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Patent code US9908886

Compile Data Set for Download or QSAR

Found 266 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375543
PNG
(4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imid...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H23N5O/c1-29-12-14-30(15-13-29)26(32)22-8-6-20(7-9-22)23-10-11-25-28-17-24(31(25)18-23)21-4-2-19(16-27)3-5-21/h2-11,17-18H,12-15H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375546
PNG
(4-(6-(4-(1,4-oxazepane-4-carbonyl)phenyl imidazo[1...)
Show SMILES O=C(N1CCCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H22N4O2/c27-16-19-2-4-21(5-3-19)24-17-28-25-11-10-23(18-30(24)25)20-6-8-22(9-7-20)26(31)29-12-1-14-32-15-13-29/h2-11,17-18H,1,12-15H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375547
PNG
(4-(6-(4-(4-ethylpiperazine-1-carbonyl)phenyl)imida...)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C27H25N5O/c1-2-30-13-15-31(16-14-30)27(33)23-9-7-21(8-10-23)24-11-12-26-29-18-25(32(26)19-24)22-5-3-20(17-28)4-6-22/h3-12,18-19H,2,13-16H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375548
PNG
(N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-...)
Show SMILES CC(=O)NC1(C)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C29H27N5O2/c1-20(35)32-29(2)13-15-33(16-14-29)28(36)24-9-7-22(8-10-24)25-11-12-27-31-18-26(34(27)19-25)23-5-3-21(17-30)4-6-23/h3-12,18-19H,13-16H2,1-2H3,(H,32,35)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375550
PNG
(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-N-...)
Show SMILES CN(CC(=O)N1CCOCC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C28H25N5O3/c1-31(19-27(34)32-12-14-36-15-13-32)28(35)23-8-6-21(7-9-23)24-10-11-26-30-17-25(33(26)18-24)22-4-2-20(16-29)3-5-22/h2-11,17-18H,12-15,19H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375551
PNG
(4-(6-(4-(3-oxopiperazine-1-carbonyl)phenyl)imidazo...)
Show SMILES O=C(N1CCNC(=O)C1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C25H19N5O2/c26-13-17-1-3-19(4-2-17)22-14-28-23-10-9-21(15-30(22)23)18-5-7-20(8-6-18)25(32)29-12-11-27-24(31)16-29/h1-10,14-15H,11-12,16H2,(H,27,31)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375556
PNG
(4-(6-(4-(4-aminopiperidine-1-carbonyl)phenyl)imida...)
Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H23N5O/c27-15-18-1-3-20(4-2-18)24-16-29-25-10-9-22(17-31(24)25)19-5-7-21(8-6-19)26(32)30-13-11-23(28)12-14-30/h1-10,16-17,23H,11-14,28H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375559
PNG
(4-(6-(4-(4-amino-4-ethylpiperidine-1-carbonyl)phen...)
Show SMILES CCC1(N)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C28H27N5O/c1-2-28(30)13-15-32(16-14-28)27(34)23-9-7-21(8-10-23)24-11-12-26-31-18-25(33(26)19-24)22-5-3-20(17-29)4-6-22/h3-12,18-19H,2,13-16,30H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375563
PNG
(4-(6-(4-(1-acetyl-1,9-diazaspiro[5.5]undecane-9-ca...)
Show SMILES CC(=O)N1CCCCC11CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C32H31N5O2/c1-23(38)37-17-3-2-14-32(37)15-18-35(19-16-32)31(39)27-10-8-25(9-11-27)28-12-13-30-34-21-29(36(30)22-28)26-6-4-24(20-33)5-7-26/h4-13,21-22H,2-3,14-19H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375569
PNG
(4-(6-(4-(4-benzoylpiperazine-1-carbonyl)phenyl)imi...)
Show SMILES O=C(N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1)c1ccccc1
Show InChI InChI=1S/C32H25N5O2/c33-20-23-6-8-25(9-7-23)29-21-34-30-15-14-28(22-37(29)30)24-10-12-27(13-11-24)32(39)36-18-16-35(17-19-36)31(38)26-4-2-1-3-5-26/h1-15,21-22H,16-19H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375584
PNG
(4-(6-(3-hydroxy-4-(4-methylpiperazine-1-carbonyl)p...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(c(O)c1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H23N5O2/c1-29-10-12-30(13-11-29)26(33)20-6-8-22(24(32)14-20)21-7-9-25-28-16-23(31(25)17-21)19-4-2-18(15-27)3-5-19/h2-9,14,16-17,32H,10-13H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375590
PNG
(4-(6-(3-(methylamino)-4-(4-methylpiperazine-1-carb...)
Show SMILES CNc1cc(ccc1C(=O)N1CCN(C)CC1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C27H26N6O/c1-29-24-15-21(7-9-23(24)27(34)32-13-11-31(2)12-14-32)22-8-10-26-30-17-25(33(26)18-22)20-5-3-19(16-28)4-6-20/h3-10,15,17-18,29H,11-14H2,1-2H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375597
PNG
(4-(6-(3-hydroxy-4-(piperazine-1-carbonyl)phenyl)im...)
Show SMILES OCc1cc(ccc1C(=O)N1CCNCC1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H23N5O2/c27-14-18-1-3-19(4-2-18)24-15-29-25-8-6-21(16-31(24)25)20-5-7-23(22(13-20)17-32)26(33)30-11-9-28-10-12-30/h1-8,13,15-16,28,32H,9-12,17H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375601
PNG
(4-(6-(4-(4-methyl-4-(4-methylpiperazin-1-yl)piperi...)
Show SMILES CN1CCN(CC1)C1(C)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C32H34N6O/c1-32(37-19-17-35(2)18-20-37)13-15-36(16-14-32)31(39)27-9-7-25(8-10-27)28-11-12-30-34-22-29(38(30)23-28)26-5-3-24(21-33)4-6-26/h3-12,22-23H,13-20H2,1-2H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375605
PNG
(N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)...)
Show SMILES CC(=O)Nc1cc(ccc1C(=O)N1CCNCC1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C27H24N6O2/c1-18(34)31-24-14-21(6-8-23(24)27(35)32-12-10-29-11-13-32)22-7-9-26-30-16-25(33(26)17-22)20-4-2-19(15-28)3-5-20/h2-9,14,16-17,29H,10-13H2,1H3,(H,31,34)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375614
PNG
(4-(5-(4-(1,4-oxazepane-4-carbonyl)phenyl)pyrazolo[...)
Show SMILES O=C(N1CCCOCC1)c1ccc(cc1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1
Show InChI InChI=1S/C25H21N5O2/c26-16-18-2-4-19(5-3-18)22-17-27-30-12-10-23(28-24(22)30)20-6-8-21(9-7-20)25(31)29-11-1-14-32-15-13-29/h2-10,12,17H,1,11,13-15H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375616
PNG
(4-(5-(4-(piperazine-1-carbonyl)phenyl)pyrazolo[1,5...)
Show SMILES O=C(N1CCNCC1)c1ccc(cc1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1
Show InChI InChI=1S/C24H20N6O/c25-15-17-1-3-18(4-2-17)21-16-27-30-12-9-22(28-23(21)30)19-5-7-20(8-6-19)24(31)29-13-10-26-11-14-29/h1-9,12,16,26H,10-11,13-14H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375616
PNG
(4-(5-(4-(piperazine-1-carbonyl)phenyl)pyrazolo[1,5...)
Show SMILES O=C(N1CCNCC1)c1ccc(cc1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1
Show InChI InChI=1S/C24H20N6O/c25-15-17-1-3-18(4-2-17)21-16-27-30-12-9-22(28-23(21)30)19-5-7-20(8-6-19)24(31)29-13-10-26-11-14-29/h1-9,12,16,26H,10-11,13-14H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375618
PNG
(4-(5-(4-(morpholine-4-carbonyl)phenyl)pyrazolo[1,5...)
Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1
Show InChI InChI=1S/C24H19N5O2/c25-15-17-1-3-18(4-2-17)21-16-26-29-10-9-22(27-23(21)29)19-5-7-20(8-6-19)24(30)28-11-13-31-14-12-28/h1-10,16H,11-14H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375621
PNG
(N-(5-(3-(4-cyanophenol)pyrazolo[1,5-a]pyrimidin-5-...)
Show SMILES N=COCc1cc(ccc1C(=O)N1CCOCC1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1
Show InChI InChI=1S/C26H22N6O3/c27-14-18-1-3-19(4-2-18)23-15-29-32-8-7-24(30-25(23)32)20-5-6-22(21(13-20)16-35-17-28)26(33)31-9-11-34-12-10-31/h1-8,13,15,17,28H,9-12,16H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375514
PNG
(4-(6-(4-(4-hydroxypiperidine-1-carbonyl)phenyl)imi...)
Show SMILES OC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C25H21N5O2/c26-15-17-1-3-19(4-2-17)23-16-27-24-10-9-22(28-30(23)24)18-5-7-20(8-6-18)25(32)29-13-11-21(31)12-14-29/h1-10,16,21,31H,11-14H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375519
PNG
(4-(6-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)i...)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C27H26N6O/c1-19(2)31-13-15-32(16-14-31)27(34)23-9-7-21(8-10-23)24-11-12-26-29-18-25(33(26)30-24)22-5-3-20(17-28)4-6-22/h3-12,18-19H,13-16H2,1-2H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375521
PNG
(4-(6-(4-(4-(methylamino)piperidine-1-carbonyl)phen...)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C26H24N6O/c1-2-30-13-15-31(16-14-30)26(33)22-9-7-20(8-10-22)23-11-12-25-28-18-24(32(25)29-23)21-5-3-19(17-27)4-6-21/h3-12,18H,2,13-16H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375524
PNG
(4-(6-(4-(1,4-oxazepane-4-carbonyl)phenyl)imidazo[1...)
Show SMILES O=C(N1CCCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C25H21N5O2/c26-16-18-2-4-20(5-3-18)23-17-27-24-11-10-22(28-30(23)24)19-6-8-21(9-7-19)25(31)29-12-1-14-32-15-13-29/h2-11,17H,1,12-15H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375526
PNG
(N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-...)
Show SMILES CCC1(CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1)NC(C)=O
Show InChI InChI=1S/C29H28N6O2/c1-3-29(32-20(2)36)14-16-34(17-15-29)28(37)24-10-8-22(9-11-24)25-12-13-27-31-19-26(35(27)33-25)23-6-4-21(18-30)5-7-23/h4-13,19H,3,14-17H2,1-2H3,(H,32,36)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375533
PNG
(4-(6-(3-methyl-4-(4-methylpiperazine-1-carbonyl)ph...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1C)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C26H24N6O/c1-18-15-21(7-8-22(18)26(33)31-13-11-30(2)12-14-31)23-9-10-25-28-17-24(32(25)29-23)20-5-3-19(16-27)4-6-20/h3-10,15,17H,11-14H2,1-2H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375535
PNG
(4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophe...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1[N+]([O-])=O)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C25H21N7O3/c1-29-10-12-30(13-11-29)25(33)20-7-6-19(14-22(20)32(34)35)21-8-9-24-27-16-23(31(24)28-21)18-4-2-17(15-26)3-5-18/h2-9,14,16H,10-13H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375536
PNG
(N-(5-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-y...)
Show SMILES [O-][N+](=O)c1cc(ccc1C(=O)N1CCOCC1)-c1ccc2ncc(I)n2n1
Show InChI InChI=1S/C17H14IN5O4/c18-15-10-19-16-4-3-13(20-22(15)16)11-1-2-12(14(9-11)23(25)26)17(24)21-5-7-27-8-6-21/h1-4,9-10H,5-8H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375541
PNG
(5-(6-(4-(4-(4-methylpiperazin-1-yl)piperidine-1-ca...)
Show SMILES CN1CCN(CC1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc4NC(=O)Cc4c3)n2n1
Show InChI InChI=1S/C31H33N7O2/c1-35-14-16-36(17-15-35)25-10-12-37(13-11-25)31(40)22-4-2-21(3-5-22)27-8-9-29-32-20-28(38(29)34-27)23-6-7-26-24(18-23)19-30(39)33-26/h2-9,18,20,25H,10-17,19H2,1H3,(H,33,39)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375544
PNG
(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375548
PNG
(N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-...)
Show SMILES CC(=O)NC1(C)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C29H27N5O2/c1-20(35)32-29(2)13-15-33(16-14-29)28(36)24-9-7-22(8-10-24)25-11-12-27-31-18-26(34(27)19-25)23-5-3-21(17-30)4-6-23/h3-12,18-19H,13-16H2,1-2H3,(H,32,35)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375550
PNG
(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-N-...)
Show SMILES CN(CC(=O)N1CCOCC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C28H25N5O3/c1-31(19-27(34)32-12-14-36-15-13-32)28(35)23-8-6-21(7-9-23)24-10-11-26-30-17-25(33(26)18-24)22-4-2-20(16-29)3-5-22/h2-11,17-18H,12-15,19H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375551
PNG
(4-(6-(4-(3-oxopiperazine-1-carbonyl)phenyl)imidazo...)
Show SMILES O=C(N1CCNC(=O)C1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C25H19N5O2/c26-13-17-1-3-19(4-2-17)22-14-28-23-10-9-21(15-30(22)23)18-5-7-20(8-6-18)25(32)29-12-11-27-24(31)16-29/h1-10,14-15H,11-12,16H2,(H,27,31)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375552
PNG
(4-(6-(4-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)...)
Show SMILES CN1CCCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C27H25N5O/c1-30-13-2-14-31(16-15-30)27(33)23-9-7-21(8-10-23)24-11-12-26-29-18-25(32(26)19-24)22-5-3-20(17-28)4-6-22/h3-12,18-19H,2,13-16H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375553
PNG
(4-(6-(4-(1′-methyl-4,4′-bipiperidine-1...)
Show SMILES CN1CCC(CC1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C32H33N5O/c1-35-16-12-25(13-17-35)26-14-18-36(19-15-26)32(38)28-8-6-24(7-9-28)29-10-11-31-34-21-30(37(31)22-29)27-4-2-23(20-33)3-5-27/h2-11,21-22,25-26H,12-19H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375556
PNG
(4-(6-(4-(4-aminopiperidine-1-carbonyl)phenyl)imida...)
Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H23N5O/c27-15-18-1-3-20(4-2-18)24-16-29-25-10-9-22(17-31(24)25)19-5-7-21(8-6-19)26(32)30-13-11-23(28)12-14-30/h1-10,16-17,23H,11-14,28H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375581
PNG
(4-(6-(3-chloro-4-(4-methylpiperazine-1-carbonyl)ph...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1Cl)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H22ClN5O/c1-30-10-12-31(13-11-30)26(33)22-8-6-20(14-23(22)27)21-7-9-25-29-16-24(32(25)17-21)19-4-2-18(15-28)3-5-19/h2-9,14,16-17H,10-13H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375586
PNG
(4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-(trifluo...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1C(F)(F)F)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C27H22F3N5O/c1-33-10-12-34(13-11-33)26(36)22-8-6-20(14-23(22)27(28,29)30)21-7-9-25-32-16-24(35(25)17-21)19-4-2-18(15-31)3-5-19/h2-9,14,16-17H,10-13H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375604
PNG
(4-(6-(3-hydroxy-4-(morpholine-4-carbonyl)phenyl)im...)
Show SMILES OCc1cc(ccc1C(=O)N1CCOCC1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H22N4O3/c27-14-18-1-3-19(4-2-18)24-15-28-25-8-6-21(16-30(24)25)20-5-7-23(22(13-20)17-31)26(32)29-9-11-33-12-10-29/h1-8,13,15-16,31H,9-12,17H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375605
PNG
(N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)...)
Show SMILES CC(=O)Nc1cc(ccc1C(=O)N1CCNCC1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C27H24N6O2/c1-18(34)31-24-14-21(6-8-23(24)27(35)32-12-10-29-11-13-32)22-7-9-26-30-16-25(33(26)17-22)20-4-2-19(15-28)3-5-20/h2-9,14,16-17,29H,10-13H2,1H3,(H,31,34)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375610
PNG
((4-aminopiperidin-1-yl)(4-(3-(4-chlorophenyl)imida...)
Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(Cl)cc3)n2c1
Show InChI InChI=1S/C25H23ClN4O/c26-21-8-5-18(6-9-21)23-15-28-24-10-7-20(16-30(23)24)17-1-3-19(4-2-17)25(31)29-13-11-22(27)12-14-29/h1-10,15-16,22H,11-14,27H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375611
PNG
((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-6-yl)...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(I)n2c1
Show InChI InChI=1S/C19H19IN4O/c1-22-8-10-23(11-9-22)19(25)15-4-2-14(3-5-15)16-6-7-18-21-12-17(20)24(18)13-16/h2-7,12-13H,8-11H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375621
PNG
(N-(5-(3-(4-cyanophenol)pyrazolo[1,5-a]pyrimidin-5-...)
Show SMILES N=COCc1cc(ccc1C(=O)N1CCOCC1)-c1ccn2ncc(-c3ccc(cc3)C#N)c2n1
Show InChI InChI=1S/C26H22N6O3/c27-14-18-1-3-19(4-2-18)23-15-29-32-8-7-24(30-25(23)32)20-5-6-22(21(13-20)16-35-17-28)26(33)31-9-11-34-12-10-31/h1-8,13,15,17,28H,9-12,16H2
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MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375313
PNG
((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(O)cc1
Show InChI InChI=1S/C24H23N5O2/c1-27-10-12-28(13-11-27)24(31)19-4-2-17(3-5-19)21-16-29-22(14-26-23(29)15-25-21)18-6-8-20(30)9-7-18/h2-9,14-16,30H,10-13H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375515
PNG
(4-(6-(4-(4-aminopiperidine-1-carbonyl)phenyl)imida...)
Show SMILES NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C25H22N6O/c26-15-17-1-3-19(4-2-17)23-16-28-24-10-9-22(29-31(23)24)18-5-7-20(8-6-18)25(32)30-13-11-21(27)12-14-30/h1-10,16,21H,11-14,27H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375516
PNG
(N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-...)
Show SMILES CC(=O)NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C27H24N6O2/c1-18(34)30-23-12-14-32(15-13-23)27(35)22-8-6-20(7-9-22)24-10-11-26-29-17-25(33(26)31-24)21-4-2-19(16-28)3-5-21/h2-11,17,23H,12-15H2,1H3,(H,30,34)
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375517
PNG
(4-(6-(4-(4-amino-4-methylpiperidine-1-carbonyl)phe...)
Show SMILES CC1(N)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C26H24N6O/c1-26(28)12-14-31(15-13-26)25(33)21-8-6-19(7-9-21)22-10-11-24-29-17-23(32(24)30-22)20-4-2-18(16-27)3-5-20/h2-11,17H,12-15,28H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375519
PNG
(4-(6-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)i...)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C27H26N6O/c1-19(2)31-13-15-32(16-14-31)27(34)23-9-7-21(8-10-23)24-11-12-26-29-18-25(33(26)30-24)22-5-3-20(17-28)4-6-22/h3-12,18-19H,13-16H2,1-2H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375520
PNG
(4-(6-(4-(4-(methylamino)piperidine-1-carbonyl)phen...)
Show SMILES CNC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C26H24N6O/c1-28-22-12-14-31(15-13-22)26(33)21-8-6-19(7-9-21)23-10-11-25-29-17-24(32(25)30-23)20-4-2-18(16-27)3-5-20/h2-11,17,22,28H,12-15H2,1H3
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375522
PNG
(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C24H19N5O2/c25-15-17-1-3-19(4-2-17)22-16-26-23-10-9-21(27-29(22)23)18-5-7-20(8-6-18)24(30)28-11-13-31-14-12-28/h1-10,16H,11-14H2
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Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair
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