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Patent code US9908845

Compile Data Set for Download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372991
PNG
(US9896418, Compound 63)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)CF
Show InChI InChI=1/C17H11F4NO4S/c18-8-27(24,25)14-2-1-13(12-6-17(20,21)16(23)15(12)14)26-11-4-9(7-22)3-10(19)5-11/h1-5,16,23H,6,8H2/t16-/s2
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n/an/an/an/a 20n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372992
PNG
(US9896418, Compound 64)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)CF
Show InChI InChI=1/C16H11F5O4S/c17-7-26(23,24)13-2-1-12(11-6-16(20,21)15(22)14(11)13)25-10-4-8(18)3-9(19)5-10/h1-5,15,22H,6-7H2/t15-/s2
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n/an/an/an/a 1n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372999
PNG
(US9896418, Compound 102)
Show SMILES OCc1c(Br)c(Oc2cc(F)cc(Cl)c2)ccc1S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C14H8BrClF4O4S/c15-13-10(6-21)12(25(22,23)14(18,19)20)2-1-11(13)24-9-4-7(16)3-8(17)5-9/h1-5,21H,6H2
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n/an/an/an/a 640n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373001
PNG
(US9896418, Compound 132)
Show SMILES FC(F)S(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c(Br)c1
Show InChI InChI=1S/C14H7BrF3NO3S/c15-12-6-11(23(20,21)14(17)18)1-2-13(12)22-10-4-8(7-19)3-9(16)5-10/h1-6,14H
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n/an/an/an/a 680n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373005
PNG
(US9896418, Compound 159)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)C(O)c12
Show InChI InChI=1/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3
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n/an/an/an/a 7n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373006
PNG
(US9896418, Compound 161)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/s2
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n/an/an/an/a 11n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373019
PNG
(US9896418, Compound 191)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)C(O)c12
Show InChI InChI=1/C17H12F4N2O3S/c1-27(25,23-8-22)14-3-2-13(12-7-17(20,21)16(24)15(12)14)26-11-5-9(18)4-10(19)6-11/h2-6,16,24H,7H2,1H3
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n/an/an/an/a 130n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373039
PNG
(US9896418, Compound 274)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=N)(=O)CF
Show InChI InChI=1/C17H12F4N2O3S/c18-8-27(23,25)14-2-1-13(12-6-17(20,21)16(24)15(12)14)26-11-4-9(7-22)3-10(19)5-11/h1-5,16,23-24H,6,8H2/t16-,27?/s2
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n/an/an/an/a 1.44E+3n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373044
PNG
(US9896418, Compound 305 | US9896418, Compound 306)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=N)(=O)C(F)(F)F
Show InChI InChI=1/C17H10F6N2O3S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(25,27)17(21,22)23)14-11(12)6-16(19,20)15(14)26/h1-5,15,25-26H,6H2/t15-,29?/s2
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n/an/an/an/a 19.2n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373046
PNG
(US9896418, Compound 303)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(c1)C#N)ccc2C(F)(F)F
Show InChI InChI=1/C16H9F5N2O2/c17-15(18)4-10-12(25-9-3-8(5-22)6-23-7-9)2-1-11(16(19,20)21)13(10)14(15)24/h1-3,6-7,14,24H,4H2/t14-/s2
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n/an/an/an/a 64n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372986
PNG
(US9896418, Compound 25)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(Cl)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C15H10ClF4NO4S/c16-7-3-8(6-21-5-7)25-10-1-2-11(26(23,24)14(17)18)12-9(10)4-15(19,20)13(12)22/h1-3,5-6,13-14,22H,4H2/t13-/s2
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n/an/an/an/a 37n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373002
PNG
(US9896418, Compound 133)
Show SMILES FC(F)S(=O)(=O)c1ccc(Oc2cc(F)cc(Cl)c2)c(c1)C#N
Show InChI InChI=1S/C14H7ClF3NO3S/c15-9-4-10(16)6-11(5-9)22-13-2-1-12(3-8(13)7-19)23(20,21)14(17)18/h1-6,14H
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n/an/an/an/a 1.87E+3n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373016
PNG
(US9896418, Compound 186)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(Cl)c1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C15H9ClF5NO4S/c16-7-3-8(6-22-5-7)26-10-1-2-11(27(24,25)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/s2
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n/an/an/an/a 13n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373023
PNG
(US9896418, Compound 203)
Show SMILES [O-][N+](=O)c1c(Cl)c(ccc1Oc1cc(F)cc(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C13H5Cl2F4NO3/c14-6-3-7(16)5-8(4-6)23-10-2-1-9(13(17,18)19)11(15)12(10)20(21)22/h1-5H
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n/an/an/an/a 700n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373024
PNG
(US9896418, Compound 225)
Show SMILES O[C@@H]1[C@H](F)Cc2c1c(ccc2Oc1cncc(c1)C#N)S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C16H10F4N2O4S/c17-11-4-10-12(26-9-3-8(5-21)6-22-7-9)1-2-13(14(10)15(11)23)27(24,25)16(18,19)20/h1-3,6-7,11,15,23H,4H2/t11-,15-/s2
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n/an/an/an/a 69n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373031
PNG
(US9896418, Compound 236)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cccc(c1)C#N)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C17H11F4NO4S/c18-16(19)27(24,25)13-5-4-12(11-7-17(20,21)15(23)14(11)13)26-10-3-1-2-9(6-10)8-22/h1-6,15-16,23H,7H2/t15-/s2
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n/an/an/an/a 16n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373040
PNG
(US9896418, Compound 289)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)[C@@H](F)[C@@H](O)c12
Show InChI InChI=1/C17H12F3NO4S/c1-26(23,24)12-3-2-11(13-14(12)17(22)16(20)15(13)19)25-10-5-8(7-21)4-9(18)6-10/h2-6,15-17,22H,1H3/t15-,16-,17+/s2
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n/an/an/an/a 18n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373050
PNG
(US9896418, Compound 316 | US9896418, Compound 317)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1/C18H11F4N3O3S/c1-29(27,25-8-24)13-3-2-12(14-15(13)17(26)18(21,22)16(14)20)28-11-5-9(7-23)4-10(19)6-11/h2-6,16-17,26H,1H3/t16-,17+,29?/s2
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n/an/an/an/a 14n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372996
PNG
(US9896418, Compound 80)
Show SMILES OCc1c(Br)c(Oc2cc(F)cc(c2)C#N)ccc1S(=O)(=O)C(F)F
Show InChI InChI=1S/C15H9BrF3NO4S/c16-14-11(7-21)13(25(22,23)15(18)19)2-1-12(14)24-10-4-8(6-20)3-9(17)5-10/h1-5,15,21H,7H2
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n/an/an/an/a 630n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372966
PNG
(US9896418, Compound 9)
Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2
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n/an/an/an/a 6n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373008
PNG
(US9896418, Compound 163)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/s2
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n/an/an/an/a 42n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373011
PNG
(US9896418, Compound 165)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](N)c12
Show InChI InChI=1/C17H13F3N2O3S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16H,7,22H2,1H3/t16-/s2
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US Patent
n/an/an/an/a 560n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373012
PNG
(US9896418, Compound 166)
Show SMILES Cc1cc(Oc2ccc(c3[C@H](O)C(F)(F)Cc23)S(=O)(=O)CF)cc(c1)C#N
Show InChI InChI=1/C18H14F3NO4S/c1-10-4-11(8-22)6-12(5-10)26-14-2-3-15(27(24,25)9-19)16-13(14)7-18(20,21)17(16)23/h2-6,17,23H,7,9H2,1H3/t17-/s2
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n/an/an/an/a 70n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373025
PNG
(US9896418, Compound 228)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(c1)C#N)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C17H9F6NO4S/c18-11-2-1-9(5-8(11)7-24)28-12-3-4-13(29(26,27)17(21,22)23)14-10(12)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/s2
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n/an/an/an/a 28n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373030
PNG
(US9896418, Compound 235)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(c1)C#N)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C16H9F5N2O4S/c17-15(18)4-10-11(27-9-3-8(5-22)6-23-7-9)1-2-12(13(10)14(15)24)28(25,26)16(19,20)21/h1-3,6-7,14,24H,4H2/t14-/s2
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n/an/an/an/a 28n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373047
PNG
(US9896418, Compound 309)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(F)c1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C15H9F6NO4S/c16-7-3-8(6-22-5-7)26-10-1-2-11(27(24,25)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/s2
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n/an/an/an/a 26n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372995
PNG
(US9896418, Compound 78)
Show SMILES OC1CCc2c1c(ccc2Oc1cc(F)cc(c1)C#N)S(=O)(=O)C(F)F
Show InChI InChI=1/C17H12F3NO4S/c18-10-5-9(8-21)6-11(7-10)25-14-3-4-15(26(23,24)17(19)20)16-12(14)1-2-13(16)22/h3-7,13,17,22H,1-2H2
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n/an/an/an/a 750n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372997
PNG
(US9896418, Compound 98)
Show SMILES Fc1cc(Cl)cc(Oc2ccc(c(C#N)c2Br)S(=O)(=O)C(F)(F)F)c1
Show InChI InChI=1S/C14H5BrClF4NO3S/c15-13-10(6-21)12(25(22,23)14(18,19)20)2-1-11(13)24-9-4-7(16)3-8(17)5-9/h1-5H
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n/an/an/an/a 1.58E+3n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372979
PNG
(US9896418, Compound 17)
Show SMILES OC1CCc2c1c(ccc2Oc1cc(F)cc(Cl)c1)S(=O)(=O)C(F)F
Show InChI InChI=1/C16H12ClF3O4S/c17-8-5-9(18)7-10(6-8)24-13-3-4-14(25(22,23)16(19)20)15-11(13)1-2-12(15)21/h3-7,12,16,21H,1-2H2
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n/an/an/an/a 160n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373029
PNG
(US9896418, Compound 234)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(Cl)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C17H12ClF2NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/s2
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n/an/an/an/a 50n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372988
PNG
(US9896418, Compound 41)
Show SMILES OCc1c(Cl)c(Oc2cc(F)cc(Cl)c2)ccc1S(=O)(=O)C(F)F
Show InChI InChI=1S/C14H9Cl2F3O4S/c15-7-3-8(17)5-9(4-7)23-11-1-2-12(10(6-20)13(11)16)24(21,22)14(18)19/h1-5,14,20H,6H2
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n/an/an/an/a 570n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372960
PNG
(US9896418, Compound 1)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(Cl)c1)S(=O)(=O)C(F)F
Show InChI InChI=1/C16H12ClF3O4S/c17-8-5-9(18)7-10(6-8)24-13-3-4-14(25(22,23)16(19)20)15-11(13)1-2-12(15)21/h3-7,12,16,21H,1-2H2/t12-/s2
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n/an/an/an/a 250n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372964
PNG
(US9896418, Compound 8)
Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C16H10ClF5O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2
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n/an/an/an/a 33n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372972
PNG
(US9896418, Compound 11)
Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2
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n/an/an/an/a 15n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372976
PNG
(US9896418, Compound 15)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2/t15-/s2
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n/an/an/an/a 13n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373015
PNG
(US9896418, Compound 185)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C17H9F6NO4S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(26,27)17(21,22)23)14-11(12)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/s2
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n/an/an/an/a 4n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373017
PNG
(US9896418, Compound 188)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)c(F)c(F)c1)ccc2S(=O)(=O)CF
Show InChI InChI=1/C16H10F6O4S/c17-6-27(24,25)12-2-1-11(8-5-16(21,22)15(23)13(8)12)26-7-3-9(18)14(20)10(19)4-7/h1-4,15,23H,5-6H2/t15-/s2
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n/an/an/an/a 88n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372987
PNG
(US9896418, Compound 34)
Show SMILES Cc1c(C#N)c(Oc2cc(F)cc(F)c2)ccc1S(=O)(=O)C(F)F
Show InChI InChI=1S/C15H9F4NO3S/c1-8-12(7-20)13(2-3-14(8)24(21,22)15(18)19)23-11-5-9(16)4-10(17)6-11/h2-6,15H,1H3
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n/an/an/an/a 460n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372990
PNG
(US9896418, Compound 60)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)S(=O)(=O)CF
Show InChI InChI=1/C16H13F3O4S/c17-8-24(21,22)15-4-3-14(12-1-2-13(20)16(12)15)23-11-6-9(18)5-10(19)7-11/h3-7,13,20H,1-2,8H2/t13-/s2
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n/an/an/an/a 40n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372961
PNG
(US9896418, Compound 2)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)S(=O)(=O)C(F)F
Show InChI InChI=1/C16H12F4O4S/c17-8-5-9(18)7-10(6-8)24-13-3-4-14(25(22,23)16(19)20)15-11(13)1-2-12(15)21/h3-7,12,16,21H,1-2H2/t12-/s2
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n/an/an/an/a 62n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373000
PNG
(US9896418, Compound 124)
Show SMILES FC(F)c1cc(ccc1Oc1cc(F)cc(Cl)c1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C14H7ClF6O3S/c15-7-3-8(16)5-9(4-7)24-12-2-1-10(6-11(12)13(17)18)25(22,23)14(19,20)21/h1-6,13H
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PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373003
PNG
(US9896418, Compound 155)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(c1)C#N)S(=O)(=O)C(F)F
Show InChI InChI=1/C17H12F3NO4S/c18-10-5-9(8-21)6-11(7-10)25-14-3-4-15(26(23,24)17(19)20)16-12(14)1-2-13(16)22/h3-7,13,17,22H,1-2H2/t13-/s2
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n/an/an/an/a 140n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373021
PNG
(US9896418, Compound 196)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C16H10F6O4S/c17-9-2-1-7(5-10(9)18)26-11-3-4-12(27(24,25)15(19)20)13-8(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/s2
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n/an/an/an/a 47n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373035
PNG
(US9896418, Compound 252)
Show SMILES NS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C16H11F3N2O4S/c17-9-3-8(7-20)4-10(5-9)25-12-1-2-13(26(21,23)24)14-11(12)6-16(18,19)15(14)22/h1-5,15,22H,6H2,(H2,21,23,24)/t15-/s2
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n/an/an/an/a 130n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373038
PNG
(US9896418, Compound 267)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(c[n+]([O-])c1)C#N)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C16H9F5N2O5S/c17-15(18)4-10-11(28-9-3-8(5-22)6-23(25)7-9)1-2-12(13(10)14(15)24)29(26,27)16(19,20)21/h1-3,6-7,14,24H,4H2/t14-/s2
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n/an/an/an/a 830n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373041
PNG
(US9896418, Compound 292)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1/C17H11F4NO4S/c1-27(24,25)12-3-2-11(13-14(12)16(23)17(20,21)15(13)19)26-10-5-8(7-22)4-9(18)6-10/h2-6,15-16,23H,1H3/t15-,16+/s2
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n/an/an/an/a 6.20n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373043
PNG
(US9896418, Compound 304)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(Br)c2)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C16H12BrF3O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/s2
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n/an/an/an/a 62n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM375337
PNG
(US9908845, Compound 67)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2C#N
Show InChI InChI=1/C16H9F4NO2/c17-9-3-10(18)5-11(4-9)23-13-2-1-8(7-21)14-12(13)6-16(19,20)15(14)22/h1-5,15,22H,6H2/t15-/s2
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n/an/an/an/a 220n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373032
PNG
(US9896418, Compound 240 | US9896418, Compound 245)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C18H12F3N3O3S/c1-28(26,24-9-23)15-3-2-14(13-7-18(20,21)17(25)16(13)15)27-12-5-10(8-22)4-11(19)6-12/h2-6,17,25H,7H2,1H3/t17-,28?/s2
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n/an/an/an/a 81n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373032
PNG
(US9896418, Compound 240 | US9896418, Compound 245)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C18H12F3N3O3S/c1-28(26,24-9-23)15-3-2-14(13-7-18(20,21)17(25)16(13)15)27-12-5-10(8-22)4-11(19)6-12/h2-6,17,25H,7H2,1H3/t17-,28?/s2
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n/an/an/an/a 160n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373036
PNG
(US9896418, Compound 254)
Show SMILES CNS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C17H13F3N2O4S/c1-22-27(24,25)14-3-2-13(12-7-17(19,20)16(23)15(12)14)26-11-5-9(8-21)4-10(18)6-11/h2-6,16,22-23H,7H2,1H3/t16-/s2
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n/an/an/an/a 180n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373042
PNG
(US9896418, Compound 273)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2C(F)(F)F
Show InChI InChI=1/C17H9F6NO2/c18-9-3-8(7-24)4-10(5-9)26-13-2-1-12(17(21,22)23)14-11(13)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/s2
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n/an/an/an/a 6.20n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373048
PNG
(US9896418, Compound 310)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)c[n+]([O-])c1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C15H9F6NO5S/c16-7-3-8(6-22(24)5-7)27-10-1-2-11(28(25,26)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/s2
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n/an/an/an/a 140n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373050
PNG
(US9896418, Compound 316 | US9896418, Compound 317)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1/C18H11F4N3O3S/c1-29(27,25-8-24)13-3-2-12(14-15(13)17(26)18(21,22)16(14)20)28-11-5-9(7-23)4-10(19)6-11/h2-6,16-17,26H,1H3/t16-,17+,29?/s2
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n/an/an/an/a 17n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372989
PNG
(US9896418, Compound 55)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C16H11F5O4S/c17-8-5-9(18)7-10(6-8)25-13-3-4-14(26(23,24)16(19,20)21)15-11(13)1-2-12(15)22/h3-7,12,22H,1-2H2/t12-/s2
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n/an/an/an/a 35n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372994
PNG
(US9896418, Compound 74)
Show SMILES OCc1c(Br)c(Oc2cc(F)cc(Cl)c2)ccc1S(=O)(=O)C(F)F
Show InChI InChI=1S/C14H9BrClF3O4S/c15-13-10(6-20)12(24(21,22)14(18)19)2-1-11(13)23-9-4-7(16)3-8(17)5-9/h1-5,14,20H,6H2
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n/an/an/an/a 320n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM372998
PNG
(US9896418, Compound 99)
Show SMILES FC(F)(F)S(=O)(=O)c1ccc(Oc2cccc(c2)C#N)c(Br)c1C#N
Show InChI InChI=1S/C15H6BrF3N2O3S/c16-14-11(8-21)13(25(22,23)15(17,18)19)5-4-12(14)24-10-3-1-2-9(6-10)7-20/h1-6H
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n/an/an/an/a 550n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373004
PNG
(US9896418, Compound 158)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1/C16H10ClF5O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/s2
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n/an/an/an/a 6n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373013
PNG
(US9896418, Compound 167)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(Cl)cc(c1)C#N)ccc2S(=O)(=O)CF
Show InChI InChI=1/C17H11ClF3NO4S/c18-10-3-9(7-22)4-11(5-10)26-13-1-2-14(27(24,25)8-19)15-12(13)6-17(20,21)16(15)23/h1-5,16,23H,6,8H2/t16-/s2
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n/an/an/an/a 38n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373014
PNG
(US9896418, Compound 179)
Show SMILES Fc1cc(Cl)cc(Oc2ccc(c(Cl)c2Br)S(=O)(=O)C(F)(F)F)c1
Show InChI InChI=1S/C13H5BrCl2F4O3S/c14-11-9(23-8-4-6(15)3-7(17)5-8)1-2-10(12(11)16)24(21,22)13(18,19)20/h1-5H
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n/an/an/an/a 1.60E+3n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373026
PNG
(US9896418, Compound 230)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)cc1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C16H10F6O4S/c17-8-1-3-9(4-2-8)26-11-5-6-12(27(24,25)16(20,21)22)13-10(11)7-15(18,19)14(13)23/h1-6,14,23H,7H2/t14-/s2
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n/an/an/an/a 29n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373027
PNG
(US9896418, Compound 231)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2C[C@@H](F)[C@@H](O)c12
Show InChI InChI=1/C17H13F2NO4S/c1-25(22,23)15-3-2-14(12-7-13(19)17(21)16(12)15)24-11-5-9(8-20)4-10(18)6-11/h2-6,13,17,21H,7H2,1H3/t13-,17-/s2
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n/an/an/an/a 67n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373028
PNG
(US9896418, Compound 233)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/s2
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n/an/an/an/a 15n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373034
PNG
(US9896418, Compound 251)
Show SMILES CNS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C16H13F4NO4S/c1-21-26(23,24)13-3-2-12(11-7-16(19,20)15(22)14(11)13)25-10-5-8(17)4-9(18)6-10/h2-6,15,21-22H,7H2,1H3/t15-/s2
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n/an/an/an/a 48n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373037
PNG
(US9896418, Compound 256)
Show SMILES NS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C15H11F4NO4S/c16-7-3-8(17)5-9(4-7)24-11-1-2-12(25(20,22)23)13-10(11)6-15(18,19)14(13)21/h1-5,14,21H,6H2,(H2,20,22,23)/t14-/s2
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n/an/an/an/a 65n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373044
PNG
(US9896418, Compound 305 | US9896418, Compound 306)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=N)(=O)C(F)(F)F
Show InChI InChI=1/C17H10F6N2O3S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(25,27)17(21,22)23)14-11(12)6-16(19,20)15(14)26/h1-5,15,25-26H,6H2/t15-,29?/s2
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 19.5n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373049
PNG
(US9896418, Compound 325)
Show SMILES CS(=O)(=O)c1ccc(Oc2cncc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1/C16H12F2N2O4S/c1-25(22,23)13-3-2-12(11-5-16(17,18)15(21)14(11)13)24-10-4-9(6-19)7-20-8-10/h2-4,7-8,15,21H,5H2,1H3/t15-/s2
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 150n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373052
PNG
(US9896418, Compound 342)
Show SMILES CS(=O)(=O)c1ccc(Oc2cncc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1/C16H11F3N2O4S/c1-26(23,24)11-3-2-10(25-9-4-8(5-20)6-21-7-9)12-13(11)15(22)16(18,19)14(12)17/h2-4,6-7,14-15,22H,1H3/t14-,15+/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 52n/an/an/an/a



PELOTON THERAPEUTICS, INC.

US Patent


Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


US Patent US9908845 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%