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Patent code US9920032

Compile Data Set for Download or QSAR

Found 510 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376831
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1CCN(C[C@H]1F)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H33F2N5O2/c1-16-9-17(11-18(31)10-16)20-5-7-32-14-25(20)34-28(36)21-3-4-23(29)22-12-19(13-33-27(21)22)35-8-6-26(37-2)24(30)15-35/h3-5,7,12-14,16-18,24,26H,6,8-11,15,31H2,1-2H3,(H,34,36)/t16-,17+,18-,24+,26+/s2
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376834
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@H]1C[C@H](O)CN1c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C27H32FN5O2/c1-15-7-17(10-18(29)8-15)21-5-6-30-13-25(21)32-27(35)22-3-4-24(28)23-11-19(12-31-26(22)23)33-14-20(34)9-16(33)2/h3-6,11-13,15-18,20,34H,7-10,14,29H2,1-2H3,(H,32,35)/t15-,16-,17+,18-,20-/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376837
PNG
(Ethyl 4-(8-(4-((1R,3S,5S)-3-amino-5-methylcyclohex...)
Show SMILES CCOC(=O)N1CCN(CC1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H35FN6O3/c1-3-39-29(38)36-10-8-35(9-11-36)21-15-24-25(30)5-4-23(27(24)33-16-21)28(37)34-26-17-32-7-6-22(26)19-12-18(2)13-20(31)14-19/h4-7,15-20H,3,8-14,31H2,1-2H3,(H,34,37)/t18-,19+,20-/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376838
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C
Show InChI InChI=1/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376672
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@@H](F)C1
Show InChI InChI=1/C26H29F2N5O/c1-15-8-16(10-18(29)9-15)20-4-6-30-13-24(20)32-26(34)21-2-3-23(28)22-11-19(12-31-25(21)22)33-7-5-17(27)14-33/h2-4,6,11-13,15-18H,5,7-10,14,29H2,1H3,(H,32,34)/t15-,16+,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376674
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H](C1)C#N
Show InChI InChI=1/C27H29FN6O/c1-16-8-18(10-19(30)9-16)21-4-6-31-14-25(21)33-27(35)22-2-3-24(28)23-11-20(13-32-26(22)23)34-7-5-17(12-29)15-34/h2-4,6,11,13-14,16-19H,5,7-10,15,30H2,1H3,(H,33,35)/t16-,17-,18+,19-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376680
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)C#CC1CC1
Show InChI InChI=1/C27H27FN4O/c1-16-10-19(13-20(29)11-16)21-8-9-30-15-25(21)32-27(33)22-6-7-24(28)23-12-18(14-31-26(22)23)5-4-17-2-3-17/h6-9,12,14-17,19-20H,2-3,10-11,13,29H2,1H3,(H,32,33)/t16-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376683
PNG
(Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F
Show InChI InChI=1/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376685
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cc(O)cc1F
Show InChI InChI=1/C28H25F3N4O2/c1-14-6-15(8-17(32)7-14)19-4-5-33-13-25(19)35-28(37)20-2-3-22(29)21-9-16(12-34-27(20)21)26-23(30)10-18(36)11-24(26)31/h2-5,9-15,17,36H,6-8,32H2,1H3,(H,35,37)/t14-,15+,17-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376687
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CCN(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C25H30FN5O/c1-4-31(3)18-12-21-22(26)6-5-20(24(21)29-13-18)25(32)30-23-14-28-8-7-19(23)16-9-15(2)10-17(27)11-16/h5-8,12-17H,4,9-11,27H2,1-3H3,(H,30,32)/t15-,16+,17-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376688
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)CC(F)(F)F
Show InChI InChI=1/C25H27F4N5O/c1-14-7-15(9-16(30)8-14)18-5-6-31-12-22(18)33-24(35)19-3-4-21(26)20-10-17(11-32-23(19)20)34(2)13-25(27,28)29/h3-6,10-12,14-16H,7-9,13,30H2,1-2H3,(H,33,35)/t14-,15+,16-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376690
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)C1CCOC1
Show InChI InChI=1/C27H32FN5O2/c1-16-9-17(11-18(29)10-16)21-5-7-30-14-25(21)32-27(34)22-3-4-24(28)23-12-20(13-31-26(22)23)33(2)19-6-8-35-15-19/h3-5,7,12-14,16-19H,6,8-11,15,29H2,1-2H3,(H,32,34)/t16-,17+,18-,19?/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376691
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)C1CCC1
Show InChI InChI=1/C27H32FN5O/c1-16-10-17(12-18(29)11-16)21-8-9-30-15-25(21)32-27(34)22-6-7-24(28)23-13-20(14-31-26(22)23)33(2)19-4-3-5-19/h6-9,13-19H,3-5,10-12,29H2,1-2H3,(H,32,34)/t16-,17+,18-/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376698
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)C1CCOCC1
Show InChI InChI=1/C27H31FN4O2/c1-16-10-18(12-20(29)11-16)21-4-7-30-15-25(21)32-27(33)22-2-3-24(28)23-13-19(14-31-26(22)23)17-5-8-34-9-6-17/h2-4,7,13-18,20H,5-6,8-12,29H2,1H3,(H,32,33)/t16-,18+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376703
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC1CCC(C)N1c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O/c1-16-10-19(12-20(30)11-16)22-8-9-31-15-26(22)33-28(35)23-6-7-25(29)24-13-21(14-32-27(23)24)34-17(2)4-5-18(34)3/h6-9,13-20H,4-5,10-12,30H2,1-3H3,(H,33,35)/t16-,17?,18?,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376707
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCC(F)(F)CC1
Show InChI InChI=1/C27H30F3N5O/c1-16-10-17(12-18(31)11-16)20-4-7-32-15-24(20)34-26(36)21-2-3-23(28)22-13-19(14-33-25(21)22)35-8-5-27(29,30)6-9-35/h2-4,7,13-18H,5-6,8-12,31H2,1H3,(H,34,36)/t16-,17+,18-/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376712
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCC(CC1)C#N
Show InChI InChI=1/C28H31FN6O/c1-17-10-19(12-20(31)11-17)22-4-7-32-16-26(22)34-28(36)23-2-3-25(29)24-13-21(15-33-27(23)24)35-8-5-18(14-30)6-9-35/h2-4,7,13,15-20H,5-6,8-12,31H2,1H3,(H,34,36)/t17-,19+,20-/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376714
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COC[C@H]1CCCN1c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-17-10-18(12-19(30)11-17)22-7-8-31-15-26(22)33-28(35)23-5-6-25(29)24-13-21(14-32-27(23)24)34-9-3-4-20(34)16-36-2/h5-8,13-15,17-20H,3-4,9-12,16,30H2,1-2H3,(H,33,35)/t17-,18+,19-,20+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376719
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COCCN(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C26H32FN5O2/c1-16-10-17(12-18(28)11-16)20-6-7-29-15-24(20)31-26(33)21-4-5-23(27)22-13-19(14-30-25(21)22)32(2)8-9-34-3/h4-7,13-18H,8-12,28H2,1-3H3,(H,31,33)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376725
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CCC1CCCCN1c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O/c1-3-21-6-4-5-11-35(21)22-15-25-26(30)8-7-24(28(25)33-16-22)29(36)34-27-17-32-10-9-23(27)19-12-18(2)13-20(31)14-19/h7-10,15-21H,3-6,11-14,31H2,1-2H3,(H,34,36)/t18-,19+,20-,21?/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376733
PNG
(N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c[nH]nc1C
Show InChI InChI=1/C26H27FN6O/c1-14-7-16(9-18(28)8-14)19-5-6-29-13-24(19)32-26(34)20-3-4-23(27)21-10-17(11-30-25(20)21)22-12-31-33-15(22)2/h3-6,10-14,16,18H,7-9,28H2,1-2H3,(H,31,33)(H,32,34)/t14-,16+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376740
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1cccc2cc(cnc12)N(C)CC(F)F
Show InChI InChI=1/C25H29F2N5O/c1-15-8-17(10-18(28)9-15)20-6-7-29-13-22(20)31-25(33)21-5-3-4-16-11-19(12-30-24(16)21)32(2)14-23(26)27/h3-7,11-13,15,17-18,23H,8-10,14,28H2,1-2H3,(H,31,33)/t15-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376744
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCCCC1
Show InChI InChI=1/C28H34FN5O/c1-18-12-19(14-20(30)13-18)22-8-9-31-17-26(22)33-28(35)23-6-7-25(29)24-15-21(16-32-27(23)24)34-10-4-2-3-5-11-34/h6-9,15-20H,2-5,10-14,30H2,1H3,(H,33,35)/t18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376747
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCc2ccccc12
Show InChI InChI=1/C30H30FN5O/c1-18-12-20(14-21(32)13-18)23-8-10-33-17-27(23)35-30(37)24-6-7-26(31)25-15-22(16-34-29(24)25)36-11-9-19-4-2-3-5-28(19)36/h2-8,10,15-18,20-21H,9,11-14,32H2,1H3,(H,35,37)/t18-,20+,21-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376753
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCN(C[C@@H]1C)S(C)(=O)=O
Show InChI InChI=1/C28H35FN6O3S/c1-17-10-19(12-20(30)11-17)22-6-7-31-15-26(22)33-28(36)23-4-5-25(29)24-13-21(14-32-27(23)24)35-9-8-34(16-18(35)2)39(3,37)38/h4-7,13-15,17-20H,8-12,16,30H2,1-3H3,(H,33,36)/t17-,18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376755
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1C[C@H]2C[C@@H]1CN2S(C)(=O)=O
Show InChI InChI=1/C28H33FN6O3S/c1-16-7-17(9-18(30)8-16)22-5-6-31-13-26(22)33-28(36)23-3-4-25(29)24-11-19(12-32-27(23)24)34-14-21-10-20(34)15-35(21)39(2,37)38/h3-6,11-13,16-18,20-21H,7-10,14-15,30H2,1-2H3,(H,33,36)/t16-,17+,18-,20+,21+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376756
PNG
((S)-Methyl 4-(8-(4-((1R,3S,5S)-3-amino-5-methylcyc...)
Show SMILES COC(=O)N1CCN([C@@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H35FN6O3/c1-17-10-19(12-20(31)11-17)22-6-7-32-15-26(22)34-28(37)23-4-5-25(30)24-13-21(14-33-27(23)24)36-9-8-35(16-18(36)2)29(38)39-3/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,37)/t17-,18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376762
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(nnc12)N1CCOC[C@H]1C
Show InChI InChI=1/C26H31FN6O2/c1-15-9-17(11-18(28)10-15)19-5-6-29-13-23(19)30-26(34)20-3-4-22(27)21-12-24(31-32-25(20)21)33-7-8-35-14-16(33)2/h3-6,12-13,15-18H,7-11,14,28H2,1-2H3,(H,30,34)/t15-,16+,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376770
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COC1CCCN(CC1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-18-12-19(14-20(31)13-18)23-7-9-32-17-27(23)34-29(36)24-5-6-26(30)25-15-21(16-33-28(24)25)35-10-3-4-22(37-2)8-11-35/h5-7,9,15-20,22H,3-4,8,10-14,31H2,1-2H3,(H,34,36)/t18-,19+,20-,22?/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376775
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1C2CCCC1COC2
Show InChI InChI=1/C29H34FN5O2/c1-17-9-18(11-19(31)10-17)23-7-8-32-14-27(23)34-29(36)24-5-6-26(30)25-12-22(13-33-28(24)25)35-20-3-2-4-21(35)16-37-15-20/h5-8,12-14,17-21H,2-4,9-11,15-16,31H2,1H3,(H,34,36)/t17-,18+,19-,20?,21?/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376776
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC2(CCC2)C1
Show InChI InChI=1/C28H32FN5O/c1-17-9-18(11-19(30)10-17)21-5-8-31-14-25(21)33-27(35)22-3-4-24(29)23-12-20(13-32-26(22)23)34-15-28(16-34)6-2-7-28/h3-5,8,12-14,17-19H,2,6-7,9-11,15-16,30H2,1H3,(H,33,35)/t17-,18+,19-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376696
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H](O)[C@@H](F)C1
Show InChI InChI=1/C27H31F2N5O2/c1-15-8-16(10-17(30)9-15)19-4-6-31-13-24(19)33-27(36)20-2-3-22(28)21-11-18(12-32-26(20)21)34-7-5-25(35)23(29)14-34/h2-4,6,11-13,15-17,23,25,35H,5,7-10,14,30H2,1H3,(H,33,36)/t15-,16+,17-,23-,25-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376779
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC2COCC2C1
Show InChI InChI=1/C28H32FN5O2/c1-16-6-17(8-20(30)7-16)22-4-5-31-11-26(22)33-28(35)23-2-3-25(29)24-9-21(10-32-27(23)24)34-12-18-14-36-15-19(18)13-34/h2-5,9-11,16-20H,6-8,12-15,30H2,1H3,(H,33,35)/t16-,17+,18?,19?,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376787
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COC1(C)CN(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C27H32FN5O2/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,15-33)35-3/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376789
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCOc2cccc(F)c12
Show InChI InChI=1/C30H29F2N5O2/c1-17-11-18(13-19(33)12-17)21-7-8-34-16-26(21)36-30(38)22-5-6-24(31)23-14-20(15-35-28(22)23)37-9-10-39-27-4-2-3-25(32)29(27)37/h2-8,14-19H,9-13,33H2,1H3,(H,36,38)/t17-,18+,19-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376791
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CCOC1CN(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C27H32FN5O2/c1-3-35-20-14-33(15-20)19-11-23-24(28)5-4-22(26(23)31-12-19)27(34)32-25-13-30-7-6-21(25)17-8-16(2)9-18(29)10-17/h4-7,11-13,16-18,20H,3,8-10,14-15,29H2,1-2H3,(H,32,34)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376793
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCN(C)CC1
Show InChI InChI=1/C28H35FN6O/c1-18-12-19(14-20(30)13-18)22-6-7-31-17-26(22)33-28(36)23-4-5-25(29)24-15-21(16-32-27(23)24)35-9-3-8-34(2)10-11-35/h4-7,15-20H,3,8-14,30H2,1-2H3,(H,33,36)/t18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376797
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCN(C)S1(=O)=O
Show InChI InChI=1/C26H31FN6O3S/c1-16-10-17(12-18(28)11-16)20-6-7-29-15-24(20)31-26(34)21-4-5-23(27)22-13-19(14-30-25(21)22)33-9-3-8-32(2)37(33,35)36/h4-7,13-18H,3,8-12,28H2,1-2H3,(H,31,34)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376798
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(Nc3ccccc3C#N)cnc12
Show InChI InChI=1/C29H27FN6O/c1-17-10-19(12-20(32)11-17)22-8-9-33-16-27(22)36-29(37)23-6-7-25(30)24-13-21(15-34-28(23)24)35-26-5-3-2-4-18(26)14-31/h2-9,13,15-17,19-20,35H,10-12,32H2,1H3,(H,36,37)/t17-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376799
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCc2ccccc12
Show InChI InChI=1/C31H32FN5O/c1-19-13-21(15-22(33)14-19)24-10-11-34-18-28(24)36-31(38)25-8-9-27(32)26-16-23(17-35-30(25)26)37-12-4-6-20-5-2-3-7-29(20)37/h2-3,5,7-11,16-19,21-22H,4,6,12-15,33H2,1H3,(H,36,38)/t19-,21+,22-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376808
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1ncccc1OC(F)F
Show InChI InChI=1/C29H29F3N6O2/c1-16-10-17(12-18(33)11-16)20-7-9-34-15-24(20)37-28(39)21-5-6-23(30)22-13-19(14-36-26(21)22)38(2)27-25(40-29(31)32)4-3-8-35-27/h3-9,13-18,29H,10-12,33H2,1-2H3,(H,37,39)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376814
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1ccncc1F
Show InChI InChI=1/C28H28F2N6O/c1-16-9-17(11-18(31)10-16)20-5-7-33-15-25(20)35-28(37)21-3-4-23(29)22-12-19(13-34-27(21)22)36(2)26-6-8-32-14-24(26)30/h3-8,12-18H,9-11,31H2,1-2H3,(H,35,37)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376821
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376826
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1C[C@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17-,18+,19-,21-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376828
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376835
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@H]1CCN1c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C26H30FN5O/c1-15-9-17(11-18(28)10-15)20-5-7-29-14-24(20)31-26(33)21-3-4-23(27)22-12-19(13-30-25(21)22)32-8-6-16(32)2/h3-5,7,12-18H,6,8-11,28H2,1-2H3,(H,31,33)/t15-,16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376668
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCC[C@@H](F)C1
Show InChI InChI=1/C27H31F2N5O/c1-16-9-17(11-19(30)10-16)21-6-7-31-14-25(21)33-27(35)22-4-5-24(29)23-12-20(13-32-26(22)23)34-8-2-3-18(28)15-34/h4-7,12-14,16-19H,2-3,8-11,15,30H2,1H3,(H,33,35)/t16-,17+,18+,19-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376671
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H](F)C1
Show InChI InChI=1/C26H29F2N5O/c1-15-8-16(10-18(29)9-15)20-4-6-30-13-24(20)32-26(34)21-2-3-23(28)22-11-19(12-31-25(21)22)33-7-5-17(27)14-33/h2-4,6,11-13,15-18H,5,7-10,14,29H2,1H3,(H,32,34)/t15-,16+,17-,18-/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376673
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@@H](C1)C#N
Show InChI InChI=1/C27H29FN6O/c1-16-8-18(10-19(30)9-16)21-4-6-31-14-25(21)33-27(35)22-2-3-24(28)23-11-20(13-32-26(22)23)34-7-5-17(12-29)15-34/h2-4,6,11,13-14,16-19H,5,7-10,15,30H2,1H3,(H,33,35)/t16-,17+,18+,19-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376676
PNG
(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCOCC1
Show InChI InChI=1/C26H30FN5O2/c1-16-10-17(12-18(28)11-16)20-4-5-29-15-24(20)31-26(33)21-2-3-23(27)22-13-19(14-30-25(21)22)32-6-8-34-9-7-32/h2-5,13-18H,6-12,28H2,1H3,(H,31,33)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%