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Patent code US9908899

Compile Data Set for Download or QSAR
Found 143 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375724
PNG
(US9908899, Compound D1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H20N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-13,15-16H,14,22H2,(H,24,26)/b9-6+,13-12+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375739
PNG
(US9908899, Compound D4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C19H18N4O/c20-17-8-4-5-9-18(17)22-19(24)11-10-16-12-21-23(14-16)13-15-6-2-1-3-7-15/h1-12,14H,13,20H2,(H,22,24)/b11-10+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375742
PNG
(US9908899, Compound D14)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-8-4-5-9-20(19)24-21(26)11-10-18-14-23-25(15-18)12-13-27-16-17-6-2-1-3-7-17/h1-11,14-15H,12-13,16,22H2,(H,24,26)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375742
PNG
(US9908899, Compound D14)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-8-4-5-9-20(19)24-21(26)11-10-18-14-23-25(15-18)12-13-27-16-17-6-2-1-3-7-17/h1-11,14-15H,12-13,16,22H2,(H,24,26)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375747
PNG
(US9908899, Compound D15)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCOc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-9-4-5-10-20(19)24-21(26)12-11-17-15-23-25(16-17)13-6-14-27-18-7-2-1-3-8-18/h1-5,7-12,15-16H,6,13-14,22H2,(H,24,26)/b12-11+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375756
PNG
(US9908899, Compound A7)
Show SMILES Cn1ccc(\C=C\C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C13H14N4O/c1-17-9-8-10(16-17)6-7-13(18)15-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,15,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375762
PNG
(US9908899, Compound A1)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)cs1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375767
PNG
(US9908899, Compound F1)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC2)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C27H27N3O3/c28-24-8-4-5-9-25(24)29-26(31)23-12-10-20(11-13-23)18-21-14-16-30(17-15-21)27(32)33-19-22-6-2-1-3-7-22/h1-13,18H,14-17,19,28H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375772
PNG
(US9908899, Compound F6)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)c(Cl)c1
Show InChI InChI=1S/C23H21ClN4O/c24-20-11-19(23(29)27-22-6-2-1-5-21(22)25)8-7-18(20)10-17-14-28(15-17)13-16-4-3-9-26-12-16/h1-12H,13-15,25H2,(H,27,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375773
PNG
(US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375738
PNG
(US9908899, Compound A12)
Show SMILES Cn1cnc(\C=C\C(=O)Nc2ccccc2N)c1
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(15-9-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375742
PNG
(US9908899, Compound D14)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-8-4-5-9-20(19)24-21(26)11-10-18-14-23-25(15-18)12-13-27-16-17-6-2-1-3-7-17/h1-11,14-15H,12-13,16,22H2,(H,24,26)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375746
PNG
(US9908899, Compound D13)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C22H21N5O/c23-19-6-2-4-8-21(19)26-22(28)10-9-16-13-25-27(15-16)12-11-17-14-24-20-7-3-1-5-18(17)20/h1-10,13-15,24H,11-12,23H2,(H,26,28)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375747
PNG
(US9908899, Compound D15)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCOc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-9-4-5-10-20(19)24-21(26)12-11-17-15-23-25(16-17)13-6-14-27-18-7-2-1-3-8-18/h1-5,7-12,15-16H,6,13-14,22H2,(H,24,26)/b12-11+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375753
PNG
(US9908899, Compound A10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccnc2s1
Show InChI InChI=1S/C14H12N4OS/c15-11-3-1-2-4-12(11)17-13(19)6-5-10-9-18-8-7-16-14(18)20-10/h1-9H,15H2,(H,17,19)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375759
PNG
(US9908899, Compound A11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c19-16-8-4-5-9-17(16)21-18(23)11-10-14-12-20-22(13-14)15-6-2-1-3-7-15/h1-13H,19H2,(H,21,23)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375761
PNG
(US9908899, Compound B1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC2CC2)c1
Show InChI InChI=1S/C16H18N4O/c17-14-3-1-2-4-15(14)19-16(21)8-7-13-9-18-20(11-13)10-12-5-6-12/h1-4,7-9,11-12H,5-6,10,17H2,(H,19,21)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375772
PNG
(US9908899, Compound F6)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)c(Cl)c1
Show InChI InChI=1S/C23H21ClN4O/c24-20-11-19(23(29)27-22-6-2-1-5-21(22)25)8-7-18(20)10-17-14-28(15-17)13-16-4-3-9-26-12-16/h1-12H,13-15,25H2,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375727
PNG
(US9908899, Compound D9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCCc2ccccc2)c1
Show InChI InChI=1S/C22H24N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-5,8-9,11-14,16-17H,6-7,10,15,23H2,(H,25,27)/b14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375735
PNG
(US9908899, Compound B3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H18F2N4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375737
PNG
(US9908899, Compound B5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(Cl)c2)c1
Show InChI InChI=1S/C20H18ClFN4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375743
PNG
(US9908899, Compound D11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC\C=C\c2ccccc2)c1
Show InChI InChI=1S/C22H22N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-6,8-14,16-17H,7,15,23H2,(H,25,27)/b10-6+,14-13+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375746
PNG
(US9908899, Compound D13)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C22H21N5O/c23-19-6-2-4-8-21(19)26-22(28)10-9-16-13-25-27(15-16)12-11-17-14-24-20-7-3-1-5-18(17)20/h1-10,13-15,24H,11-12,23H2,(H,26,28)/b10-9+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375746
PNG
(US9908899, Compound D13)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C22H21N5O/c23-19-6-2-4-8-21(19)26-22(28)10-9-16-13-25-27(15-16)12-11-17-14-24-20-7-3-1-5-18(17)20/h1-10,13-15,24H,11-12,23H2,(H,26,28)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375748
PNG
(US9908899, Compound D10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC(F)(F)c2ccccc2)c1
Show InChI InChI=1S/C20H18F2N4O/c21-20(22,16-6-2-1-3-7-16)14-26-13-15(12-24-26)10-11-19(27)25-18-9-5-4-8-17(18)23/h1-13H,14,23H2,(H,25,27)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375750
PNG
(US9908899, Compound A6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnc2ccccn12
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-18-15-7-3-4-10-20(12)15/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375752
PNG
(US9908899, Compound A9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccccc2n1
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-20-10-4-3-7-15(20)18-12/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375766
PNG
((E)-N-(2-aminophenyl)-3-(2-cinnamylthiazol-4-yl)ac...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1csc(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C21H19N3OS/c22-18-10-4-5-11-19(18)24-20(25)14-13-17-15-26-21(23-17)12-6-9-16-7-2-1-3-8-16/h1-11,13-15H,12,22H2,(H,24,25)/b9-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375768
PNG
(US9908899, Compound F2)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C25H26N4O/c26-23-5-1-2-6-24(23)28-25(30)22-9-7-19(8-10-22)16-20-11-14-29(15-12-20)18-21-4-3-13-27-17-21/h1-10,13,16-17H,11-12,14-15,18,26H2,(H,28,30)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375770
PNG
(US9908899, Compound F4)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CC2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H26N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-12,14,20,28H,13,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375773
PNG
(US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375728
PNG
(US9908899, Compound B6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-6-8-17(9-7-16)27-12-11-25-14-15(13-23-25)5-10-20(26)24-19-4-2-1-3-18(19)22/h1-10,13-14H,11-12,22H2,(H,24,26)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375735
PNG
(US9908899, Compound B3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H18F2N4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375735
PNG
(US9908899, Compound B3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H18F2N4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375743
PNG
(US9908899, Compound D11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC\C=C\c2ccccc2)c1
Show InChI InChI=1S/C22H22N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-6,8-14,16-17H,7,15,23H2,(H,25,27)/b10-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375743
PNG
(US9908899, Compound D11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC\C=C\c2ccccc2)c1
Show InChI InChI=1S/C22H22N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-6,8-14,16-17H,7,15,23H2,(H,25,27)/b10-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375745
PNG
(US9908899, Compound D12)
Show SMILES CN(CCCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1)c1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-26(19-8-3-2-4-9-19)14-7-15-27-17-18(16-24-27)12-13-22(28)25-21-11-6-5-10-20(21)23/h2-6,8-13,16-17H,7,14-15,23H2,1H3,(H,25,28)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375765
PNG
(US9908899, Compound A5)
Show SMILES Cc1cc(\C=C\C(=O)Nc2ccccc2N)on1
Show InChI InChI=1S/C13H13N3O2/c1-9-8-10(18-16-9)6-7-13(17)15-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,15,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375724
PNG
(US9908899, Compound D1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H20N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-13,15-16H,14,22H2,(H,24,26)/b9-6+,13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375726
PNG
(US9908899, Compound D3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O2/c21-18-8-4-5-9-19(18)23-20(25)11-10-16-14-22-24(15-16)12-13-26-17-6-2-1-3-7-17/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375728
PNG
(US9908899, Compound B6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-6-8-17(9-7-16)27-12-11-25-14-15(13-23-25)5-10-20(26)24-19-4-2-1-3-18(19)22/h1-10,13-14H,11-12,22H2,(H,24,26)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375728
PNG
(US9908899, Compound B6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-6-8-17(9-7-16)27-12-11-25-14-15(13-23-25)5-10-20(26)24-19-4-2-1-3-18(19)22/h1-10,13-14H,11-12,22H2,(H,24,26)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375733
PNG
(US9908899, Compound B2)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccc(F)cc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-10-7-16(8-11-18)4-3-13-26-15-17(14-24-26)9-12-21(27)25-20-6-2-1-5-19(20)23/h1-12,14-15H,13,23H2,(H,25,27)/b4-3+,12-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375734
PNG
(US9908899, Compound B4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375747
PNG
(US9908899, Compound D15)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCOc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-9-4-5-10-20(19)24-21(26)12-11-17-15-23-25(16-17)13-6-14-27-18-7-2-1-3-8-18/h1-5,7-12,15-16H,6,13-14,22H2,(H,24,26)/b12-11+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375748
PNG
(US9908899, Compound D10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC(F)(F)c2ccccc2)c1
Show InChI InChI=1S/C20H18F2N4O/c21-20(22,16-6-2-1-3-7-16)14-26-13-15(12-24-26)10-11-19(27)25-18-9-5-4-8-17(18)23/h1-13H,14,23H2,(H,25,27)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375751
PNG
(US9908899, Compound A8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cc2ccccn2n1
Show InChI InChI=1S/C16H14N4O/c17-14-6-1-2-7-15(14)18-16(21)9-8-12-11-13-5-3-4-10-20(13)19-12/h1-11H,17H2,(H,18,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375763
PNG
(US9908899, Compound A3)
Show SMILES Cc1ncc(\C=C\C(=O)Nc2ccccc2N)s1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-8-10(18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375767
PNG
(US9908899, Compound F1)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC2)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C27H27N3O3/c28-24-8-4-5-9-25(24)29-26(31)23-12-10-20(11-13-23)18-21-14-16-30(17-15-21)27(32)33-19-22-6-2-1-3-7-22/h1-13,18H,14-17,19,28H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375769
PNG
(US9908899, Compound F3)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H24N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-14,28H,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375771
PNG
(US9908899, Compound F5)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)c(Cl)c1
Show InChI InChI=1S/C26H23ClN4O/c27-22-13-21(26(32)30-24-4-2-1-3-23(24)28)8-7-20(22)11-18-15-31(16-18)14-17-5-6-19-9-10-29-25(19)12-17/h1-13,29H,14-16,28H2,(H,30,32)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375775
PNG
(US9908899, Compound G2)
Show SMILES Cc1nn(C\C=C\c2ccccc2)c(C)c1\C=C\C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H24N4O/c1-17-20(14-15-23(28)25-22-13-7-6-12-21(22)24)18(2)27(26-17)16-8-11-19-9-4-3-5-10-19/h3-15H,16,24H2,1-2H3,(H,25,28)/b11-8+,15-14+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375724
PNG
(US9908899, Compound D1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H20N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-13,15-16H,14,22H2,(H,24,26)/b9-6+,13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50254780
PNG
(CHEMBL4078477 | US9908899, Compound D2)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375726
PNG
(US9908899, Compound D3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O2/c21-18-8-4-5-9-19(18)23-20(25)11-10-16-14-22-24(15-16)12-13-26-17-6-2-1-3-7-17/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375727
PNG
(US9908899, Compound D9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCCc2ccccc2)c1
Show InChI InChI=1S/C22H24N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-5,8-9,11-14,16-17H,6-7,10,15,23H2,(H,25,27)/b14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375733
PNG
(US9908899, Compound B2)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccc(F)cc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-10-7-16(8-11-18)4-3-13-26-15-17(14-24-26)9-12-21(27)25-20-6-2-1-5-19(20)23/h1-12,14-15H,13,23H2,(H,25,27)/b4-3+,12-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375736
PNG
(US9908899, Compound D16)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-7-8-19(18(22)12-16)24-20(26)9-6-15-13-23-25(14-15)10-11-27-17-4-2-1-3-5-17/h1-9,12-14H,10-11,22H2,(H,24,26)/b9-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375740
PNG
(US9908899, Compound D7)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O/c21-18-8-4-5-9-19(18)23-20(25)11-10-17-14-22-24(15-17)13-12-16-6-2-1-3-7-16/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375740
PNG
(US9908899, Compound D7)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O/c21-18-8-4-5-9-19(18)23-20(25)11-10-17-14-22-24(15-17)13-12-16-6-2-1-3-7-16/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375741
PNG
(US9908899, Compound D8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-5,7-8,10-13,15-16H,6,9,14,22H2,(H,24,26)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375741
PNG
(US9908899, Compound D8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-5,7-8,10-13,15-16H,6,9,14,22H2,(H,24,26)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375754
PNG
((E)-N-(2-aminophenyl)-3-(6-(ethoxymethyl)imidazo[2...)
Show SMILES CCOCc1cn2cc(\C=C\C(=O)Nc3ccccc3N)sc2n1
Show InChI InChI=1S/C17H18N4O2S/c1-2-23-11-12-9-21-10-13(24-17(21)19-12)7-8-16(22)20-15-6-4-3-5-14(15)18/h3-10H,2,11,18H2,1H3,(H,20,22)/b8-7+
PDB

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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375768
PNG
(US9908899, Compound F2)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C25H26N4O/c26-23-5-1-2-6-24(23)28-25(30)22-9-7-19(8-10-22)16-20-11-14-29(15-12-20)18-21-4-3-13-27-17-21/h1-10,13,16-17H,11-12,14-15,18,26H2,(H,28,30)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375726
PNG
(US9908899, Compound D3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O2/c21-18-8-4-5-9-19(18)23-20(25)11-10-16-14-22-24(15-16)12-13-26-17-6-2-1-3-7-17/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375727
PNG
(US9908899, Compound D9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCCc2ccccc2)c1
Show InChI InChI=1S/C22H24N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-5,8-9,11-14,16-17H,6-7,10,15,23H2,(H,25,27)/b14-13+
PDB

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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375737
PNG
(US9908899, Compound B5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(Cl)c2)c1
Show InChI InChI=1S/C20H18ClFN4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375741
PNG
(US9908899, Compound D8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-5,7-8,10-13,15-16H,6,9,14,22H2,(H,24,26)/b13-12+
PDB

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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375745
PNG
(US9908899, Compound D12)
Show SMILES CN(CCCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1)c1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-26(19-8-3-2-4-9-19)14-7-15-27-17-18(16-24-27)12-13-22(28)25-21-11-6-5-10-20(21)23/h2-6,8-13,16-17H,7,14-15,23H2,1H3,(H,25,28)/b13-12+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375751
PNG
(US9908899, Compound A8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cc2ccccn2n1
Show InChI InChI=1S/C16H14N4O/c17-14-6-1-2-7-15(14)18-16(21)9-8-12-11-13-5-3-4-10-20(13)19-12/h1-11H,17H2,(H,18,21)/b9-8+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375755
PNG
(US9908899, Compound A2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C13H14N4O/c1-17-9-10(8-15-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375760
PNG
(US9908899, Compound C1)
Show SMILES CCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C14H16N4O/c1-2-18-10-11(9-16-18)7-8-14(19)17-13-6-4-3-5-12(13)15/h3-10H,2,15H2,1H3,(H,17,19)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375770
PNG
(US9908899, Compound F4)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CC2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H26N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-12,14,20,28H,13,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375771
PNG
(US9908899, Compound F5)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)c(Cl)c1
Show InChI InChI=1S/C26H23ClN4O/c27-22-13-21(26(32)30-24-4-2-1-3-23(24)28)8-7-20(22)11-18-15-31(16-18)14-17-5-6-19-9-10-29-25(19)12-17/h1-13,29H,14-16,28H2,(H,30,32)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375773
PNG
(US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375774
PNG
(US9908899, Compound G1)
Show SMILES CN1CCC(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)CC1
Show InChI InChI=1S/C19H25N5O/c1-23-10-8-15(9-11-23)13-24-14-16(12-21-24)6-7-19(25)22-18-5-3-2-4-17(18)20/h2-7,12,14-15H,8-11,13,20H2,1H3,(H,22,25)/b7-6+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375734
PNG
(US9908899, Compound B4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375737
PNG
(US9908899, Compound B5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(Cl)c2)c1
Show InChI InChI=1S/C20H18ClFN4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375739
PNG
(US9908899, Compound D4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C19H18N4O/c20-17-8-4-5-9-18(17)22-19(24)11-10-16-12-21-23(14-16)13-15-6-2-1-3-7-15/h1-12,14H,13,20H2,(H,22,24)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375744
PNG
(US9908899, Compound D5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17FN4O/c20-16-8-5-14(6-9-16)12-24-13-15(11-22-24)7-10-19(25)23-18-4-2-1-3-17(18)21/h1-11,13H,12,21H2,(H,23,25)/b10-7+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375744
PNG
(US9908899, Compound D5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17FN4O/c20-16-8-5-14(6-9-16)12-24-13-15(11-22-24)7-10-19(25)23-18-4-2-1-3-17(18)21/h1-11,13H,12,21H2,(H,23,25)/b10-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375745
PNG
(US9908899, Compound D12)
Show SMILES CN(CCCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1)c1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-26(19-8-3-2-4-9-19)14-7-15-27-17-18(16-24-27)12-13-22(28)25-21-11-6-5-10-20(21)23/h2-6,8-13,16-17H,7,14-15,23H2,1H3,(H,25,28)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375749
PNG
(US9908899, Compound D6)
Show SMILES Cc1cccc(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)n1
Show InChI InChI=1S/C19H19N5O/c1-14-5-4-6-16(22-14)13-24-12-15(11-21-24)9-10-19(25)23-18-8-3-2-7-17(18)20/h2-12H,13,20H2,1H3,(H,23,25)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375758
PNG
(US9908899, Compound C3)
Show SMILES Cn1cc(\C=C\C(=O)Nc2cc(F)ccc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-6-10(14)3-4-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375766
PNG
((E)-N-(2-aminophenyl)-3-(2-cinnamylthiazol-4-yl)ac...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1csc(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C21H19N3OS/c22-18-10-4-5-11-19(18)24-20(25)14-13-17-15-26-21(23-17)12-6-9-16-7-2-1-3-8-16/h1-11,13-15H,12,22H2,(H,24,25)/b9-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375768
PNG
(US9908899, Compound F2)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C25H26N4O/c26-23-5-1-2-6-24(23)28-25(30)22-9-7-19(8-10-22)16-20-11-14-29(15-12-20)18-21-4-3-13-27-17-21/h1-10,13,16-17H,11-12,14-15,18,26H2,(H,28,30)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375769
PNG
(US9908899, Compound F3)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H24N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-14,28H,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375769
PNG
(US9908899, Compound F3)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H24N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-14,28H,15-17,27H2,(H,29,31)
PDB

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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375764
PNG
(US9908899, Compound A4)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)co1
Show InChI InChI=1S/C13H13N3O2/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375764
PNG
(US9908899, Compound A4)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)co1
Show InChI InChI=1S/C13H13N3O2/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375757
PNG
(US9908899, Compound C2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccc(F)cc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-4-3-10(14)6-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375757
PNG
(US9908899, Compound C2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccc(F)cc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-4-3-10(14)6-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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n/an/a>2.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375753
PNG
(US9908899, Compound A10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccnc2s1
Show InChI InChI=1S/C14H12N4OS/c15-11-3-1-2-4-12(11)17-13(19)6-5-10-9-18-8-7-16-14(18)20-10/h1-9H,15H2,(H,17,19)/b6-5+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375774
PNG
(US9908899, Compound G1)
Show SMILES CN1CCC(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)CC1
Show InChI InChI=1S/C19H25N5O/c1-23-10-8-15(9-11-23)13-24-14-16(12-21-24)6-7-19(25)22-18-5-3-2-4-17(18)20/h2-7,12,14-15H,8-11,13,20H2,1H3,(H,22,25)/b7-6+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375758
PNG
(US9908899, Compound C3)
Show SMILES Cn1cc(\C=C\C(=O)Nc2cc(F)ccc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-6-10(14)3-4-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375760
PNG
(US9908899, Compound C1)
Show SMILES CCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C14H16N4O/c1-2-18-10-11(9-16-18)7-8-14(19)17-13-6-4-3-5-12(13)15/h3-10H,2,15H2,1H3,(H,17,19)/b8-7+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375756
PNG
(US9908899, Compound A7)
Show SMILES Cn1ccc(\C=C\C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C13H14N4O/c1-17-9-8-10(16-17)6-7-13(18)15-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,15,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375756
PNG
(US9908899, Compound A7)
Show SMILES Cn1ccc(\C=C\C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C13H14N4O/c1-17-9-8-10(16-17)6-7-13(18)15-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,15,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375759
PNG
(US9908899, Compound A11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c19-16-8-4-5-9-17(16)21-18(23)11-10-14-12-20-22(13-14)15-6-2-1-3-7-15/h1-13H,19H2,(H,21,23)/b11-10+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375757
PNG
(US9908899, Compound C2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccc(F)cc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-4-3-10(14)6-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375767
PNG
(US9908899, Compound F1)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC2)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C27H27N3O3/c28-24-8-4-5-9-25(24)29-26(31)23-12-10-20(11-13-23)18-21-14-16-30(17-15-21)27(32)33-19-22-6-2-1-3-7-22/h1-13,18H,14-17,19,28H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375736
PNG
(US9908899, Compound D16)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-7-8-19(18(22)12-16)24-20(26)9-6-15-13-23-25(14-15)10-11-27-17-4-2-1-3-5-17/h1-9,12-14H,10-11,22H2,(H,24,26)/b9-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375749
PNG
(US9908899, Compound D6)
Show SMILES Cc1cccc(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)n1
Show InChI InChI=1S/C19H19N5O/c1-14-5-4-6-16(22-14)13-24-12-15(11-21-24)9-10-19(25)23-18-8-3-2-7-17(18)20/h2-12H,13,20H2,1H3,(H,23,25)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375766
PNG
((E)-N-(2-aminophenyl)-3-(2-cinnamylthiazol-4-yl)ac...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1csc(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C21H19N3OS/c22-18-10-4-5-11-19(18)24-20(25)14-13-17-15-26-21(23-17)12-6-9-16-7-2-1-3-8-16/h1-11,13-15H,12,22H2,(H,24,25)/b9-6+,14-13+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375753
PNG
(US9908899, Compound A10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccnc2s1
Show InChI InChI=1S/C14H12N4OS/c15-11-3-1-2-4-12(11)17-13(19)6-5-10-9-18-8-7-16-14(18)20-10/h1-9H,15H2,(H,17,19)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375760
PNG
(US9908899, Compound C1)
Show SMILES CCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C14H16N4O/c1-2-18-10-11(9-16-18)7-8-14(19)17-13-6-4-3-5-12(13)15/h3-10H,2,15H2,1H3,(H,17,19)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375761
PNG
(US9908899, Compound B1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC2CC2)c1
Show InChI InChI=1S/C16H18N4O/c17-14-3-1-2-4-15(14)19-16(21)8-7-13-9-18-20(11-13)10-12-5-6-12/h1-4,7-9,11-12H,5-6,10,17H2,(H,19,21)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50254780
PNG
(CHEMBL4078477 | US9908899, Compound D2)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375772
PNG
(US9908899, Compound F6)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)c(Cl)c1
Show InChI InChI=1S/C23H21ClN4O/c24-20-11-19(23(29)27-22-6-2-1-5-21(22)25)8-7-18(20)10-17-14-28(15-17)13-16-4-3-9-26-12-16/h1-12H,13-15,25H2,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375748
PNG
(US9908899, Compound D10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC(F)(F)c2ccccc2)c1
Show InChI InChI=1S/C20H18F2N4O/c21-20(22,16-6-2-1-3-7-16)14-26-13-15(12-24-26)10-11-19(27)25-18-9-5-4-8-17(18)23/h1-13H,14,23H2,(H,25,27)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375752
PNG
(US9908899, Compound A9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccccc2n1
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-20-10-4-3-7-15(20)18-12/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375775
PNG
(US9908899, Compound G2)
Show SMILES Cc1nn(C\C=C\c2ccccc2)c(C)c1\C=C\C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H24N4O/c1-17-20(14-15-23(28)25-22-13-7-6-12-21(22)24)18(2)27(26-17)16-8-11-19-9-4-3-5-10-19/h3-15H,16,24H2,1-2H3,(H,25,28)/b11-8+,15-14+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375762
PNG
(US9908899, Compound A1)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)cs1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375764
PNG
(US9908899, Compound A4)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)co1
Show InChI InChI=1S/C13H13N3O2/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375774
PNG
(US9908899, Compound G1)
Show SMILES CN1CCC(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)CC1
Show InChI InChI=1S/C19H25N5O/c1-23-10-8-15(9-11-23)13-24-14-16(12-21-24)6-7-19(25)22-18-5-3-2-4-17(18)20/h2-7,12,14-15H,8-11,13,20H2,1H3,(H,22,25)/b7-6+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375775
PNG
(US9908899, Compound G2)
Show SMILES Cc1nn(C\C=C\c2ccccc2)c(C)c1\C=C\C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H24N4O/c1-17-20(14-15-23(28)25-22-13-7-6-12-21(22)24)18(2)27(26-17)16-8-11-19-9-4-3-5-10-19/h3-15H,16,24H2,1-2H3,(H,25,28)/b11-8+,15-14+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375734
PNG
(US9908899, Compound B4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375740
PNG
(US9908899, Compound D7)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O/c21-18-8-4-5-9-19(18)23-20(25)11-10-17-14-22-24(15-17)13-12-16-6-2-1-3-7-16/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375749
PNG
(US9908899, Compound D6)
Show SMILES Cc1cccc(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)n1
Show InChI InChI=1S/C19H19N5O/c1-14-5-4-6-16(22-14)13-24-12-15(11-21-24)9-10-19(25)23-18-8-3-2-7-17(18)20/h2-12H,13,20H2,1H3,(H,23,25)/b10-9+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375752
PNG
(US9908899, Compound A9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccccc2n1
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-20-10-4-3-7-15(20)18-12/h1-11H,17H2,(H,19,21)/b9-8+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375758
PNG
(US9908899, Compound C3)
Show SMILES Cn1cc(\C=C\C(=O)Nc2cc(F)ccc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-6-10(14)3-4-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375771
PNG
(US9908899, Compound F5)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)c(Cl)c1
Show InChI InChI=1S/C26H23ClN4O/c27-22-13-21(26(32)30-24-4-2-1-3-23(24)28)8-7-20(22)11-18-15-31(16-18)14-17-5-6-19-9-10-29-25(19)12-17/h1-13,29H,14-16,28H2,(H,30,32)
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50254780
PNG
(CHEMBL4078477 | US9908899, Compound D2)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
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US Patent
n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375733
PNG
(US9908899, Compound B2)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccc(F)cc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-10-7-16(8-11-18)4-3-13-26-15-17(14-24-26)9-12-21(27)25-20-6-2-1-5-19(20)23/h1-12,14-15H,13,23H2,(H,25,27)/b4-3+,12-9+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375738
PNG
(US9908899, Compound A12)
Show SMILES Cn1cnc(\C=C\C(=O)Nc2ccccc2N)c1
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(15-9-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375744
PNG
(US9908899, Compound D5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17FN4O/c20-16-8-5-14(6-9-16)12-24-13-15(11-22-24)7-10-19(25)23-18-4-2-1-3-17(18)21/h1-11,13H,12,21H2,(H,23,25)/b10-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375736
PNG
(US9908899, Compound D16)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-7-8-19(18(22)12-16)24-20(26)9-6-15-13-23-25(14-15)10-11-27-17-4-2-1-3-5-17/h1-9,12-14H,10-11,22H2,(H,24,26)/b9-6+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375739
PNG
(US9908899, Compound D4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C19H18N4O/c20-17-8-4-5-9-18(17)22-19(24)11-10-16-12-21-23(14-16)13-15-6-2-1-3-7-15/h1-12,14H,13,20H2,(H,22,24)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375754
PNG
((E)-N-(2-aminophenyl)-3-(6-(ethoxymethyl)imidazo[2...)
Show SMILES CCOCc1cn2cc(\C=C\C(=O)Nc3ccccc3N)sc2n1
Show InChI InChI=1S/C17H18N4O2S/c1-2-23-11-12-9-21-10-13(24-17(21)19-12)7-8-16(22)20-15-6-4-3-5-14(15)18/h3-10H,2,11,18H2,1H3,(H,20,22)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375759
PNG
(US9908899, Compound A11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c19-16-8-4-5-9-17(16)21-18(23)11-10-14-12-20-22(13-14)15-6-2-1-3-7-15/h1-13H,19H2,(H,21,23)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375751
PNG
(US9908899, Compound A8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cc2ccccn2n1
Show InChI InChI=1S/C16H14N4O/c17-14-6-1-2-7-15(14)18-16(21)9-8-12-11-13-5-3-4-10-20(13)19-12/h1-11H,17H2,(H,18,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375755
PNG
(US9908899, Compound A2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C13H14N4O/c1-17-9-10(8-15-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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n/an/a 7.50E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375754
PNG
((E)-N-(2-aminophenyl)-3-(6-(ethoxymethyl)imidazo[2...)
Show SMILES CCOCc1cn2cc(\C=C\C(=O)Nc3ccccc3N)sc2n1
Show InChI InChI=1S/C17H18N4O2S/c1-2-23-11-12-9-21-10-13(24-17(21)19-12)7-8-16(22)20-15-6-4-3-5-14(15)18/h3-10H,2,11,18H2,1H3,(H,20,22)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375750
PNG
(US9908899, Compound A6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnc2ccccn12
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-18-15-7-3-4-10-20(12)15/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375738
PNG
(US9908899, Compound A12)
Show SMILES Cn1cnc(\C=C\C(=O)Nc2ccccc2N)c1
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(15-9-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375750
PNG
(US9908899, Compound A6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnc2ccccn12
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-18-15-7-3-4-10-20(12)15/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375763
PNG
(US9908899, Compound A3)
Show SMILES Cc1ncc(\C=C\C(=O)Nc2ccccc2N)s1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-8-10(18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375763
PNG
(US9908899, Compound A3)
Show SMILES Cc1ncc(\C=C\C(=O)Nc2ccccc2N)s1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-8-10(18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375762
PNG
(US9908899, Compound A1)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)cs1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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MMDB

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n/an/a 7.50E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375761
PNG
(US9908899, Compound B1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC2CC2)c1
Show InChI InChI=1S/C16H18N4O/c17-14-3-1-2-4-15(14)19-16(21)8-7-13-9-18-20(11-13)10-12-5-6-12/h1-4,7-9,11-12H,5-6,10,17H2,(H,19,21)/b8-7+
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n/an/a 7.50E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375765
PNG
(US9908899, Compound A5)
Show SMILES Cc1cc(\C=C\C(=O)Nc2ccccc2N)on1
Show InChI InChI=1S/C13H13N3O2/c1-9-8-10(18-16-9)6-7-13(17)15-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,15,17)/b7-6+
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n/an/a 1.50E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375765
PNG
(US9908899, Compound A5)
Show SMILES Cc1cc(\C=C\C(=O)Nc2ccccc2N)on1
Show InChI InChI=1S/C13H13N3O2/c1-9-8-10(18-16-9)6-7-13(17)15-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,15,17)/b7-6+
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n/an/a 1.50E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375755
PNG
(US9908899, Compound A2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C13H14N4O/c1-17-9-10(8-15-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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n/an/a 1.50E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US9908899 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%