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Patent code US9914707

Compile Data Set for Download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM375780
PNG
(US9914707, I-5)
Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C29H23N5O2S/c30-28-26-25(17-37-27(26)24(15-31-28)20-14-32-34(16-20)11-12-35)19-9-10-22-18(13-19)5-4-8-23(22)29(36)33-21-6-2-1-3-7-21/h1-10,13-17,35H,11-12H2,(H2,30,31)(H,33,36)
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US Patent
n/an/a 1.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020167
PNG
(CHEMBL3288518 | US9914707, I-17)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c12
Show InChI InChI=1S/C24H16Cl2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 1.40n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526 | US9914707, I-4)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a 1.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020170
PNG
(CHEMBL3288502 | US9914707, I-1)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H18N4O/c25-23-22-19(9-5-11-21(22)27-28-23)16-12-13-18-15(14-16)6-4-10-20(18)24(29)26-17-7-2-1-3-8-17/h1-14H,(H,26,29)(H3,25,27,28)
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n/an/a 1.60n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020166
PNG
(CHEMBL3288505 | US9914707, I-8)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C25H20N4O/c1-15-8-11-18(12-9-15)27-25(30)21-6-2-4-16-14-17(10-13-19(16)21)20-5-3-7-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 1.90n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020210
PNG
(CHEMBL3288519 | US9914707, I-18)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Br)cc(Br)c3)c12
Show InChI InChI=1S/C24H16Br2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 2.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020229
PNG
(CHEMBL3288508 | US9914707, I-20)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-20(26)22(12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-21-23(18)24(27)30-29-21/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 3.80n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020233
PNG
(CHEMBL3288510 | US9914707, I-23)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1F
Show InChI InChI=1S/C25H19FN4O/c1-14-8-10-17(13-21(14)26)28-25(31)20-6-2-4-15-12-16(9-11-18(15)20)19-5-3-7-22-23(19)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 4.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM375725
PNG
(US9914707, ABT869)
Show SMILES Cc1ccc(F)c(c1)N(C(N)=O)c1ccc(cc1)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)27(21(24)28)14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)26-25-17/h2-11H,1H3,(H2,24,28)(H3,23,25,26)
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n/an/a 6.20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020236
PNG
(CHEMBL3288524 | US9914707, I-2)
Show SMILES Nc1nccc2occ(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H17N3O2/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)
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n/an/a 7n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020195
PNG
(CHEMBL3288512 | US9914707, I-11)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c12
Show InChI InChI=1S/C24H17FN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 7.10n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020239
PNG
(CHEMBL3288525 | US9914707, I-3)
Show SMILES Nc1nccc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H17N3OS/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)
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n/an/a 7.10n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020194
PNG
(CHEMBL3288504 | US9914707, I-7)
Show SMILES Cc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C25H20N4O/c1-15-5-2-7-18(13-15)27-25(30)21-9-3-6-16-14-17(11-12-19(16)21)20-8-4-10-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 7.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020242
PNG
(CHEMBL3288507 | US9914707, I-19)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12
Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)16-5-2-6-17(13-16)30-24(33)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(29)32-31-21/h1-13H,(H,30,33)(H3,29,31,32)
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n/an/a 7.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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n/an/a 7.40n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020228
PNG
(CHEMBL3288509 | US9914707, I-22)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c(F)c1
Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-21(20(26)12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-22-23(18)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 7.60n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM375796
PNG
(US9914707, I-21)
Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C25H19FN4O/c1-14-12-17(9-11-21(14)26)28-25(31)20-6-2-4-15-13-16(8-10-18(15)20)19-5-3-7-22-23(19)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 8.10n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM375803
PNG
(US9914707, I-28)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3F)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H17FN4O/c25-22-17-9-4-10-19(24(30)27-14-6-2-1-3-7-14)15(17)12-13-18(22)16-8-5-11-20-21(16)23(26)29-28-20/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 8.60n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020245
PNG
(CHEMBL3288513 | US9914707, I-12)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C24H17FN4O/c25-16-8-10-17(11-9-16)27-24(30)20-5-1-3-14-13-15(7-12-18(14)20)19-4-2-6-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 9.20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020234
PNG
(CHEMBL3288520 | US9914707, I-24)
Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1
Show InChI InChI=1S/C22H17N5O2/c1-12-10-19(27-29-12)24-22(28)17-6-2-4-13-11-14(8-9-15(13)17)16-5-3-7-18-20(16)21(23)26-25-18/h2-11H,1H3,(H3,23,25,26)(H,24,27,28)
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n/an/a 9.70n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020193
PNG
(CHEMBL3288515 | US9914707, I-14)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(F)cc(F)c3)c12
Show InChI InChI=1S/C24H16F2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 10.8n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020169
PNG
(CHEMBL3288506 | US9914707, I-9)
Show SMILES CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C26H22N4O/c1-2-16-6-3-8-19(14-16)28-26(31)22-10-4-7-17-15-18(12-13-20(17)22)21-9-5-11-23-24(21)25(27)30-29-23/h3-15H,2H2,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 18.2n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020235
PNG
(CHEMBL3288511 | US9914707, I-10)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3F)c12
Show InChI InChI=1S/C24H17FN4O/c25-19-8-1-2-9-20(19)27-24(30)18-7-3-5-14-13-15(11-12-16(14)18)17-6-4-10-21-22(17)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 18.7n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020246
PNG
(CHEMBL3288521 | US9914707, I-25)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c12
Show InChI InChI=1S/C23H17N5O/c24-22-21-18(6-2-8-20(21)27-28-22)15-9-10-17-14(12-15)4-1-7-19(17)23(29)26-16-5-3-11-25-13-16/h1-13H,(H,26,29)(H3,24,27,28)
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n/an/a 20.2n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020230
PNG
(CHEMBL3288517 | US9914707, I-16)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Br)c3)c12
Show InChI InChI=1S/C24H17BrN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 24n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020248
PNG
(CHEMBL3288503 | US9914707, I-6)
Show SMILES Cc1ccccc1NC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C25H20N4O/c1-15-6-2-3-10-21(15)27-25(30)20-9-4-7-16-14-17(12-13-18(16)20)19-8-5-11-22-23(19)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 26.7n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020227
PNG
(CHEMBL3288516 | US9914707, I-15)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C24H17ClN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 48.4n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020223
PNG
(CHEMBL3288514 | US9914707, I-13)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3F)c12
Show InChI InChI=1S/C24H16F2N4O/c25-15-8-10-20(19(26)12-15)28-24(31)18-5-1-3-13-11-14(7-9-16(13)18)17-4-2-6-21-22(17)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 92.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020225
PNG
(CHEMBL3288523 | US9914707, I-27)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12
Show InChI InChI=1S/C21H18N4O/c22-20-19-16(4-2-6-18(19)24-25-20)13-7-10-15-12(11-13)3-1-5-17(15)21(26)23-14-8-9-14/h1-7,10-11,14H,8-9H2,(H,23,26)(H3,22,24,25)
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US Patent
n/an/a 95.2n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50020238
PNG
(CHEMBL3288522 | US9914707, I-26)
Show SMILES CCNC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C20H18N4O/c1-2-22-20(25)16-7-3-5-12-11-13(9-10-14(12)16)15-6-4-8-17-18(15)19(21)24-23-17/h3-11H,2H2,1H3,(H,22,25)(H3,21,23,24)
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n/an/a 101n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...


US Patent US9914707 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%