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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376441 (6-ethyl-N-[(1R)-1-(3- methoxyphenyl)ethyl]- 6H-is...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376378 (US9914740, VIII-4 | methyl 3-((6-methyl-6H- isochr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376357 ((R)-N-(1-(3- methoxyphenyl) ethyl)-6H-iso- chromen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM50089582 (CHEMBL3578250 | US9914740, I-1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376441 (6-ethyl-N-[(1R)-1-(3- methoxyphenyl)ethyl]- 6H-is...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM50089584 (CHEMBL3578252 | US9914740, VIII-15) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376375 (US9914740, VIII-1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376390 (N-(3-(((S)-1-ethylpyrrolidin- 2-yl)methylcarbamoyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376377 (US9914740, VIII-3 | US9914740, XI-20 | US9914740, ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376397 (6-cyclopropyl-N-((R)-1-(3- methoxyphenyl)ethyl)-6H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376371 (N-(3-(1- methylazetidin-3- ylcarbamoyl) benzyl)-6H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376388 (N-(3-(2-hydroxy-2- methylpropylcarbamoyl) benzyl)-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376367 (N-(3- (ethylcarbamoyl) benzyl)-6H- isochromeno [3,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376188 (N-(3-hydroxybenzyl)-5H- chromeno[3,4-c]pyridine-8-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376386 (N-(3-carbamoylbenzyl)-6- methyl-6H-isochromeno [3,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376380 (N-((R)-1-(3-methoxyphenyl) ethyl)-6-methyl-6H-isoc...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376381 (6-methyl-N-(3-(methylcarbamoyl) benzyl)-6H-isochro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376382 (N-(3-(ethylcarbamoyl) benzyl)- 6-methyl-6H- isochr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376379 (3-((6-methyl-6H-isochromeno [3,4-c]pyridine-8-carb...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376387 (N-(3-(cyclopropylcarbamoyl) benzyl)-6-methyl- 6H-i...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376499 ((R)-1-fluoro-N-(1-(3- methoxyphenyl)ethyl)-9H- pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.01 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376351 (US9914740, VI-1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376373 ((R)-N-(3- (pyrrolidin-2- ylmethyl- carbamoyl) benz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376509 (N-(3-cyanobenzyl)-1- fluoro-9H-pyrido[3,4-b] indol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376483 ((R)-N-(1-(3- methoxyphenyl)ethyl)-9H- pyrido[3,4-b...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.29 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376363 (US9914740, VII-1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.29 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376356 (N-(3-methoxy- benzyl)-6H- isochromeno[3,4-c] pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.32 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376368 (N-(3-(methyl- carbamoyl) benzyl)-6H- isochromeno [...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.34 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376456 (N-[(1S)-2-hydroxy-1- phenylethyl]-6,6- dimethyl-6H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.44 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376369 ((S)-N-(3-((1- ethylpyrrolidin- 2-yl)methyl- carbam...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376393 (6-ethyl-N-((R)-1-phenylethyl)- 6H-isochromeno[3,4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376303 (US9914740, III-3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376377 (US9914740, VIII-3 | US9914740, XI-20 | US9914740, ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.81 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376374 (N-(4-fluoro-3- (2-hydroxy- 2-methyl- propylcarbamo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.82 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376377 (US9914740, VIII-3 | US9914740, XI-20 | US9914740, ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.99 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376304 (N-(3- carbamoylbenzyl)- 5H-chromeno[3,4-c] pyridin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.24 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376365 (US9914740, VII-3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376488 ((R)-N-(1-(3- methoxyphenyl)ethyl)-9- methyl-9H-pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.32 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376414 ((R)-N-(1-(3- methoxyphenyl)ethyl)- 6H-isochromeno ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.39 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376301 (US9914740, III-1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376385 (N-((R)-1-(4-fluorophenyl) ethyl)-6-methyl-6H- isoc...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.54 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376305 (N-(3- (ethylcarbamoyl) benzyl)-5H- chromeno[3,4-c]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.54 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376370 (US9914740, VII-8 | methyl 5-((6H- isochromeno [3,4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.54 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376383 (N-(3-(cyclopropyl- methylcarbamoyl) benzyl)-6-meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.55 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376313 (N-(3- (cyclopropyl carbamoyl) benzyl)-5H-chromeno ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.58 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376515 ((R)-N-(1-(3- methoxyphenyl)ethyl)-4- methyl-9H-pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.66 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376424 ((R)-6-(2-(Dimethylamino)ethyl)-N-(1-(3-methoxyphen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.71 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376352 (US9914740, VI-2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.78 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376355 ((R)-N-(1-(2- chlorophenyl) ethyl)-6H- isochromeno[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM376517 ((R)-N-(1-(3- methoxyphenyl) ethyl) benzofuro[2,3-c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.85 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20... | US Patent US9914740 (2018) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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