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Patent code US9914731

Compile Data Set for Download or QSAR

Found 293 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375874
PNG
(US9914731, Ex. No. 94)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H25F2N7O4/c1-18(2)38-15-23(30(42)40(31(38)43)22-7-4-20(32)5-8-22)29(41)36-21-6-9-27(24(33)13-21)44-28-12-19(25-16-37(3)17-34-25)14-39-26(28)10-11-35-39/h4-18H,1-3H3,(H,36,41)
PDB

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US Patent
n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375881
PNG
(US9914731, Ex. No. 101)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cscn3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H20F2N6O4S/c1-2-35-14-21(28(39)37(29(35)40)20-6-3-18(30)4-7-20)27(38)34-19-5-8-25(22(31)12-19)41-26-11-17(23-15-42-16-32-23)13-36-24(26)9-10-33-36/h3-16H,2H2,1H3,(H,34,38)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375885
PNG
(US9914731, Ex. No. 104)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cncs3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H20F2N6O4S/c1-2-35-15-21(28(39)37(29(35)40)20-6-3-18(30)4-7-20)27(38)34-19-5-8-24(22(31)12-19)41-25-11-17(26-13-32-16-42-26)14-36-23(25)9-10-33-36/h3-16H,2H2,1H3,(H,34,38)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375894
PNG
(US9914731, Ex. No. 113)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H24FN7O4/c1-3-36-16-24(29(40)38(30(36)41)22-8-4-20(31)5-9-22)28(39)34-21-6-10-23(11-7-21)42-27-14-19(25-17-35(2)18-32-25)15-37-26(27)12-13-33-37/h4-18H,3H2,1-2H3,(H,34,39)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375920
PNG
(US9914731, Ex. No. 139)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)C(=O)N(C)C)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H24F2N6O5/c1-4-35-16-21(28(40)37(29(35)41)20-8-5-18(30)6-9-20)26(38)33-19-7-10-24(22(31)14-19)42-25-13-17(27(39)34(2)3)15-36-23(25)11-12-32-36/h5-16H,4H2,1-3H3,(H,33,38)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375905
PNG
(US9914731, Ex. No. 124)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)cn2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H25FN8O4/c1-18(2)37-15-23(29(41)39(30(37)42)21-6-4-20(31)5-7-21)28(40)35-27-9-8-22(13-32-27)43-26-12-19(24-16-36(3)17-33-24)14-38-25(26)10-11-34-38/h4-18H,1-3H3,(H,32,35,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375895
PNG
(US9914731, Ex. No. 114)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H26FN7O4/c1-19(2)37-16-25(30(41)39(31(37)42)23-8-4-21(32)5-9-23)29(40)35-22-6-10-24(11-7-22)43-28-14-20(26-17-36(3)18-33-26)15-38-27(28)12-13-34-38/h4-19H,1-3H3,(H,35,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375895
PNG
(US9914731, Ex. No. 114)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H26FN7O4/c1-19(2)37-16-25(30(41)39(31(37)42)23-8-4-21(32)5-9-23)29(40)35-22-6-10-24(11-7-22)43-28-14-20(26-17-36(3)18-33-26)15-38-27(28)12-13-34-38/h4-19H,1-3H3,(H,35,40)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375781
PNG
(US9914731, Ex. No. 5)
Show SMILES Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(Oc3cccn4nccc34)c(F)c2)cc1
Show InChI InChI=1S/C24H18F2N4O3/c25-15-3-5-16(6-4-15)28-22(31)24(10-11-24)23(32)29-17-7-8-20(18(26)14-17)33-21-2-1-13-30-19(21)9-12-27-30/h1-9,12-14H,10-11H2,(H,28,31)(H,29,32)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375820
PNG
(US9914731, Ex. No. 42)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn[nH]c3)c(F)c2)c1=O
Show InChI InChI=1S/C28H18F2N6O3/c29-19-3-6-21(7-4-19)35-11-1-2-22(28(35)38)27(37)34-20-5-8-25(23(30)13-20)39-26-12-17(18-14-31-32-15-18)16-36-24(26)9-10-33-36/h1-16H,(H,31,32)(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375812
PNG
(US9914731, Ex. No. 34)
Show SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cnn(C)c3)c(F)c2)c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H22F2N6O3/c1-18-3-9-24(30(40)38(18)23-7-4-21(31)5-8-23)29(39)35-22-6-10-27(25(32)14-22)41-28-13-19(20-15-34-36(2)16-20)17-37-26(28)11-12-33-37/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375817
PNG
(US9914731, Ex. No. 39)
Show SMILES Cc1c(cnn1C)-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C30H22F2N6O3/c1-18-24(16-34-36(18)2)19-14-28(26-11-12-33-38(26)17-19)41-27-10-7-21(15-25(27)32)35-29(39)23-4-3-13-37(30(23)40)22-8-5-20(31)6-9-22/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375817
PNG
(US9914731, Ex. No. 39)
Show SMILES Cc1c(cnn1C)-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C30H22F2N6O3/c1-18-24(16-34-36(18)2)19-14-28(26-11-12-33-38(26)17-19)41-27-10-7-21(15-25(27)32)35-29(39)23-4-3-13-37(30(23)40)22-8-5-20(31)6-9-22/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375826
PNG
(US9914731, Ex. No. 48)
Show SMILES Cc1noc(C)c1-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C30H21F2N5O4/c1-17-28(18(2)41-35-17)19-14-27(25-11-12-33-37(25)16-19)40-26-10-7-21(15-24(26)32)34-29(38)23-4-3-13-36(30(23)39)22-8-5-20(31)6-9-22/h3-16H,1-2H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375830
PNG
(US9914731, Ex. No. 52)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cnco3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H20F2N6O5/c1-2-35-15-21(28(39)37(29(35)40)20-6-3-18(30)4-7-20)27(38)34-19-5-8-24(22(31)12-19)42-25-11-17(26-13-32-16-41-26)14-36-23(25)9-10-33-36/h3-16H,2H2,1H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375832
PNG
(US9914731, Ex. No. 54)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cnsc3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H20F2N6O4S/c1-2-35-15-22(28(39)37(29(35)40)21-6-3-19(30)4-7-21)27(38)34-20-5-8-25(23(31)12-20)41-26-11-17(18-13-33-42-16-18)14-36-24(26)9-10-32-36/h3-16H,2H2,1H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375844
PNG
(US9914731, Ex. No. 66)
Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2cc(cn3nccc23)N2CCOCC2)c(F)c1
Show InChI InChI=1S/C31H27F2N5O5/c1-2-42-27-10-12-37(22-6-3-20(32)4-7-22)31(40)29(27)30(39)35-21-5-8-26(24(33)17-21)43-28-18-23(36-13-15-41-16-14-36)19-38-25(28)9-11-34-38/h3-12,17-19H,2,13-16H2,1H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375859
PNG
(US9914731, Ex. No. 80)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(Nc4ccccc4)cn4nccc34)c(F)c2)c1=O
Show InChI InChI=1S/C31H21F2N5O3/c32-20-8-11-24(12-9-20)37-16-4-7-25(31(37)40)30(39)36-22-10-13-28(26(33)17-22)41-29-18-23(19-38-27(29)14-15-34-38)35-21-5-2-1-3-6-21/h1-19,35H,(H,36,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375867
PNG
(US9914731, Ex. No. 88)
Show SMILES Cn1cnc(c1)-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C29H20F2N6O3/c1-35-16-24(32-17-35)18-13-27(25-10-11-33-37(25)15-18)40-26-9-6-20(14-23(26)31)34-28(38)22-3-2-12-36(29(22)39)21-7-4-19(30)5-8-21/h2-17H,1H3,(H,34,38)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375872
PNG
(US9914731, Ex. No. 92)
Show SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cncn3C)c(F)c2)c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H22F2N6O3/c1-18-3-9-23(30(40)38(18)22-7-4-20(31)5-8-22)29(39)35-21-6-10-27(24(32)14-21)41-28-13-19(26-15-33-17-36(26)2)16-37-25(28)11-12-34-37/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375887
PNG
(US9914731, Ex. No. 106)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cscn3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H22F2N6O4S/c1-17(2)36-14-22(29(40)38(30(36)41)21-6-3-19(31)4-7-21)28(39)35-20-5-8-26(23(32)12-20)42-27-11-18(24-15-43-16-33-24)13-37-25(27)9-10-34-37/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375899
PNG
(US9914731, Ex. No. 118)
Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2cc(cn3nccc23)-c2cn(C)cn2)cc1
Show InChI InChI=1S/C31H25FN6O4/c1-3-41-27-13-15-37(23-8-4-21(32)5-9-23)31(40)29(27)30(39)35-22-6-10-24(11-7-22)42-28-16-20(25-18-36(2)19-33-25)17-38-26(28)12-14-34-38/h4-19H,3H2,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375923
PNG
(US9914731, Ex. No. 142)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(NC(C)=O)cn4nccc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C28H22F2N6O5/c1-3-34-15-21(27(39)36(28(34)40)20-7-4-17(29)5-8-20)26(38)33-18-6-9-24(22(30)12-18)41-25-13-19(32-16(2)37)14-35-23(25)10-11-31-35/h4-15H,3H2,1-2H3,(H,32,37)(H,33,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375909
PNG
(US9914731, Ex. No. 128)
Show SMILES CCn1nc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H22F2N8O4/c1-3-37-29(42)39(20-7-4-18(30)5-8-20)28(41)26(35-37)27(40)34-19-6-9-24(21(31)13-19)43-25-12-17(22-15-36(2)16-32-22)14-38-23(25)10-11-33-38/h4-16H,3H2,1-2H3,(H,34,40)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375912
PNG
(US9914731, Ex. No. 131)
Show SMILES CC(C)n1nc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)cn2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H24FN9O4/c1-17(2)39-29(42)38(20-6-4-19(30)5-7-20)28(41)26(35-39)27(40)34-25-9-8-21(13-31-25)43-24-12-18(22-15-36(3)16-32-22)14-37-23(24)10-11-33-37/h4-17H,1-3H3,(H,31,34,40)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375928
PNG
(US9914731, Ex. No. 147)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N(C)C)cn4nccc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H27F2N7O5/c1-17(2)37-16-22(28(41)39(30(37)43)21-8-5-18(31)6-9-21)27(40)34-19-7-10-25(23(32)13-19)44-26-14-20(35-29(42)36(3)4)15-38-24(26)11-12-33-38/h5-17H,1-4H3,(H,34,40)(H,35,42)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375928
PNG
(US9914731, Ex. No. 147)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N(C)C)cn4nccc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H27F2N7O5/c1-17(2)37-16-22(28(41)39(30(37)43)21-8-5-18(31)6-9-21)27(40)34-19-7-10-25(23(32)13-19)44-26-14-20(35-29(42)36(3)4)15-38-24(26)11-12-33-38/h5-17H,1-4H3,(H,34,40)(H,35,42)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375804
PNG
(US9914731, Ex. No. 26)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3ccc(nc3)N3CCOCC3)c(F)c2)c1=O
Show InChI InChI=1S/C34H26F2N6O4/c35-24-4-7-26(8-5-24)41-13-1-2-27(34(41)44)33(43)39-25-6-9-30(28(36)19-25)46-31-18-23(21-42-29(31)11-12-38-42)22-3-10-32(37-20-22)40-14-16-45-17-15-40/h1-13,18-21H,14-17H2,(H,39,43)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375807
PNG
(US9914731, Ex. No. 29)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C29H20F2N6O3/c1-35-16-19(15-33-35)18-13-27(25-10-11-32-37(25)17-18)40-26-9-6-21(14-24(26)31)34-28(38)23-3-2-12-36(29(23)39)22-7-4-20(30)5-8-22/h2-17H,1H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375802
PNG
(US9914731, Ex. No. 25)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cccnc3)c(F)c2)c1=O
Show InChI InChI=1S/C30H19F2N5O3/c31-21-5-8-23(9-6-21)36-14-2-4-24(30(36)39)29(38)35-22-7-10-27(25(32)16-22)40-28-15-20(19-3-1-12-33-17-19)18-37-26(28)11-13-34-37/h1-18H,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375820
PNG
(US9914731, Ex. No. 42)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn[nH]c3)c(F)c2)c1=O
Show InChI InChI=1S/C28H18F2N6O3/c29-19-3-6-21(7-4-19)35-11-1-2-22(28(35)38)27(37)34-20-5-8-25(23(30)13-20)39-26-12-17(18-14-31-32-15-18)16-36-24(26)9-10-33-36/h1-16H,(H,31,32)(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375822
PNG
(US9914731, Ex. No. 44)
Show SMILES Cc1[nH]ncc1-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C29H20F2N6O3/c1-17-23(15-32-35-17)18-13-27(25-10-11-33-37(25)16-18)40-26-9-6-20(14-24(26)31)34-28(38)22-3-2-12-36(29(22)39)21-7-4-19(30)5-8-21/h2-16H,1H3,(H,32,35)(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375812
PNG
(US9914731, Ex. No. 34)
Show SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cnn(C)c3)c(F)c2)c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H22F2N6O3/c1-18-3-9-24(30(40)38(18)23-7-4-21(31)5-8-23)29(39)35-22-6-10-27(25(32)14-22)41-28-13-19(20-15-34-36(2)16-20)17-37-26(28)11-12-33-37/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375839
PNG
(US9914731, Ex. No. 61)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)N3CCOCC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H26F2N6O5/c1-2-35-18-23(29(40)38(30(35)41)21-6-3-19(31)4-7-21)28(39)34-20-5-8-26(24(32)15-20)43-27-16-22(36-11-13-42-14-12-36)17-37-25(27)9-10-33-37/h3-10,15-18H,2,11-14H2,1H3,(H,34,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375867
PNG
(US9914731, Ex. No. 88)
Show SMILES Cn1cnc(c1)-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C29H20F2N6O3/c1-35-16-24(32-17-35)18-13-27(25-10-11-33-37(25)15-18)40-26-9-6-20(14-23(26)31)34-28(38)22-3-2-12-36(29(22)39)21-7-4-19(30)5-8-21/h2-17H,1H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375869
PNG
(US9914731, Ex. No. 89)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cn2)c2ccnn2c1
Show InChI InChI=1S/C28H20FN7O3/c1-34-16-19(14-32-34)18-13-25(24-10-11-31-36(24)17-18)39-26-9-6-21(15-30-26)33-27(37)23-3-2-12-35(28(23)38)22-7-4-20(29)5-8-22/h2-17H,1H3,(H,33,37)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375879
PNG
(US9914731, Ex. No. 99)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3ncco3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H22F2N6O5/c1-17(2)36-16-22(29(40)38(30(36)41)21-6-3-19(31)4-7-21)27(39)35-20-5-8-25(23(32)14-20)43-26-13-18(28-33-11-12-42-28)15-37-24(26)9-10-34-37/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375871
PNG
(US9914731, Ex. No. 91)
Show SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)c(F)c2)c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H22F2N6O3/c1-18-3-9-23(30(40)38(18)22-7-4-20(31)5-8-22)29(39)35-21-6-10-27(24(32)14-21)41-28-13-19(25-16-36(2)17-33-25)15-37-26(28)11-12-34-37/h3-17H,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375873
PNG
(US9914731, Ex. No. 93)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O4/c1-3-37-15-22(29(41)39(30(37)42)21-7-4-19(31)5-8-21)28(40)35-20-6-9-26(23(32)13-20)43-27-12-18(24-16-36(2)17-33-24)14-38-25(27)10-11-34-38/h4-17H,3H2,1-2H3,(H,35,40)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375881
PNG
(US9914731, Ex. No. 101)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cscn3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H20F2N6O4S/c1-2-35-14-21(28(39)37(29(35)40)20-6-3-18(30)4-7-20)27(38)34-19-5-8-25(22(31)12-19)41-26-11-17(23-15-42-16-32-23)13-36-24(26)9-10-33-36/h3-16H,2H2,1H3,(H,34,38)
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Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375886
PNG
(US9914731, Ex. No. 105)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cncs3)c(F)c2)c1=O
Show InChI InChI=1S/C28H17F2N5O3S/c29-18-3-6-20(7-4-18)34-11-1-2-21(28(34)37)27(36)33-19-5-8-24(22(30)13-19)38-25-12-17(26-14-31-16-39-26)15-35-23(25)9-10-32-35/h1-16H,(H,33,36)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375906
PNG
(US9914731, Ex. No. 125)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)c(c2)C(F)(F)F)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H23F4N7O4/c1-3-40-15-22(29(44)42(30(40)45)21-7-4-19(32)5-8-21)28(43)38-20-6-9-26(23(13-20)31(33,34)35)46-27-12-18(24-16-39(2)17-36-24)14-41-25(27)10-11-37-41/h4-17H,3H2,1-2H3,(H,38,43)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375894
PNG
(US9914731, Ex. No. 113)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H24FN7O4/c1-3-36-16-24(29(40)38(30(36)41)22-8-4-20(31)5-9-22)28(39)34-21-6-10-23(11-7-21)42-27-14-19(25-17-35(2)18-32-25)15-37-26(27)12-13-33-37/h4-18H,3H2,1-2H3,(H,34,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375919
PNG
(US9914731, Ex. No. 138)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)C(=O)N(C)C)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H26F2N6O5/c1-17(2)36-16-22(29(41)38(30(36)42)21-8-5-19(31)6-9-21)27(39)34-20-7-10-25(23(32)14-20)43-26-13-18(28(40)35(3)4)15-37-24(26)11-12-33-37/h5-17H,1-4H3,(H,34,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375923
PNG
(US9914731, Ex. No. 142)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3cc(NC(C)=O)cn4nccc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C28H22F2N6O5/c1-3-34-15-21(27(39)36(28(34)40)20-7-4-17(29)5-8-20)26(38)33-18-6-9-24(22(30)12-18)41-25-13-19(32-16(2)37)14-35-23(25)10-11-31-35/h4-15H,3H2,1-2H3,(H,32,37)(H,33,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375909
PNG
(US9914731, Ex. No. 128)
Show SMILES CCn1nc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cn(C)cn3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H22F2N8O4/c1-3-37-29(42)39(20-7-4-18(30)5-8-20)28(41)26(35-37)27(40)34-19-6-9-24(21(31)13-19)43-25-12-17(22-15-36(2)16-32-22)14-38-23(25)10-11-33-38/h4-16H,3H2,1-2H3,(H,34,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375930
PNG
(US9914731, Ex. No. 149)
Show SMILES COC(=O)Nc1cc(Oc2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C29H24F2N6O6/c1-16(2)35-15-21(27(39)37(29(35)41)20-7-4-17(30)5-8-20)26(38)33-18-6-9-24(22(31)12-18)43-25-13-19(34-28(40)42-3)14-36-23(25)10-11-32-36/h4-16H,1-3H3,(H,33,38)(H,34,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375802
PNG
(US9914731, Ex. No. 25)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cccnc3)c(F)c2)c1=O
Show InChI InChI=1S/C30H19F2N5O3/c31-21-5-8-23(9-6-21)36-14-2-4-24(30(36)39)29(38)35-22-7-10-27(25(32)16-22)40-28-15-20(19-3-1-12-33-17-19)18-37-26(28)11-13-34-37/h1-18H,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375819
PNG
(US9914731, Ex. No. 41)
Show SMILES Cn1nccc1-c1cc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2ccnn2c1
Show InChI InChI=1S/C29H20F2N6O3/c1-35-24(10-12-32-35)18-15-27(25-11-13-33-37(25)17-18)40-26-9-6-20(16-23(26)31)34-28(38)22-3-2-14-36(29(22)39)21-7-4-19(30)5-8-21/h2-17H,1H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375855
PNG
(US9914731, Ex. No. 76)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)N3CCCC3=O)c(F)c2)c1=O
Show InChI InChI=1S/C29H21F2N5O4/c30-18-5-8-20(9-6-18)35-14-1-3-22(29(35)39)28(38)33-19-7-10-25(23(31)15-19)40-26-16-21(34-13-2-4-27(34)37)17-36-24(26)11-12-32-36/h1,3,5-12,14-17H,2,4,13H2,(H,33,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%