BindingDB logo
myBDB logout

Patent code US9918974

Compile Data Set for Download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa658-end)


(Homo sapiens (Human))
BDBM376119
PNG
(N-(2-(dimethylamino)ethyl)-3-(2-(4-(4-ethoxy-6-oxo...)
Show SMILES CCOc1cc(=O)ncc1-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)C(=O)NCCN(C)C)c(F)c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

US Patent


Assay Description
Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...


US Patent US9918974 (2018)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (Human))
BDBM376389
PNG
(N-(3-(2-(dimethylamino)ethoxy)-5-(trifluoromethyl)...)
Show SMILES CCOc1cc(=O)ncc1-c1ccc(CC(=O)Nc2cc(OCCN(C)C)cc(c2)C(F)(F)F)c(F)c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

US Patent


Assay Description
Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...


US Patent US9918974 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%