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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375357
PNG
(US10358436, Example A76 | US9907800, Example A76)
Show SMILES CN1CCc2cc(ccc2C1)-c1n[nH]c2cc(ccc12)[C@@H]1C[C@@]11C(=O)Nc2ccccc12
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375360
PNG
(US10358436, Example A79 | US9907800, Example A79)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(OC6CCN(C)CC6)cc5)n[nH]c4c3)c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375363
PNG
(US10358436, Example A82 | US9907800, Example A82)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CC6CCN(C)CC6)cc5)n[nH]c4c3)c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375365
PNG
(US9907800, Example A84)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375366
PNG
(US9907800, Example A85)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@@H]3c3ccc4c(\C=C\c5ccc(nc5)N5CCN(C)CC5)n[nH]c4c3)c2c1
PDB
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Assay Description
PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...


US Patent US9907800 (2018)


BindingDB Entry DOI: 10.7270/Q2KD216W
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 460 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%